CN110101956A - Guiding catheter - Google Patents
Guiding catheter Download PDFInfo
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- CN110101956A CN110101956A CN201910358142.8A CN201910358142A CN110101956A CN 110101956 A CN110101956 A CN 110101956A CN 201910358142 A CN201910358142 A CN 201910358142A CN 110101956 A CN110101956 A CN 110101956A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0043—Catheters; Hollow probes characterised by structural features
- A61M25/0045—Catheters; Hollow probes characterised by structural features multi-layered, e.g. coated
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0043—Catheters; Hollow probes characterised by structural features
- A61M25/005—Catheters; Hollow probes characterised by structural features with embedded materials for reinforcement, e.g. wires, coils, braids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3368—Temperature
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/36—General characteristics of the apparatus related to heating or cooling
- A61M2205/3606—General characteristics of the apparatus related to heating or cooling cooled
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/36—General characteristics of the apparatus related to heating or cooling
- A61M2205/3673—General characteristics of the apparatus related to heating or cooling thermo-electric, e.g. Peltier effect, thermocouples, semi-conductors
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Abstract
Description
技术领域technical field
本发明涉及医疗器械领域,具体涉及一种指引导管。The invention relates to the field of medical devices, in particular to a guiding catheter.
背景技术Background technique
据研究表明,脑细胞对温度的变化十分明显,体温每降低l℃可使代谢率下降5%~6%。亚低温治疗是目前最有潜力的神经保护方法,也是目前临床中证实的唯一对心肺复苏后全脑缺血性脑损伤有效的治疗方法。According to research, brain cells have obvious changes in temperature, and every 1°C decrease in body temperature can reduce the metabolic rate by 5% to 6%. Mild hypothermia therapy is currently the most promising neuroprotective method, and it is also the only clinically proven effective treatment method for global ischemic brain injury after cardiopulmonary resuscitation.
指引导管是一种在介入手术中插入人体血管内的常见器械,作用主要是输送介入治疗器械、注射造影剂和药物以及监测冠状动脉内压力等。根据不同的解剖和用途,指引导管设计出多种外形,现有的指引导管有多种规格和型号,其外形尽管存在一定的差异,但往往存在相似的地方。Guide catheter is a common device inserted into human blood vessels during interventional surgery. Its main functions are to deliver interventional therapy devices, inject contrast agents and drugs, and monitor intracoronary pressure. According to different anatomy and purposes, guiding catheters are designed with various shapes. Existing guiding catheters have various specifications and models. Although there are certain differences in their shapes, they often have similarities.
在经股动脉插管至脑血管的治疗过程中,由于需要较长长度的指引导管,在人体内的流动长度会比较长,从而会造成较冷的血液从股动脉处进入,至脑部血管时较冷的血液会吸收一部分人体温度,从而到达脑部血管的温度不够低,造成治疗效果下降。During the treatment process of catheterization through the femoral artery to the cerebral blood vessels, due to the need for a long guide catheter, the flow length in the human body will be relatively long, which will cause cooler blood to enter from the femoral artery to the cerebral blood vessels When the cold blood absorbs part of the body temperature, the temperature reaching the blood vessels in the brain is not low enough, resulting in a decline in the therapeutic effect.
因此,如何在使用指引导管时降低血管的温度成为本领域技术人员亟待解决的问题。Therefore, how to reduce the temperature of the blood vessel when using the guide catheter has become an urgent problem to be solved by those skilled in the art.
发明内容Contents of the invention
本发明的目的是提供一种指引导管,以解决现有技术指引导管无法降温的问题。The purpose of the present invention is to provide a guide catheter to solve the problem that the guide catheter in the prior art cannot be cooled.
为实现上述目的,本发明提供了一种指引导管,包括导管本体、降温部件、导热板以及半导体制冷片;In order to achieve the above purpose, the present invention provides a guiding catheter, which includes a catheter body, a cooling component, a heat conducting plate and a semiconductor cooling chip;
所述降温部件设置于所述导管本体内,并沿所述导管本体的长度方向延伸,所述降温部件的一端与所述导热板连接,所述导热板贴附在所述半导体制冷片上,所述制冷片上设置有用于连接电源的导线。The cooling component is arranged in the conduit body and extends along the length direction of the conduit body. One end of the cooling component is connected to the heat conduction plate, and the heat conduction plate is attached to the semiconductor cooling sheet. The refrigerating sheet is provided with wires for connecting to a power supply.
可选地,所述降温部件包括铜丝,所述铜丝设置于所述导管本体的内部通道中,并沿所述导管本体的长度方向延伸,所述铜丝的一端与所述导热板连接。Optionally, the cooling component includes a copper wire, the copper wire is arranged in the inner channel of the conduit body, and extends along the length direction of the conduit body, and one end of the copper wire is connected to the heat conducting plate .
可选地,所述铜丝呈螺旋状。Optionally, the copper wire is helical.
可选地,所述铜丝的外表面形成有一层生物惰性薄膜。Optionally, a biologically inert film is formed on the outer surface of the copper wire.
可选地,所述铜丝的一端固定在所述导管本体的内壁上,另一端穿过所述导管本体的内壁与所述导热板连接。Optionally, one end of the copper wire is fixed on the inner wall of the conduit body, and the other end passes through the inner wall of the conduit body and is connected to the heat conducting plate.
可选地,所述导热板在与所述铜丝连接的一端呈尖刀状。Optionally, the end of the heat conducting plate connected to the copper wire is in the shape of a sharp knife.
可选地,所述降温部件包括编织网,所述编织网沿所述导管本体的长度方向延伸,所述编织网的一端与所述导热板连接。Optionally, the cooling component includes a braided mesh, the braided mesh extends along the length direction of the conduit body, and one end of the braided mesh is connected to the heat conducting plate.
可选地,所述编织网为铜编织网。Optionally, the braided mesh is copper braided mesh.
可选地,所述导管本体的管壁包括外管壁和内管壁,所述编织网被夹置于所述外管壁和所述内管壁之间。Optionally, the tube wall of the catheter body includes an outer tube wall and an inner tube wall, and the braided mesh is sandwiched between the outer tube wall and the inner tube wall.
可选地,所述外管壁为聚乙烯涂层,所述内管壁为尼龙聚四氟乙烯涂层。Optionally, the outer pipe wall is coated with polyethylene, and the inner pipe wall is coated with nylon polytetrafluoroethylene.
本发明通过半导体制冷片控制温度,温度控制精度高,保持直流电的输入稳定即可保证半导体制冷片稳定的温度,调节简单可靠,避免了体外对血液降温的需求,减少对人体和血液的损伤。The invention controls the temperature through the semiconductor refrigerating sheet, the temperature control accuracy is high, the stable temperature of the semiconductor refrigerating sheet can be guaranteed by keeping the input of direct current stable, the adjustment is simple and reliable, avoiding the need for blood cooling outside the body, and reducing the damage to the human body and blood.
附图说明Description of drawings
图1是本发明一实施方式中指引导管的结构示意图,该图中导管本体在轴向剖开;Fig. 1 is a structural schematic diagram of a guide catheter in an embodiment of the present invention, in which the catheter body is cut in the axial direction;
图2是本发明另一实施方式中指引导管的结构示意图,该图中导管本体在轴向剖开。Fig. 2 is a schematic structural view of the guiding catheter in another embodiment of the present invention, in which the catheter body is sectioned in the axial direction.
附图标记:Reference signs:
1-导管本体;11-外管壁;12-内管壁;1-catheter body; 11-outer pipe wall; 12-inner pipe wall;
2-降温部件;3-导热板;4-半导体制冷片;5-导线。2-cooling parts; 3-heat conduction plate; 4-semiconductor cooling sheet; 5-wire.
具体实施方式Detailed ways
为了能够更清楚地理解本发明的上述目的、特征和优点,下面结合附图和实施例对本发明作进一步的详细说明。可以理解的是,所描述的实施例是本发明的一部分实施例,而不是全部的实施例。此处所描述的具体实施例仅仅用于解释本发明,而非对本发明的限定。基于所描述的本发明的实施例,本领域普通技术人员所获得的所有其他实施例,都属于本发明保护的范围。In order to more clearly understand the above objects, features and advantages of the present invention, the present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the described embodiments are some, not all, embodiments of the present invention. The specific embodiments described here are only used to explain the present invention, but not to limit the present invention. All other embodiments obtained by those skilled in the art based on the described embodiments of the present invention belong to the protection scope of the present invention.
参阅图1,其示出的是本实施方式中指引导管的结构示意图,由于指引导管较长,因此未完全显示整个指引导管。本实施方式提供的指引导管包括导管本体1(图中展示的为被剖开后的结构)、降温部件2、导热板3以及半导体制冷片4;所述降温部件2设置于所述导管本体1内,并沿所述导管本体1的长度方向延伸,所述降温部件2的一端与所述导热板3连接,所述导热板3贴附在所述半导体制冷片4上,所述制冷片4上设置有用于连接电源的导线5。其中,半导体制冷片4是一种热泵,通常应用在一些空间受到限制,可靠性要求高,无制冷剂污染的场合。半导体制冷片4可吸收导热板3的热量,导热板3吸收降温部件2的热量,从而使降温部件2达到制冷的目的,从而可以保证流经指引导管的血液保持在一个低温状态,将低温血液送入到特定的脑供血动脉区域,对于治疗有更为理想的指导意义。另一方面,通过半导体制冷片4控制温度,温度控制精度高,保持直流电的输入稳定即可保证半导体制冷片4稳定的温度,调节简单可靠,避免了体外对血液降温的需求,减少对人体和血液的损伤。Referring to FIG. 1 , it shows a schematic view of the structure of the guiding catheter in this embodiment. Since the guiding catheter is relatively long, the entire guiding catheter is not fully shown. The guide catheter provided in this embodiment includes a catheter body 1 (shown in the figure as a cut-away structure), a cooling component 2, a heat conduction plate 3, and a semiconductor cooling chip 4; the cooling component 2 is arranged on the catheter body 1 and extending along the length direction of the conduit body 1, one end of the cooling component 2 is connected to the heat conduction plate 3, and the heat conduction plate 3 is attached to the semiconductor cooling sheet 4, and the cooling sheet 4 A wire 5 for connecting to a power supply is provided on the top. Among them, the semiconductor cooling chip 4 is a heat pump, which is usually used in some occasions where the space is limited, the reliability is high, and there is no refrigerant pollution. The semiconductor cooling plate 4 can absorb the heat of the heat conduction plate 3, and the heat conduction plate 3 absorbs the heat of the cooling component 2, so that the cooling component 2 can achieve the purpose of cooling, thereby ensuring that the blood flowing through the guiding catheter is kept at a low temperature state, and the low temperature blood Sending it to the specific cerebral blood supply artery area has a more ideal guiding significance for treatment. On the other hand, the temperature is controlled by the semiconductor cooling chip 4, the temperature control accuracy is high, and the stable temperature of the semiconductor cooling chip 4 can be guaranteed by keeping the input of direct current stable. Blood damage.
对于降温部件2可以采用多种结构形式,如图1所示,降温部件2可以包括铜丝,铜丝设置于所述导管本体1的内部通道中,沿所述导管本体1的长度方向延伸,所述铜丝的一端与所述导热板3连接。为了增大与血液的接触面积,更好地吸收血液热量,可以将铜丝设置成螺旋状,也就是弹簧的形状,而且铜丝的数量也可以采用多根,在图1中示出的是采用一根铜丝的示意图,本领域技术人员可以根据需求设置更多根。铜丝具有较佳地传热性能,可保证降温的及时性。Various structural forms can be adopted for the cooling part 2, as shown in Figure 1, the cooling part 2 can include copper wires, and the copper wires are arranged in the internal channel of the catheter body 1 and extend along the length direction of the catheter body 1, One end of the copper wire is connected to the heat conducting plate 3 . In order to increase the contact area with the blood and better absorb blood heat, the copper wire can be arranged in a spiral shape, that is, the shape of a spring, and the number of copper wires can also be multiple, as shown in Figure 1. Using the schematic diagram of one copper wire, those skilled in the art can set more wires according to requirements. Copper wire has better heat transfer performance, which can ensure the timeliness of cooling.
在一个具体的实施例中,所述铜丝的外表面形成有一层生物惰性薄膜。生物惰性薄膜可采用PECVD(Plasma Enhanced Chemical Vapor Deposition,是指等离子体增强化学的气相沉积法)设备镀上去。在铜丝的外表面形成生物惰性薄膜可防止铜丝直接与血液接触,极大的减小了对血液造成毒性的可能。In a specific embodiment, a biologically inert film is formed on the outer surface of the copper wire. The biologically inert film can be plated on by PECVD (Plasma Enhanced Chemical Vapor Deposition, referring to plasma enhanced chemical vapor deposition method). Forming a biologically inert film on the outer surface of the copper wire can prevent the copper wire from directly contacting the blood, greatly reducing the possibility of toxicity to the blood.
在一个具体的实施例中,所述铜丝的一端固定在所述导管本体1的内壁上,另一端穿过所述导管本体1的内壁与所述导热板3连接。为了方便铜丝与导管本体1内壁的连接,可将导管本体1在靠近两端的位置设置拐角,铜丝连接在拐角位置即可,如图1中,在导管本体1的入口端设置了拐角结构,铜丝直接连接在拐角结构上,并穿过导管本体1的内壁与所述导热板3连接。In a specific embodiment, one end of the copper wire is fixed on the inner wall of the conduit body 1 , and the other end passes through the inner wall of the conduit body 1 and is connected to the heat conducting plate 3 . In order to facilitate the connection between the copper wire and the inner wall of the catheter body 1, the catheter body 1 can be provided with corners near both ends, and the copper wire can be connected at the corner position. As shown in Figure 1, a corner structure is set at the entrance of the catheter body 1 , the copper wire is directly connected to the corner structure, and passes through the inner wall of the conduit body 1 to connect with the heat conducting plate 3 .
继续参阅图1,导热板3可为铜薄片,导热板3与半导体制冷片4紧密贴合,所述导热板3在与所述铜丝连接的一端呈尖刀状,一方面可以保证与铜丝的有效连接,另一方面可避免导热板3吸收外界多余的热量。Continuing to refer to Fig. 1, the heat conduction plate 3 can be a copper sheet, and the heat conduction plate 3 and the semiconductor refrigeration sheet 4 are closely bonded. On the other hand, it can prevent the heat conducting plate 3 from absorbing excess heat from the outside.
在上述方案中,指引导管还可以在半导体制冷片4以及导热板3的外侧设置壳体,用于保护半导体制冷片4和导热板3,壳体的形状可依据半导体制冷片4和导热板3的形状而设计,在此不予具体限定。In the above scheme, the guiding conduit can also be provided with a housing on the outside of the semiconductor refrigeration sheet 4 and the heat conduction plate 3 to protect the semiconductor refrigeration sheet 4 and the heat conduction plate 3. The shape of the housing can be based on the semiconductor refrigeration sheet 4 and the heat conduction plate 3 The shape is designed and is not specifically limited here.
对于降温部件2,除了采用铜丝的方案,还可以采用编织网的形式。参阅图2,其示出的是降温部件2包括编织网的结构示意图。同理,为了提高吸热效果,所述编织网可选为铜编织网。For the cooling component 2, in addition to the solution of using copper wire, it can also be in the form of braided mesh. Referring to FIG. 2 , it shows a schematic structural diagram of the cooling component 2 including a braided mesh. Similarly, in order to improve the heat absorption effect, the braided mesh may be a copper braided mesh.
结合图2,所述导管本体1的管壁包括外管壁11和内管壁12,所述编织网被夹置于所述外管壁11和所述内管壁12之间。采用这种结构,一方面可以保证热量的吸收,另一方面可对导管本体1起到一定的支撑作用,保证导管本体1的结构强度;此外,编织网设置在外管壁11和内管壁12之间可避免与血液的接触。编织网可以由铜丝编织而成,导热板3与编织网所有的铜丝下端焊接在一起,以保证导热板3充分的吸热。通过导热板3增加与半导体制冷片4的接触面积,保证快速地将低温传递给编织网;通过外管壁11和内管壁12的包裹将血液与编织网隔开,防止编织网直接与血液接触,避免对血液造成毒性。Referring to FIG. 2 , the tube wall of the catheter body 1 includes an outer tube wall 11 and an inner tube wall 12 , and the braided mesh is sandwiched between the outer tube wall 11 and the inner tube wall 12 . With this structure, on the one hand, it can ensure the absorption of heat, and on the other hand, it can play a certain supporting role for the catheter body 1 to ensure the structural strength of the catheter body 1; in addition, the braided mesh is arranged on the outer tube wall 11 and the inner tube wall 12 Avoid contact with blood. The braided mesh can be braided by copper wires, and the heat conducting plate 3 is welded together with the lower ends of all the copper wires of the braided mesh to ensure sufficient heat absorption of the heat conducting plate 3 . Increase the contact area with the semiconductor cooling plate 4 through the heat conduction plate 3 to ensure that the low temperature is quickly transferred to the braided mesh; the blood is separated from the braided mesh by the wrapping of the outer tube wall 11 and the inner tube wall 12 to prevent the braided mesh from directly contacting the blood Contact to avoid toxicity to blood.
在本实施方式中,所述外管壁11为聚乙烯涂层,所述内管壁12为尼龙聚四氟乙烯涂层。在工作过程中,先对半导体制冷片4的两条导线5通直流电,直到编织网的温度达到所要求的低温温度,将该状态下的指引导管经股动脉插入人体血管内,同时通入体外冷却的血液,保持直流电的电流恒定,以保证半导体制冷片4的制冷温度的恒定,由于铜的导热性能良好,能保持长时间的低温状态,当血液流经导管本体1后,人体温度将先传递给低温状态下的编织网,再传递给低温血液,从而保证血液流出时的温度比不加入编织网低温状态时流出的温度低。In this embodiment, the outer tube wall 11 is coated with polyethylene, and the inner tube wall 12 is coated with nylon polytetrafluoroethylene. During the working process, first pass direct current to the two wires 5 of the semiconductor refrigeration sheet 4 until the temperature of the braided mesh reaches the required low temperature, then insert the guiding catheter in this state into the blood vessel of the human body through the femoral artery, and at the same time pass it into the body The cooled blood keeps the current of the direct current constant to ensure the constant cooling temperature of the semiconductor refrigerating sheet 4. Due to the good thermal conductivity of copper, it can maintain a low temperature state for a long time. When the blood flows through the catheter body 1, the temperature of the human body will first It is passed to the braided mesh in a low-temperature state, and then passed to the low-temperature blood, so as to ensure that the temperature of the blood flowing out is lower than that of the low-temperature state without the braided mesh.
对于降温部件2还可以将铜丝的技术方案和编织网的技术方案结合,即降温部件2同时包括铜丝和编织网,铜丝的设置方式和编织网的设置方案按照上文记载的方案实施,铜丝和编织网均与所述导热板3连接,这种方案可以进一步加快冷却速度。当然,本领域技术人员为了节约成本,可以选择仅设置铜丝的方案或者仅设置编织网的方案,只要能够达到所要的冷却效果即可。For the cooling component 2, the technical solution of the copper wire and the braided net can also be combined, that is, the cooling component 2 includes both the copper wire and the braided net, and the arrangement of the copper wire and the braided net are implemented according to the above-mentioned scheme. , the copper wire and the braided mesh are all connected to the heat conducting plate 3, and this scheme can further accelerate the cooling speed. Of course, in order to save costs, those skilled in the art can choose the solution of only providing copper wires or only woven mesh, as long as the desired cooling effect can be achieved.
最后应说明的是:以上实施例仅用以说明本发明的技术方案,而非对其限制;尽管参照前述实施例对本发明进行了详细的说明,本领域的普通技术人员应当理解:其依然可以对前述各实施例所记载的技术方案进行修改,或者对其中部分技术特征进行等同替换;而这些修改或者替换,并不使相应技术方案的本质脱离本发明各实施例技术方案的精神和范围。Finally, it should be noted that: the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit them; although the present invention has been described in detail with reference to the foregoing embodiments, those of ordinary skill in the art should understand that: it can still be Modifications are made to the technical solutions described in the foregoing embodiments, or equivalent replacements are made to some of the technical features; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the spirit and scope of the technical solutions of the various embodiments of the present invention.
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