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CN110275030B - Automatic analyzer for vaginal secretion - Google Patents

Automatic analyzer for vaginal secretion Download PDF

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Publication number
CN110275030B
CN110275030B CN201810205695.5A CN201810205695A CN110275030B CN 110275030 B CN110275030 B CN 110275030B CN 201810205695 A CN201810205695 A CN 201810205695A CN 110275030 B CN110275030 B CN 110275030B
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optical coupler
reaction
liquid
area
detection
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CN110275030A (en
Inventor
凌燕
贾汝福
王加义
万松平
杨路
钱进
周波
桂春爽
焦国宾
李静
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BEIJING ZHONGSHENG JINYU DIAGNOSIS TECHNOLOGY CO LTD
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BEIJING ZHONGSHENG JINYU DIAGNOSIS TECHNOLOGY CO LTD
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00346Heating or cooling arrangements

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  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

The invention relates to the technical field of medical equipment, in particular to an automatic analyzer for vaginal secretion. The invention provides an automatic analyzer for vaginal secretion, which comprises a control device, a liquid feeding device, a constant temperature heating device, a sample feeding mechanism, a conveying mechanism and a detection device, wherein the sample feeding mechanism, the conveying mechanism and the detection device are sequentially connected with the control device, and the control device is respectively connected with the liquid feeding device, the constant temperature heating device, the sample feeding mechanism, the conveying mechanism and the detection device. Automatic sample feeding, conveying, liquid feeding and detecting operations are realized through the control device, the automation degree is high, and the coordination is good; in the process of detecting the vaginal secretion, automatic sample feeding and sample adding can effectively avoid the uncertain factors caused by manual sample feeding and improve the detection precision; in addition, the analysis appearance that this application provided still is equipped with constant temperature heating device, can keep the required temperature of effectual biochemical reaction in real time, and simple structure, reasonable in design, and is easy and simple to handle, does benefit to the promotion of practicing thrift manpower resources and check-out time and detection efficiency.

Description

Automatic analyzer for vaginal secretion
Technical Field
The invention relates to the technical field of medical equipment, in particular to an automatic analyzer for vaginal secretion.
Background
Currently, vaginal infections have been the focus of attention of clinicians as a common and frequently occurring disease in obstetrics and gynecology. Vaginal infections consist of a single infection and a mixture of infections, with common single infections including: aerobic Vaginitis (AV), Bacterial Vaginosis (BV), Cytolytic Vaginosis (CV), Desquamating Vaginitis (DV), Trichomonas Vaginitis (TV), vulvovaginal candidiasis (VVC) and the like, wherein the mixed infection consists of 2 or more than 2 single infections. Since Aerobic Vaginitis (AV) and Bacterial Vaginosis (BV) are common vaginal infection symptoms, the combined detection of the aerobic vaginitis and the bacterial vaginosis is a hot spot and a focus of research of clinical attention at present.
Since the pathogenic microorganisms of various vaginal infections differ in their sensitivity to antibiotics, clinical medication must be guided by definitive diagnosis. In order to solve the problem, an analyzer (Jing Ji Zhui Standard 20172400785) matched with a corresponding five-item combined determination kit for the aerobic vaginitis/bacterial vaginosis can be used for diagnosing vaginal infection diseases, and biochemical detection more intuitively provides a targeted treatment reference for clinicians. However, some steps in the detection process need to be completed manually, which not only reduces the detection speed and consumes human resources, but also affects the variation degree of the detection result. For example, the result of the detection may be biased by habitual overdosing by an inspector or by failure to timely interpret the reaction after completion of the reaction.
Disclosure of Invention
Technical problem to be solved
The purpose of the invention is: the automatic analyzer for vaginal secretions is simple in structure, reasonable in design, high in automation degree, capable of effectively saving human resources and improving detection precision and detection efficiency, and solves the problems that partial steps of an existing analyzer need manual operation, detection speed is low, detection precision is low, and human resources are consumed.
(II) technical scheme
In order to solve the technical problems, the invention provides an automatic analyzer for vaginal secretion, which comprises a control device, a liquid feeding device, a constant temperature heating device, a sample feeding mechanism, a conveying mechanism and a detection device, wherein the sample feeding mechanism, the conveying mechanism and the detection device are sequentially connected; the liquid feeding device is used for adding a reaction liquid and a color development liquid into an original sample; the constant-temperature heating device is used for ensuring the temperature of the biochemical reaction of the original sample with the reaction liquid and the color development liquid; and the detection device carries out detection analysis according to the result of the biochemical reaction.
According to the above technical scheme, preferably, the sample feeding device further comprises a reaction device plate for placing the original sample and a bracket for fixedly mounting the control device, the liquid feeding device, the constant temperature heating device, the sample feeding mechanism, the conveying mechanism and the detection device, wherein the bracket comprises a conveying channel, the conveying mechanism comprises a driving module, and the driving module drives the reaction device plate to move along the moving direction of the conveying channel.
According to the preferable technical scheme, the driving module comprises a module main body, and a linear guide rail, a synchronous belt, a driven wheel, a stepping motor, a moving frame, a linear lifting motor and a lifting push rod which are arranged on the module main body; the linear lifting motor is connected with a lifting push rod, the linear lifting motor and the lifting push rod are both arranged on the moving frame, and the synchronous belt and the driven wheel are respectively connected with the stepping motor; the moving frame is slidably arranged on the linear guide rail and comprises an embedding groove for embedding the synchronous belt; the linear lifting motor drives the lifting push rod to ascend until the lifting push rod pushes against the reaction device plate or descends, and the stepping motor drives the moving frame to drive the reaction device plate to move along the direction of the conveying channel.
According to the above technical scheme, the support further comprises two guide strips which are arranged along the moving direction of the transmission channel, the two guide strips are coplanar and are respectively arranged above the left side and the right side of the transmission channel, and the gap between each guide strip and the transmission channel is not smaller than the edge thickness of the reaction device plate.
According to the technical scheme, the support further comprises a left side plate, a right side plate, an upper beam and at least one cross beam used for connecting the left side plate and the right side plate, the two guide strips are respectively arranged on the left side plate and the right side plate, the upper beam is arranged above the transmission channel and the guide strips, and the detection device and the liquid conveying device are both arranged on the upper beam.
According to the optimization of the technical scheme, the transmission channel is divided into an area A, an area B and an area C from the direction of the sample feeding mechanism pointing to the detection device; the area A and the area B are respectively provided with the liquid feeding device and the conveying mechanism which independently operate, the starting end of the area A is provided with a first liquid feeding optocoupler, a first timing optocoupler and a first end point optocoupler, and the end point end of the area A is provided with a first homing optocoupler and a second homing optocoupler; a second terminal optical coupler, a second liquid feeding optical coupler and a second timing optical coupler are arranged at the starting end of the area B, and a third homing optical coupler and a detection optical coupler are arranged in the area C;
the first end point optical coupler and the first homing optical coupler are respectively connected with a driving module of the A-zone transmission mechanism; the second homing optocoupler, the second end point optocoupler and the third homing optocoupler are respectively connected with a driving module of the B area transmission mechanism; and the first liquid adding optical coupler, the first timing optical coupler, the first end point optical coupler, the first homing optical coupler, the second end point optical coupler, the second liquid adding optical coupler, the second timing optical coupler, the second homing optical coupler, the third homing optical coupler and the detection optical coupler are respectively connected with the control device.
According to the optimization of the technical scheme, the liquid feeding device comprises a peristaltic pump, a liquid feeding optical coupler, a liquid feeding pipeline and a liquid storage container, wherein the liquid feeding optical coupler is connected with the peristaltic pump, one end of the liquid feeding pipeline is immersed into a stock solution of the liquid storage container, and the other end of the liquid feeding pipeline faces the reaction device plate; the liquid storage container is provided with a temperature control module connected with the control device, and the temperature control module is used for setting corresponding storage temperature according to the storage conditions of different reaction liquids.
According to the preferable technical scheme, the constant temperature heating device comprises a PTC low-voltage heater and a low-voltage temperature control circuit, and the low-voltage temperature control circuit is respectively connected with the PTC low-voltage heater and the control device; the PTC low-voltage heater is tightly attached to the bottom of the transmission channel, the reaction device plate is tightly attached to the upper surface of the transmission channel, and the transmission channel is made of a heat-conducting material.
According to the above technical scheme, preferably, the detection device comprises a CCD light sensation detection device, the CCD light sensation detection device comprises a housing, an illumination light source, a light source control circuit, a CCD sensor and a signal processing circuit, the illumination light source, the light source control circuit, the CCD sensor and the signal processing circuit are arranged in the housing, the light source control circuit is connected with the illumination light source, and the light source control circuit and the signal processing circuit are respectively connected with the control device.
According to the preferable technical scheme, the sample feeding mechanism comprises a first pushing module and a second pushing module which is coplanar with the first pushing module and is perpendicular to the first pushing module, the starting end of the first pushing module is arranged at the inlet end of the analyzer, the terminal end of the first pushing module is the starting end of the second pushing module, and the terminal end of the second pushing module is arranged close to the transmission channel; the first pushing module and the second pushing module respectively comprise a guide rail, a linear lifting motor, a sliding block and an optical coupler, and when the optical coupler detects the original sample, the linear lifting motor drives the sliding block to drive the original sample to move along the trend of the guide rail.
(III) advantageous effects
The technical scheme of the invention has the following advantages:
the invention provides an automatic analyzer for vaginal secretion, which comprises a control device, a liquid feeding device, a constant temperature heating device, a sample feeding mechanism, a conveying mechanism and a detection device, wherein the sample feeding mechanism, the conveying mechanism and the detection device are sequentially connected; the liquid conveying device is used for adding reaction liquid and color development liquid into the original sample; the constant-temperature heating device is used for ensuring the temperature of the biochemical reaction of the original sample and the reaction liquid and the color development liquid; the detection device carries out detection analysis according to the result of the biochemical reaction. By adopting the automatic analyzer for vaginal secretion provided by the application, automatic sample introduction, transmission, liquid feeding and detection operations are realized through the control device, the automation degree is high, and the coordination is good; in the process of detecting the vaginal secretion, automatic sample feeding and sample adding can effectively avoid the uncertain factors caused by manual sample feeding and improve the detection precision; in addition, the analysis appearance that this application provided still is equipped with constant temperature heating device, can keep the required temperature of effectual biochemical reaction in real time, does benefit to further to improve and detects the precision, and simple structure, reasonable in design, it is easy and simple to handle, do benefit to the promotion of practicing thrift manpower resources and check-out time and detection efficiency, the practicality is strong, does benefit to and carries out standardized production and popularization.
Drawings
FIG. 1 is a schematic view showing the structure of an analyzer according to an embodiment of the automatic vaginal secretion analyzer of the present invention;
FIG. 2 is a schematic diagram showing the structure of a reaction device plate according to an embodiment of the automatic analyzer for vaginal discharge of the present invention;
FIG. 3 is a schematic diagram of the structure of a transport mechanism of an embodiment of an automatic vaginal secretion analyzer of the present invention;
FIG. 4 is a schematic structural view of a holder of an embodiment of the automatic vaginal secretion analyzer of the present invention;
FIG. 5 is a schematic structural diagram of a plurality of reaction device plates and transmission channels of an embodiment of an automatic analyzer for vaginal discharge according to the present invention.
In the figure: 1: a sample introduction mechanism; 2: a transport mechanism; 3: a support; 4: a liquid feeding device; 5: a constant temperature heating device; 6: a detection device; 7: a reaction apparatus plate; 8: a linear guide rail; 9: a stepping motor; 10: a synchronous belt; 11: a driven wheel; 12: a movable frame; 13: a linear lifting motor; 14: a lifting push rod; 15: a transmission channel; 16: a guide strip; 17: an upper beam; 18: a cross beam; 19: and a support pillar.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are some, but not all, embodiments of the present invention. All other embodiments, which can be obtained by a person skilled in the art without any inventive step based on the embodiments of the present invention, are within the scope of the present invention.
As shown in fig. 1 to 5, an embodiment of the present invention provides an automatic analyzer for vaginal secretion, which includes a control device, a sample injection mechanism 1, a delivery mechanism 2, a support 3, a liquid delivery device 4, a constant temperature heating device 5, and a detection device 6, which are connected in sequence; the liquid feeding device 4 is used for adding a color development liquid and a reaction liquid into the original sample; the constant temperature heating device 5 is used for ensuring the temperature of the biochemical reaction of the original sample, the color development liquid and the reaction liquid; the detection device 6 performs detection analysis according to the result of the biochemical reaction.
Specifically, the automatic analyzer for vaginal secretion provided by the application comprises a sample introduction mechanism 1, a conveying mechanism 2, a support 3, a liquid feeding device 4, a constant temperature heating device 5, a detection device 6 and a control device. Wherein, the sample injection mechanism 1 is disposed at an inlet end of the analyzer, and is used for feeding an original sample (i.e. a diluted sample containing vaginal secretion) to a starting position in the analyzer, in this embodiment, the starting position of the analyzer refers to a starting end of the transmission channel 15 on the bracket; the starting end of the conveying mechanism 2 is adjacent to the conveying channel 15 on the bracket, and the terminal end of the conveying mechanism 2 is close to the detection device 6 and is used for conveying the original sample to a specified position; the liquid conveying device 4 is used for processing the original sample, adding reaction liquid and color development liquid, carrying out biochemical reaction on a substrate in the reaction liquid and an enzyme to be detected in the original sample, and carrying out color development reaction on the color development liquid and a reaction product so as to be further identified by the detection device 6; the constant temperature heating device 5 is arranged at the bottom of the transmission channel 15 on the bracket and is used for providing reaction temperature for biochemical reaction so as to keep the temperature required by effective biochemical reaction in real time and be beneficial to further improving the detection precision; the detection device 6 reads the color change in the biochemical reaction and judges the detection result; the control device is used for controlling the operation of the analyzer, outputting an instruction according to a set program, processing a feedback signal and storing and displaying a reaction result.
Wherein, the sample is located reaction unit board 7 all the time in the testing process, and reaction unit board 7 is equipped with the recess, can hold the sample of equal gross volume and show liquid, reaction liquid.
By adopting the automatic analyzer for vaginal secretion provided by the application, automatic sample introduction, transmission, liquid feeding and detection operations are realized through the control device, the automation degree is high, and the coordination is good; in the process of detecting the vaginal secretion, automatic sample feeding and sample adding can effectively avoid the uncertain factors caused by manual sample feeding and improve the detection precision; in addition, the analysis appearance that this application provided still is equipped with constant temperature heating device, can keep the required temperature of effectual biochemical reaction in real time, does benefit to further to improve and detects the precision, and simple structure, reasonable in design, it is easy and simple to handle, do benefit to the promotion of practicing thrift manpower resources and check-out time and detection efficiency, the practicality is strong, does benefit to and carries out standardized production and popularization.
According to the optimization of the technical scheme, the device further comprises a reaction device plate 7 for placing an original sample, and a bracket 3 for fixedly mounting the control device, the liquid feeding device 4, the constant temperature heating device 5, the sample feeding mechanism 1, the conveying mechanism 2 and the detection device 6, wherein the bracket 3 comprises a conveying channel 15, the conveying mechanism 2 comprises a driving module, and the driving module drives the reaction device plate 7 to move along the moving direction of the conveying channel 15.
Further, the analyzer provided by the application further comprises a support 3, wherein the control device, the sample introduction mechanism 1, the conveying mechanism 2, the liquid conveying device 4, the constant temperature heating device 5, the detection device 6 and other components are all fixedly arranged on the support 3; the rack 3 comprises a transport channel 15 to provide a transfer guide for the raw sample; the device also comprises a reaction device plate 7, wherein the reaction device plate 7 is used for bearing the original sample, the developing solution and the reaction solution. When the sample feeding device is used, after an original sample enters the analyzer through the sample feeding mechanism 1, the driving module of the conveying mechanism 2 drives the reaction device plate 7 to move along the moving direction of the transmission channel 15, wherein the sample feeding operation and the biochemical reaction are completed in the transmission channel 15, and after the end point end of the transmission channel 15 is reached immediately, the detection device 6 is used for detecting and analyzing the result after the biochemical reaction.
According to the preferable technical scheme, the driving module comprises a module main body, a linear guide rail 8, a stepping motor 9, a synchronous belt 10, a driven wheel 11, a moving frame 12, a linear lifting motor 13 and a lifting push rod 14, wherein the linear guide rail 8, the stepping motor 9, the synchronous belt 10, the driven wheel, the moving frame 12, the linear lifting motor 13 and the lifting push rod 14 are arranged on the module main body; the linear lifting motor 13 is connected with the lifting push rod 14, the linear lifting motor 13 and the lifting push rod 14 are both arranged on the moving frame 12, and the synchronous belt 10 is connected with the stepping motor 9 and the driven wheel 11; the moving frame 12 is slidably arranged on the linear guide rail 8, and the moving frame 12 comprises a caulking groove for embedding the synchronous belt 10; the linear lifting motor 13 drives the lifting push rod 14 to ascend until the lifting push rod is pushed against the reaction device plate 7, and the stepping motor 9 drives the moving frame 12 to drive the reaction device plate 7 to move along the trend of the conveying channel 15.
Specifically, the driving module comprises a module body, a linear guide rail 8 arranged on the module body, a stepping motor 9, a synchronous belt 10, a driven wheel 11, a moving frame 12, a linear lifting motor 13 and a lifting push rod 14; wherein, linear lifting motor 13 and lift push rod 14 are installed on moving frame 12, moving frame 12 is installed on linear guide 8, can move along the length direction of linear guide 8, and moving frame 12 and hold-in range 10 gomphosis. The driven wheel 11 and the stepping motor 9 are respectively arranged at two ends (A area or B, C area) of a transmission unit of the linear guide rail 8, and the synchronous belt 10 is connected with the driven wheel 11. Therefore, the horizontal movement of the sample is realized by the stepping motor 9, the synchronous belt 10, the driven wheel 11, the moving frame 12 and the lifting push rod 14, and the lifting movement of the lifting push rod 14 is realized by driving the lifting push rod 14 by the linear lifting motor 13.
According to the preferred of the above technical scheme, the support further comprises two guide strips 16 which are arranged along the trend of the conveying channel 15, the two guide strips 16 are coplanar and are respectively arranged above the left side and the right side of the conveying channel 15, and the gap between each guide strip 16 and the conveying channel 15 is not less than the edge thickness of the reaction device plate 7.
In order to ensure the stability of the reaction device plate 7 in the conveying process, two guide strips 16 are respectively arranged on the left side and the right side of the conveying channel 15, the two guide strips 16 are both arranged in parallel to the conveying channel 15, and the length of each guide strip 16 is equal to that of the conveying channel 15. The two guide strips 16 are both positioned above the horizontal plane of the transmission channel 15, and the gap (namely the vertical height difference) between each guide strip 16 and the transmission channel 15 is not smaller than the edge thickness of the reaction device plate 7, so that the two ends of the reaction device plate 7 can be clamped in the gap between the guide strips 16 and the transmission channel 15, and the reaction device plate is always kept in a horizontal state in the transmission process, thereby ensuring the stability in the detection process and further being beneficial to improving the accuracy of the detection result. Simple structure, reasonable in design and transmission stability are good.
Preferably, in this embodiment, the width of the conveying channel 15 is smaller than the width between the left and right guide strips 16, so that the linear elevating motor 13 can drive the elevating push rod 14 to ascend from the gap between the conveying channel 15 and the guide strips 16 to the level of the reaction device plate 7, and then the stepping motor 9 drives the moving frame 12 to carry the reaction device plate 7 along the moving direction of the conveying channel 15.
According to the above technical scheme, the bracket 3 further comprises a left side plate, a right side plate, an upper beam 17 and at least one cross beam 18 for connecting the left side plate and the right side plate, the two guide strips 15 are respectively arranged on the left side plate and the right side plate, the upper beam 17 is arranged above the transmission channel 15 and the guide strips 16, and the detection device and the liquid feeding device are both arranged on the upper beam 17.
Further, in this embodiment, the bracket 3 further includes a left side plate, a right side plate and a cross beam 18, and the cross beam 18 is used for connecting the left side plate and the right side plate, so as to improve the structural stability of the whole bracket 3, and further, to be beneficial to ensuring that the sample can be always kept in a horizontal state in the conveying process; the number of the cross beams 18 can be multiple, the cross beams 18 can be arranged at certain intervals, and the number of the specific cross beams 18 and the interval between two adjacent cross beams 18 can be reasonably arranged and selected according to actual implementation conditions.
Further, in this embodiment, the bracket 3 further includes an upper beam 17, the upper beam 17 is located above the conveying channel 15 and the guide strip 16 and is parallel to the conveying channel 15, the upper beam 17 is provided with a placement hole, and the detecting device 6 and the liquid feeding device 4 can be fixed on the upper beam 15 through a positioning block. Wherein, locating piece accessible screw and resettlement hole fixed connection, simple structure, reasonable in design and fixed effectual.
Further, in this embodiment, the support 3 further includes a pillar 19, and the pillar 19 fixes the transmission path 15, the guide bar 16, and the upper beam 17 to the analyzer. Wherein, the quantity of pillar 19 can be a plurality of, and a plurality of pillars 19 can be set up in the bottom of transmission path 15 for central symmetry by transmission path's center to improve and fix transmission path 15, gib block 16 and upper beam 17 structural stability on the analysis appearance, do benefit to and ensure that the sample can remain the horizontality throughout in transportation.
According to the optimization of the technical scheme, the direction of the transmission channel from the sample feeding mechanism to the detection device is divided into an area A, an area B and an area C; the area A and the area B are respectively provided with a liquid feeding device and a conveying mechanism which operate independently, the starting end of the area A is provided with a first liquid feeding optical coupler, a first timing optical coupler and a first terminal optical coupler, and the terminal end P1 of the area A is provided with a first homing optical coupler and a second homing optical coupler; a second liquid feeding optical coupler, a second zero optical coupler and a second timing optical coupler are arranged at the starting end P2 of the area B, and a third resetting optical coupler and a detection optical coupler are arranged at the area C; the first end point optical coupler and the first homing optical coupler are respectively connected with a driving module of the A-zone transmission mechanism; the second homing optocoupler, the second end point optocoupler and the third homing optocoupler are respectively connected with a driving module of the transmission mechanism in the area B; and the first liquid adding optical coupler, the first timing optical coupler, the first end point optical coupler, the first homing optical coupler, the second end point optical coupler, the second liquid adding optical coupler, the second timing optical coupler, the second homing optical coupler, the third homing optical coupler and the detection optical coupler are respectively connected with the control device.
In this embodiment, the front and back sequence of the biochemical reactions of the sample is divided into the area a, the area B and the area C by using the boundary lines P0, P1, P2 and P3 as the boundary lines, the direction of the transmission channel 15 from the sample injection mechanism 1 to the detection device 6 is divided into the area a, the area B and the area C, the sample firstly undergoes the first biochemical reaction in the area a, then undergoes the second biochemical reaction in the area B, and finally undergoes the detection analysis in the area C; wherein the reaction time in zone A is longer than the reaction time in zone B. The A area and the B area are both provided with independent liquid feeding devices 4 and conveying mechanisms 2, the reaction device plate 7 moves on the conveying channel 15 and moves from the starting end (P0 position) of the conveying channel 15 to the terminal end (C position) of the conveying channel 15, and P1 positions, P2 positions and P3 positions are arranged between the P0 positions and the C positions, so that the A area is from the P0 position to the P1 position, and the B area is from the P2 position to the P3 position.
Specifically, in this embodiment, the automatic liquid adding device 4 in the area a is located at the position P0, and when the first liquid adding optical coupler at the position P0 detects the reaction device plate 7, the control device (central control circuit) controls the liquid adding device 4 to add a preset reaction liquid to the sample, and the first timing optical coupler measures the time of the first biochemical reaction. When the preset time T1 is reached, the control device (central control circuit) drives the linear lifting motor of the A-area conveying mechanism 2 to rotate 13 to drive the lifting push rod 14 to ascend until the stepping motor 9 rotates after the A-area lifting push rod 14 pushes against the horizontal plane of the reaction device plate 7, and the synchronous belt 10 drives the moving frame 12 to move to the end point P1 of the A-area. When the first homing optocoupler at the end of P1 detects the reaction device plate 7, the control device (central control circuit) drives the linear lifting motor 13 of the area A transmission mechanism 2 to rotate reversely to drive the lifting push rod 14 to descend, then the stepping motor rotates reversely, the synchronous belt 10 drives the moving frame 12 to drive the position P0 at the starting end of the area A, after the position P0 is reached, the baffle on the moving frame 12 of the area A is detected by the first end optocoupler arranged at the position P0, the stepping motor 9 of the area A transmission mechanism 2 is driven to stop rotating, and the moving frame 12 of the area A is stopped at the position P0.
When the first homing optocoupler at the end P1 detects the reaction device plate 7, the control device (central control circuit) starts a second end optocoupler arranged at the position P2, simultaneously drives the stepping motor 9 of the area B conveying mechanism 2 to rotate and drive the area B moving frame 12 to move towards the end P1 of the area A, and when the area B reaches the position P1, the linear lifting motor 13 of the area B conveying mechanism 2 is driven to rotate and drive the lifting push rod 14 to ascend until the lifting push rod 14 of the area B pushes against the horizontal plane of the reaction device plate 7, the baffle on the area B moving frame 12 is detected by the second homing optocoupler arranged at the position P1, the stepping motor 9 reversely rotates to drive the lifting push rod 14 to drive the reaction device plate 7 to move towards the position P2; after the position P2 is reached, the baffle on the moving frame 12 in the area B is detected by a second endpoint optical coupler arranged at the position P2, the linear lifting motor rotates 22 to drive the lifting push rod 23 to descend, and then the stepping motor stops rotating, so that the moving frame 12 in the area B stops at the position P2; when the second liquid adding optical coupler in the B area at the end P2 detects the reaction device plate 7, the control device (central control circuit) controls the automatic liquid adding device 4 to add the preset color developing liquid into the sample, and the second time optical coupler measures the time of the second biochemical reaction. When the preset time T2 is reached, (T1 > T2), the control device (namely, the central control circuit) drives the lifting motor 13 of the B area conveying mechanism 2 to rotate until the lifting push rod 14 of the B area pushes against the horizontal plane of the reaction device plate 7, then the stepping motor 9 rotates, drives the moving frame 12 to drive the reaction device plate 7 to move towards the C position, until the reaction device plate 7 is detected by the third homing optical coupler arranged in the C area, the linear lifting motor rotates 13 to drive the lifting push rod 14 to descend, the stepping motor 9 of the B area conveying mechanism 2 rotates reversely, so that the moving frame 12 of the B area moves towards the P2, and when the moving frame 12 of the B area is detected by the second endpoint optical coupler arranged in the P2, the moving frame 12 of the B area stops at the P2 position. And after the detection optical coupler at the C position detects the reaction device plate 7, the detection is started, and after the detection is finished, the detected optical signal is converted into a result through a control device 6 (a central control circuit) and is stored. Completing the detection step once.
Preferably, the optical couplers are all fixedly mounted on the upper beam 17. Specifically, the upper beam 17 is provided with a placement hole, the optical couplers can be fixed on the upper beam 17 through a positioning block matched with the placement hole, the positioning block is preferably fixed with the placement hole through a nut, the structure is simple, the production process is simple and convenient, and the fixing effect is good.
According to the optimization of the technical scheme, the liquid feeding device 4 comprises a peristaltic pump, a liquid feeding optical coupler, a liquid feeding pipeline and a liquid storage container, wherein the liquid feeding optical coupler is connected with the peristaltic pump, one end of the liquid feeding pipeline is immersed into a stock solution of the liquid storage container, and the other end of the liquid feeding pipeline is arranged towards the reaction device plate 7; the liquid storage container is provided with a temperature control module connected with the control device, and the temperature control module is used for setting corresponding storage temperature according to the storage conditions of different reaction liquids.
During the specific use, when reaction device board 7 removed to predetermineeing the liquid feeding department along transmission path 15, reaction device board 7 can be detected by the liquid feeding opto-coupler, and liquid feeding opto-coupler control peristaltic pump's single rotation, under the effect of pressure differential, with the deposit liquid drop of stock solution container to the sample in reaction device board 7 to accomplish the liquid feeding operation.
Further, the liquid storage container is also provided with a temperature control module which is connected with the control device, and the corresponding storage temperature can be set according to the storage conditions of different reaction liquids, so that the biochemical reaction can be always in the best reaction environment, and the accuracy of the detection result can be effectively improved.
According to the preferred technical scheme, the constant temperature heating device 5 comprises a PTC low-voltage heater and a low-voltage temperature control circuit, and the low-voltage temperature control circuit is respectively connected with the PTC low-voltage heater and the control device; the PTC low-voltage heater is arranged close to the bottom of the transmission channel 15, the reaction device plate 7 is arranged close to the upper surface of the transmission channel 15, and the transmission channel 15 is made of a heat-conducting material.
In this embodiment, the constant temperature heating device 5 includes a low-voltage temperature control circuit and a PTC low-voltage heater connected to the low-voltage temperature control circuit, the low-voltage temperature control circuit is connected to the control device, and according to the actual implementation condition of the specific biochemical reaction, the control device controls the heating temperature of the PTC low-voltage heater through the low-voltage temperature control circuit, specifically, the low-voltage temperature control circuit uploads the current temperature of the reaction device board 7 to the control device, and receives the temperature command set by the control device, so as to control the PTC low-voltage heater to perform the heating operation.
The transmission channel 15 is made of a heat conducting material, so that heat generated by the PTC low-voltage heater can be effectively transmitted to the reaction device plate 7, and the biochemical reaction can be ensured to be always in an optimal reaction environment. Preferably, in this embodiment, the transmission channel 15 is made of metal, so that the heat conduction effect is good, the structural strength of the whole transmission channel is improved, and the smooth proceeding of the whole transmission process is ensured.
Further, in order to prevent heat loss from the PTC low-voltage heater, all outer surfaces except the surface of the PTC low-voltage heater adjacent to the transmission passage 15 are surrounded by a thermal insulation plate and isolated from the outside. Preferably, in this embodiment, the PTC low-voltage heater is rectangular, except for the heating surface with the conveying channel 15, the other 5 surfaces are surrounded by the thermal insulation plate and separated from the outside, the structure is simple, the design is reasonable, the production process is simple and convenient, the heating effect is ensured, the production cost is reduced, and the economy is good.
According to the above technical scheme, preferably, the detection device 6 comprises a CCD light sensation detection device, the CCD light sensation detection device comprises a housing, an illumination light source, a light source control circuit, a CCD sensor and a signal processing circuit, the illumination light source, the light source control circuit, the CCD sensor and the signal processing circuit are arranged in the housing, the light source control circuit is connected with the illumination light source, and the light source control circuit and the signal processing circuit are respectively connected with the control device.
Specifically, in the present embodiment, the detection device is a CCD light sensing detection device, and the illumination light source is preferably an RGB three-color LED for providing the detection light source; the CCD is a charge coupled device and can convert an optical image reflected by a detected object into an electric signal, and a focusing condenser lens is arranged in front of the CCD and can adjust the focal length of the condenser lens. During detection, the light path structure adopting the standard d/0 condition (diffused illumination/vertical receiving) recommended by CIE1971 is that the illumination light source and the detected object form an angle d, and the CCD sensor is vertical to the detected object. The light source control circuit is a fixed three-terminal voltage stabilizing circuit and is used for providing stable voltage of the light source. The signal processing circuit is used for amplifying, resisting interference and performing AD conversion on the detected electric signals, wherein the signal processing circuit is connected with the control device and can upload the detected signals to the control device for storage, output and processing.
The illumination light source, the CCD sensor, the light source control circuit and the signal processing circuit are arranged in the shell, and the illumination light source, the CCD sensor, the light source control circuit and the signal processing circuit are integrated with the shell. In the detection process, a closed environment is formed by the detection object and the device, and the interference of external light is avoided.
Preferably, in this embodiment, the control device is a central control circuit, and includes a data memory and a data input/output device; the central control circuit is respectively connected with the conveying mechanism 2, the liquid feeding device 4, the constant temperature heating device 5 and the detection device 6 so as to collect feedback signals and send execution instructions.
According to the preferable technical scheme, the sample feeding mechanism 1 comprises a first pushing module and a second pushing module which is coplanar with the first pushing module and is perpendicular to the first pushing module, the starting end of the first pushing module is arranged at the inlet end of the analyzer, the terminal end of the first pushing module is the starting end of the second pushing module, and the terminal end of the second pushing module is arranged close to the transmission channel 15; first propelling movement module and second propelling movement module all include guide rail, linear electric motor, slider and opto-coupler, and when the opto-coupler detected original sample, linear electric motor drive slider took original sample to remove along the trend of guide rail.
In this embodiment, the sample feeding mechanism 1 includes a first pushing module and a second pushing module, wherein the first pushing module is disposed along the Y axis (i.e. the axis parallel to the width of the analyzer) to drive the reaction device plate 7 to move linearly along the Y axis direction; the second pushing module is disposed along the X-axis (an axis perpendicular to the horizontal plane with the Y-axis) to drive the reaction device plate 7 to move linearly along the X-axis direction.
Specifically, first propelling movement module and second propelling movement module all contain slider, guide rail, opto-coupler, baffle and linear electric motor, and when opto-coupler in the propelling movement module detected reaction device board 7, the baffle of locating on reaction device board 7 blocked the light path between the opto-coupler, and the opto-coupler sends start signal and gives linear electric motor, and linear electric motor drive slider takes original sample to remove along the trend of guide rail until closing on transmission channel 15. Simple structure, reasonable in design, degree of automation is high, and the harmony is good, can guarantee every sample at the uniformity of advancing the kind in-process, and the sample keeps the horizontality throughout advancing the kind in-process, ensures the stability in the testing process, and then does benefit to the accuracy that improves the testing result.
The preferred embodiment:
a sample containing vaginal secretion of a patient is added on the reaction device plate 7, and the reaction device plate 7 is brought to the position P0 at the beginning end of the A area of the transmission channel 15 by the sample injection mechanism 1. The liquid adding device 4 in the area A is arranged at the position P0, when the first liquid adding optical coupler in the area A at the position P0 detects the reaction device plate 7, the control device controls the liquid adding device 4 to add preset reaction liquid into the sample, and the first timing optical coupler arranged at the position P0 is used for metering the time of the first biochemical reaction. After the preset reaction time T1 of the first biochemical reaction is reached, the control device (i.e. the central control circuit) drives the linear lifting motor 13 of the A-zone conveying mechanism 2 to rotate so as to drive the lifting push rod 14 to ascend, the stepping motor 9 rotates after the A-zone lifting push rod 14 pushes against the horizontal plane of the reaction device plate 7, and the synchronous belt 10 drives the moving frame 12 to move to the P1 position of the A-zone terminal. When the reaction device plate is detected by a first homing optocoupler arranged at the position P1, the linear lifting motor 13 of the conveying mechanism 2 in the area A is driven to rotate reversely to drive the lifting push rod 14 to descend, the stepping motor 9 rotates reversely, and the synchronous belt 10 drives the moving frame 12 to drive to the position P0 at the starting point end of the area A; after reaching the position P0, the baffle on the area A moving rack 12 is detected by a first end optical coupler arranged at the position P0, and the stepping motor 9 of the area A conveying mechanism 2 is driven to stop rotating, so that the area A moving rack 12 stops at the position P0.
When the reaction device plate is detected by a first homing optocoupler arranged at the position P1, a stepping motor 9 of the B area conveying mechanism 2 is driven to rotate to drive the B area moving frame 12 to move towards the position P1 at the end point of the A area; after the position P1 is reached, the baffle on the moving frame 12 in the area B is driven to be detected by a second homing optical coupler arranged on the position P1, the linear lifting motor of the conveying mechanism 2 in the area B is driven to rotate 13 to drive the lifting push rod 14 to ascend, and the stepping motor 9 rotates reversely after the lifting push rod 14 in the area B is pushed against the horizontal plane of the reaction device plate 7 to drive the lifting push rod 14 to drive the reaction device plate 7 to face the position P2; when the baffle on the moving frame 12 of the driving B area conveying mechanism 2 is detected by the second end point optical coupler, the linear lifting motor 13 is rotated to drive the lifting push rod 14 to descend, then the stepping motor 9 stops rotating, so that the moving frame 12 of the B area stops at the position of P2, the reaction device plate 7 at the position of P2 is detected by the second liquid adding optical coupler at the B area of the P2 end, a preset color solution is added into a sample to carry out a second biochemical reaction, meanwhile, the reaction device plate 7 is detected by the second timing optical coupler at the position of P2, a second reaction timing is started, when the second reaction time detected by the second timing optical coupler reaches a preset time T2, (T1 is more than T2), the control device (namely, a central control circuit) drives the linear lifting motor 13 of the B area conveying mechanism 2 to rotate until the lifting push rod 14 of the B area pushes against the horizontal plane of the reaction device plate 7, then the stepping motor 9 rotates to drive the moving frame 12 to move towards the detection position of the C area, and when the reaction device plate 7 is detected by a third homing optical coupler arranged in the area C, the linear lifting motor rotates 13 to drive the lifting push rod 14 to descend, the stepping motor 9 rotates reversely to enable the movable frame 12 to move towards the position P2, and when the movable frame 12 is detected by a second terminal optical coupler arranged at the position P2, the movable frame in the area B stops at the position P2. And then, the detection optocoupler positioned at the C position detects that the reaction device plate 7 starts to detect, and after the detection is finished, the detected optical signal is converted into a result through the central control circuit and is stored. Thus, one detection step is completed.
After the reaction time T2 is finished, the central control circuit starts the zone B conveying mechanism to push the reaction device plate 7 on the P3 to the detection position C, if the position C has the reaction device plate 7 which is detected completely, the reaction device plate 7 provided with a new detection sample is pushed out of the analyzer, so that the continuous detection of a plurality of reaction device plates 7 is realized, the detection effect is ensured, and the detection efficiency is improved. The detection result is detected by the detection device 6 and is uploaded to the central control circuit for storage and reporting, and the detection process of one sample is completed.
In summary, the present invention provides an automatic analyzer for vaginal secretion, which comprises a control device, a liquid feeding device, a constant temperature heating device, and a sample injection mechanism, a transport mechanism and a detection device connected in sequence, wherein the control device is respectively connected with the liquid feeding device, the constant temperature heating device, the sample injection mechanism, the transport mechanism and the detection device; the liquid conveying device is used for adding a color development liquid and a reaction liquid into the original sample; the constant-temperature heating device is used for ensuring the temperature of biochemical reaction of the original sample, the color development liquid and the reaction liquid; the detection device carries out detection and analysis according to the result of the biochemical reaction. By adopting the automatic analyzer for vaginal secretion provided by the application, automatic sample introduction, transmission, liquid feeding and detection operations are realized through the control device, the automation degree is high, and the coordination is good; in the process of detecting the vaginal secretion, automatic sample feeding and sample adding can effectively avoid the uncertain factors caused by manual sample feeding and improve the detection precision; in addition, the analysis appearance that this application provided still is equipped with constant temperature heating device, can keep the required temperature of effectual biochemical reaction in real time, does benefit to further to improve and detects the precision, and simple structure, reasonable in design, it is easy and simple to handle, do benefit to the promotion of practicing thrift manpower resources and check-out time and detection efficiency, the practicality is strong, does benefit to and carries out standardized production and popularization.
Finally, it should be noted that: the above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present invention.

Claims (8)

1. An automatic analyzer for vaginal secretion, characterized in that: the device comprises a control device, a liquid feeding device, a constant temperature heating device, a sample feeding mechanism, a conveying mechanism and a detection device which are sequentially connected, wherein the control device is respectively connected with the liquid feeding device, the constant temperature heating device, the sample feeding mechanism, the conveying mechanism and the detection device;
the liquid feeding device is used for adding a reaction liquid and a color development liquid into an original sample; the constant-temperature heating device is used for ensuring the temperature of the biochemical reaction of the original sample with the reaction liquid and the color development liquid; the detection device carries out detection analysis according to the result of the biochemical reaction;
the device comprises a reaction device plate for placing the original sample and a bracket for fixedly mounting the control device, the liquid feeding device, the constant-temperature heating device, the sample feeding mechanism, the conveying mechanism and the detection device, wherein the bracket comprises a transmission channel, the conveying mechanism comprises a driving module, and the driving module drives the reaction device plate to move along the direction of the transmission channel;
the transmission channel is divided into an area A, an area B and an area C from the direction of the sample feeding mechanism pointing to the detection device; the area A and the area B are respectively provided with the liquid feeding device and the conveying mechanism which operate independently, the starting end of the area A is provided with a first liquid feeding optical coupler, a first timing optical coupler and a first terminal optical coupler, and the terminal end of the area A is provided with a first homing optical coupler and a second homing optical coupler; a second terminal optical coupler, a second liquid feeding optical coupler and a second timing optical coupler are arranged at the starting end of the area B, and a third homing optical coupler and a detection optical coupler are arranged in the area C;
the first end point optical coupler and the first homing optical coupler are respectively connected with a driving module of the A-zone transmission mechanism; the second homing optocoupler, the second end point optocoupler and the third homing optocoupler are respectively connected with a driving module of the B area transmission mechanism; and the first liquid adding optical coupler, the first timing optical coupler, the first end point optical coupler, the first homing optical coupler, the second end point optical coupler, the second liquid adding optical coupler, the second timing optical coupler, the second homing optical coupler, the third homing optical coupler and the detection optical coupler are respectively connected with the control device.
2. The vaginal secretion autoanalyzer according to claim 1, wherein: the driving module comprises a module main body, and a linear guide rail, a synchronous belt, a driven wheel, a stepping motor, a moving frame, a linear lifting motor and a lifting push rod which are arranged on the module main body; the linear lifting motor is connected with the lifting push rod, the linear lifting motor and the lifting push rod are both arranged on the moving frame, and the driven wheel is respectively connected with the stepping motor and the synchronous belt;
the moving frame is slidably arranged on the linear guide rail and comprises an embedding groove for embedding the synchronous belt; the linear lifting motor drives the lifting push rod to ascend until the lifting push rod pushes against the reaction device plate, and the stepping motor drives the moving frame to drive the reaction device plate to move along the moving direction of the transmission channel.
3. The vaginal secretion autoanalyzer according to claim 1, wherein: the support still includes two all along the direction of transmission path sets up the gib block, two the gib block coplane just locates respectively the top of transmission path left and right sides, and every the clearance between gib block and the transmission path is all not less than the edge thickness of reaction unit board.
4. The vaginal secretion autoanalyzer according to claim 3, wherein: the support further comprises a left side plate, a right side plate, an upper beam and at least one cross beam used for connecting the left side plate and the right side plate, the two guide strips are respectively arranged on the left side plate and the right side plate, the upper beam is arranged above the transmission channel and the guide strips, and the detection device and the liquid conveying device are both arranged on the upper beam.
5. The vaginal secretion autoanalyzer according to claim 1, wherein: the liquid feeding device comprises a peristaltic pump, a liquid feeding optical coupler, a liquid feeding pipeline and a liquid storage container, wherein the liquid feeding optical coupler is connected with the peristaltic pump, one end of the liquid feeding pipeline is immersed in a stock solution of the liquid storage container, and the other end of the liquid feeding pipeline is arranged towards the reaction device plate; the liquid storage container is provided with a temperature control module connected with the control device, and the temperature control module is used for setting corresponding storage temperature according to the storage conditions of different reaction liquids.
6. The vaginal secretion autoanalyzer according to claim 1, wherein: the constant temperature heating device comprises a PTC low-voltage heater and a low-voltage temperature control circuit, and the low-voltage temperature control circuit is respectively connected with the PTC low-voltage heater and the control device; the PTC low-voltage heater is tightly attached to the bottom of the transmission channel, the reaction device plate is tightly attached to the upper surface of the transmission channel, and the transmission channel is made of a heat-conducting material.
7. The vaginal secretion autoanalyzer according to claim 1, wherein: the detection device comprises a CCD light sensation detection device, the CCD light sensation detection device comprises a shell, an illumination light source, a light source control circuit, a CCD sensor and a signal processing circuit, the illumination light source, the light source control circuit, the CCD sensor and the signal processing circuit are arranged in the shell, the signal processing circuit is connected with the CCD sensor, the light source control circuit is connected with the illumination light source, and the light source control circuit and the signal processing circuit are respectively connected with the control device.
8. The vaginal secretion autoanalyzer according to claim 1, wherein: the sample feeding mechanism comprises a first pushing module and a second pushing module which is coplanar with the first pushing module and is perpendicular to the first pushing module, the starting end of the first pushing module is arranged at the inlet end of the analyzer, the terminal end of the first pushing module is the starting end of the second pushing module, and the terminal end of the second pushing module is arranged close to the transmission channel; the first pushing module and the second pushing module respectively comprise a guide rail, a linear motor, a sliding block and an optical coupler, and when the optical coupler detects the original sample, the linear motor drives the sliding block to drive the original sample to move along the trend of the guide rail.
CN201810205695.5A 2018-03-13 2018-03-13 Automatic analyzer for vaginal secretion Active CN110275030B (en)

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CN112553046B (en) * 2020-12-29 2024-06-14 安图实验仪器(郑州)有限公司 Automatic loading system for extraction strips

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