CN109966442A

CN109966442A - A kind of Chinese medicine composition given orally or externally and preparation method thereof for treating ulcerative colitis

Info

Publication number: CN109966442A
Application number: CN201910324889.1A
Authority: CN
Inventors: 杨倩; 徐伟超; 刘建平; 李博林
Original assignee: Individual
Current assignee: Individual
Priority date: 2019-04-22
Filing date: 2019-04-22
Publication date: 2019-07-05
Anticipated expiration: 2039-04-22
Also published as: CN109966442B

Abstract

A kind of Chinese medicine composition given orally or externally for treating ulcerative colitis, including oral traditional Chinese medicine composition and external medicine composition；Oral traditional Chinese medicine composition includes the Chinese medicine composition of following parts by weight: 13-17 parts of wrinkled giant hyssop, 10-13 parts of eupatorium, 18-22 parts of oriental wormwood, 28-32 parts of talcum, 7-11 parts of scorpio, 7-11 parts of ground bettle, 13-17 parts of the root of Dahurain angelica, 7-11 parts of radix saposhnikoviae, 10-13 parts of red halloysite, 10-13 parts of kaolinite, 7-11 parts of kuh-seng, 13-17 parts of Radix Isatidis, 7-11 parts of Divine Comedy, 7-11 parts of red yeast rice, 7-11 parts of fructus amomi, 4-8 parts of nutmeg；External medicine composition is identical with oral traditional Chinese medicine composition ingredient；The invention also includes the preparation methods of the Chinese medicine composition given orally or externally for the treatment of ulcerative colitis, and the present invention is based on innovation theories of traditional Chinese medical science --- and turbid poison theory treats ulcerative colitis with turbid disintoxication is changed.

Description

A kind of Chinese medicine composition given orally or externally and preparation method thereof for treating ulcerative colitis

Technical field

The present invention relates to technical field of traditional Chinese medicines, and in particular to a kind of oral administration and externally Chinese traditional medicine composition for treating ulcerative colitis Object and preparation method thereof.

Background technique

Ulcerative colitis (ulcerative colitis, UC) is a kind of colon that the cause of disease is not still fully aware of and straight Intestines chronic nonspecific inflammation disease, lesion are confined to intestinal mucosa and intestinal mucosa lower layer, are in inflammation state, multidigit In sigmoid colon, rectum, colon descendens, or even entire colon is expanded to, the course of disease is very long, is spy with breaking-out, alleviation, recurrent exerbation Point.It is found in any age, age of onset is in " bimodal shape ", most common with 20~30 years old, the strong influence body of patient Health and social life, are one of difficult treatments of digestive system.Common clinical manifestation is diarrhea, mucus pus and blood stool, abdominal pain, after an action of the bowels Alleviation, tenesmus, fever, anaemia, out of strength, joint injury, erythema nodosum etc..Doctor trained in Western medicine clinical treatment is complicated, mostly uses ammonia Base Salicylic Acid Formulations, glucocorticoid, immunosuppressor, biological agent etc., have some limitations and toxic side effect, expense Height, Relapse rate.

Summary of the invention

To solve the above problems, the present invention provides a kind of integrally-regulated enteron aisle, the state of an illness can be effectively relieved, recurrence rate is low, The Chinese medicine composition given orally or externally and preparation method thereof of the treatment ulcerative colitis of Small side effects.

Technical solution of the present invention:

A kind of Chinese medicine composition given orally or externally for treating ulcerative colitis, including oral traditional Chinese medicine composition and external application Chinese medicine combination Object；

Oral traditional Chinese medicine composition includes the Chinese medicine composition of following parts by weight: 13-17 parts of wrinkled giant hyssop, 10-13 parts of eupatorium, oriental wormwood 18- 22 parts, 28-32 parts of talcum, 7-11 parts of scorpio, 7-11 parts of ground bettle, 13-17 parts of the root of Dahurain angelica, 7-11 parts of radix saposhnikoviae, red halloysite 10-13 Part, 10-13 parts of kaolinite, 7-11 parts of kuh-seng, 13-17 parts of Radix Isatidis, 7-11 parts of Divine Comedy, 7-11 parts of red yeast rice, 7-11 parts of fructus amomi, meat 4-8 parts of cardamom；

External medicine composition includes the Chinese medicine composition of following parts by weight: 13-17 parts of wrinkled giant hyssop, 10-13 parts of eupatorium, oriental wormwood 18- 22 parts, 28-32 parts of talcum, 7-11 parts of scorpio, 7-11 parts of ground bettle, 13-17 parts of the root of Dahurain angelica, 7-11 parts of radix saposhnikoviae, red halloysite 10-13 Part, 10-13 parts of kaolinite, 7-11 parts of kuh-seng, 13-17 parts of Radix Isatidis, 7-11 parts of Divine Comedy, 7-11 parts of red yeast rice, 7-11 parts of fructus amomi, meat 4-8 parts of cardamom.

Further, oral traditional Chinese medicine composition includes the Chinese medicine composition of following parts by weight: 15 parts of wrinkled giant hyssop, 12 parts of eupatorium, 20 parts of oriental wormwood, 30 parts of talcum, 9 parts of scorpio, 9 parts of ground bettle, 15 parts of the root of Dahurain angelica, 9 parts of radix saposhnikoviae, 12 parts of red halloysite, 12 parts of kaolinite, hardship Join 9 parts, 15 parts of Radix Isatidis, 9 parts of Divine Comedy, 9 parts of red yeast rice, 9 parts of fructus amomi, 6 parts of nutmeg；

External medicine composition includes the Chinese medicine composition of following parts by weight: 15 parts of wrinkled giant hyssop, 12 parts of eupatorium, 20 parts of oriental wormwood, talcum 30 parts, 9 parts of scorpio, 9 parts of ground bettle, 15 parts of the root of Dahurain angelica, windproof 9 parts, 12 parts of red halloysite, 12 parts of kaolinite, 9 parts of kuh-seng, Radix Isatidis 15 parts, 9 parts of Divine Comedy, 9 parts of red yeast rice, 9 parts of fructus amomi, 6 parts of nutmeg.

Further, the preparation method of Chinese medicine composition, the preparation method of oral traditional Chinese medicine composition the following steps are included:

(1) above-mentioned parts by weight wrinkled giant hyssop, eupatorium, oriental wormwood, talcum, scorpio, ground bettle, the root of Dahurain angelica, radix saposhnikoviae, red halloysite, kaolinite, hardship are taken Ginseng, Radix Isatidis, Divine Comedy, red yeast rice, fructus amomi, nutmeg；

(2) radix saposhnikoviae is taken, is fried with 80 DEG C of mild fire to Mao Qingyan, medicine materical crude slice is cooled in buff, micro- Jiao Weidu, taking-up；

(3) red halloysite, kaolinite are put into clear water and are impregnated 1.5 hours, clear water did not had 2 centimetres of red halloysite, kaolinite, after immersion High heat decoction 0.5 hour；

(4) talcum in step (1) is added into the medical fluid of step (3), talcum is placed in the dilute cotton cloth bag of primary colors and is carried out It decocts, is decocted 0.5 hour after boiling；

(5) into the medical fluid of step (4) be added step (1) in wrinkled giant hyssop, eupatorium, oriental wormwood, scorpio, ground bettle, the root of Dahurain angelica, radix saposhnikoviae, Kuh-seng, Radix Isatidis, Divine Comedy, red yeast rice decoct 0.5 hour after boiling；

(6) it is added into the medical fluid of step (5) and smashes the fructus amomi for 0.5 cubic centimetre, nutmeg, decocted 15 minutes, take advantage of after boiling Heat filtering obtains filtrate, and the dregs of a decoction add the water of 15 times of dregs of a decoction parts by weight to decoct filtering in 1-1.5 hours, and merging obtains filtrate twice and obtains Mixed filtrate；

(7) after the mixed filtrate that step (6) obtains being heated to 70 DEG C, clear solution is obtained by filtration, is filled in container, 121 DEG C, 20 minutes normal-pressure sterilizations.

The preparation method of external medicine composition the following steps are included:

(2) radix saposhnikoviae is taken, is fried with 80 DEG C of mild fire to Mao Qingyan, medicine materical crude slice is in buff, and taking-up cools；

(4) into the medical fluid of step (3) be added step (1) in wrinkled giant hyssop, eupatorium, oriental wormwood, scorpio, ground bettle, the root of Dahurain angelica, radix saposhnikoviae, Kuh-seng, Radix Isatidis, Divine Comedy, red yeast rice decoct 0.5 hour after boiling；

(5) it is added into the medical fluid of step (4) and smashes the fructus amomi for 0.2 cubic centimetre, nutmeg, decocted 15 minutes, take advantage of after boiling Heat filtering obtains filtrate, and the dregs of a decoction add the water of 15 times of dregs of a decoction parts by weight to decoct filtering in 1-1.5 hours, and merging obtains filtrate twice and obtains Mixed filtrate；

(6) talcum is taken, powder processed sieves with 100 mesh sieve, obtains talcum powder, takes after mixing it with water in the mixed filtrate that (5) obtain；

Further, the dilute cotton cloth bag of step (4) primary colors in the preparation method of oral traditional Chinese medicine composition is hospital gauze Cloth bag.

Wrinkled giant hyssop: acrid flavour, warm-natured, returns spleen, stomach, lung channel.Having is turbid to be amusing, and wards off poison in, and the function that relieving summer-heat is delivered is used for turbid poison Middle resistance, abdominal fullness and distention, damp-warm syndrome are from the beginning of, vomiting, diarrhea, summer-heat and damp, fever with chilliness, fever with aversion to cold, chest distress etc.." materia medica " Record: " delicate fragrance tepor is apt to the reason wet turbid sputum in Central Region, for outer stomach of being amusing, vibrates clear positive quality goods ... cholera pain in the chest and abdomen person, wet turbid Retardance, the gas for injuring the clear sun of spleen soil is then suddenly formal confused, and vomiting and diarrhoea colic pain, fragrance can help Central Region clean air, win it is wet ward off dirty, therefore be summer-heat and damp Seasonal key medicine." modern pharmacology research confirm, wrinkled giant hyssop have adjust gastrointestinal function, anti-inflammatory and antibacterial, analgesia with it is antipyretic, only The effects of cough resolving sputum.

Eupatorium: acrid flavour, mild-natured, returns spleen, stomach, lung channel.It eliminates dampness with aromatics, appetizing of being amusing delivers the function of relieving summer-heat, for wet turbid Middle resistance, gastral cavity ruffian evil of vomitting, sweet, halitosis in mouth, polysialia, summer-heat and damp table disease, alliteration are uncomfortable in chest etc..Shennong's Herbal is recorded: " fragrant thoroughwort, Acrid flavour, puts down, and main dredging water passages kill disease due to noxious agents produced by various parasites, eliminating turbid pathogens, long term usage QI invigorating, not always, being proficient in the law of natural movement." modern pharmacology research confirmation, eupatorium Chemical component multiplicity has the multiple pharmacological effects such as anti-inflammatory, antitumor, is clinically used for diarrhea, infantile rotavirus enteritis, hat The illnesss such as heart trouble, summer-heat damp cold.

Oriental wormwood: bitter, pungent, cold nature, returns spleen, stomach, liver, gallbladder channel.There is the function of clearing away damp-heat, removing jaundice subcutaneous ulcer, be used for damp-warm syndrome summer-heat and damp, Jaundice oliguria, itchy sore etc..Shennong's Herbal is recorded: " main rheumatism fever and chills perverse trend, heat knot jaundice." modern pharmacology research It confirms, various of monomer contained by oriental wormwood or chemical composition have antalgic and inflammation relieving, anti-oxidant, antiviral, immunological regulation and resist swollen The pharmacological actions such as tumor.

Talcum: it is sweet in flavor, light, it is cold in nature, return bladder meridian, lung channel, stomach meridian.There is the function of inducing diuresis for treating strangurtia, clearing away summerheat, external application can dispel Wet sore.For diarrhea due to damp-heat, difficult urination, leaching drips puckery pain, and hot summer weather polydipsia, damp-warm syndrome is uncomfortable in chest, eczema etc.." a supplement to augmented materia medica " Record: " eliminating dampness, diversion channel, real large intestine, helping digestion poison, row is stagnant, and by blood coagulation, solution is dry thirsty, and the key medicine of internal heat drops in tonifying spleen and stomach." existing Show that talcum powder external application is woven with protective effect to inflammation or damaged skin group for pharmaceutical research, the gastrointestinal tract of inflammation can be protected Mucous membrane and antidiarrheal is spat in town.In addition, talcum powder has certain inhibiting effect to typhoid bacillus, paratyphosum Bacterium and meningococcus.

Scorpio: acrid flavour, mild-natured, return liver warp.There are relieving convulsion and spasm, detoxicating and resolving a mass, the function removed obstruction in channels to relieve pain.For sore swell and ache curative, Scrofula tuberculosis, anxious chronic infantile convulsion, facial paralysis, tetanus, migraine and general headache, rheumatic arthralgia etc.." beautiful Chinese catalpa medicine solution " is recorded: " scorpion wears muscle It is deep, wind is removed by wet." modern pharmacology research shows that scorpio has analgesia, the effect of antitumor, inhibition thrombosis.

Ground bettle: taste is salty, mild-natured, return liver warp.There are scattered blood stasis, the heavily fortified point that disappears to tie, the function of continuous muscles and bones.For addiction lump in the abdomen lump in the abdomen, bruise Damage, injury of tendon and muscle fracture etc.." General Records of Holy Universal Relief " is recorded: " controlling fistula sore swells, dry eupolyphoge sinensis end, Moschus are respectively ground a little.Upper two taste, grinds well.It is dry It mixes or pastes, control it with dry and wet." modern pharmacology research show in ground bettle containing amino acid, protein, ucleosides (urine it is phonetic Pyridine, allantoin etc.), fatty acid, alkaloid, a variety of chemical components such as microelement, have anticoagulation, thrombus, it is antitumor, Promote union, adjust the very extensive pharmacological actions such as blood lipid, anti-mutation, resist oxygen lack.

The root of Dahurain angelica: acrid flavour, slight bitter is warm-natured, returns stomach, large intestine, lung channel.There are myogenic pain relieving, apocenosis of invigorating blood circulation, the function of wind-damp dispelling.With In intestines wind anal fistula, ulcer sores, headache, toothache, nasosinusitis, leukorrhea with reddish discharge, pruitus etc.." Bie Lu " is recorded: " it is long to treat ailment said due to cold or exposure It rushes down, vomits, fullness sensation in bilateral hypochondrium, wind pain dizzy, eye itching." modern pharmacology research show the main chemical compositions in the root of Dahurain angelica be cumarin Class and volatile oil have the effects that analgesia, antipyretic, anti-inflammatory, and can improve local blood circulation, eliminate toxin mistake in the tissue Degree accumulation, promotes cell metabolism.

Radix saposhnikoviae: acrid flavour, sweet, slightly warm in nature return bladder, lung, spleen, Liver Channel.There is expel endogenous wind to relieve convulsion, expels pathogenic wind from the body surface, the function of relieving convulsion.With In the insufficiency of the spleen with overabundance of dampness, exogenous disease exterior syndrome, rubella itch, rheumatic arthralgia etc..Pungent scattered power weakens after radix saposhnikoviae stir-fry, and anti-diarrhea effect enhancing cures mainly Endless diarrhea." Bencao Jingshu " is recorded: " all disease deficiency of blood convulsions are anxious, have a headache not because of Yu Fenghan, and affection of cold is not wet for loose stool, and two constipation are puckery, Infantile spleen deficiency hair is jerked, and shies the chronic infantile convulsion due to dysfunction of the spleen slowly, and gas lift is felt sick, and fire rises hair and coughs, night sweat due to yin deficiency, the diseases such as spontaneous perspiration due to yang insufficiency, and Fa Suotong avoids." existing Show that the main active in radix saposhnikoviae includes chromone, cumarin, volatile oil etc. for pharmaceutical research, there is stronger town Bitterly, anti-inflammatory, antitumor, immunological regulation and antioxidation.

Red halloysite: it is sweet in flavor, sour, puckery, it is warm-natured, return stomach, large intestine channel.There are puckery intestines, stops blooding, the function of myogenic sore.For chronic diarrhea Protracted dysentery, fecal blood, metrorrhagia and metrostaxis leukorrhagia；It controls sore outside not hold back, eczema pus contamination etc.." Bie Lu " record: " treat abdominal pain let out it is out-of-the-way, under Dysentery is red white, small convenience and ulcer sore hemorrhoid, and woman's metrorrhagia leaks down, produces difficult, afterbirth and do not go out." modern pharmacology research shows red stone Rouge contains a large amount of alumina silicate, can adsorb toxin in the digestive tract, such as flora abnormal fermentation product and inflammatory exudate, and can cover Intestinal mucosa to reduce stimulation and movement to gastrointestinal tract, and has anastalsis to hemorrhage of gastrointestinal tract.

Kaolinite: sweet in flavor, sour, mild-natured, return lung, large intestine channel.There are puckery intestines, the function of hemostasis.For chronic diarrhea, protracted dysentery, metrorrhagia and metrostaxis band It is inferior." Bie Lu " is recorded: " supporting lung qi, thick intestines, Psoralen marrow is treated the five internal organs palpitation with fear deficiency, is tired of under the heart, only abdominal pain, is lauched, small intestine Bleach Hot semiliquid stool purulence blood, woman's metrorrhagia and metrostaxis are red white fertile." modern pharmacology research show kaolinite main component be aluminium silicate hydrate, Silicon oxide-containing 46.5%, aluminium oxide 39.5%, water 14.0%.Alimentary canal toxin can be effectively adsorbed, intestinal mucosa is covered, reduces enteron aisle thorn Swash and moves.

Kuh-seng: bitter, cold in nature, return heart, liver, stomach, large intestine, bladder meridian.There are heat-clearing and damp-drying drug, desinsection, the function of diuresis.For heat Dysentery, hematochezia, jaundice urodialysis, leukorrhea with reddish discharge, eczema, wet sore, pruitus, castor etc.." Bie Lu " is recorded: " removing latent heat intestines Bleach quenches the thirst, and sobers up, and urine Huang also, treats malignant sore lower part and hides, flat stomach gas makes us addiction." modern pharmacology research shows that kuh-seng is raw Alkaloids class and flavone compound play the principle active component of various effects for it, have protection intestinal mucosa, anti-inflammatory, disease-resistant Poison, resisting pathogenic microbes, antiulcer and the multiple pharmacological effects such as antipyretic.

Radix Isatidis: bitter, cold in nature, return heart, stomach meridian.There are clearing heat and detoxicating, cool blood, the function of relieving sore-throat.For carbuncle swells, epidemic heat syndrome hair Spot, mumps, scarlet fever, major part pestilence, erysipelas etc.." book on Chinese herbal medicine just read " is recorded: " Radix Isatidis, that is, indigo-blue, function nature and flavor with Indigo-blue leaf is same, can enter liver stomach blood system, but heat-clearing, detoxifies, wards off epidemic disease, desinsection.But leaf master dissipates, the main drop of root, this is again same In different ear." modern pharmacology research shows Radix Isatidis to hay bacillus, staphylococcus aureus, sarcine, large intestine bar The various bacterias such as bacterium have inhibiting effect, and have certain immunological regulation and antitumaous effect.

Divine Comedy: sweet in flavor, pungent, warm-natured, returns spleen, stomach meridian.There are strengthening the spleen and stomach, the function of promoting digestion and removing indigestion.For vomiting dysentery, diet It stagnates, indigestion, abdominal fullness and distention, loss of appetite etc..Compendium of Material Medica is recorded: " help digestion lower gas, and it is swollen to let out dysentery against cholera for eliminating phlegm Full all diseases, function are same with song." modern pharmacology research shows that Divine Comedy ingredient includes volatile oil, glucoside, fat oil and vitamin B Deng, pass through and aoxidizes energy supply, digestion and absorption and utilization of the promotion human body to food protein.

Red yeast rice: sweet in flavor, slightly warm in nature, returns spleen, large intestine, Liver Channel.There are reinforcing spleen to promote digestion, the function of activating microcirculation and removing stasis medicinal.For red white diarrhea, Eating accumulation, abdominal fullness and distention, prolonged lochia, traumatic injury etc.." a supplement to augmented materia medica " is recorded: " promoting blood circulation helps digestion, and invigorating the spleen is warm Stomach, trough under dysentery." modern pharmacology research shows that red yeast rice is rich in numerous nutrients, wherein enriched the most with irony, Therefore the effect of enriching blood and preventing anaemia.And it includes phosphorus abundant, vitamin A, B crowd can then improve malnutritive, spirit not The symptoms such as vibration.The substances such as contained pantothenic acid, vitamin E, gluathione Teng's amino acid, then play the role of cancerocidal substance, especially to prevention The effect of colon cancer becomes apparent.

Fructus amomi: acrid flavour, warm-natured, returns spleen, stomach, kidney channel.There are warming spleen and stopping diarrha, dampness elimination appetizing, the function of regulating the flow of vital energy and preventing miscarriage.For wet Turbid middle resistance, gastral cavity ruffian is not hungry, deficiency-cold in spleen and stomach, vomiting and diarrhea etc.." jade seizes medicine solution " is recorded: " and middle regulating the qi flowing in the channels, strongly fragrant stagnant, the drop stomach-Yin that disappears of row And lower food, change paddy up to spleen yin, vomiting is all good with diarrhea, coughs all wonderful with phlegm retention.The sour of the part of the body cavity above the diaphragm housing the heart and lungs is adjusted, gas is foul under benefit. Turbid drop is risen clearly, and full Lai Zhongqi, middle gas is non-prosperous, then pivot does not turn, and it is inverse that spleen falls into meaning." modern pharmacology research shows fructus amomi master containing waving Hair oil, such as Bronyl acetate, camphor, lauro lene, limonene still contain flavones ingredient.With anti-inflammatory, analgesia, antidiarrheal, antibacterial, Adjust flora, anti-oxidant, stomach and intestine defencive function.

Nutmeg: acrid flavour, bitter, warm-natured, returns spleen, stomach, large intestine channel.There are the puckery intestines of middle benefit gas, the function of promoting the circulation of qi helps digestion.It is rushed down for void cold Dysentery, abdominal distention, deficiency of food vomiting, place food do not disappear." Japan hanako materia medica " is recorded: " in tune, lower gas, antidiarrheal dysentery whets the appetite, helps digestion. The outer network of skin, lower gas, relieving alcoholism control cholera." modern pharmacology research shows that nutmeg has antibacterial, anti-inflammatory, anti-oxidant, anti- A variety of pharmacological activities such as cancer, liver protection, reducing blood sugar and blood lipid.

Beneficial effects of the present invention:

The present invention is based on innovation theories of traditional Chinese medical science --- and turbid poison theory treats ulcerative colitis with turbid disintoxication is changed.Chinese medicine has no Ulcerative colitis name of disease is attributed to the models such as " dysentery ", " diarrhea ", " hematochezia ", " intestines Bleach ", " acute temesmus " according to its symptom mostly Farmland.Disease discussion sees " a Plain Questions sun yin-yang piece " earliest, says: " eating and drinking without temperance, daily life frequently, it is negative by it ... it is negative by Then enter the five internal organs ... enter the five internal organs Ze Anger and completely occlude, under let out for supper, be long intestines Bleach ", " Plain Questions to very to discuss greatly " is added: " few Victory ... the pain and distention of the abdomen of yin, loose stool, it is red fertile for passing "." doctor's mirror at all times " is said: " husband intestines Bleach person, lower blood of defecating.

This disease differentiation of symptoms and signs for classification of syndrome is not yet unified, and the interpretation of the cause, onset and process of an illness is mostly spleen deficiency, liver depression, food stagnation etc..Contemporary doctor scholar is mostly from strong In spleen peace, soothing liver-qi stagnation, the methods of promoting digestion set about, in conjunction with clinical report, curative effect is also substantially similar.We are according to many decades Clinical experience, it is believed that turbid poison served in the occurrence and development of this disease it is vital, Gu and it is off the beaten track, around turbid poison it is dialectical This disease is treated, takes orally with external application and with Tongfang, obtains good curative effect.

Wrinkled giant hyssop, eupatorium, oriental wormwood, talcum resolving turbidity and eliminating dampness in side, draw it is turbid go out from urine, be monarch drug in a prescription；Scorpio, ground bettle, kuh-seng, Radix Isatidis removing toxic substances is simultaneous with heat-clearing, is ministerial drug；The puckery intestines hemostasis of the root of Dahurain angelica, radix saposhnikoviae, red halloysite, kaolinite, myogenic sore, and monarch can be helped Minister, to reach the function of regulating functional activities of qi, is adjutant with expelling wind drug characteristic；Fructus amomi, nutmeg, Divine Comedy, red yeast rice are warming spleen and stopping diarrha, and appetizing disappears Food, to make medicine.Full side's turbid removing toxic substances of playing altogether, and the function with promoting blood circulation and stopping pain, puckery intestines myogenic, in the peace that helps digestion.

Instructions of taking:

The instructions of taking of oral traditional Chinese medicine composition: the mixed liquor 300mL after taking sterilizing every time, point 2 empty stomach sub-services sooner or later.2 The moon is a cycle.

Invention Chinese medicine composition avoids the irritable foods such as greasy, pungent, raw and cold during taking.

The Enem-d method of external medicine composition: obtaining 150mL medical fluid by preparation method, sleeps the instillation operation that moves ahead, Patient empties the intestine before operating, and takes left lateral position, raises buttocks 10cm, fluid temperature is advisable with 39-42 DEG C.Paraffin oil lubrication anus Pipe front end, anal canal insertion depth be 10cm, drop speed for 50 drop/point.

Specific embodiment

Embodiment 1

Oral traditional Chinese medicine composition includes the Chinese medicine composition of following parts by weight: 13 parts of wrinkled giant hyssop, 10 parts of eupatorium, 18 parts of oriental wormwood, talcum 28 parts, 7 parts of scorpio, 7 parts of ground bettle, 13 parts of the root of Dahurain angelica, windproof 7 parts, 10 parts of red halloysite, 10 parts of kaolinite, 7 parts of kuh-seng, Radix Isatidis 13 parts, 7 parts of Divine Comedy, 7 parts of red yeast rice, 7 parts of fructus amomi, 4 parts of nutmeg；

External medicine composition includes the Chinese medicine composition of following parts by weight: 13 parts of wrinkled giant hyssop, 10 parts of eupatorium, 18 parts of oriental wormwood, talcum 28 parts, 7 parts of scorpio, 7 parts of ground bettle, 13 parts of the root of Dahurain angelica, windproof 7 parts, 10 parts of red halloysite, 10 parts of kaolinite, 7 parts of kuh-seng, Radix Isatidis 13 parts, 7 parts of Divine Comedy, 7 parts of red yeast rice, 7 parts of fructus amomi, 4 parts of nutmeg.

Embodiment 2

Oral traditional Chinese medicine composition includes the Chinese medicine composition of following parts by weight: 17 parts of wrinkled giant hyssop, 13 parts of eupatorium, 22 parts of oriental wormwood, talcum 32 parts, 11 parts of scorpio, 11 parts of ground bettle, 17 parts of the root of Dahurain angelica, windproof 11 parts, 13 parts of red halloysite, 13 parts of kaolinite, 11 parts of kuh-seng, plate 17 parts of blue root, 11 parts of Divine Comedy, 11 parts of red yeast rice, 11 parts of fructus amomi, 8 parts of nutmeg；

External medicine composition includes the Chinese medicine composition of following parts by weight: 17 parts of wrinkled giant hyssop, 13 parts of eupatorium, 22 parts of oriental wormwood, talcum 32 parts, 11 parts of scorpio, 11 parts of ground bettle, 17 parts of the root of Dahurain angelica, windproof 11 parts, 13 parts of red halloysite, 13 parts of kaolinite, 11 parts of kuh-seng, plate 17 parts of blue root, 11 parts of Divine Comedy, 11 parts of red yeast rice, 11 parts of fructus amomi, 8 parts of nutmeg.

Embodiment 3

Oral traditional Chinese medicine composition includes the Chinese medicine composition of following parts by weight: 14 parts of wrinkled giant hyssop, 12 parts of eupatorium, 19 parts of oriental wormwood, talcum 29 parts, 9 parts of scorpio, 8 parts of ground bettle, 16 parts of the root of Dahurain angelica, windproof 10 parts, 12 parts of red halloysite, 12 parts of kaolinite, 8 parts of kuh-seng, Radix Isatidis 14 parts, 9 parts of Divine Comedy, 9 parts of red yeast rice, 8 parts of fructus amomi, 5 parts of nutmeg；

External medicine composition includes the Chinese medicine composition of following parts by weight: 16 parts of wrinkled giant hyssop, 11 parts of eupatorium, 19 parts of oriental wormwood, talcum 29 parts, 8 parts of scorpio, 10 parts of ground bettle, 14 parts of the root of Dahurain angelica, windproof 8 parts, 11 parts of red halloysite, 12 parts of kaolinite, 9 parts of kuh-seng, Radix Isatidis 16 parts, 9 parts of Divine Comedy, 8 parts of red yeast rice, 8 parts of fructus amomi, 7 parts of nutmeg.

Embodiment 4

Oral traditional Chinese medicine composition includes the Chinese medicine composition of following parts by weight: 16 parts of wrinkled giant hyssop, 12 parts of eupatorium, 21 parts of oriental wormwood, talcum 31 parts, 10 parts of scorpio, 10 parts of ground bettle, 16 parts of the root of Dahurain angelica, windproof 10 parts, 12 parts of red halloysite, 11 parts of kaolinite, 10 parts of kuh-seng, plate 16 parts of blue root, 10 parts of Divine Comedy, 10 parts of red yeast rice, 10 parts of fructus amomi, 7 parts of nutmeg；

External medicine composition includes the Chinese medicine composition of following parts by weight: 16 parts of wrinkled giant hyssop, 12 parts of eupatorium, 19 parts of oriental wormwood, talcum 29 parts, 10 parts of scorpio, 10 parts of ground bettle, 16 parts of the root of Dahurain angelica, windproof 10 parts, 11 parts of red halloysite, 11 parts of kaolinite, 10 parts of kuh-seng, plate 16 parts of blue root, 10 parts of Divine Comedy, 10 parts of red yeast rice, 10 parts of fructus amomi, 7 parts of nutmeg.

Embodiment 5

Oral traditional Chinese medicine composition includes the Chinese medicine composition of following parts by weight: 14 parts of wrinkled giant hyssop, 14 parts of eupatorium, 20 parts of oriental wormwood, talcum 30 parts, 9 parts of scorpio, 9 parts of ground bettle, 15 parts of the root of Dahurain angelica, windproof 9 parts, 12 parts of red halloysite, 12 parts of kaolinite, 9 parts of kuh-seng, Radix Isatidis 15 parts, 9 parts of Divine Comedy, 9 parts of red yeast rice, 9 parts of fructus amomi, 6 parts of nutmeg；

External medicine composition includes the Chinese medicine composition of following parts by weight: 15 parts of wrinkled giant hyssop, 12 parts of eupatorium, 20 parts of oriental wormwood, talcum 30 parts, 9 parts of scorpio, 9 parts of ground bettle, 15 parts of the root of Dahurain angelica, windproof 9 parts, 12 parts of red halloysite, 12 parts of kaolinite, 9 parts of kuh-seng, Radix Isatidis 13-17 parts, 9 parts of Divine Comedy, 9 parts of red yeast rice, 9 parts of fructus amomi, 6 parts of nutmeg.

Embodiment 6

The preparation method of 1-5 of the embodiment of the present invention is equal are as follows:

The preparation method of oral traditional Chinese medicine composition the following steps are included:

(8) above-mentioned parts by weight wrinkled giant hyssop, eupatorium, oriental wormwood, talcum, scorpio, ground bettle, the root of Dahurain angelica, radix saposhnikoviae, red halloysite, kaolinite, hardship are taken Ginseng, Radix Isatidis, Divine Comedy, red yeast rice, fructus amomi, nutmeg；

(9) radix saposhnikoviae is taken, is fried with 80 DEG C of mild fire to Mao Qingyan, medicine materical crude slice is cooled in buff, micro- Jiao Weidu, taking-up；

(10) red halloysite, kaolinite are put into clear water and are impregnated 1.5 hours, clear water did not had 2 centimetres of red halloysite, kaolinite, impregnated High heat decoction 0.5 hour afterwards；

(11) into the medical fluid of step (3) be added step (1) in talcum, by talcum be placed in the dilute cotton cloth bag of primary colors into Row decocts, and decocts 0.5 hour after boiling；

(12) wrinkled giant hyssop in step (1), eupatorium, oriental wormwood, scorpio, ground bettle, the root of Dahurain angelica, anti-is added into the medical fluid of step (4) Wind, kuh-seng, Radix Isatidis, Divine Comedy, red yeast rice decoct 0.5 hour after boiling；

(13) it is added into the medical fluid of step (5) and smashes the fructus amomi for 0.5 cubic centimetre, nutmeg, decocted 15 minutes after boiling, Filtrate is obtained by filtration while hot, the dregs of a decoction add the water of 15 times of dregs of a decoction parts by weight to decoct filtering in 1-1.5 hours, and merging obtains filtrate twice and obtains To mixed filtrate；

(14) after the mixed filtrate that step (6) obtains being heated to 70 DEG C, clear solution is obtained by filtration, is filled in container, 121 DEG C, 20 minutes normal-pressure sterilizations.

(3) above-mentioned parts by weight wrinkled giant hyssop, eupatorium, oriental wormwood, talcum, scorpio, ground bettle, the root of Dahurain angelica, radix saposhnikoviae, red halloysite, kaolinite, hardship are taken Ginseng, Radix Isatidis, Divine Comedy, red yeast rice, fructus amomi, nutmeg；

(4) radix saposhnikoviae is taken, is fried with 80 DEG C of mild fire to Mao Qingyan, medicine materical crude slice is in buff, and taking-up cools；

(6) talcum is taken, powder processed sieves with 100 mesh sieve, obtains talcum powder, takes after mixing it with water in (5)；

Clinical application of the invention

1 materials and methods

1. 1 research object collects in June, -2015 in June, 2013 Hebei Prov. Traditional Chinese Medicine Hospital the spleen-stomach diseases section out-patient 110, adopt It is divided into treatment group 55 and control group 55 with random number method.Treatment group male 23, it is female 22, the age 19-64 years old, average (27.11 ± 2.3) year, the course of disease 1-18 years old, average (9.23 ± 1.3) year.Control group male 22, female 23, the age 20-63 years old, Average (28.3 ± 2.1) year, the course of disease 2-17 year old, be averaged (8.78 ± 1.2) year.The Baseline Data difference of control group and observation group without Statistical significance (P> 0.05), it is comparable.

1. 2 research drugs

1.2.1 treatment group gives oral traditional Chinese medicine composition: wrinkled giant hyssop 15g, eupatorium 12g, oriental wormwood 20g, talcum 30g, scorpio 9g, ground beetle Worm 9g, root of Dahurain angelica 15g, radix saposhnikoviae 9g, red halloysite 12g, kaolinite 12g, kuh-seng 9g, Radix Isatidis 15g, Divine Comedy 9g, red yeast rice 9g, fructus amomi 9g, nutmeg 6g.Day 1 dose, take 400 mL of juice decocting 2 times, it is point early, warmly take for evening 2 times.Give external medicine composition: wrinkled giant hyssop 15g, Eupatorium 12g, oriental wormwood 20g, talcum 30g(punching), scorpio 9g, ground bettle 9g, root of Dahurain angelica 15g, radix saposhnikoviae 9g, red halloysite 12g, kaolinite 12g, kuh-seng 9g, Radix Isatidis 15g, Divine Comedy 9g, red yeast rice 9g, fructus amomi 9g, nutmeg 6g.1 dose of day, according to the method system of embodiment 6 Standby product takes 150 mL of juice, sleeps the instillation operation that moves ahead, and patient empties the intestine before operating, and takes left lateral position, raises buttocks 10cm, Fluid temperature is advisable with 39-42 DEG C.Paraffin oil lubrication anal canal front end, anal canal insertion depth be 10cm, drop speed for 50 drop/point.

1.2.2 it is every to give Mesalazine enteric-coated tablet (Losan Pharma GmbH, registration certificate H20150124) for control group Secondary 2,3 times a day.

1.2.3 2 groups of the course for the treatment of treat 8 weeks after count curative effect.

1.3 case selection

1.3.1 Western medicine diagnostic criteria reference " diagnosis status of inflammatory bowel disease and the National Consensus for the treatment of (Guangzhou in 2012) ", in conjunction with Patients with clinical manifestations, colonoscopy and mucous membrane tissue check that 3 aspects are made a definite diagnosis.Tcm diagnosis standard is referring to " Chinese medicine Clinical Researches of New Drugs guideline (tentative) ".

1.3.2 it is included in standard and meets Western medicine diagnostic criteria among the above；Age 18-65 years old；Antibacterial is not used in nearly 1 month Anti-inflammatory and immunosupress class drug therapy；This test is voluntarily participated in, and signs informed consent form.

1.3.3 exclusion criteria accompanying infection property colitis, radiation colitis, ischemic colitis and Crohn disease Person；The severe complications persons such as concurrent rectal polyp, enterobrosis, intestinal obstruction, the carcinoma of the rectum；Concurrent severe primary disease patient；Gestation Person to be produced；Mentally disturbed.

1.4 observation index and method observe 2 groups of pretherapy and post-treatment clinical indices scoring variations, 1. symptom integral referring to " in Medicine Clinical Researches of New Drugs guideline (tentative) " in work out Quantitative marking standard, to the pretherapy and post-treatment cardinal symptom abdominal pain of patient, Diarrhea, pus and blood stool and minor symptom is tenesmus, burning sensation of the anus, abdominal distension, fever are scored, score value is higher, and symptom is more serious.Colonoscopy shows 0 point: mucous membrane image is shown normally；3 points: mucous membrane only shows the slight lesion such as hyperemia, and no bleeding occurs；6 points: There is granular variation in mucous membrane；9 points: there is hematostaxis and ulcer in mucous membrane.3. colonic tissue pathology ranking criterion is referring to " routed Ulcer colitis combination of Chinese tradiational and Western medicine diagnosis and treatment project (2003 Chongqing) ".0 point: mucosa lamina propria white blood cell count(WBC) 10/high power of < The mirror visual field (HP), a small amount of crypts involve；3 points: 10~50/HP of mucosa lamina propria white blood cell count(WBC), 50% or more crypts involve；6 Point: there is abscess in mucosa lamina propria white blood cell count(WBC) > 50/HP, crypts；12 points: ulcer and acute inflammation occur for mucosa lamina propria Disease reaction.Mayo activity index is referring to Mayo in " diagnosis status of inflammatory bowel disease and the National Consensus for the treatment of (Guangzhou in 2012) " Points-scoring system scores to the pretherapy and post-treatment defecation frequency of patient, hematochezia, endoscopic detection and doctor's overall assessment.Before and after treatment Patient's empty stomach peripheric venous blood is taken respectively, using enzyme linked immunosorbent assay (ELISA) (ELISA) method to patient's c reactive protein (CRP), red Cell settlement rate is detected, and carries out data record.

1.5 criterion of therapeutical effect complete incidence graphs: cardinal symptom completely disappears, and colonic mucosa returns to normal, Baron scope Scoring reduces 95% or more；Effective: cardinal symptom disappears substantially, colonic mucosa be improved significantly, Baron scope scoring reduce 70%-95%；Effective: cardinal symptom is improved, and colonic mucosa is improved, and the scoring of Baron scope reduces 30%- 70%；Invalid: main clinic symptoms and Baron endoscopy result are without improvement.

1.6 statistical method application SPSS, 20.0 statistical package carries out statistical analysis, measurement data mean ± standard deviation () indicates, is examined using t；The comparison of enumeration data rate uses X²It examines；Ranked data use rank sum test.WithP < 0.05 is that difference is statistically significant.

2 results

2.1 dropping situations treatment groups 55, fall off 4；It control group 55, falls off 3.

2.2 2 groups of curative effects are relatively shown in Table 1.

12 groups of curative effects of table compare, example (%)

Compared with the control group, *P< 0.05

Seen from table 1,2 groups of total effective rate comparing differences it is statistically significant (P< 0.05), treatment group's curative effect is better than control group.

2.2 2 groups of pretherapy and post-treatment clinical indices scorings, which are compared, is shown in Table 2.

22 groups of table pretherapy and post-treatment clinical indices scorings are compared, point

With this group before treatment, *P< 0.05；Compared with after control group treatment, △P< 0.05

As can be seen from Table 2, symptom score, colonoscopy performance scoring, colonic tissue pathological score, Mayo activity index are commented after 2 groups of treatments Reduction point before the treatment of relatively this group (P< 0.05), after treatment treatment group lower than control group (P< 0.05).

2.3 2 groups of pretherapy and post-treatment CRP, erythrocyte sedimentation rate (ESR)s are relatively shown in Table 3.

Table 32 groups of pretherapy and post-treatment CRP, erythrocyte sedimentation rate (ESR)s compare,

Seen from table 3, reduced before relatively this group treatment of CRP, erythrocyte sedimentation rate (ESR) after 2 groups of treatments (P< 0.05), it is treated after treatment Group lower than control group (P< 0.05).

Animal experiment study of the invention

Ulcerative colitis (ulcerative colitis, UC) is a kind of colonic mucosa inflammation that the cause of disease is unknown, many researchs It has proven convenient that excessive immune and dysimmunity, break proinflammatory factor and suppression inflammation because of quantum balancing, are the major reasons for causing UC.Bai Jie - 1 β of element can generate inflammatory mediator by autocrine or paracrine stimulation, provide for the activation of T lymphocyte and pass to signal, promotion The proliferation of B cell, differentiation enhance the tissue-damaging process that cellular immunity and humoral immunity mediate, the table of Cytokine protein It is positively correlated up to the degree of inflammation with UC, pretends the index to judge disease severity and curative effect.This research passes through Chinese medicine group Object is closed to the effect of UC rat colon tissue Interleukin -1β and the influence of protein expression, that inquires into traditional Chinese medicine composition for treating UC can Energy mechanism provides theoretical and experimental basis for clinical application.

1 material and method

1.1 experimental animal

Cleaning grade Wistar rat 60, male, weight (150 ± 30) g are provided by Hebei Medical University's experimental animal center.

1.2 drugs and reagent

Give oral traditional Chinese medicine composition: wrinkled giant hyssop 15g, eupatorium 12g, oriental wormwood 20g, talcum 30g, scorpio 9g, ground bettle 9g, root of Dahurain angelica 15g, Windproof 9g, red halloysite 12g, kaolinite 12g, kuh-seng 9g, Radix Isatidis 15g, Divine Comedy 9g, red yeast rice 9g, fructus amomi 9g, nutmeg 6g.Day 1 Agent, takes juice 400mL decocting 2 times.Give external medicine composition: wrinkled giant hyssop 15g, eupatorium 12g, oriental wormwood 20g, talcum 30g(punching), scorpio 9g, ground bettle 9g, root of Dahurain angelica 15g, radix saposhnikoviae 9g, red halloysite 12g, kaolinite 12g, kuh-seng 9g, Radix Isatidis 15g, Divine Comedy 9g, red yeast rice 9g, fructus amomi 9g, nutmeg 6g.1 dose of day juice 150mL is taken according to product prepared by the method for embodiment 6, night row instills operation.

Sulfasalazine (Fuda Pharmaceutical Co., Ltd., Shanghai, national drug standard H31020840), is dissolved in distilled water and is made into 0.9mg/ml solution.Interleukin -1β ELISA kit (lot number: SBJ-M0583, Nanjing Sen Beijia Biotechnology Co., Ltd).

1.3 animal packets and processing

Wistar rat is divided into normal group 10 and modeling group 50 using random digits table, modeling group uses trinitrobenzen Sulfonic acid/ethanol method establishes UC rat model, i.e., 100mg/kg trinitrobenzene sulfonic acid and 50% ethyl alcohol 0.25mL bowel lavage, totally 14 It.With rat excrement mucus purulence blood, 5 times/day of times of defecation > are normally to organize dead 2 during modeling Success criteria is raised.It makes Mould group dead 7, only 42 rats of residue 43 are successfully established model.Modeling success rat is divided into using random digits table Model group 8, positive drug group 8, high dose group 8, middle dose group 9, low dose group 9.Positive drug group gives willow nitrogen sulphur Amine pyridine 0.3g/(kgd) stomach-filling, high, medium and low dosage group gives oral traditional Chinese medicine composition 26g, 13g, 6.5g/(kg respectively D) stomach-filling, gives external medicine composition 26g, 13g, 6.5g/(kgd) bowel lavage, and model group gives equal amount of distilled water stomach-filling and filling Intestines, the normal normal raising of group, continuous 14 days.Observation index afterwards.

1.4 observation index

The expression of UC rat intestinal tissue Interleukin -1β assay and Interleukin -1β albumen in colonic tissue.

1.5 statistical method

Using 20.0 statistical software of SPSS carry out data analysis, measurement data with mean ± standard deviation () indicate, it adopts WithtIt examines, more comparison among groups use one-way analysis of variance, compare two-by-two between group using SNK method.

2 results

2. 1 each group rat colon tissue Interleukin -1β level is relatively shown in Table 4.

4 each group rat colon tissue Interleukin -1β level of table compares,

Compared with normal group, *P< 0.05；Compared with model group, △P< 0.05；Compared with positive drug group, ▲P< 0.05

As the result is shown, compared with normal group, model group Interleukin -1β level increase, have statistical significance (P< 0.05), Illustrate modeling success；Compared with model group, under positive drug group, high dose group, middle dose group, low dose group Interleukin -1β are horizontal Drop, have statistical significance (P< 0.05), illustrate that treatment is effective；Positive drug group Interleukin -1β level lower than middle dose group, Low dose group, have statistical significance (P< 0.05), illustrate positive drug group better than middle dose group, low dose group;High dose group Interleukin -1β level compared with positive drug group, it is not statistically significant (P> 0.05), illustrate high dose group and positive drug group curative effect Quite；Middle dose group Interleukin -1β level compared with low dose group, it is not statistically significant (P> 0.05), illustrate middle dose group with Low dose group therapeutic equivalence.

2. influence of 2 each groups to rat colon tissue Interleukin -1β protein expression is shown in Table 5.

Comparison of 5 each group of table to rat colon tissue Interleukin -1β protein expression,

The results show that compared with normal group, model group Interleukin -1β protein expression is increased, have statistical significance (P< 0.05), illustrate modeling success；Compared with model group, positive drug group, high dose group, middle dose group, low dose group Interleukin -1β Protein expression decline, have statistical significance (P< 0.05), illustrate that treatment is effective；Positive drug group Interleukin -1β albumen table Up to be lower than middle dose group, low dose group, have statistical significance (P< 0.05), illustrate positive drug group better than middle dose group, low dose Amount group;High dose group Interleukin -1β protein expression compared with positive drug group, it is not statistically significant (P> 0.05), illustrate high agent Amount group and positive drug group therapeutic equivalence；Middle dose group Interleukin -1β protein expression compared with low dose group, it is not statistically significant (P > 0.05), illustrate middle dose group and low dose group therapeutic equivalence.

Typical case

1. patient is permitted certain, male, and 29 years old.The first visit on the 22nd of August in 2016.Main suit: interruption mucus pus and blood stool 2 years, then send out 3 days.Now lead Disease: mucus pus and blood stool, 6 times/day, abdominal pain, left lower quadrant is obvious, alleviates after an action of the bowels, out of strength, the dark red thick,yellow and greasy fur of tongue, wiry and rolling pulse.Zeng Yu Two years ago is diagnosed as ulcerative colitis in The People's Hospital of Peking University, irregular to take Sha Erfu (Mesalazine enteric-coated tablet) 2g, 2 times a day.Yesterday is in our hospital's row electronic colonoscope: ulcerative colitis (chronic relapsing, left hemicolon, active stage, moderate). Doctor trained in Western medicine diagnosis: ulcerative colitis (chronic relapsing, left hemicolon, active stage, moderate).Tcm diagnosis: diarrhea disease, dialectical: Accumulate in turbid poison.It is medicinal: to give oral traditional Chinese medicine composition: wrinkled giant hyssop 15g, eupatorium 12g, oriental wormwood 20g, talcum 30g, scorpio 9g, ground bettle 9g, root of Dahurain angelica 15g, radix saposhnikoviae 9g, red halloysite 12g, kaolinite 12g, kuh-seng 9g, Radix Isatidis 15g, Divine Comedy 9g, red yeast rice 9g, fructus amomi 9g, Nutmeg 6g.Day 1 dose, take juice 400mL decocting 2 times.Give external medicine composition: wrinkled giant hyssop 15g, eupatorium 12g, oriental wormwood 20g, talcum 30g(punching), scorpio 9g, ground bettle 9g, root of Dahurain angelica 15g, radix saposhnikoviae 9g, red halloysite 12g, kaolinite 12g, kuh-seng 9g, Radix Isatidis 15g, Divine Comedy 9g, red yeast rice 9g, fructus amomi 9g, nutmeg 6g.1 dose of day juice 150mL is taken according to product prepared by the method for embodiment 6, daily Chinese medicine Enem-d.30 doses of clothes top advises its few slag to exempt from milk diet.Monthly outpatient service is taken medicine more than 2 months altogether, and abdominal pain is obvious good earlier above Turn, defecates 3 times/day, no mucus purulence blood.It advises above its following the service 1 month, one dose per day, uncomfortable follow-up.

2. patient just certain, female, 66 years old.First visit on the 1st in 2 months in 2017.Main suit: interruption mucus pus and blood stool 4 years, then send out 2 days.It is existing Primary symptom: mucus pus and blood stool, 4 times/day, abdominal pain, lower abdomen is obvious, alleviates after an action of the bowels, tenesmus, the dark red thick,yellow and greasy fur of tongue, slippery.Once It was diagnosed as proctitis ulcerosa in No.2 Hospital, Hebei Medical Univ. before 10 years, interruption uses Sha Erfu (Mesalazine enteric Piece) 2g, 2 times a day and Sha Erfu (Mesalazine bolt) 1g, one time a day.In our hospital's row electronic colonoscope before 2 days: exedens knot Enteritis (chronic relapsing, rectum, active stage, slight).Doctor trained in Western medicine diagnosis: ulcerative colitis (chronic relapsing, rectum, activity It is phase, slight).Tcm diagnosis: diarrhea disease, it is dialectical: to accumulate in turbid poison.It is medicinal: give oral traditional Chinese medicine composition: wrinkled giant hyssop 15g, eupatorium 12g, Oriental wormwood 20g, talcum 30g, scorpio 9g, ground bettle 9g, root of Dahurain angelica 15g, radix saposhnikoviae 9g, red halloysite 12g, kaolinite 12g, kuh-seng 9g, plate Blue root 15g, Divine Comedy 9g, red yeast rice 9g, fructus amomi 9g, nutmeg 6g.Day 1 dose, take juice 400mL decocting 2 times.Give external application Chinese medicine combination Object: wrinkled giant hyssop 15g, eupatorium 12g, oriental wormwood 20g, talcum 30g(punching), scorpio 9g, ground bettle 9g, root of Dahurain angelica 15g, radix saposhnikoviae 9g, red halloysite 12g, kaolinite 12g, kuh-seng 9g, Radix Isatidis 15g, Divine Comedy 9g, red yeast rice 9g, fructus amomi 9g, nutmeg 6g.1 dose of day, according to embodiment The product of 6 method preparation takes juice 150mL, daily Chinese medicine Enem-d.14 doses of clothes top advises its few slag to exempt from milk diet.14 doses Further consultation afterwards, patient's mucus pus and blood stool, 1-2 times/day, abdominal pain mitigates earlier above, and lower abdomen is obvious, alleviates after an action of the bowels, still there is tenesmus, tongue Dark red yellow and greasy fur, slippery.30 doses and daily bowel lavage above following the service.Monthly outpatient service, after medication more than January, abdominal pain improves earlier above, stool 1-2 times/day, no mucus purulence blood.Uncomfortable follow-up.

3. patient Liang, female, 34 years old.First visit on May 1 in 2018.Main suit: interruption abdominal pain was aggravated with mucus pus and blood stool 1 year 7 days.Existing primary symptom: mucus pus and blood stool, 10 times/day, abdominal pain, lower abdomen is obvious, alleviates after an action of the bowels, tenesmus, out of strength, canker sore, The dark red yellow and greasy fur of tongue, slippery.Once it was diagnosed as ulcerative colitis in the people's hospital of Heibei before 3 years, rule takes Sha Erfu (Mesalazine enteric-coated tablet) 2g, 2 times a day, Yu Shangzhou out on tours, off-drug aggravates after 2 weeks.In the people's hospital of Heibei's row electricity Sub- Sigmoidoscope: ulcerative colitis (chronic relapsing, extensive colon, active stage, severe).Doctor trained in Western medicine diagnosis: ulcerative colitis (chronic relapsing, extensive colon, active stage, severe).Tcm diagnosis: diarrhea disease, it is dialectical: to accumulate in turbid poison.It is medicinal: to give in for oral administration Drug composition: wrinkled giant hyssop 15g, eupatorium 12g, oriental wormwood 20g, talcum 30g, scorpio 9g, ground bettle 9g, root of Dahurain angelica 15g, radix saposhnikoviae 9g, red stone Rouge 12g, kaolinite 12g, kuh-seng 9g, Radix Isatidis 15g, Divine Comedy 9g, red yeast rice 9g, fructus amomi 9g, nutmeg 6g.1 dose, decocting 2 times of day Take juice 400mL.Give external medicine composition: wrinkled giant hyssop 15g, eupatorium 12g, oriental wormwood 20g, talcum 30g(punching), scorpio 9g, ground bettle 9g, root of Dahurain angelica 15g, radix saposhnikoviae 9g, red halloysite 12g, kaolinite 12g, kuh-seng 9g, Radix Isatidis 15g, Divine Comedy 9g, red yeast rice 9g, fructus amomi 9g, Nutmeg 6g.1 dose of day, juice 150mL, daily Chinese medicine Enem-d were taken according to product prepared by the method for embodiment 6.Clothes top 7 Agent advises its few slag to exempt from milk diet.Further consultation after 7 doses, patient's mucus pus and blood stool improve earlier above, 6 times/day, abdominal pain, it is tenesmus earlier above Mitigate, the dark red yellow and greasy fur of tongue, slippery.Further consultation after 14 doses, 14 doses, 4 times/day of patient's mucus pus and blood stool above following the service, occasionally have abdominal pain, It is tenesmus, cold object cannot be eaten, abdominal pain is repeatedly after eating cold object.Patient is advised to continue 30 doses of clothes top and daily Chinese medicine rectum drop Enter, after medication more than January, abdominal pain improves earlier above, it defecates 1-2 times/day, no mucus purulence blood.

Claims

1. a kind of Chinese medicine composition given orally or externally for treating ulcerative colitis, which is characterized in that including oral traditional Chinese medicine composition And external medicine composition；

2. a kind of Chinese medicine composition given orally or externally for treating ulcerative colitis according to claim 1, which is characterized in that Oral traditional Chinese medicine composition includes the Chinese medicine composition of following parts by weight: 15 parts of wrinkled giant hyssop, 12 parts of eupatorium, 20 parts of oriental wormwood, 30 parts of talcum, 9 parts of scorpio, 9 parts of ground bettle, 15 parts of the root of Dahurain angelica, radix saposhnikoviae 9 parts, 12 parts of red halloysite, 12 parts of kaolinite, 9 parts of kuh-seng, 15 parts of Radix Isatidis, 9 parts of Divine Comedy, 9 parts of red yeast rice, 9 parts of fructus amomi, 6 parts of nutmeg；

3. the preparation method of Chinese medicine composition of any of claims 1 or 2, which is characterized in that the preparation of oral traditional Chinese medicine composition Method the following steps are included:

(4) into the medical fluid of step (3) be added step (1) in talcum, talcum is placed in grey cotton fabric cloth bag carry out it is pan-fried It boils, is decocted 0.5 hour after boiling；

(7) after the mixed filtrate that step (6) obtains being heated to 70 DEG C, clear solution is obtained by filtration, is filled in container, 121 DEG C, 20 minutes normal-pressure sterilizations；

4. preparation method according to claim 3, which is characterized in that the step in the preparation method of oral traditional Chinese medicine composition (4) grey cotton fabric cloth bag is hospital gauze cloth bag.