CN110007101B - Detection apparatus and detection method - Google Patents
Detection apparatus and detection method Download PDFInfo
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- CN110007101B CN110007101B CN201910279544.9A CN201910279544A CN110007101B CN 110007101 B CN110007101 B CN 110007101B CN 201910279544 A CN201910279544 A CN 201910279544A CN 110007101 B CN110007101 B CN 110007101B
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- 238000001514 detection method Methods 0.000 title claims abstract description 94
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 199
- 238000000034 method Methods 0.000 claims description 13
- 239000003550 marker Substances 0.000 claims description 6
- 238000003556 assay Methods 0.000 claims 2
- 238000010586 diagram Methods 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 230000013011 mating Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00722—Communications; Identification
- G01N35/00732—Identification of carriers, materials or components in automatic analysers
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- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
A detection apparatus and a detection method. The detection apparatus includes: a reaction detection mechanism for accommodating a plurality of reagent containers and a plurality of sample containers; a reagent compartment for housing a plurality of reagent cartridges; the reagent cartridge is for housing a plurality of the reagent containers; the reagent container in the reagent cartridge is used for replenishing or replacing into the reaction detection mechanism; the sample container has a first marking thereon; the reagent tube is provided with a second mark; first identifying means for identifying the first indicia on the sample container; and second identifying means for identifying the second indicia on the reagent cartridge. The detection device is higher in automation degree, and the reagent container with the reagent solution can be replaced intelligently, efficiently and accurately.
Description
Technical Field
The invention relates to the field of medical equipment, in particular to detection equipment and a detection method.
Background
Currently, detection devices based on medical use are generally detected by various principles. Corresponding detection equipment is inconvenient in use, and the requirement of people on the automation degree of detection is higher and higher.
The existing detection equipment is low in automation degree, easy to operate by mistake, large in size, high in cost and not matched with the modern hospital laboratory environment.
For more detection devices for existing medical applications reference is made to chinese patent publication No. CN 202720238U.
Disclosure of Invention
The invention solves the problem to provide a detection device comprising: a reaction detection mechanism for accommodating a plurality of reagent containers and a plurality of sample containers; a reagent compartment for housing a plurality of reagent cartridges; the reagent cartridge is for housing a plurality of the reagent containers; the reagent container in the reagent cartridge is used for replenishing or replacing into the reaction detection mechanism; the sample container has a first marking thereon; the reagent tube is provided with a second mark; first identifying means for identifying the first indicia on the sample container; and second identifying means for identifying the second indicia on the reagent cartridge.
Optionally, the reaction detection mechanism includes a reaction detection zone and a sample zone; the reaction detection zone is used for accommodating the reagent container; the sample area is used for accommodating the sample container; and the detection device further comprises a sample adding device.
Optionally, the reaction detection area is a first annular groove area, the sample area is a second annular groove area, and the second annular groove area surrounds the first annular groove area.
Optionally, the first annular groove area is a rotation area; the second annular groove area is a rotation area.
Optionally, the first annular groove area surrounds an annular platform area, and the sample adding device is located in the annular platform area; the detection equipment further comprises a lifting device, and the lifting device is used for driving the reagent cabin to lift and move above the reaction detection mechanism.
Optionally, the sample adding device is located beside the reaction detection mechanism; the detection equipment further comprises a rotating device, and the rotating device is used for driving the reagent cabin to horizontally move.
Optionally, the reagent container is cylindrical, the diameter of the opening of the reagent container is smaller than the diameter of the container main body, and the top of the side wall of the reagent container is provided with a chamfer; the reagent cartridge has side openings from top to bottom.
Optionally, the bottom of the side wall of the reagent tube is provided with an anti-sliding structure; the bottom of the reagent cabin is provided with a drop control structure.
In order to solve the above problems, the present invention further provides a detection method, including: placing at least one reagent container and at least one sample container in a reaction detection mechanism; placing at least one reagent cartridge in a reagent compartment, the reagent cartridge having at least one of the reagent containers therein, the reagent container located within the reagent cartridge for replenishment or replacement into a reaction detection mechanism; providing a first mark on the sample container; providing a second marker on the reagent cartridge; identifying the first mark on the sample container with a first identification device; identifying the second mark on the reagent cartridge with a second identification device; and matching the first mark and the second mark after identification.
Optionally, the first mark is a two-dimensional code or a bar code; the second mark is a two-dimensional code or a bar code; the first mark is arranged on the outer side surface of the sample container; the second mark is arranged on the outer side face of the reagent tube barrel.
In one aspect of the technical solution of the present invention, the first mark is disposed on the sample container, the second mark is disposed on the reagent tube, and the first recognition device and the second recognition device are matched, so that the detection device can automatically recognize that the sample container corresponds to the correct reagent tube, the process of updating and replacing the reagent container (with the reagent solution) becomes automatic, the accuracy is higher, and the whole process is intelligent and efficient.
After the first and second identification means have identified the first and second markers, respectively, the overall detection device will be clear that it is necessary to update a reagent cartridge in the reagent compartment, in which specific location of the reaction detection mechanism a certain reagent container of the reagent cartridge is to be updated.
Drawings
FIG. 1 is a schematic diagram of a detection apparatus in an embodiment;
FIG. 2 is a schematic illustration of a reagent container, sample container and reagent cartridge;
FIGS. 3 to 7 are schematic views showing a process of separating a reagent vessel from a reagent cartridge (reagent chamber);
fig. 8 is a schematic diagram of a detection apparatus in another embodiment.
Detailed Description
The present invention will be described in detail with reference to the accompanying drawings for more clear illustration.
An embodiment of the present invention provides a detection apparatus, as shown in fig. 1, including the following structure.
A reaction detection mechanism 11, the reaction detection mechanism 11 being configured to accommodate a plurality of reagent containers 111 and a plurality of sample containers 112.
A reagent compartment 12, said reagent compartment 12 being adapted to accommodate a plurality of reagent cartridges 121. The reagent cartridge 121 is adapted to receive a plurality of the reagent containers 111. The reagent container 111 in the reagent cartridge 121 is used for replenishment or replacement into the reaction detection mechanism 11.
The sample container 112 has a first indicia 131 thereon.
The reagent cartridge 121 has a second marking 132 thereon.
A first identification means 141, said first identification means 141 being adapted to identify said first marking 131 on said sample container 112.
A second identification means 142, said second identification means 142 being adapted to identify said second indicia 132 on said reagent cartridge 121.
Referring further to fig. 1, the reaction detecting mechanism 11 includes a reaction detecting area (not labeled) and a sample area (not labeled). The reaction detection zone is for accommodating the reagent vessel 111. The sample area is for receiving the sample container 112. And the detection apparatus further comprises a loading device 16.
As shown in fig. 1, the reaction detection area is a first annular groove area, the sample area is a second annular groove area, and the second annular groove area surrounds the first annular groove area. In other embodiments, the reaction detection zone and the sample zone may be other shaped well zones.
In this embodiment, the first annular groove area is a rotation area. The second annular groove area is a rotation area. Such rotating zones may be realized by arranging their bottoms to be rotatable, while the separation structure between the two zones (shown as a circular wall structure) may be a stationary structure or a rotatable structure.
As shown in fig. 1, the first annular groove area surrounds an annular land (not labeled), and the sample loading device 16 is located in the annular land, specifically on the upper surface of the annular land.
As shown in fig. 1, the detection apparatus further comprises a lifting device 15, and the lifting device 15 is used for driving the reagent compartment 12 to move up and down above the reaction detection mechanism 11. Typically, the reagent vessel 12 can be raised at least up to a level higher than the loading device 16, thereby ensuring that the corresponding other operations of the reaction detection means 11 are performed.
In this embodiment, as shown in fig. 1, the loading device 16 has at least two nodes (not labeled) that can be bent so that the loading device 16 can load the corresponding container.
As shown in fig. 2, in this embodiment, the reagent container 111 has a cylindrical shape, and the diameter of the opening of the reagent container 111 is smaller than the diameter of the container body, and the top of the sidewall of the reagent container 111 has a chamfer. Such a configuration facilitates subsequent stacking of a plurality of the reagent containers 111 together, and facilitates their replacement into the corresponding configuration one by one. Fig. 2 also shows that the first indicia 131 is located on the outer side wall of the reagent vessel 111.
As shown in fig. 2, the reagent cartridge 121 has side openings (not labeled) from top to bottom. The side openings serve to prevent the reagent vessel 111 from falling directly from the upper part to the bottom of the reagent cartridge 121. That is, the side opening is used to slowly place the reagent container 111 at the bottom of the reagent cartridge 121. I.e. the presence of the side openings, allows other structures to be controlled directly to the reagent vessel 111, so that the reagent vessel 111 can be lowered at a desired speed under control.
In this embodiment, the first mark 131 is a two-dimensional code or a bar code, or may be other suitable identification codes.
In this embodiment, the second mark 132 is a two-dimensional code or a bar code, or may be other suitable identification codes.
As shown in fig. 2 to 7, the bottom of the side wall of the reagent tube 121 is provided with an anti-slip structure 1211. The bottom of the reagent chamber 12 is provided with a drop control structure (not shown).
Fig. 2 shows the outer surface structure of the anti-slip structure 1211, and fig. 3 to 7 show the cross-sectional structure of the anti-slip structure 1211. To provide the anti-slip feature 1211, a small opening (not shown) is required in the bottom of the side wall of the reagent cartridge 121.
Fig. 3 shows that the drop control structure includes a fixed upper spike structure 122 and a movable transverse spike structure 123. The movable cross-hair structure 123 is capable of moving laterally in a horizontal direction. Note that the drop control structure is of the structure of the reagent chamber 12, and not of the reagent cartridge 121.
The process of mating the slide-down prevention structure 1211 and the drop control structure is described with reference to fig. 3 to 7.
When the bottommost reagent container 111 reaches the anti-slip feature 1211, as in fig. 3, it is held against the anti-slip feature 1211 so as not to slide directly out of the reagent cartridge 121. I.e. to ensure the safety of the reagent vessel 111 in the reagent cartridge 121. At this point, the reagent cartridge 121 has not been fully placed into the reagent compartment 12, i.e., the fixed spike structure 122 has not yet begun to act on the anti-slip structure 1211.
As shown in fig. 4, after the reagent cartridge 121 is completely placed in the reagent chamber 12, the fixed upper spike structure 122 abuts against the anti-slip structure 1211, so that the anti-slip structure 1211 is turned outwards, and the stack of reagent containers 111 continues to drop a distance until it is caught by the movable transverse spike structure 123, thereby achieving a new stable state. To better push the slip-off preventing structure 1211, the upper end of the fixed spike 122 may be designed as an inclined surface.
When it is desired to control the descent of a reagent vessel 111 from the reagent cartridge 121, as shown in fig. 5, the movable transverse piercing structure 123 is controlled to move laterally instantaneously (corresponding to the movement of the two parts respectively to the left and right in fig. 4 and 5), so that the lowermost reagent vessel 111 slides smoothly out. The movable transverse piercing structure 123 need only move laterally momentarily, so that a portion of the lowermost reagent container 111 slides out. During the continued sliding of the reagent vessel 111, the movable cross-hair structure 123 may be controlled to resume the state shown in fig. 4, i.e. at this time, the movable cross-hair structure 123 has a force converging towards the middle, which force causes a friction force between the tip of the movable cross-hair structure 123 and the reagent vessel 111, so that the sliding process of the reagent vessel 111 is slower and balanced.
In fig. 6, the force of the movable cross-pin 123 toward the middle may also be used to start the movement of the movable cross-pin 123 toward the middle when the lowermost reagent container 111 slides down to the vicinity of its opening (the reason is that the diameter of the opening of the reagent container 111 is smaller than the diameter of the container body, as described above, as shown in fig. 2), so as to timely catch the reagent container 111 at the sub-bottom and prevent the reagent container 111 at the sub-bottom from sliding down.
When the lowermost reagent vessel 111 is completely separated from the underside of the reagent chamber 12 as in fig. 7, the original sub-bottom reagent vessel 111 is changed back to the lowermost reagent vessel 111 in the reagent cartridge 121, and it can be seen that the operation of controlling the removal of one reagent vessel 111 from the reagent chamber 12 (and for placement in a desired location) is achieved from fig. 3 to 7.
In other embodiments, other structures may be used to update the reagent containers 111 one by one.
Detection devices typically require that reagent solutions in reagent containers in a reaction detection mechanism be added to a sample container during the detection process. Accordingly, when a reagent solution is either insufficient or depleted, it is necessary to take it from the reagent compartment for replenishment. In the conventional detection apparatus, when a reagent container containing a reagent solution is obtained from a reagent chamber, the reagent container is often prone to error, and the reagent container is updated to an error position, so that the error reagent solution is added to a sample later.
In the detection device provided in this embodiment, the first mark 131 is disposed on the sample container 112, the second mark 132 is disposed on the reagent tube 121, and the first identification device 141 and the second identification device 142 are matched, so that the detection device can automatically identify that the sample container corresponds to the correct reagent tube, the process of updating and replacing the reagent container 111 becomes automatic, the accuracy is higher, and the whole process is intelligent and efficient.
After the first and second identification means 141, 142 have identified the first and second markings 131, 132, respectively, the overall detection device will be aware that it is necessary to update a certain reagent container 111 of the reagent cartridge 121 in the reagent compartment 12 into a specific position of the reaction detection mechanism 11.
The embodiment of the invention also provides a detection method, which is applied to the detection equipment of the previous embodiment for the sake of materialization, and specifically comprises the following steps:
placing at least one reagent container 111 and at least one sample container 112 in the reaction detection mechanism 11;
placing at least one reagent cartridge 121 in a reagent compartment 12, said reagent cartridge 121 having at least one said reagent container 111 therein, said reagent container 111 located within said reagent cartridge 121 for replenishment or replacement into a reaction detection mechanism 11;
providing a first marker 131 on the sample container 112;
a second marker 132 is provided on the reagent cartridge 121;
identifying the first indicia 131 on the sample container 112 using a first identification device 141;
identifying the second indicia 132 on the reagent cartridge 121 using a second identification device 142;
The first mark 131 and the second mark 132 after recognition are matched.
Wherein, the first mark 131 is a two-dimensional code or a bar code. The second mark 132 is a two-dimensional code or a bar code. The first mark 131 is disposed on the outer side surface of the sample container 112. The second mark 132 is disposed on the outer side of the reagent tube 121.
It should be noted that the method may be performed in other corresponding detection apparatuses, as well as the detection apparatus specifically applied to the foregoing embodiment.
Another embodiment of the present invention provides a detection apparatus, as shown in fig. 8, including the following structure.
A reaction detecting mechanism 21, the reaction detecting mechanism 21 being configured to accommodate a plurality of reagent containers 211 and a plurality of sample containers 212.
A reagent compartment 22, said reagent compartment 22 being adapted to accommodate a plurality of reagent cartridges 221. The reagent cartridge 221 is adapted to receive a plurality of the reagent containers 211 (the reagent containers 211 within the reagent cartridge 221 are not shown). The reagent container 211 in the reagent cartridge 221 is used for replenishment or replacement into the reaction detection mechanism 21.
The sample container 212 has a first marking 231 thereon. The reagent cartridge 221 has a second marking 232 thereon.
A first identification means 241, said first identification means 241 being adapted to identify said first marking 231 on said sample container 212.
A second identification means 242, said second identification means 242 being adapted to identify said second marking 232 on said reagent cartridge 221.
Referring further to fig. 8, the reaction detecting mechanism 21 includes a reaction detecting region (not labeled) and a sample region (not labeled). The reaction detection zone is for accommodating the reagent vessel 211. The sample area is for receiving the sample container 212. And the detection device further comprises a sample adding device 26.
As shown in fig. 8, the reaction detection area is a first annular groove area, the sample area is a second annular groove area, and the second annular groove area surrounds the first annular groove area. In other embodiments, the reaction detection zone and the sample zone may be other shaped well zones.
In this embodiment, the first annular groove area is a rotation area. The second annular groove area is a rotation area. Such rotating zones may be realized by arranging their bottoms to be rotatable, while the separation structure between the two zones (shown as a circular wall structure) may be a stationary structure or a rotatable structure. As shown in fig. 8, the first annular groove region surrounds an annular land region (not labeled).
In contrast to the previous embodiment, the loading device 26 is located beside the reaction detection mechanism 21 as shown in FIG. 8. The detection device further comprises a rotating device 25, wherein the rotating device 25 is used for driving the reagent compartment 22 to horizontally move. The first motion fixing position of the horizontal motion is located above the reaction detecting mechanism 21, and the second motion fixing position of the horizontal motion is located above the side of the reaction detecting mechanism 21.
In this embodiment, the second identification means 242 may be located just beside the reagent compartment 22 when the reagent compartment 22 reaches the second, fixed, movement position. In another embodiment, it may be that the second identification means 242 is movable.
The detection device provided in this embodiment can also be used to update the replacement reagent container 211 efficiently, accurately and automatically, and further, because of the horizontal movement, energy is saved. And meanwhile, the reaction detection mechanism 21 can be more convenient for other operations of staff by a horizontal movement mode.
In another embodiment of the present invention, another detection method is provided, and for implementation, the method is applied to the detection apparatus of the foregoing embodiment, and specifically includes:
placing at least one reagent container 211 and at least one sample container 212 in a reaction detection mechanism 21;
Placing at least one reagent cartridge 221 in a reagent compartment 22, said reagent cartridge 221 having at least one said reagent container 211 therein, said reagent container 211 located within said reagent cartridge 221 for replenishment or replacement into a reaction detection mechanism 21;
providing a first marker 231 on the sample container 212;
a second marker 232 is provided on the reagent cartridge 221;
identifying the first marking 231 on the sample container 212 using a first identification device 241;
identifying the second marking 232 on the reagent cartridge 221 using a second identification device 242;
The first mark 231 and the second mark 232 after recognition are matched.
Wherein, the first mark 231 is a two-dimensional code or a bar code. The second mark 232 is a two-dimensional code or a bar code. The first mark 231 is disposed on the outer side of the sample container 212. The second mark 232 is disposed on the outer side of the reagent tube 221.
It should be noted that the method may be performed in other corresponding detection apparatuses, as well as the detection apparatus specifically applied to the foregoing embodiment.
Although the present invention is disclosed above, the present invention is not limited thereto. Various changes and modifications may be made by one skilled in the art without departing from the spirit and scope of the invention, and the scope of the invention should be assessed accordingly to that of the appended claims.
Claims (8)
1. A detection apparatus, characterized by comprising:
a reaction detection mechanism for accommodating a plurality of reagent containers and a plurality of sample containers;
A reagent compartment for housing a plurality of reagent cartridges; the reagent cartridge is for housing a plurality of the reagent containers; the reagent container in the reagent cartridge is used for replenishing or replacing into the reaction detection mechanism;
the sample container has a first marking thereon;
the reagent tube is provided with a second mark;
First identifying means for identifying the first indicia on the sample container;
a second identification means for identifying the second indicia on the reagent cartridge;
the reagent container is cylindrical, the diameter of an opening of the reagent container is smaller than the diameter of the container main body, and the top of the side wall of the reagent container is provided with a chamfer; the reagent cartridge has side openings from top to bottom;
the bottom of the side wall of the reagent tube is provided with an anti-sliding structure; the bottom of the reagent cabin is provided with a drop control structure; the drop control structure comprises a fixed upper thorn structure and a movable transverse thorn structure; after the reagent tube is completely put into the reagent cabin, the fixed upper thorn structure props against the anti-sliding structure, so that the anti-sliding structure is outwards turned.
2. The test device of claim 1, wherein the reaction detection mechanism comprises a reaction detection zone and a sample zone; the reaction detection zone is used for accommodating the reagent container; the sample area is used for accommodating the sample container; and the detection device further comprises a sample adding device.
3. The assay device of claim 2 wherein the reaction detection zone is a first annular groove zone and the sample zone is a second annular groove zone, the second annular groove zone surrounding the first annular groove zone.
4. A test device as claimed in claim 3, wherein the first annular groove region is a region of rotation; the second annular groove area is a rotation area.
5. The test apparatus of claim 4, wherein said first annular groove zone surrounds an annular land, said sample application device being located in said annular land;
The detection equipment further comprises a lifting device, and the lifting device is used for driving the reagent cabin to lift and move above the reaction detection mechanism.
6. The assay device of claim 4, wherein said loading means is located beside said reaction detection mechanism;
The detection equipment further comprises a rotating device, and the rotating device is used for driving the reagent cabin to horizontally move.
7. A method of detection comprising:
Placing at least one reagent container and at least one sample container in a reaction detection mechanism;
Placing at least one reagent cartridge in a reagent compartment, the reagent cartridge having at least one of the reagent containers therein, the reagent container located within the reagent cartridge for replenishment or replacement into a reaction detection mechanism;
providing a first mark on the sample container;
providing a second marker on the reagent cartridge;
Identifying the first mark on the sample container with a first identification device;
Identifying the second mark on the reagent cartridge with a second identification device;
Matching the first mark and the second mark after identification;
the reagent container is cylindrical, the diameter of an opening of the reagent container is smaller than the diameter of the container main body, and the top of the side wall of the reagent container is provided with a chamfer; the reagent cartridge has side openings from top to bottom;
the bottom of the side wall of the reagent tube is provided with an anti-sliding structure; the bottom of the reagent cabin is provided with a drop control structure; the drop control structure comprises a fixed upper thorn structure and a movable transverse thorn structure.
8. The method of detection of claim 7, wherein the first mark is a two-dimensional code or a bar code; the second mark is a two-dimensional code or a bar code; the first mark is arranged on the outer side surface of the sample container; the second mark is arranged on the outer side face of the reagent tube barrel.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910279544.9A CN110007101B (en) | 2019-04-09 | 2019-04-09 | Detection apparatus and detection method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910279544.9A CN110007101B (en) | 2019-04-09 | 2019-04-09 | Detection apparatus and detection method |
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| CN110007101A CN110007101A (en) | 2019-07-12 |
| CN110007101B true CN110007101B (en) | 2024-06-11 |
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| CN116413460A (en) * | 2021-12-31 | 2023-07-11 | 力合科技（湖南）股份有限公司 | Automatic solution analysis device |
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| CN209927871U (en) * | 2019-04-09 | 2020-01-10 | 安邦（厦门）生物科技有限公司 | Detection device |
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| US7360984B1 (en) * | 2000-03-15 | 2008-04-22 | Roche Diagnostics Corp. | Automatic analyzer and part feeding device used for the analyzer |
| CN1788201A (en) * | 2003-03-31 | 2006-06-14 | 视觉生物体系有限公司 | A method and apparatus for fluid dispensation, preparation and dilution |
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