CN110301939A - Imaging of tissue and parameter detecting system - Google Patents

Abstract

The invention relates to a tissue imaging and parameter detection system, which includes an imaging and parameter detection unit and a probe connected thereto, and the imaging and parameter detection unit includes: a tissue parameter detection module for generating and processing tissue parameter detection signals according to control instructions The imaging module is used to generate and process imaging signals according to control instructions; the control module is connected to the tissue parameter detection module, the imaging module and the probe, and is used to control the probe to enter the tissue parameter detection mode or imaging mode , and send a control instruction to the tissue parameter detection module or the imaging module. The control module controls the tissue parameter detection mode or the conversion of the imaging mode. After the imaging mode is used to locate the best position, switch to the control tissue parameter detection mode to start the elastic detection function and realize the elastic detection.

Description

Tissue Imaging and Parameter Detection System

technical field

The invention relates to medical detection, in particular to a tissue imaging and parameter detection system with image guidance function.

Background technique

The development of various chronic diseases, such as viral hepatitis (hepatitis A, hepatitis B, hepatitis C, etc.), will be accompanied by fibrosis of damaged tissues, and the process of tissue fibrosis will be accompanied by changes in tissue elasticity. Therefore, tissue elasticity information is a parameter that can be used to diagnose the degree of tissue fibrosis.

Transient Elastography (TE) is a technique for quantitatively detecting tissue elastic modulus, which can comprehensively reflect the degree of tissue fibrosis by measuring the liver stiffness measurement (LSM).

However, the transient elastography technique cannot obtain the tissue structure information of the detection area, especially the two-dimensional structure information of the tissue, and technicians usually can only set and arrange the ultrasonic probe for transient elastography based on experience. Therefore, when performing elasticity detection, if there are large blood vessels, cysts, or ascites in the area to be detected that will affect the accuracy of the elasticity detection results, detection errors will be unavoidable.

Contents of the invention

Based on this, it is necessary to provide a tissue imaging and parameter detection system for the problem that the transient elastography technique cannot avoid detection errors.

A tissue imaging and parameter detection system, including an imaging and parameter detection unit and a probe connected thereto, the imaging and parameter detection unit includes: a tissue parameter detection module, used to generate and process tissue parameter detection signals according to control instructions; the imaging module , used to generate and process imaging signals according to control instructions; a control module, connected to the tissue parameter detection module, the imaging module and the probe, used to control the probe to enter the tissue parameter detection mode or imaging mode, and send The tissue parameter detection module or the imaging module sends control instructions.

In one of the embodiments, the control module includes a switch control submodule, and the switch control submodule is used to control the probe to switch between the tissue parameter detection mode and the imaging super mode.

In one of the embodiments, the switching control submodule includes a transfer switch, and the transfer switch is used to connect the parameter detection module or the imaging module with the probe.

In one of the embodiments, the parameter detection module includes a first control processor and a shear wave driver, and the first control processor is connected to the control module and the shear wave driver respectively; the first The control processor is used to generate a first excitation signal according to the control instruction, and transmit the first excitation signal to the shear wave driver; the shear wave driver is used to receive the first excitation signal, and perform Amplifying processing, transmitting the amplified first excitation signal to the probe, and exciting the probe to generate low-frequency shear wave.

In one of the embodiments, the tissue parameter detection module further includes a first signal transmitter, the first signal transmitter is connected to the first control processor, and the first control processor transmits a second excitation signal , and transmit to the first signal transmitter, and the first signal transmitter transmits the second excitation signal to the probe to drive the probe to generate an ultrasonic signal.

In one of the embodiments, the tissue parameter detection module further includes a first analog-to-digital converter and a first signal amplifier, and the first control processor is sequentially connected to the first analog-to-digital converter and the first signal amplifier After the echo signal detected by the probe is amplified by the first signal amplifier, the analog signal is converted into a digital signal by the first analog-to-digital converter and then transmitted to the first control processor.

In one of the embodiments, the probe includes a shear wave generator, a pressure detector and a transducer array, the shear wave generator is used to generate low-frequency shear waves, and the pressure detector is a pressure sensor or a displacement sensor. The sensor is used to detect the pressure of the probe on its contact part, and the transducer array is used for acoustic-electric signal conversion.

In one of the embodiments, the frequency range of the low-frequency shear wave is: 1-1000 Hz; the amplitude range of the low-frequency shear wave is: 0.1-50 mm.

In one of the embodiments, the imaging frequency range of the probe is: 0.5-50MHz; the imaging frame frequency range of the probe is: 0.1-100000Hz; the imaging depth range of the probe is: 0.1-500mm; The imaging sampling frequency range of the probe is: 1-500MHz.

The above tissue imaging and parameter detection system includes an imaging and parameter detection unit and a probe connected thereto, the imaging and parameter detection unit includes a tissue parameter detection module, an imaging module and a control module, and the tissue parameter detection module is used to generate and Processing tissue parameter detection signals; imaging module, used to generate and process imaging signals according to control instructions; control module, connected with the tissue parameter detection module, the imaging module and the probe, used to control the probe to enter the tissue parameter detection mode or imaging mode, and send control instructions to the tissue parameter detection module or imaging module. The control module controls the tissue parameter detection mode or the conversion of the imaging mode. After the imaging mode is used to locate the best position, switch to the control tissue parameter detection mode to start the elastic detection function and realize the elastic detection.

Description of drawings

Fig. 1 is a block diagram of a tissue imaging and parameter detection system according to an embodiment of the present invention.

Detailed ways

Please refer to FIG. 1 , a tissue imaging and parameter detection system includes an imaging and parameter detection unit 10 and a probe 20 connected thereto. The imaging and parameter detection unit 10 includes: a tissue parameter detection module 110 configured to generate and processing tissue parameter detection signals; imaging module 120, used to generate and process imaging signals according to control instructions; control module 130, connected with the tissue parameter detection module 110, the imaging module 120 and the probe 20, for controlling The probe 20 enters the tissue parameter detection mode or the imaging mode, and sends a control instruction to the tissue parameter detection module 110 or the imaging module 120 .

As shown in FIG. 1 , the tissue parameter detection module 110 is used to generate and process tissue parameter detection signals according to control instructions, and the probe 20 drives the probe 20 according to the first excitation signal transmitted by the tissue parameter detection module 110 to generate Low-frequency shear wave, and then quantitatively detect tissue elastic modulus. The tissue parameter detection module 110 includes a first control processor 111 , a shear wave driver 112 , a first signal amplifier 113 , a first analog-to-digital converter 114 , a first signal transmitter 115 and a pressure detection processor 116 . Wherein the frequency range of the low-frequency shear wave is: 1-1000 Hz; the amplitude range of the low-frequency shear wave is: 0.1-50 mm.

The first control processor 111 is connected to the shear wave driver 112, and the first control processor 111 is configured to generate a first excitation signal according to a control instruction, and transmit the first excitation signal to the shear wave driver 112. The driver 112 , the shear wave driver 112 is configured to receive the first excitation signal, amplify the excitation signal, and transmit the amplified first excitation signal to the probe 20 . The first excitation signal excites the probe 20 to generate low-frequency shear waves. The first control processor 111 is connected to the first signal transmitter 115, the first control processor 111 transmits a second excitation signal, and transmits to the first signal transmitter 115, the first signal The transmitter 115 transmits the high-voltage excitation signal to the probe 20 to drive the probe 20 to generate an ultrasonic signal. The first control processor 111 is sequentially connected to the first analog-to-digital converter 114 and the first signal amplifier 113. After the ultrasonic echo signal detected by the probe 20 is amplified by the first signal amplifier 113, Then the analog signal is converted into a digital signal by the first analog-to-digital converter 114 and then transmitted to the first control processor 111, and the first control processor 111 performs data conversion, processing, and filtering on the received data and so on. The pressure detection processor 116 is connected to the first control processor 111, and the pressure detection processor 116 transmits the pressure value detected by the probe 20 in contact with the contact site to the first control processor 111 , the first control processor 111 transmits the pressure value to the display device for display, which is convenient for users to monitor in real time.

In this embodiment, the first control processor 111 is a field-programmable gate array (Field-Programmable Gate Array: FPGA) board. The FPGA generates a second excitation signal, and the second excitation signal drives the probe 20 to generate an ultrasonic signal. The FPGA sends a first excitation signal, and the first excitation signal is amplified by the shear wave driver 112 , and then the first excitation signal excites the probe 20 to generate a low frequency shear wave. The propagation velocity of the low-frequency shear wave is different in tissues with different hardness, and the ultrasonic signal carries the propagation velocity information of the low-frequency shear wave and is transmitted to the tissue parameter detection module, so as to accurately and quantitatively calculate the tissue hardness.

The imaging module 120 generates and processes imaging signals according to control instructions, and the imaging signals are sent by the probe 20 for precise positioning, and then select a suitable diagnostic position and angle for the tissue parameter detection module 110 to detect. The imaging module 120 includes a second control processor 121, a second signal amplifier 122, a second analog-to-digital converter 123, and a second signal transmitter 124, and the second control processor 121 and the second signal transmitter 124 connection, the second control processor 121 sends a driving pulse to the second signal transmitter 124, and the second signal transmitter 124 transmits the driving pulse to the probe 20 to drive the probe 20 to generate an ultrasonic signal . The second control processor 121 is sequentially connected with the second analog-to-digital converter 123 and the second signal amplifier 122, and is used for processing the ultrasonic echo signal, that is, receiving the ultrasonic echo signal detected by the probe 20, and passing through the second The second signal amplifier 122 performs signal amplification, and then the analog signal is converted into a digital signal by the second analog-to-digital converter 123 and then transmitted to the second control processor 121 .

In this embodiment, the second control processor 121 is a field-programmable gate array (Field-Programmable Gate Array: FPGA) board. Of course, according to design requirements, the first control processor 111 and the second control processor 121 can be any one of STM32 single-chip microcomputer and ARM chip, as long as it can realize data processing, control its connected devices, and send the first / The second excitation signal is sufficient.

The control module 130 is configured to process the tissue parameter detection signal and the imaging signal, and control the probe 20 to perform tissue parameter detection mode detection or imaging mode detection according to the tissue parameter detection signal and the imaging signal. The control module 130 includes a switching control sub-module 131 and a probe switching unit 132. The probe switching unit 132 is connected to the probe 20 and can output signal pulses to the probe 20, and at the same time realize different detection objects (detection of the liver, chest cavity, etc.) body part), the switching of the probe 20, the switching control sub-module 131 is used to control the switching of the probe 20 between the tissue parameter detection mode and the imaging mode. The switching control sub-module 131 includes a switch, and the switch is used to connect the parameter detection module or the imaging module with the probe. .

The probe 20 includes a shear wave generator 210, a pressure detector 220, and a transducer 230. The shear wave generator 210 is driven by the first excitation signal generated by the tissue parameter detection module 110 to generate low-frequency shear waves. , the pressure detector 220 is used to detect the pressure of the probe 20 on its contact part, and the transducer 230 is used for acoustic (ultrasonic signal) electrical signal conversion. Wherein, the pressure detector 220 transmits the detected pressure value information to the pressure detection processor 116 in the tissue parameter detection module 110, and the pressure detection processor 116 transmits the pressure value information to the first control process device 111, so as to realize real-time monitoring of the pressure information between the probe 20 and the part in contact with it. Wherein, the imaging frequency of the probe is: 0.5-50MHz; the imaging frame frequency of the probe is: 0.1-100000Hz; the imaging depth of the probe is: 0.1-500mm; the imaging sampling frequency of the probe is: 1 -500MHz.

Wherein, the tissue imaging and parameter detection system integrates a tissue parameter detection mode and an imaging mode, wherein the tissue parameter detection mode is a tissue elasticity detection mode such as E-ultrasound, and the imaging mode includes A-ultrasound, M-ultrasound, B-ultrasound, CT, MRI, etc. Mode, and then integrate image guidance function and elastic detection function. After using the image guidance function to locate the best position, switch to the elastic detection mode to start the tissue parameter detection mode to achieve elastic detection. The application of the probe 20 realizes that the probe does not need to be replaced, and the position will not be shifted, so that the detection of tissue elasticity can be realized accurately, simply and efficiently.

The working principle of elasticity detection is as follows: the tissue parameter detection module 110 transmits a high-voltage excitation signal to drive the transducer 230 in the probe 20 to generate an ultrasonic signal, which propagates in the test body, and the ultrasonic echo is obtained due to the different reflections of the ultrasonic signal by the tissue in the test body. The difference of the wave signal is obvious and then the ultrasonic image is formed. The tissue parameter detection module 110 transmits a low-frequency excitation signal to drive the shear wave generator 210 in the probe 20, and the shear wave generator 210 generates a low-frequency shear wave, which propagates in the subject. The propagation velocity in the tissue is obviously different, and the tissue hardness can be accurately calculated by detecting the propagation velocity of the shear wave through the ultrasonic signal emitted from the probe 20 .

Below with the tissue parameter detection mode being the E-ultrasound, the specific application of the imaging mode being the B-ultrasound is an example, and is said to be the implementation process of the application example of the present invention:

When the control module 130 sends a control instruction to enter the imaging mode, the switch connects the imaging module 120 to the probe, the second control processor 121 sends a driving pulse to the second signal transmitter 124, and the The second signal transmitter 124 transmits the drive pulse to the probe 20 to drive the transducer 230 in the composite probe 20, and the transducer 230 converts the electrical signal into a B-type ultrasonic signal, and the B-type ultrasonic signal signal to detect the position of the object to be measured. The B-type ultrasonic signal carrying detection data is reflected by the measured body and received by the probe 20. The B-type ultrasonic signal is converted from the ultrasonic signal to an electrical signal by the transducer 230, and the probe 20 converts the electrical signal into an electrical signal. The signal is transmitted to the imaging module 120, and the second signal amplifier 122 in the imaging module 120 amplifies the electrical signal and then transmits it to the second analog-to-digital converter 123 for analog-to-digital conversion, and sends the digital signal to the The second control processor 121. The second control processor 121 performs operations such as data conversion, processing, and filtering on the digital signal to obtain a B-mode ultrasonic image.

When the control module 130 sends a control command to enter the E-ultrasound detection mode, the switch connects the tissue parameter detection module to the probe, and the first control processor 111 of the tissue parameter detection module sends a low-frequency excitation signal to the Shear wave driver 112, the low frequency excitation signal drives the shear wave generator 210 in the probe 20 to generate low frequency shear wave, the first control processor 111 of the tissue parameter detection module 110 sends a high voltage excitation signal to the Behind the compound probe 20, the high-voltage excitation signal drives the transducer 230 in the compound probe 20 to generate an ultrasonic signal. The ultrasonic signal detects the transmission speed of the low-frequency shear wave, the ultrasonic signal is reflected by the object under test, and the reflected signal is an echo, and the echo signal passes through the transducer 230 in the probe 20 Convert the ultrasonic signal into an electrical signal, the electrical signal is amplified by the first signal amplifier 113 of the tissue parameter detection module 110, and then transmitted to the first analog-to-digital converter 114 for analog-to-digital conversion, and the digital signal is transmitted to the tissue The first control processor 111 of the parameter detection module 110, the first control processor 111 performs digital processing, conversion and filtering on the digital signal to obtain an E-ultrasound image and hardness analysis.

The various technical features of the above-mentioned embodiments can be combined arbitrarily. To make the description concise, all possible combinations of the various technical features in the above-mentioned embodiments are not described. However, as long as there is no contradiction in the combination of these technical features, should be considered as within the scope of this specification.

The above-mentioned embodiments only express several implementation modes of the present invention, and the descriptions thereof are relatively specific and detailed, but should not be construed as limiting the patent scope of the invention. It should be noted that those skilled in the art can make several modifications and improvements without departing from the concept of the present invention, and these all belong to the protection scope of the present invention. Therefore, the protection scope of the patent for the present invention should be based on the appended claims.

Claims (9)

1. A tissue imaging and parameter detection system, comprising imaging and a parameter detection unit and a probe connected to it, is characterized in that, the imaging and parameter detection unit comprises: A tissue parameter detection module, configured to generate and process tissue parameter detection signals according to control instructions; an imaging module, configured to generate and process imaging signals according to control instructions; A control module, connected to the tissue parameter detection module, the imaging module, and the probe, for controlling the probe to enter tissue parameter detection mode or imaging mode, and sending control instructions to the tissue parameter detection module or imaging module . 2. The tissue imaging and parameter detection system according to claim 1, wherein the control module includes a switching control submodule, and the switching control submodule is used to control the probe between the tissue parameter detection mode and the tissue parameter detection mode. Switch between the imaging hypermodes. 3. The tissue imaging and parameter detection system according to claim 2, wherein the switching control submodule comprises a transfer switch, and the transfer switch is used to connect the parameter detection module or the imaging module with the Probe connection. 4. The tissue imaging and parameter detection system according to claim 1, wherein the tissue parameter detection module comprises a first control processor and a shear wave driver, and the first control processor communicates with the control the module and the shear wave driver are connected; The first control processor is configured to generate a first excitation signal according to a control instruction, and transmit the first excitation signal to a shear wave driver; The shear wave driver is used to receive the first excitation signal, amplify the excitation signal, transmit the amplified first excitation signal to the probe, and excite the probe to generate low-frequency shear wave. 5. The tissue imaging and parameter detection system according to claim 4, wherein the tissue parameter detection module further comprises a first signal transmitter connected to the first control processor , the first control processor transmits a second excitation signal and transmits it to the first signal transmitter, and the first signal transmitter transmits the second excitation signal to the probe to drive the probe to generate an ultrasonic signal . 6. The tissue imaging and parameter detection system according to claim 4, wherein the tissue parameter detection module further comprises a first analog-to-digital converter and a first signal amplifier, and the first control processor communicates with the The first analog-to-digital converter and the first signal amplifier are connected in sequence, and are used to amplify the echo signal detected by the probe through the first signal amplifier, and then convert the analog signal through the first analog-to-digital converter It is a digital signal and then transmitted to the first control processor. 7. The tissue imaging and parameter detection system according to claim 1, wherein the probe comprises a shear wave generator, a pressure detector and a transducer array, and the shear wave generator is used to generate low-frequency shear In cutting waves, the pressure detector is a pressure sensor or a displacement sensor, which is used to detect the pressure of the probe on its contact part, and the transducer array is used for acoustic-electric signal conversion. 8. The tissue imaging and parameter detection system according to claim 4, wherein, The frequency range of the low-frequency shear wave is: 1-1000Hz; The amplitude range of the low frequency shear wave is: 0.1-50mm. 9. The tissue imaging and parameter detection system according to claim 1, wherein The imaging frequency range of the probe is: 0.5-50MHz; The imaging frame frequency range of the probe is: 0.1-100000Hz; The imaging of the probe has a depth range of 0.1-500mm; The imaging sampling frequency range of the probe is: 1-500MHz.