CN110205245B

CN110205245B - Cell reactor for biological artificial liver support system

Info

Publication number: CN110205245B
Application number: CN201910516506.0A
Authority: CN
Inventors: 吕国军
Original assignee: Kexian Medical Science And Technology Suzhou Co ltd
Current assignee: Kexian Medical Science And Technology Suzhou Co ltd
Priority date: 2019-06-14
Filing date: 2019-06-14
Publication date: 2022-07-08
Anticipated expiration: 2039-06-14
Also published as: CN110205245A

Abstract

The invention provides a cell reactor for a biological artificial liver support system, which comprises a cylinder body; the cylinder body is hollow cylindrical, two ends of the cylinder body are respectively provided with a pulp conveying port, two ends of the inside of the cylinder body are respectively provided with a screen device, a plurality of hepatocyte microcapsules are arranged in the cylinder body, and the hepatocyte microcapsules are arranged between the two screen devices. The cell reactor for the biological artificial liver support system is matched with the cylinder body, the sieve tray and the guide column, so that the plasma can generate a guide effect when flowing in the cell reactor, the accumulation of the hepatocyte microcapsules at the sieve tray is effectively reduced, the stability and the filtering effect of the plasma passing through the cell reactor are improved, and the possibility of the hepatocyte microcapsules being broken is reduced.

Description

Cell reactor for biological artificial liver support system

Technical Field

The invention belongs to the field of medical instruments, and particularly relates to a cell reactor for a biological artificial liver support system.

Background

Because of the biological artificial liver technology, the blood purification effect of patients is better and the side effect is smaller, so the biological artificial liver medical equipment becomes the main development trend, and the cell reactor used by the biological artificial liver directly influences the blood filtration effect. Under the prior art, the microcapsule type cell reactor is generally directly perfused by a fixed bed, so that the hepatocyte microcapsules are easily accumulated at the screen meshes at two ends in the cell reactor to cause the flowing blockage of plasma, and the surface of the hepatocyte microcapsules is easily and continuously pressurized to cause the damage of the capsules.

Disclosure of Invention

In view of this, the present invention aims to provide a cell reactor for a biological artificial liver support system, which, in cooperation with a cylinder, a sieve tray and a guide column, can generate a guiding effect when plasma flows in the cell reactor, effectively reduce the accumulation of hepatocyte microcapsules on the sieve tray, improve the stability and filtering effect of plasma passing through the cell reactor, and reduce the possibility of hepatocyte microcapsule breakage.

In order to achieve the purpose, the technical scheme of the invention is realized as follows:

a cell reactor for a biotype artificial liver support system comprises a cylinder body; the cylinder body is hollow and cylindrical, two ends of the cylinder body are respectively provided with a pulp conveying port, two ends of the inside of the cylinder body are respectively provided with a screen device, a plurality of hepatocyte microcapsules are arranged in the cylinder body, and the hepatocyte microcapsules are arranged between the two screen devices; the screen device includes: a sieve tray and a guide post; the diameter of the sieve tray is equal to the inner diameter of the cylinder, the sieve tray is fixedly connected with the inner wall of the cylinder in a sealing way, and a plurality of pulp passing through holes are formed in the sieve tray; the guide column is hollow and cylindrical, one end of the guide column is fixedly connected with the central position of the inner side of the sieve tray, the sieve tray is arranged in a sealing way at the position coinciding with the circular bottom surface of the guide column, the other end of the guide column covers the flexible sieve mesh, the diameter of the mesh of the flexible sieve mesh is smaller than that of the hepatocyte microcapsule, and the side wall of the guide column is provided with a plurality of flow guide through holes; the water conservancy diversion through-hole sets up with the sieve tray is adjacent, and two guide posts set up relatively.

Furthermore, the middle part of the cylinder body is provided with a loading port for placing the hepatocyte microcapsules.

Furthermore, four guide through holes are formed in the same guide column, and the four guide through holes are symmetrically arranged by taking the axis of the guide column as a center.

Further, the sieve tray is a flexible material sieve tray.

Further, the hepatocyte microcapsules were loaded to 50% of the volume inside the cartridge.

Furthermore, two slurry conveying ports are provided with quick connecting joints.

Furthermore, the cylinder body is wrapped with a heat-insulating layer.

Furthermore, the heat-insulating layer is a foaming heat-insulating layer.

Further, the length of the cylinder is 3 times of the inner diameter of the cylinder.

Furthermore, the surface of the flow guide through hole is provided with a barrier net for blocking the liver cell microcapsules from entering.

Compared with the prior art, the cell reactor for the biological artificial liver support system has the following advantages:

the cell reactor for the biological artificial liver support system is matched with the cylinder body, the sieve tray and the guide column, so that the plasma can generate a guide effect when flowing in the cell reactor, the accumulation of the hepatocyte microcapsules at the sieve tray is effectively reduced, the stability and the filtering effect of the plasma passing through the cell reactor are improved, and the possibility of the hepatocyte microcapsules being broken is reduced.

Drawings

The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate an embodiment of the invention and, together with the description, serve to explain the invention and not to limit the invention.

In the drawings:

FIG. 1 is a schematic diagram of a cell reactor for a bio-based artificial liver support system according to an embodiment of the present invention;

FIG. 2 is a schematic right view of a cell reactor for use in a bio-based artificial liver support system according to an embodiment of the present invention;

FIG. 3 is a schematic front view of a cell reactor for use in a bio-based artificial liver support system according to an embodiment of the present invention;

FIG. 4 is a first schematic view of a screen arrangement inside a cell reactor for a bio-based artificial liver support system according to an embodiment of the present invention;

FIG. 5 is a second schematic view of an arrangement of a screen device inside a cell reactor for a bio-based artificial liver support system according to an embodiment of the present invention;

FIG. 6 is a schematic top view of a cell reactor screen assembly for use in a bio-based artificial liver support system according to an embodiment of the present invention;

FIG. 7 is a schematic diagram of a cell reactor screen device for a bio-based artificial liver support system according to an embodiment of the present invention.

Description of reference numerals:

1-a cylinder body; 2-a pulp conveying port; 3-a loading port; 4-a screen device; 41-a sieve tray; 42-guide post.

Detailed Description

It should be noted that the embodiments and features of the embodiments may be combined with each other without conflict.

In the description of the present invention, it is to be understood that the terms "center", "longitudinal", "lateral", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", and the like, indicate orientations or positional relationships based on those shown in the drawings, and are used only for convenience in describing the present invention and for simplicity in description, and do not indicate or imply that the referenced devices or elements must have a particular orientation, be constructed and operated in a particular orientation, and thus, are not to be construed as limiting the present invention. Furthermore, the terms "first", "second", etc. are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first," "second," etc. may explicitly or implicitly include one or more of that feature. In the description of the present invention, "a plurality" means two or more unless otherwise specified.

In the description of the present invention, it should be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the present invention can be understood by those of ordinary skill in the art through specific situations.

The present invention will be described in detail below with reference to the embodiments with reference to the attached drawings.

As shown in fig. 1 to 7, a cell reactor for a biotype artificial liver support system comprises a cylinder body 1; the device comprises a barrel body 1, a plurality of screening devices 4, a plurality of hepatocyte microcapsules and a filter, wherein the barrel body 1 is hollow and cylindrical, two ends of the barrel body 1 are respectively provided with a pulp conveying port 2, two ends of the interior of the barrel body 1 are respectively provided with one screening device 4, and the hepatocyte microcapsules are arranged between the two screening devices 4; the screen device 4 includes: a sieve tray 41 and a guide post 42; the diameter of the sieve tray 41 is equal to the inner diameter of the cylinder 1, the sieve tray 41 is fixedly connected with the inner wall of the cylinder 1 in a sealing manner, and a plurality of pulp passing through holes are formed in the sieve tray 41; the guide column 42 is hollow cylindrical, one end of the guide column 42 is fixedly connected with the central position of the inner side of the sieve tray 41, the coincident position of the sieve tray 41 and the circular bottom surface of the guide column 42 is sealed, the other end of the guide column 42 is covered with a flexible screen, the diameter of a mesh of the flexible screen is smaller than that of the hepatocyte microcapsule, and the side wall of the guide column 42 is provided with a plurality of flow guide through holes; the flow guide through holes are arranged adjacent to the sieve tray 41, and the two guide columns 42 are arranged oppositely.

In the practical application of the invention, the cell reactor is firstly connected into the biological artificial liver supporting system through the plasma transferring port 2, at the moment, the plasma flows into the cylinder 1 through the first screen device 4 in the cylinder 1, the plasma continuously flows forwards to the second screen device 4 by contacting with the hepatocyte microcapsule, a part of the plasma flows out from the through-hole of the screen disc 41, the other part of the plasma enters the guide column 42 from the flexible screen at the top end of the guide column 42, after the forward flow is blocked, further flows out from the guide through holes of the guide column 42, and the plasma flowing out at the moment is discharged out from the guide through holes, radial impact is generated on the surface of the sieve tray 41 to form an eddy effect, accumulation of hepatocyte microcapsules on the inner surface of the sieve tray 41 can be effectively reduced, the blood filtration effect and the smoothness of plasma passing are improved, and damage of hepatocyte microcapsules caused by continuous pressure accumulation is reduced.

As shown in FIGS. 1-3, the middle of the cylinder 1 is provided with a loading port 23 for placing the hepatocyte microcapsules.

The loading port 23 is used for loading the hepatocyte microcapsules into the cylinder 1 and then sealing the same when the cell reactor is produced.

As shown in fig. 4-5, four flow guide through holes are formed in the same guide post 42, and the four flow guide through holes are symmetrically arranged around the axis of the guide post 42.

As shown in fig. 4-7, the screen tray 41 is a flexible material screen tray.

The hepatocyte microcapsules load 50% of the volume within cartridge 1. The two slurry conveying ports 2 are provided with quick connecting joints. The cylinder body 1 is externally coated with a heat-insulating layer. The heat insulating layer is a foaming heat insulating layer.

As shown in fig. 3, the length of the cylinder 1 is 3 times the inner diameter of the cylinder 1.

As shown in fig. 4-5, a barrier net for blocking the entry of the hepatocyte microcapsules is arranged on the surface of the flow guide through hole.

The present invention is not limited to the above preferred embodiments, and any modifications, equivalent substitutions, improvements, etc. within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A cell reactor for use in a biotype artificial liver support system, characterized by: comprises a cylinder body (1); the device is characterized in that the barrel body (1) is hollow and cylindrical, two ends of the barrel body (1) are respectively provided with a pulp conveying port (2), two ends of the interior of the barrel body (1) are respectively provided with a screen device (4), a plurality of hepatocyte microcapsules are arranged in the barrel body (1), and the hepatocyte microcapsules are arranged between the two screen devices (4); the screen device (4) comprises: a sieve tray (41) and a guide post (42); the diameter of the sieve tray (41) is equal to the inner diameter of the cylinder (1), the sieve tray (41) is fixedly connected with the inner wall of the cylinder (1) in a sealing manner, and a plurality of pulp passing through holes are formed in the sieve tray (41); the guide column (42) is hollow and cylindrical, one end of the guide column (42) is fixedly connected with the central position of the inner side of the sieve tray (41), the sieve tray (41) and the circular bottom surface of the guide column (42) are arranged in a sealing mode, the other end of the guide column (42) covers a flexible sieve mesh, the diameter of the mesh of the flexible sieve mesh is smaller than that of the hepatocyte microcapsule, and a plurality of flow guide through holes are formed in the side wall of the guide column (42); the flow guide through holes are arranged adjacent to the sieve tray (41), and the two guide columns (42) are arranged oppositely; four guide through holes are arranged on the same guide column (42), and the four guide through holes are symmetrically arranged by taking the axis of the guide column (42) as a center; and a barrier net for blocking the liver cell microcapsules from entering is arranged on the surface of the flow guide through hole.

2. A cell reactor for a bioartificial liver support system as defined in claim 1, wherein: the middle part of the cylinder body (1) is provided with a loading port (23) for placing the hepatocyte microcapsules.

3. A cell reactor for a bioartificial liver support system as defined in claim 1, wherein: the sieve tray (41) is a sieve tray made of flexible materials.

4. A cell reactor for a bioartificial liver support system as defined in claim 1, wherein: the hepatocyte microcapsules load 50% of the volume inside the cartridge (1).

5. A cell reactor for a bioartificial liver support system as defined in claim 1, wherein: and the two pulp conveying ports (2) are provided with quick connecting joints.

6. A cell reactor for a bioartificial liver support system as defined in claim 1, wherein: the cylinder body (1) is wrapped with a heat-insulating layer.

7. A cell reactor for a bioartificial liver support system as defined in claim 6, wherein: the heat-insulating layer is a foaming heat-insulating layer.

8. A cell reactor for a bioartificial liver support system as defined in claim 1, wherein: the length of the cylinder body (1) is 3 times of the inner diameter of the cylinder body (1).