CN109908298A - A kind of bone fracture bruise external preparation and preparation method thereof - Google Patents
A kind of bone fracture bruise external preparation and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of bone fracture bruise external preparations, the bulk pharmaceutical chemicals of the external preparation are according to the mass fraction, it include: 11~15 parts of radix achyranthis bidentatae, 11~15 parts of rheum officinale, 11~15 parts of radix angelicae sinensis, 11~15 parts of curcuma zedoary, 11~15 parts of trigone, 0.8~2 part of vinegar myrrh, 0.8~2 part of vinegar frankincense, 11~15 parts of Cortex Phellodendri, 11~15 parts of radix fici simplicissimae, 11~15 parts of hypericum japonicum, 11~15 parts of Thickleaf Croton Root, 11~15 parts of radix paeoniae rubra, 11~15 parts of the rhizome of davallia, 11~15 parts of teasel root, 11~15 parts of the root of Dahurain angelica, 11~15 parts of caulis trachelospermi, 11~15 parts of radix saposhnikoviae, 11~15 parts of Chinese sumac, 11~15 parts of the root of three-nerved spicebush, 11~15 parts of herba lysimachiae, 11~15 parts of schizonepeta, 11~15 parts of Herba Lycopi, 2~4 parts of safflower, solely It is 0.8~2 part, 0.8~2 part of Rhizoma Et Radix Notopterygii living.All medicines share plays the function of sensible promoting blood circulation, removing blood stasis and acesodyne, detumescence and promoting granulation, strengthening the muscles and bones altogether, and to bruises and sprains, injured bones and muscles, the diseases such as product swelling due to stasis are significant in efficacy.
Description
Technical field
The present invention relates to a kind of bone fracture bruise external preparations and preparation method thereof.
Background technique
Traumatic injury is mostly caused by external force, is led to muscle flesh bone damage, then channels and collaterals is caused to hinder, qi and blood stagnation,
Hemostasis is generated, symptom is local swelling, pain, ecchymosis, limb activity are limited etc..Swelling caused by bruises and sprains, pain belong to
Common clinical disease, frequently-occurring disease, every year since above-mentioned illness is hospitalized or medical patient is numerous, morbidity is anxious, is accompanied by pain, suffers from
Person is very painful, and it is also higher to influence work, study, medical expense.
Activating microcirculation and removing stasis medicinal, swelling and pain relieving should be its primary treatment principle, and doctor trained in Western medicine often selects non-steroidal anti-inflammatory drugs, such as helps him
Woods, not Bick, happy pine, day Xin Lide, Celebrex, ten thousand Lip rivers etc., easing pain and diminishing inflammation, but these drugs are usually palliative, only delay
Symptom is solved, causes patient's course of disease long, rehabilitation is slow, and Long-term taking medicine has biggish side effect.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of good effect, the bone fracture traumatic injury treating medicine drugs of Small side effects.
In order to solve the above technical problems, the invention discloses a kind of bone fracture bruise external preparation, the original of the external preparation
Expect medicine according to the mass fraction, comprising: 11~15 parts of radix achyranthis bidentatae, 11~15 parts of rheum officinale, 11~15 parts of radix angelicae sinensis, 11~15 parts of curcuma zedoary,
11~15 parts of trigone, 0.8~2 part of vinegar myrrh, 0.8~2 part of vinegar frankincense, 11~15 parts of Cortex Phellodendri, 11~15 parts of radix fici simplicissimae,
11~15 parts of hypericum japonicum, 11~15 parts of Thickleaf Croton Root, 11~15 parts of radix paeoniae rubra, 11~15 parts of the rhizome of davallia, 11~15 parts of teasel root, the root of Dahurain angelica 11
~15 parts, 11~15 parts of caulis trachelospermi, windproof 11~15 parts, 11~15 parts of Chinese sumac, 11~15 parts of the root of three-nerved spicebush, herba lysimachiae 11~15
Part, 5~8 parts of schizonepeta, 11~15 parts of Herba Lycopi, 2~4 parts of safflower, 0.8~2 part of Radix Angelicae Pubescentis, 0.8~2 part of Rhizoma Et Radix Notopterygii.
It is preferred that the bulk pharmaceutical chemicals of the external preparation are according to the mass fraction, comprising: 13 parts of radix achyranthis bidentatae, 13 parts of rheum officinale, radix angelicae sinensis 13
Part, 13 parts of curcuma zedoary, 13 parts of trigone, 1.3 parts of vinegar myrrh, 1.3 parts of vinegar frankincense, 13 parts of Cortex Phellodendri, 13 parts of radix fici simplicissimae, hypericum japonicum
13 parts, 13 parts of Thickleaf Croton Root, 13 parts of radix paeoniae rubra, 13 parts of the rhizome of davallia, 13 parts of teasel root, 13 parts of the root of Dahurain angelica, 13 parts of caulis trachelospermi, windproof 13 parts, salt
Skin wood 13 parts, 13 parts of the root of three-nerved spicebush, 13 parts of herba lysimachiae, 6.5 parts of schizonepeta, 13 parts of Herba Lycopi, 2.5 parts of safflower, 1.3 parts of Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii 1.3
Part.
The 25 taste Chinese prescriptions such as the preferred radix achyranthis bidentatae of external preparation disclosed in this invention, rheum officinale, radix angelicae sinensis, radix achyranthis bidentatae are logical by the stasis of blood
Through, nourishing liver and kidney, strengthening the bones and muscles；Rheum officinale removing dampness through diuresis and removing jaundice, removing toxicity for eliminating carbuncles；Radix angelicae sinensis promoting blood circulation, by the stagnant swelling and pain of stagnation resolvation blood；Curcuma zedoary is broken
Gas promoting circulation of blood, clearing stagnation and killing pain；Trigone hemostasis, breaking blood and promoting the circulation of qi；Myrrh promoting blood circulation and stopping pain, dissipates blood and dissolving stasis at detumescence and promoting granulation；Olibanum anti-inflammatory is anti-
Rotten, detumescence and promoting granulation；Cortex Phellodendri heat-clearing and damp-drying drug, purging fire for removing toxin, Hepatoprotective cholagogue；Radix fici simplicissimae promoting the circulation of qi dampness removing, relaxing tendons and activating collaterals；Hypericum japonicum is clear
Hot dampness removing；Removing toxic substances；Eliminating stasis to subdue swelling；Thickleaf Croton Root promoting qi circulation and relieving pain, wind-dispelling detumescence；The radix paeoniae rubra row stasis of blood, analgesic, cool blood, detumescence；The rhizome of davallia is mended
The strong bone of kidney, continues and hinders pain relieving；Teasel root nourishing liver and kidney, strengthening the bones and muscles；The dehumidifying of root of Dahurain angelica relieve heat, sensible analgesic, detumescence and apocenosis；Caulis trachelospermi wind-dispelling is logical
Network, cool blood detumescence；Radix saposhnikoviae expels pathogenic wind from the body surface, antibacterial, antipruritic；Chinese sumac is clearing heat and detoxicating, dissipating stasis and stanching bleeding；The pleasant analgesic of the root of three-nerved spicebush, warm kidney
Cold dispelling；Herba lysimachiae clearing heat and promoting diuresis, the removing toxic substances of row's stone, removing blood stasis and acesodyne；Schizonepeta wind-dispelling, inducing diaphoresis, promoting eruption, hemostasis；Herba Lycopi blood circulation, benefit
Water detumescence；Safflower blood circulation, removing blood stasis and acesodyne；Radix Angelicae Pubescentis dispelling wind and eliminating dampness, numbness relieving and pain relieving；Rhizoma Et Radix Notopterygii cold dispelling, wind-dispelling dehumidify, analgesic.Side
Middle selection radix achyranthis bidentatae, radix angelicae sinensis, radix paeoniae rubra, the rhizome of davallia, teasel root and Herba Lycopi promoting blood circulation, swelling and pain relieving, strengthening the muscles and bones；Share curcuma zedoary,
Promoting blood circulation, swelling and pain relieving effect are reinforced in trigone, radix fici simplicissimae, Thickleaf Croton Root and root of three-nerved spicebush promoting the circulation of qi blood-breaking, relaxing tendons and activating collaterals；It is equipped with big
Huang, Cortex Phellodendri, hypericum japonicum, herba lysimachiae and Chinese sumac clearing heat and promoting diuresis, removing toxic substances, eliminating stasis to subdue swelling；Be equipped with again the root of Dahurain angelica, caulis trachelospermi, radix saposhnikoviae, solely
Living and notopterygium wind dispelling inducing diaphoresis, numbness relieving and pain relieving；The benefits of using myrrh, olibanum and safflower again, promoting blood circulation and stopping pain, detumescence and promoting granulation helped with assistant.It is all
Medicine shares, and plays the function of sensible promoting blood circulation, removing blood stasis and acesodyne, detumescence and promoting granulation, strengthening the muscles and bones altogether, and to bruises and sprains, injured bones and muscles, the product stasis of blood is swollen
The diseases such as pain are significant in efficacy, and are external preparation, and liver first-pass effect does not occur, is not influenced by factors such as gastric emptying and liver functions,
Be not likely to produce incompatibility, avoid the adverse reaction that Long-term Oral drug generates body, at the same have effect it is straightforward rapidly,
The efficacy of a drug is lasting, using advantages such as simplicity.
Bone fracture bruise external preparation disclosed in this invention can be ointment or plastics.
Vaseline can be added in ointment, can be prepared with following steps: 1) weighing bulk pharmaceutical chemicals, crush, cross 80 meshes；
2) vaseline is added, stirs evenly to obtain the final product.Ointment preparation process is simple, easily operated.
Plastics can also be prepared as, contain skin penetration enhancer and filmogen, the transdermal suction in the plastics
Receiving promotor is menthol or borneol, and the filmogen is acrylic resin III or Bletilla glucomannan.It can contain according to the mass fraction
30~40 parts of menthol, III 50~60 parts of acrylic resin preferably comprise 20~30 parts of borneol, 35~45 parts of Bletilla glucomannan.Borneol
The property altered, guidance drug transdermal are walked up to passing through, bletilla striata astringing to arrest bleeding, detumescence and promoting granulation helps and helps other components, can play better medicine
Effect.
The Bletilla glucomannan is made by the steps: 1) bletilla striata crushes, and 5 times of amount water are added, and ultrasound is impregnated 6 hours；2) mistake
Filter, takes filtrate, adds ethyl alcohol to ethanol content 70%, places 8 hours；3) it filters, 1 times of 95% alcohol solution dipping of amount of sediment
2 hours, filtering drained, 65 DEG C obtained by drying.
The plastics can be prepared with following steps: 1) weighing bulk pharmaceutical chemicals, crush, with 5 times of 80~90% ethyl alcohol of amount
Dipping 48 hours or more, maceration extract was collected in filtration；2) maceration extract is concentrated under reduced pressure into 600 parts by weight, and Transdermal absorption is added and promotes
Agent, dissolution, for use；3) it after separately filmogen being taken to be dissolved with ethanol water, is added in step 2) concentrate, it is stirring while adding,
Ethanol water is added again to 1000 parts by weight to obtain the final product.
Although plastics, compared with ointment, more bulk pharmaceutical chemicals extract concentration, plastics entirety preparation process
Also and uncomplicated, without material of mounting, without special mechanical equipment, manufacturing cost is not high；It is applied to affected part, solvent volatilization simultaneously
After form film, play the role of protect the surface of a wound.Said preparation is easy to carry, easy to use, and not by surface of a wound shape, size and portion
The limitation of position can also carry out controlling outside internal injury according to acupoint therapy.It is uneven to overcome ointment granularity, hair may be blocked by having
The disadvantages of hole, skin are also easy to produce allergy, are not suitable for acute and volume diffusate affected part, clothes easy to pollute, inconvenient to use.
Specific embodiment
Above content of the invention is described in further detail again below by way of specific embodiment.But this should not be managed
Solution is limited only to embodiment below for the range of the above-mentioned theme of the present invention.The case where not departing from above-mentioned technical idea of the invention
Under, the various replacements or change made according to ordinary skill knowledge and customary means, should all include in model of the invention
In enclosing.
Embodiment 1
Formula:
Radix achyranthis bidentatae 11g, rheum officinale 11g, Radix Angelicae Sinensis (tail) 11g, curcuma zedoary 11g, trigone 15g, myrrh (vinegar system) 0.8g, olibanum (vinegar system)
0.8g, Cortex Phellodendri 11g, radix fici simplicissimae 15g, hypericum japonicum 13g, chicken bone 15g, radix paeoniae rubra 11g, rhizome of davallia 11g, teasel root 11g, root of Dahurain angelica 25g,
Caulis trachelospermi 11g, radix saposhnikoviae 11g, Chinese sumac 15g, root of three-nerved spicebush 11g, herba lysimachiae 11g, schizonepeta 8g, Herba Lycopi 15g, safflower 4g, Radix Angelicae Pubescentis 0.8g,
Rhizoma Et Radix Notopterygii 2g
Preparation method:
1) bulk pharmaceutical chemicals are weighed, are crushed, 80 meshes are crossed；
2) vaseline is added to 1000g, stirs evenly to obtain the final product.
Embodiment 2
Formula:
Radix achyranthis bidentatae 13g, rheum officinale 13g, Radix Angelicae Sinensis (tail) 13g, curcuma zedoary 13g, trigone 13g, myrrh (vinegar system) 1.3g, olibanum (vinegar system)
1.3g, Cortex Phellodendri 13g, radix fici simplicissimae 13g, hypericum japonicum 13g, Thickleaf Croton Root 13g, radix paeoniae rubra 13g, rhizome of davallia 13g, teasel root 13g, the root of Dahurain angelica
13g, caulis trachelospermi 13g, radix saposhnikoviae 13g, Chinese sumac 13g, root of three-nerved spicebush 13g, herba lysimachiae 13g, schizonepeta 6.5g, Herba Lycopi 13g, safflower 2.5g,
Radix Angelicae Pubescentis 1.3g, Rhizoma Et Radix Notopterygii 1.3g
Preparation method:
1) bulk pharmaceutical chemicals are weighed, are crushed, 80 meshes are crossed；
2) vaseline is added to 1000g, stirs evenly to obtain the final product.
Embodiment 3
Formula:
Radix achyranthis bidentatae 15, rheum officinale 15g, Radix Angelicae Sinensis (tail) 15g, curcuma zedoary 15g, trigone 15g, myrrh (vinegar system) 0.8g, olibanum (vinegar system)
2g, Cortex Phellodendri 11g, radix fici simplicissimae 11g, hypericum japonicum 13g, Thickleaf Croton Root 15g, radix paeoniae rubra 11g, rhizome of davallia 11g, teasel root 15g, root of Dahurain angelica 15g,
Caulis trachelospermi 11g, radix saposhnikoviae 11g, Chinese sumac 15g, root of three-nerved spicebush 11g, herba lysimachiae 11g, schizonepeta 8g, Herba Lycopi 15g, safflower 2g, Radix Angelicae Pubescentis 2g, Qiang
0.8g, menthol 40g, III 60g of acrylic resin living
Preparation method:
1) bulk pharmaceutical chemicals are weighed, crush, with 5 times amount 80% alcohol dipping 48 hours, filtration, collection maceration extract；
2) maceration extract is concentrated under reduced pressure into 600g, and menthol is added, and dissolves, for use；
3) it after separately taking acrylic resin III to be dissolved with 95% ethyl alcohol 300g, is added in step 2) concentrate, it is stirring while adding,
It adds 70% ethyl alcohol again and adds to 1000g to obtain the final product.
Embodiment 4
Formula:
Radix achyranthis bidentatae 13g, rheum officinale 13g, Radix Angelicae Sinensis (tail) 13g, curcuma zedoary 13g, trigone 13g, myrrh (vinegar system) 1.3g, olibanum (vinegar system)
1.3g, Cortex Phellodendri 13g, radix fici simplicissimae 13g, hypericum japonicum 13g, Thickleaf Croton Root 13g, radix paeoniae rubra 13g, rhizome of davallia 13g, teasel root 13g, the root of Dahurain angelica
13g, caulis trachelospermi 13g, radix saposhnikoviae 13g, Chinese sumac 13g, root of three-nerved spicebush 13g, herba lysimachiae 13g, schizonepeta 6.5g, Herba Lycopi 13g, safflower 2.5g,
Radix Angelicae Pubescentis 1.3g, Rhizoma Et Radix Notopterygii 1.3g, menthol 35g, III 55g of acrylic resin
Preparation method:
1) bulk pharmaceutical chemicals are weighed, crush, with 5 times amount 85% alcohol dipping 48 hours, filtration, collection maceration extract；
2) maceration extract is concentrated under reduced pressure into 600g, and menthol is added, and dissolves, for use；
3) it after separately taking acrylic resin III to be dissolved with 95% ethyl alcohol 300g, is added in step 2) concentrate, it is stirring while adding,
It adds 70% ethyl alcohol again and adds to 1000g to obtain the final product.
Embodiment 5
Formula:
Radix achyranthis bidentatae 11g, rheum officinale 15g, Radix Angelicae Sinensis (tail) 11g, curcuma zedoary 15g, trigone 11g, myrrh (vinegar system) 0.8g, olibanum (vinegar system)
2g, Cortex Phellodendri 11g, radix fici simplicissimae 15g, hypericum japonicum 11g, Thickleaf Croton Root 15g, radix paeoniae rubra 11g, rhizome of davallia 15g, teasel root 11g, root of Dahurain angelica 15g,
Caulis trachelospermi 11g, radix saposhnikoviae 15g, Chinese sumac 11g, root of three-nerved spicebush 15g, herba lysimachiae 11g, schizonepeta 8g, Herba Lycopi 11g, safflower 2g, Radix Angelicae Pubescentis 2g, Qiang
1g, borneol 30g, Bletilla glucomannan 35g living
Preparation method:
1) bulk pharmaceutical chemicals are weighed, crush, with 5 times amount 80% alcohol dipping 55 hours, filtration, collection maceration extract；
2) maceration extract is concentrated under reduced pressure into 600g, and borneol is added, and dissolves, for use；
3) it after separately taking Bletilla glucomannan to be dissolved with 55% ethyl alcohol 300g, is added in step 2) concentrate, it is stirring while adding, then add
75% ethyl alcohol adds to 1000g to obtain the final product.
Embodiment 6
Formula:
Radix achyranthis bidentatae 13g, rheum officinale 13g, Radix Angelicae Sinensis (tail) 13g, curcuma zedoary 13g, trigone 13g, myrrh (vinegar system) 1.3g, olibanum (vinegar system)
1.3g, Cortex Phellodendri 13g, radix fici simplicissimae 13g, hypericum japonicum 13g, Thickleaf Croton Root 13g, radix paeoniae rubra 13g, rhizome of davallia 13g, teasel root 13g, the root of Dahurain angelica
13g, caulis trachelospermi 13g, radix saposhnikoviae 13g, Chinese sumac 13g, root of three-nerved spicebush 13g, herba lysimachiae 13g, schizonepeta 6.5g, Herba Lycopi 13g, safflower 2.5g,
Radix Angelicae Pubescentis 1.3g, Rhizoma Et Radix Notopterygii 1.3g, borneol 25g, Bletilla glucomannan 40g
Preparation method:
1) bulk pharmaceutical chemicals are weighed, crush, with 5 times amount 85% alcohol dipping 55 hours, filtration, collection maceration extract；
2) maceration extract is concentrated under reduced pressure into 600g, and borneol is added, and dissolves, for use；
3) it after separately taking Bletilla glucomannan to be dissolved with 55% ethyl alcohol 300g, is added in step 2) concentrate, it is stirring while adding, then add
75% ethyl alcohol adds to 1000g to obtain the final product.
The experimental test result of bone fracture bruise external preparation prepared by above embodiments of the present invention is as follows:
1) the bone fracture bruise external preparation dermal toxicity and irritation test prepared by embodiment: healthy SD rat 84 is taken
Only, half male and half female is randomly divided into 7 groups；Two groups are all provided with 2 subgroups: intact skin subgroup, damaged skin subgroup, every subgroup each 6
Only.It loses hair or feathers respectively 40cm in rat back backbone two sides for 24 hours before administration2, damaged skin subgroup is then with sterilizing syringe needle picture " well " word
Shape is until skin oozing of blood.Except blank control group, it is (daily and clear every time that Examples 1 to 6 sample is uniformly applied to hair removal section respectively
It is smeared after washing primary).Dermal toxicity: hair removal section, observation weight and eye, hair, skin 12,24, are cleaned after 48,72h and 7d
The performance of the toxicity such as the variation at the positions such as skin and four limbs activity, respiratory system, central nervous system.Skin irritation: 12,24,
48, hair removal section is observed after 72h and 7d, and whether there is or not the reaction of erythema, eschar or oedema and its recovery situation and times.Skin toxicology test
It observes as the result is shown: to the body quality of rat, diet, coat gloss, behavioral activity without bright after embodiment sample external application
Development is rung, and is not occurred rat cadavers in 7d, is not observed acute toxic reaction；Skin irritation test observation is as a result, implement
Example group hair removal section does not observe erythema, eschar or oedema reaction, shows that embodiment sample is nonirritant to rat skin.
2) pharmacodynamics test of the bone fracture bruise external preparation prepared by embodiment: kunming mice 70 are taken, internal diameter is used
3cm, the cylinder of long 27cm vertically pushes down the left back foot of mouse, then vertically strike mouse is sufficient from top to bottom out of cylinder with 200g counterweight
Left back vola pedis acute traumatic blood stasis is caused in foot plantar.Mouse is randomly divided into 7 groups, every group 10 by weight, gender after moulding
Only, blank control group is removed, after 1h starts that embodiment sample 1~6 is administered respectively, external application, drug is applied to the left back vola pedis hemostasis of mouse
At swelling, daily administration 2 times, continuous 5d.2h after the last administration puts to death mouse, cuts left and right foot at 4mm on ankle-joint and claims
Weight, difference is swelling expansibility, and observes ecchymosis resolution time.Embodiment prepares sample with good detumescence as the result is shown
Except stasis of blood effect, concrete outcome such as table 1:
Table 1
3) pharmacodynamics test of the bone fracture bruise external preparation prepared by embodiment: taking kunming mice 70, and random 7 groups,
Every group 10.The pain threshold of each mouse is measured before medication with hot plate method.Except blank control group, each two hind leg of mouse is smeared respectively to be given
Embodiment sample 1~6 is given, 20 minutes reusable heat plate methods measure the pain threshold of each mouse respectively after administration.The result shows that embodiment group
With apparent analgesic activity, concrete outcome see the table below 2.
Table 2
| Group | The preceding threshold of pain (s) is administered | The preceding threshold of pain (s) is administered |
| Blank control group | 27.7 | 28.1 |
| Embodiment 1 | 26.9 | 37.7 |
| Embodiment 2 | 27.7 | 36.9 |
| Embodiment 3 | 28.2 | 38.2 |
| Embodiment 4 | 29.5 | 37.0 |
| Embodiment 5 | 27.1 | 39.1 |
| Embodiment 6 | 28.1 | 41.4 |
4) clinical application of the bone fracture bruise external preparation prepared by embodiment: 360 bruises and sprains, muscles and bones are accepted in outpatient service for medical treatment
Damage, the product diseases patient such as swelling due to stasis are divided into two groups, every group of 120 people, give embodiment 2,4 and 6 respectively and prepare sample, and daily 2
It is secondary, continue 10 days or to clinical recovery, clinical effectiveness is shown: above-mentioned case being treated using embodiment sample, cure rate is 80%
More than, it is significant in efficacy, irritative response is showed no to normal and damaged skin, skin hypersensitivity reaction is also there are no, uses
Safety.Concrete outcome see the table below 3.
Table 3
| Group | It fully recovers (%) | Effectively (%) | (%) in vain |
| Embodiment 2 | 80.8 | 19.2 | 0 |
| Embodiment 4 | 83.3 | 16.7 | 0 |
| Embodiment 6 | 90.0 | 10.0 | 0 |
Claims (10)
1. a kind of bone fracture bruise external preparation, it is characterised in that: the bulk pharmaceutical chemicals of the external preparation are according to the mass fraction, comprising:
11~15 parts of radix achyranthis bidentatae, 11~15 parts of rheum officinale, 11~15 parts of radix angelicae sinensis, 11~15 parts of curcuma zedoary, 11~15 parts of trigone, vinegar myrrh
0.8~2 part, 0.8~2 part of vinegar frankincense, 11~15 parts of Cortex Phellodendri, 11~15 parts of radix fici simplicissimae, 11~15 parts of hypericum japonicum, Thickleaf Croton Root
11~15 parts, 11~15 parts of radix paeoniae rubra, 11~15 parts of the rhizome of davallia, 11~15 parts of teasel root, 11~15 parts of the root of Dahurain angelica, caulis trachelospermi 11~15
Part, windproof 11~15 parts, 11~15 parts of Chinese sumac, 11~15 parts of the root of three-nerved spicebush, 11~15 parts of herba lysimachiae, 5~8 parts of schizonepeta, Herba Lycopi 11
~15 parts, 2~4 parts of safflower, 0.8~2 part of Radix Angelicae Pubescentis, 0.8~2 part of Rhizoma Et Radix Notopterygii.
2. bone fracture bruise external preparation as described in claim 1, it is characterised in that: the bulk pharmaceutical chemicals of the external preparation press quality
Number meter, comprising: 13 parts of radix achyranthis bidentatae, 13 parts of rheum officinale, 13 parts of radix angelicae sinensis, 13 parts of curcuma zedoary, 13 parts of trigone, 1.3 parts of vinegar myrrh, vinegar system
1.3 parts of olibanum, 13 parts of radix fici simplicissimae, 13 parts of hypericum japonicum, 13 parts of Thickleaf Croton Root, 13 parts of radix paeoniae rubra, 13 parts of the rhizome of davallia, continues at 13 parts of Cortex Phellodendri
Disconnected 13 parts, 13 parts of the root of Dahurain angelica, 13 parts of caulis trachelospermi, 13 parts of radix saposhnikoviae, 13 parts of Chinese sumac, 13 parts of the root of three-nerved spicebush, 13 parts of herba lysimachiae, 6.5 parts of schizonepeta,
13 parts of Herba Lycopi, 2.5 parts of safflower, 1.3 parts of Radix Angelicae Pubescentis, 1.3 parts of Rhizoma Et Radix Notopterygii.
3. bone fracture bruise external preparation as claimed in claim 1 or 2, it is characterised in that: the external preparation be ointment or
Plastics.
4. bone fracture bruise external preparation as claimed in claim 3, it is characterised in that: contain vaseline in the ointment.
5. bone fracture bruise external preparation as claimed in claim 3, it is characterised in that: promote in the plastics containing Transdermal absorption
Into agent and filmogen, the skin penetration enhancer be menthol or borneol, the filmogen be acrylic resin III or
Bletilla glucomannan.
6. bone fracture bruise external preparation as claimed in claim 5, it is characterised in that: contain according to the mass fraction in the plastics
There are 30~40 parts of menthol, III 50~60 parts of acrylic resin.
7. bone fracture bruise external preparation as claimed in claim 5, it is characterised in that: contain according to the mass fraction in the plastics
There are 20~30 parts of borneol, 35~45 parts of Bletilla glucomannan.
8. bone fracture bruise external preparation as claimed in claim 7, it is characterised in that: the Bletilla glucomannan is made as follows
It is standby:
1) bletilla striata crushes, and 5 times of amount water are added, and ultrasound is impregnated 6 hours；
2) it filters, takes filtrate, add ethyl alcohol to ethanol content 70%, place 8 hours；
3) filter, sediment with 1 times amount 95% alcohol solution dipping 2 hours, filter, drain, 65 DEG C obtained by drying.
9. the preparation method of bone fracture bruise external preparation as claimed in claim 4, it is characterised in that: comprise the following steps:
1) bulk pharmaceutical chemicals are weighed, are crushed, 80 meshes are crossed；
2) vaseline is added, stirs evenly to obtain the final product.
10. the preparation method of bone fracture bruise external preparation as claimed in claim 5, it is characterised in that: comprise the following steps:
1) bulk pharmaceutical chemicals are weighed, are crushed, with 5 times of amounts 80~90% alcohol dipping 48 hours or more, maceration extract is collected in filtration；
2) maceration extract is concentrated under reduced pressure into 600 parts by weight, and skin penetration enhancer is added, and dissolves, for use；
3) it after separately filmogen being taken to be dissolved with ethanol water, is added in step 2) concentrate, it is stirring while adding, then add ethyl alcohol
Aqueous solution to 1000 parts by weight to obtain the final product.
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| CN118203639A (en) * | 2024-03-26 | 2024-06-18 | 东莞市中医院 | A bone injury gel plaster and its preparation method |
Citations (1)
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| CN104940796A (en) * | 2014-03-24 | 2015-09-30 | 姚震威 | Traditional Chinese medicine composition for promoting blood circulation to remove blood stasis and relieving swelling and pain |
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| CN104940796A (en) * | 2014-03-24 | 2015-09-30 | 姚震威 | Traditional Chinese medicine composition for promoting blood circulation to remove blood stasis and relieving swelling and pain |
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| 刘元等: "跌打扭伤灵酊的药效学研究", 《中国实验方剂学杂志》 * |
| 王钦等: "复方甲硝唑克林霉素乳膏的皮肤刺激性致敏试验及离体透皮释药特性", 《中国医院药学杂志》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN118203639A (en) * | 2024-03-26 | 2024-06-18 | 东莞市中医院 | A bone injury gel plaster and its preparation method |
| CN118203639B (en) * | 2024-03-26 | 2024-11-05 | 东莞市中医院 | Gel emplastrum for bone injuries and injuries from falls and preparation method thereof |
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Application publication date: 20190621 |