CN110251613A - A kind of compound preparation and preparation method thereof for treating hand decortication - Google Patents
A kind of compound preparation and preparation method thereof for treating hand decortication Download PDFInfo
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- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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Abstract
The present invention relates to a kind of compound preparations for treating hand decortication, by the material composition of following quality: 80~120g of compound dexamethasone acetate emulsifiable paste, 2~5g of VITAMIN C TABLET, 6~10g of bletilla, 6~10g of cortex dictamni, 8~12g of Asian puccoon, 0.4~0.8g of borneol.Above-mentioned formulation preparation method is as follows: (1) spare respectively by the VITAMIN C TABLET of above-mentioned quality, bletilla, cortex dictamni, Asian puccoon, borneol and grinding at 200~400 mesh fine-powdered particles.(2) the compound dexamethasone acetate emulsifiable paste of above-mentioned quality is poured into clean container, and is heated to 70 DEG C~80 DEG C.(3) above-mentioned powder is mixed, is added three times in container, stirred while adding, it is ensured that sufficiently fusion is cooled to room temperature to get the preparation is arrived.The product merges Chinese materia medica preparation that is natural, having no toxic side effect with Western medicine preparation, and safety is good, significant in efficacy, has filled up the blank of Disease Clinical treatment, wide market.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine preparation, and in particular to a kind of to treat the compound preparation and its preparation that hand is peeled
Method.
Background technique
Hand decortication is that there are many skin diseases caused by internal and external factor.Its symptom is hand excoriation, with the centre of the palm, is referred to
Web gap, finger tip are more common, and multiseriate epidermis can be damaged when serious, leads to sharp ache, affect patient's normal life.
It is general clinical to the therapeutic scheme of the disease, can only be by eczema progress conventional therapy, weak curative effect, side effect is more.
Summary of the invention
The compound preparation and preparation method thereof that hand is peeled is treated the purpose of the present invention is to provide a kind of,
To achieve the goals above, technical scheme is as follows.
A kind of compound preparation for treating hand decortication, by the material composition of following quality: compound dexamethasone acetate emulsifiable paste
80~120g, 2~5g of VITAMIN C TABLET, 6~10g of bletilla, 6~10g of cortex dictamni, 8~12g of Asian puccoon, 0.4~0.8g of borneol.
Above-mentioned formulation preparation method is as follows:
(1) respectively by the VITAMIN C TABLET of above-mentioned quality, bletilla, cortex dictamni, Asian puccoon, borneol and grinding at 200~400 mesh fine-powdereds
Particle, it is spare.
(2) the compound dexamethasone acetate emulsifiable paste of above-mentioned quality is poured into clean container, and is heated to 70 DEG C~80 DEG C.
(3) above-mentioned powder is mixed, is added three times in container, stirred while adding, it is ensured that sufficiently fusion is cooled to
Room temperature to get arrive the preparation.
Application method: said preparation is applied at hand decortication, can also uniformly be applied to palm part, and both hands friction allows
Drug sufficiently acts on skin of palm of hand.
Above-mentioned each component material action principle is as follows:
(1) compound dexamethasone acetate emulsifiable paste: said preparation is easily embrocated, easy to wash, does not pollute clothes.Cream has grease
Certain affinity can be mixed with surface of a wound exudate or secretion, on the normal function of skin without influence.Due to emulsifier surface
Active function and promote the contact area of drug and epidermis to increase, local drug concentration is high, and not cutaneous proper heat reduction has
The effect of protection lubrication anti-chap.Dexamethasone acetate has anti-inflammatory, anti-allergic effects in the present invention, can inhibit connective tissue
Hyperplasia reduces capillary wall and permeability of cell membranes, reduces inflammatory seepage discharge, inhibits histamine and the shape of other toxicants
At and release, formula in azone be highly effective skin penetrating agent, promote skin Dichlorodiphenyl Acetate dexamethasone absorption, and
There is sliding sense with skin contact.
(2) vitamin C: hand skin skin corium 75% is made of collagen, and fibrous collagen forms netted knot
Structure provides the tension and elasticity of skin；Meanwhile the collagen in skin corium is that epidermis conveys moisture.In collagen synthesis
When, the residues such as proline and lysine in polypeptide chain must be first under the catalysis of proline hydroxylase and lysyl hydroxylase
Hydroxylation is the residues such as hydroxyproline and hydroxylysine respectively.Vitamin C is these hydroxylases dimension as a kind of water soluble vitamin
One of cofactor necessary to activity is held, the collagen that can effectively facilitate structure organization generates, and helps aging damaged skin
Repairing and regeneration.When hypovitaminosis C, obstacle occurs for the synthesis of the cytoplasm such as collagen, it may occur that Chuan Mian ﹑ ulcer is not
Easily healing etc..
(3) bletilla: bitter, sweet, puckery, cold nature.With astringing to arrest bleeding, the effect of detumescence and promoting granulation is spitted blood, outside for spitting blood
Hurt bleeding, sore swollen toxin, chapped skin etc..Bletilla polysaccharide rich in bletilla, can be by promoting epidermal growth factor
Expression provides effective support attachment and growth to cell, when promoting the formation and reconstruction of wound epithelium, and being removed from wound,
It will not cause damaging again for cambium；Simultaneously its can also effective stimulus inflammatory cell infiltration, promote epithelial tissue formed, is fine
The synthesis for tieing up cell Proliferation and collagen, increases the synthesis and release of hydroxyproline, wound healing.
(4) cortex dictamni: it is bitter, it is cold in nature.With heat-clearing and damp-drying drug, wind-dispelling detoxify and other effects, cure mainly damp and hot sore, yellow water it is dripping,
Eczema, rubeola, scabies sore leprosy etc..Modern pharmacology shows cortex dictamni ligroin extraction to staphylococcus, Escherichia coli, common
Proteus, the inhibiting effect of hay bacillus are most strong, and main antibacterial substance is dictamine He fraxinellone；Cortex dictamni flooding agent is to violet
The skins such as trichophyta, Trichophyton concentricum, Microsporon audouini, oidium schoenleinii, microsporum ferrugineum are true
Bacterium has different degrees of inhibiting effect.
(5) Asian puccoon: it is sweet, salty, it is cold in nature.With cool blood, promoting blood circulation, the effect for promoting eruption of detoxifying.For treating allergic dermatitis, wet
Rash, cutaneous pruritus, nettle rash, rubeola, morbilli, erythema multiforme and psoriasis etc..Modern research suggests that alkannin and its derivative
Object, as the primary chemical constituent extracted from Chinese Drug Zicao, have it is anti-inflammatory, promote wound healing, antibacterial, it is antiviral,
Antitumor and immunological regulation, antibacterial, hemostasis and other effects.Effective component in alkannin is by inhibiting the high migration in macrophage
The expression of rate race albumen (HMGB) and the activity of core NF- κ signal beta transcription factor is reduced to have the function that its is anti-inflammatory.And it is wide
General efficient bacteriostasis, showing as it has inhibitory effect for staphylococcus aureus, Escherichia coli, typhoid bacillus etc..
At the same time, alkannin is contained by inhibiting the expression of Th1 cell factor to can promote inflammatory cell infiltration, fibroblast and collagen
Amount increases, and then promotes granulation tissue hyperplasia.
(6) borneol: pungent, bitter, cold nature.With inducing resuscitation of having one's ideas straightened out, the effect of heat-clearing dissipates poison, removing nebula, pyreticosis height is cured mainly
Hot coma, throat deafness, aphtha tooth swells, sore carbuncle infantile malnutrition due to digestive disturbances or intestinalparasites hemorrhoid, red eye, swell pain, pterygium etc..Site of action master of the borneol to skin
It not only can increase the Reservoir effect of intact skin and destratum corneum skin in cuticula, but also a variety of drugs can be promoted to penetrate
Skin absorb, and have the characteristics that be sustained, it is long-acting.But the concentration and borneol of borneol are in non-to the Transdermal absorption effect of drug is promoted
Linear relationship.In the present invention, it is suitable for containing that borneol is added can have promotion Cutaneous permeation effect to compound dexamethasone acetate emulsifiable paste
Amount about 0.5%.
Invention has the beneficial effects that: it peels patient 64 with hand within statistics nearly 3 years and is used as research object, at random
Be divided into observation group and control group, observation group is treated using compound preparation of the present invention, control group using treatment eczema common scheme into
Row treatment.The results show that using after present invention treatment 1 week, hand symptom of peeling improves obvious, and total effective rate is up to 93.8%；And
It is treated using treatment eczema common scheme, effect is not significant, total effective rate 37.5%.The product is by natural, nontoxic pair
The Chinese materia medica preparation of effect is merged with Western medicine preparation, and safety is good, significant in efficacy.The sky of Disease Clinical treatment is filled up
It is white, wide market.
Specific embodiment
A specific embodiment of the invention is described below with reference to embodiment, to better understand the present invention.
Embodiment 1
The compound preparation for the treatment of hand decortication in the present embodiment, by the material composition of following quality: compound dexamethasone acetate
Emulsifiable paste 80g, VITAMIN C TABLET 2g, bletilla 6g, cortex dictamni 6g, Asian puccoon 8g, borneol 0.4g.
Above-mentioned formulation preparation method is as follows:
(1) respectively by the VITAMIN C TABLET of above-mentioned quality, bletilla, cortex dictamni, Asian puccoon, borneol and grinding at 200 mesh fine-powdered particles,
It is spare.
(2) the compound dexamethasone acetate emulsifiable paste of above-mentioned quality is poured into clean container, and is heated to 70 DEG C.
(3) above-mentioned powder is mixed, is added three times in container, stirred while adding, it is ensured that sufficiently fusion is cooled to
Room temperature to get arrive the preparation.
Application method: said preparation is applied at hand decortication, can also uniformly be applied to palm part, and both hands friction allows
Drug sufficiently acts on skin of palm of hand.
Embodiment 2
The compound preparation for the treatment of hand decortication in the present embodiment, by the material composition of following quality: compound dexamethasone acetate
Emulsifiable paste 100g, VITAMIN C TABLET 3.5g, bletilla 7.5g, cortex dictamni 7.5g, Asian puccoon 10g, borneol 0.6g.
Above-mentioned formulation preparation method is as follows:
(1) respectively by the VITAMIN C TABLET of above-mentioned quality, bletilla, cortex dictamni, Asian puccoon, borneol and grinding at 300 mesh fine-powdered particles,
It is spare.
(2) the compound dexamethasone acetate emulsifiable paste of above-mentioned quality is poured into clean container, and is heated to 75 DEG C.
(3) above-mentioned powder is mixed, is added three times in container, stirred while adding, it is ensured that sufficiently fusion is cooled to
Room temperature to get arrive the preparation.
Application method: said preparation is applied at hand decortication, can also uniformly be applied to palm part, and both hands friction allows
Drug sufficiently acts on skin of palm of hand.
Embodiment 3
The compound preparation for the treatment of hand decortication in the present embodiment, by the material composition of following quality: compound dexamethasone acetate
Emulsifiable paste 120g, VITAMIN C TABLET 5g, bletilla 10g, cortex dictamni 10g, Asian puccoon 12g, borneol 0.8g.
Above-mentioned formulation preparation method is as follows:
(1) respectively by the VITAMIN C TABLET of above-mentioned quality, bletilla, cortex dictamni, Asian puccoon, borneol and grinding at 400 mesh fine-powdered particles,
It is spare.
(2) the compound dexamethasone acetate emulsifiable paste of above-mentioned quality is poured into clean container, and is heated to 80 DEG C.
(3) above-mentioned powder is mixed, is added three times in container, stirred while adding, it is ensured that sufficiently fusion is cooled to
Room temperature to get arrive the preparation.
Application method: said preparation is applied at hand decortication, can also uniformly be applied to palm part, and both hands friction allows
Drug sufficiently acts on skin of palm of hand.
The above is a preferred embodiment of the present invention, it is noted that for those skilled in the art
For, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications are also considered as
Protection scope of the present invention.
Claims (3)
1. a kind of compound preparation for treating hand decortication, it is characterised in that: by the material composition of following quality: filling in compound acetic acid
80~120g of the loose emulsifiable paste of rice, 2~5g of VITAMIN C TABLET, 6~10g of bletilla, 6~10g of cortex dictamni, 8~12g of Asian puccoon, borneol 0.4~
0.8g。
2. the compound preparation for the treatment of hand decortication according to claim 1, it is characterised in that: above-mentioned formulation preparation method is such as
Under:
(1) respectively by the VITAMIN C TABLET of above-mentioned quality, bletilla, cortex dictamni, Asian puccoon, borneol and grinding at 200~400 mesh fine-powdereds
Particle, it is spare；
(2) the compound dexamethasone acetate emulsifiable paste of above-mentioned quality is poured into clean container, and is heated to 70 DEG C~80 DEG C；
(3) above-mentioned powder being mixed, is added three times in container, stirred while adding, it is ensured that sufficiently fusion is cooled to room temperature,
Obtain the preparation.
3. the compound preparation for the treatment of hand decortication according to claim 1, it is characterised in that: the application method of above-mentioned preparation
For said preparation is applied at hand decortication, palm part can also be uniformly applied to, both hands friction allows drug sufficiently to act on
Skin of palm of hand.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910675122.3A CN110251613A (en) | 2019-07-25 | 2019-07-25 | A kind of compound preparation and preparation method thereof for treating hand decortication |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910675122.3A CN110251613A (en) | 2019-07-25 | 2019-07-25 | A kind of compound preparation and preparation method thereof for treating hand decortication |
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| CN110251613A true CN110251613A (en) | 2019-09-20 |
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ID=67928253
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| CN201910675122.3A Pending CN110251613A (en) | 2019-07-25 | 2019-07-25 | A kind of compound preparation and preparation method thereof for treating hand decortication |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117815281A (en) * | 2023-02-03 | 2024-04-05 | 胡飞宇 | Antipruritic pharmaceutical composition and preparation method thereof |
-
2019
- 2019-07-25 CN CN201910675122.3A patent/CN110251613A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117815281A (en) * | 2023-02-03 | 2024-04-05 | 胡飞宇 | Antipruritic pharmaceutical composition and preparation method thereof |
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