CN110451529A - A kind of method of purification of sodium chloride for injection - Google Patents
A kind of method of purification of sodium chloride for injection Download PDFInfo
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- CN110451529A CN110451529A CN201910647691.7A CN201910647691A CN110451529A CN 110451529 A CN110451529 A CN 110451529A CN 201910647691 A CN201910647691 A CN 201910647691A CN 110451529 A CN110451529 A CN 110451529A
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- sodium chloride
- nanofiltration system
- nanofiltration
- injection
- solution
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- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01D—COMPOUNDS OF ALKALI METALS, i.e. LITHIUM, SODIUM, POTASSIUM, RUBIDIUM, CAESIUM, OR FRANCIUM
- C01D3/00—Halides of sodium, potassium or alkali metals in general
- C01D3/14—Purification
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- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2006/00—Physical properties of inorganic compounds
- C01P2006/80—Compositional purity
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- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Inorganic Chemistry (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Abstract
The invention discloses a kind of methods of purification of sodium chloride for injection, are related to medical supplies preparation technical field.Crude salt is dissolved in pure water first, then it is filtered using ultrafiltration or micro-filtration, remove larger molecular organics, colloid and the particle in solution, it is handled again using second level nanofiltration system filtrate, two-stage nanofiltration system is used in conjunction, the sulfate radical in solution can be effectively removed, nanofiltration system penetrating fluid is pumped into evaporator, is heated in the process using steam, Steam pressure control is in 0.1-0.15Mpa, in the process, nanofiltration system penetrating fluid is become being saturated from unsaturation, and sodium chloride crystallization is precipitated, sodium chloride further purifies while precipitation, it finally filters, dry, packaging.Entire technique combines ultrafiltration/micro-filtration and nanofiltration system, is handled completely using membrane process craft, and simple process, stable effluent quality are easy to control and realize automation, and the sodium chloride as impurity content that final refining obtains is low, and the index of injection is fully achieved.
Description
Technical field
The present invention relates to medical supplies preparation technical fields, and in particular to a kind of method of purification of sodium chloride for injection.
Background technique
Sodium chloride injection primary treatment: dehydration caused by a variety of causes, including hypo-osmoticity, isotonicity and hypertonicity are lost
Water；Hyperosmolar nonketotic diabetic coma can correct dehydration and isotonic state using isotonic or hypotonic sodium chloride；Low chlorine metabolism
Property alkalosis.Sodium chloride injection is a kind of traditional medicine that our times various countries clinically generally use in the medical field
Product, patient is in use, directly enter blood circulation system by intramuscular injection, due to miscellaneous containing many nocuousness in crude salt sodium chloride
Matter will cause many complication into blood, cause to damage to the body of patient if do not removed, although currently having very much
Chemical plant, which has, purifies crude salt.As shown in Figure 1, crude salt is dissolved first, is then added for traditional crude salt purifying technique
Barium chloride sedimentation removal sulfate ion, the barium ions that then addition sodium carbonate sedimentation removal introduces, then by supernatant by surpassing
Filter or microfiltration membrane system filtering, finally by the salt slurry being recrystallized to give twice filtering, dry, packaging.The shortcomings that this technique: 1. add
Enter barium chloride and sodium carbonate needs charging tank, area occupied is larger, complicated for operation；2. need to be added twice reagent barium chloride and
Sodium carbonate, barium chloride itself has toxicity, and will increase reagent cost；3. it is made a return journey sulfate radical using the precipitation method, such sulphur
The removal rate of acid group is not high, cannot thoroughly remove sulfate radical；4. vapo(u)rizing temperature needs 130 degree using distilling twice, it may be desirable to
Very high energy consumption, to increase cost；5. during crystallization, some solubility such as sodium sulphate and part metals cation
Similar substance can not be removed there are in crystalline solid.
Summary of the invention
Present invention aims to overcome that disadvantage of the existing technology, seeks the preparation side for designing a kind of medical grade sodium chloride
Method and device.
To achieve the above object, the invention adopts the following technical scheme:
A kind of method of purification of sodium chloride for injection, comprising the following steps:
(1) crude salt is dissolved in pure water, obtains the sodium chloride solution of 300g/L, in the solution except containing calcium, magnesium, iron and
Outside some heavy metal ion elements, also contain the sodium sulphate of about 2g/L；
(2) sodium chloride solution is filtered using ultrafiltration or micro-filtration, removes larger molecular organics in solution, colloid and micro-
Grain；
(3) step (2) water outlet is separated using second level nanofiltration system, two-stage nanofiltration system is used in conjunction, and can effectively go
Except the sulfate radical in solution；
(3) nanofiltration system penetrating fluid is pumped into evaporator, is heated in the process using steam, Steam pressure control is in 0.1-
0.15Mpa, in the process, nanofiltration system penetrating fluid are become being saturated from unsaturation, and sodium chloride crystallization is precipitated, while sodium chloride is precipitated
Further purification；
(4) step (3) salt slurry is squeezed into lautertuns, is filtered using traditional micro-filtration or ultra-filtration and separation technique, by chlorine
Change sodium crystal retention；
(5) salt that filter comes out, which enters in drying bed, is dried, and sufficiently after drying, packs according to medical rank, should
Product is the standard that can reach the other injection sodium chloride of pharmaceutical grade, subsequent to prepare the salt of various concentration according to actual needs
Water is used for hospital patient.
Further, the rate of recovery of first order nanofiltration can reach 90%, and the penetrating fluid of the nanofiltration of the first order is as the second level
The water inlet of nanofiltration, the rate of recovery of second level nanofiltration can reach 95%, and overall recovery reaches 85.5%.
Further, in step (2) and (4), filter membrane used is polysulfones, polyether sulfone or polyvinylidene fluoride, feeds hydraulic pressure
Power < 10bar, the particulate that membrane aperture is 0.001-0.1 μm, molecular cut off 1000-30000Da.
Compared with the prior art, the invention has the following beneficial effects: (1) entire technique is by ultrafiltration/micro-filtration and nanofiltration system
In conjunction with completely using membrane process craft processing, simple process, stable effluent quality are easy to control and realize automation；(2) it reduces
The use of chemical agent avoids generating a large amount of solid waste；(3) the sodium chloride as impurity content that final refining obtains is low, complete
Reach the index of injection entirely.
Detailed description of the invention
Fig. 1 is the purifying technique flow chart of sodium chloride for injection in traditional handicraft.
Fig. 2 is the purifying technique flow chart of sodium chloride for injection in the embodiment of the present invention 1.
Specific embodiment:
Invention is described further below by specific embodiment and in conjunction with attached drawing.
Embodiment 1
As shown in Figure 1, a kind of sodium chloride for injection purifying technique, specifically includes the following steps:
(1) crude salt is added in pure water, heating stirring dissolves it sufficiently, is dissolved into the sodium chloride solution of 300g/L, should
In solution in addition to containing calcium, magnesium, iron and some heavy metal elements, also contain the sodium sulphate of about 2g/L, this solution is subjected to pre- mistake
Filter, the pre-filtering use micro-filtration or ultrafiltration system, and filter membrane used is polysulfones, polyether sulfone or polyvinylidene fluoride, feed hydraulic pressure
Power < 10bar is higher than 99% to the rate of recovery of its solution, can filter out the particulate that partial size is 0.01-0.1 μm, retention point
Son amount is 1000-30000Da, and for removing the suspended matter in solution, solution turbidity < 0.5NT after filtering it can be with
Greatly reduce nanofiltration membrane fouling in subsequent technique；
(2) be then filtered by a multistage nanofiltration system, multistage nanofiltration system include first order nanofiltration system and
Hydraulic pressure is fed in second level nanofiltration system, the standard cell block that first order nanofiltration system is connected by several series systems, water inlet
Power is 25-30bar, and temperature enters standard block room, water and sodium chloride by nanofiltration membrane, generates one in contrast when being room temperature
The water inlet lower osmotic flow of impurity, the metal cation and sulfate radical of multivalence are retained by nanofiltration membrane, or because electrostatic repulsion machine
Retention of being ostracised is made, nanofiltration membrane surface layer has charge or positive or negative, this depends on solution and mixes the pH value condition made, when this
Solution containing metal ion flows through nanofiltration film surface, since solution is per se with certain net charge, film is allowed to go to retain
Effects of ion type metal impurities.Nanofiltration membrane, which refers to the retention of metal ion, does not allow these metal ions to pass through, and forms one
The retention water flow of the stock higher metal impurities of content, referred to as concentrate.The rate of recovery of the first order nanofiltration system is
90%, 98% can reach to the rejection of sulfate radical, the rejection of other metallic elements reaches 90% or more, i.e., vertical for every 1
The water inlet of square rice can produce 0.1 cubic metre of retention water flow.Second level nanofiltration system is similar with first order nanofiltration system, by several
The standard block room of connection forms, but the nanofiltration system unit of the second level is less than first order nanofiltration system unit, and described the
Second level nanofiltration system is further processed the osmotic flow that first order nanofiltration system is sent, to further decrease the number of impurity in solution
Amount, to improve the purity of salt, the multistage nanofiltration system is by the nanofiltration of commercial criterion size (such as 4 inches or 8 inches)
Module composition, nanofiltration membrane are retention and the stable nanofiltration membrane of flux, selectivity and > 1L/m with > 98%2-hr-bar
Circulation performance.Multistage nanofiltration system is 80% to 85% to the rate of recovery of water, here sulfuric acid in 80% to 85% penetrating fluid
The concentration < 2ppm of root, the only micro metal impurities for being suitable for recycling or reusing generate in concentrate, and solution
It is pollution-free for neutrality, it can be directly discharged in the Nature；Or be recycled directly in technological operation and reuse, do not do anyization
Processing, such as: it returns in the first order nanofiltration system water inlet circuit after filtering, by the concentration after the retention of multistage nanofiltration system
Sodium chloride and a large amount of metal impurities and sulfate radical in liquid containing high concentration can enter the first order and separate again.
(3) the penetrating fluid evaporative crystallization for obtaining multistage nanofiltration system, nanofiltration system penetrating fluid contain the chlorine of very high concentration
Change sodium, the sodium chloride of > 300g/L, the sulfate radical of < 2ppm, the content of other metal cations is also very micro, at 100 DEG C of >
Turret in be evaporated crystallization, further increase the purity of its sodium chloride；
(4) crystalline solid after crystallization is filtered, the filtering uses micro-filtration or ultrafiltration system, and filter membrane used is poly-
Sulfone, polyether sulfone or polyvinylidene fluoride feed water pressure < 10bar, are higher than 99% to the rate of recovery of its solution, can obtain more
Pure sodium chloride particle.Then will after filtering obtained granulated salt be sent in 100 DEG C of drying tower be dried to get
To more pure sodium chloride product, the sodium chloride after purifying meets sodium chloride in Chinese Pharmacopoeia (injection) standard and (is shown in Table
1)。
Table 1
Obviously, examples detailed above of the invention is just for the sake of clearly illustrating examples of the invention, and being not is pair
The restriction of embodiments of the present invention.For those of ordinary skill in the art, may be used also on the basis of the above description
To make other variations or changes in different ways, there is no necessity and possibility to exhaust all the enbodiments, all at this
Any modifications, equivalent replacements, and improvements etc. done within the spirit and principle of invention, should all be included in the claims in the present invention
Protection scope within.
Claims (3)
1. a kind of method of purification of sodium chloride for injection, which comprises the following steps:
(1) crude salt is dissolved in pure water, obtains the sodium chloride solution of 300g/L, except containing calcium, magnesium, iron and some in the solution
Outside heavy metal ion element, also contain the sodium sulphate of about 2g/L；
(2) sodium chloride solution is filtered using ultrafiltration or micro-filtration, removes larger molecular organics, colloid and the particle in solution；
(3) step (2) water outlet is handled using second level nanofiltration system, two-stage nanofiltration system is used in conjunction, and can effectively remove molten
Sulfate radical in liquid；
(3) nanofiltration system penetrating fluid is pumped into evaporator, is heated in the process using steam, Steam pressure control is in 0.1-
0.15Mpa, in the process, nanofiltration system penetrating fluid are become being saturated from unsaturation, and sodium chloride crystallization is precipitated, while sodium chloride is precipitated
Further purification；
(4) step (3) salt slurry is squeezed into lautertuns, is filtered using traditional micro-filtration or ultra-filtration and separation technique, by sodium chloride
Crystal retention；
(5) salt that filter comes out, which enters in drying bed, is dried, and sufficiently after drying, packs according to medical rank, the product
It can reach the standard of the other injection sodium chloride of pharmaceutical grade, the subsequent salt water that can according to actual needs, prepare various concentration supplies
Hospital patient uses.
2. the method for purification of sodium chloride for injection according to claim 1, which is characterized in that the rate of recovery of first order nanofiltration
It can reach 90%, water inlet of the penetrating fluid of the nanofiltration of the first order as second level nanofiltration, the rate of recovery of second level nanofiltration can reach
95%, overall recovery reaches 85.5%.
3. the method for purification of sodium chloride for injection according to claim 2, which is characterized in that in step (2) and (4), institute
It is polysulfones, polyether sulfone or polyvinylidene fluoride with filter membrane, feeds water pressure < 10bar, the particle that membrane aperture is 0.001-0.1 μm
Son, molecular cut off 1000-30000Da.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910647691.7A CN110451529A (en) | 2019-07-17 | 2019-07-17 | A kind of method of purification of sodium chloride for injection |
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| CN201910647691.7A CN110451529A (en) | 2019-07-17 | 2019-07-17 | A kind of method of purification of sodium chloride for injection |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111362471A (en) * | 2020-04-17 | 2020-07-03 | 莱特莱德（北京）环境技术股份有限公司 | Device for removing sodium sulfate in coal chemical industry byproduct sodium chloride saturated solution |
| CN112374674A (en) * | 2020-09-18 | 2021-02-19 | 安徽普朗膜技术有限公司 | Industrial waste salt treatment system and process |
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|---|---|---|---|---|
| US20070189945A1 (en) * | 2006-01-12 | 2007-08-16 | Thorsten Kopp | Method for the treatment of salt brine |
| CN101659424A (en) * | 2009-09-04 | 2010-03-03 | 广东光华化学厂有限公司 | Method for recovering reagent grade sodium chloride from lime milk production waste liquid |
| US20150352498A1 (en) * | 2011-08-17 | 2015-12-10 | Ahilan RAMAN | Process and system for producing sodium chloride brine |
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| CN104326590A (en) * | 2014-11-28 | 2015-02-04 | 王博 | Method and device for making salt by using seawater |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111362471A (en) * | 2020-04-17 | 2020-07-03 | 莱特莱德（北京）环境技术股份有限公司 | Device for removing sodium sulfate in coal chemical industry byproduct sodium chloride saturated solution |
| CN112374674A (en) * | 2020-09-18 | 2021-02-19 | 安徽普朗膜技术有限公司 | Industrial waste salt treatment system and process |
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