CN110075049B - Traditional Chinese medicine extract and preparation method and application thereof - Google Patents
Traditional Chinese medicine extract and preparation method and application thereof Download PDFInfo
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- CN110075049B CN110075049B CN201910492526.9A CN201910492526A CN110075049B CN 110075049 B CN110075049 B CN 110075049B CN 201910492526 A CN201910492526 A CN 201910492526A CN 110075049 B CN110075049 B CN 110075049B
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- 229940045885 sodium lauroyl sarcosinate Drugs 0.000 description 1
- GOJYXPWOUJYXJC-UHFFFAOYSA-M sodium;2-[1-(2-hydroxyethyl)-2-undecyl-4,5-dihydroimidazol-1-ium-1-yl]acetate;hydroxide Chemical compound [OH-].[Na+].CCCCCCCCCCCC1=NCC[N+]1(CCO)CC([O-])=O GOJYXPWOUJYXJC-UHFFFAOYSA-M 0.000 description 1
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Abstract
The invention relates to a traditional Chinese medicine extract and a preparation method and application thereof, wherein the preparation raw materials of the traditional Chinese medicine extract comprise the following components in percentage by mass: 0.1 to 60 percent of white mulberry root-bark, 0.1 to 60 percent of ginger root, 0.1 to 60 percent of cacumen biotae, 0.1 to 60 percent of liquorice and 0.1 to 60 percent of Chinese magnoliavine fruit; the preparation method comprises the following steps: (1) pretreatment: respectively crushing the cortex mori radicis, the ginger root, the cacumen biotae, the liquorice and the schisandra chinensis according to the formula ratio into powder, and mixing to obtain mixed powder; (2) extraction: adding an extraction solvent into the mixed powder, soaking, separating, and concentrating to obtain a concentrated solution, thereby obtaining the traditional Chinese medicine extract. The traditional Chinese medicine extract provided by the invention can improve the activity of hair and scalp cells, improve the blood circulation of the head, fix hair roots, prevent alopecia and has a hair growth effect, and the traditional Chinese medicine extract has anti-inflammatory and antibacterial effects, is safe and has no side effect.
Description
Technical Field
The invention relates to the field of daily chemicals, in particular to a traditional Chinese medicine extract and a preparation method and application thereof, and especially relates to a traditional Chinese medicine extract with anti-hair loss and hair growth effects and a preparation method and application thereof.
Background
The hair is an accessory organ of the skin, has certain functions of defense and body temperature maintenance, is more important as a second characteristic of a human body, has strong modification function, has plasticity, selectivity and decorativeness, and is more important for the coordination of the head, the face, the shoulders and the neck and the whole body state. Everyone wants to keep a large amount of hair as long as possible, and above all, to avoid hair loss. From age 35, about 40% of men develop significant hair loss, while 60 years old women have as high as 80% hair loss. The most obvious cause of hair loss is aging, which results in atrophy of hair follicles and a shortened hair growth cycle. Alopecia can also result from factors such as stress, hormonal changes, genetics, malnutrition, and the like.
At present, hair washing products for preventing hair loss on the market are uneven, and have little and less hair loss prevention effect. In medicine, the common methods for treating alopecia are divided into external application and internal application. The external medicine mainly comprises minoxidil, cyclosporin A and the like, but has certain side effects on the body, and relapse can occur after drug withdrawal. The oral medicine is mainly antiandrogen preparation, such as finasteride, cyproterone, etc., and the oral antiandrogen preparation can improve curative effect, but can reduce the level of dihydrotestosterone in serum and scalp, so that the sexual desire is reduced, and the oral medicine has teratogenesis effect, and can not be used for children and women of childbearing age.
CN109316427A discloses a plant anti-hair loss shampoo, which comprises the following components: 2 parts of sorbitol, 2 parts of polyoxyethylene polyethylene glycol, 10 parts of ethanol, 1 part of polyoxyethylene oleate, 4 parts of aloe extract, 1 part of polyglutamic acid, 2 parts of butanediol, 5 parts of coconut oil fatty acid diethanolamide, 1 part of erucic acid, 3 parts of glycerol, 1 part of preservative, 10 parts of triethanolamine and 58 parts of deionized water. The shampoo also comprises ramulus Cinnamomi and flos Lonicerae. The shampoo can clean hair and scalp, prevent hair loss and dredge blood collaterals, but the hair growth and loss prevention effects need to be improved.
CN109718143A discloses an anti-hair loss shampoo, which comprises the following substances in parts by weight: 100 parts of water, 10-15 parts of amino acid foaming agent, 51-5 parts of vitamin B, 1-3 parts of vitamin E, 5-10 parts of NaCl, 3-8 parts of glycerol, 5-8 parts of rosemary extract, 6-8 parts of hyaluronic acid, 3-6 parts of sweet almond oil, 3-10 parts of lavender essential oil, 1-5 parts of grape seed extract and 1-5 parts of avocado extract. The anti-hair loss shampoo provided by the invention is natural in components, is suitable for sensitive people, can effectively protect hair quality from being damaged, nourish hair roots and prevent hair from falling off easily, so that the shampoo only can play a role in protecting and nourishing the hair, cannot radically solve the problem of hair loss, and has an unobvious effect.
CN1608609A discloses an external cosmetic and a preparation method thereof, in particular to a quick-acting hair restorer and a preparation method thereof. The quick-acting hair restorer is prepared from cortex Albizziae, flos Rosae chinensis, rhizoma Helminthostachydis Zeylanicae, rhizoma Atractylodis, fructus Schisandrae chinensis, Carthami flos, rhizoma Ligustici Chuanxiong, radix Codonopsis, radix Angelicae Dahuricae, rhizoma Gastrodiae, radix rehmanniae Preparata, radix Paeoniae alba, radix Angelicae sinensis, Notopterygii rhizoma, Zingiberis rhizoma, semen Sojae Atricolor, Camphora, Borneolum Syntheticum, and Minoxidil by pulverizing, dissolving in ethanol (75% sterile alcohol), and filtering. The hair-growing shampoo is mainly used for treating alopecia areata, alopecia totalis, alopecia universalis, seborrheic alopecia, neurogenic alopecia, hereditary alopecia, alopecia after chemotherapy, alopecia premature alopecia and other alopecia symptoms, has the hair-growing effect, has the hair-fixing effect on various excessive alopecia, seasonal alopecia, postpartum alopecia, hair combing, washing, hair loss and the like, has the hair-blackening effect on premature gray hair and white hair of middle-aged and old people, has the effects of diminishing inflammation, relieving pain, treating tinea capitis dermatitis, removing dandruff, relieving itching and has the remarkable effects of preventing hair from drying, splitting hair tips and splitting hair. However, the cosmetic preparation containing minoxidil may cause side effects, and the recurrence is likely to occur after the withdrawal of the preparation.
Therefore, the development of a novel product which has obvious effects of preventing alopecia and promoting hair growth, is safe and has no side effect is urgently needed in the field.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine extract, a preparation method and application thereof, in particular to a traditional Chinese medicine extract with the effects of preventing alopecia and promoting hair growth, a preparation method and application thereof, and the traditional Chinese medicine extract is safe and has no side effect.
In order to achieve the purpose, the invention adopts the following technical scheme:
the invention provides a traditional Chinese medicine extract, which is prepared from the following raw materials in percentage by mass: 0.1 to 60 percent of white mulberry root-bark, 0.1 to 60 percent of ginger root, 0.1 to 60 percent of cacumen biotae, 0.1 to 60 percent of liquorice and 0.1 to 60 percent of schisandra chinensis.
The mass percentage of the cortex mori radicis may be 0.2%, 1%, 2%, 3%, 4%, 5%, 6%, 8%, 10%, 11%, 12%, 13%, 15%, 18%, 19%, 20%, 22%, 23%, 24%, 25%, 28%, 30%, 31%, 33%, 35%, 36%, 38%, 40%, 42%, 43%, 45%, 46%, 48%, 50%, 51%, 54%, 55%, 57%, 58%, 59%, etc.
The ginger root may be 0.2%, 1%, 2%, 3%, 4%, 5%, 6%, 8%, 10%, 11%, 12%, 13%, 15%, 18%, 19%, 20%, 22%, 23%, 24%, 25%, 28%, 30%, 31%, 33%, 35%, 36%, 38%, 40%, 42%, 43%, 45%, 46%, 48%, 50%, 51%, 54%, 55%, 57%, 58%, 59% by mass or the like.
The mass percentage of the cacumen biotae may be 0.2%, 1%, 2%, 3%, 4%, 5%, 6%, 8%, 10%, 11%, 12%, 13%, 15%, 18%, 19%, 20%, 22%, 23%, 24%, 25%, 28%, 30%, 31%, 33%, 35%, 36%, 38%, 40%, 42%, 43%, 45%, 46%, 48%, 50%, 51%, 54%, 55%, 57%, 58%, 59%, etc.
The licorice may be present in an amount of 0.2%, 1%, 2%, 3%, 4%, 5%, 6%, 8%, 10%, 11%, 12%, 13%, 15%, 18%, 19%, 20%, 22%, 23%, 24%, 25%, 28%, 30%, 31%, 33%, 35%, 36%, 38%, 40%, 42%, 43%, 45%, 46%, 48%, 50%, 51%, 54%, 55%, 57%, 58%, 59%, etc.
The mass percentage of the schisandra fruit can be 0.2%, 1%, 2%, 3%, 4%, 5%, 6%, 8%, 10%, 11%, 12%, 13%, 15%, 18%, 19%, 20%, 22%, 23%, 24%, 25%, 28%, 30%, 31%, 33%, 35%, 36%, 38%, 40%, 42%, 43%, 45%, 46%, 48%, 50%, 51%, 54%, 55%, 57%, 58%, 59% and the like.
The traditional Chinese medicine extract provided by the invention has the following effects in the preparation raw materials:
white mulberry root-bark: is cold in nature and sweet in taste, can purge lung and relieve asthma, induce diuresis and reduce edema when being taken orally, can treat 'falling hair, lusterless hair when being taken externally', and has the efficacies of reducing blood pressure, resisting inflammation, resisting bacteria and the like.
Ginger root: the extract contains active ingredients such as gingerol and shogae oil, and has effects of dispelling cold, inducing perspiration, eliminating phlegm, relieving cough, regulating stomach function, relieving vomit, treating skin edema, and invigorating spleen and stomach.
Cacumen biotae: bitter, astringent and cold in property, and has the effects of cooling blood, stopping bleeding, reducing phlegm, relieving cough, promoting hair growth, blackening hair and the like. Record of the food taboo of the grandson: the hair is not growing, and the cacumen biotae is dried in the shade and made into powder, and is coated with sesame oil.
Licorice root: the licorice extract contains multiple chemical components, wherein glycyrrhizic acid has the effects of resisting inflammation, whitening and nourishing hair.
Schisandra chinensis: the extract contains schizandrin, vitamin C, etc., and has effects of astringing lung, relieving cough, nourishing, arresting seminal emission, relieving diarrhea, and arresting sweating.
The five traditional Chinese medicines are compounded according to a certain proportion and then extracted to obtain a traditional Chinese medicine extract, and according to the principle of monarch, minister, assistant and guide, the active ingredients in the traditional Chinese medicine extract in a specific proportion have a synergistic effect, so that the activity of hair and scalp cells can be improved, the blood circulation of the head can be improved, the hair roots can be firmed, the alopecia can be prevented, the hair growth effect can be realized, and the anti-inflammatory and antibacterial effects can be realized; meanwhile, the Chinese herbal medicine has mild and safe sources, and adverse reactions such as skin itch and contact allergy can not occur.
Preferably, the preparation raw materials of the traditional Chinese medicine extract comprise the following components in percentage by mass: 1-50% of white mulberry root-bark, 1-50% of ginger root, 1-50% of cacumen biotae, 1-50% of licorice and 1-50% of schisandra fruit.
The formula is further optimized, five components with specific contents are selected, the active ingredients are better compatible, and the anti-hair loss and hair growth effects of the traditional Chinese medicine composition are further improved.
Preferably, the preparation raw materials of the traditional Chinese medicine extract comprise the following components in percentage by mass: 30% of cortex mori, 20% of ginger root, 20% of cacumen biotae, 10% of liquorice and 20% of schisandra chinensis.
Preferably, the preparation raw materials of the traditional Chinese medicine extract comprise the following components in percentage by mass: 50% of cortex mori, 10% of ginger root, 10% of cacumen biotae, 10% of liquorice and 20% of schisandra chinensis.
Preferably, the preparation raw materials of the traditional Chinese medicine extract comprise the following components in percentage by mass: 5% of cortex mori, 10% of ginger root, 40% of cacumen biotae, 15% of liquorice and 30% of schisandra chinensis.
Preferably, the preparation raw materials of the traditional Chinese medicine extract comprise the following components in percentage by mass: 15% of cortex mori, 25% of ginger root, 25% of cacumen biotae, 25% of liquorice and 10% of schisandra chinensis.
Preferably, the preparation raw materials of the traditional Chinese medicine extract comprise the following components in percentage by mass: 5% of cortex mori, 30% of ginger root, 20% of cacumen biotae, 30% of liquorice and 15% of schisandra chinensis.
The second purpose of the invention is to provide a preparation method of the traditional Chinese medicine extract, which is characterized by comprising the following steps:
(1) pretreatment: respectively crushing the cortex mori radicis, the ginger root, the cacumen biotae, the liquorice and the schisandra chinensis according to the formula ratio into powder, and mixing to obtain mixed powder;
(2) extraction: adding an extraction solvent into the mixed powder, soaking, separating, and concentrating to obtain a concentrated solution, thereby obtaining the traditional Chinese medicine extract.
Preferably, the particle size of the powder is 100-500 mesh.
Preferably, in step (2), the extraction solvent comprises water and/or ethanol.
Preferably, in step (2), the mass ratio of the extraction solvent to the mixed powder is 1:1-40:1, such as 2:1, 3:1, 4:1, 5:1, 8:1, 10:1, 12:1, 15:1, 16:1, 18:1, 19:1, 20:1, 22:1, 25:1, 26:1, 28:1, 30:1, 31:1, 32:1, 33:1, 34:1, 35:1, 36:1, 37:1, 38:1, 39:1, and the like.
Preferably, in step (2), the soaking time is 1-5h, such as 1.1h, 1.2h, 1.3h, 1.5h, 1.6h, 1.8h, 2.0h, 2.2h, 2.3h, 2.5h, 2.7h, 2.8h, 2.9h, 3.0h, 3.2h, 3.5h, 3.8h, 4.0h, 4.1h, 4.2h, 4.3h, 4.5h, 4.7h, 4.8h, 4.9h and the like.
Preferably, in step (2), the soaking is performed in a water bath, preferably at a temperature of 40-90 deg.C, such as 41 deg.C, 42 deg.C, 43 deg.C, 44 deg.C, 45 deg.C, 46 deg.C, 48 deg.C, 50 deg.C, 52 deg.C, 55 deg.C, 56 deg.C, 57 deg.C, 58 deg.C, 59 deg.C, 60 deg.C, 62 deg.C, 63 deg.C, 64 deg.C, 67 deg.C, 68 deg.C, 69 deg.C, 70 deg.C, 72 deg.C, 75 deg.C, 78 deg.C, 80 deg.C, 82 deg.C, 85 deg.C, 86 deg.C, 87 deg.C, 88 deg.C, 89 deg.C.
Preferably, in step (2), the method of separating comprises centrifugation.
Preferably, step (3) is performed after step (2): and (3) purifying the concentrated solution obtained in the step (2), and then concentrating and filtering to obtain the traditional Chinese medicine extract.
Preferably, in step (3), the purification method comprises purification using a macroporous resin.
Preferably, the macroporous resin has a particle size of 20-50 mesh.
Preferably, the macroporous resin comprises any one or a combination of at least two of AB-8, D1300 and D101.
Preferably, in step (2) and step (3), the method of concentration comprises rotary evaporation.
Preferably, the preparation method specifically comprises the following steps:
(1) pretreatment: respectively crushing the cortex mori radicis, the ginger root, the cacumen biotae, the liquorice and the schisandra chinensis according to the formula ratio into 500-mesh powder with the granularity of 100 meshes, and mixing to obtain mixed powder;
(2) extraction: adding an extraction solvent into the mixed powder according to the mass ratio of the extraction solvent to the mixed powder of 1:1-40:1, soaking in a water bath kettle at 40-90 ℃ for 1-5 hours, and performing centrifugal separation and rotary evaporation to obtain a concentrated solution;
(3) and (3) purification: purifying the concentrated solution by using macroporous resin with the granularity of 20-50 meshes, and then performing rotary evaporation and filtration to obtain the traditional Chinese medicine extract.
The invention also aims to provide a washing and caring product, which contains the traditional Chinese medicine extract.
Preferably, the traditional Chinese medicine extract accounts for 0.1-80% of the washing and caring product by mass, such as 0.2%, 0.5%, 0.8%, 1.0%, 2%, 5%, 7%, 9%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 78%, 79% and the like, preferably 1-50%, and more preferably 5-40%.
Preferably, the wash care product comprises a shampoo, a hair spray, a leave-on hair conditioner, a conditioner or a hair mask.
Compared with the prior art, the invention has the following beneficial effects:
the traditional Chinese medicine extract provided by the invention can improve the activity of hair and scalp cells, improve the blood circulation of the head, fix hair roots, prevent alopecia, has a hair growth effect, and has anti-inflammatory and antibacterial effects; meanwhile, the Chinese herbal medicine has mild and safe sources, and adverse reactions such as skin itch and contact allergy can not occur.
Detailed Description
The technical solution of the present invention is further explained by the following embodiments. It should be understood by those skilled in the art that the examples are only for the understanding of the present invention and should not be construed as the specific limitations of the present invention.
Example 1 preparation of Chinese medicine extract (1)
The preparation raw materials of the traditional Chinese medicine extract provided by the embodiment comprise the following components in percentage by mass: 30% of cortex mori, 20% of ginger root, 20% of cacumen biotae, 10% of liquorice and 20% of schisandra chinensis.
The preparation method comprises the following steps:
(1) pretreatment: respectively crushing the cortex mori radicis, the ginger root, the cacumen biotae, the liquorice and the schisandra chinensis according to the formula ratio into powder with the granularity of 200 meshes, and mixing to obtain mixed powder;
(2) extraction: adding water (the mass ratio of water to the mixed powder is 30:1) into the mixed powder, soaking for 4 hours in a water bath kettle at 80 ℃, and obtaining a concentrated solution after centrifugal separation and rotary evaporation;
(3) and (3) purification: and purifying the concentrated solution by using AB-8 macroporous resin, and then performing rotary evaporation and filtration to obtain the traditional Chinese medicine extract.
Example 2 preparation of Chinese medicine extract (2)
The preparation raw materials of the traditional Chinese medicine extract provided by the embodiment comprise the following components in percentage by mass: 50% of cortex mori, 10% of ginger root, 10% of cacumen biotae, 10% of liquorice and 20% of schisandra chinensis.
The preparation method comprises the following steps:
(1) pretreatment: respectively crushing the cortex mori radicis, the ginger root, the cacumen biotae, the liquorice and the schisandra chinensis according to the formula ratio into powder with the granularity of 200 meshes, and mixing to obtain mixed powder;
(2) extraction: adding water (the mass ratio of water to the mixed powder is 10:1) into the mixed powder, soaking for 4 hours in a water bath kettle at 80 ℃, and obtaining a concentrated solution after centrifugal separation and rotary evaporation;
(3) and (3) purification: and purifying the concentrated solution by using AB-8 macroporous resin, and then performing rotary evaporation and filtration to obtain the traditional Chinese medicine extract.
Example 3 preparation of Chinese medicine extract (3)
The preparation raw materials of the traditional Chinese medicine extract provided by the embodiment comprise the following components in percentage by mass: 5% of cortex mori, 10% of ginger root, 40% of cacumen biotae, 15% of liquorice and 30% of schisandra chinensis.
The preparation method comprises the following steps:
(1) pretreatment: respectively crushing the cortex mori radicis, the ginger root, the cacumen biotae, the liquorice and the schisandra chinensis according to the formula ratio into powder with the granularity of 300 meshes, and mixing to obtain mixed powder;
(2) extraction: adding water (the mass ratio of water to the mixed powder is 20:1) into the mixed powder, soaking for 5 hours in a water bath kettle at 45 ℃, and obtaining a concentrated solution after centrifugal separation and rotary evaporation;
(3) and (3) purification: and purifying the concentrated solution by using D101 macroporous resin, and then performing rotary evaporation and filtration to obtain the traditional Chinese medicine extract.
Example 4 preparation of Chinese medicine extract (4)
The preparation raw materials of the traditional Chinese medicine extract provided by the embodiment comprise the following components in percentage by mass: 15% of cortex mori, 25% of ginger root, 25% of cacumen biotae, 25% of liquorice and 10% of schisandra chinensis.
The preparation method comprises the following steps:
(1) pretreatment: respectively crushing the cortex mori radicis, the ginger root, the cacumen biotae, the liquorice and the schisandra chinensis according to the formula ratio into powder with the granularity of 200 meshes, and mixing to obtain mixed powder;
(2) extraction: adding water (the mass ratio of water to the mixed powder is 30:1) into the mixed powder, soaking in a water bath kettle at 50 ℃ for 5 hours, and performing centrifugal separation and rotary evaporation to obtain a concentrated solution;
(3) and (3) purification: and purifying the concentrated solution by using AB-8 macroporous resin, and then performing rotary evaporation and filtration to obtain the traditional Chinese medicine extract.
Example 5 preparation of Chinese medicine extract (5)
The preparation raw materials of the traditional Chinese medicine extract provided by the embodiment comprise the following components in percentage by mass: 5% of cortex mori, 30% of ginger root, 20% of cacumen biotae, 30% of liquorice and 15% of schisandra chinensis.
The preparation method comprises the following steps:
(1) pretreatment: respectively crushing the cortex mori radicis, the ginger root, the cacumen biotae, the liquorice and the schisandra chinensis according to the formula ratio into powder with the granularity of 150 meshes, and mixing to obtain mixed powder;
(2) extraction: adding water (the mass ratio of water to the mixed powder is 40:1) into the mixed powder, soaking in a water bath kettle at 85 ℃ for 2 hours, and performing centrifugal separation and rotary evaporation to obtain a concentrated solution;
(3) and (3) purification: and purifying the concentrated solution by using D1300 macroporous resin, and then performing rotary evaporation and filtration to obtain the traditional Chinese medicine extract.
Example 6 preparation of Chinese medicine extract (6)
The difference from the embodiment 1 is that the preparation raw materials of the traditional Chinese medicine extract comprise the following components in percentage by mass: cortex Mori 50%, rhizoma Zingiberis recens 1%, folium Platycladi 1%, Glycyrrhrizae radix 1%, and fructus Schisandrae 47%
Example 7 preparation of Chinese medicine extract (7)
The difference from the embodiment 1 is that the preparation raw materials of the traditional Chinese medicine extract comprise the following components in percentage by mass: 1% of cortex mori, 50% of ginger root, 32% of cacumen biotae, 16% of liquorice and 1% of schisandra chinensis.
Example 8 preparation of Chinese medicine extract (8)
The difference from the embodiment 1 is that the preparation raw materials of the traditional Chinese medicine extract comprise the following components in percentage by mass: 22% of cortex mori, 8% of ginger root, 50% of cacumen biotae, 11% of liquorice and 9% of schisandra chinensis.
Example 9 preparation of Chinese medicine extract (9)
The difference from the embodiment 1 is that the preparation raw materials of the traditional Chinese medicine extract comprise the following components in percentage by mass: 20% of cortex mori, 10% of ginger root, 10% of cacumen biotae, 50% of liquorice and 10% of schisandra chinensis.
Example 10 preparation of Chinese medicine extract (10)
The difference from the embodiment 1 is that the preparation raw materials of the traditional Chinese medicine extract comprise the following components in percentage by mass: 20% of cortex mori, 10% of ginger root, 10% of cacumen biotae, 10% of liquorice and 50% of schisandra chinensis.
EXAMPLE 11 preparation of herbal extract (11)
The difference from the embodiment 1 is that the preparation raw materials of the traditional Chinese medicine extract comprise the following components in percentage by mass: 60% of cortex mori, 0.1% of ginger root, 0.1% of cacumen biotae, 0.1% of liquorice and 39.7% of schisandra chinensis.
EXAMPLE 12 preparation of herbal extract (12)
The difference from the embodiment 1 is that the preparation raw materials of the traditional Chinese medicine extract comprise the following components in percentage by mass: 0.1% of cortex mori, 60% of ginger root, 16% of cacumen biotae, 7.9% of liquorice and 16% of schisandra chinensis.
EXAMPLE 13 preparation of herbal extract (13)
The difference from the embodiment 1 is that the preparation raw materials of the traditional Chinese medicine extract comprise the following components in percentage by mass: 19.9 percent of white mulberry root-bark, 10 percent of ginger root, 60 percent of cacumen biotae, 10 percent of liquorice and 0.1 percent of schisandra chinensis.
EXAMPLE 14 preparation of herbal extract (14)
The difference from the embodiment 1 is that the preparation raw materials of the traditional Chinese medicine extract comprise the following components in percentage by mass: 10% of cortex mori, 10% of ginger root, 10% of cacumen biotae, 60% of liquorice and 10% of schisandra chinensis.
EXAMPLE 15 preparation of herbal extract (15)
The difference from the embodiment 1 is that the preparation raw materials of the traditional Chinese medicine extract comprise the following components in percentage by mass: 15% of cortex mori, 10% of ginger root, 10% of cacumen biotae, 5% of liquorice and 60% of schisandra chinensis.
EXAMPLE 16 preparation of herbal extract (16)
The difference from example 1 is that the specific preparation method is as follows:
(1) pretreatment: respectively crushing the cortex mori radicis, the ginger root, the cacumen biotae, the liquorice and the schisandra chinensis according to the formula ratio into powder with the granularity of 100 meshes, and mixing to obtain mixed powder;
(2) extraction: adding ethanol (the mass ratio of the ethanol to the mixed powder is 1:1) into the mixed powder, soaking in a water bath kettle at 40 ℃ for 5 hours, and performing centrifugal separation and rotary evaporation to obtain a concentrated solution;
(3) and (3) purification: and purifying the concentrated solution by using D1300 macroporous resin, and then performing rotary evaporation and filtration to obtain the traditional Chinese medicine extract.
EXAMPLE 17 preparation of herbal extract (17)
The difference from example 1 is that the specific preparation method is as follows:
(1) pretreatment: respectively crushing the cortex mori radicis, the ginger root, the cacumen biotae, the liquorice and the schisandra chinensis according to the formula ratio into powder with the granularity of 500 meshes, and mixing to obtain mixed powder;
(2) extraction: adding the mixture into the mixed powder according to the mass ratio of 10: 7 soaking a water/ethanol mixture (the mass ratio of the water/ethanol mixture to the mixed powder is 30:1) in a water bath kettle at 90 ℃ for 1 hour, and performing centrifugal separation and rotary evaporation to obtain a concentrated solution;
(3) and (3) purification: purifying the concentrated solution by using AB-8 macroporous resin, and then performing rotary evaporation and filtration to obtain the traditional Chinese medicine extract.
Comparative example 1 preparation of Chinese medicine extract (D1)
The difference from the embodiment 1 is that the preparation raw materials of the traditional Chinese medicine extract comprise the following components in percentage by mass: 100 percent of cortex mori radicis.
Comparative example 2 preparation of Chinese medicine extract (D2)
The difference from the embodiment 1 is that the preparation raw materials of the traditional Chinese medicine extract comprise the following components in percentage by mass: 100 percent of ginger root.
Comparative example 3 preparation of Chinese medicine extract (D3)
The difference from the embodiment 1 is that the preparation raw materials of the traditional Chinese medicine extract comprise the following components in percentage by mass: 100 percent of cacumen biotae.
Comparative example 4 preparation of Chinese medicine extract (D4)
The difference from the embodiment 1 is that the preparation raw materials of the traditional Chinese medicine extract comprise the following components in percentage by mass: 100 percent of liquorice.
Comparative example 5 preparation of Chinese medicine extract (D5)
The difference from the embodiment 1 is that the preparation raw materials of the traditional Chinese medicine extract comprise the following components in percentage by mass: 100 percent of schisandra chinensis.
Comparative example 6 preparation of Chinese medicine extract (D6)
The difference from the embodiment 1 is that the preparation raw materials of the traditional Chinese medicine extract comprise the following components in percentage by mass: 28.6 percent of ginger root, 28.6 percent of cacumen biotae, 14.2 percent of liquorice and 28.6 percent of schisandra chinensis.
Comparative example 7 preparation of Chinese medicine extract (D7)
The difference from the embodiment 1 is that the preparation raw materials of the traditional Chinese medicine extract comprise the following components in percentage by mass: 37.5 percent of white mulberry root-bark, 25 percent of cacumen biotae, 12.5 percent of liquorice and 25 percent of schisandra chinensis.
Comparative example 8 preparation of Chinese medicine extract (D8)
The difference from the embodiment 1 is that the preparation raw materials of the traditional Chinese medicine extract comprise the following components in percentage by mass: 37.5 percent of white mulberry root-bark, 25 percent of ginger root, 12.5 percent of liquorice and 25 percent of Chinese magnoliavine fruit.
Comparative example 9 preparation of Chinese medicine extract (D9)
The difference from the embodiment 1 is that the preparation raw materials of the traditional Chinese medicine extract comprise the following components in percentage by mass: 30% of cortex mori, 20% of ginger root, 20% of cacumen biotae and 20% of schisandra chinensis.
Comparative example 10 preparation of Chinese medicine extract (D10)
The difference from the embodiment 1 is that the preparation raw materials of the traditional Chinese medicine extract comprise the following components in percentage by mass: 33.4 percent of white mulberry root-bark, 22.2 percent of ginger root, 22.2 percent of cacumen biotae and 22.2 percent of liquorice.
Application example 1
The application example provides anti-hair loss shampoo which comprises the following components in percentage by mass:
the preparation method of the anti-hair loss shampoo comprises the following steps:
(1) putting water, sodium laureth sulfate, cocamidopropyl betaine, polyquaternium-10, sodium citrate, citric acid, disodium EDTA, sodium benzoate and ethylene glycol distearate into a container, stirring and heating to 85 ℃, and stirring and dissolving until the mixture is transparent to obtain a mixed solution A;
(2) cooling the mixed solution A to 45 deg.C, adding the Chinese medicinal extract (1), essence, phenoxyethanol, and water, and mixing.
Application example 2
The difference from application example 1 is that the traditional Chinese medicine extract (1) is replaced by the traditional Chinese medicine extract (2) with equal mass.
Application example 3
The difference from application example 1 is that the traditional Chinese medicine extract (1) is replaced by the traditional Chinese medicine extract (3) with equal mass.
Application example 4
The difference from application example 1 is that the traditional Chinese medicine extract (1) is replaced by the traditional Chinese medicine extract (4) with equal mass.
Application example 5
The difference from application example 1 is that the traditional Chinese medicine extract (1) is replaced by the traditional Chinese medicine extract (5) with equal mass.
Application example 6
The difference from application example 1 is that the traditional Chinese medicine extract (1) is replaced by the traditional Chinese medicine extract (6) with equal mass.
Application example 7
The difference from application example 1 is that the traditional Chinese medicine extract (1) is replaced by the traditional Chinese medicine extract (7) with equal mass.
Application example 8
The difference from application example 1 is that the traditional Chinese medicine extract (1) is replaced by the traditional Chinese medicine extract (8) with equal mass.
Application example 9
The difference from application example 1 is that the traditional Chinese medicine extract (1) is replaced by the traditional Chinese medicine extract (9) with equal mass.
Application example 10
The difference from the application example 1 is that the traditional Chinese medicine extract (1) is replaced by the traditional Chinese medicine extract (10) with equal mass.
Application example 11
The difference from application example 1 is that the traditional Chinese medicine extract (1) is replaced by the traditional Chinese medicine extract (11) with equal mass.
Application example 12
The difference from application example 1 is that the traditional Chinese medicine extract (1) is replaced by the traditional Chinese medicine extract (12) with equal mass.
Application example 13
The difference from application example 1 is that the traditional Chinese medicine extract (1) is replaced by the traditional Chinese medicine extract (13) with equal mass.
Application example 14
The difference from the application example 1 is that the traditional Chinese medicine extract (1) is replaced by the traditional Chinese medicine extract (14) with equal mass.
Application example 15
The difference from application example 1 is that the traditional Chinese medicine extract (1) is replaced by the traditional Chinese medicine extract (15) with equal mass.
Application example 16
The difference from the application example 1 is that the traditional Chinese medicine extract (1) is replaced by the traditional Chinese medicine extract (16) with equal mass.
Application example 17
The difference from application example 1 is that the traditional Chinese medicine extract (1) is replaced by the traditional Chinese medicine extract (17) with equal mass.
Application example 18
The application example provides anti-hair loss shampoo which comprises the following components in percentage by mass:
the preparation method comprises the following steps:
(1) putting water, ammonium laureth sulfate, sodium lauroamphoacetate, guar hydroxypropyltrimonium chloride, acrylic acid (ester)/C10-30 alkanol acrylate cross-linked polymer, disodium EDTA and ethylene glycol distearate into a container, homogenizing, stirring and heating to 85 ℃, stirring and dissolving to be transparent, and adjusting the pH value to 6.5 by using sodium hydroxide to obtain a mixed solution A;
(2) cooling the mixed solution A to 45 deg.C, adding the Chinese medicinal extract (1), essence, and Kathon, adding water, adjusting pH to 6.0 with citric acid, and mixing.
Application example 19
The application example provides anti-hair loss shampoo which comprises the following components in percentage by mass:
the preparation method comprises the following steps:
(1) putting water, sodium laureth sulfate, cocamidopropyl betaine, polyquaternium-10, sodium citrate, citric acid, disodium EDTA, sodium benzoate and ethylene glycol distearate into a container, stirring and heating to 85 ℃, and stirring and dissolving until the mixture is transparent to obtain a mixed solution A;
(2) cooling the mixed solution A to 45 deg.C, adding the Chinese medicinal extract (3), essence, phenoxyethanol, and water, and mixing.
Application example 20
The application example provides anti-hair loss shampoo which comprises the following components in percentage by mass:
the preparation method comprises the following steps:
(1) putting water, sodium lauroyl sarcosinate, sodium lauroyl amphoacetate, cocamidopropyl betaine, polyquaternium-10, sodium citrate, citric acid, EDTA disodium, sodium benzoate and glycerol laurate into a container, stirring and heating to 85 ℃, and stirring and dissolving until the mixture is transparent to obtain a mixed solution A;
(2) cooling the mixed solution A to 45 deg.C, adding Chinese medicinal extract (5), essence, phenoxyethanol, and water, and mixing.
Application example 21
The application example provides a washing-free anti-dropping essence which comprises the following components in percentage by mass:
wherein the acrylic acid (ester) copolymer is acrylic acid (ester)/C10-30 alkanol acrylate crosslinked polymer.
The preparation method comprises the following steps:
(1) slowly spreading acrylic acid (ester)/C10-30 alkanol acrylate crosslinked polymer into cold deionized water, completely swelling, homogenizing, heating to 80 deg.C, adding nicotinamide, and dissolving completely;
(2) cooling to 45 deg.C, sequentially adding Chinese medicinal extract (4), glycerol, ethanol, phenoxyethanol, and essence;
(3) adjusting pH to 5.5 with sodium hydroxide solution, and stirring.
Comparative application example 1
The difference from application example 1 is that the traditional Chinese medicine extract (1) is replaced by the traditional Chinese medicine extract (D1) with equal mass.
Comparative application example 2
The difference from application example 1 is that the traditional Chinese medicine extract (1) is replaced by the traditional Chinese medicine extract (D2) with equal mass.
Comparative application example 3
The difference from application example 1 is that the traditional Chinese medicine extract (1) is replaced by the traditional Chinese medicine extract (D3) with equal mass.
Comparative application example 4
The difference from application example 1 is that the traditional Chinese medicine extract (1) is replaced by the traditional Chinese medicine extract (D4) with equal mass.
Comparative application example 5
The difference from application example 1 is that the traditional Chinese medicine extract (1) is replaced by the traditional Chinese medicine extract (D5) with equal mass.
Comparative application example 6
The difference from application example 1 is that the traditional Chinese medicine extract (1) is replaced by the traditional Chinese medicine extract (D6) with equal mass.
Comparative application example 7
The difference from application example 1 is that the traditional Chinese medicine extract (1) is replaced by the traditional Chinese medicine extract (D7) with equal mass.
Comparative application example 8
The difference from application example 1 is that the traditional Chinese medicine extract (1) is replaced by the traditional Chinese medicine extract (D8) with equal mass.
Comparative application example 9
The difference from application example 1 is that the traditional Chinese medicine extract (1) is replaced by the traditional Chinese medicine extract (D9) with equal mass.
Comparative application example 10
The difference from application example 1 is that the traditional Chinese medicine extract (1) is replaced by the traditional Chinese medicine extract (D10) with equal mass.
Comparative application example 11
The difference from application example 1 is that the traditional Chinese medicine extract (1) is not added, and water is used instead.
Comparative application example 12
The difference from application example 21 is that the Chinese medicinal extract (4) is not added, and is replaced by water.
Test example 1 evaluation of anti-separation Effect
1650 out-patient cases diagnosed with androgenetic alopecia were randomly selected and randomly and evenly divided into 33 groups of 50 patients each. The hair loss prevention shampoo of application examples 1 to 20, the hair loss prevention shampoo of comparative application examples 1 to 11, the leave-in hair loss prevention essence of application example 21, and the leave-in hair loss prevention essence of comparative application example 12 were used for 1 to 33 groups, respectively.
The application method of the shampoo comprises the following steps:
after the hair is fully wetted, the patient wipes the hair to be half-dry by using a towel, a proper amount of shampoo is smeared on the hair, the scalp is uniformly massaged for 5 minutes, the hair stays for 5 minutes, and then the hair is cleaned by warm water. The preparation is used once a day, and head photos are taken for three months. During the use of the product, other shampoo cannot be used, so that the effect is prevented from being influenced.
The using method of the essence comprises the following steps:
the patient smears the essence on the place with sparse hair, massages for 10 minutes until the essence is completely absorbed, uses the essence once in the morning and at night, takes pictures of the head of the patient and continuously uses the essence for three months.
The evaluation method comprises the following steps: the expert group evaluates the hair amount of the patient by comparing the pictures, and the hair amount is divided into three grades of cure (the hair amount is basically recovered to a normal state), effective (the hair amount is increased) and ineffective (the hair amount is unchanged), the number of people in each group with three grades is recorded, the percentage of the number of people in each grade to the total number of people in each group is calculated, and the cure rate, the effective rate and the ineffective rate are obtained. The specific evaluation results are shown in table 1.
TABLE 1
As can be seen from table 1, after three-month experiments, the cure rate and the effective rate of the application example group are significantly higher than those of the comparative application example group, which indicates that the anti-alopecia effect of the combination of five traditional Chinese medicines of cortex mori radicis, ginger root, cacumen biotae, liquorice, schisandra chinensis and the like according to a specific ratio is significantly better than that of the combination of one traditional Chinese medicine alone, four traditional Chinese medicines alone or no traditional Chinese medicine.
By comparing the data of application examples 1 and 6-15, it can be known that when the raw material formula of the traditional Chinese medicine extract meets the requirements of 1-50% of cortex mori, 1-50% of ginger root, 1-50% of cacumen biotae, 1-50% of liquorice and 1-50% of schisandra chinensis (application examples 1 and 6-10), the cure rate is higher, namely the traditional Chinese medicine extract has better anti-alopecia and hair growth effects.
Test example 2 erythrocyte hemolysis test (RBC test)
The erythrocyte hemolysis test is one of the alternatives of the rabbit eye irritation test (Draize test), and the basic principle is to evaluate the damage of chemicals to eye tissue cells by measuring the dissolution amount and denaturation degree of hemoglobin. The RBC test is used internationally for evaluating eye irritation studies on chemicals such as cosmetics and raw materials.
The products of application examples 1-21 were subjected to a red blood cell hemolysis experiment according to the RBC test protocol and grading standards of the European Alternatives validation center (ECVAM). ECVAM. ECVAM DB-ALM INVITOX Protoco, Red blood cells test system INVITOX No.37 Ispra. Italy ECVAM 1994.)
TABLE 2 ECVAM cosmetic product RBC Experimental irritation grading Standard
| L/D | Grading |
| ﹥100 | Has no irritation |
| 10﹤L/D≤100 | Micro-stimulation property |
| 1﹤L/D≤10 | Mild irritation |
| 0.1﹤L/D≤1 | Moderate irritation |
| L/D≤0.1 | Severe irritation |
Wherein L/D is the ratio of HC50 to DI, HC50 is the half-cell hemolytic concentration, and DI is the hemoglobin denaturation index.
TABLE 3 results of erythrocyte hemolysis test for each product
As can be seen from Table 3, the application examples 1-21 were non-irritating as determined by the ratio L/D of HC50 to DI. Therefore, the traditional Chinese medicine extract is safe and non-irritant when being applied to a washing and caring product, and does not cause scalp adverse reactions.
The present invention is illustrated in detail by the examples described above, but the present invention is not limited to the details described above, i.e., it is not intended that the present invention be implemented by relying on the details described above. It should be understood by those skilled in the art that any modification of the present invention, equivalent substitutions of the raw materials of the product of the present invention, addition of auxiliary components, selection of specific modes, etc., are within the scope and disclosure of the present invention.
Claims (24)
1. The traditional Chinese medicine extract is characterized in that the preparation raw materials of the traditional Chinese medicine extract comprise the following components in percentage by mass: 0.1 to 60 percent of white mulberry root-bark, 0.1 to 60 percent of ginger root, 0.1 to 60 percent of cacumen biotae, 0.1 to 60 percent of liquorice and 0.1 to 60 percent of Chinese magnoliavine fruit;
the traditional Chinese medicine extract is prepared by the method comprising the following steps:
(1) pretreatment: respectively crushing the cortex mori radicis, the ginger root, the cacumen biotae, the liquorice and the schisandra chinensis according to the formula ratio into powder, and mixing to obtain mixed powder;
(2) extraction: adding an extraction solvent into the mixed powder, soaking, separating and concentrating to obtain a concentrated solution, thus obtaining the traditional Chinese medicine extract;
the extraction solvent comprises water and/or ethanol.
2. The traditional Chinese medicine extract as claimed in claim 1, wherein the raw materials for preparing the traditional Chinese medicine extract comprise the following components in percentage by mass: 1-50% of white mulberry root-bark, 1-50% of ginger root, 1-50% of cacumen biotae, 1-50% of licorice and 1-50% of schisandra fruit.
3. The traditional Chinese medicine extract as claimed in claim 1 or 2, wherein the raw materials for preparing the traditional Chinese medicine extract comprise the following components in percentage by mass: 30% of cortex mori, 20% of ginger root, 20% of cacumen biotae, 10% of liquorice and 20% of schisandra chinensis.
4. The traditional Chinese medicine extract as claimed in claim 1 or 2, wherein the raw materials for preparing the traditional Chinese medicine extract comprise the following components in percentage by mass: 50% of cortex mori, 10% of ginger root, 10% of cacumen biotae, 10% of liquorice and 20% of schisandra chinensis.
5. The traditional Chinese medicine extract as claimed in claim 1 or 2, wherein the raw materials for preparing the traditional Chinese medicine extract comprise the following components in percentage by mass: 5% of cortex mori, 10% of ginger root, 40% of cacumen biotae, 15% of liquorice and 30% of schisandra chinensis.
6. The traditional Chinese medicine extract as claimed in claim 1 or 2, wherein the raw materials for preparing the traditional Chinese medicine extract comprise the following components in percentage by mass: 15% of cortex mori, 25% of ginger root, 25% of cacumen biotae, 25% of liquorice and 10% of schisandra chinensis.
7. The traditional Chinese medicine extract as claimed in claim 1 or 2, wherein the raw materials for preparing the traditional Chinese medicine extract comprise the following components in percentage by mass: 5% of cortex mori, 30% of ginger root, 20% of cacumen biotae, 30% of liquorice and 15% of schisandra chinensis.
8. A method for preparing the traditional Chinese medicine extract according to any one of claims 1 to 7, wherein the method comprises the following steps:
(1) pretreatment: respectively crushing the cortex mori radicis, the ginger root, the cacumen biotae, the liquorice and the schisandra chinensis according to the formula ratio into powder, and mixing to obtain mixed powder;
(2) extraction: adding an extraction solvent into the mixed powder, soaking, separating and concentrating to obtain a concentrated solution, thus obtaining the traditional Chinese medicine extract;
the extraction solvent comprises water and/or ethanol.
9. The method according to claim 8, wherein in step (1), the particle size of the powder is 100-500 mesh.
10. The production method according to claim 8, wherein in the step (2), the mass ratio of the extraction solvent to the mixed powder is 1:1 to 40: 1.
11. The method according to claim 8, wherein the soaking time in the step (2) is 1 to 5 hours.
12. The method according to claim 8, wherein the soaking in the step (2) is carried out in a water bath at a temperature of 40 to 90 ℃.
13. The method according to claim 8, wherein in the step (2), the separation method comprises centrifugal separation.
14. The production method according to claim 8, wherein step (3) is performed after step (2): and (3) purifying the concentrated solution obtained in the step (2), and then concentrating and filtering to obtain the traditional Chinese medicine extract.
15. The method according to claim 14, wherein in the step (3), the purification method comprises purification using a macroporous resin.
16. The method of claim 15, wherein the macroporous resin has a particle size of 20-50 mesh.
17. The method of claim 15, wherein the macroporous resin comprises any one or a combination of at least two of AB-8, D1300, and D101.
18. The method according to claim 14, wherein in the step (2) and the step (3), the concentration method comprises rotary evaporation.
19. The preparation method according to claim 8, wherein the preparation method specifically comprises the steps of:
(1) pretreatment: respectively crushing the cortex mori radicis, the ginger root, the cacumen biotae, the liquorice and the schisandra chinensis according to the formula ratio into 500-mesh powder with the granularity of 100 meshes, and mixing to obtain mixed powder;
(2) extraction: adding an extraction solvent into the mixed powder according to the mass ratio of the extraction solvent to the mixed powder of 1:1-40:1, soaking in a water bath kettle at 40-90 ℃ for 1-5 hours, and performing centrifugal separation and rotary evaporation to obtain a concentrated solution;
(3) and (3) purification: purifying the concentrated solution by using macroporous resin with the granularity of 20-50 meshes, and then performing rotary evaporation and filtration to obtain the traditional Chinese medicine extract.
20. A washing and care product, characterized in that the washing and care product contains the traditional Chinese medicine extract of any one of claims 1 to 7.
21. The washing and care product of claim 20, wherein the traditional Chinese medicine extract accounts for 0.1-80% of the washing and care product by mass.
22. The washing and care product of claim 21, wherein the traditional Chinese medicine extract accounts for 1-50% of the washing and care product by mass.
23. The washing and care product of claim 22, wherein the traditional Chinese medicine extract accounts for 5-40% of the washing and care product by mass.
24. The rinse-care product of claim 20, wherein the rinse-care product comprises a shampoo, a hair spray, a leave-in hair conditioner, a conditioner, or a hair mask.
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| CN111329981B (en) * | 2020-02-25 | 2022-04-12 | 澳宝化妆品（惠州）有限公司 | Antibacterial, anti-inflammatory and blood circulation-promoting microcapsule Chinese herbal medicine composition and preparation method thereof |
| CN114848554B (en) * | 2022-05-24 | 2024-01-23 | 品高生物科技(广州)有限公司 | Plant compound capable of preventing hair loss and growing hair and preparation method thereof |
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Address after: 510663 No.15, Kelin Road, Guangzhou Science City, Guangzhou high tech Industrial Development Zone, Guangdong Province Patentee after: Guangzhou Huanya cosmetics technology Co.,Ltd. Address before: 510663 No.15, Kelin Road, Guangzhou Science City, Guangzhou high tech Industrial Development Zone, Guangdong Province Patentee before: GUANGZHOU HUANYA COSMETICS TECHNOLOGY Co.,Ltd. |