CN110432494A - Probiotic composition and the application for preventing and treating infant's allergic eczema and/or diarrhea - Google Patents
Probiotic composition and the application for preventing and treating infant's allergic eczema and/or diarrhea Download PDFInfo
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- CN110432494A CN110432494A CN201810415856.3A CN201810415856A CN110432494A CN 110432494 A CN110432494 A CN 110432494A CN 201810415856 A CN201810415856 A CN 201810415856A CN 110432494 A CN110432494 A CN 110432494A
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- probiotic composition
- diarrhea
- infant
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
- A23V2400/175—Rhamnosus
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/51—Bifidobacterium
- A23V2400/531—Lactis
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The present invention provides a kind of prevention and treatment infant's allergic eczema and/or the probiotic compositions and preparation method and application of diarrhea.The probiotic composition is prepared from the following components according to parts by weight: 0.2-1 parts of Lactobacillus rhamnosus HN001；0.4-1.5 parts of bifidobacterium lactis HN019；45-55 parts of resistant dextrin；35-45 parts of galactooligosaccharide；5-12 parts of oligofructose；The viable count of the Lactobacillus rhamnosus HN001 is 4.0 × 1011‑5.0×1011The viable count of CFU/g, the bifidobacterium lactis HN019 are 2.5 × 1011‑3.5×1011CFU/g.The probiotic composition of prevention and treatment infant allergic eczema and/or diarrhea and the food being prepared by it, in good taste, nutritional ingredient is easy to absorb, and can significantly reduce the incidence of infant's allergic eczema and diarrhea.
Description
Technical field
The present invention relates to field of functional food, and in particular to a kind of prevention and treatment infant allergic eczema and/or diarrhea
Probiotic composition and application.
Background technique
Allergic eczema is a kind of common inflammatory dermatoses, and clinical characters are pleomorphism fash, and tendency exudation is right
Claim distribution, conscious violent itching, the state of an illness easily symptoms such as repeatedly.In recent years, the case that infant suffers from allergic eczema increases year by year,
And along with serious symptom of diarrhea, the growth and development of infant is seriously affected.Wherein, hair of the milk protein allergy in infancy
Sick rate is 1.9%-5.2%, and the most common symptom is eczema, diarrhea, vomiting.It studies a kind of for preventing and treating infant's milk protein
The product of allergic eczema, is of great practical significance.
Summary of the invention
Based on this, the object of the present invention is to provide a kind of probiotic composition, which can be effectively prevented
Infant's allergic eczema and/or diarrhea.
To achieve the above object, specific technical solution is as follows:
A kind of probiotic composition is prepared from the following components according to parts by weight:
The viable count of the Lactobacillus rhamnosus HN001 is 4.0 × 1011-5.0×1011CFU/g, the bifidobacterium lactis
The viable count of HN019 is 2.5 × 1011-3.5×1011CFU/g。
In wherein some embodiments, the probiotic composition is prepared from the following components according to parts by weight:
In wherein some embodiments, the probiotic composition is prepared from the following components according to parts by weight:
In wherein some embodiments, the probiotic composition is prepared from the following components according to parts by weight:
In wherein some embodiments, the viable count of the Lactobacillus rhamnosus HN001 is 4.5 × 1011CFU/g, it is described
The viable count of bifidobacterium lactis HN019 is 3 × 1011CFU/g。
The present invention also provides the preparation methods of above-mentioned probiotic composition.
Specific technical solution is as follows:
A kind of preparation method of above-mentioned probiotic composition, comprising the following steps: take the Lactobacillus rhamnosus
HN001, bifidobacterium lactis HN019, resistant dextrin, galactooligosaccharide and oligofructose, each component are separately dried, are sieved, mix
Uniformly to get.
In wherein some embodiments, the temperature of the drying is 50-70 DEG C, and the drying is that drying is low to moisture content
In 3%.
In wherein some embodiments, the mesh number of the sieving is 50-70 mesh.
The present invention also provides the applications of above-mentioned probiotic composition.
Specific technical solution is as follows:
Application of the above-mentioned probiotic composition in the health food of preparation prevention and treatment infant's allergic eczema.
Application of the above-mentioned probiotic composition in the health food of preparation prevention and treatment infant's allergic diarrhea.
The present invention also provides a kind of prevention and treatment infant's allergic eczema and/or the health foods of diarrhea.
Specific technical solution is as follows:
A kind of health food for preventing and treating infant's allergic eczema and/or diarrhea is wet by above-mentioned prevention and treatment infant anaphylaxis
Acceptable auxiliary material or additive are prepared in the probiotic composition and health food of rash and diarrhea.
In wherein some embodiments, it is described prevention and treatment infant's allergic eczema and/or diarrhea health food be lozenge,
Chewable tablets or solid beverage.
The probiotic composition of prevention and treatment infant's allergic eczema and/or diarrhea of the invention and application have the following advantages that
With the utility model has the advantages that
The present invention passes through a large amount of creative works of inventor, using Lactobacillus rhamnosus HN001, bifidobacterium lactis HN019
Cooperation, while for supplementing beneficial bacteria of intestinal tract promote intestinal beneficial bacterium growth and breeding, inhibit the growth of pathogenic bacteria, and
Promoting immunologic cellular activity, killing causes the growth of the pathogenic bacteria of diarrhea, can be used for preventing and treating infant's allergic eczema, diarrhea,
Improve infant's intestinal microbial balance, significantly improves infant eczema symptom, symptom of diarrhea.Galactooligosaccharide, oligofructose,
Resistant starch can improve functions of intestines and stomach as prebiotics, and be conducive to Lactobacillus rhamnosus HN001 and bifidobacterium lactis
The addition of field planting of the HN019 in enteron aisle, these prebiotics has the function of synergy, can significantly improve rhamnose cream bar
The effect of bacterium HN001 and bifidobacterium lactis HN019 prevention and treatment infant's allergic eczema and diarrhea, and composition can be improved
Mouthfeel.Found by the proportion of further preferred each component, only Lactobacillus rhamnosus HN001 and bifidobacterium lactis HN019 with
Galactooligosaccharide, oligofructose, resistant starch, five are cooperated (Lactobacillus rhamnosus HN001, cream pair at a specific ratio
Proportion between the content of discrimination bacillus HN019 and the total amount of prebiotics needs to control in OK range, and three kinds of prebiotics
Between proportion be also required to control in OK range), and the number of viable in control composition could be obtained and significantly be controlled
The effect of infant eczema symptom and symptom of diarrhea is treated,
The probiotic composition of prevention and treatment infant's allergic eczema and/or diarrhea of the invention and the food being prepared by it
Product, in good taste, nutritional ingredient is easy to absorb, and the incidence of infant's allergic eczema and diarrhea can be significantly reduced.And its
Preparation method is simple, easy to operate, is suitble to industrialized production.
Detailed description of the invention
Fig. 1 is the probiotic composition of embodiment 1 to the therapeutic effect figure of allergic eczema infant, and wherein A is treatment
Preceding state, B are the state after treatment.
Fig. 2 is influence of the probiotic composition of different formulations ratio to allergic eczema infant excrement enteric microorganism
Result figure, wherein BA corresponding embodiment 1, CA correspond to comparative example 4, and JA corresponds to comparative example 5, and LA corresponds to comparative example 2, and KA is to reply
Ratio 1, FA correspond to comparative example 3..
Specific embodiment
Below in conjunction with specific embodiment to the probiotic combinations of prevention and treatment infant's allergic eczema and/or diarrhea of the invention
Object and application are further described in detail.
Embodiment 1 and comparative example 1-5
By the prevention and treatment infant allergic eczema and/or abdomen of the preparation embodiment 1 and comparative example 1-5 of formula composition shown in table 1
The probiotic composition rushed down.
1 probiotic composition component proportion (according to parts by weight) of table
| Embodiment 1 | Comparative example 1 | Comparative example 2 | Comparative example 3 | Comparative example 4 | Comparative example 5 | |
| Lactobacillus rhamnosus HN001 | 0.56 | 0.56 | 0.56 | 0.56 | 0.56 | 0.56 |
| Bifidobacterium lactis HN019 | 0.83 | 0.83 | 0.83 | 0.83 | 0.83 | 0.83 |
| Resistant dextrin | 50.61 | 50.61 | 50.61 | 0 | 75.9 | 25.3 |
| Galactooligosaccharide | 40.00 | 46.00 | 30.00 | 82.18 | 60 | 20 |
| Oligofructose | 8.00 | 2.00 | 18.00 | 16.40 | 12 | 4 |
Wherein the viable count of Lactobacillus rhamnosus HN001 is 4.5 × 1011CFU/g, the viable count of bifidobacterium lactis HN019
It is 3 × 1011CFU/g。
The preparation method is as follows:
Each material is weighed by formula rate, dries under the conditions of 60 DEG C to its moisture content be lower than 3% respectively, crosses 60 mesh
Sieve is uniformly mixed to get probiotic composition.
The probiotic composition can be prepared into solid beverage, chewable tablets or lozenge by common process in industry.
The effect of 2 probiotic composition of embodiment treatment infant's allergic eczema and diarrhea
(1) clinical test and administration
Selecting clinical diagnosis is infant's case 70 of milk protein allergic eczema, and the age is -3 years old 6 months, at random
It is divided into 7 groups, substitutes single regular convention formula milk powder with probiotic composition of the invention+regular convention formula milk powder and meals are carried out to patient
Food therapy is treated 1 month, and observation probiotic composition joint regular convention formula milk powder is to the improvement situation of infant eczema symptom and right
The influence of excrement intestinal flora.Wherein, test group is divided into 6 groups, and probiotic composition used respectively corresponds embodiment 1, comparative example
The probiotic composition of 1-5 preparation, every group of 10 people.Blank control group infant daily single regular convention formula milk powder, with
37 DEG C of warm boiled waters (ratio is 37.5g milk powder: 240mL warm water)；Test group uses embodiment 1, comparative example 1-5 made daily
Standby probiotic composition combines regular convention formula milk powder, and with 37 DEG C of warm boiled waters, (ratio is 1.5g probiotic composition: 36g
Milk powder: 240mL warm water).
(2) apparent state observation
After the probiotic composition of observation the embodiment of the present invention 1 is intervened 1 month, before and after the apparent symptom of infant eczema
Variation.
(3) clinical efficacy measures
The simultaneous phenomenons such as eczema and diarrhea completely disappear as special efficacy after treatment；The simultaneous phenomenons such as eczema and diarrhea improve to have
Effect；It is invalid that the simultaneous phenomenons such as eczema and diarrhea, which do not improve, after treatment；It defecates after treatment dilute, bowel frequency > 3 time are not tolerate.It is right
The probiotic composition does not tolerate, does not like taste, eczema or the simultaneous phenomenon of formula without improvement, to be not suitable for.
(4) influence of the probiotic composition to infant's intestinal flora
Patients before and after intervention collects infant's excrement, packing, and carries out liquid nitrogen flash freezer to sample, and then fast transfer is to -80 DEG C
Refrigerator saves.Infant's fecal sample is sent to company carry out as early as possible by the method being sequenced by 16S rRNA microbial diversity
Sequencing, analyzes the variation of different groups of infant's intestinal flora species diversities.
(5) result: (wherein A is to control as shown in Figure 1 for the apparent state diagram of the probiotic composition intervention effect of embodiment 1
State before treatment, B are the state after treatment)；Allergic eczema infant patient intestinal flora species distribution thermal map such as Fig. 2 institute
Show.Clinical efficacy measurement result is as shown in table 2.
Can intuitively it be found out by Fig. 1, the probiotic composition in embodiment 1 imitates the treatment of allergic eczema infant
Fruit is significant, can significantly improve infant's epidermis eczema phenomenon.
As seen from Figure 2, genus lactubacillus is as a kind of probiotics, example 1 group (BA) average relative abundance most
High (18.88%), followed by 5 groups of comparative example (JA) (6.01%), 2 groups of comparative example (LA) (5.86%), and lactobacillus is right
4 groups of ratio (CA) of average relative abundance is minimum, is 3.96%.It is therefore seen that probiotic composition in embodiment 1 can be compared with
The intestinal flora of good improvement allergic eczema infant, promotes the increase of lactobacillus.
As can be seen from Table 2, the probiotic composition of embodiment 1 is obviously good to the therapeutic effect of allergic eczema infant
In other experimental groups and control group, the probiotic composition of embodiment 1 is spy to the effect of 9 allergic eczema infants
Effect illustrates that eczema and diarrhea and simultaneous phenomenon completely disappear after treating, and only an example is to improve eczema and simultaneous phenomenon, without nothing
Imitate case.The proportion of galactooligosaccharide and oligofructose is improper in comparative example 1 and 2, its therapeutic effect is caused to be worse than embodiment
1.Due to there is no addition resistant dextrin in comparative example 3, its therapeutic effect is caused to be worse than embodiment 1.That adds in comparative example 4 is prebiotic
First excessive (total amount of galactooligosaccharide, oligofructose and resistant dextrin be embodiment 1 1.5 times), the benefit added in comparative example 5
Raw member is very few (total amount of galactooligosaccharide, oligofructose and resistant dextrin be embodiment 1 0.5 times), leads to its treatment effect
Fruit is worse than embodiment.
The intervention of 2 probiotic composition of table is to allergic eczema infant's result
Each technical characteristic of embodiment described above can be combined arbitrarily, for simplicity of description, not to above-mentioned reality
It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, all should be considered as described in this specification.
The embodiments described above only express several embodiments of the present invention, and the description thereof is more specific and detailed, but simultaneously
It cannot therefore be construed as limiting the scope of the patent.It should be pointed out that coming for those of ordinary skill in the art
It says, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to protection of the invention
Range.Therefore, the scope of protection of the patent of the invention shall be subject to the appended claims.
Claims (10)
1. a kind of probiotic composition, which is characterized in that according to parts by weight, be prepared from the following components:
The viable count of the Lactobacillus rhamnosus HN001 is 4.0 × 1011-5.0×1011CFU/g, the bifidobacterium lactis HN019
Viable count be 2.5 × 1011-3.5×1011CFU/g。
2. probiotic composition according to claim 1, which is characterized in that according to parts by weight, prepared by following components
It forms:
3. probiotic composition according to claim 2, which is characterized in that according to parts by weight, prepared by following components
It forms:
4. probiotic composition according to claim 1-3, which is characterized in that the Lactobacillus rhamnosus
The viable count of HN001 is 4.5 × 1011The viable count of CFU/g, the bifidobacterium lactis HN019 are 3 × 1011CFU/g。
5. a kind of preparation method of the described in any item probiotic compositions of claim 1-4, which is characterized in that including following step
It is rapid: to take the Lactobacillus rhamnosus HN001, bifidobacterium lactis HN019, resistant dextrin, galactooligosaccharide and oligofructose, each group
Be separately dried, be sieved, be uniformly mixed to get.
6. preparation method according to claim 5, which is characterized in that the temperature of the drying is 50-70 DEG C, the drying
It is lower than 3% for drying to moisture content；And/or the mesh number of the sieving is 50-70 mesh.
7. the described in any item probiotic compositions of claim 1-4 are in the health food of preparation prevention and treatment infant's allergic eczema
In application.
8. the described in any item probiotic compositions of claim 1-4 are in the health food of preparation prevention and treatment infant's allergic diarrhea
In application.
9. the health food of a kind of prevention and treatment infant's allergic eczema and/or diarrhea, which is characterized in that appointed by claim 1-4
Acceptable auxiliary material or additive are prepared in probiotic composition described in one and health food.
10. the health food of prevention and treatment infant's allergic eczema according to claim 9 and/or diarrhea, which is characterized in that
The health food is lozenge, chewable tablets or solid beverage.
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Cited By (7)
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| CN110810518A (en) * | 2019-11-28 | 2020-02-21 | 海南国健高科技乳业有限公司 | Composite probiotic solid beverage and preparation method thereof |
| CN111264739A (en) * | 2020-03-31 | 2020-06-12 | 广州纽缤乐营养科技股份有限公司 | Probiotic solid beverage and preparation method thereof |
| CN111387503A (en) * | 2020-05-20 | 2020-07-10 | 宋培洋 | Milk powder mate for infants and preparation method thereof |
| CN111528486A (en) * | 2020-05-19 | 2020-08-14 | 仙乐健康科技股份有限公司 | Composition containing lactoferrin |
| CN111955740A (en) * | 2020-08-12 | 2020-11-20 | 量子高科(中国)生物股份有限公司 | Composition for relieving and treating atopic dermatitis and application thereof |
| CN114390897A (en) * | 2021-10-29 | 2022-04-22 | 海普诺凯营养品有限公司 | A kind of composition of prebiotic and probiotic and application thereof |
| CN114401728A (en) * | 2021-10-29 | 2022-04-26 | 海普诺凯营养品有限公司 | Composition of prebiotics and probiotic compound and application thereof |
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| CN111264739A (en) * | 2020-03-31 | 2020-06-12 | 广州纽缤乐营养科技股份有限公司 | Probiotic solid beverage and preparation method thereof |
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| CN114401728B (en) * | 2021-10-29 | 2024-05-31 | 澳优乳业（中国）有限公司 | Composition of prebiotics and probiotics compound and application thereof |
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