CN110201280B

CN110201280B - Suction nozzle for an inhalation device and inhalation device

Info

Publication number: CN110201280B
Application number: CN201810167611.3A
Authority: CN
Inventors: 张江
Original assignee: Individual
Current assignee: Individual
Priority date: 2018-02-28
Filing date: 2018-02-28
Publication date: 2021-07-30
Anticipated expiration: 2038-02-28
Also published as: CN110201280A

Abstract

The invention discloses a suction nozzle for an inhalation drug delivery device and the inhalation drug delivery device. The suction nozzle includes that the oral cavity contains into portion and wind powder suction channel, and the oral cavity contains into the portion including wind powder suction mouth and peripheral wind suction mouth, and wind powder suction mouth and wind powder suction channel intercommunication provide the suction for the powder, and peripheral wind suction mouth sets up in the wind powder suction mouth outside and with outside air intercommunication in order to form the peripheral wind in the outside of wind powder suction mouth. The peripheral air suction opening of the suction nozzle is arranged to form peripheral air outside the air powder suction opening, so that when the medicine powder passes through the oral cavity, the peripheral air outside the main circulation channel of the medicine powder has a certain isolation effect on the medicine powder and the oral cavity wall, the medicine powder is difficult to adhere to the oral cavity wall, and the proportion of the medicine powder entering the lung for administration is improved.

Description

Suction nozzle for an inhalation device and inhalation device

Technical Field

The invention relates to the technical field of medical appliances, in particular to a suction nozzle for an inhalation drug delivery device and the inhalation drug delivery device.

Background

Chronic obstructive pulmonary disease (chronic obstructive pulmonary disease) is a chronic lung disease characterized by airflow limitation that is not fully reversible. The world health organization estimates that chronic obstructive pulmonary disease is the third cause of death in our country, second only to tumors and cerebrovascular diseases.

The pulmonary inhalation is the first choice therapy of chronic obstructive pulmonary disease, and has the characteristics of targeting, high efficiency, quick acting, small toxic and side effects and the like. Common formulations for administration by inhalation include solution nebulization, metered dose nebulization and dry powder nebulization. Compared with solution atomization and metering atomization, the dry powder aerosol has good inhalation administration compliance, and is particularly suitable for patients with chronic obstructive pulmonary disease.

The mouthpiece of the prior art inhalation drug delivery device sucks the drug powder, and a part of the drug powder adheres to the oral cavity, thereby reducing the proportion of the drug powder that enters the lung and can actually exert the drug effect.

Disclosure of Invention

An object of the present invention is to provide a mouthpiece for an inhalation drug delivery device and an inhalation drug delivery device to reduce adhesion of a medicinal powder in an oral cavity.

The present invention provides, in a first aspect, a mouthpiece for an inhalation drug delivery device, the mouthpiece comprising an oral cavity intake portion and a powder suction passage, the oral cavity intake portion comprising an air-powder suction port and a peripheral air suction port, the air-powder suction port communicating with the air-powder suction passage to provide a suction force for a drug powder, the peripheral air suction port being provided on one side of the air-powder suction port and communicating with outside air to form peripheral air outside the air-powder suction port to isolate the drug powder from a wall of the oral cavity.

Further, the mouth containing section includes at least two of the peripheral air suction ports at different positions in the circumferential direction of the air-powder suction port.

Further, the oral cavity containing part comprises a suction end face positioned on one side of the oral cavity during suction, and the wind powder suction port and the peripheral wind suction port are arranged on the suction end face.

Further, the suction end face includes a curved surface that protrudes to the side away from the oral cavity.

Further, the curved surface is an arc-shaped cylindrical surface.

Further, the suction nozzle also comprises a rotational flow structure arranged on the air powder suction channel; and/or the suction nozzle also comprises a rectifying structure arranged on the air powder suction channel.

Further, the cyclone structure comprises cyclone blades arranged in the wind powder suction channel, and the cyclone blades are fixedly arranged relative to the wind powder suction channel.

Further, the end part of the cyclone blade is connected with the inner wall of the wind powder suction channel.

Further, the swirling structure is arranged at the downstream of the rectifying structure.

A second aspect of the invention provides an inhalation delivery device comprising a mouthpiece for an inhalation delivery device as provided in any of the first aspects of the invention.

Further, the inhalation drug delivery device further comprises a shell, the shell comprises a vent for introducing outside air, a drug box placing cavity for placing a drug box and a gas containing space, the drug box placing cavity and the gas containing space are communicated with the vent, the wind and powder suction port is communicated with the drug box placing cavity for sucking the medicine powder, and the peripheral wind suction port is communicated with the gas containing space for communicating with the outside air.

According to the suction nozzle for the inhalation drug delivery device and the inhalation drug delivery device provided by the invention, the suction nozzle comprises the oral cavity containing part and the air powder suction channel, the oral cavity containing part comprises the air powder suction port and the peripheral air suction port, the air powder suction port is communicated with the air powder suction channel to provide suction force for the medicine powder, and the peripheral air suction port is arranged on one side of the air powder suction port and is communicated with the external air to form peripheral air on the outer side of the air powder suction channel. The peripheral air suction opening of the suction nozzle is arranged to form peripheral air outside the air powder suction opening to isolate the medicinal powder from the oral cavity wall, so that when the medicinal powder passes through the oral cavity, the peripheral air outside the main circulation channel of the medicinal powder has a certain isolation effect on the medicinal powder, the medicinal powder is difficult to adhere to the oral cavity wall, and the proportion of the medicinal powder entering the lung for administration is improved.

Other features of the present invention and advantages thereof will become apparent from the following detailed description of exemplary embodiments thereof, which proceeds with reference to the accompanying drawings.

Drawings

The accompanying drawings, which are included to provide a further understanding of the invention and are incorporated in and constitute a part of this application, illustrate embodiment(s) of the invention and together with the description serve to explain the invention without limiting the invention. In the drawings:

FIG. 1 is a schematic perspective view of an angle of an inhalation delivery assembly according to an embodiment of the present invention;

FIG. 2 is a schematic perspective view of another angle of an inhalation delivery assembly according to an embodiment of the present invention;

FIG. 3 is an exploded view of the inhalation delivery assembly shown in FIG. 1;

FIG. 4 is a schematic structural view of the cartridge of FIG. 3;

fig. 5 is a schematic view of an angle of the first and second receiving division bodies of fig. 3;

fig. 6 is a structural view of another angle of the first and second receiving division bodies of fig. 3;

FIG. 7 is a schematic structural view of each first swirling structure of FIG. 3;

FIG. 8 is a schematic view of a first swirling structure of FIG. 3;

FIG. 9 is a schematic structural view of the turntable in FIG. 3;

FIG. 10 is a schematic view of another angular configuration of the turntable shown in FIG. 9;

FIG. 11 is a schematic structural view of the elastic member of FIG. 3;

FIG. 12 is a schematic view of the detent disc of FIG. 3;

FIG. 13 is a schematic structural view of the mounting plate of FIG. 3;

FIG. 14 is a schematic structural view of the retainer plate of FIG. 3;

FIG. 15 is a schematic structural view of the outer ring of the turntable in FIG. 3;

FIG. 16 is a schematic structural view of the marker disk of FIG. 3;

FIG. 17 is a schematic structural view of the first housing of FIG. 3;

FIG. 18 is a schematic structural view of the second housing of FIG. 3;

FIG. 19 is a schematic view of the trachea of FIG. 3;

FIG. 20 is a schematic view of the nozzle of FIG. 3 in one orientation;

figure 21 is a schematic view of the suction nozzle of figure 3 in another orientation.

Each reference numeral represents:

1-a first housing; 1A-vent; 2-a second housing; 2A-the opening of the first medicine box placing cavity; 3-a box body; 3A-an air inlet; 3B-air powder outlet; 31-inner ring wall of the box body; 32-outer ring wall of the box body; 33-a first end wall; 33A-vias; 34-a second end wall; 4-a first containing split body; 5-a first swirl structure; 6-a second containing split body; 61-receptacle ratchet; 6A-a rotating shaft; 7-mounting a disc; 71-a connecting strip; 8-a logo disc; 9-a ratchet plate; 91-pawl plate pawl; 92-connecting projections; 10-outer ring of the turntable; 10A-window; 11-a limiting disc; 11A-a limit groove; 11B-a second connecting groove; 12-a resilient element; 13-a turntable; 13A-first connecting groove; 131-a turntable pawl; 132-a limit projection; 15-trachea; 151-a rectifying structure; 16-a suction nozzle; 16A-wind powder suction port; 16B-peripheral air suction ports; 17-a gas tube connection; 18-a mouthpiece cover; 19-second swirl structure.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. The following description of at least one exemplary embodiment is merely illustrative in nature and is in no way intended to limit the invention, its application, or uses. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

The relative arrangement of the components and steps, the numerical expressions and numerical values set forth in these embodiments do not limit the scope of the present invention unless specifically stated otherwise. Meanwhile, it should be understood that the sizes of the respective portions shown in the drawings are not drawn in an actual proportional relationship for the convenience of description. Techniques, methods, and apparatus known to those of ordinary skill in the relevant art may not be discussed in detail but are intended to be part of the specification where appropriate. In all examples shown and discussed herein, any particular value should be construed as merely illustrative, and not limiting. Thus, other examples of the exemplary embodiments may have different values. It should be noted that: like reference numbers and letters refer to like items in the following figures, and thus, once an item is defined in one figure, further discussion thereof is not required in subsequent figures.

Spatially relative terms, such as "above … …," "above … …," "above … …," "above," and the like, may be used herein for ease of description to describe one device or feature's spatial relationship to another device or feature as illustrated in the figures. It will be understood that the spatially relative terms are intended to encompass different orientations of the device in use or operation in addition to the orientation depicted in the figures. For example, if a device in the figures is turned over, devices described as "above" or "on" other devices or configurations would then be oriented "below" or "under" the other devices or configurations. Thus, the exemplary term "above … …" can include both an orientation of "above … …" and "below … …". The device may be otherwise variously oriented (rotated 90 degrees or at other orientations) and the spatially relative descriptors used herein interpreted accordingly.

A mouthpiece for an inhalation delivery device of an embodiment of the present invention includes a mouth intake portion and a wind powder suction passage. The oral cavity containing part comprises an air powder suction port and a peripheral air suction port, the air powder suction port is communicated with the air powder suction channel to provide suction force for the medicinal powder, and the peripheral air suction port is arranged on one side of the air powder suction port and communicated with external air to form peripheral air on the outer side of the air powder suction port to isolate the medicinal powder from the oral cavity wall. The peripheral air suction opening of the suction nozzle of the embodiment of the invention enables the peripheral air to be formed outside the air powder suction opening, so when the medicine powder passes through the oral cavity, the peripheral air outside the main circulation channel of the medicine powder has a certain isolation effect on the medicine powder and the oral cavity wall, the medicine powder is difficult to adhere to the oral cavity wall, and the proportion of the medicine powder entering the lung for administration is improved.

Preferably, the mouth-containing section includes at least two peripheral air suction ports located at different positions in the circumferential direction of the air-powder suction port. So set up the air-out point that can increase the wind of periphery, prevent on the powder adhesion mouth cavity wall better.

The structure of a mouthpiece and the structure of an inhalation drug delivery device having the mouthpiece according to an embodiment of the present invention will be described in detail with reference to fig. 1 to 21.

As shown in fig. 20 and 21, the mouthpiece 16 of the present embodiment includes an oral cavity intake portion 162. The mouth inlet portion 162 is provided with a wind powder suction port 16A to provide suction force for the inhalation of the drug powder. When the patient uses the inhalation/drug delivery combination structure of this embodiment, the drug powder can be sucked into the body by holding the mouth containing portion 162 in the inlet and forcibly inhaling.

Since the mouthpiece 16 needs to be in direct contact with the mouth of the patient, in order to prevent contamination of the mouthpiece 16, the inhalation drug delivery device of the present embodiment further includes a mouthpiece cover 18 disposed outside the mouthpiece 16.

Preferably, the mouth containing part 162 of the present embodiment further has a peripheral wind suction port 16B provided at a side of the wind powder suction port 16A and communicating with the outside air to form a peripheral wind outside the wind powder suction port 16A. The peripheral air suction port 16B is arranged to form peripheral air outside the air powder suction port 16A, so that when the medicinal powder passes through the oral cavity, the peripheral air outside the main flow passage of the medicinal powder has a certain isolation effect on the medicinal powder, so that the medicinal powder is difficult to adhere to the wall of the oral cavity, and the proportion of the medicinal powder entering the lung for administration is increased.

The inhalation delivery device of the present embodiment comprises a mouthpiece and a housing for mounting the mouthpiece and a medicine cartridge. As shown in fig. 21, the suction nozzle 16 is mounted on the housing through a nozzle body 161.

The housing includes a vent for introducing external air, a cartridge placing chamber for placing the cartridge, and a gas containing space. The medicine box placing cavity and the gas containing space are communicated with the vent hole, the air and powder suction port 16A and the medicine box placing cavity are communicated with each other to suck medicine powder, and the peripheral air suction port 16B is communicated with the gas containing space to be communicated with the external air.

Specifically in the present embodiment, as shown in fig. 1, 2, 17, and 18, the housing includes a first housing 1 and a second housing 2. The first casing 1 is provided with a vent 1A for introducing outside air. The second housing 2 has a cartridge placing chamber. The cartridge placing chamber has a first cartridge placing chamber opening 2A communicating with the vent 1A. The cartridge housing chamber of this embodiment also has a second cartridge housing chamber opening communicating with the air-powder suction port 16A.

A gas containing space is formed between the first casing 1 and the second casing 2. The gas entering the first housing 1 through the vent 1A of the first housing 1 partially enters the cartridge through the first cartridge placing chamber opening on the second housing, and partially enters the gas accommodating space formed between the first housing 1 and the second housing 2. The suction nozzle 16 is provided on the housing. And the air and powder suction port 16A of the suction nozzle 16 communicates with the second medicine box placing chamber opening on the second casing through the air and powder suction passage to suck the medicine powder. A peripheral wind suction port 16B of the suction nozzle 16 on one side of the wind powder suction port communicates with the gas containing space to communicate with the outside air to form a peripheral wind.

Preferably, in order to filter the air entering the housing, as shown in fig. 17, the first housing 1 of the present embodiment is provided with a filter structure at the vent 1A. And the first medicine box placing cavity opening 2A of the second shell of the embodiment is provided with a flow equalizing structure.

Specifically, as shown in fig. 17 and 18, the filter structure of the first casing 1 is provided with a support portion 1B extending toward the inside of the first casing 1. When the second housing 2 is fastened to the first housing 1, the support portion 1B provides a gap between the second housing 2 and the first housing 1, so that a gas accommodating space is formed between the outer side surface of the medicine box accommodating chamber of the second housing 2 and the first housing 1. When the suction nozzle 16 is mounted on the housing, the peripheral wind suction port of the suction nozzle 16 can suck the gas in the gas containing space to form peripheral wind.

Preferably, the mouth containing portion 162 is provided with at least two peripheral air suction ports 16B located at different positions in the circumferential direction of the air powder suction port 16A. So set up the air-out point that can increase the wind of periphery, prevent on the powder adhesion mouth cavity wall better.

In order to equalize the peripheral air outside the air and powder suction opening 16A and prevent the powder from greatly deviating in the flowing direction of the powder entering the inlet cavity, two peripheral air suction openings 16B are symmetrically arranged on two sides of the air and powder suction opening 16A of the present embodiment.

In an embodiment not shown in the drawings, at least two peripheral air suction openings may also be provided around the air dust suction opening. So set up and all form week wind in the week of making wind powder suction channel, prevent powder adhesion on the oral cavity wall more all-roundly.

The mouth inlet 162 includes a suction end surface located on one side of the mouth when suctioning. The wind powder suction port 16A and the peripheral wind suction port 16B are both provided on the suction end face.

Preferably, the suction end face of the present embodiment includes a curved surface that protrudes to the side away from the oral cavity. The curved surface forms a concave space so as to facilitate the oral cavity containing part to effectively fit the oral lip to prevent the oral cavity from being exposed and avoid the tongue as much as possible, thereby preventing the medicinal powder from being adhered to the oral cavity and the tongue.

Specifically, in this embodiment, the curved surface is an arc-shaped cylindrical surface.

In order to prevent the flow direction of the powder entering the oral cavity from the air powder suction passage from deviating, the oral cavity containing part of the embodiment includes two peripheral air suction ports located at both ends of the air powder suction port, and the centers of the two peripheral air suction ports and the center of the air powder suction port are located on the same straight line parallel to the generatrix of the arc-shaped cylindrical surface.

The suction nozzle of this embodiment includes that the oral cavity contains the portion of inserting, and the oral cavity contains the peripheral wind suction mouth that sets up in the portion and makes and form peripheral wind in the outside of wind powder suction mouth, and consequently powder is when passing through the oral cavity, and the peripheral wind in the outside of the circulation main channel of powder forms certain isolation effect to between powder and the oral cavity wall, makes the difficult adhesion of powder on the oral cavity wall, consequently improves the proportion of the powder that gets into the lung and administrate.

The inhalation administration combination structure comprises an inhalation administration device and a medicine box. To better explain the structure and operation of the inhalation device, the structure of the cartridge of this embodiment will be described.

As shown in fig. 1 to 8, the medicine cartridge of the present embodiment includes a cartridge body 3 and a medicine powder containing body. The medicine powder containing body is arranged in the box body 3 and is provided with a medicine powder containing cavity for containing medicine powder. The powder containing chamber includes a first opening of the powder containing chamber and a second opening of the powder containing chamber. The box body 3 is provided with an air inlet 3A for introducing external air into the box body 3 and an air-powder outlet 3B for outputting an air-powder mixture. The medicine powder containing body is movably disposed with respect to the case body 3 to switch the medicine powder containing chamber between a closed state and an open state. In the closed state, the case body 3 closes the first opening of the powder containing chamber and the second opening of the powder containing chamber. In the open state, the first opening of the powder holding chamber communicates with the air inlet 3A, and the second opening of the powder holding chamber communicates with the air powder outlet 3B so that the powder can be sucked out from the air powder outlet together with the outside air introduced into the air inlet under the suction force of the air powder outlet.

In the present embodiment, the medicine powder containing body is rotatably provided with respect to the case body 3 so that the medicine powder containing chamber is switched between the closed state and the open state. The powder container can be rotationally arranged relative to the box body in the embodiment, so that the volume of the medicine box is small, and the medicine box is favorable for storage and carrying. The powder holding chamber may be arranged, for example, radially, axially, at an angle to the radial direction, at an angle to the axial direction, or the like.

In the present embodiment, specifically, the medicine powder containing body is coaxially and rotatably provided with respect to the case body 3. as shown in fig. 4, the case body 3 comprises an annular case body. The annular box body comprises a first box body annular wall, a second box body annular wall and an installation space formed between the first box body annular wall and the second box body annular wall. The air inlet 3A is arranged on the annular wall of the first box body, and the air powder outlet 3B is arranged on the annular wall of the second box body. The medicine powder containing body is arranged in the installation space. The powder container has a first container circumferential wall and a second container circumferential wall. The powder holds the chamber and is located first and hold between the body rampart and the second and hold between the body rampart, and the powder holds the first opening in chamber and sets up on the first body rampart that holds, and the powder holds the second opening in chamber and sets up on the second body rampart that holds. The medicine box of this embodiment sets up box body 3 to annular box body and holds the body with the powder and set up in the installation space between first box body rampart and the second box body rampart and make the compact structure of medicine box of this embodiment.

In this embodiment, the first box body annular wall is a box body annular wall 31 located at the radial inner side of the annular box body. The second box body annular wall is a box body outer annular wall 32 located at the radial outer side of the annular box body. In other embodiments, the first cassette annular wall may be located radially outwardly of the annular cassette and the second cassette annular wall may be located radially inwardly of the annular cassette.

Preferably, the air inlet 3A and the air powder outlet 3B are provided in the same direction in the radial direction of the case 3. The powder containing chamber extends in a radial direction of the powder containing body. When a patient needs to suck the medicine powder, the medicine powder containing body is controlled to rotate relative to the box body 3 so as to communicate the medicine powder containing cavity with the air inlet and the air powder outlet. When the patient does not need to suck the medicine powder, the medicine powder containing body is controlled to rotate relative to the medicine powder containing chamber to a position closed by the medicine powder containing chamber 3.

As shown in fig. 4, in this embodiment, the annular case further includes a first end wall 33 disposed on the inner annular wall 31 of the case, the powder holding body is rotatably connected to the first end wall 33, and the first end wall 33 and the inner annular wall 31 of the case form an air inlet chamber communicating with the air inlet 3A. The arrangement of the air inlet cavity enables a space to exist between the external space of the inhalation drug delivery combined structure and the air inlet 3A, and the arrangement of accessories such as a filtering structure and a flow equalizing structure is facilitated.

In particular, the annular box comprises a second end wall 34 disposed between the box inner annular wall 31 and the box outer annular wall 32. The box body inner annular wall 31, the box body outer annular wall 32 and the second end wall 34 enclose an annular groove, and the annular groove forms an installation space. The second end wall 34 and the first end wall 33 are disposed at both axial ends of the box body 3.

In an embodiment not shown in the drawings, the powder containing body may also be arranged translatably in relation to the cartridge. For example, the powder containing body and the cartridge are each a cubic structure, and the powder containing body is disposed in the cartridge and translatably disposed along the length direction of the cartridge.

In the present embodiment, as shown in fig. 5 and 6, the medicine powder containing body includes a first containing division body 4 and a second containing division body 6. The first sub-chamber that holds is equipped with on the first components of a whole that can function independently 4 that holds, the second holds and is equipped with the second on the components of a whole that can function independently 6 and holds the sub-chamber. The first branch chamber that holds 4 and the second of the components of a whole that can function independently 6 locks messenger corresponding position holds with the second and holds the branch chamber and form powder jointly and hold the chamber. The powder of this embodiment holds the body components of a whole that can function independently and sets up the components of a whole that can function independently that holds that two mutual locks make things convenient for the powder to hold the partial shipment of the powder in chamber.

The powder holding chamber of this embodiment is a cylindrical chamber structure, and in other embodiments not shown in the drawings, the powder holding chamber may be configured in other shapes, such as a cubic structure.

Preferably, in order to make the fastening between the first accommodating split body 4 and the second accommodating split body 6 more firm, one of the first accommodating split body 4 and the second accommodating split body 6 is provided with a connecting column, and the other is provided with a connecting hole, and the connecting column is inserted into the connecting hole so that the first accommodating split body 4 and the second accommodating split body 6 are fastened tightly with each other.

Specifically, in this embodiment, as shown in fig. 5 and 6, the first accommodating split body 4 is provided with both a connection column and a connection hole, and correspondingly, the second accommodating split body 6 is provided with both a connection column that is matched with the connection hole provided in the first accommodating split body 4 and a connection hole that is matched with the connection column provided in the first accommodating split body 4. The arrangement is such that the fitting between the first and second

accommodation division bodies

4 and 6 is tighter.

Furthermore, the connecting column of the embodiment is of a circular structure, and the connecting hole is of a square structure. The arrangement facilitates the combination of the medicine powder containing body.

Specifically, the first accommodation component 4 of the present embodiment is of an annular structure and is sleeved outside the box inner wall 31 of the box body 3. The second accommodation division body 6 is engaged with the first accommodation division body 4 and is disposed on the first end wall 33. As shown in fig. 4, the first end wall 33 is provided with a through hole 33A. The second holds and is provided with axis of rotation 6A on the components of a whole that can function independently 6, and axis of rotation 6A wears to locate in through-hole 33A so that the second holds the components of a whole that can function independently 6 rotatable for box body 3, because the first body of a whole that can function independently 4 holds with the second holds components of a whole that can function independently 6 interconnect, therefore the second holds the components of a whole that can function independently 6 and rotates and can drive the first body of a whole that can function independently 4 synchronous revolution for box body 3.

Preferably, the powder containing body of this embodiment includes two or more powder containing chambers. More than two powder of medicine box of this embodiment hold the chamber and can hold many doses of powder, and the patient can rotate so that more than two powder hold the chamber and be in open state and then aspirate the powder in different powder hold chamber in proper order through control powder holding body relative to box body 3 when using the medicine box of this embodiment to inhale and dose. At the moment, more than two medicine powder containing cavities can be used for containing different kinds of medicine powder and can also be used for containing the same kind of medicine powder. For example, when the same kind of powder is placed in two or more powder-containing chambers, the patient can sequentially suck the powder in the different powder-containing chambers according to the amount of the powder to be used for dosing. When different kinds of medicinal powder are placed in more than two medicinal powder containing cavities, the patient can suck according to the dosage of different medicinal powder. The kit of this embodiment is therefore convenient for the patient to administer.

Fig. 5 and 6 schematically show that the powder containing body of the medicine cartridge has seven powder containing chambers, and the powder containing body is rotatably provided with respect to the case body 3 such that the seven powder containing chambers are sequentially communicated with the air inlet port 3A and the air outlet port 3B.

Preferably, as shown in fig. 3, 7 and 8, the medicine cartridge of the present embodiment further comprises a first swirling structure 5 provided upstream of the first opening of the powder containing chamber and for causing the air flow to swirl before blowing the powder. The first cyclone structure 5 is provided upstream of the first opening of the powder-holding chamber so that the air current generates a cyclone flow before blowing the powder to increase the amount of powder sucked to the lung, thereby increasing the proportion of powder sucked to the lung.

As shown in fig. 7, the medicine cartridge of the present embodiment includes two or more first cyclone structures 5 provided corresponding to the two or more medicine powder containing chambers. For ease of assembly, more than two first swirl structures 5 may be connected together.

As shown in fig. 8, the first swirling structure 5 of the present embodiment has an air flow inlet end, an air flow outlet end, and a swirling flow passage provided between the air flow inlet end and the air flow outlet end. The swirl passage comprises more than two swirl parts which are sequentially arranged from the radial inner side of the flow passage to the radial outer side of the flow passage in a surrounding manner, and each swirl part is used for generating swirl on part of airflow input into the swirl part and then outputting the swirl part. The first swirling structure 5 of the present embodiment is configured with more than two swirling portions arranged in a surrounding manner in the swirling channel, so that the airflows at different positions of the swirling channel from the radial inner side of the flow channel to the radial outer side of the flow channel can generate swirling flows, and therefore the airflows at different positions in the whole flow channel can generate swirling flows, and the suction amount of the powder is increased.

Specifically, as shown in fig. 8, the first swirling structure 5 of the present embodiment includes a first swirling portion 51 and a second swirling portion 52. The first swirling flow portion 51 and the second swirling flow portion 52 generate swirling flows in opposite directions. The medicine box of this embodiment sets up the direction of the whirl that adjacent whirl portion produced to reverse for airflow before blowing powder forms the whirl of different directions, thereby also is different to the direction of the impact force of powder, consequently can be better with powder atomization for less powder, change easily by the patient absorption.

In the present embodiment, the first swirling structure 5 is provided at the air inlet 3A. In order to facilitate the guarantee of the sealing property of the medicine powder containing cavity and make the air flow entering the medicine powder containing cavity more concentrated, the end face of the air flow inlet end of the first rotational flow structure 5 is in contact with and matched with the end face of the air inlet of the medicine box in shape. The first cyclone structure 5 of this embodiment is disposed at the air inlet 3A of the case 3, the end face of the air inlet end of the first cyclone structure 5 is in contact fit with the case 3, and the end face of the air outlet end of the first cyclone structure 5 is in contact fit with the powder containing body.

In this embodiment, the first box body annular wall of the box body 3 is a cylindrical structure, so as shown in fig. 8, the end surface of the airflow inlet end of the first rotational flow structure 5 is set to be a cylindrical arc structure protruding to the airflow outlet end side.

Preferably, the first swirling structure 5 further includes an outer guide surface provided outside the first swirling portion from the outside of the flow passage. The outer guide surface is an expanding surface gradually enlarged from the upstream to the downstream of the swirl passage at least on one side of the airflow outlet end. Outside water conservancy diversion face sets up to the expansion face and does benefit to and makes the air current strike the powder that is located the chamber wall department that powder held the chamber to reduce powder and remain, increase the powder volume that gets into in the patient oral cavity.

In particular, in this embodiment, the flared surface includes a conical surface configuration.

Preferably, in order to avoid the mutual influence of the airflows between two adjacent swirling portions, as shown in fig. 8, an isolation structure 52 for isolating the airflows of the two swirling portions is provided between the adjacent swirling portions of the present embodiment.

Preferably, the separating structure 52 includes a first intermediate flow guide surface for guiding the airflow of the inner one of the two swirling portions separated therefrom and a second intermediate flow guide surface for guiding the airflow of the outer one of the two swirling portions separated therefrom.

Specifically, the first intermediate flow guide surface is an expansion surface whose sectional area gradually increases from the upstream to the downstream of the swirling flow channel at least on the side of the air flow outlet end, and the second intermediate flow guide surface is an expansion surface whose sectional area gradually increases from the upstream to the downstream of the swirling flow channel at least on the side of the air flow outlet end. The arrangement of the expansion surface can also enable the airflow to impact the medicine powder on the cavity wall of the medicine powder containing cavity, so that the medicine powder amount entering the oral cavity of the patient is increased.

The medicine cartridge of the present embodiment includes a cartridge body 3 and a medicine powder containing body. The powder containing body has two or more powder containing chambers and is rotatably provided with respect to the cartridge body 3. And a first rotational flow structure 5 is arranged at the air inlet 3A of the box body 3. The patient can rotate relative to the box body through controlling the powder container when using the medicine box of this embodiment in order to aspirate the powder in different powder container chambers, therefore the medicine box of this embodiment makes things convenient for the patient to use medicine. In addition, the medicine box of the embodiment enables the airflow to generate rotational flow before the medicine powder is blown by arranging the first rotational flow structure at the air inlet so as to fully atomize the medicine powder, thereby increasing the proportion of the medicine powder inhaled into the lung.

Preferably, in order to better atomize the powder, as shown in fig. 20 and 21, the inhalation delivery device of the present embodiment further includes a second cyclone structure 19 provided on the air-powder suction passage. Second whirl structure 19 makes the wind powder mixture of wind powder export produce the whirl and then further atomize when passing through wind powder suction channel to improve the atomization effect of powder, further improve the absorption rate of patient to powder.

The inhalation administration combination structure of the present embodiment atomizes the powder sufficiently to improve the absorption rate of the powder by providing the first cyclone structure 5 for generating a cyclone to the air flow before the powder is impacted and the second cyclone structure 19 for generating a cyclone to the air-powder mixture.

The second swirling structure 19 includes a swirling passage and swirling vanes provided in the swirling passage.

Specifically, the swirl vanes are fixedly disposed relative to the swirl passage. The arrangement is favorable for maintaining the stability of the amount of the medicinal powder inhaled each time.

The suction nozzle 16 of the present embodiment further includes an air tube 15 provided between the nozzle body 161 and the housing. The air tube 15 is connected to the housing by an air tube connection 17. The inner cavity of the air tube 15 forms part of the air and powder suction passage.

Preferably, a rectifying structure 151 for rectifying the wind-powder mixture is arranged in the air pipe 15.

In the present embodiment, the second swirling structure 19 is disposed downstream of the rectifying structure 151, that is, the rectifying structure 151 is disposed between the first swirling structure 5 and the second swirling structure 19. Thus, the air flow generates rotational flow before the medicine powder is blown and then is mixed with the medicine powder to form the air-powder mixture. Carry out the rectification earlier through rectification structure 151 after forming wind powder mixture and make wind powder mixture steady flow in whole wind powder suction channel, then rethread second whirl structure 19 carries out the whirl to the wind powder mixture in whole wind powder suction channel, can make more wind powder mixtures carry out the whirl, makes the powder fully atomize.

Preferably, in order to accelerate the powder blown out from the medicine cartridge, the inhalation delivery device of the present embodiment further comprises an air-powder acceleration channel disposed between the first and

second swirling structures

5 and 19. The air-powder accelerating channel enables the medicinal powder to be sufficiently accelerated under the driving of the air flow, so that the medicinal powder enters the second rotational flow structure at a high speed to be sufficiently atomized by effectively scattering the medicinal powder.

Specifically, in the present embodiment, the wind powder accelerating passage is an accelerating cavity disposed between the first swirling structure 5 and the second swirling structure 19. The acceleration chamber provides a space for acceleration of the powder, so that the powder can have a faster speed when entering the second cyclone structure.

Preferably, the length of the acceleration chamber is greater than or equal to 10 mm.

More preferably, the length of the acceleration chamber is greater than 20 mm.

In order to improve the convenience of the patient in using the inhalation delivery combined structure of the present embodiment, the inhalation delivery device of the present embodiment includes a driving mechanism for driving the movement of the drug powder containing body relative to the case body 3.

In this embodiment, the drive mechanism comprises a ratchet disc 9 which is rotatable relative to the cassette 3. The ratchet disc 9 is provided with ratchet disc pawls 91. The medicine powder containing body is provided with a containing body ratchet. The ratchet disc pawls 91 drive the containing body ratchet to rotate to drive the powder containing body to rotate.

Specifically, as shown in fig. 5, the second containing division 6 of the medicine powder containing body is provided with a containing body ratchet 61 on the top surface thereof. The ratchet plate 9 on which the ratchet plate pawls 91 are mounted is mounted on the mounting plate 7 and cooperates with the containing body ratchet provided on the medicine powder containing body to drive the second containing division 6 to rotate. The second accommodation division body 6 is connected to the first accommodation division body 4, so that the first accommodation division body 4 can also be rotated in synchronization with the second accommodation division body 6 to thereby achieve rotation of the medicine powder accommodation body.

As shown in fig. 13, the mounting plate 7 is provided with a plurality of connection bars 71 arranged at intervals in the circumferential direction. The ratchet disc 9 is provided with a plurality of coupling projections 92. The connecting strip 71 is snapped between the two connecting projections 92 to mount the ratchet disc on the mounting plate 7.

For convenience of operation, as shown in fig. 9, the inhalation-drug delivery combination structure in the present embodiment further includes a dial 13 provided with a knob. Ratchet disc 9 is connected to rotary disc 13 for synchronous rotation by rotary disc 13.

Turntable 13 is provided with a turntable pawl 131. Of course, in an embodiment not shown in the drawings, the drug powder container may be driven to rotate by directly engaging the ratchet of the dial with the ratchet of the container.

In order to facilitate obtaining the usage information of the medicine cartridge of the present embodiment, the inhalation drug delivery device of the present embodiment further includes an information display structure for displaying the usage information of the medicine cartridge.

The medicine powder containing body comprises more than two medicine powder containing cavities. The information display structure comprises more than two marker discs 8 with more than two marks corresponding to the more than two medicine powder containing cavities. The marker disk 8 rotates in synchronism with the powder containing body. As shown in fig. 15 and 16, the inhalation-administration combination structure of the present embodiment includes a dial 8 and a dial outer 10. The turntable outer ring 10 is fixedly arranged relative to the case 3. The turntable outer ring 10 is provided with a window 10A. The marker disk 8 is arranged below the turntable outer ring 10. The window 10A may display the logo on the logo plate 8 during rotation of the logo plate 8. Also, as shown in fig. 1, the turntable 13 is disposed at the middle of the turntable outer ring 10, and an arrow is disposed on the turntable outer ring 10 to show the direction of rotation of the turntable 13.

Specifically, in this embodiment, as shown in fig. 16, the marker plate 8 is provided with counting marks corresponding to two or more powder holding chambers. The dial 8 is rotated synchronously with respect to the powder medicine accommodating body to display the use condition of the powder medicines in the plural powder medicine accommodating chambers in the powder medicine accommodating body. For example, with the medicine cartridge of the present embodiment, there are seven medicine powder containing chambers. When the cartridge of this embodiment is not in use, the dial 8 count flag is displayed as zero. The counting marks of the marking disk 8 become larger gradually as the medicine powder in the medicine powder containing cavity in the medicine box is used gradually. When the counting mark on the marking disc 8 reaches seven, the patient can know that the medicine powder in the medicine box is completely used up, and the medicine box can be replaced by a new medicine box for use. The provision of the marker disk 8 makes the inhalation administration combination of the present embodiment more convenient to use.

In other embodiments, the mark on the marking plate may further include information on the use of the medicine cartridge, such as information on the kind of the medicine powder. For example, when two or more powder medicine-containing chambers contain different kinds of powder medicine, the marker on the marker plate may be powder medicine kind information corresponding to the kinds of powder medicine in the powder medicine-containing chambers.

In order to rotate the dial 8 in synchronization with the powder container, as shown in fig. 16, a dial ratchet is provided on the inner edge of the dial 8. The turntable pawls 131 cooperate with the marker disc ratchets to drive the marker disc ratchets to rotate, and at the same time, the turntable drives the pawl disc 9 to rotate synchronously, thereby making the marker disc 8 and the medicine powder containing body rotate synchronously, so that the counting marks on the marker disc 8 can show the use state of the medicine powder containing cavity of the medicine powder containing body.

Preferably, as shown in fig. 11, the inhalation-delivery combination structure further comprises an elastic member 12 for automatically returning the ratchet of the rotating disc, a first end of the elastic member 12 is fixedly disposed opposite to the rotating disc 13, and a second end of the elastic member is fixedly disposed opposite to the box body 3.

Specifically, as shown in fig. 10, the bottom of the rotating disk 13 is provided with a first coupling groove 13A, and a first end of the elastic member 12 is coupled in the first coupling groove 13A. The inhalation and administration combination structure of the embodiment further comprises a limiting disc 11 which is fixedly arranged relative to the box body 3. The limiting disc 11 is provided with a second connecting groove 11B. A second end of the elastic member 12 is coupled to the second coupling groove 11B. Because the first end of elastic element 12 is fixedly connected with carousel 13, the second end of elastic element 12 is fixedly connected with spacing dish 11, consequently can be automatic the return under the pulling of elastic element 12 after carousel 13 rotates under patient's rotation.

In the present embodiment, the elastic member 12 is a torsion spring.

Preferably, in order to control the rotation range of the ratchet 131 of the rotary disc so that the plurality of powder containing cavities are sequentially communicated with the air powder outlet on the box body 3, and thus sequential administration of the powder in the plurality of powder containing cavities by the patient is realized, as shown in fig. 14, a limiting groove 11A is provided on the limiting disc 11 of this embodiment. As shown in fig. 10, the rotary plate 13 is provided with a limit protrusion 132. The limit projection 132 swings in the limit groove 11A to limit the range of rotation of the turntable pawl 131 at a time.

More preferably, in order to ensure the reliability of the limit of the turntable pawl 131, the limit disk of the present embodiment is provided with two limit grooves which are symmetrically arranged. The two limit grooves are respectively matched with the limit bulges on the rotating disc 13.

The driving mechanism of the embodiment realizes the display of the use state of the medicinal powder containing body by the marking disc 8 by arranging the rotary disc 13 and the pawl disc 9 which synchronously rotates with the rotary disc 13, so that the rotary disc 13 drives the marking disc 8 to rotate while the rotary disc pawls on the rotary disc 13 drive the marking disc 8 to rotate. And the rotary disk 13 is provided with a knob, which is convenient for the operation of the patient.

The test results of the test personnel using the first preparation and the second preparation to respectively test the powder suction effect of the medicine box provided with the first rotational flow structure and the powder suction effect of the medicine box not provided with the first rotational flow structure are shown in table 1. The first preparation has a particle diameter of 10 μm. The second preparation has a particle diameter of 2.8 μm. As shown in the test data in table 1, for two reagents having different diameters of powder particles, the powder suction amount of the cartridge provided with the first cyclone structure is larger than that of the cartridge not provided with the first cyclone structure in the same loading amount. In summary, the first rotational flow structure can increase the amount of the powder sucked out of the medicine box.

Table 1: test result of medicine box with first rotational flow structure

The test personnel respectively tested the powder suction effect of the medicine boxes provided with the first and second cyclone structures and the powder suction effect of the medicine boxes provided with the first cyclone structure but not provided with the second cyclone structure by using the third and fourth preparations, and the test results are shown in table 2. In table 2, gmd (geometric Mean diameter) represents the geometric Mean diameter of the powder particles, and mmad (mass media Aerodynamic diameter) represents the mass Mean Aerodynamic diameter of the powder particles. Wherein the geometric mean diameter of the particles of the drug powder of the third preparation is 2.1 μm. The geometric mean diameter of the drug powder particles of the fourth preparation was 2 μm.

As shown in the test data in table 2, the mass mean aerodynamic diameter of the powder sucked out by the cartridge with the second swirling structure is smaller than that of the powder sucked out by the cartridge without the second swirling structure. And the proportion of the powder with the mass average aerodynamic diameter smaller than 3.4 mu m and smaller than 5 mu m in the powder sucked out by the medicine box provided with the second rotational flow structure is larger than the proportion of the corresponding mass average aerodynamic diameter in the powder sucked out by the medicine box not provided with the second rotational flow structure. In conclusion, the arrangement of the second rotational flow structure can fully atomize the medicinal powder, and is more beneficial to the absorption of patients.

In summary, the suction nozzle and the inhalation drug delivery device of the embodiments of the present invention have at least the following advantages:

the peripheral air suction opening of the suction nozzle of the embodiment of the invention enables the peripheral air to be formed outside the air powder suction opening, so when the medicine powder passes through the oral cavity, the peripheral air outside the main circulation channel of the medicine powder has a certain isolation effect on the medicine powder and the oral cavity wall, the medicine powder is difficult to adhere to the oral cavity wall, and the proportion of the medicine powder entering the lung for administration is improved.

Furthermore, the inhalation administration device provided by the embodiment of the invention is provided with the first rotational flow structure, so that the suction quantity of the medicinal powder can be improved. The second rotational flow structure is arranged to improve the atomization effect of the medicine powder, so that the medicine powder amount inhaled into the lung of a patient is improved.

Table 2: test result of medicine box provided with first rotational flow structure and second rotational flow structure

Finally, it should be noted that: the above examples are only intended to illustrate the technical solution of the present invention and not to limit it; although the present invention has been described in detail with reference to preferred embodiments, those skilled in the art will understand that: modifications to the specific embodiments of the invention or equivalent substitutions for parts of the technical features may be made; without departing from the spirit of the present invention, it is intended to cover all aspects of the invention as defined by the appended claims.

Claims

1. A mouthpiece for an inhalation delivery device, characterized in that the mouthpiece (16) comprises a mouth intake (162) and a wind powder suction channel, the oral cavity containing part (162) comprises a suction end surface positioned at one side of the oral cavity during suction, a wind powder suction port (16A) and a peripheral wind suction port (16B), the wind powder suction opening (16A) and the peripheral wind suction opening (16B) are arranged on the suction end face, the air and powder suction port (16A) is communicated with the air and powder suction passage to provide suction force for the medicinal powder, the peripheral air suction port (16B) is arranged outside the air powder suction port (16A) and communicated with the outside air to form peripheral air outside the air powder suction port (16A) so that when the medicine powder passes through the oral cavity, the peripheral wind outside the main passage for the flow of the medicinal powder provides isolation between the medicinal powder and the oral cavity wall.

2. The mouthpiece of claim 1 wherein the mouth intake section (162) includes at least two of the peripheral air suction ports (16B) at different positions in the circumferential direction of the air-powder suction port (16A).

3. A mouthpiece for an inhalation delivery device according to claim 1, wherein the suction end face comprises a curved surface which is convex to the side away from the oral cavity.

4. A mouthpiece for an inhalation delivery device as claimed in claim 3, wherein the curved surface is an arcuate cylindrical surface.

5. The nozzle for an inhalation delivery device according to any of claims 1 to 4, wherein the nozzle (16) further comprises a cyclone structure provided on the air-powder suction channel; and/or the suction nozzle also comprises a rectifying structure arranged on the air powder suction channel.

6. The mouthpiece of claim 5, wherein the swirl structure comprises a swirl vane disposed within the air powder suction channel, the swirl vane being fixedly disposed relative to the air powder suction channel.

7. The mouthpiece of claim 6, wherein the ends of the swirl vanes are connected to the inner wall of the wind powder suction channel.

8. The nozzle for an inhalation delivery device of claim 5, wherein said swirl structure is disposed downstream of said fairing structure.

9. An inhalation delivery device, characterized in that it comprises a mouthpiece according to any of claims 1 to 8 for an inhalation delivery device.

10. The inhalation delivery device according to claim 9, further comprising a housing including a vent port for introducing outside air, a cartridge housing chamber for housing a cartridge, and a gas accommodating space, both of which communicate with the vent port, the air-powder suction port communicating with the cartridge housing chamber to suck the medicine powder, and the peripheral air suction port communicating with the gas accommodating space to communicate with outside air.