CN110251225B - A method for establishing a three-dimensional intersecting damage grid and a lesion damage system - Google Patents

Abstract

The embodiment of the present invention relates to a method for establishing a three-dimensional intersection damaged grid and a lesion damage system. The establishment method includes: determining that a node of the three-dimensional intersecting damaged grid is a contact point of an electrode; The contact distance of the two electrodes corresponding to the edge is less than or equal to the damage distance; based on the nodes and edges, a three-dimensional intersection damage grid is established. In the embodiment of the present invention, in the established three-dimensional cross damage grid, a dipole electric field can be formed between the electric shocks of the two electrodes corresponding to each edge, thereby forming a damage focus; and due to the contact distance between the two electrodes corresponding to the edge The damage distance is less than or equal to the damage distance, so that the damage focus is a continuous damage focus, so that the established three-dimensional cross damage grid increases the damage range of the damage focus and can completely cover the three-dimensional focus.

Description

A method for establishing a three-dimensional intersecting damage grid and a lesion damage system

technical field

Embodiments of the present invention relate to the technical field of lesion damage, and in particular, to a method for establishing a three-dimensional intersection damage grid, a lesion damage system, and a non-transitory computer-readable storage medium.

Background technique

Traditional stereotactic radiofrequency thermocoagulation has been widely criticized due to its small damage range, and it has not become an internationally recognized first-line treatment. Currently, for focal, distant epileptogenic foci, the best approach is to remove it. One such removal method is stereotactic radiofrequency thermocoagulation (RF-TC), which inactivates the skull by generating heat through a bipolar electric field located in the brain, usually at a temperature of 75-80°C. within the lesion tissue. This method was introduced in 1947 and has been used for a long time in epilepsy patients. However, conventional RF-TC methods cannot simultaneously record intracranial electrical activity.

Stereoelectroencephalography (SEEG) intracranial electrodes can be used to record intracranial EEG activity in patients with epilepsy. The report of radiofrequency thermal coagulation damage by this electrode was found in 2004, and this method is also used for the damage treatment of epileptogenic foci , the technology can record abnormal EEG, and can directly perform damage treatment in the brain without changing the electrode position. However, both traditional RF-TC and SEEG-guided RF-TC are not currently used internationally as first-line treatment for epileptogenic foci removal due to the small damage range.

In order to study how to expand the damage range, in recent years, the European Center of Epilepsy and the North American Center have successively discovered through egg white experiments that the dipole electric field formed by two contacts separated by a certain distance can significantly expand the damage range. However, worldwide, RF-TC still remains in a lower spatial dimension (one-dimensional), and the resulting lesions are sporadic and insufficient to completely cover naturally occurring epileptogenic foci. Moreover, egg whites are not homogeneous and contain many layers with different densities, which are not sufficient to fully reason about the detailed parameters of RF-TC.

The above description of the discovery process of the problem is only used to assist the understanding of the technical solution of the present invention, and does not mean that the above content is the prior art.

SUMMARY OF THE INVENTION

In order to solve at least one problem existing in the prior art, at least one embodiment of the present invention provides a method for establishing a three-dimensional intersection damage grid, a lesion damage system, and a non-transitory computer-readable storage medium.

To this end, in a first aspect, an embodiment of the present invention provides a method for establishing a three-dimensional intersection damaged grid, the method comprising:

Determine the nodes of the three-dimensional intersection damaged grid as the contacts of the electrodes;

Determine the edge of the three-dimensional intersection damage grid, and the contact distance of the two electrodes corresponding to the edge is less than or equal to the damage distance;

Based on the nodes and the edges, a three-dimensional intersection damage mesh is built.

In some embodiments, the determining the edges of the intersection damage mesh includes:

For the same electrode, if the contact distance between the same electrode and multiple electrodes is less than or equal to the damage distance, then it is determined that the same electrode corresponds to multiple sides, and the number of the multiple sides is the same as the number of the multiple electrodes. same number.

In some embodiments, the establishing the three-dimensional cross-damaged grid includes: arranging any two electrodes to be parallel or angled.

In some embodiments, the method further comprises: setting a damage parameter value of the three-dimensional intersection damage grid.

In some embodiments, the damage parameter values of the three-dimensional intersection damage grid include: electrode power and damage duration.

In some embodiments, the electrode power is 3 watts, and the damage duration is set to any value between 60 seconds and 80 seconds.

In some embodiments, the damage distance is 7 millimeters.

In a second aspect, an embodiment of the present invention further provides a lesion destruction system, including: a controller, a memory, a power source, and a plurality of electrodes;

the controller is connected to the memory and the power source, respectively;

the power source is connected to the plurality of electrodes;

The controller is configured to execute the steps of the method according to the first aspect by calling the program stored in the memory.

In a third aspect, an embodiment of the present invention further provides a non-transitory computer-readable storage medium, where the non-transitory computer-readable storage medium stores a program, and the program causes a computer to execute the steps of the method according to the first aspect.

It can be seen that in at least one embodiment of the present invention, in the established three-dimensional cross-damaged grid, a dipole electric field can be formed between the contacts of the two electrodes corresponding to each edge, thereby forming a damage focus; and because the edges correspond to The contact distance between the two electrodes is less than or equal to the damage distance, so that the damage focus is a continuous damage focus, so that the established three-dimensional cross damage grid increases the damage range of the damage focus and can completely cover the three-dimensional focus.

Description of drawings

In order to illustrate the technical solutions of the embodiments of the present invention more clearly, the following briefly introduces the accompanying drawings that need to be used in the description of the embodiments or the prior art. Obviously, the drawings in the following description are only some of the present invention. Embodiments For those of ordinary skill in the art, other drawings can also be obtained according to these drawings.

FIG. 1 is a flowchart of a method for establishing a three-dimensional intersection damage grid according to an embodiment of the present invention;

FIG. 2 is a structural block diagram of a system for lesion damage provided by an embodiment of the present invention.

Detailed ways

In order to understand the above objects, features and advantages of the present invention more clearly, the present invention will be further described in detail below with reference to the accompanying drawings and embodiments. It is to be understood that the described embodiments are some, but not all, embodiments of the present invention. The specific embodiments described herein are only used to explain the present invention, but not to limit the present invention. Based on the described embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art fall within the protection scope of the present invention.

In order to establish a damaged area sufficient to cover a three-dimensional lesion in a three-dimensional space, the inventor of the present application found that in the field of Computer Aided Design (CAD), there is a method for describing an object in a three-dimensional space, which is to use a three-dimensional model of the object. Meshlization. Therefore, the inventor of the present application proposes:

The RF-TC in three-dimensional space cannot rely only on the dipole electric field formed by a single pair of electrodes, but should rely on the Mesh Grid formed by the dipole electric field formed by multiple pairs of electrodes. The dipole electric field is formed by contacts on electrodes that are arranged differently (parallel or angled) at a distance. The contacts are equivalent to the nodes or vertices of the grid, and the dipole electric field between the contacts is equivalent to the edges of the grid. .

The inventor of the present application has carried out a large number of quantitative experiments to verify the properties of the nodes and edges mentioned in the above description, and named the above description as the theoretical system of three-dimensional intersection damage, and the grid mentioned in the above description is called three-dimensional intersection damage. grid.

The method for establishing a three-dimensional cross-destroyed grid disclosed in the embodiment can be used not only for eliminating/destroying lesions in an organism, but also for in vitro experiments and scientific research for non-diagnostic or therapeutic purposes. The method for establishing the three-dimensional intersection damaged grid provided by the present invention is not limited to clinical application.

1 is a flowchart of a method for establishing a three-dimensional intersection damage grid provided by an embodiment of the present invention, and the method may include the following steps 101 to 103:

101. Determine the nodes of the three-dimensional intersection damaged grid as the contacts of the electrodes.

102. Determine the edge of the three-dimensional intersection damage grid, where the contact distance between the two electrodes corresponding to the edge is less than or equal to the damage distance.

103. Based on nodes and edges, establish a three-dimensional intersection damage grid.

In this embodiment, the three-dimensional intersection damage mesh is a three-dimensional mesh (3D mesh). It can be understood that the nodes of the three-dimensional cross-damaged grid are used to set electrodes, which indirectly indicates that the nodes are used to set the contacts of the electrodes, that is, in the process of establishing the three-dimensional cross-damaged grid, the nodes can be virtual nodes. After the grid, set the electrode at the position of the node.

In some embodiments, establishing the three-dimensional cross-destruction grid includes arranging any two electrodes to be parallel or angled. Through the contact of two parallel or angled electrodes, a dipole electric field can be formed, and thus a lesion foci.

The inventor of the present application found that the contact distance between the two electrodes affects the continuity of the lesion. Specifically, the critical distance between the continuation of the lesion and the separation of the lesion is called the damage distance.

If the contact distance of the two electrodes is greater than the damage distance, a continuous damage focus cannot be formed between the contacts of the two electrodes, and the damage volume is significantly reduced.

If the contact distance of the two electrodes is less than or equal to the damage distance, a continuous damage focus is formed between the contacts of the two electrodes, and the inventors of the present application found that within the damage distance, the larger the contact distance, the greater the damage range. , although the intensity of the lesions is reduced, the temperature of the lesions is still sufficient to cause irreversible tissue inactivation.

In some embodiments, determining the edges of the intersection damage mesh includes:

For the same electrode, if the contact distance between the same electrode and multiple electrodes is less than or equal to the damage distance, then it is determined that the same electrode corresponds to multiple sides, and the number of the multiple sides is the same as the number of the multiple electrodes. same number.

The inventors of the present application found that, in the thermal coagulation damage, the contact of the same electrode can form a continuous damage zone multiple times with the contacts of different electrodes within the surrounding damage distance. Attributes.

In some embodiments, the method for establishing a three-dimensional intersection damage grid may further include the step of: setting a damage parameter value of the three-dimensional intersection damage grid. The damage parameter values of the three-dimensional intersection damage grid include but are not limited to: electrode power and damage duration. Setting the damage parameter values can be performed after the stereocross damage mesh is created, before the process starts, or during the creation process.

The inventors of the present application have found that, through the contacts of two parallel or angled electrodes, with an electrode power of 3 watts and a damage time of 150 seconds, the contact spacing is within 7 mm (that is, the damage distance is 7 mm, and the contact distance is 7 mm and the contact distance is 7 mm). point spacing ≤ damage distance), a dipole electric field can be formed, and then a continuous damage focus can be formed. The temperature of the lesions was between 65°C and 82°C.

The inventors of the present application found that when the contact distance is within 7 mm, the larger the contact distance is, the larger the damage range is, but the damage intensity is reduced. But even if the damage is reduced in intensity, the resulting temperature is still sufficient to cause irreversible inactivation of the tissue. However, when the contact distance is greater than 7 mm, for example, 9 mm, continuous damage cannot be formed, and the damage volume is significantly reduced.

The inventors of the present application also found that when the contact distance is less than 7 mm, there is a plateau in the growth of the lesion diameter of the lesion. The plateau usually occurs within 60 seconds after the damage starts, and a long-term observation of 750 seconds after the plateau occurs. , it was found that the lesion diameter increased only by a factor of 1.3 to 1.4. Therefore, the inventor of the present application proposes that when the three-dimensional intersection is damaged, when the contact distance is less than 7 mm, it should be dispersed as much as possible to achieve the largest damage range. The damage duration is set to any value between 60 seconds and 80 seconds, that is, 60 seconds≤damage duration≤80 seconds.

It can be seen that in the three-dimensional intersecting damage grid established in the above embodiment, a dipole electric field can be formed between the contacts of the two electrodes corresponding to each edge, thereby forming a damage focus; and the distance between the contacts of the two electrodes corresponding to the edge The damage distance is less than or equal to the damage distance, so that the damage focus is a continuous damage focus, so that the established three-dimensional cross damage grid increases the damage range of the damage focus and can completely cover the three-dimensional focus.

In addition, the three-dimensional intersecting damage grid established in the above embodiment changes the current traditional damage system that is limited to low spatial dimensions and cannot effectively cover three-dimensional lesions; the damage process fully covers the three-dimensional damage space, which significantly expands the damage range of three-dimensional lesions. .

FIG. 2 is a schematic structural diagram of a lesion destruction system provided by an embodiment of the present invention.

The lesion destruction system shown in FIG. 2 includes: a controller 201, a memory 202, a power source 204 and a plurality of electrodes 205. To simplify the illustration, only one electrode 205 is shown in FIG. 2, and the number of electrodes 205 can be based on actual needs Make settings. The controller 201 is respectively connected to the memory 202 and the power source 204 ; the power source 204 is connected to the plurality of electrodes 205 .

The controller 201 can control the power source 204 to provide 3 watts of electrode power to the plurality of electrodes 205, the electrode power duration is controlled to be 150 seconds, and the damage duration is 150 seconds, and the contact distance of the electrodes is within 7 mm (that is, the damage distance is 150 seconds). 7 mm, and the contact distance ≤ damage distance), a dipole electric field can be formed, and then a continuous damage focus can be formed. The temperature of the lesions was between 65°C and 82°C.

In some embodiments, the lesion destruction system may include multiple controllers 201 and multiple memories 202, the number of which can be set according to actual needs. The various components in the lesion destruction system may be coupled together by the bus system 203 . It can be understood that the bus system 203 is used to realize the connection and communication between these components. In addition to the data bus, the bus system 203 also includes a power bus, a control bus and a status signal bus. However, for the sake of clarity, the various buses are labeled as bus system 203 in FIG. 2 .

It is understood that the memory 202 in this embodiment may be a volatile memory or a non-volatile memory, or may include both volatile and non-volatile memory. Wherein, the non-volatile memory may be Read-Only Memory (ROM), Programmable Read-Only Memory (Programmable ROM, PROM), Erasable Programmable Read-Only Memory (Erasable PROM, EPROM), Electrically Erasable Memory Except programmable read-only memory (Electrically EPROM, EEPROM) or flash memory. The volatile memory may be random access memory (RAM), which is used as an external cache. By way of example and not limitation, many forms of RAM are available, such as Static RAM (SRAM), Dynamic RAM (DRAM), Synchronous DRAM, SDRAM), double data rate synchronous dynamic random access memory (DoubleDataRateSDRAM, DDRSDRAM), enhanced synchronous dynamic random access memory (Enhanced SDRAM, ESDRAM), synchronous link dynamic random access memory (Synchlink DRAM, SLDRAM) and direct memory Bus random access memory (DirectRambus RAM, DRRAM). The memory 202 described herein is intended to include, but not be limited to, these and any other suitable types of memory.

In this embodiment of the present invention, the controller 201 is configured to execute the steps of each embodiment of the method by calling a program stored in the memory 202, for example, the following steps 1 to 3 may be included:

Step 1: Determine the nodes of the three-dimensional intersection damaged grid as the contacts of the electrodes.

Step 2: Determine the edge of the three-dimensional intersection damage grid, and the contact distance between the two electrodes corresponding to the edge is less than or equal to the damage distance.

Step 3: Based on the nodes and the edges, establish a three-dimensional intersection damage grid.

The methods disclosed in the above embodiments of the present invention may be applied to the controller 201 or implemented by the controller 201 . The controller 201 may be an integrated circuit chip with signal processing capability. In the implementation process, each step of the above-mentioned method can be completed by an integrated logic circuit of hardware in the controller 201 or an instruction in the form of software. The above-mentioned controller 201 may be a general-purpose processor, a digital signal processor (Digital Signal Processor, DSP), an application specific integrated circuit (ASIC), an off-the-shelf programmable gate array (FieldProgrammable Gate Array, FPGA), or other available Programming logic devices, discrete gate or transistor logic devices, discrete hardware components. Various methods, steps, and logical block diagrams disclosed in the embodiments of the present invention can be implemented or executed. A general purpose processor may be a microprocessor or the processor may be any conventional processor or the like. The steps of the method disclosed in conjunction with the embodiments of the present invention may be directly embodied as executed by a hardware decoding processor, or executed by a combination of hardware and software units in the decoding processor. The software unit may be located in random access memory, flash memory, read-only memory, programmable read-only memory or electrically erasable programmable memory, registers and other storage media mature in the art. The storage medium is located in the memory 202, and the controller 201 reads the information in the memory 202, and completes the steps of the above method in combination with its hardware.

It can be understood that, the units and algorithm steps of each example described in conjunction with the embodiments disclosed herein can be implemented by electronic hardware, or a combination of computer software and electronic hardware. Whether these functions are performed in hardware or software depends on the specific application and design constraints of the technical solution. Skilled artisans may implement the described functionality using different methods for each particular application, but such implementations should not be considered beyond the scope of the present invention.

Those skilled in the art can clearly understand that, for the convenience and brevity of description, the specific working process of the above-described systems, devices and units may refer to the corresponding processes in the foregoing method embodiments, which will not be repeated here.

In the embodiments provided in this application, it should be understood that unless there is a clear sequence between steps in the method embodiments, the execution sequence can be adjusted arbitrarily. The disclosed apparatus and method can be implemented in other ways. For example, the apparatus embodiments described above are only illustrative. For example, the division of the units is only a logical function division. In actual implementation, there may be other division methods. For example, multiple units or components may be combined or Can be integrated into another system, or some features can be ignored, or not implemented. On the other hand, the shown or discussed mutual coupling or direct coupling or communication connection may be through some interfaces, indirect coupling or communication connection of devices or units, and may be in electrical, mechanical or other forms.

The units described as separate components may or may not be physically separated, and components displayed as units may or may not be physical units, that is, may be located in one place, or may be distributed to multiple network units. Some or all of the units may be selected according to actual needs to achieve the purpose of the solution in this embodiment.

In addition, each functional unit in each embodiment of the present invention may be integrated into one processing unit, or each unit may exist physically alone, or two or more units may be integrated into one unit.

The functions, if implemented in the form of software functional units and sold or used as independent products, may be stored in a computer-readable storage medium. Based on this understanding, the technical solutions of the embodiments of the present invention are essentially, or the parts that make contributions to the prior art or the parts of the technical solutions can be embodied in the form of software products, and the computer software products are stored in a storage medium , including several instructions for causing a computer device (which may be a personal computer, a server, or a network device, etc.) to execute all or part of the steps of the methods described in the various embodiments of the present invention. The aforementioned storage medium includes: a U disk, a removable hard disk, a ROM, a RAM, a magnetic disk, or an optical disk and other mediums that can store program codes.

An embodiment of the present invention further provides a non-transitory computer-readable storage medium, where the non-transitory computer-readable storage medium stores a program, and the program causes a computer to execute the steps of the various embodiments of the method, for example, the following steps 1 to Step 3:

Step 1: Determine the nodes of the three-dimensional intersection damaged grid as the contacts of the electrodes.

Step 2: Determine the edge of the three-dimensional intersection damage grid, and the contact distance between the two electrodes corresponding to the edge is less than or equal to the damage distance.

Step 3: Based on the nodes and the edges, establish a three-dimensional intersection damage grid.

It should be noted that, herein, the terms "comprising", "comprising" or any other variation thereof are intended to encompass non-exclusive inclusion, such that a process, method, article or device comprising a series of elements includes not only those elements, It also includes other elements not expressly listed or inherent to such a process, method, article or apparatus. Without further limitation, an element qualified by the phrase "comprising a..." does not preclude the presence of additional identical elements in a process, method, article or apparatus that includes the element.

It will be understood by those skilled in the art that although some of the embodiments described herein include certain features, but not others, included in other embodiments, that combinations of features of the different embodiments are intended to be within the scope of the present invention And form different embodiments.

Although the embodiments of the present invention have been described with reference to the accompanying drawings, various modifications and variations can be made by those skilled in the art without departing from the spirit and scope of the present invention, and such modifications and variations all fall within the scope of the appended claims within the limits of the requirements.

Claims (9)

1. a method for establishing a three-dimensional intersection damage grid, is characterized in that, comprising: Determine the nodes of the three-dimensional intersection damaged grid as the contacts of the electrodes; Determine the edge of the three-dimensional intersection damage grid, and the contact distance between the two electrodes corresponding to the edge is less than or equal to the damage distance; wherein, the critical distance between the continuity of the damaged focus and the separation of the damaged focus is taken as the damage distance; Based on the nodes and the edges, a three-dimensional intersection damage mesh is built. 2 . The method according to claim 1 , wherein the determining the edge of the three-dimensional intersection damaged mesh comprises: 2 . For the same electrode, if the contact distance between the same electrode and multiple electrodes is less than or equal to the damage distance, then it is determined that the same electrode corresponds to multiple sides, and the number of the multiple sides is the same as the number of the multiple electrodes. same number. 3 . The method according to claim 1 , wherein the establishing the three-dimensional cross-damaged grid comprises: arranging any two electrodes to be parallel or angled. 4 . 4 . The method according to claim 1 , further comprising: setting a damage parameter value of the three-dimensional intersection damage grid. 5 . 5 . The method according to claim 4 , wherein the damage parameter value of the three-dimensional intersection damage grid includes: electrode power and damage duration. 6 . 6 . The method of claim 5 , wherein the electrode power is 3 watts, and the damage duration is set to any value between 60 seconds and 80 seconds. 7 . 7. The method according to any one of claims 1 to 6, wherein the damage distance is 7 mm. 8. A lesion destruction system, comprising: a controller, a memory, a power source and a plurality of electrodes; the controller is connected to the memory and the power source, respectively; the power source is connected to the plurality of electrodes; The controller is configured to execute the steps of the method according to any one of claims 1 to 7 by invoking a program stored in the memory. 9. A non-transitory computer-readable storage medium, characterized in that the non-transitory computer-readable storage medium stores a program, the program causing a computer to execute the steps of the method according to any one of claims 1 to 7 .

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