CN110025886A - Animal Naoliqing capsule is in body electrical stimulation device - Google Patents

Abstract

The invention provides an animal brain stereotaxic in-body electrical stimulation device, comprising a nerve positioning shell and at least one stimulating electrode; the nerve positioning shell comprises a left shell and a right shell coaxially connected at the inner ends, the left shell and the right shell The outer ends of the sleeves are provided with nerve through holes for the nerves to be stimulated to pass through; the left and right shells are composed of hinged upper and lower half-shells, and the upper and lower half-shells of each shell are closed by a lock. The closing mechanism is locked; the stimulating electrode is installed on the left casing or the right casing, and the electrode contacts of the stimulating electrode can be radially adjusted in the corresponding casing. The invention provides an animal brain stereotaxic in-body electrical stimulation device, which can avoid the compression of the stimulation electrode contacts by internal organs, ensure relatively stable contact between the stimulation electrode contacts and the target nerve, and improve the research effect of electric stimulation experiments.

Description

Animal brain stereotaxic in vivo electrical stimulation device

technical field

The invention relates to the technology of animal experimental medical instruments, in particular to an animal brain stereotaxic in-body electrical stimulation device.

Background technique

The nervous system coordinates movements and transmits signals to different parts of the body. The receptors sense various stimuli from the internal and external environment, and after they are transmitted to the central nervous system through afferent nerves for integration, they then transmit information to various organs of the body through efferent nerves, regulate the activities of various organs, and ensure the coordination of the activities of various organs and systems in the body. To maintain normal life activities, it is of great significance to study the effect of nerve stimulation on the body.

Neurological dysfunction is a large category of neurological diseases with a high incidence, including severe Parkinson's disease and other movement disorders, epilepsy, intractable pain, etc. The result is that the patient is significantly disabled. Implantable neurostimulator is a kind of electronic device that helps the function recovery after nerve injury. The stimulation electrode contacts are in direct contact with the stimulation nerve target, and the target nerve is stimulated by applying a certain degree of current pulse to adjust or restore the brain. The function of nerves or muscles that restores biological functions to normal functioning.

At present, when electrical stimulation surgery is performed on animals using a brain stereotaxic apparatus, the time for electrical stimulation of brain nerves is usually performed by inserting an external electrode rod from the top of the animal's head. When electrical stimulation is performed on the animal's intra-abdominal nerve, the animal's body after positioning cannot be twisted, and twisting can easily damage the spine or even lead to death. Therefore, the external electrode is not easy to insert, and it is not easy to achieve stable stimulation of the intra-abdominal target. In addition, the abdominal incision is usually large, and it is necessary to keep the incision open during the external electrode stimulation process. The electrode contacts of the external electrode are easily compressed by internal organs and deviate from the target nerve, which affects the continuous stimulation monitoring effect.

SUMMARY OF THE INVENTION

The invention provides an animal brain stereotaxic in-body electrical stimulation device, which can avoid the compression of the stimulation electrode contacts by internal organs, ensure relatively stable contact between the stimulation electrode contacts and the target nerve, and improve the research effect of electric stimulation experiments.

In order to realize the above-mentioned technical purpose and achieve the above-mentioned technical effect, the present invention solves the above-mentioned problems through the following technical solutions:

The animal brain stereotaxic in-body electrical stimulation device includes a nerve positioning shell and at least one stimulating electrode; the nerve positioning shell includes a left shell and a right shell that are coaxially socketed at the inner ends, and the outer shells of the left and right shells are Both ends are provided with nerve through holes for the nerves to be stimulated to pass through; the left and right shells are composed of hinged upper and lower half shells, and the upper and lower half shells of each shell are locked by a locking mechanism at the closed place. There are sliding positioning grooves and sliders that interact with each other between the upper half shells and between the lower half shells of the left and right shells at the socket joint. The sliding positioning groove is a tooth comb-shaped groove structure. It includes a straight groove for the sliding block to slide axially, and a circumferential groove that is equally spaced on the side of the straight groove for the sliding block to slide in and locate. The closures of the upper and lower half shells of the cover are flush; the stimulating electrode is installed on the left cover or the right cover, and the electrode contacts of the stimulating electrode can be radially adjusted in the corresponding cover.

In the above solution, the positioning shell is composed of a left shell and a right shell that are coaxially connected, and there are sliding positioning grooves and sliders that interact with each other at the socket. The working length of the shell is adjustable. At the same time, the left and right shells are composed of hinged upper and lower half shells. The hinged surface cuts the nerve through holes at the outer ends of the left and right shells. When the upper and lower half shells are opened, it is convenient to insert the nerve to be tested. , closing the upper and lower half shells can better locate the positioning shell on the nerve to be measured. Adjusting the radial distance between the stimulating electrode and the corresponding sheath can ensure better contact between the electrode contact and the nerve to be measured.

The diameter of the outer end of each shell is smaller than the diameter of the inner end so that the outer section of each shell is in the shape of a frustum. The left and right shells adopt a truncated cone structure whose outer ends are gradually reduced, so that the outer side of the shell has a buffer slope, which can reduce the pressure of the inner cortex of the experimental body.

An elastic rubber pad is arranged on the hole wall of the nerve through hole, which can reduce the compression on the nerve and at the same time improve the applicable range of the nerve through hole.

The locking mechanism includes buckles and buckle grooves respectively provided on the upper and lower half shells.

The stimulating electrode includes an electrode rod, the electrode contact is arranged at the front end of the electrode rod, the rear end of the electrode rod is connected with an external power supply and a control device through a circuit, and the electrode rod is screwed to the corresponding shell through a screw body in the middle. into the electrode mounting screw holes opened on the top.

The advantages and effects of the present invention are:

1. In the above scheme of the present invention, the left and right shells constituting the nerve positioning shells can slide toward each other or in opposite directions, and the working length can be adjusted according to the nerve length of the experimental body.

2. In the present invention, the left and right shells are respectively formed by hinged upper and lower half shells, and opening the upper and lower half shells can facilitate the placement of the nerve to be detected into the device.

3. The stimulating electrode of the present invention is threadedly connected to the nerve positioning sheath, and the length of the threaded connection can be adjusted, which can realize the adjustment of the distance between the electrode contact and the central axis of the nerve positioning sheath, and make the device more suitable for different diameters of the nerve to be detected. stimulus experiment.

Description of drawings

1 is a schematic structural diagram of an animal brain stereotaxic in-body electrical stimulation device;

Fig. 2 is the structural schematic diagram when the upper and lower half shells in Fig. 1 are opened;

Fig. 3 is the structural representation when the right shell in Fig. 1 is opened;

FIG. 4 is a schematic diagram of the structure of the stimulation electrode.

Drawing number identification: 1. Stimulating electrode, 1-1, Electrode contact, 1-2, Electrode rod, 1-3, Screw body, 2, Left shell, 3, Right shell, 4, Neural through hole, 5 , Half shell, 6, Sliding positioning groove, 6-1, Straight groove, 6-2, Circumferential groove, 7, Slider, 8, Electrode mounting screw hole, 9, Buckle, 10, Nerve to be stimulated; 11 , Buckle slot.

Detailed ways

The present invention will be further described below with reference to the examples, but the present invention is not limited to these examples.

The animal brain stereotaxic in-body electrical stimulation device described in this embodiment includes a nerve positioning sheath and a stimulation electrode 1 . The nerve positioning sheath includes a left sheath 2 and a right sheath 3 , and a left sheath 2 and a right sheath. The inner end of the shell 3 is coaxially connected (the inner port of the right shell 3 is sleeved on the inner port of the left shell 2), and the outer ends of the left and right shells 2 and 3 are provided with coaxial nerves to be stimulated. 10 through the nerve through hole 4, the inner wall of the nerve through hole 4 is provided with an elastic rubber pad, and the outer end diameter of each shell is smaller than the inner end diameter so that the outer section of each shell is in the shape of a frustum, as shown in the figure. 1. As shown in Figure 2 and Figure 3.

The left and right shells 2 and 3 are composed of upper and lower half shells 5 hinged on the rear side. Each nerve passage hole 4 is divided into semicircular holes on the upper and lower half shells 5. , The lower half shell 5 is locked by the left locking mechanism at the closing position of the front side, and the upper and lower half shells 5 of the right shell 3 are locked by the right locking mechanism at the closing position of the front side. It includes a buckle 9 and a buckle groove 11 respectively arranged on the upper and lower half shells 5 , as shown in FIG. 1 , FIG. 2 , and FIG. 3 .

Interacting sliding positioning grooves 6 and The sliding block 7, each sliding positioning groove 6 is opened on the half shell 5 of the left casing 2, including a straight groove 6-1 along the axial direction and a circumferential direction opened on the side of the straight groove 6-1 at equal intervals and communicated with it In the groove 6-2, the two axial sliding blocks 7 are arranged on the half shell 5 of the right casing 2, and the distance between the two sliding blocks 7 is equal to the spacing between the adjacent circumferential grooves 6-2. The relative rotation between the casings 2 and 3, the two sliders 7 can be rotated in and out corresponding to the tail end and the front end of the adjacent circumferential groove 6-2, and the front end of the adjacent circumferential groove 6-2 is the straight groove In 6-1, the length of the nerve positioning shell can be adjusted axially between the left and right shells 2 and 3. After the length is adjusted in place, rotate the left and right shells 2 and 3 to make the two sliders 7 enter the length. The ends of the corresponding adjacent circumferential grooves 6-2 are axially limited. At this time, the closed ends of the upper and lower half shells 5 of the left and right shells 2 and 3 are flush with each other (left and right shells). The hinge ends of the upper and lower half shells 5 of 2 and 3 are flush with each other), and the upper and lower half shells 5 of the left and right shells 2 and 3 can be opened simultaneously by unfastening the buckle 9. The nerve 10 is placed in the working area, the upper and lower half shells 5 are closed and the buckle 9 is closed to position the device on the nerve 10 to be stimulated, as shown in FIG. 1 , FIG. 2 , and FIG. 3 .

The stimulating electrode 1 includes an electrode contact 1-1 and an electrode rod 1-2. The electrode rod 1-2 is screwed and installed on the lower half shell 5 of the left casing 2 through a screw body 1-3 in the middle. In the electrode installation screw hole 8 of the lower half shell 5, the electrode contact 1-1 is arranged on the front end of the electrode rod 1-2 in the lower half shell 5, and the rear end of the electrode rod 1-2 passes through the line outside the lower half shell 5 Connect the external power supply and control device, and adjust the radial position of the electrode contact 1-1 by screwing in and out of the screw body 1-3, so that the electrode contact 1-1 is in reliable contact with the nerve 10 to be stimulated, which can be applied to The test of the nerve 10 to be stimulated with different diameters is also convenient to adjust the contact area between the electrode contact 1-1 and the nerve to be stimulated 10 and the force exerted by the nerve to be stimulated 10, as shown in Figure 1, Figure 2, Figure 3, Figure 4 Show.

The working principle of this embodiment is:

1. Rotate the right casing 3 to turn the sliding block 7 at the connecting end from the circumferential groove 6-2 into the straight groove 6-1. The sliding block 7 slides along the straight groove 6-1 to adjust the left and right casings 2. The relative distance between 2 and 3. After the length adjustment is completed, reversely rotate the right casing 3 to turn the slider 7 from the straight groove 6-1 into the corresponding circumferential groove 6-2 and position the tail ends. At this time, the left and right casings 2 , The axial sliding of 3 is limited.

2. Unbuckle the left and right buckles 9 and open the upper half shell 5 of the left and right shells 2 and 3 at the same time, place the nerve to be stimulated 10 into the nerve positioning shell, and connect the nerve to be stimulated 10 with the left , The nerve through holes 4 (semi-circular holes) of the lower half shell 5 of the right shells 2 and 3 are matched with each other.

3. Rotate the electrode rod 1-2 to adjust the distance between the electrode contact 1-1 and the nerve 10 to be stimulated to ensure good contact between the two.

4. Turn down the upper half shell 5 of the left and right shells 2 and 3 at the same time to make it close with the lower half shell 5 and lock the left and right buckles 9, so that the nerve to be stimulated 10 is well positioned by the nerve shell. Wrapping can achieve a better positioning effect, and can ensure that the electrode contact 1-1 does not detach from the nerve 10 to be stimulated during the stimulation process.

The embodiments of the present invention are described above in detail with reference to the accompanying drawings, but the present invention is not limited to the described embodiments. Various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principle and spirit of the present invention and still fall within the protection scope of the present invention.

Claims (5)

1. Animal brain stereotaxic in-body electrical stimulation device, is characterized in that: comprise nerve positioning shell and at least one stimulating electrode (1); Described nerve positioning shell comprises the left shell (2) of inner end coaxial socket connection and the right shell (3), the outer ends of the left and right shells (2, 3) are provided with nerve through holes (4) for the nerve to be stimulated (10) to pass through; the left and right shells (2, 3) ) are composed of hinged upper and lower half-shells (5), the upper and lower half-shells (5) of each shell are locked by a locking mechanism at the closing place, and the left and right shells (2, 3) Interacting sliding positioning grooves (6) and sliders (7) are provided between the upper half shells (5) and between the lower half shells (5), and the sliding positioning grooves (6) are: The tooth-comb-shaped groove body structure includes straight grooves (6-1) for the sliding block (7) to slide axially, and the sides of the straight grooves (6-1) are equally spaced for the sliding block (7) to slide in and position. When the slider (7) slides into the circumferential groove (6-2) for positioning, the upper and lower half shells ( 5) is flush with the closure; the stimulation electrode (1) is mounted on the left casing (2) or the right casing (3), and the electrode contacts (1-1) of the stimulation electrode (1) can be adjusted radially in the corresponding shell. 2 . The animal brain stereotaxic in-body electrical stimulation device according to claim 1 , wherein the diameter of the outer end of each shell is smaller than the diameter of the inner end, so that the outer section of each shell is in the shape of a frustum. 3 . 3 . The animal brain stereotaxic in-body electrical stimulation device according to claim 1 , wherein an elastic rubber pad is provided on the hole wall of the nerve through hole ( 4 ). 4 . 4. The animal brain stereotaxic in-body electrical stimulation device according to any one of claims 1 to 3, characterized in that the locking mechanism comprises buckles respectively provided on the upper and lower half-shells (5). (9) and buckle slot (11). 5. The animal brain stereotaxic in-body electrical stimulation device according to any one of claims 1 to 3, wherein the stimulation electrode (1) comprises an electrode rod (1-2), and the electrode contact (1-1) is arranged at the front end of the electrode rod (1-2), the rear end of the electrode rod (1-2) is connected to an external power supply and a control device through a line, and the electrode rod (1-2) passes through the screw in the middle The bodies (1-3) are screwed into the electrode mounting screw holes (8) provided on the corresponding casing.