CN110496274A - A prefilled syringe for dissolving medicine and a dispensing device - Google Patents

Abstract

The invention discloses a prefilled syringe for dissolving medicine, which comprises a push rod, a piston, a syringe and a protective cap. Fittingly connected, the protective cap is sealed and connected to the opening of the dissolving joint. When dispensing the medicine, first remove the protective cap of the prefilled syringe for dissolving the drug and the protective cap of the prefilled syringe for injection, and then directly fit the drug dissolving joint with the outer conical joint of the prefilled syringe for injection, Then reciprocally push the push rods of the two syringes for dispensing. After the drug is fully dissolved, directly remove the prefilled syringe for dissolving the drug. Finally, install a needle on the outer conical joint of the prefilled syringe for injection to start injection. This solution simplifies the dispensing process, reduces the workload of medical staff, and avoids puncture debris and cross-contamination. The invention also discloses a dispensing device comprising the pre-filled syringe for injection and the above-mentioned pre-filled syringe for dissolving medicine.

Description

A prefilled syringe for dissolving medicine and a dispensing device

technical field

The invention relates to the technical field of medicine packaging, in particular to a prefilled syringe for dissolving medicine and a dispenser.

Background technique

Pre-filled syringes have both functions of storing drugs and ordinary injections, which bring many advantages to pharmaceutical companies and clinical use. With the development of prefilled syringe technology, prefilled syringes have become the main packaging method for high-end pharmaceuticals such as biological agents and chemical drugs due to their convenient use and excellent safety.

For medicines that need to be dissolved or prepared before clinical injection, dispensing is a very important process. The existing dispensing process is generally that powder or freeze-dried powder medicines are packed in vials, and the solvent for dissolving the medicines is packed in pre-filled syringes. When dissolving, install the dispensing device or dissolving needle on the prefilled syringe, pierce the stopper of the vial with the needle tip, inject the solvent into the vial, pull out the syringe with the dispensing device or dissolving needle, and shake the vial bottle, dissolve the drug, and then insert the syringe into the stopper of the vial to suck out the drug. Rotate and unscrew the dispensing device or dissolving needle, replace the injection needle, and then perform normal operation.

In the existing technology of dispensing medicine with prefilled syringes, there is a very large risk during use. Repeated punctures will cause the cork to fall off, resulting in particles in the liquid medicine; in addition, repeated punctures and replacement of the dispenser will increase the crossover risk of contamination.

Therefore, how to make the dispensing process of prefilled syringes safer and more convenient is a technical problem that those skilled in the art need to solve at present.

Contents of the invention

In view of this, the object of the present invention is to provide a prefilled syringe for dissolving medicine, which is used to simplify the dispensing process of the prefilled syringe, reduce the workload of medical staff, and reduce the risk of cross-infection during the dispensing process. Another object of the present invention is to provide a dispenser comprising the above-mentioned prefilled syringe for dissolving medicine.

In order to achieve the above object, the present invention provides the following technical solutions:

A prefilled syringe for dissolving medicine, including a push rod, a piston, a syringe and a protective cap, the syringe is provided with a dissolving joint, and the dissolving joint is used to connect with the outer conical joint of the prefilled syringe for injection Fittingly connected, the protective cap is sealed and connected to the opening of the drug-dissolving joint.

Preferably, the drug-dissolving joint is an inner conical joint for mating connection with the outer wall of the outer conical joint of the prefilled syringe for injection.

Preferably, the inner conical joint is a 6% inner conical joint.

In another preferred solution, the drug-dissolving joint is a drug-dissolving outer conical joint used to cooperate with the inner wall of the outer conical joint of the prefilled syringe for injection.

Preferably, the drug-dissolving outer conical joint is a 6% outer conical joint.

Preferably, the outer wall of the drug-dissolving joint is provided with a threaded connection part.

Preferably, the protective cap includes a cylindrical shell and a sealed inner core located inside the shell, the sealed inner core is in sealing fit with the inner hole of the drug-dissolving joint, and the inner wall of the outer shell is in contact with the drug-dissolving joint. Said threaded connection portion of the outer wall of the joint is threaded.

Preferably, anti-slip ribs are provided on the outer periphery of the housing.

Preferably, the drug-dissolving joint and the syringe are integrally structured.

Preferably, both the drug-dissolving joint and the syringe are made of plastic.

In another preferred solution, the syringe is a glass syringe, the drug-dissolving joint is made of plastic, and the opening of the glass syringe is fixedly connected to the drug-dissolving joint through a snap ring.

The process of using this program is as follows:

The syringe of the prefilled syringe for dissolving medicine is preloaded with medicine or solvent, and the prefilled syringe for injection is preloaded with medicine. When dispensing, first remove the protective cap of the prefilled syringe for dissolving medicine and the protective cap of the prefilled syringe for injection, and then connect the dissolving joint of the prefilled syringe for dissolving medicine with the prefilled syringe for injection. The outer conical joints of the two syringes are directly matched and connected. At this time, the syringes of the two syringes are connected, and then the push rods of the two syringes are reciprocally pushed to dispense the medicine. After the medicine is fully dissolved, the prefilled syringe for dissolving the medicine is directly removed. At this time, the mixed and dissolved medicine remains in the syringe of the prefilled syringe for injection, and finally, the injection can be performed by installing a needle on the outer conical joint of the prefilled syringe for injection.

This program has the following beneficial effects:

1) Compared with the existing dispensing process, this solution saves two dissolving needles and consumables;

2) This solution can greatly reduce the dispensing steps, and reduce the workload and labor intensity of medical staff;

3) Since the dispensing process is further simplified, the risk of cross-contamination during the dispensing process is greatly reduced;

4) This solution can avoid the process of puncturing the bottle stopper during the whole dispensing process, avoiding the particle pollution caused by puncture debris from the source, thus making the injection safer.

The solution also provides a drug dispenser, including a prefilled syringe for injection and the above-mentioned prefilled syringe for dissolving medicine. The derivation process of the beneficial effect produced by the dispenser is generally similar to the derivation process of the beneficial effect brought by the above-mentioned prefilled syringe for dissolving medicine, so it will not be repeated here.

Preferably, the outer ring of the outer conical joint of the prefilled syringe for injection is also provided with a connecting sleeve, and a connection gap is reserved between the inner wall of the connecting sleeve and the outer wall of the outer conical joint, and the solution The drug joint is an inner conical joint used to cooperate with the outer wall of the outer conical joint. The outer wall of the inner conical joint is provided with a threaded connection portion, and the inner wall of the connecting sleeve is provided with a threaded joint that can be connected with the inner conical joint. A locking threaded connection that engages the threads of the outer wall.

Preferably, the above-mentioned dispenser further includes a needle used to cooperate with the outer conical joint of the prefilled syringe for injection.

Description of drawings

In order to more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the following will briefly introduce the drawings that need to be used in the description of the embodiments or the prior art. Obviously, the accompanying drawings in the following description are only These are some embodiments of the present invention. Those skilled in the art can also obtain other drawings based on these drawings without creative work.

Fig. 1 is the overall sectional view of the prefilled syringe for dissolving medicine in the specific embodiment of the present invention;

Fig. 2 is the structural representation of the protective cap of the prefilled syringe for dissolving medicine in the specific embodiment of the present invention;

3 is an overall sectional view of a prefilled syringe for injection in a specific embodiment of the present invention;

4 is a cross-sectional view of the first protective cap of the prefilled syringe for injection in a specific embodiment of the present invention;

5 is a cross-sectional view of a second protective cap of a prefilled syringe for injection in a specific embodiment of the present invention;

Fig. 6 is a schematic diagram of the structure when the prefilled syringe for dissolving medicine and the prefilled syringe for injection are interconnected for dispensing in a specific embodiment of the present invention;

7 is a schematic diagram of the interconnection structure of the drug-dissolving joint and the outer conical joint of the prefilled syringe for injection in a specific embodiment of the present invention;

Figure 8 is a cross-sectional view of another prefilled syringe for dissolving medicine in a specific embodiment of the present invention;

Fig. 9 is a schematic diagram of the connection structure between the protective cap, the drug-dissolving joint and the syringe in Fig. 8 .

In Figure 1 to Figure 9:

1-the first push rod, 2-the first piston, 3-the first syringe, 4-the first drug, 5-the drug-dissolving joint, 6-the first protective cap, 61-the first shell, 62-the first fit Thread, 63-first sealing inner core, 64-anti-slip rib, 7-second protective cap, 8-outer conical joint, 9-second medicine, 10-second piston, 11-second push rod, 12-first Two syringes, 71-second shell, 72-second sealed inner core, 73-second matching thread, 13-connecting sleeve, 51-threaded connection part, 31-clip ring.

Detailed ways

The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

In order to simplify the dispensing process of prefilled syringes, reduce the workload of medical staff, and reduce the risk of cross-contamination during the dispensing process. The present invention provides a prefilled syringe for dissolving medicine. As shown in FIG. The barrel 3 is provided with a drug-dissolving joint 5, which is used to cooperate with the outer conical joint 8 of the prefilled syringe for injection (as shown in Figures 6 and 7), and the first protective cap 6 is hermetically connected to the drug-dissolving joint. Opening for connector 5.

The process of using this program is as follows:

The first syringe 3 of the prefilled syringe for dissolving medicine is preloaded with a first medicine 4 or a solvent, and the prefilled syringe for injection is preloaded with a second medicine 9 . When dispensing, first remove the first protective cap 6 of the prefilled syringe for dissolving medicine and the second protective cap 7 of the prefilled syringe for injection, and then remove the dissolving joint 5 of the prefilled syringe for dissolving medicine. It is directly matched and connected with the outer conical joint 8 of the prefilled syringe for injection, as shown in Figure 6. At this time, the syringes of the two syringes can be connected, and then the push rods of the two syringes are reciprocally pushed for dispensing. After dissolving, directly take off the prefilled syringe for dissolving the medicine, at this time, the mixed and dissolved medicine (i.e. the mixed liquid medicine of the first medicine 4 and the second medicine 9) stays in the syringe of the prefilled syringe for injection, Finally, the injection can be performed by installing a needle on the outer conical joint 8 of the prefilled syringe for injection.

It should be noted that the drug-dissolving joint 5 of the pre-filled syringe for dissolving medicine in the present invention can be designed in various structural forms, for example, an inner conical joint designed to cooperate with the outer wall of the outer conical joint; An external conical joint that matches the inner wall of the conical joint; or a straight joint that is designed to match the inner wall of the external conical joint and whose outer wall surface is a cylindrical surface; etc. In a preferred solution, the dissolving joint 5 is designed as an inner conical joint for mating connection with the outer wall of the outer conical joint 8 of the prefilled syringe for injection, as shown in FIGS. 1 and 6 . Further preferably, the inner conical joint of the drug-dissolving prefilled syringe is a 6% inner conical joint. The 6% inner conical joint can be a locking joint or a straight joint. The interconnection through the connection method of the 6% conical joint can ensure the tightness of the interconnection. Of course, the locking joint will have better connection firmness.

In another preferred solution, the drug-dissolving joint 5 is a drug-dissolving outer conical joint for matching with the inner wall of the outer conical joint 8 of the prefilled syringe for injection, that is, the outer wall surface of the drug-dissolving joint 5 is a conical surface, When connecting two syringes, the dissolving joint 5 is inserted into the outer conical joint 8 of the prefilled syringe for injection. Further preferably, the drug-dissolving outer conical joint is a 6% outer conical joint, which also ensures the tightness of the interconnection.

Please refer to FIG. 7 , preferably, the outer wall of the drug-dissolving joint 5 is provided with a threaded connection portion 51 , that is, the drug-dissolving joint 5 is designed as a locking joint with a threaded locking function. In this way, the prefilled syringe for dissolving medicine can be locked and interconnected with the prefilled syringe for injection provided with the outer conical locking joint, so as to ensure the firmness of the connection of the two syringes, thereby ensuring the operational safety during the dispensing process.

Please refer to FIG. 2 , preferably, the first protective cap 6 includes a cylindrical first outer shell 61 and a first sealed inner core 63 located inside the first outer shell 61 , the first sealed inner core 63 is connected to the inner hole of the drug-dissolving joint 5 Sealing fit, the inner wall of the first shell 61 is threadedly fitted with the threaded connection portion 51 of the outer wall of the drug-dissolving joint 5, as shown in Figure 2, the inner wall of the first shell 61 is provided with a first fit for threaded engagement with the threaded connection portion 51 Thread 62. In this way, after the first protective cap 6 is installed on the drug-dissolving joint 5, the first sealing inner core 63 is closely matched with the inner hole of the drug-dissolving joint 5 to play a sealing role and prevent the internal liquid medicine from being polluted; the first shell 61 The internal first mating thread 62 forms a threaded fit with the threaded connection portion 51 of the drug-dissolving joint 5. Compared with the smooth surface fit of conventional rubber parts, this structure has a better connection effect, and is especially suitable for filling the drug solution. Products that require high temperature sterilization can effectively prevent cap bursting caused by the imbalance of internal and external pressure during the sterilization process.

The first protective cap 6 of the prefilled syringe for dissolving medicine can be made of plastic or rubber. Commonly used plastic materials are PP, PE, COP, COC, PC, etc. Commonly used rubber materials include: bromobutyl rubber, polyester Isoprene, mixed rubber, nitrile, styrene-butadiene or TPE elastomer, etc.

Further preferably, an anti-slip rib 64 is provided on the outer periphery of the first housing 61 , so that it is convenient for the medical personnel to manually rotate the first protective cap 6 , so as to conveniently remove the first protective cap 6 .

It should be noted that the drug dissolving joint 5 and the first syringe 3 of the prefilled syringe for dissolving medicine provided in the present invention can be designed as an integrated structure, or can be designed as a split structure. In a preferred solution, the drug-dissolving joint 5 and the first syringe 3 are of an integral structure.

The drug-dissolving joint 5 and the first syringe 3 above can be made of plastic or glass. In a preferred solution, the drug-dissolving joint 5 and the first syringe 3 are both made of plastic, that is, the drug-dissolving joint 5 and the first syringe 3 are made of plastic. The first syringe 3 is an integral plastic part. Plastic syringes are generally made of PP, PE, COP, COC, PC and other plastic materials commonly used in pharmaceutical packaging materials. These materials have excellent safety and drug compatibility.

In another preferred solution, the drug-dissolving joint 5 and the first syringe 3 have a split structure, the first syringe 3 is a glass syringe, the drug-dissolving joint 5 is made of plastic, and the opening of the glass syringe passes through the snap ring 31 It is fixedly connected with the drug-dissolving joint 5, as shown in Figure 8 and Figure 9, the clasp 31 specifically includes an outer peripheral flange arranged at the port of the glass syringe, and the inner ring of the drug-dissolving joint 5 is provided with a snap fit with the clasp 31. The ring-shaped locking groove, the snap ring 31 can restrict the movement of the drug-dissolving joint 5 relative to the glass syringe in the axial direction, so as to ensure that the drug-dissolving joint 5 will not break away from the glass syringe. Glass syringes are generally made of neutral borosilicate glass, of course, other glass syringes such as soda-lime glass or colored glass can also be used in this program.

In addition, the first piston 2 of the prefilled syringe for dissolving medicine is generally made of chlorinated butyl rubber, brominated butyl rubber, thermoplastic elastomer and other materials.

This program has the following beneficial effects:

1) Compared with the existing dispensing process, this solution saves two dissolving needles and consumables;

2) This solution can greatly reduce the dispensing steps, and reduce the workload and labor intensity of medical staff;

3) Since the dispensing process is further simplified, the risk of cross-contamination during the dispensing process is greatly reduced;

4) This solution can avoid the process of puncturing the bottle stopper during the whole dispensing process, avoiding the particle pollution caused by puncture debris from the source, thus making the injection safer.

The solution also provides a drug dispenser, including a prefilled syringe for injection and the above-mentioned prefilled syringe for dissolving medicine. The derivation process of the beneficial effect produced by the dispenser is generally similar to the derivation process of the beneficial effect brought by the above-mentioned prefilled syringe for dissolving medicine, so it will not be repeated here.

As shown in Figure 3 and Figure 6, the first syringe 3 of the prefilled syringe for dissolving medicine provided by the present invention is filled with the first drug 4 in advance, and the prefilled syringe for injection specifically includes a second needle Barrel 12, second push rod 11, second piston 10, outer conical joint 8 and second protective cap 7, the second drug 9 is filled in advance in the second syringe 12, when dispensing, directly connect two syringes Even, the first drug 4 and the second drug 9 in the two syringes can communicate and dissolve.

As shown in Figure 7, preferably, the outer ring of the outer conical joint 8 of the prefilled syringe for injection is also provided with a connecting sleeve 13, and a connection gap is reserved between the inner wall of the connecting sleeve 13 and the outer wall of the outer conical joint 8 , during dispensing, the drug-dissolving joint 5 is accommodated in the connection gap, the drug-dissolving joint 5 is an inner conical joint used to cooperate with the outer wall of the outer conical joint 8, and the outer wall of the inner conical joint is provided with a threaded connection portion 51, which is connected The inner wall of the sleeve 13 is provided with a locking screw connection part capable of screwing with the outer wall of the inner conical joint. In this way, the outer conical joint 8 of the prefilled syringe for injection and the dissolving joint 5 of the prefilled syringe for dissolving medicine are both designed as locking joints, which can ensure better connection and firmness of the two syringes during the dispensing process. Spend.

It should be noted that the above-mentioned external conical joints and internal conical joints are preferably designed as 6% conical joints to meet the standardization requirements. Of course, the external conical joints and internal conical joints described in the present invention can also be designed as non-standard conical joints , can also achieve a sealed connection.

It should be noted that the structure of the second protective cap 7 of the prefilled syringe for injection in this solution includes a second shell 71 and a second sealing inner core 72, and the second protective cap 7 generally has a plastic protective cap, a rubber protective cap Or several forms such as rubber inner core and plastic shell combined protective cap. Typical rubber cap structure is, please refer to Fig. 4 and Fig. 5, the second housing 71 profile of the second cap 7 can be straight (as shown in Fig. 5), also can have external thread (as shown in Fig. 4 The structure of the second matching thread 73 provided on the outer periphery of the second shell 71 shown). Commonly used materials for rubber protective caps include: bromobutyl rubber, polyisoprene, rubber compound, nitrile, styrene-butadiene or TPE elastomers.

Plastic protective cap or protective cap with a plastic shell, the material of the rubber part is also: bromobutyl rubber, polyisoprene, mixed rubber, nitrile, styrene-butadiene or TPE elastomer, etc., commonly used materials for the plastic part For: PP, PE, COP, COC, PC, etc.

Preferably, the dispenser provided by the present invention also includes a needle for cooperating with the outer conical joint 8 of the prefilled syringe for injection. In this way, the dispenser includes a needle matched with the prefilled syringe for injection, so that it can It is further convenient for medical personnel to perform dispensing and injection operations, and work efficiency is improved.

The above description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the invention. Therefore, the present invention will not be limited to the embodiments shown herein, but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims (14)

1. a kind of molten medicinal pre-encapsulated injector, including push rod, piston, syringe and helmet, which is characterized in that the syringe is equipped with Molten medicine connector (5), the molten medicine connector (5) are used to be cooperatively connected with the outer circle taper joint (8) of injection pre-encapsulated injector, institute State the opening that helmet is sealedly attached to the molten medicine connector (5).

2. molten medicinal pre-encapsulated injector according to claim 1, which is characterized in that the molten medicine connector (5) be for The inner circle taper joint being cooperatively connected with the outer wall of the outer circle taper joint (8) of injection pre-encapsulated injector.

3. molten medicinal pre-encapsulated injector according to claim 2, which is characterized in that the inner circle taper joint is in 6% Cone joint.

4. molten medicinal pre-encapsulated injector according to claim 1, which is characterized in that the molten medicine connector (5) be for The molten medicine outer circle taper joint cooperated with the inner wall of the outer circle taper joint (8) of injection pre-encapsulated injector.

5. molten medicinal pre-encapsulated injector according to claim 4, which is characterized in that the molten medicine outer circle taper joint is 6% outer circle taper joint.

6. molten medicinal pre-encapsulated injector according to claim 2 or 3, which is characterized in that outside the molten medicine connector (5) Wall is equipped with threaded joints (51).

7. molten medicinal pre-encapsulated injector according to claim 6, which is characterized in that the helmet includes the shell of tubular With the sealing inner core in the portion that is located in the shell, the inner hole of the sealing inner core and the molten medicine connector (5), which seals, to be cooperated, described The inner wall of shell and the threaded joints (51) of the outer wall of the molten medicine connector (5) are threadedly engaged.

8. molten medicinal pre-encapsulated injector according to claim 7, which is characterized in that the periphery of the shell is equipped with anti-skidding Muscle (64).

9. molten medicinal pre-encapsulated injector according to claim 1, which is characterized in that the molten medicine connector (5) with it is described Syringe is an integral structure.

10. molten medicinal pre-encapsulated injector according to claim 9, which is characterized in that the molten medicine connector (5) with it is described Syringe is plastic material.

11. molten medicinal pre-encapsulated injector according to claim 1, which is characterized in that the syringe is glass syringe, institute Stating molten medicine connector (5) is plastic material, and the opening of the glass syringe passes through snap ring (31) and the fixed company of the molten medicine connector (5) It connects.

12. a kind of dispenser, which is characterized in that including injection pre-encapsulated injector and such as any one of claims 1 to 11 The molten medicinal pre-encapsulated injector.

13. dispenser according to claim 12, which is characterized in that the outer circle tapered joint of the injection pre-encapsulated injector The outer ring of head (8) is additionally provided with connection sleeve (13), and the inner wall for connecting sleeve (13) is outer with the outer circle taper joint (8) Joint gap is reserved between wall, the molten medicine connector (5) is for interior with the mating connection of the outer wall of the outer circle taper joint (8) The outer wall of cone joint, the inner circle taper joint is equipped with threaded joints (51), and the inner wall of connection sleeve (13) is equipped with energy The locking screw thread interconnecting piece that enough outer wall threads with the inner circle taper joint cooperate.

14. dispenser according to claim 12, which is characterized in that further include for being injected with the pre- encapsulating of the injection The syringe needle of outer circle taper joint (8) cooperation of device.