CN109985307B - Artificial cochlea electrode keel and electrode array manufacturing method - Google Patents
Artificial cochlea electrode keel and electrode array manufacturing method Download PDFInfo
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- CN109985307B CN109985307B CN201711478516.7A CN201711478516A CN109985307B CN 109985307 B CN109985307 B CN 109985307B CN 201711478516 A CN201711478516 A CN 201711478516A CN 109985307 B CN109985307 B CN 109985307B
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- 238000004519 manufacturing process Methods 0.000 title claims abstract description 13
- 210000003477 cochlea Anatomy 0.000 title claims abstract description 12
- 238000000034 method Methods 0.000 claims abstract description 42
- 239000007943 implant Substances 0.000 claims abstract description 31
- 238000003466 welding Methods 0.000 claims abstract description 24
- 238000003825 pressing Methods 0.000 claims abstract description 20
- 238000005520 cutting process Methods 0.000 claims abstract description 8
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 7
- 239000000741 silica gel Substances 0.000 claims abstract description 6
- 229910002027 silica gel Inorganic materials 0.000 claims abstract description 6
- 238000003698 laser cutting Methods 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 5
- 238000005553 drilling Methods 0.000 claims description 4
- 238000004806 packaging method and process Methods 0.000 claims description 4
- 238000005516 engineering process Methods 0.000 abstract description 6
- 230000000694 effects Effects 0.000 abstract description 5
- 239000011248 coating agent Substances 0.000 abstract description 3
- 238000000576 coating method Methods 0.000 abstract description 3
- 238000004080 punching Methods 0.000 abstract description 2
- 238000005452 bending Methods 0.000 description 4
- 239000012634 fragment Substances 0.000 description 4
- 238000000338 in vitro Methods 0.000 description 3
- 238000001727 in vivo Methods 0.000 description 3
- 238000007493 shaping process Methods 0.000 description 3
- 230000001629 suppression Effects 0.000 description 3
- 238000010586 diagram Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- 208000003098 Ganglion Cysts Diseases 0.000 description 1
- 229910000566 Platinum-iridium alloy Inorganic materials 0.000 description 1
- 208000005400 Synovial Cyst Diseases 0.000 description 1
- 238000003491 array Methods 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 210000000860 cochlear nerve Anatomy 0.000 description 1
- 239000008119 colloidal silica Substances 0.000 description 1
- 230000005674 electromagnetic induction Effects 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 238000003754 machining Methods 0.000 description 1
- 235000001968 nicotinic acid Nutrition 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- HWLDNSXPUQTBOD-UHFFFAOYSA-N platinum-iridium alloy Chemical class [Ir].[Pt] HWLDNSXPUQTBOD-UHFFFAOYSA-N 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000008054 signal transmission Effects 0.000 description 1
- 229910000679 solder Inorganic materials 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0526—Head electrodes
- A61N1/0541—Cochlear electrodes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B21—MECHANICAL METAL-WORKING WITHOUT ESSENTIALLY REMOVING MATERIAL; PUNCHING METAL
- B21D—WORKING OR PROCESSING OF SHEET METAL OR METAL TUBES, RODS OR PROFILES WITHOUT ESSENTIALLY REMOVING MATERIAL; PUNCHING METAL
- B21D22/00—Shaping without cutting, by stamping, spinning, or deep-drawing
- B21D22/02—Stamping using rigid devices or tools
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
- B23P—METAL-WORKING NOT OTHERWISE PROVIDED FOR; COMBINED OPERATIONS; UNIVERSAL MACHINE TOOLS
- B23P15/00—Making specific metal objects by operations not covered by a single other subclass or a group in this subclass
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Otolaryngology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Electrotherapy Devices (AREA)
Abstract
The invention relates to a method for preparing an artificial cochlea electrode keel and an electrode array, which comprises the steps of punching or cutting an electrode grid, processing micropores on an electrode contact, welding an electrode wire and the electrode contact, pressing by a pressing jig, coating a proper amount of silica gel to form the electrode keel and the like. The method provided by the invention can prepare the general cochlear implant electrode keel, is suitable for cochlear implant electrodes of different shapes, improves the consistency of products, improves the production efficiency of cochlear implants, and reduces the production cost of enterprises. Particularly, the effect is more prominent after the advantages of a precision processing technology and a laser processing technology are fully utilized.
Description
Technical Field
The invention relates to the technical field of biomedical engineering bionics, in particular to a method for preparing an artificial cochlea electrode keel and an electrode array.
Background
The artificial cochlea consists of an implanted electrode in the cochlea, a speech processor, a microphone and a transmission device, wherein sound is received by the microphone and then converted into an electric signal, the electric signal is transmitted to the speech processor to be amplified and filtered, the signal is transmitted to a receiver by the transmitter, and the generated electric pulse is transmitted to a corresponding contact point, so that ganglion cells in the cochlea are stimulated, auditory nerves are excited, sound information is transmitted to the brain, and the auditory sense is generated.
The artificial cochlea comprises an in-vitro device and an in-vivo implanted device, wherein the signal transmission between the in-vitro device and the in-vivo implanted device is completed through electromagnetic induction, the in-vitro device and the in-vivo implanted device are separated by skin and are not connected through a lead. In the whole artificial cochlea system, the intracorporeal implanted device is the most critical part, the extracorporeal device can realize the recovery of auditory sense only through the intracorporeal implanted device, and the cochlear electrode array is the most important part of the intracorporeal implanted device. In the present cochlea electrode array antithetical couplet course of working, a large amount of work need rely on artifical manual operation to accomplish, and the uniformity is relatively poor, and especially the interval location of electrode contact mostly relies on the manual work to operate under the microscope, and the product uniformity is difficult to obtain guaranteeing.
Disclosure of Invention
In view of the above-mentioned shortcomings of the prior art, the present invention at least aims to provide a cochlear implant electrode keel and a method for manufacturing the electrode array so as to improve the consistency of the product.
To achieve the above and other related objects, an embodiment of the present invention provides a cochlear implant electrode keel preparation method, including the steps of: processing an electrode grid, namely manufacturing the electrode grid by a stamping process or a cutting process, wherein the electrode grid comprises electrode contacts which are arranged at a certain interval, and two ends of each electrode contact are respectively connected with two beams through cantilevers; a micropore processing step, wherein micropores are processed at one end of the electrode contact; a wire electrode welding step, wherein the connecting end of the wire electrode passes through the micropore, the free end of the wire electrode is positioned on one side of the electrode contact, one end of the electrode contact with the micropore is disconnected with the cantilever, one end of the electrode contact with the micropore is folded towards the other end of the electrode contact, and the connecting end of the wire electrode and the electrode contact are welded together; a step of bunching electrode wires, which is to repeat the step of welding the electrode wires, and to collect all the electrode wires together to form an electrode wire bundle after welding all the electrode contacts with the electrode wires; the electrode fossil fragments shaping step, place the electrode bars on the suppression tool, the suppression tool includes module one and module two, be formed with a plurality of notches after module one and module two merge between the two, the interval phase-match of the electrode contact on notch interval and the electrode bars, each electrode contact of placing on the suppression tool corresponds with the notch respectively, it makes the flute profile to impress the electrode contact notch, break off all cantilevers and electrode contact, form the electrode fossil fragments, scribble right amount silica gel and solidification in the electrode fossil fragments, then part module one and module two, take out the electrode fossil fragments.
In one embodiment, each electrode contact on the electrode grid comprises a long cantilever and a short cantilever, and the long cantilevers and the short cantilevers of two adjacent electrode contacts are alternately arranged, and the micro-hole is formed at one end of the electrode contact close to the short cantilever.
In one embodiment, the stamping process is a precision stamping process.
In one embodiment, the micro-holes are machined using a laser drilling process.
In one embodiment, the cutting process is a laser cutting process.
In one embodiment, the connection end of the wire electrode is inserted from above the micro hole, and after the connection end of the wire electrode and the electrode contact are welded together, the wire electrode is bent 180 degrees from one side of the electrode contact to the other side thereof from above the electrode contact.
In one embodiment, the wire electrode welding step further comprises welding together overlapping positions of the folded ends of the electrode contacts.
In one embodiment, the welding is by a laser welding process.
In one embodiment, the cantilever is disconnected from the electrode contact using a laser cutting process.
In one embodiment, the invention further provides a method for preparing the cochlear implant electrode array, which comprises the step of placing the electrode keel prepared according to any one of the methods for preparing the cochlear implant electrode keel in an electrode packaging mold to prepare the cochlear implant electrode array.
By the method, the general cochlear implant electrode keel can be prepared, is suitable for cochlear implant electrodes of different shapes, improves the consistency of products, improves the production efficiency of cochlear implants, and reduces the production cost of enterprises. Particularly, the effect is more prominent after the advantages of a precision processing technology and a laser processing technology are fully utilized.
Drawings
Figures 1-9 are schematic views showing the steps of one embodiment of a cochlear implant electrode keel fabrication method of the present invention;
FIG. 10 is a schematic structural view of a pressing fixture according to the above embodiment of the present invention;
FIG. 11 is an enlarged view of the notch of the above embodiment of the present invention;
FIG. 12 is an enlarged view of the electrode contact according to the above embodiment of the present invention;
figure 13 is an enlarged schematic view of the electrode keel in the above embodiment of the invention;
FIG. 14 is a schematic diagram of three electrode arrays that can be processed by the cochlear implant electrode array obtained by the method of the present invention.
Description of the element reference numerals
1. Electrode contact
2. Cantilever arm
3. Cross beam
4. Micro-pores
5. Electrode wire
50. Electrode filament bundle
6. Solder joint
7U type bend
8. Pressing jig module I
9. Pressing jig module II
10. Notch opening
11. Electrode keel
12. Straight electrode
13. Micro-bending electrode
14. Pre-bent electrode
15. Electrode grid
16. Pressing jig
Detailed Description
The following description of the embodiments of the present invention is provided for illustrative purposes, and other advantages and effects of the present invention will become apparent to those skilled in the art from the present disclosure.
It should be understood that the structures, ratios, sizes, and the like shown in the drawings are only used for matching the disclosure of the present disclosure, and are not used for limiting the conditions that the present disclosure can be implemented, so that the present disclosure is not technically significant, and any structural modifications, ratio changes or size adjustments should still fall within the scope of the present disclosure without affecting the efficacy and the achievable purpose of the present disclosure. In addition, the terms "upper", "lower", "left", "right", "middle" and "one" used in the present specification are for clarity of description, and are not intended to limit the scope of the present invention, and the relative relationship between the terms and the terms is not to be construed as a scope of the present invention.
The cochlear implant electrode array prepared by the method comprises a plurality of electrode contacts, each electrode contact is connected with an electrode wire, the electrode contacts are sequentially arranged front and back along the implantation direction of the cochlear implant electrode to form the cochlear implant electrode array, and the cochlear implant electrode array is packaged into a whole by a colloidal silica. The surface of the electrode contact is exposed outside the silica gel body, and the electrode contact as well as the electrode wire and the electrode wire are insulated from each other.
Figures 1-9 illustrate one embodiment of a cochlear implant electrode keel fabrication method provided by the present invention. The preparation method comprises the following steps:
the electrode grid processing step, as shown in fig. 1, is to make the electrode grid through a punching or cutting process, the used raw material can be a platinum plate or a platinum iridium alloy plate, the electrode grid comprises electrode contacts 1 arranged at equal distance from left to right, each electrode contact 1 is connected with two beams 3 through two cantilevers 2, the electrode contacts 1 are preferably arranged in a staggered manner in the arrangement direction, that is, each electrode contact 1 comprises a long cantilever and a short cantilever, and the long cantilever and the short cantilever of two adjacent electrode contacts 1 are alternately arranged, so that the later shaping and center adjustment are facilitated. The stamping process preferably adopts a precision stamping process to improve the processing precision, and the cutting process can be a laser cutting process.
And a micro-hole processing step of processing a micro-hole 4 at one end of the electrode contact as shown in fig. 2. The machining position of the micro-hole 4 is preferably near one end of the short cantilever. Because the aperture of the micropore is smaller, the diameter is generally less than 0.1mm, the laser drilling process is preferably adopted for micropore processing, the precision of the laser drilling process is high, the processed aperture is small, no flash or burr exists, the welding of the electrode wire at the later stage is facilitated, and the damage effect on the electrode wire and the insulating coating thereof is avoided.
In the wire electrode welding step, as shown in fig. 3, one end of the wire electrode 5 is inserted through the micro-hole of the electrode contact, the remaining wire electrode is left at the left side of the electrode contact, and the cantilever (in this embodiment, the short cantilever) at the side close to the micro-hole is disconnected from the electrode contact, for example, by a laser cutting process or cutting with a special cutter. As shown in fig. 4 and 5, the electrode contact is folded from one end of the disconnection cantilever to the other end, and then the wire electrode and the electrode contact are welded together. The electrode contact is prevented from being opened accidentally in the later operation, and the overlapping positions of the folded ends of the electrode contact are preferably welded together at the same time. The position of the welding spot 6 is shown in fig. 5. The welding is preferably a laser welding process. The part of the electrode wire exposed from the micro-hole is flattened by laser during welding.
And a wire electrode bending step of bending the wire electrode positioned at the left side of the electrode contact 180 degrees from the upper side of the electrode contact to the right side as shown in fig. 6. The electrode wire forms U-shaped bend 7 at the left part of the electrode contact, and when the electrode wire is pulled by external force, the U-shaped bend 7 can effectively relieve stress and protect the connection reliability of welding spots.
And a wire electrode bundling step, as shown in fig. 7, repeating the wire electrode welding step and the wire electrode bending step, completing the welding of all electrode contacts and the wire electrodes, and gathering all the wire electrodes together to form an electrode wire bundle 50.
And in the electrode keel forming step, as shown in fig. 8 and 9, the electrode grid 15 is placed on a pressing jig 16, the pressing jig comprises a first pressing jig module 8 and a second pressing jig module 9, a plurality of notches are formed between the first pressing jig module 8 and the second pressing jig module 9 after the first pressing jig module 8 and the second pressing jig module 9 are combined (see the schematic structural diagram of the pressing jig in fig. 10 and the enlarged notch image shown in fig. 11), and the notch interval is the same as the electrode contact interval. And (3) respectively corresponding electrode contacts of the electrode grid placed on the pressing jig to the notches, pressing the electrode contacts into groove shapes, such as C-shaped grooves (see the enlarged view of the C-shaped grooves shown in fig. 11), positioning the electrode tows in the C-shaped grooves of the electrode contacts, disconnecting all the cantilevers from the electrode contacts to form electrode keels 11 (see the enlarged view of the electrode keels 11 shown in fig. 12), coating a proper amount of silica gel in the electrode keels 11, solidifying, separating the first module from the second module, and taking out the electrode keels 11. The proper amount of silica gel is enough to integrate all electrode contacts after all cantilevers are disconnected, and the shaping of a later-period packaging electrode is not influenced.
As shown in fig. 13, on the basis of the above-mentioned electrode keel preparation method, the electrode keel can be placed in different electrode packaging molds according to the processing requirements to be made into a straight electrode array 12, a slightly bent electrode array 13, a pre-bent electrode array 14, and the like.
By the method, the general cochlear implant electrode keel can be prepared, is suitable for cochlear implant electrodes of different shapes, improves the consistency of products, improves the production efficiency of cochlear implants, and reduces the production cost of enterprises. Particularly, the effect is more prominent after the advantages of a precision processing technology and a laser processing technology are fully utilized.
The foregoing embodiments are merely illustrative of the principles and utilities of the present invention and are not intended to limit the invention. Those skilled in the art can modify or change the above-described embodiments without departing from the spirit and scope of the present invention. Accordingly, it is intended that all equivalent modifications or changes which can be made by those skilled in the art without departing from the spirit and technical spirit of the present invention be covered by the claims of the present invention.
Claims (10)
1. A preparation method of an artificial cochlea electrode keel is characterized by comprising the following steps:
and (3) processing an electrode grid: manufacturing an electrode grid by a stamping process or a cutting process, wherein the electrode grid comprises electrode contacts which are arranged at a certain interval, and two ends of each electrode contact are respectively connected with two beams through cantilevers;
and (3) micropore processing: processing a micropore at one end of the electrode contact;
welding electrode wires: the connecting end of the electrode wire penetrates through the micropore, the free end of the electrode wire is positioned on one side of the electrode contact, one end of the electrode contact with the micropore is disconnected with the cantilever, one end of the electrode contact with the micropore is folded towards the other end of the electrode contact, and the connecting end of the electrode wire and the electrode contact are welded together;
a wire electrode bundling step: repeating the electrode wire welding step, and collecting all the electrode wires together to form an electrode wire bundle after welding all the electrode contacts and the electrode wires;
forming the electrode keel: placing the electrode grid on a pressing jig, the pressing jig comprises a first module and a second module, a plurality of notches are formed between the first module and the second module after the first module and the second module are combined, the interval between the notches is matched with the interval between electrode contacts on the electrode grid, each electrode contact placed on the pressing jig corresponds to the notch respectively, the electrode contacts are pressed into the notches to be made into groove shapes, all cantilevers and the electrode contacts are disconnected to form electrode keels, proper silica gel is coated in the electrode keels and solidified, then the first module and the second module are separated, and the electrode keels are taken out.
2. The method for preparing a cochlear implant electrode keel according to claim 1, wherein:
each electrode contact on the electrode grid comprises a long cantilever and a short cantilever, the long cantilevers and the short cantilevers of the two adjacent electrode contacts are alternately arranged, and the micropores are formed at one end, close to the short cantilevers or the long cantilevers, of the electrode contacts.
3. The method for preparing a cochlear implant electrode keel according to claim 1, wherein:
the stamping process is a precise stamping process.
4. The method for preparing a cochlear implant electrode keel according to claim 1, wherein:
the processing of the micropores adopts a laser drilling process.
5. The method for preparing a cochlear implant electrode keel according to claim 1, wherein:
the cutting process is a laser cutting process.
6. The method for preparing a cochlear implant electrode keel according to claim 1, wherein:
and the connecting end of the electrode wire penetrates through the upper part of the micropore, and after the connecting end of the electrode wire and the electrode contact are welded together, the electrode wire is bent by 180 degrees from one side of the electrode contact to the other side of the electrode contact from the upper part of the electrode contact.
7. The method for preparing a cochlear implant electrode keel according to claim 1, wherein:
the electrode wire welding step further comprises welding the overlapping positions of the folded two ends of the electrode contact together.
8. The cochlear implant electrode keel preparation method according to claim 1 or 7, wherein:
the welding adopts a laser welding process.
9. The method for preparing a cochlear implant electrode keel according to claim 1, wherein:
the cantilever is disconnected from the electrode contact by a laser cutting process.
10. A method for preparing an artificial cochlea electrode array union is characterized by comprising the following steps:
the electrode keel prepared by the method for preparing the cochlear implant electrode keel according to any one of claims 1-9 is placed in an electrode packaging mold to prepare a cochlear implant electrode array.
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| CN201711478516.7A CN109985307B (en) | 2017-12-29 | 2017-12-29 | Artificial cochlea electrode keel and electrode array manufacturing method |
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| CN201711478516.7A CN109985307B (en) | 2017-12-29 | 2017-12-29 | Artificial cochlea electrode keel and electrode array manufacturing method |
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| CN109985307A CN109985307A (en) | 2019-07-09 |
| CN109985307B true CN109985307B (en) | 2022-12-13 |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6266568B1 (en) * | 1998-06-02 | 2001-07-24 | Advanced Bionics Corporation | Inflatable cochlear electrode array and method of making same |
| US6309410B1 (en) * | 1998-08-26 | 2001-10-30 | Advanced Bionics Corporation | Cochlear electrode with drug delivery channel and method of making same |
| CN101970041A (en) * | 2007-11-16 | 2011-02-09 | 耳蜗有限公司 | Electrode array and method of forming an electrode array |
| CN106794342A (en) * | 2014-06-17 | 2017-05-31 | 先进仿生学股份公司 | Torsion-resistant electrode assemblies for cochlear leads |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7315763B2 (en) * | 2002-09-19 | 2008-01-01 | Advanced Bionics Corporation | Cochlear implant electrode and method of making same |
| WO2005055363A1 (en) * | 2003-12-08 | 2005-06-16 | Cochlear Limited | Cochlear implant assembly |
| US20110071596A1 (en) * | 2007-11-19 | 2011-03-24 | Sule Kara | Electrode contacts for a medical implant |
| US8515557B2 (en) * | 2007-11-19 | 2013-08-20 | Cochlear Limited | Electrode array for a cochlear implant |
| WO2009079704A1 (en) * | 2007-12-21 | 2009-07-02 | Cochlear Limited | Electrode array assembly |
-
2017
- 2017-12-29 CN CN201711478516.7A patent/CN109985307B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6266568B1 (en) * | 1998-06-02 | 2001-07-24 | Advanced Bionics Corporation | Inflatable cochlear electrode array and method of making same |
| US6309410B1 (en) * | 1998-08-26 | 2001-10-30 | Advanced Bionics Corporation | Cochlear electrode with drug delivery channel and method of making same |
| CN101970041A (en) * | 2007-11-16 | 2011-02-09 | 耳蜗有限公司 | Electrode array and method of forming an electrode array |
| CN106794342A (en) * | 2014-06-17 | 2017-05-31 | 先进仿生学股份公司 | Torsion-resistant electrode assemblies for cochlear leads |
Non-Patent Citations (1)
| Title |
|---|
| 人工耳蜗电极设计策略和临床应用;辜萍 等;《中华耳科学杂志》;20161231;第14卷(第2期);第282-286页 * |
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