CN109943478A - A kind of genetic chip automatic station-keeping system - Google Patents
A kind of genetic chip automatic station-keeping system Download PDFInfo
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- CN109943478A CN109943478A CN201910304913.5A CN201910304913A CN109943478A CN 109943478 A CN109943478 A CN 109943478A CN 201910304913 A CN201910304913 A CN 201910304913A CN 109943478 A CN109943478 A CN 109943478A
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- fixing seat
- chip
- dimensional motion
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- 230000002068 genetic effect Effects 0.000 title claims abstract description 21
- 230000007246 mechanism Effects 0.000 claims abstract description 40
- 230000035807 sensation Effects 0.000 claims abstract description 11
- 238000012163 sequencing technique Methods 0.000 claims description 16
- 239000007787 solid Substances 0.000 claims 1
- 238000011160 research Methods 0.000 description 3
- 230000009471 action Effects 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 230000014509 gene expression Effects 0.000 description 1
- 238000003205 genotyping method Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000002493 microarray Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
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- 108090000623 proteins and genes Proteins 0.000 description 1
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Abstract
The invention discloses a kind of genetic chip automatic station-keeping systems, which is characterized in that including control system, two-dimensional motion mechanism and micro-adjusting mechanism；Two-dimensional motion mechanism is controlled by control system substantially to adjust the position of genetic chip fixing seat, then controls micro-adjusting mechanism and overlaps to camera lens is sequenced being finely adjusted the light sensation anchor point for taking laser beam and genetic chip, achievees the purpose that quickly to position；The present invention has accurate positioning, quick, the feature that performance is stable, automation is high.
Description
Technical field
The present invention relates to a kind of genetic chip automatic station-keeping systems.
Background
The development of detection device based on micro-array chip has greatly changed the looks of biotechnology industry.These
Equipment to detect a variety of biological samples simultaneously, detects rare source of people transcript.In the case where exciting light action, chip
On fluorescence probe launch Stokes shift light, and the transmitting light is then acquired by photomultiplier tube.So obtain micro- battle array
The information of column chip can service for a variety of researchs, such as gene expression research, variation research, Genotyping, and mononucleotide is more
State property, protein-interacting, there are also the diagnosing and treatings of disease.When carrying out the information collection of genetic chip, need to grasp
Make personnel genetic chip is positioned and focused manually, whole process is very complicated, therefore we devise a kind of gene core
Piece automatic station-keeping system solves the above problems.
Summary of the invention
The purpose of the present invention is to solve the above the deficiencies in the prior art, provide a kind of genetic chip automatic positioning system
System.
The technical scheme adopted by the invention is that a kind of such, genetic chip automatic station-keeping system, including control system
And positioning mechanism；
The positioning mechanism includes the two-dimensional motion mechanism and control for controlling genetic chip fixing seat and moving on the table
Sequencing camera lens carries out the micro-adjusting mechanism that subtle adjustment is carried out on lens mount；It is equipped on the two-dimensional motion mechanism overlay area
The rectangular photosensitive element embarked on journey in column, the photosensitive element are arranged position according to it and carry out label, are stored in control system；The core
Light sensation anchor point is provided in piece fixing seat；Laser emitter is provided on the sequencing camera lens；The two-dimensional motion mechanism and
Micro-adjusting mechanism is connected with the CPU of control system；
The control system includes the coordinate system generation unit being connected with CPU, path planning unit and motor control unit；
When the described automatic station-keeping system operation the following steps are included:
A. start laser emitter, sequencing camera lens is moved into two-dimensional motion mechanism overlay area；
B. photosensitive element receives the laser signal of laser emitter and is passed to CPU；
C.CPU receives the laser signal of rectangular photosensitive element transmitting and incoming coordinate system generation unit；
D. coordinate system generation unit generates coordinate system according to the number of rectangular photosensitive element, and incoming laser signal is being sat
Mark, which is fastened, to be labeled, as sequencing lens location, since chip fixing seat is fixed in two-dimensional motion mechanism, so position is
Determining, this information is also labeled on coordinate system；
E. path planning unit obtains sequencing lens location and chip fixing seat position and generates shortest path, the road Bing Jiangci
Diameter travel information is converted into electronic signal and is passed to motor control unit；
F. chip fixing seat is adjusted to laser and is sent out according to incoming motor signal control motor operating by motor control unit
On the photosensitive element of emitter irradiation；
G.CPU controls micro-adjusting mechanism and carries out camera lens fine tuning, and planning path makes and Laser emission its laser is fixed in chip
It carries out scanning without dead angle on seat coinciding until with the light sensation anchor point in chip fixing seat, be returned receiving light sensation anchor point
Signal after complete automatic positioning.
Preferably, the two-dimensional motion mechanism includes the linear motor one and and straight line of a setting on the table
The parallel horizontal concrete chute of motor；Linear motor two, the straight-line electric are provided between the linear motor one and horizontal concrete chute
Machine two can be slided by the driving of linear motor one along one length direction of linear motor；Chip is provided on the linear motor two to fix
, it is provided with chip card slot in the chip fixing seat and can be slided by two drives edge linear motor of linear motor, two length direction
It is dynamic.
Preferably, the micro-adjusting mechanism includes that the transverse and longitudinal being arranged on camera lens adjusts screw and driving adjusting screw turn
Dynamic small machine.
Preferably, laser positioning point number is identical with the laser beam number of laser transmitter projects, is all 3.
The utility model has the advantages that
The present invention controls two dimensional motion by control system substantially to be adjusted to the position of genetic chip fixing seat first
It is whole, the light sensation anchor point phase mutual respect for taking laser beam and genetic chip is finely adjusted to sequencing camera lens in control micro-adjusting mechanism
It closes, achievees the purpose that quickly to position；The present invention has accurate positioning, quick, the feature that performance is stable, automation is high.
Detailed description of the invention
Fig. 1 is schematic structural view of the invention；
Fig. 2 is present invention automatic positioning flow chart of steps.
Specific embodiment
In order to deepen the understanding of the present invention, below in conjunction with embodiment and attached drawing, the invention will be further described, should
The examples are only for explaining the invention, is not intended to limit the scope of the present invention..
As shown in Figs. 1-2, a kind of genetic chip automatic station-keeping system, including control system and positioning mechanism；
The positioning mechanism includes the two-dimensional motion mechanism and control for controlling genetic chip fixing seat and moving on the table
Sequencing camera lens carries out the micro-adjusting mechanism that subtle adjustment is carried out on lens mount；It is equipped on the two-dimensional motion mechanism overlay area
The rectangular photosensitive element embarked on journey in column, the photosensitive element are arranged position according to it and carry out label, are stored in control system；The core
Light sensation anchor point is provided in piece fixing seat；Laser emitter is provided on the sequencing camera lens；The two-dimensional motion mechanism and
Micro-adjusting mechanism is connected with the CPU of control system；
The control system includes the coordinate system generation unit being connected with CPU, path planning unit and motor control unit；
When the described automatic station-keeping system operation the following steps are included:
A. start laser emitter, sequencing camera lens is moved into two-dimensional motion mechanism overlay area；
B. photosensitive element receives the laser signal of laser emitter and is passed to CPU；
C.CPU receives the laser signal of rectangular photosensitive element transmitting and incoming coordinate system generation unit；
D. coordinate system generation unit generates coordinate system according to the number of rectangular photosensitive element, and incoming laser signal is being sat
Mark, which is fastened, to be labeled, as sequencing lens location, since chip fixing seat is fixed in two-dimensional motion mechanism, so position is
Determining, this information is also labeled on coordinate system；
E. path planning unit obtains sequencing lens location and chip fixing seat position and generates shortest path, the road Bing Jiangci
Diameter travel information is converted into electronic signal and is passed to motor control unit；
F. chip fixing seat is adjusted to laser and is sent out according to incoming motor signal control motor operating by motor control unit
On the photosensitive element of emitter irradiation；
G.CPU controls micro-adjusting mechanism and carries out camera lens fine tuning, and planning path makes and Laser emission its laser is fixed in chip
It carries out scanning without dead angle on seat coinciding until with the light sensation anchor point in chip fixing seat, be returned receiving light sensation anchor point
Signal after complete automatic positioning.
In the present embodiment, the two-dimensional motion mechanism includes one He of linear motor of a setting on the table
The horizontal concrete chute parallel with linear motor；Linear motor two is provided between the linear motor one and horizontal concrete chute, it is described
Linear motor two can be slided by the driving of linear motor one along one length direction of linear motor；Core is provided on the linear motor two
Piece fixing seat, is provided with chip card slot in the chip fixing seat and can be by two drives edge linear motor of linear motor, two length side
To sliding, the micro-adjusting mechanism includes the small electricity that the transverse and longitudinal being arranged on camera lens adjusts screw and driving adjusting screw rotation
Machine, the laser positioning point number is identical with the laser beam number of laser transmitter projects, is all 3.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention
Within mind and principle, any modification, equivalent replacement, improvement and so on be should all be included in the protection scope of the present invention.
Claims (5)
1. a kind of genetic chip automatic station-keeping system, which is characterized in that including control system and positioning mechanism；
The positioning mechanism includes controlling the two-dimensional motion mechanism and control sequencing that genetic chip fixing seat moves on the table
Camera lens carries out the micro-adjusting mechanism that subtle adjustment is carried out on lens mount；It is equipped with and embarks on journey on the two-dimensional motion mechanism overlay area
Rectangular photosensitive element in column, the photosensitive element are arranged position according to it and carry out label, are stored in control system；The chip is solid
Light sensation anchor point is provided in reservation；Laser emitter is provided on the sequencing camera lens；The two-dimensional motion mechanism and fine tuning
Mechanism is connected with the CPU of control system；
The control system includes the coordinate system generation unit being connected with CPU, path planning unit and motor control unit；
When the described automatic station-keeping system operation the following steps are included:
A. start laser emitter, sequencing camera lens is moved into two-dimensional motion mechanism overlay area；
B. photosensitive element receives the laser signal of laser emitter and is passed to CPU；
C.CPU receives the laser signal of rectangular photosensitive element transmitting and incoming coordinate system generation unit；
D. coordinate system generation unit generates coordinate system according to the number of rectangular photosensitive element, by incoming laser signal in coordinate system
On be labeled, as sequencing lens location, since chip fixing seat is fixed in two-dimensional motion mechanism, so position is determining
, this information is also labeled on coordinate system；
E. path planning unit obtains sequencing lens location and chip fixing seat position and generates shortest path, and by this path row
Electronic signal, which is converted into, into information is passed to motor control unit；
F. motor control unit adjusts chip fixing seat to laser emitter according to incoming motor signal control motor operating
On the photosensitive element of irradiation；
G.CPU controls micro-adjusting mechanism and carries out camera lens fine tuning, and planning path makes and Laser emission its laser is in chip fixing seat
Scanned without dead angle and coincide until with the light sensation anchor point in chip fixing seat, in the letter for receiving the return of light sensation anchor point
Automatic positioning is completed after number.
2. a kind of genetic chip automatic station-keeping system as described in claim 1, which is characterized in that the two dimensional motion machine
Structure includes the linear motor one and the horizontal concrete chute parallel with linear motor of a setting on the table；The linear motor
Linear motor two is provided between one and horizontal concrete chute, the linear motor two can be along linear motor one by the driving of linear motor one
Length direction sliding；It is provided with chip fixing seat on the linear motor two, is provided with chip card slot in the chip fixing seat
And it can be slided by two drives edge linear motor of linear motor, two length direction.
3. a kind of genetic chip automatic station-keeping system as described in claim 1, which is characterized in that the micro-adjusting mechanism packet
Include the small machine that the transverse and longitudinal being arranged on camera lens adjusts screw and driving adjusting screw rotation.
4. a kind of genetic chip automatic station-keeping system as described in claim 1, which is characterized in that the laser positioning points
Mesh is identical with the laser beam number of laser transmitter projects.
5. a kind of genetic chip automatic station-keeping system as claimed in claim 4, which is characterized in that the laser positioning point number
Laser beam number with laser transmitter projects is 3.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201910304913.5A CN109943478A (en) | 2019-04-16 | 2019-04-16 | A kind of genetic chip automatic station-keeping system |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910304913.5A CN109943478A (en) | 2019-04-16 | 2019-04-16 | A kind of genetic chip automatic station-keeping system |
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| CN109943478A true CN109943478A (en) | 2019-06-28 |
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH1144693A (en) * | 1997-07-25 | 1999-02-16 | Agency Of Ind Science & Technol | Method and apparatus for measurement of position of probe chip in near-field optical microscope and control device therefor |
| JP2009103641A (en) * | 2007-10-25 | 2009-05-14 | Konica Minolta Medical & Graphic Inc | Inspection apparatus |
| CN101520415A (en) * | 2008-02-29 | 2009-09-02 | 中国科学院大连化学物理研究所 | Micro-fluidic laser-induced fluorescence detector with functions of automatic positioning and focusing |
| CN106520535A (en) * | 2016-10-12 | 2017-03-22 | 山东大学 | Label-free cell detection device and method based on light sheet illumination |
| CN206399834U (en) * | 2017-01-14 | 2017-08-11 | 辽宁工业大学 | A fast positioning device for plug-in microfluidic chip |
| CN107144526A (en) * | 2017-03-16 | 2017-09-08 | 南通大学 | A kind of micro-displacement control device observed suitable for micro-fluidic chip and application method |
| CN109218592A (en) * | 2018-11-19 | 2019-01-15 | 深圳闳泰科技有限公司 | A kind of camera lens and detector horizontal-shift adjustable composite lens mount |
-
2019
- 2019-04-16 CN CN201910304913.5A patent/CN109943478A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH1144693A (en) * | 1997-07-25 | 1999-02-16 | Agency Of Ind Science & Technol | Method and apparatus for measurement of position of probe chip in near-field optical microscope and control device therefor |
| JP2009103641A (en) * | 2007-10-25 | 2009-05-14 | Konica Minolta Medical & Graphic Inc | Inspection apparatus |
| CN101520415A (en) * | 2008-02-29 | 2009-09-02 | 中国科学院大连化学物理研究所 | Micro-fluidic laser-induced fluorescence detector with functions of automatic positioning and focusing |
| CN106520535A (en) * | 2016-10-12 | 2017-03-22 | 山东大学 | Label-free cell detection device and method based on light sheet illumination |
| CN206399834U (en) * | 2017-01-14 | 2017-08-11 | 辽宁工业大学 | A fast positioning device for plug-in microfluidic chip |
| CN107144526A (en) * | 2017-03-16 | 2017-09-08 | 南通大学 | A kind of micro-displacement control device observed suitable for micro-fluidic chip and application method |
| CN109218592A (en) * | 2018-11-19 | 2019-01-15 | 深圳闳泰科技有限公司 | A kind of camera lens and detector horizontal-shift adjustable composite lens mount |
Non-Patent Citations (2)
| Title |
|---|
| 付云博 等: "基因测序仪运动平台的高精度定位控制", 《光学 精密工程》 * |
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Application publication date: 20190628 |
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