CN110338792B - Ovarian epithelial malignant tumor detection device - Google Patents

Abstract

The invention discloses an ovarian epithelial malignant tumor detection device, which comprises a tunable terahertz source, a first optical fiber, a polarization spectroscope, a confocal lens, a plano-convex lens, a window, a reflecting mirror, a second optical fiber, a terahertz spectrometer and a computer, wherein the tunable terahertz source is arranged on the surface of the tunable terahertz source; the optical input end of the first optical fiber is connected with the optical output end of the tunable terahertz source, and the optical output end of the first optical fiber is connected with the optical input end of the polarization spectroscope; the optical input end of the second optical fiber is connected with the optical output end of the reflecting mirror, and the optical output end of the second optical fiber is connected with the optical input end of the terahertz spectrometer; and the data output end of the terahertz spectrometer is connected with the data input end of the computer through a cable. The detection device provided by the invention adopts the tunable terahertz source as the emission source, and the terahertz waves are focused on the surface of the ovary for detection through the combination of the lenses, so that the detection device has low requirements on the detection operation environment, has no side effect on human bodies, and has high accuracy of detection results.

Description

Ovarian epithelial malignant tumor detection device

technical field

The invention relates to the technical field of medical devices, in particular to a detection device for ovarian epithelial malignant tumors.

Background technique

Ovarian epithelial malignant tumor is a common gynecological tumor disease, with no obvious symptoms in the early stage, and mostly in the late stage when it is clearly diagnosed, with a high mortality rate. Early detection of ovarian epithelial malignant tumors is conducive to timely and correct treatment, reducing the mortality of patients.

At present, the detection methods for ovarian epithelial malignant tumors mainly include ultrasound detection, CT imaging and nuclear magnetic resonance. Among them, ultrasonic diagnosis can determine the size, shape and tumor growth site of ovarian epithelial tumors, but the nature of the tumor cannot be judged, and for early tumors with small volumes, ultrasonic diagnosis cannot distinguish; CT imaging can determine the nature of tumors to a certain extent. Judgment, but the source of CT is X-rays, long-term use has certain side effects on the human body; nuclear magnetic resonance has a high resolution for tumor detection, but the operation time is long, and it must be used in a specific environment to avoid metal damage. Detection interference, high detection cost.

Contents of the invention

The purpose of the present invention is to overcome the shortcomings of the above-mentioned background technology and provide a detection device for ovarian epithelial malignant tumors. The device uses a tunable terahertz source as the emission source, and focuses the terahertz wave to the surface of the ovary for detection through a combination of multiple lenses. , not only has low requirements for the operating environment of the detection, but also has no side effects on the human body, and the detection results are highly accurate.

In order to achieve the above object, the present invention provides a detection device for malignant ovarian epithelial tumors, comprising a tunable terahertz source, a first optical fiber, a polarizing beam splitter, a confocal lens, a plano-convex lens, a window, a mirror, a second optical fiber, a Hertz spectrometer and computer;

The optical input end of the first optical fiber is connected to the optical output end of the tunable terahertz source, the optical output end of the first optical fiber is connected to the optical input end of the polarization beam splitter; the optical input end of the second optical fiber is connected to the The optical output end of the reflector is connected, the optical output end of the second optical fiber is connected with the optical input end of the terahertz spectrometer; the data output end of the terahertz spectrometer is connected with the data input end of the computer through a cable;

The terahertz waves emitted by the tunable terahertz source pass through the first optical fiber, then pass through the polarizing beam splitter, confocal lens, plano-convex lens, and window in sequence, and then pass through the patient's skin and focus to the surface of the ovary; reflected by the surface of the ovary The final terahertz wave is transmitted sequentially and then reversely passes through the window, plano-convex lens, and confocal lens, and then is transmitted to the reflector by the polarizing beam splitter through 90° refraction, and then transmitted to the terahertz spectrometer after being reflected by the reflector; the terahertz wave The spectrometer transmits the received terahertz wave data to a computer, and the computer is used for frequency domain and time domain analysis on the received data signal.

Further, it also includes a first guide rail, and the first guide rail extends along the arrangement direction of the polarization beam splitter, the confocal lens, the plano-convex lens, and the window; the polarization beam splitter is installed on the first guide rail through the first bracket, so The confocal lens is installed on the first guide rail through the second bracket, the plano-convex lens is installed on the first guide rail through the third bracket, and the window is installed on the first guide rail through the fourth bracket.

Further, the bottom of the third bracket is provided with a slider, and the slider is embedded on the first guide rail and slidably connected thereto.

Further, it also includes a second guide rail, and the reflector is mounted on the second guide rail through a fifth bracket.

Further, the second guide rail is vertically arranged to the first guide rail.

Still further, the frequency range of the tunable terahertz source is 0.3-20 THz.

Furthermore, the frequency range of the tunable terahertz source is 1.5-10 THz.

Compared with prior art, the present invention has following advantage:

First, the present invention uses a tunable terahertz source as the detection source, and the emitted terahertz wave is between microwave and infrared wave, which has strong penetrability, low photon energy, non-ionization, strong penetrability, etc. Features: The radiation energy to the human body is 1 million times smaller than that of X-rays. Using terahertz waves to detect ovarian epithelial malignant tumors has no side effects on the human body. It can accurately detect its size and location, and make a certain judgment on the nature of the tumor. It is ovarian epithelial malignant tumor It provides an important reference for the early diagnosis and treatment of tumors.

Second, the present invention is designed with polarizing beam splitters, confocal lenses, plano-convex lenses, and reflectors to build a transmission line for terahertz waves. Terahertz waves can be emitted in a directional manner, and the scanning resolution can reach the micron level, and small volumes can be identified. Tumor cells are beneficial to the early detection of ovarian epithelial malignant tumors. In addition, terahertz waves can directly penetrate common clothing, and the use of terahertz waves to scan the pelvic cavity is easy to operate and is suitable for rapid clinical detection.

Thirdly, the focused spot of the terahertz wave in the present invention can reach 100 microns, and the scanning resolution is better than that of common ultrasonic scanning, and the confocal lens can directly eliminate the signal interference between the surface of the ovary and the terahertz emission source, improving the detection accuracy.

Description of drawings

1 is a schematic structural view of a detection device for ovarian epithelial malignant tumors;

In the figure: tunable terahertz source 1, first optical fiber 2, polarization beam splitter 3, confocal lens 4, plano-convex lens 5, window 6, mirror 7, second optical fiber 8, terahertz spectrometer 9, computer 10, cable 11. The first guide rail 12, the first support 13, the second support 14, the third support 15, the fourth support 16, the slider 17, the second guide rail 18, the fifth support 19, the skin 20, and the ovary 21.

Detailed ways

The implementation of the present invention will be described in detail below in conjunction with the examples of implementation, but they do not constitute a limitation of the present invention, and are only examples. At the same time, the advantages of the present invention will become clearer and easier to understand.

A detection device for malignant ovarian epithelial tumors as shown in Figure 1, including a tunable terahertz source 1, a first optical fiber 2, a polarizing beam splitter 3, a confocal lens 4, a plano-convex lens 5, a window 6, a mirror 7, a first Two optical fibers 8, a terahertz spectrometer 9, and a computer 10; the tunable terahertz source 1 can emit terahertz waves. In this implementation, the manufacturer of the tunable terahertz source 1 is RAINBOW PHOTONICS, the model is TeraTune, and its frequency is 0.3 It is continuously adjustable within ~20THz, preferably the frequency is continuously adjustable within 1.5 ~ 10THz. The manufacturer of polarizing beam splitter 3 is THORLABS, model: VA5-1550. The manufacturer of confocal lens 4 is LENSTEK LASER OPTICS, model: CLS-F70; the manufacturer of plano-convex lens 5 is THORLABS, model: N-BK7; the manufacturer of window 6 is THORLABS, model: WG71050; the manufacturer of terahertz spectrometer 9 The manufacturer is THORLABS, model: TERA-ASOPS. The optical input end of the first optical fiber 2 is connected to the optical output end of the tunable terahertz source 1, and the optical output end of the first optical fiber 2 is connected to the optical input end of the polarization beam splitter 3; the optical input end of the second optical fiber 8 is connected to the reflection The optical output end of the mirror 7 is connected, and the optical output end of the second optical fiber 8 is connected with the optical input end of the terahertz spectrometer 9; the data output end of the terahertz spectrometer 9 is connected with the data input end of the computer 10 through a cable 11; the confocal lens 4 is arranged between the polarizing beam splitter 3 and the plano-convex lens 5; the plano-convex lens 5 is arranged between the confocal lens 4 and the window 6, and the polarizing beam splitter 3, the confocal lens 4, the plano-convex lens 5, and the window 6 are located on the same horizontal line superior.

In the above technical solution, it also includes a first guide rail 12 and a second guide rail 18, the first guide rail 12 extends along the arrangement direction of the polarization beam splitter 3, the confocal lens 4, the plano-convex lens 5, and the window 6; the polarization beam splitter 3 passes through the first A bracket 13 is installed on the first guide rail 12, the confocal lens 4 is installed on the first guide rail 12 through the second bracket 14, the plano-convex lens 5 is installed on the first guide rail 12 through the third bracket 15, and the window 6 passes through the fourth bracket 16 is installed on the first guide rail 12. The bottom of the third bracket 15 is provided with a slide block 17 , which is embedded on the first guide rail 12 and slidably connected thereto. The reflector 7 is installed on the second guide rail 18 through the fifth bracket 19 , and the second guide rail 18 is vertically arranged with the first guide rail 12 .

In the above technical solution, the terahertz waves emitted by the tunable terahertz source 1 pass through the first optical fiber 2, then pass through the polarizing beam splitter 3, the confocal lens 4, the plano-convex lens 5, and the window 6 in sequence, and then pass through the patient's skin 20 Focus on the surface of the ovary 21; first adjust the initial frequency of the terahertz wave of the tunable terahertz source 1, take the surface of the patient's skin 20 as the initial focus point of the window 6, and then adjust the plano-convex lens 5 to slide along the first guide rail 12 until the The terahertz waves are focused to the surface of the ovary 21 . The terahertz wave reflected by the surface of the ovary 21 is transmitted sequentially and then reversely passes through the window 6, the plano-convex lens 5, and the confocal lens 4, and then is transmitted to the mirror 7 by the polarizing beam splitter 3 through 90° refraction, and then reflected by the mirror 7 Afterwards, it is transmitted to the terahertz spectrometer 9; then, it is scanned point by point to cover the entire ovarian surface to complete a scanning cycle; the frequency of the terahertz wave is adjusted to perform the next scanning cycle; the frequency of the terahertz wave is continuously tuned so that each scanning cycle produces a corresponding 0.3- Broadband reflection signal at 20THz frequency. The terahertz spectrometer 9 transmits the received terahertz wave data to the computer 10, and the computer 10 is used for frequency domain and time domain analysis on the received data signal. By analyzing the time-domain signal reflection intensity and frequency-domain signal characteristic peaks of tumor cells, the location, size and nature of tumors on the surface of the ovary can be judged in real time.

Since the surface of the ovary is about tens of millimeters below the skin, terahertz waves are between microwave and infrared waves, and have strong penetrability. After focusing, the spot can reach 100 microns, and the scanning resolution is better than common ultrasonic scanning; and adopt The confocal lens directly excludes signal interference between the surface of the ovary and the source of the terahertz emission. Compared with normal cells, the metabolism of tumor cells on the surface of the ovary is faster, the cell density changes and the exchange of substances inside and outside the cells accelerates, and there are abundant new blood vessels distributed around and inside the tumor cells. Terahertz waves are very sensitive to polar molecules, etc., and can directly obtain molecular fingerprint information with the structure and properties of reactive substances. Therefore, the normal ovarian surface and the tumor area can be distinguished through the changes in the intensity and phase of the terahertz wave reflected from the surface of the ovary, and the position and size of the tumor cells can be obtained through continuous scanning. In addition, by comparing the difference in frequency-domain signals of terahertz waves reflected by benign tumors and malignant tumors, the nature of tumors on the surface of the ovary can be judged, providing early reference for further pathological diagnosis of tumors. There are no special requirements for the detection operating environment and no side effects on the human body. Especially in the early stage of tumor formation, that is, when the size is small, it can accurately detect its size and location, and make a certain judgment on the nature of the tumor. It is an early diagnosis of ovarian epithelial malignant tumors. and treatment provide an important reference.

The above is only a specific embodiment of the present invention. It should be pointed out that any changes or substitutions that can be easily conceived by those skilled in the art within the technical scope disclosed in the present invention shall be covered by the protection scope of the present invention. , and the rest not specified are prior art.

Claims (3)

1. A detection device for malignant ovarian epithelial tumors, characterized in that: comprising a tunable terahertz source (1), a first optical fiber (2), a polarizing beam splitter (3), a confocal lens (4), a plano-convex lens (5 ), window (6), mirror (7), second optical fiber (8), terahertz spectrometer (9) and computer (10); Between the convex lenses (5); the plano-convex lens (5) is arranged between the confocal lens (4) and the window (6), the polarization beam splitter (3), the confocal lens (4), the plano-convex lens (5), Window (6) is located on the same horizontal straight line; The optical input end of the first optical fiber (2) is connected to the optical output end of the tunable terahertz source (1), the optical output end of the first optical fiber (2) is connected to the optical input end of the polarization beam splitter (3) Connect; the optical input end of the second optical fiber (8) is connected with the optical output end of the mirror (7), and the optical output end of the second optical fiber (8) is connected with the optical input end of the terahertz spectrometer (9) The data output end of described terahertz spectrometer (9) is connected with the data input end of computer (10) by cable (11); The terahertz wave emitted by the tunable terahertz source (1) passes through the first optical fiber (2) and then sequentially passes through the polarization beam splitter (3), the confocal lens (4), the plano-convex lens (5), the window (6 ), and then pass through the patient's skin (20) and focus to the surface of the ovary (21); the terahertz wave reflected by the surface of the ovary (21) is transmitted in turn and then reversely passes through the window (6), plano-convex lens (5), common The focusing lens (4) is then transmitted to the reflector (7) by the polarizing beam splitter (3) through 90° refraction, and then transmitted to the terahertz spectrometer (9) after being reflected by the reflector (7); the terahertz spectrometer ( 9) Conducting the received terahertz wave data to a computer (10), the computer (10) is used for frequency domain and time domain analysis of the received data signal; the frequency range of the tunable terahertz source (1) 0.3~20THz; It also includes a first guide rail (12), and the first guide rail (12) extends along the arrangement direction of the polarization beam splitter (3), the confocal lens (4), the plano-convex lens (5), and the window (6); The polarizing beam splitter (3) is installed on the first guide rail (12) by the first bracket (13), and the confocal lens (4) is installed on the first guide rail (12) by the second bracket (14). The plano-convex lens (5) is installed on the first guide rail (12) by the third support (15), and the window (6) is installed on the first guide rail (12) by the fourth support (16); It also includes a second guide rail (18), and the reflector (7) is installed on the second guide rail (18) by a fifth bracket (19); the second guide rail (18) is perpendicular to the first guide rail (12) layout. 2. The ovarian epithelial malignant tumor detection device according to claim 1, characterized in that: a slider (17) is provided at the bottom of the third support (15), and the slider (17) is embedded in the first It is slidingly connected with it on the guide rail (12). 3. The ovarian epithelial malignant tumor detection device according to claim 2, characterized in that: the frequency range of the tunable terahertz source (1) is 1.5-10 THz.

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