CN110141294A - medical coil - Google Patents

Abstract

The present invention provides a medical coil, which includes a spring and at least one developing mark, and the developing mark is sleeved on the outside of the spring and/or arranged inside the spring, thus, on the one hand, it is possible to use these The specific position and shape of the medical coil can be observed during or after implantation of the developing mark, which effectively solves the problem of poor developing performance of the existing coil; on the other hand, since the developing mark is sleeved on the outside of the spring and Therefore, the setting of the developing marker will not affect the physical properties such as the three-dimensional structure and stiffness of the spring itself, and effectively realize the embolization treatment of intracranial aneurysms.

Description

medical coil

technical field

The invention relates to the technical field of medical instruments, in particular to a medical spring coil.

Background technique

Ruptured intracranial aneurysms have high morbidity and mortality. With the improvement of medical technology, the development of device materials and the accumulation of experience of neurointerventional physicians, endovascular therapy has become the preferred treatment method to reduce the rebleeding rate and mortality of ruptured intracranial aneurysms. Among the many treatment methods, aneurysm embolization is the most widely used, including embolic coils, liquid embolic agents, intratumoral embolization devices, and balloon/stent-assisted techniques. Among them, embolic coils have attracted more and more attention from clinicians and researchers due to their advantages of convenient operation, stable implantation, safety and effectiveness, and have gradually become the mainstream method for clinical treatment of intracranial aneurysms.

According to the material and structural design, the coils currently used clinically can be divided into bare metal coils (including two-dimensional coils and three-dimensional basket coils) and surface-modified coils. Bare metal coils are currently the most widely used coils, which are safe and effective for intracranial ruptured aneurysms, and can reduce early rebleeding rates and long-term mortality. Typical bare metal coils are made of platinum-tungsten alloy and other metal materials, which have good biocompatibility and good imaging effect. Surface-modified coils include hydrogel coils, bioactive coated coils and ciliated coils. This type of coils is clinically compared with bare metal coils by surface modification of bare metal coils. It showed better aneurysm cavity filling rate, shorter aneurysm thrombosis and aneurysm neck endothelialization cycle, and lower medium and long-term recurrence rate and rebleeding rate. However, patients with intracranial aneurysms often present with headaches, eye movement disorders, and limb swelling. The coils currently used clinically (including bare metal coils and surface-modified coils) are not degradable. Although they can lead to intratumoral thrombus and organization after packing, the tumor body maintains its inherent size and will continue to treat the tumor outside the tumor. Nerves, blood vessels and organs are compressed, and clinical symptoms caused by mass effect cannot be eliminated. In addition, the main bodies of bare metal coils and surface-modified coils are all metal structures, which cannot be degraded in vivo, so the safety and stability of long-term implantation in vivo remains to be investigated.

At present, there are patents mentioning absorbable (or degradable) spring coils, and the preparation materials used include PLGA, PGA, magnesium alloy, etc. However, none of these materials can be developed under X-rays. Therefore, when designing a degradable coil, it is necessary to design and add a developing component on the spring to endow the degradable coil with developing properties. For example, the developing ring is bonded to both ends of the degradable coil, or the coil made of developing wire and the coil of degradable metal wire are wound together, or the degradable material and the developing material are processed to form an integrated structure and then wound Make a three-dimensional spring, etc., to give the coil developability. However, although the volume of these spring coils has decreased after the degradation of the absorbable material, they still retain a non-degradable three-dimensional structure, and the occupying effect still exists.

In addition, there are still some defects in the degradable coils using the above-mentioned development structure: 1) The degradable or absorbable materials themselves do not have developability, so the development effect of the degradable coils is poor at present, or, in order to achieve Necessary development effect, the volume ratio of the degradable or absorbable material used in the entire coil is limited, generally not higher than 60%, so there is still an obvious occupying effect; 2) When the degradable material in the coil Or after the absorbable material is degraded or absorbed, the imaging structure may fall off from the coil or even fall out of the neck of the aneurysm, resulting in distal vascular blockage and even life-threatening.

Therefore, it is necessary to improve the existing medical coils to solve the above problems.

Contents of the invention

The purpose of the present invention is to provide a medical coil, which can effectively solve the problem of poor developing performance of the existing coil.

In order to achieve the above object, the present invention provides a medical coil, which includes a spring and at least one developing mark, and the developing mark is sleeved on the outside of the spring and/or arranged inside the spring.

Optionally, at least part of the material of the spring is a biodegradable material or a bioabsorbable material.

Optionally, the biodegradable material or bioabsorbable material accounts for 70%-95% of the volume of the coil.

Optionally, the biodegradable or bioabsorbable material includes at least one of polylactic acid, polyglycolic acid, polyurethane, and polylactic acid-glycolic acid copolymer.

Optionally, at least two of the developing marks are arranged at intervals along the axial direction of the spring.

Optionally, the developing mark is sleeved on the outer wall of the spring or embedded in the inner wall of the spring through an interference mechanical connection.

Optionally, the spring coil further includes at least one anti-unrotation component, the anti-unrotation component is passed through the inside of the spring, and the two ends of the anti-unrotation component are respectively connected to the two ends of the spring. end connection.

Optionally, the developing mark is arranged inside the spring, and the anti-unrotation component is penetrated inside the developing mark; the anti-unrotating component and the developing mark are bonded by an adhesive, Alternatively, the anti-untwisting component forms knots at both ends of the developing mark, and the outer diameter of the knot is larger than the inner diameter of the developing mark.

Optionally, the number of the developed marks is more than two, and the distance between two adjacent developed marks ranges from 3 mm to 30 mm.

Optionally, the number of the developing marks is more than two, at least one of the developing marks is located outside the spring, and at least one of the developing marks is arranged inside the spring.

Optionally, the size of the developing mark extending along the axial direction of the spring coil is in the range of 0.005 inches to 0.025 inches.

Optionally, the outer diameter of the visible marker sleeved on the outside of the spring ranges from 0.010 inch to 0.0165 inch.

Optionally, the outer diameter of the visible mark disposed inside the spring is in a range of 0.002 inches to 0.010 inches.

Optionally, the developing mark is a ring-shaped, tubular or spring-shaped structure.

Optionally, the material of the developing mark is one or more combinations of stainless steel, platinum, gold, rhodium, rhenium, palladium, iridium and tungsten.

Optionally, the material of the anti-unrotation component is a non-degradable polymer material or a non-degradable metal material.

Optionally, the polymer material includes at least one of polypropylene, polyethylene, and polyisoprene; the metal material includes nickel-titanium alloy, platinum-tungsten alloy, titanium-nickel-copper alloy, titanium-nickel-iron alloy, titanium At least one of nickel-chromium alloy, copper-nickel alloy, copper-aluminum alloy and copper-zinc alloy.

Optionally, the spring coil further includes connecting pieces arranged at both ends of the spring, and the connecting pieces respectively connect the two ends of the anti-unrotation component and the two ends of the spring together.

Optionally, the connecting piece is a smooth curved structure.

Optionally, the material of the connector is a light-cured or naturally cured viscous liquid, and the viscous liquid can be cured under light or natural environmental conditions to form the smooth curved surface structure.

Optionally, the viscous liquid includes at least one of epoxy glue or acrylated polyurethane.

Optionally, the connecting member is connected to the spring and/or the anti-unrotation component by bonding.

Optionally, the outer diameter of the connector is larger than the inner diameter of the visible mark.

Compared with the prior art, the medical coil of the present invention has the following beneficial effects:

1. The medical coil of the present invention comprises a spring and at least one developing mark, and the developing mark is sleeved on the outside of the spring and/or arranged inside the spring, thus, on the one hand, it is possible to use these developing marks to Marking observes the specific position and shape of the medical coil during or after implantation, effectively solving the problem of poor developing performance of the existing coil; on the other hand, since the developing marker is sleeved on the outside of the spring and/or Or internally, therefore, the setting of the developing marker will not affect the physical properties such as the three-dimensional structure and stiffness of the spring itself, effectively realizing the embolization treatment of intracranial aneurysms.

2. Furthermore, at least part of the springs in the medical coil of the present invention are made of bioabsorbable and/or degradable materials, so they have both degradability and imaging properties. On the one hand, after the coil is implanted in a blood vessel, it can Safe and effective embolization of intracranial aneurysm, rapid fibrosis of the thrombus in the aneurysm, as the degradable material of the spring is absorbed and/or degraded, the fibrous tissue in the aneurysm shrinks continuously, and the aneurysm shrinks continuously, so that the aneurysm can be greatly improved It can reduce the occupying effect of the spring coil to a certain extent, and at the same time avoid the long-term safety problems after the metal ring is implanted; Maintaining the original three-dimensional structure of the coil can basically completely eliminate the long-term occupying effect of the coil in the aneurysm, so it can effectively solve the problem of occupying effect and the demand for imaging performance at the same time.

3. Further, in the medical coil of the present invention, at least two of the developing marks are arranged at intervals along the axial direction of the spring, and these developing marks are sleeved on the outside of the degradable spring at intervals and/or arranged on a degradable spring. The inside of the degradable spring, the cooperating arrangement of the development mark and the degradable spring, compared with the existing development wire material and the degradable material winding or the spring coil formed by the two materials, the development effect is better, so it can Under the premise of obtaining the same developing effect, using less developing material can make the bioabsorbable and/or degradable material account for a higher volume percentage of the entire coil, which in turn makes the coil have a short degradation cycle and a high degradation ratio. Features, which bring more significant and thorough effects to solve the mass effect and long-term security problems.

4. Further, in the medical coil of the present invention, the developing mark is sleeved on the outside of the spring and/or arranged inside the spring through an interference mechanical connection, that is, the developing mark can be effectively fixed on the spring On, and in the process of the medical coil being pushed into the blood vessel, it can keep stable without slipping, and then at the same time use the developing performance of the developing mark to accurately position and release the coil, so as to ensure that the coil can be accurately implanted into the blood vessel lesion location.

5. Further, the medical coil of the present invention also includes an anti-untwisting component, the anti-untwisting component is passed through the inside of the developing mark, or is connected with the developing mark in a corresponding way, thus, it can be passed through Anti-untwisting parts to keep the position of the visualization mark unchanged in the axial direction, so as to accurately locate and observe the specific position and three-dimensional shape of the coil during and after implantation, and also prevent the visualization mark from degrading after the spring It falls off from the coil, thereby avoiding the problem that the existing developed markers are easy to fall off or even fall outside the neck of the aneurysm, resulting in blockage of distal blood vessels and even life-threatening problems.

6. Further, the medical spring coil of the present invention includes a smooth curved surface structure arranged at both ends of the spring, and the smooth curved surface structure can fix the anti-unrotation component and the two ends of the spring together, thereby increasing the smoothness of the two ends of the spring coil. In order to reduce the coil push resistance and reduce the possible damage to the tumor wall when the coil is pushed into the blood vessel when the coil is pushed into the blood vessel, and after the spring is mostly degraded or completely degraded, the smooth surface The structure and the anti-untwisting member may remain operatively connected to the developer marker to further prevent the risk of the developer marker falling off the coil after the spring degrades.

Description of drawings

Fig. 1 is a schematic cross-sectional structure diagram of a medical coil according to Embodiment 1 of the present invention.

Fig. 2 is a schematic cross-sectional structure diagram of the medical coil according to the second embodiment of the present invention.

Fig. 3 is a schematic cross-sectional structure diagram of the medical coil according to the third embodiment of the present invention.

Wherein the reference signs are as follows:

1-developed mark; 2-spring; 3-anti-untwisting component; 4-smooth surface structure; L1-line width of developed mark; L2-space between two adjacent developed marks.

Detailed ways

In order to make the purpose and features of the present invention more obvious and understandable, the technical solutions of the present invention will be described in detail below in conjunction with the accompanying drawings. However, the present invention can be implemented in different forms and should not be limited to the described embodiments. In addition, the term "and/or" in this article means an alternative or both; the term "connection" includes direct connection and indirect connection.

Embodiment one

Please refer to FIG. 1 , this embodiment provides a medical coil, including a spring 2 , at least one developing mark 1 , at least one anti-unrotation component 3 and two smooth curved surface structures 4 .

The spring 2 is the main structure of the medical spring coil, which can be a spring structure with uniform shape formed by winding corresponding wires on the mandrel, and generally presents a tubular structure with a cavity, so that the present embodiment Medical coils form embolic coils. The material of at least part of the spring 2 is a biodegradable material or a bioabsorbable material, and the volume of the biodegradable material or bioabsorbable material accounts for 70% to 95% of the entire volume of the medical coil, thus making this implementation The medical coil of this example has both degradability and imaging properties. On the one hand, after the coil is implanted into the blood vessel, it can safely and effectively embolize the intracranial aneurysm, causing rapid fibrosis of the thrombus in the aneurysm. With the degradable material of the spring The fibrous tissue in the tumor shrinks continuously, making the aneurysm shrink continuously, which can greatly reduce the space occupation effect of the coil, and at the same time avoid the long-term safety problems after the implantation of the metal coil On the other hand, after the coil is degraded or absorbed, the remaining non-degradable part including the development mark no longer maintains the original three-dimensional structure of the coil, which can basically completely eliminate the long-term occupying effect of the coil in the aneurysm, Therefore, the problem of space occupation effect and the demand for developing performance can be effectively solved at the same time. Wherein, the bioabsorbable/biodegradable material includes at least one of polylactic acid (PLA), polyglycolic acid (PGA), polyurethane (PU), and polylactic-co-glycolic acid (PLGA/PGLA). Among them, PLA, PGA, and PGLA are preferred, so that the degradable/absorbable part of the medical coil has the characteristics of short degradation cycle and high degradation ratio, which is beneficial to reduce or even eliminate the occupying effect in a relatively short period of time.

At least one developing mark 1 is sleeved on the outer wall (i.e. the outside) of the spring 2, thus, on the one hand, the specific position and shape of the medical coil can be observed during or after implantation by means of these developing marks 1, effectively It solves the problem of poor development performance of the existing spring coil; on the other hand, since the development mark 1 is sleeved outside the spring 2, the setting of the development mark 1 will not affect the physical properties such as the three-dimensional structure and stiffness of the spring 2 itself. Performance, effective embolization of intracranial aneurysms.

The development mark 1 can be a ring structure, a tubular structure or a spring structure, and the connection mode between the development mark 1 and the spring 2 is an interference mechanical connection, so that the setting of the development mark 1 will not affect the structure of the spring 2 itself Under the premise, the developing mark 1 can be effectively fixed on the spring 2, and the developing mark 1 can be kept stable and will not slip when the medical coil is pushed into the blood vessel of the human body. In addition, the material selection of the development mark 1 needs to meet the requirements of not affecting the development effect of the medical coil under X-rays, and at the same time, it will not adversely affect the softness and pushability of the medical coil. Therefore, in this embodiment, the development The material marked 1 is an X-ray impenetrable material, including one or more combinations (ie, alloys) of stainless steel, platinum, gold, rhodium, rhenium, palladium, and tungsten. The size design of the imaging mark 1 needs to be determined according to the size of the aneurysm to be implanted, and at the same time, it needs to meet the requirements for the softness and flexibility of the medical coil while not affecting the imaging effect of the medical coil under X-rays. Pushability will not be adversely affected, therefore, in this embodiment, the axial dimension L1 of the developed mark 1 (that is, the dimension that the developed mark 1 extends along the length direction x of the anti-unrotation member 3) ranges from 0.005 inches to 0.025 inches. Between inches, the preferred size is 0.01 inches to 0.016 inches, and the outer diameter of each developing mark 1 (that is, the dimension along the direction y perpendicular to the anti-unrotation component 3) ranges from 0.010 inches to 0.0165 inches, preferably The size is 0.0135 inches to 0.0145 inches, so as to achieve the interference mechanical connection with the spring 2, and at the same time match the size of the required implanted aneurysm to prevent damage to the blood vessel during the implantation process. Therefore, the outer diameter of the spring 2 The size needs to be designed according to the space size of the desired implantation site, and the outer diameter of the spring 2 needs to match the inner diameter of the spring 2 of the developing mark 1 .

In addition, in order to match the size of the aneurysm to be implanted and to ensure that the imaging markers can be evenly distributed in the aneurysm after all the coils are implanted, so as to facilitate the diagnosis of the curative effect during and after the operation, the imaging marker 1 set in this embodiment The number of these development marks 1 is not less than two, and these development marks 1 are arranged at intervals along the axial direction of the spring 2, and are all sleeved on the outside of the spring 2. Compared with the spring coil wound by degradable material or integrally formed by two materials, the developing wire material has better developing effect, so it can use less developing material under the premise of obtaining the same developing effect, which can make the spring in spring 2 Bioabsorbable and/or degradable materials account for a higher volume percentage of the entire coil, reaching 70% to 95%, which in turn makes the coil have the characteristics of short degradation cycle and high degradation ratio, which is helpful for solving the occupation effect and long-term safety. Questions bring about a more pronounced and thorough effect. In a specific implementation, these developing marks 1 can be evenly arranged at equal intervals along the axial direction of the spring 2, specifically, these developing marks 1 can be evenly arranged with the distance L2 between every two adjacent developing marks 1 being the same value. Mark 1, the distance L2 ranges, for example, from 3 mm to 30 mm, and preferably ranges from 5 mm to 10 mm. The overall length of the spring 2 may be equal to or greater than the sum of the sum of the axial dimensions L1 of all the developed marks 1 and the sum of all the distances L2. In other embodiments, the plurality of developing marks 1 may also be arranged at unequal intervals along the x direction, for example, they are arranged densely near the two ends of the spring coil and sparsely arranged near the middle.

The anti-unrotation component 3 is a thread-like structure, pierced inside the spring 2 , and extends along the axial direction of the spring 2 , and the two ends of the anti-unrotation component 3 are respectively connected to the two ends of the spring 2 . The anti-unrotation component 3 is made of non-degradable materials, such as non-degradable polymer materials or non-degradable metal materials including alloys, and the polymer materials include but not limited to polypropylene PP, polyethylene and polyisoprene; the metal materials include but not limited to nickel-titanium alloy, platinum-tungsten alloy, titanium-nickel-copper alloy, titanium-nickel-iron alloy, titanium-nickel-chromium alloy, copper-nickel alloy, copper-aluminum alloy and Copper-zinc alloy, etc. Among them, the purpose of anti-unrotation component 3 includes: first, to realize the anti-unrotation of spring 2; Accurately locate and observe the specific position and three-dimensional shape of the spring coil, and at the same time prevent the problem that the developed mark 1 falls off from the coil after the degradable part of the spring 2 is degraded, thereby avoiding the existing developed mark from easily falling off or even falling to the Aneurysm outside the neck can lead to distal blood vessel blockage and even life-threatening problems.

The smooth curved surface structure 4 can fix the two ends of the anti-unrotation component 3 and the two ends of the spring 2 together. The purpose of setting the smooth surface structure 4 includes: firstly, to increase the smoothness of both ends of the coil, so as to reduce the pushing resistance of the coil when the coil is pushed into the blood vessel; The possible damage to the aneurysm wall during the process; the second is to maintain an effective connection with the development mark 1 together with the anti-unrotation component 3 after the spring 2 is mostly degraded or completely degraded, so as to maintain the position of the development mark 1 in the axial direction Invariant to allow accurate positioning and observation of the specific position and three-dimensional shape of the coil during and after coil implantation and to prevent the risk of the visible marker falling off the coil after degradation of the degradable part of the spring 2 . In this embodiment, the connection method between the smooth curved structure 4 and the spring 2 is bonding, and the material of the smooth curved structure 4 is preferably a light-cured or naturally cured viscous liquid, so that the viscous liquid can be used under light or a specific natural environment. The principle of curing can be used to form the smooth curved surface structure 4 and bond the smooth curved surface structure 4 to the spring 2, wherein the material of the viscous liquid includes but not limited to epoxy resin glue, acrylated polyurethane and the like. Preferably, the outer diameter of the smooth curved structure 4 (that is, the dimension in the direction y perpendicular to the length of the anti-untwisting component) is slightly larger than the inner diameter of the developing mark 1, and the axial dimension of the smooth curved structure 4 (that is, along the anti-unrotation component) The size in the direction x of the length of the unrotating part) is slightly larger than the axial dimension of the developing mark 1, so that after the spring 2 is completely degraded, the anti-unrotating part 3 and the smooth curved surface structure 4 at both ends remain effectively connected to the developing mark 1 , which can prevent the degradable part of the spring 2 from being displaced and falling out from both ends of the spring coil after the degradable part of the spring 2 is degraded.

To sum up, the medical coil of this embodiment includes a spring and at least one developing mark, and the developing mark is sheathed on the outside of the spring, so that, on the one hand, it is possible to use these developing marks during implantation or Observing the specific position and shape of the medical coil after implantation effectively solves the problem of poor developing performance of the existing coil; on the other hand, since the developing mark is sleeved outside the spring, the setting of the developing mark will not It affects the physical properties such as the three-dimensional structure and stiffness of the spring itself, and effectively realizes the embolization treatment of intracranial aneurysms. In addition, the medical coil of this embodiment has both degradability and visualization because at least part of the spring is degradable and is provided with at least one imaging mark, so it can embolize intracranial aneurysms safely and effectively after the coil is implanted in a blood vessel. Fibrosis of the thrombus in the aneurysm, and as the degradable material of the spring is absorbed and/or degraded, the fibrous tissue in the aneurysm shrinks continuously, so that the aneurysm shrinks continuously, so that the coil can be greatly reduced or even eliminated Occupation effect, and at the same time, it can avoid the safety problems after the metal ring is implanted. In addition, at least two developing marks are arranged at intervals along the axial direction of the spring, and each developing mark is sleeved outside the spring without affecting the structure of the spring itself, and the developing marks can be effectively connected through interference mechanical connection. Fixed on the spring, it can keep stable and will not slip when the coil is pushed into the blood vessel. At the same time, the development performance of the developed mark is used to accurately position and release the degradable coil to ensure that the coil can be accurately implanted. Into the lesion position, and in the long-term implantation process after surgery, it is possible to follow up and check whether the non-degradable parts such as the anti-untwisting parts in the coil, smooth curved surface structure, and the remaining non-degradable materials of the spring are Shifting or falling off ensures the safety and stability of the long-term implantation of the coil. Further, the smooth curved surface structure can fix the anti-unrotation component and the two ends of the spring together, thereby increasing the smoothness of the two ends of the coil to reduce the push resistance of the coil when the coil is pushed into the blood vessel As well as reducing the possible damage to the aneurysm wall caused by the coil when filling the aneurysm, and after the spring is mostly degraded or completely degraded, the smooth surface structure and the anti-unrotation component can maintain an effective connection with the developing mark, thereby preventing the developing mark from being The degradable material of the spring is degraded and falls and shifts.

Embodiment two

Please refer to FIG. 2 , this embodiment provides a medical coil, including a spring 2 , at least one developing mark 1 , at least one anti-unrotation component 3 and two smooth curved surface structures 4 . The main difference between the degradable coil of this embodiment and the medical coil of Embodiment 1 is that each developing mark 1 is sheathed in the interior of the spring 2 (which may be referred to as an inner cavity). Since the developing marker 1 is embedded inside the spring 2, and the outer diameter of the spring 2 needs to be determined according to the size of the aneurysm to be implanted, the outer diameter of the developing marker 1 needs to be determined according to the inner diameter of the spring 2 size, and also need to meet the conditions that do not affect the developing effect of the degradable coil under X-rays and the softness of the coil. Therefore, the outer diameter of the developing mark 1 in this embodiment ranges from 0.002 inches to 0.010 inches. inches, with a preferred size of 0.004 inches to 0.0065 inches.

In this embodiment, each developing mark 1 is sleeved inside the spring 2, and the following three schemes can be specifically adopted:

1) Each developing mark 1 is embedded on the inner wall of the spring 2 through an interference mechanical connection. In this case, the anti-unrotation component 3 is penetrated inside each developing mark 1, but each developing mark 1 may not be connected with the anti-unrotating The parts 3 are in contact, or there may be contact, or some of the developed marks 1 are in contact with the anti-untwisting part 3, and some of the developed marks 1 are not in contact with the anti-untwisting part 3;

2) There is a smaller hole in the center of each developing mark 1 for the anti-untwisting component 4 to pass through, and the anti-untwisting component 3 is respectively tied with a knot at both ends of each developing mark 1 to form a knot. The outer diameter is greater than the inner diameter of the hole in the center of the developing mark 1. In this case, the anti-unrotation component 3 is penetrated inside each developing mark 1, but each developing mark 1 and the spring 2 may or may not be connected;

3) There is a small hole in the center of each developing mark 1 for the anti-unrotation component 3 to pass through, and the position where the anti-unrotation component 3 is in contact with the developing mark 1 is fixed together by adhesive bonding. In this case, The anti-unrotation component 3 is installed inside each developing mark 1 , and each developing mark 1 can be connected with the spring 2 or not.

The material selection of each component of the medical coil of this embodiment and the design of other dimensions are the same as those of the medical coil of Embodiment 1, and will not be repeated here.

Compared with the medical coil of Example 1, the medical coil of this embodiment has a smoother outer surface, which is beneficial to reduce the push resistance in the process of pushing the medical coil into the blood vessels of the human body, avoiding damage to tissues, and more importantly, due to various The developing marks are all sleeved inside the spring, so it can prevent the developing marks in the spring from sliding or even falling off due to external resistance and other environmental factors, and enhance the structural stability of the developing marks in the process of pushing the medical coil into the human blood vessel.

In addition, in the medical spring coil of this embodiment, at least two developing marks 1 can be provided, and these developing marks 1 are arranged at intervals along the axial direction of the spring 2, and can be arranged at equal intervals or at unequal intervals, and these The development marks 1 are all set inside the degradable spring 2, thus making the medical coil of this embodiment, compared with the existing coils in which the development wire is wound with the degradable material or the two materials are integrally formed, the development The effect is better, so it is possible to use less developing material under the premise of obtaining the same developing effect, which can make the bioabsorbable and/or degradable material account for a higher volume percentage of the entire coil, thereby enabling the coil to have a degradation cycle The characteristics of short duration and high downgrading ratio bring about more significant and thorough effects on solving mass effect and long-term security problems.

Embodiment three

Please refer to FIG. 3 , this embodiment provides a medical coil, including a spring 2 , at least one developing mark 1 , at least one anti-unrotation component 3 and two smooth curved surface structures 4 . The main difference between the medical coil of this embodiment and the medical coil of Embodiment 1 is that: the development mark 1 is divided into two types, one kind of development mark 1a is embedded inside the spring 2, and the other kind of development mark 1b is a sleeve It is arranged on the outside of the spring 2 , and the anti-unrotation component 3 is passed through the inside of each developing mark 1 a of the spring 2 . Since the developing mark 1b is sleeved on the outside of the spring 2, and the developing mark 1a is embedded inside the spring 2, the outer diameter of the developing mark 1b needs to be determined according to the size of the aneurysm to be implanted. The developing mark 1a The outer diameter of the spring 2 needs to be determined according to the size of the inner diameter of the spring 2. At the same time, the setting of the development marks 1a and 1b also needs to meet the conditions of not affecting the development effect of the medical coil under X-rays and the softness of the medical coil. Therefore, in this embodiment, the outer diameter range of each developed mark 1a is between 0.002 inch and 0.010 inch, and the preferred size is 0.004 inch to 0.0065 inch, and the outer diameter range of each developed mark 1b is between 0.010 inch and 0.0165 inch. , the preferred size is 0.0135 inches to 0.0145 inches.

In this embodiment, each development mark 1a is sleeved inside the spring 2, and the following three schemes can be specifically adopted:

1) Each development mark 1a is embedded on the inner wall of the spring 2 through an interference mechanical connection. In this case, the anti-unrotation component 3 is penetrated inside each development mark 1a, but each development mark 1a may not be connected with the anti-unrotation Rotation part 3 contact, also can all be in contact, or, wherein some developing marks 1a are in contact with anti-unrotation part 3, other development marks 1a are not in contact with anti-unrotation part 3;

2) There is a smaller hole in the center of each developing mark 1a for the anti-untwisting component 4 to pass through, and the anti-untwisting component 3 is respectively tied with a knot at both ends of each developing mark 1a to form a knot. The outer diameter is larger than the inner diameter of the hole in the center of the developed mark 1. In this case, the anti-unrotation component 3 is penetrated inside each developed mark 1a, but each developed mark 1a can be connected to the spring 2 or not;

3) There is a small hole in the center of each developed mark 1a for the anti-unrotation component 3 to pass through, and the position where the anti-unrotation component 3 is in contact with the developed mark 1a is fixed together by adhesive bonding. In this case, The anti-unrotation component 3 is disposed inside each developing mark 1a, and each developing mark 1a can be connected to the spring 2 or not.

The material selection of each component of the medical coil of this embodiment and the design of other dimensions are the same as those of the medical coil of Embodiment 1, and will not be repeated here.

In addition, in the medical coil of this embodiment, the development marks 1b sleeved outside the spring 2 and the development marks 1a nested inside the spring 2 are alternately arranged along the axial direction of the spring 2, and the corresponding two development marks 1 There is an interval between them, and the interval can be uniform or non-uniform.

The medical coil of this embodiment, compared with the medical coil of Embodiment 1, since the development mark includes the development mark embedded in the spring and the development mark sleeved on the outside of the spring, therefore, it is possible to use the The developing marks and anti-untwisting parts in the interior of the medical coil enhance the structural stability of the medical coil, which can make each developing mark more stable and not slip when the medical coil is pushed into the human blood vessel.

It should be noted that, although the medical spring coils in each of the above-mentioned embodiments use a smooth curved surface structure as a connector to connect the two ends of the anti-unrotation component and the two ends of the spring, the technical solution of the present invention It is not limited thereto, and in other embodiments of the present invention, the smooth curved surface structure may be replaced by other connectors with non-smooth curved surfaces, for example, polyhedral connectors and the like.

In addition, although the medical coils in each of the above-mentioned embodiments are provided with anti-untwisting parts, the connection between the non-degradable anti-untwisting parts and the smooth curved surface structures at both ends prevents the development mark from detaching from the spring after the spring is degraded. However, the technical solution of the present invention is not limited thereto. In other embodiments of the present invention, any suitable method and structure can be used to ensure that the set developing structure is not only located at both ends of the spring coil , can also be located on the middle section between the two ends of the coil, and the development mark will not fall off from the coil after the spring is degraded. The spring is a structure in which two spring bodies are nested together, and the two ends of the two spring bodies are respectively connected together, and the inner spring body is non-degradable, and the outer spring body is at least partially degradable. In this case Next, the internal non-degradable spring body can be used to keep the position of the development mark in the axial direction unchanged, so that the shape of the spring coil can be accurately positioned and observed during and after implantation, and at the same time, it can also prevent the development mark After the spring is degraded, it falls off from the coil or even falls outside the neck of the aneurysm, causing distal blood vessel blockage and even life-threatening problems. At the same time, the degradability of the external spring is used to reduce the overall occupying effect of the coil.

Obviously, those skilled in the art can make various changes and modifications to the invention without departing from the spirit and scope of the invention. Thus, if these modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalent technologies, the present invention also intends to include these modifications and variations.

Claims (23)

1. a kind of medical spring ring, which is characterized in that including spring and at least one developing mark, the developing mark is set in The outside of the spring and/or the inside for being set to the spring.

2. spring ring as described in claim 1, which is characterized in that the material of at least partly described spring is biodegradable material Material or bioabsorbable material.

3. spring ring as claimed in claim 2, which is characterized in that the biodegradable material or bioabsorbable material The percentage that volume accounts for the volume of the spring ring is 70%~95%.

4. spring ring as claimed in claim 2, which is characterized in that the biodegradable material or bioabsorbable material packet Include at least one of polylactic acid, polyglycolic acid, polyurethane, poly lactide-glycolide acid.

5. spring ring as claimed in claim 1 or 2, which is characterized in that at least two developing marks are along the spring Axially spaced-apart setting.

6. spring ring as claimed in claim 1 or 2, which is characterized in that the developing mark passes through interference mechanical connection manner Set is set on the outer wall of the spring or on the inner wall of the spring.

7. spring ring as claimed in claim 1 or 2, which is characterized in that further include at least one anti-component that untwists, the anti-solution Rotation component is arranged in the inside of the spring, and the both ends of the anti-component that untwists are connect with the both ends of the spring respectively.

8. spring ring as claimed in claim 7, which is characterized in that the developing mark is set to the inside of the spring, institute State the inside that the anti-component that untwists is arranged in the developing mark；The anti-component that untwists is viscous by adhesive with the developing mark It connects, alternatively, the anti-component that untwists is respectively formed at the both ends of the developing mark and knots, and the outer diameter to knot is greater than institute State the internal diameter of developing mark.

9. spring ring as claimed in claim 1 or 2, which is characterized in that the quantity of the developing mark is two or more, adjacent The range of spacing between two developing marks is 3 millimeters~30 millimeters.

10. spring ring as claimed in claim 1 or 2, which is characterized in that the quantity of the developing mark is two or more, until A few developing mark is located at the outside of the spring, and at least one described developing mark is set to the interior of the spring Portion.

11. spring ring as claimed in claim 1 or 2, which is characterized in that the developing mark prolongs along the axial direction of the spring ring The range for the size stretched is 0.005 inch~0.025 inch.

12. spring ring as claimed in claim 1 or 2, which is characterized in that be set in the development mark of the outside of the spring The range of the outer diameter of note is 0.010 inch~0.0165 inch.

13. spring ring as claimed in claim 1 or 2, which is characterized in that be set to the developing mark of the spring inner Outer diameter range be 0.002 inch~0.010 inch between.

14. spring ring as claimed in claim 1 or 2, which is characterized in that the developing mark is cyclic annular, tubulose or spring like Structure.

15. spring ring as claimed in claim 1 or 2, which is characterized in that the material of the developing mark be stainless steel, platinum, One of gold, rhodium, rhenium, palladium, iridium and tungsten or multiple combinations.

16. spring ring as claimed in claim 7, which is characterized in that the material of the anti-component that untwists is nondegradable poly- Close object material or nondegradable metal material.

17. spring ring as claimed in claim 16, which is characterized in that the polymer material include polypropylene, polyethylene and At least one of polyisoprene；The metal material includes Nitinol, platinum-tungsten alloys, titanium monel, the conjunction of titanium ferronickel At least one of gold, titanium nichrome, corronil, albronze and ormolu.

18. spring ring as claimed in claim 7, which is characterized in that it further include the connector that the both ends of the spring are set, The both ends at the both ends of the anti-component that untwists and the spring are respectively connected together by the connector.

19. spring ring as claimed in claim 18, which is characterized in that the connector is smooth surface structure.

20. spring ring as claimed in claim 19, which is characterized in that the material of the connector is photocuring or spontaneous curing Viscous liquid, the viscous liquid can be solidified to form the smooth surface structure under illumination or natural environmental condition.

21. spring ring as claimed in claim 20, which is characterized in that the viscous liquid includes epoxide-resin glue or acrylic acid Change at least one of polyurethane.

22. spring ring as claimed in claim 18, which is characterized in that the connector and the spring and/or the anti-solution The connection type for revolving component is bonding.

23. spring ring as claimed in claim 18, which is characterized in that the outer diameter of the connector is greater than the developing mark Internal diameter.