CN110279909B - Blood perfusion device and blood purifying equipment - Google Patents

Abstract

The invention provides a blood perfusion device and blood purification equipment, which relates to the technical field of blood purification, and the blood perfusion device comprises: the first end cover, the second end cover and the cylinder body connected between the first end cover and the second end cover; the first end cover is provided with a liquid inlet and a diffusion cavity, the cylinder body is provided with a containing cavity for containing the adsorbent, the liquid inlet, the diffusion cavity and the containing cavity are sequentially communicated, and the liquid outlet of the second end cover is communicated with the containing cavity; the blood can flow into the diffusion cavity through the liquid inlet, flows into the adsorbent after fully flowing and diffusing in the diffusion cavity, and flows out of the liquid outlet. Blood enters the diffusion cavity from the liquid inlet, so that the blood flows and diffuses fully, and then flows to the adsorbent to enable the blood to be in full contact with the adsorbent, so that the adsorption efficiency is improved, and the problems that the adsorption efficiency is reduced and the treatment time is prolonged because the blood cannot be in full contact with the adsorbent in the prior art are solved. The blood purification device comprises the blood perfusion device.

Description

Blood perfusion device and blood purifying equipment

Technical Field

The invention relates to the technical field of blood purification, in particular to a blood perfusion device and blood purification equipment.

Background

With the development of society, the medical level is continuously improved, and the in-vitro purification of blood is becoming a feasible mature technology; along with the development and popularization of blood purification technology in China, a blood perfusion device becomes one of important instruments for blood purification. The blood perfusion device is mainly applied to adsorption of molecular toxins in acute and chronic drug poisoning and uremia, and adsorption of pathogenic factors in the liver disease and immune field at present. The main application modes at present are a single blood perfusion mode, a hemodialysis combined blood perfusion mode and a plasma separation adsorption mode.

The blood perfusion is to lead the blood of the patient out of the body for extracorporeal circulation, remove exogenous and endogenous poison, medicine and metabolic waste by utilizing the adsorption effect of the adsorbent in the extracorporeal circulation perfusion device, and then re-input the purified blood into the body of the patient, thereby achieving the purpose of blood purification.

In the prior art, blood is input into the blood perfusion device from the liquid inlet and directly enters into the adsorption cavity to be adsorbed and purified by contacting with the adsorbent, the blood directly enters into the adsorption cavity from the liquid inlet, the diameter of the liquid inlet is smaller, and under the pushing of blood pressure, the blood cannot be fully diffused and unfolded when initially entering into the adsorption cavity, so that the blood cannot be fully contacted with the adsorbent, the adsorbent cannot fully exert the adsorption effect, the adsorption efficiency is reduced, and the treatment time is prolonged.

Disclosure of Invention

The invention aims to provide a blood perfusion device and blood purification equipment, which are used for solving the problems that the adsorption efficiency is reduced and the treatment time is prolonged because blood cannot be fully contacted with an adsorbent in the prior art.

The present invention provides a blood perfusion apparatus, comprising: the first end cover, the second end cover and the cylinder body connected between the first end cover and the second end cover.

The first end cover is provided with a liquid inlet and a diffusion cavity, the barrel is provided with a containing cavity for containing the adsorbent, the liquid inlet, the diffusion cavity and the containing cavity are sequentially communicated, and the liquid outlet of the second end cover is communicated with the containing cavity.

The blood can flow into the diffusion cavity through the liquid inlet, flows into the adsorbent after fully flowing and diffusing in the diffusion cavity, and flows out of the liquid outlet.

Further, the diffusion cavity is a cavity surrounded by the arc-shaped inner cavity wall of the first end cover, the cross section area of the diffusion cavity gradually increases along the blood flowing direction, and the opening of the diffusion cavity is in butt joint with the first port of the cylinder body.

Further, the second end cover is a collection cavity surrounded by the arc-shaped inner cavity wall of the second end cover, the second end cover is provided with a collection cavity formed by the arc-shaped inner cavity wall of the second end cover, the collection cavity is communicated with the liquid outlet, the cross-sectional area of the collection cavity is gradually reduced along the flowing direction of blood, and the opening of the collection cavity is in butt joint with the second port of the barrel.

Further, the second end cover and the first end cover are both provided with internal thread structures, and the outer walls of the two ends of the cylinder are provided with external thread structures which are used for being in threaded connection with the internal thread structures.

Further, the blood perfusion device comprises a filter component arranged in the accommodating cavity; the filter assembly is positioned between the second end cap and the adsorbent and between the first end cap and the adsorbent.

Further, the filter assembly includes a screen, an annular frame, a central disk, and support spokes.

The central disk body sets up in the central point of annular frame puts, and multiunit supports spoke interval connection between central disk body and annular frame, and supports the spoke and outwards diverge from the center of annular frame.

The filter screen is connected to the annular outer frame.

Further, the central disk body is a concave disk body or a convex disk body.

Further, the blood perfusion device comprises a sealing ring; the sealing ring is sleeved on the outer ring side wall of the annular outer frame, and the sealing ring can be in butt joint with the inner side wall of the cylinder body.

Further, the blood perfusion device comprises a sealing cover for sealing the liquid inlet and the liquid outlet; the sealing cover is in threaded connection with the liquid inlet and the liquid outlet.

The invention provides blood purification equipment, which comprises the blood perfusion device.

Compared with the prior art, the blood perfusion device and the blood purification equipment provided by the invention have the technical advantages that:

The present invention provides a blood perfusion apparatus, comprising: a second end cap, a first end cap, and a barrel connected between the second end cap and the first end cap; the first end cover is provided with a liquid inlet and a diffusion cavity, the cylinder body is provided with a containing cavity for containing the adsorbent, the liquid inlet, the diffusion cavity and the containing cavity are sequentially communicated, and the liquid outlet of the second end cover is communicated with the containing cavity; the blood can flow into the diffusion cavity through the liquid inlet, flows into the adsorbent after fully flowing and diffusing in the diffusion cavity, and flows out of the liquid outlet. In the above-mentioned structure, inlet, diffusion chamber, hold chamber and liquid outlet intercommunication in proper order, be provided with the adsorbent in the holding chamber of barrel, blood enters into the diffusion chamber by the inlet, flows the diffusion in the diffusion chamber for the abundant diffusion expansion of the stranded blood that flows into from the inlet, later infiltration is in holding the adsorbent in the chamber, and the blood of abundant diffusion expansion can fully contact with the adsorbent, and the blood through the adsorption process flows out the blood perfusion device through the liquid outlet. In the structure, blood flows into the diffusion cavity from the liquid inlet of the first end cover with smaller diameter, the diffusion cavity is communicated with the accommodating cavity, the accommodating cavity is provided with the adsorbent, compared with the permeation of blood into the adsorbent, the resistance of the flowing diffusion of the blood in the diffusion cavity is smaller, so that the blood can be firstly diffused and unfolded in the diffusion cavity until the diffusion cavity is full of the blood, and then the blood permeates into the adsorbent under the action of blood pressure, in the process, the blood is fully diffused and unfolded, so that the blood can be fully contacted with the adsorbent, the adsorbent can be used for adsorbing harmful substances in the blood more efficiently and more rapidly, and the problems that the adsorption efficiency is reduced and the treatment time is prolonged because the blood cannot be fully contacted with the adsorbent in the prior art are solved.

The invention provides blood purification equipment, which comprises the blood perfusion device, and the advantages of the blood purification equipment comprise the advantages of the blood perfusion device, and are not repeated.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings that are needed in the description of the embodiments or the prior art will be briefly described, and it is obvious that the drawings in the description below are some embodiments of the present invention, and other drawings can be obtained according to the drawings without inventive effort for a person skilled in the art.

FIG. 1 is a schematic view of a blood perfusion apparatus according to an embodiment of the present invention;

Fig. 2 is a schematic diagram of an internal structure of a blood perfusion apparatus according to an embodiment of the present invention;

FIG. 3 is a schematic view showing a part of an internal structure of a blood perfusion apparatus according to an embodiment of the present invention;

FIG. 4 is a schematic diagram of an exploded structure of a blood perfusion apparatus according to an embodiment of the present invention;

Fig. 5 is a schematic structural view of a first end cap of a hemoperfusion apparatus according to an embodiment of the present invention;

FIG. 6 is a schematic diagram showing a first filter assembly and sealing ring matching structure of a blood perfusion apparatus according to an embodiment of the present invention;

FIG. 7 is a schematic diagram of an explosion structure of a filter assembly and a seal ring of a blood perfusion apparatus according to an embodiment of the present invention;

fig. 8 is a schematic structural view of a second filtering component of the blood perfusion apparatus according to an embodiment of the present invention.

Icon: 100-cylinder; 110-a receiving cavity; 200-a first end cap; 210-a liquid inlet; 220-a diffusion chamber; 300-a second end cap; 310-a liquid outlet; 320-collection chamber; 400-a filter assembly; 410-an annular outer frame; 420-a filter screen; 430-central tray; 440-support spokes; 500-sealing rings; 510-sealing the groove; 600-adsorbent; 700-capping.

Detailed Description

The following description of the embodiments of the present invention will be made apparent and fully in view of the accompanying drawings, in which some, but not all embodiments of the invention are shown. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.

In the description of the present invention, it should be noted that the directions or positional relationships indicated by the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc. are based on the directions or positional relationships shown in the drawings, are merely for convenience of describing the present invention and simplifying the description, and do not indicate or imply that the devices or elements referred to must have a specific orientation, be configured and operated in a specific orientation, and thus should not be construed as limiting the present invention. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.

The invention will now be described in further detail with reference to specific examples thereof in connection with the accompanying drawings.

The specific structure is shown in fig. 1-8.

The embodiment provides a blood perfusion apparatus, according to fig. 1 to 8, including: a first end cap 200, a second end cap 300, and a cylinder 100 connected between the first end cap 200 and the second end cap 300.

The first end cap 200 has a liquid inlet 210 and a diffusion chamber 220, the cartridge 100 has a receiving chamber 110 for receiving the adsorbent, the liquid inlet 210, the diffusion chamber 220, and the receiving chamber 110 are sequentially communicated, and a liquid outlet 310 of the second end cap 300 is communicated with the receiving chamber 110.

Blood can flow into the diffusion chamber 220 through the liquid inlet 210, and after sufficient flow diffusion in the diffusion chamber 220, flows to the adsorbent 600 and out of the liquid outlet 310.

In the above-described structure, specifically, the liquid inlet 210, the diffusion chamber 220, the accommodating chamber 110, and the liquid outlet 310 are sequentially communicated, the adsorbent 600 is disposed in the accommodating chamber 110 of the cartridge 100, and the blood enters the diffusion chamber 220 from the liquid inlet 210, flows and diffuses in the diffusion chamber 220, so that the stranded blood flowing in from the liquid inlet 210 is sufficiently diffused and spread, and then permeates into the adsorbent 600 of the accommodating chamber 110, the sufficiently diffused and spread blood can be sufficiently contacted with the adsorbent 600, and the blood passing through the adsorption process flows out of the blood perfusion apparatus through the liquid outlet 310. In the above structure, blood flows from the liquid inlet 210 with smaller diameter into the diffusion chamber 220, the diffusion chamber 220 is communicated with the accommodating chamber 110, the adsorbent 600 is arranged in the accommodating chamber 110, and compared with the permeation of blood into the adsorbent 600, the resistance of the flowing diffusion of the blood in the diffusion chamber 220 is smaller, so that the blood can be firstly diffused and spread in the diffusion chamber 220 until the diffusion chamber 220 is full, and then the blood permeates into the adsorbent 600 under the action of blood pressure, in the process, the blood is sufficiently diffused and spread, so that the blood can be fully contacted with the adsorbent 600, and the adsorbent 600 can adsorb harmful substances in the blood more efficiently and more rapidly, thereby shortening the treatment time.

Preferably, the blood perfusion device adopts a mode of liquid outlet from the upper end of liquid inlet at the lower end, so that the blood flows in the blood perfusion device for a longer time, the adsorption time is more sufficient, and the adsorption effect is better. Thus, the first end cap 200 of the blood perfusion device is connected with the first port of the cylinder 100, meanwhile, the liquid inlet 210 of the first end cap 200 is communicated with the diffusion cavity 220, so that blood can enter from the liquid inlet 210 of the first end cap 200, then flows and diffuses fully in the diffusion cavity 220 and gradually accumulates, under the action of blood pressure, the fully diffused blood in the diffusion cavity 220 is more and more until flowing into the accommodating cavity 110 of the cylinder 100 above the diffusion cavity 220 and contacting with the adsorbent 600, the adsorbent 600 adsorbs the blood, the blood moves upwards continuously under the action of the blood pressure, and finally the blood completing the adsorption process flows out from the liquid outlet 310 of the second end cap 300.

In an alternative solution of this embodiment, referring mainly to fig. 1-5, the diffusion cavity 220 is a cavity surrounded by an arc-shaped inner cavity wall of the first end cap 200, and the cross-sectional area of the diffusion cavity 220 gradually increases along the blood flow direction, and the opening of the diffusion cavity 220 is in butt joint with the first port of the cylinder 100.

Preferably, the diffusion cavity 220 is an inner cavity of the first end cap 200, an opening is formed on a side of the inner cavity away from the liquid inlet 210, the opening of the diffusion cavity 220 is used for being in butt joint with the first port of the cylinder 100, so that blood can smoothly flow into the accommodating cavity 110 of the cylinder 100, it should be noted that, in order to ensure that the diffusion cavity 220 can fully spread and diffuse the blood, the cross-sectional area of the diffusion cavity 220 needs to be larger than that of the liquid inlet 210, and the cross-sectional area of the diffusion cavity 220 gradually increases along the flowing direction of the blood, so that the blood is fully spread and spread in the diffusion cavity 220, the caliber of the opening of the diffusion cavity 220 is consistent with the caliber of the lower port of the cylinder 100, so that when the blood enters the accommodating cavity 110 from the diffusion cavity 220, the contact surface of the blood and the adsorbent 600 is larger, so that the adsorbent 600 fully contacts the blood, and the adsorption efficiency is improved. Blood can be injected into the diffusion cavity 220 with great pressure under the effect of blood pressure, the characteristic that the blood flows fast in the diffusion cavity 220 is utilized, the arc-shaped inner cavity wall is adopted, so that the blood forms vortex when flowing along the arc-shaped inner cavity wall, the blood can be quickly diffused in the diffusion cavity 220, meanwhile, by utilizing the vortex, the flowing speed of the blood in a certain horizontal direction is still kept after the blood enters the accommodating cavity 110, the blood can impact the adsorbent 600 to a certain extent, the adsorbent 600 can vibrate in the blood to a certain extent, and the adsorbent 600 and the blood can be fully mixed under the stirring effect of the vibration, so that the blood and the adsorbent 600 can be fully contacted, and the adsorption efficiency is improved. Alternatively, the diffusion chamber 220 may be a tapered inner chamber having a diameter gradually increasing in the blood flow direction.

In an alternative solution of this embodiment, referring mainly to fig. 1-4, the second end cap 300 has a collecting cavity 320 surrounded by an arc-shaped inner cavity wall of the second end cap 300, the collecting cavity 320 is communicated with the liquid outlet 310, and the cross-sectional area of the collecting cavity 320 is gradually reduced along the blood flowing direction, and the opening of the collecting cavity 320 is in butt joint with the second port of the barrel 100.

Preferably, the second end cap 300 has an arc-shaped inner cavity wall, the inner cavity wall is a collection cavity 320, the second end cap 300 has a liquid outlet 310, the liquid outlet 310 is arranged at the top of the arc-shaped inner cavity wall, the liquid outlet 310 is arranged at the opposite side of an opening of the collection cavity 320, the opening of the collection cavity 320 is connected with the second port of the cylinder 100, the opening of the collection cavity 320 is consistent with the caliber of the second port of the cylinder 100, the cross-sectional area of the collection cavity 320 is gradually reduced along the blood flowing direction until the position of the liquid outlet 310, and the caliber of the collection cavity 320 is overlapped with the caliber of the liquid outlet 310. After the blood passes through the cylinder 100 and is adsorbed and purified by the adsorbent 600 in the accommodating cavity 110, the blood flows out of the second port of the cylinder 100 and enters the collecting cavity 320 of the second end cover 300, and the blood enters the collecting cavity 320, is collected to the liquid outlet 310 at the top of the second end cover 300 under the drainage effect of the arc-shaped inner cavity wall, and flows out of the liquid outlet 310. In the above process, the collection chamber 320 of the curved inner chamber wall of the second end cap 300 has a drainage effect. Alternatively, the collection chamber 320 may be a tapered lumen having a diameter that tapers in the direction of blood flow.

It should be noted that, the inner cavity walls of the first end cover 200 and the second end cover 300 are arc-shaped inner cavity walls, after the pre-filled blood flows into the blood perfusion device, air bubbles are generated on the inner cavity walls of the first end cover 200 and the second end cover 300, in order to prevent the air bubbles from entering the blood vessel of the patient to cause embolism and other problems, the air bubbles need to be discharged out of the blood perfusion device before the blood is returned to the blood vessel of the patient, and in the air bubble discharging process, compared with the planar inner cavity walls, the arc-shaped inner cavity walls in the embodiment are more beneficial to the air bubbles on the wall to be upwards slid and discharged along the arc-shaped inner cavity walls. When the air bubbles are generated, the hemoperfusion apparatus is flicked or rocked, the air bubbles slide upwards along the arc-shaped inner cavity wall of the first end cover 200, slide through the inner cavity wall of the cylinder body 100 and enter the arc-shaped inner cavity wall of the second end cover 300, and the air bubbles hanging on the second end cover 300 slide upwards along the arc-shaped inner cavity wall of the second end cover 300 and are discharged from the liquid outlet 310 of the second end cover 300, so that the air bubbles are rapidly discharged. And the rapid discharge of bubbles makes the blood priming process faster and the efficiency higher.

In an alternative solution of this embodiment, referring mainly to fig. 1-5, the second end cap 300 and the first end cap 200 each have an internal thread structure, and the outer walls of the two ends of the cylinder 100 have external thread structures for threaded connection with the internal thread structures.

Preferably, a connection port is disposed at an opening position of the collecting cavity of the second end cover 300, a connection port is also disposed at an opening position of the diffusion cavity of the first end cover 200, both connection ports are provided with internal thread structures, the internal thread structures of the connection ports of the second end cover 300 and the first end cover 200 can be respectively in threaded connection with external thread structures of the outer wall of the cylinder 100, which are close to the second port and the first port, so as to realize that an opening of the collecting cavity 320 is in butt joint with the second port of the cylinder 100, and an opening of the diffusion cavity 220 is in butt joint with the first port of the cylinder 100. The second end cover 300, the first end cover 200 and the whole body are conveniently and quickly assembled and disassembled by adopting a threaded connection mode.

In an alternative aspect of this embodiment, referring primarily to fig. 2-4, 6 and 7, the hemodiafiltration device includes a filter assembly 400 disposed within the containment chamber 110; the filter assembly 400 is positioned between the second end cap 300 and the adsorbent 600, and between the first end cap 200 and the adsorbent 600.

The filter assembly 400 is disposed between the second end cap 300 and the adsorbent 600, and is used for filtering harmful substances in blood flowing to the adsorbent 600; or a filtering means is provided between the first end cap 200 and the adsorbent 600 for filtering harmful substances in blood to be flowed to the collection chamber 320 and impurities carried from the adsorbent 600; preferably, the filter assemblies 400 are disposed between the second end cap 300 and the adsorbent 600 and between the first end cap 200 and the adsorbent 600, so that the blood is filtered once before entering the adsorbent 600, and is filtered twice after flowing out of the adsorbent 600, thereby ensuring the purifying effect of the blood and realizing the double filtration of the blood. A filter assembly 400 is disposed between the first end cap 200 and the adsorbent 600, and blood enters the diffusion chamber 220 of the first end cap 200 from the liquid inlet 210 of the first end cap 200, and after the blood is sufficiently diffused in the diffusion chamber 220, the blood flows to the filter assembly 400 along with the continuous accumulated rising of the blood, and the harmful substances in the blood are filtered after the blood flows through the filter assembly 400 by the filtering action of the filter assembly 400. After the blood completes the adsorption process in the receiving chamber 110, it flows to the filter assembly 400 between the second end cap 300 and the adsorbent 600, and the filter assembly 400 secondarily filters harmful substances in the blood and filters impurities carried out of the adsorbent 600 by the blood. Through the process, double filtration of blood is completed, and the purifying effect of the blood is improved.

Specifically, as shown in fig. 8, the filter assembly 400 at least includes a filter screen 420, wherein the filter screen 420 is provided with filter holes, the arrangement density of the filter holes is 30-170 meshes, the filter screen 420 is disposed between the first end cover 200 and the adsorbent 600, and is used for filtering the blood flowing from the diffusion chamber 220 to the adsorbent once, so that harmful substances in the blood are filtered, and the blood is purified; a filter screen 420 is also provided between the second end cap 300 and the adsorbent 600 for secondarily filtering the blood flowing from the receiving chamber 110 to the collecting chamber 320 so that harmful substances in the blood and impurities carried out from the adsorbent 600 are filtered, thereby purifying the blood.

In an alternative embodiment, referring primarily to fig. 6 and 7, the filter assembly 400 preferably includes a screen 420, an annular outer frame 410, a central disk 430, and support spokes 440.

The central disk 430 is disposed at the center of the annular outer frame 410, a plurality of groups of support spokes 440 are connected between the central disk 430 and the annular outer frame 410 at intervals, and the support spokes 440 diverge outwardly from the center of the annular outer frame 410.

The filter screen 420 is connected to the annular outer frame 410.

The above-mentioned filtering assembly 400 includes an annular frame 410, supporting spokes 440, a central disk 430 and a filtering screen 420, wherein the annular frame 410 has an annular structure with a certain thickness, preferably, three supporting spokes 440 are uniformly spaced, the supporting spokes 440 are outwardly dispersed from the center of the annular frame 410 and are connected with the inner side wall of the annular frame 410, the central disk 430 is disposed at the center of the annular frame 410 and is connected with one end of the supporting spokes 440, and the filtering screen 420 is laid on one side of the annular frame 410 facing the adsorbent 600, so that the blood flows through the filtering screen 420 before entering the adsorbent 600 or before flowing out of the accommodating chamber 110, and is filtered; the support spokes 440 are used to connect and fix the central disk 430, and the central disk 430 is mainly used to block the blood flowing from the liquid inlet 210, prevent the blood from directly flowing through the filter assembly 400, and avoid insufficient blood diffusion. In the filter assembly 400 between the first end cap 200 and the adsorbent 600, the central disc 430 is disposed at the center of the circle, opposite to the liquid inlet 210, and after flowing into the liquid inlet 210 under the action of blood pressure, the blood has a certain initial velocity and can directly flow to the central disc 430 of the filter assembly 400, while the central disc 430 can block the blood from passing through, and the blood flows back to the diffusion chamber 220 for full diffusion under the blocking of the central disc 430, and after being fully diffused, flows through the filter screen 420 laid on one side of the annular outer frame 410 facing the adsorbent 600, so that the blood is filtered. Preferably, a raised step structure is provided in the interior of the cylinder 100, the annular outer frame 410 of the filter assembly 400 adjacent to the first end cap 200 is erected on the step structure adjacent to the first end cap 200, and when the first end cap 200 is connected to the cylinder 100 by using a screw structure, the connection port of the first end cap 200 abuts against one end of the annular outer frame 410 adjacent to the first end cap 200 and compresses the annular outer frame 410, preventing the annular outer frame from falling out of the cylinder 100; the annular outer frame 410 of the filter assembly 400 near the second end cap 300 is erected on the step structure near the second end cap 300, and when the second end cap 300 is connected to the cylinder 100 by using the screw structure, the connection port of the second end cap 300 abuts against one end of the annular outer frame 410 near the second end cap 300 and compresses the annular outer frame 410, preventing the second end cap 300 from falling out of the cylinder 100.

Preferably, the filter assembly 400 consisting of the annular outer frame 410, the support spokes 440, the center plate, and the filter screen 420 may be integrally formed using an injection molding process.

In an alternative solution of this embodiment, referring mainly to fig. 6 and 7, the central disc 430 is a concave disc or a convex disc.

Preferably, the central disk 430 is a convex disk having protrusions or a concave disk having depressions; when blood is gushed into the liquid inlet 210 under the action of blood pressure and directly falls on the convex or concave structure of the central disk body 430, the convex or concave structure can play a role in buffering and guiding the blood, so that the flowing direction of the blood is changed, and the arc inner cavity surface of the diffusion cavity 220 is matched, so that the blood forms vortex in the diffusion cavity 220, the blood is rapidly and fully diffused, and the purposes of enabling the blood to be in full contact with the adsorbent 600 more rapidly and improving the adsorption and purification efficiency are achieved.

In an alternative solution of the present embodiment, referring mainly to fig. 3, 6 and 7, the blood perfusion apparatus includes a sealing ring 500; the sealing ring 500 is sleeved on the outer ring side wall of the annular outer frame 410, and the sealing ring 500 can be in abutting sealing with the inner side wall of the cylinder 100.

Specifically, the sealing ring 500 is sleeved on the outer sidewall of the annular outer frame 410, when the annular outer frame 410 is erected on the step structure in the cylinder 100, the sealing ring 500 is in contact with the inner sidewall of the cylinder 100 to seal, so that the problem that the blood flows into the diffusion chamber 220 and then directly flows into the adsorbent 600 from the gap between the cylinder 100 and the annular outer frame 410 without passing through the filter screen 420, and the filtering effect is not ideal is avoided.

Preferably, the sealing ring 500 is also of an annular structure, and the inner annular side wall of the sealing ring 500 is provided with an annular sealing groove 510, when the sealing ring 500 is sleeved on the annular outer frame 410, the annular outer frame 410 can be embedded in the sealing groove 510 and is in butt joint with the groove wall of the sealing groove 510, after the annular outer frame 410 sleeved with the sealing ring 500 is erected on the step structure on the inner wall of the cylinder 100, the outer annular side wall of the sealing ring 500 is in butt joint with the inner side wall of the cylinder 100, after the second end cover 300 or the first end cover 200 is connected with the cylinder 100 through the threaded structure, the connecting port of the second end cover 300 or the first end cover 200 is in butt joint with one end face of the sealing ring 500 on the annular outer frame 410, so that the second end cover 300 or the first end cover 200 can be in butt joint with the sealing ring 500 when the second end cover 300 or the first end cover 200 is pressed against the filter assembly 400, and a seal is formed between the second end cover 300 or the first end cover 200 and the cylinder 100, so that blood leakage is prevented.

In an alternative aspect of the present embodiment, referring mainly to fig. 1-4, the blood perfusion apparatus includes a cover 700 for sealing the liquid inlet 210 and the liquid outlet 310; the cover 700 is screwed to the liquid inlet 210 and the liquid outlet 310.

In the above structure, the cover 700 is screwed to the liquid inlet 210 and the liquid outlet 310, and when the blood perfusion apparatus is not in use, the liquid inlet 210 and the liquid outlet 310 are tightly sealed by the cover 700, so as to prevent bacterial contamination. Preferably, the outer side walls of the second end cover 300 and the first end cover 200 are provided with limiting protrusions, the opening of the sealing cover 700 is provided with an outward flange, the bottom surface of the outward flange is provided with a limiting groove, and after the sealing cover 700 is tightly screwed with the liquid inlet 210 and the liquid outlet 310, the limiting protrusions are just embedded into the limiting groove and lock the sealing cover 700, so that the sealing cover 700 is prevented from being loosened due to false touch or vibration.

The present embodiment also provides a blood purification apparatus including the blood perfusion device in the above embodiment.

The blood purifying device comprises a blood perfusion device, wherein the blood perfusion device comprises a cylinder body 100, a second end cover 300 and a first end cover 200 which are respectively connected with the cylinder body 100, a diffusion cavity 220 surrounded by an arc cavity wall is arranged in the first end cover 200, and a liquid inlet 210 is arranged at the opposite side of an opening of the diffusion cavity of the first end cover 200; the second end cap 300 has a collection chamber 320 surrounded by an arc-shaped chamber wall, and a liquid outlet 310 positioned on the opposite side of the opening of the second end cap 300; the second end cap 300 and the first end cap 200 are both communicated with the accommodating cavity 110 of the cylinder 100, the adsorbent 600 is arranged in the accommodating cavity 110, and the connection port of the second end cap 300 and the connection port of the first end cap 200 are respectively in threaded connection with the second port and the first port of the cylinder 100. Preferably, a filter assembly 400 is disposed between the second end cap 300 and the adsorbent 600, and a filter assembly 400 is also disposed between the first end cap 200 and the adsorbent 600, wherein the filter assembly 400 includes a filter screen 420, a central disk 430, an annular outer frame 410, and support spokes 440 connected to an inner annular sidewall of the annular outer frame 410 and disposed toward a center of a circle along a radial direction; the central disk 430 is disposed at the center of the annular frame 410 and connected to the support spokes 440, and the filter screen 420 is laid at one end of the annular frame 410. The annular outer frame 410 is further sleeved with a sealing ring 500, the sealing ring 500 is of an annular structure, and the side wall of the inner ring is further provided with an annular sealing groove 510 for embedding the annular outer frame 410.

Blood flows into the diffusion cavity 220 of the first end cover 200 from the liquid inlet 210 of the first end cover 200, and is flushed to the convex or concave central disk body 430, under the flow guiding effect of the central disk body 430, the arc-shaped diffusion cavity 220 is matched to enable blood pressure to form vortex in the diffusion cavity 220 and to be diffused rapidly, the fully diffused blood flows into the filter assembly 400 to be filtered, then enters the accommodating cavity 110, is adsorbed and purified under the effect of the adsorbent 600, and the purified blood is filtered secondarily from the filter assembly 400 close to the second end cover 300 and flows out from the liquid outlet 310 of the second end cover 300 through the collecting cavity 320.

Finally, it should be noted that: the above embodiments are only for illustrating the technical solution of the present invention, and not for limiting the same; although the invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical scheme described in the foregoing embodiments can be modified or some or all of the technical features thereof can be replaced by equivalents; such modifications and substitutions do not depart from the spirit of the invention.

Claims (7)

1. A blood perfusion apparatus, comprising: a first end cap (200), a second end cap (300), a cartridge (100) connected between the first end cap (200) and the second end cap (300), and a filter assembly (400) disposed within the receiving cavity (110);

The first end cover (200) is provided with a liquid inlet (210) and a diffusion cavity (220), the barrel (100) is provided with a containing cavity (110) for containing the adsorbent (600), the liquid inlet (210), the diffusion cavity (220) and the containing cavity (110) are communicated in sequence, and a liquid outlet (310) of the second end cover (300) is communicated with the containing cavity (110);

Blood can flow into the diffusion cavity (220) through the liquid inlet (210), and after being fully flowed and diffused in the diffusion cavity (220), flows to the adsorbent (600) and flows out from the liquid outlet (310);

The filter assembly (400) is located between the first end cap (200) and the adsorbent (600);

The diffusion cavity (220) is a cavity surrounded by the arc-shaped inner cavity wall of the first end cover (200), the cross-sectional area of the diffusion cavity (220) gradually increases along the blood flow direction, and an opening of the diffusion cavity (220) is in butt joint with the first port of the cylinder body (100);

The filter assembly (400) includes a screen (420), an annular outer frame (410), a central disk (430), and support spokes (440);

The central disc body (430) is arranged at the central position of the annular outer frame (410), a plurality of groups of support spokes (440) are connected between the central disc body (430) and the annular outer frame (410) at intervals, and the support spokes (440) are outwards dispersed from the center of the annular outer frame (410);

the filter screen (420) is connected to the annular outer frame (410);

The central disc body (430) is a concave disc body or a convex disc body;

Under the diversion effect of the central disk body (430), the arc-shaped diffusion cavity (220) is matched, so that blood forms vortex in the diffusion cavity (220) and rapidly diffuses.

2. The blood perfusion apparatus of claim 1, wherein the second end cap (300) has a collection chamber (320) surrounded by an arcuate inner chamber wall of the second end cap (300), the collection chamber (320) is in communication with the liquid outlet (310), and a cross-sectional area of the collection chamber (320) is tapered in a blood flow direction, an opening of the collection chamber (320) interfacing with the second port of the barrel (100).

3. The blood perfusion apparatus according to claim 1, wherein the second end cap (300) and the first end cap (200) each have an internal thread structure, and the outer walls of both ends of the cylinder (100) have external thread structures for screw-coupling with the internal thread structures.

4. A hemodiafiltration device according to any of claims 1-3, wherein the filtration assembly (400) is further located between the second end cap (300) and the adsorbent (600).

5. The blood perfusion apparatus according to claim 4, characterized by comprising a sealing ring (500); the sealing ring (500) is sleeved on the outer ring side wall of the annular outer frame (410), and the sealing ring (500) can be in butt seal with the inner side wall of the cylinder body (100).

6. The hemodiayer according to claim 1, characterized by comprising a cover (700) for sealing the liquid inlet (210) and the liquid outlet (310); the sealing cover (700) is in threaded connection with the liquid inlet (210) and the liquid outlet (310).

7.A blood purification apparatus comprising a hemodiafiltration device according to any one of claims 1-6.