CN110261457A - Ion selective electrode electrolyte module - Google Patents

Abstract

The invention provides an ion-selective electrode electrolyte module, which includes an ion-selective electrode module, a pump module, and a reagent pack module. The liquid outlet of the reagent pack module passes through the connection between the pump module and the ion-selective electrode module. connected to the liquid inlet, the waste liquid outlet of the ion selective electrode module is connected to the waste liquid inlet of the reagent pack module through the pump module, the liquid inlet, waste liquid of the ion selective electrode module A liquid flow channel is communicated between the liquid outlets, and the liquid flow channel is perpendicular to the horizontal plane. The beneficial effects of the present invention are: the ion-selective electrode electrolyte module is used as a completely independent module, and together with the automatic biochemical analyzer, the probability of sample error can be greatly reduced; the flow path adopts a vertical flow path scheme, which can eliminate A and B Bubbles in the standard solution or sample, to prevent the air bubbles in the flow path from entering the electrode sample pipe and affecting the test results.

Description

Ion Selective Electrode Electrolyte Module

technical field

The invention relates to an electrolyte module, in particular to an ion selective electrode electrolyte module.

Background technique

At present, the domestic instrument used to measure the concentration of Li ⁺ , Na ⁺ , K ⁺ , and Cl ^- in serum, plasma, and diluted urine is a stand-alone electrolyte analyzer. The same sample is tested on both the electrolyte analyzer and the biochemical analyzer. In this way, the information is prone to error during the process of aliquoting or moving the sample. For large hospitals with a large number of samples, the single-machine electrolyte analyzer test requires a lot of manpower and material resources, which is inefficient and inconvenient.

Domestic stand-alone electrolyte analyzers such as Shanghai Schindler, Shenzhen Yuehua, Nanjing Panshida and other manufacturers generally use the sampling rack to complete the sample suction, and transport the sample to the flow cell through a section of pipeline for sampling. The flow path in the flow cell The method is horizontal, so that the entire flow path is long, and the air bubbles generated in the flow path pipe from the sampling needle to the front end of the flow cell are easily sucked into the electrode pipe of the flow cell, causing the electrode to be unstable and affecting the measurement results.

Personnel are required to maintain the electrodes, and the probability of electrode instability increases. The electrode filling liquid of the electrode used in the stand-alone electrolyte analyzer is used for a period of time, and the filling liquid decreases, which will lead to electrode instability, and the filling liquid of the electrode needs to be replaced manually, and the connection between the electrodes has no positioning structure, resulting in flow after assembly. It is easy to misplace between the paths, and the unsmoothness will cause the electrode to be unstable and affect the test results.

Contents of the invention

In order to solve the problems in the prior art, the invention provides an ion-selective electrode electrolyte module.

The invention provides an ion-selective electrode electrolyte module, which includes an ion-selective electrode module, a pump module, and a reagent pack module. The liquid outlet of the reagent pack module passes through the connection between the pump module and the ion-selective electrode module. connected to the liquid inlet, the waste liquid outlet of the ion selective electrode module is connected to the waste liquid inlet of the reagent pack module through the pump module, the liquid inlet, waste liquid of the ion selective electrode module A liquid flow channel is communicated between the liquid outlets, and the liquid flow channel is perpendicular to the horizontal plane.

As a further improvement of the present invention, the ion-selective electrode module includes a housing, and the housing is provided with a liquid inlet barrel assembly, a front-end liquid detector, an electrode assembly, a pressure plate, and a pressure plate adapter arranged in sequence along the liquid flow direction. The liquid inlet of the ion selective electrode module is arranged on the liquid inlet barrel assembly, and the liquid flow channel passes through the liquid inlet barrel assembly, the front-end liquid detector, the electrode assembly, the pressure plate and the pressure plate adapter in sequence, and the ion The waste liquid outlet of the selective electrode module is arranged on the pressure plate adapter.

As a further improvement of the present invention, the ion selective electrode module further includes an impedance plate and an electrode probe, and the electrode assembly is connected to the impedance plate through the electrode probe.

As a further improvement of the present invention, the electrode assembly includes at least two electrodes, the electrodes are stacked up and down perpendicular to the horizontal plane, the electrodes correspond to the electrode probes one by one, and the electrode probes are fixed on the shell In general, the electrode probe is connected to the impedance plate through a conductive shrapnel, and the electrode is in reliable contact with the electrode probe.

As a further improvement of the present invention, the adjacent electrodes are positioned and installed by a positioning structure, and a sealing ring is provided between the adjacent electrodes.

As a further improvement of the present invention, the liquid inlet barrel assembly and the front-end liquid detector are positioned and installed through a positioning structure, the front-end liquid detector and the electrode assembly are positioned and installed through a positioning structure, and the electrode assembly and the pressure plate are positioned and installed through a positioning structure. Positioning structure positioning installation.

As a further improvement of the present invention, a sealing ring is provided between the liquid inlet barrel assembly and the front-end liquid detector, a sealing ring is provided between the front-end liquid detector and the electrode assembly, and a sealing ring is provided between the electrode assembly and the pressure plate. lock up.

As a further improvement of the present invention, the positioning structure is a positioning structure in which a positioning protrusion cooperates with a positioning recess.

As a further improvement of the present invention, the reagent pack module includes a first type of standard liquid outlet, a second type of standard liquid outlet, a waste liquid inlet, and a chip for recording information such as the remaining amount of reagents, and the pump module Comprising a first peristaltic pump, a second peristaltic pump and a third peristaltic pump, the liquid inlet of the first peristaltic pump is connected to the second standard liquid outlet, and the liquid outlet of the first peristaltic pump is connected to the The liquid inlet barrel assembly is connected, the liquid inlet of the second peristaltic pump is connected to the first standard liquid outlet, and the liquid outlet of the second peristaltic pump is connected to the liquid inlet barrel assembly, The liquid inlet of the third peristaltic pump is connected to the pressure plate adapter, and the liquid outlet of the third peristaltic pump is connected to the waste liquid inlet.

As a further improvement of the present invention, the pressing plate is connected to the housing through a double torsion spring.

The beneficial effect of the present invention is: through the above scheme, the ion-selective electrode electrolyte module is used as a completely independent module, and together with the automatic biochemical analyzer, the probability of sample error can be greatly reduced, a large amount of manpower and material resources are saved, and the High efficiency, saving cost; the flow path adopts the vertical flow path scheme, which can eliminate the air bubbles in A, B standard liquid or sample, and prevent the air bubbles in the flow path pipe from entering the electrode sample pipe to affect the test results, and the flow path of this scheme is short , which can make the sample measurement faster, the electrode more stable, and save reagents, improve efficiency and save costs.

Description of drawings

Fig. 1 is a schematic diagram of an ion-selective electrode electrolyte module of the present invention.

Fig. 2 is a cross-sectional view of an ion-selective electrode module of an ion-selective electrode electrolyte module of the present invention.

Fig. 3 is a partial cross-sectional view of an ion-selective electrode module of an ion-selective electrode electrolyte module of the present invention.

Fig. 4 is a flow diagram of an ion selective electrode electrolyte module of the present invention.

Fig. 5 is a schematic diagram of an ion-selective electrode module of an ion-selective electrode electrolyte module of the present invention.

Fig. 6 is a schematic diagram of the front-end liquid detection of an ion selective electrode electrolyte module according to the present invention.

Fig. 7 is a schematic diagram of a pressing plate of an ion-selective electrode electrolyte module according to the present invention.

Detailed ways

The present invention will be further described below in conjunction with the description of the drawings and specific embodiments.

As shown in Figures 1 to 7, an ion-selective electrode electrolyte module includes an ion-selective electrode module 1, a pump module 2, and a reagent pack module 3, and the liquid outlet of the reagent pack module 3 passes through the pump module 2 is connected to the liquid inlet of the ion selective electrode module 1, and the waste liquid outlet of the ion selective electrode module 1 is connected to the waste liquid inlet of the reagent pack module 3 through the pump module 2 A liquid flow channel 111 is communicated between the liquid inlet and the waste liquid outlet of the ion selective electrode module 1 , and the liquid flow channel 111 is perpendicular to the horizontal plane.

As shown in Figures 1 to 7, the ion-selective electrode module 1 includes a housing 16, and the housing 16 is provided with a liquid inlet barrel assembly 11, a front-end liquid detector 12, and an electrode assembly arranged in sequence along the liquid flow direction. 13. The pressure plate 14 and the pressure plate adapter 15, the liquid inlet of the ion selective electrode module 1 is set on the liquid inlet barrel assembly 11, and the liquid flow channel 111 passes through the liquid inlet barrel assembly 11, the front end Liquid detector 12, electrode assembly 13, pressure plate 14 and pressure plate adapter 15, the waste liquid outlet of the ion selective electrode module 1 is arranged on the pressure plate adapter 15, and the flow channel 111 includes a flow channel and an electrode The sample testing pipeline, the liquid flow channel 111 is mainly composed of the liquid inlet barrel assembly 11 and the front liquid detector 12 , while the electrode sample testing pipeline is mainly composed of the electrode assembly 13 .

As shown in Figures 1 to 7, the ion-selective electrode module 1 also includes a main board 110, an impedance plate 17 and an electrode probe 18, and the electrode assembly 13 is connected to the impedance plate 17 through the electrode probe 18 .

As shown in FIGS. 1 to 7 , the electrode assembly 13 includes at least two electrodes, preferably five electrodes, the electrodes are stacked up and down perpendicular to the horizontal plane, and the electrodes correspond to the electrode probes 18 one by one. The electrode probe 18 is fixed on the housing 16 , the electrode probe 18 is connected to the impedance plate 17 through a conductive shrapnel, and the electrode 13 is in reliable contact with the electrode probe 18 .

As shown in FIG. 1 to FIG. 7 , the adjacent electrodes are positioned and installed through a positioning structure, and a sealing ring 112 is provided between the adjacent electrodes.

As shown in Figures 1 to 7, the liquid inlet barrel assembly 11 and the front-end liquid detector 1 are positioned and installed through a positioning structure, and the front-end liquid detector 12 and the electrode assembly 13 are positioned and installed through a positioning structure. The components 13 and the pressing plate 14 are positioned and installed through a positioning structure.

As shown in Figures 1 to 7, a seal ring 112 is provided between the liquid inlet barrel assembly 11 and the front end liquid detector 12, and a seal ring 112 is provided between the front end liquid detector 12 and the electrode assembly 13. A sealing ring 112 is provided between the assembly 13 and the pressing plate 14 .

As shown in Figures 1 to 7, the positioning structure is a positioning structure in which the positioning protrusion 113 is matched with the positioning depression 114. Taking the front-end liquid detector 12 as an example, there are flow path holes and positioning holes on the front-end liquid detector 12. There are positioning shafts 121 and positioning ribs 122 below. Taking the pressing plate 14 as an example, there are flow path holes, positioning holes 141 and positioning grooves 142 on the top of the pressing plate 14 .

As shown in Figure 4, the reagent pack module 3 includes a first standard liquid outlet (namely A standard liquid), a second standard liquid outlet (i.e. B standard liquid), a waste liquid inlet and a record A chip (L) for information such as reagent balance, the pump module 2 includes a first peristaltic pump 21, a second peristaltic pump 22, and a third peristaltic pump 23, and the liquid inlet of the first peristaltic pump 21 (that is, the I port ) is connected to the outlet of the second standard liquid, the outlet of the first peristaltic pump 21 (namely J port) is connected to the inlet barrel assembly 11, and the inlet of the second peristaltic pump 22 port (namely D port) is connected with the outlet port of the first standard liquid, the liquid outlet port (namely E port) of the second peristaltic pump 22 is connected with the liquid inlet barrel assembly 11, and the third peristaltic pump 22 The liquid inlet (ie port G) of the pump 23 is connected to the platen adapter 15, and the liquid outlet (ie port H) of the third peristaltic pump 23 is connected to the waste liquid inlet.

As shown in FIGS. 1 to 7 , the pressing plate 14 is connected to the housing through a double torsion spring 19 .

As shown in Figures 1 to 7, a kind of ion selective electrode electrolyte module provided by the present invention is a completely independent module, the MCU operation program of its main board 110, the serial port receives the user's operation information and sends it to the main board MCU for processing , control the operation of the three peristaltic pumps in the pump module 2, collect the analog channel data and convert, calculate, and the mainboard MCU transmits the test results to the PC.

As shown in Figures 1 to 7, the ion-selective electrode electrolyte module is used to measure the concentration of Li ⁺ , Na ⁺ , K ⁺ , and Cl ^- plasma in serum, plasma, and diluted urine, and the impedance board 17 and the main board 110 etc. The needle and the socket are directly connected, and the electrode is directly in reliable contact with the electrode probe 18 on the impedance plate 17 through the shrapnel, without cable connection, and the electrical noise can be minimized. The liquid inlet barrel assembly 11 is fixed together with the front-end liquid detector 12 through the housing 16 of the ion selective electrode module 1, and five electrode probes 18 are installed longitudinally in the housing 16. The number of electrode probes 18 is not limited to the one shown in the figure. The electrodes installed in the casing 16 are in reliable contact with the electrode probe 18, and the lower end of the bottommost electrode is the pressure plate 14 and the pressure plate adapter 15. The upper end of the pressure plate 14 has a positioning hole 141 and a positioning groove 142. There are flow holes. There are flow path holes, positioning holes, and positioning grooves in the middle part of the electrode, and there are positioning shafts and positioning ribs on the bottom. There are positioning shafts 121 and positioning ribs 122 at the lower end of the front-end liquid detector 12, and there are flow path holes in the middle. The above positioning structure can make the front-end liquid Detecting 12. When multiple electrodes are connected to the pressure plate 14, the flow path holes are automatically aligned to ensure smooth vertical flow paths and avoid unstable test data due to unsmooth flow paths. This vertical flow path scheme has a compact structure and a short flow path, which can prevent the air bubbles in the flow path pipeline from entering the electrode sampling pipeline and affect the test results. Moreover, this scheme has faster sampling speed, more stable electrodes, and saves reagents.

As shown in Figures 1 to 7, the working mode of an ion-selective electrode electrolyte module provided by the present invention is as follows:

The sample is sucked by the sampling needle of the automatic biochemical analyzer from the sample cup or the original blood collection tube placed at the corresponding position of the sample plate, and injected into the inner cavity of the liquid inlet barrel assembly 11 on the top of the ion selective electrode module 1. Bubbles are eliminated in the inner cavity of the liquid inlet barrel assembly 11 . The MCU operating program of the main board 110 of the ion selective electrode module 1, the serial port receives the user's operation information and transmits it to the MCU of the main board 110 for processing, and controls the operation of the third peristaltic pump 23, and the sample is moved to the vertically arranged electrode pipeline for sampling. The front end of the electrode is provided with a front-end liquid detector 12, which can detect bubbles in the liquid and whether there is or is no liquid, collect analog channel data and convert, calculate, and the MCU of the main board 110 transmits the test results to the PC. After the test is completed, the liquid The waste liquid (inlet) through the adapter box is sent to the waste liquid bag in the reagent pack. The sample flow path is: liquid inlet barrel assembly 11 (sample inlet) - front-end liquid detector 12 - electrode assembly 13 - pressure plate 14 - pressure plate adapter 15 - F-G-H - waste liquid from the adapter box.

Similarly, the A standard liquid is sucked from the A standard liquid of the adapter box on the reagent pack by the second peristaltic pump 22, and injected into the inner cavity of the liquid inlet barrel assembly 11 through A, and A is located on the side wall of the liquid inlet barrel assembly 11. At a distance of 2 mm from the upper end surface, the B standard liquid is sucked by the first peristaltic pump 21 from the B standard liquid of the adapter box on the reagent pack, and injected into the inner cavity of the liquid inlet barrel assembly 11 through B, and B is located on the side of the liquid inlet barrel assembly 11 At 3.7 mm directly below the wall A, after the air bubbles in the A and B standard liquids are injected into the inner cavity of the liquid inlet barrel assembly 11, they are automatically eliminated in this inner cavity and will not be sucked into the electrode pipeline at the lower end. With the cooperation of the third peristaltic pump 23, the B standard solution is sucked into the electrode pipelines arranged vertically at the lower end for sampling to complete the calibration or to clean the flow path. A standard liquid flow path: transfer box A standard liquid-D-E-inlet barrel assembly 11 A-front-end liquid detection 12-electrode assembly 13-press plate 14-press plate adapter 15-F-G-H-transition box waste liquid; B Standard liquid flow path: transfer box B standard liquid-I-J-B of the liquid inlet barrel assembly 11-front-end liquid detection 12-electrode assembly 13-press plate 14-press plate adapter 15-F-G-H-transition box waste liquid.

An ion-selective electrode electrolyte module provided by the present invention has the following beneficial effects compared with a traditional stand-alone electrolyte analyzer:

1. The flow path adopts a vertical flow path scheme. The liquid inlet barrel assembly 11 is directly connected to the front-end liquid detector 12 through the housing 16 of the ion-selective electrode module 1, and the front-end liquid detector 12 is directly connected to the pressure plate 14 through the vertically arranged electrode assembly 13. Connection, compact structure, the inner cavity of the liquid inlet barrel assembly 11 can eliminate the air bubbles in the A, B standard liquid or sample, and prevent the air bubbles in the flow path from entering the electrode sample pipe to affect the test results, and the flow path of this solution is short, It can make the sample test faster, the electrode is more stable, and the reagent is saved, which improves the efficiency and saves the cost;

2. The positioning structure can automatically align the flow path holes when the front-end liquid detector 12, multiple electrodes and the pressure plate 14 are connected to ensure smooth vertical flow paths, which can avoid unstable test data and affect test results due to unsmooth flow paths;

3. The inner filling liquid of the electrode can be replaced for more than three months, and the electrode does not require direct maintenance by personnel. It only needs to be cleaned periodically by the instrument, which saves manpower and avoids electrode instability when changing the inner filling liquid, which affects the test results. ;

4. As a completely independent module, the ion-selective electrode electrolyte module can greatly reduce the probability of sample errors together with the automatic biochemical analyzer, save a lot of manpower and material resources, and improve efficiency. Cost savings.

An ion-selective electrode electrolyte module provided by the present invention, as a completely independent module, is assembled on clinical testing equipment such as a fully automatic biochemical analyzer, and is used to measure Li ⁺ , Na ⁺ , Concentration of K ⁺ , Cl ^- plasma.

The above content is a further detailed description of the present invention in conjunction with specific preferred embodiments, and it cannot be assumed that the specific implementation of the present invention is limited to these descriptions. For those of ordinary skill in the technical field of the present invention, without departing from the concept of the present invention, some simple deduction or replacement can be made, which should be regarded as belonging to the protection scope of the present invention.

Claims (10)

1. a kind of ion selective electrode electrolyte module, it is characterised in that: including ion selective electrode module, pump module, Reagent packet module, the feed liquor that the liquid outlet of the reagent packet module passes through the pump module and the ion selective electrode module Mouth connection, the waste liquid that the waste liquid liquid outlet of the ion selective electrode module passes through the pump module and the reagent packet module Inlet connection, is communicated with flow liquid channel, the stream between the inlet of the ion selective electrode module, waste liquid liquid outlet Liquid channel is perpendicular to horizontal plane.

2. ion selective electrode electrolyte module according to claim 1, it is characterised in that: the ion selectivity electricity Pole module includes shell, is examined in the shell equipped with feed liquor tub assembly, the front end liquid being sequentially arranged along liquid flow direction, electrode The inlet of component, pressing plate and pressing plate adapter, the ion selective electrode module is arranged on the feed liquor tub assembly, institute It states flow liquid channel and passes sequentially through the feed liquor tub assembly, the inspection of front end liquid, electrode assembly, pressing plate and pressing plate adapter, the ion The waste liquid liquid outlet of electrodes selective module is arranged on the pressing plate adapter.

3. ion selective electrode electrolyte module according to claim 2, it is characterised in that: the ion selectivity electricity Pole module further includes impedance plate and electrode catheter, and the electrode assembly is connect by the electrode catheter with the impedance plate.

4. ion selective electrode electrolyte module according to claim 3, it is characterised in that: the electrode assembly includes At least two electrodes, the electrode are corresponded perpendicular to horizontal plane setting stacked on top of one another, the electrode and the electrode catheter, The electrode catheter is fixed on the housing, and the electrode catheter is connect by electroconductive elastic sheet with the impedance plate, the electricity Pole and the electrode catheter reliable contacts.

5. ion selective electrode electrolyte module according to claim 4, it is characterised in that: the adjacent electrode is logical Location structure location and installation is crossed, is equipped with sealing ring between the adjacent electrode.

6. ion selective electrode electrolyte module according to claim 2, it is characterised in that: the feed liquor tub assembly, By location structure location and installation between the inspection of front end liquid, is positioned and pacified by location structure between the front end liquid inspection, electrode assembly Dress passes through location structure location and installation between the electrode assembly, pressing plate.

7. ion selective electrode electrolyte module according to claim 6, it is characterised in that: the feed liquor tub assembly, It is equipped with sealing ring between the inspection of front end liquid, is equipped with sealing ring, the electrode assembly, pressing plate between the front end liquid inspection, electrode assembly Between be equipped with sealing ring.

8. ion selective electrode electrolyte module according to claim 6, it is characterised in that: the location structure is fixed The location structure that position protrusion is matched with locating recesses.

9. ion selective electrode electrolyte module according to claim 2, it is characterised in that: the reagent packet module packet Include the first standard liquid liquid outlet, second of standard liquid liquid outlet, waste liquid inlet and the chip for recording reagent information, the pump Module include the first peristaltic pump, the second peristaltic pump and third peristaltic pump, the inlet of first peristaltic pump with described second The connection of standard liquid liquid outlet, the liquid outlet of first peristaltic pump connect with the feed liquor tub assembly, second peristaltic pump into Liquid mouth is connect with the first described standard liquid liquid outlet, and the liquid outlet of second peristaltic pump is connect with the feed liquor tub assembly, institute The inlet for stating third peristaltic pump is connect with the pressing plate adapter, the liquid outlet of the third peristaltic pump and the waste liquid feed liquor Mouth connection.

10. ion selective electrode electrolyte module according to claim 2, it is characterised in that: the pressing plate passes through double Torsion spring is connect with the shell.