CN109900780A - The online pretreating device of hair sample sample introduction - Google Patents
The online pretreating device of hair sample sample introduction Download PDFInfo
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- CN109900780A CN109900780A CN201910261433.5A CN201910261433A CN109900780A CN 109900780 A CN109900780 A CN 109900780A CN 201910261433 A CN201910261433 A CN 201910261433A CN 109900780 A CN109900780 A CN 109900780A
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Abstract
The embodiment of the invention provides a kind of online pretreating devices of hair sample sample introduction, for the transmitting to hair sample in pretreatment process, the pretreating device of the hair sample sample introduction includes visual detector, mass spectrometer, object lens and sample bin component, the sample bin component includes sample cavity and the flat panel drawer that is arranged in the sample cavity, the flat panel drawer slidably passes in and out the sample cavity, the object lens are connected between the mass spectrometer and the sample bin component, image under object lens is transmitted to external equipment after being shot by imaging sensor.The present invention can be realized in hair drugs or its Metabolite fast qualitative it is quantitative, direct injected to flight time mass spectrum carries out qualitative, then triple level four bars mass spectrums of connecting quantify, and sensitivity improves, and it is fast to detect speed.
Description
Technical field
The present invention relates to the illicit drugs inspection technical field in hair, the online pre-treatment of espespecially a kind of hair sample sample introduction is filled
It sets.
Background technique
Human injection or after consuming illegal drugs, other than by urine, other such as hair, sweat, excrement, tear, nail or
Mostly or less all can be containing the once metabolin of used drug or the drug, therefore all can serve as the evidence of illicit drugs inspection.Its
As long as middle hair is not cut, the course that subject consumes illegal drugs in over the past several months can completely be presented, be considered as most having at present
One of method of effect.
Prior art discloses a kind of in-out apparatus of MALDI TOF MS instrument sample target, the skills
Art is mounted with two-dimensional surface mobile mechanism in vacuum cavity, and connecting rod jacking mechanism is mounted on the mobile platform, realizes
Taking and placing sample, sample room keep vacuum state.The technology is first used for the fast qualitative of the macromoleculars such as bacterium, to patient's infection
It is which kind of bacterium can quickly determine, but the technology but and is not suitable for for the qualitative of drugs in hair or drugs metabolin.
Summary of the invention
In view of this, in order to solve the above-mentioned technical problems, the present invention provides a kind of online preceding places of hair sample sample introduction
Manage device, can be realized in hair drugs or its Metabolite fast qualitative it is quantitative, use suitable hair sample sample introduction
Online pretreating device, then direct injected to flight time mass spectrum carries out qualitative, then the triple level four bars mass spectrums of connecting carry out
It is quantitative.The present invention may be implemented in a hair drugs and its metabolin detect, sensitivity improve, detect speed
Fastly.And during handling for drug addict's case, the time of handling a case of public security, which needs to control, obtained suspect in 24 hours
The evidence consumed illegal drugs.
A kind of online pretreating device of hair sample sample introduction provided in an embodiment of the present invention is used for hair sample preceding
Transmitting in treatment process, the pretreating device of the hair sample sample introduction include visual detector, mass spectrometer, object lens and sample
Product storehouse component, the sample bin component include sample cavity and the flat panel drawer that is arranged in the sample cavity, the flat panel drawer
The sample cavity is slidably passed in and out, the object lens are connected between the mass spectrometer and the sample bin component, under object lens
Image shot by imaging sensor after be transmitted to external equipment.
Preferably, the flat panel drawer side includes putting article slot and fixed sample disc, is arranged in the sample disc several
It is a to put article slot, it puts described in each and silica gel matrix is set in article slot, hair sample is fixed on the silica gel matrix of sample disc,
The sample disc is fixed.
Preferably, the flat panel drawer other side setting horizontal direction sliding rail and vertical direction sliding rail, the horizontal direction
Sliding rail and vertical direction sliding rail be arranged in the flat panel drawer by near part, the flat panel drawer can pass through the horizontal direction
Sliding rail and vertical direction sliding rail move in the sample cavity, to cooperate samples such as hairs by sending in the sample cavity
Out, it can be achieved that the disengaging of sample and the movement of test position
Preferably, the mass spectrometer includes the triple level four bars matter of ground substance assistant laser analysis flight time mass spectrum series connection
Spectrum, the ratio between mass number scanning range quality charge of the flight time mass spectrum part (m/z) is fixed to 0 to 2000, to quality
50 to 1000 range of the ratio between charge (m/z) optimizes, and triple level four bars mass spectrums of connecting on time of-flight mass spectrometer pass through
Choice ion pattern carries out accurate quantitative analysis to ingredient to be measured.
Preferably, the object lens wait the detection of detection article progress repeatedly to the hair, after repetition test really
Surely suitable amplification factor, is transmitted to computer after the image under object lens is shot by imaging sensor, while can be
Laser spot position when laser desorption under the object lens visual field is set on computer.
Preferably, the online pretreating device of the hair sample sample introduction further includes that gas channels and the connection gas circuit are logical
The six-way valve in road, the gas channels are three, are respectively to vacuumize gas circuit, gas transport gas circuit and inert gas gas circuit.
Preferably, the described gas circuit one end that vacuumizes is connected to the sample cavity, and the other end connects on the six-way valve, described
It vacuumizes gas circuit to be connected to by the six-way valve on external vacuum pumping pump, to be vacuumized to the sample cavity, guarantee
The vacuum environment of the sample cavity provides test environment for sample detection.
Preferably, sample cavity described in inert gas gas circuit one end is connected to, and the other end connects on the six-way valve, described
Inert gas gas circuit is by the inert gas outside six-way valve connection, to carry out inert gas input to the sample cavity,
Reaction condition is provided for sample detection.
Preferably, sample cavity described in gas transport gas circuit one end is connected to, and the other end connects on the six-way valve, described
Gas transport gas circuit is connected by the gas device outside six-way valve connection, to dredge to the gas in the sample cavity
It leads.
Preferably, the external equipment can be thought as the intelligent computer with image processing function.
Other features and advantages of the present invention will be illustrated in the following description, also, partly becomes from specification
It obtains it is clear that understand through the implementation of the invention.The objectives and other advantages of the invention can be by specification, right
Specifically noted structure is achieved and obtained in claim and attached drawing.
Detailed description of the invention
In order to illustrate the technical solution of the embodiments of the present invention more clearly, below will be to needed in the embodiment attached
Figure is briefly described, it should be understood that the following drawings illustrates only certain embodiments of the present invention, therefore is not construed as pair
The restriction of range for those of ordinary skill in the art without creative efforts, can also be according to this
A little attached drawings obtain other relevant attached drawings.
Fig. 1 is a kind of structural representation of the online pretreating device for hair sample sample introduction that present pre-ferred embodiments provide
Figure；
Fig. 2 is the flat panel drawer front view of the online pretreating device of the hair sample sample introduction in Fig. 1；
Fig. 3 is the flat panel drawer top view of the online pretreating device of the hair sample sample introduction in Fig. 1；
Fig. 4 is the method and step figure of the online pretreating device of hair sample sample introduction of the invention.
Main element symbol description
The online pretreating device 100 of hair sample sample introduction；Visual detector 10；Mass spectrometer 20；Object lens 30；Sample bin
Component 40；Sample cavity 401；Flat panel drawer 402；Sample disc 403；Put article slot 404；Horizontal direction sliding rail 405；Vertical direction is sliding
Rail 406；Gas channels 50；Six-way valve 60；Vacuumize gas circuit 501；Gas transport gas circuit 503；Inert gas gas circuit 502.
Specific embodiment
In order to make the object, technical scheme and advantages of the embodiment of the invention clearer, below in conjunction with the embodiment of the present invention
In attached drawing, technical scheme in the embodiment of the invention is clearly and completely described, it is clear that described embodiment is
A part of the embodiment of the present invention, instead of all the embodiments.The present invention being usually described and illustrated herein in the accompanying drawings is implemented
The component of example can be arranged and be designed with a variety of different configurations.
Therefore, the detailed description of the embodiment of the present invention provided in the accompanying drawings is not intended to limit below claimed
The scope of the present invention, but be merely representative of selected embodiment of the invention.Based on the embodiments of the present invention, this field is common
Technical staff's every other embodiment obtained without creative efforts belongs to the model that the present invention protects
It encloses.
Please refer to Fig. 1 of the invention, a kind of online pretreating device 100 for hair sample sample introduction of the invention,
Including visual detector (Charge-coupled Device, CCD) 10, mass spectrometer 20, object lens 30 and the sample set gradually
Storehouse component 40.The ccd image sensor 10 can directly convert optical signals into analog current signal, and current signal is through over-discharge
Big and analog-to-digital conversion, realizes acquisition, storage, transmission, processing and the reproduction of image.Present embodiment, the ccd image sensor
Captured electronic image output can be uploaded to computer and analyzed by 10 with external computer connection communication.In Fig. 1 simultaneously
The schematic diagram of computer is not shown, it is possible to understand that ground, the computer can be the equipment with image processing function, such as intelligence meter
Calculation machine etc..
The mass spectrometer 20 includes the triple level four bars mass spectrums of ground substance assistant laser analysis flight time mass spectrum series connection, matrix
Auxiliary laser analysis flight time mass spectrum mainly consist of two parts: matrix-assisted laser desorption ionization ion source (MALDI) and
Time-of-flight mass analyzer (TOF), the principle of MALDI are with laser irradiation sample and substrate formed cocrystallization film, base
Matter absorbs energy transmission to biomolecule from laser, and by proton translocation to biomolecule or from biomolecule in ionization process
The process for obtaining proton, and ionizing biomolecule.Therefore it is a kind of Soft ionization techniques, is suitable for mixture and big point of biology
The measurement of son.The principle of TOF is that ion accelerates to fly over dirft tube under electric field action, according to the flight time for reaching detector
Mass-to-charge ratio (M/Z) that is different and being detected i.e. measurement ion is directly proportional to the flight time of ion, detects ion.
Basic principle is that sample dispersion in substrate molecule and is formed crystal.When with laser irradiation crystal, matrix from
Absorb energy in laser, sample desorption occurs electric charge transfer between matrix-sample and makes ionized sample molecule, the sample of ionization
Product fly over the tof tube of vacuum under electric field action, different according to the flight time for reaching detector and be detected, i.e., by from
The ratio between the quality charge (M/Z) of son is directly proportional to the flight time of ion to analyze ion, and measures the molecular weight of sample molecule.
Triple level four bars mass spectrographs usually across for making the collision cell of ionic dissociation by collision induced dissociation,
Has quadrupole mass filter respectively before and after it.Then, in prime quadrupole mass filter, from from target compound it is various from
Selection has the precursor ion of specific mass-to-charge ratio in son, and in rear class quadrupole mass filter, generation is separated according to mass-to-charge ratio before
The various product ions of body ion.Collision cell is the relatively high box-like structural body of airtightness, and argon gas etc. is touching for inert gas
Gas is hit to be fed to inside it.The precursor ion chosen through prime quadrupole mass filter has collision energy appropriate and quilt
It is directed into collision cell, is collided in collision cell with collision gas and generate collision induced dissociation, generate product ion.
The object lens 30 are connected between the mass spectrometer 20 and the sample bin component 40, such as hair etc. is to be detected
Article is accommodated in the sample bin component 40, and the object lens 30 wait the detection of detection article progress repeatedly to the hair,
Suitable amplification factor is determined after repetition test, the online pretreating device 100 of the hair sample sample introduction, which configures, to be fixed
Object lens 30, be transmitted to computer after the image under object lens 30 is shot by ccd image sensor 10, while can be in electricity
Laser spot position when laser desorption under 30 visual field of object lens is set on brain.By experiment, determine laser uses power, passes through
Adjustment, so that computer-controlled laser position and practical laser position are no more than 1 μm.
The sample bin component 40 includes sample cavity 401 and the flat panel drawer 402 being arranged in the sample cavity 401, asks
In conjunction with referring to figs. 2 and 3, in present embodiment, the sample cavity 401 is the vacuum sample cavity using small size, by hair
Equal samples are adsorbed in fixed sample disc, and the object lens 30 are installed at the top in sample cavity 401.The flat panel drawer 402 1
Side includes putting article slot 404 and fixed sample disc 403, several are arranged in the sample disc 403 and puts article slot 404, each
It puts and silica gel matrix is set in article slot 404, hair sample is fixed on the silica gel matrix of sample disc 403, and sample disc 403 is fixed not
It is dynamic, it is mobile not need two-dimensional surface.402 other side of the flat panel drawer setting horizontal direction sliding rail 405 and vertical direction sliding rail
406, the horizontal direction sliding rail 405 and vertical direction sliding rail 406 be arranged in the flat panel drawer 402 by near part, it is described
Flat panel drawer 402 can be moved in the sample cavity 401 by the horizontal direction sliding rail 405 and vertical direction sliding rail 406, with
Cooperation sends out the samples such as hair, it can be achieved that the disengaging of sample and the movement of test position by being sent into the sample cavity 401.
The online pretreating device 100 of the hair sample sample introduction further includes gas channels 50 and the connection gas channels
50 six-way valve 60, it is respectively to vacuumize gas circuit 501, gas transport that in present embodiment, the gas channels 50, which are three,
Gas circuit 503 and inert gas gas circuit 502.Described 501 one end of gas circuit that vacuumizes is connected to the sample cavity 401, other end connection
On the six-way valve 60, the connection of sample cavity 401 described in described 503 one end of gas transport gas circuit, the other end connects the six-way valve
On 60, the connection of sample cavity 401 described in described 502 one end of inert gas gas circuit, the other end is connected on the six-way valve 60.The pumping
Vacuum air-channel 501 is connected on external vacuum pumping pump by the six-way valve 60, true take out to the sample cavity 401
Sky, guarantees the vacuum environment of the sample cavity 401, provides test environment for sample detection.The inert gas gas circuit 502 passes through
The six-way valve 60 connects external inert gas, to carry out inert gas input to the sample cavity 401, mentions for sample detection
For reaction condition, the gas transport gas circuit 503 connects external gas device by the six-way valve 60 and connects, to described
Gas in sample cavity 401 is dredged.After sample enters sample cavity 401, the gas channels 50 lead to described six
Valve 60 provides vacuum detecting condition with the sample is combined into.
It is further illustrated below with reference to Fig. 4 and detects hair using the online pretreating device 100 of the hair sample sample introduction
Detecting step when sample: hair sample is absorbed and fixed in sample disc 403 first, it should be noted that in the present embodiment
Hair sample can be one, it is described detection drugs device 100 may be implemented in a hair sample drugs and its generation
It thanks to object to be detected, high sensitivity, detection speed is fast, the existing detection to drug ingredient and its metabolin in hair, often
Part sample is in great demand, and pretreatment process complexity is cumbersome, and consumptive material and cost of labor are higher, the time to be treated compared with
It is long.The sample disc 403 is fixed on the flat panel drawer 402, and the flat panel drawer 402 passes through the horizontal direction sliding rail
405 and vertical direction sliding rail 406 realize sample disengaging and test position movement.
Followed by object lens 30 adjust the process of amplification factor, i.e., suitable amplification factor is determined after repetition test.It connects
Get off, image transmitting under 30 object lens of object lens is gone out to computer, while swashing for laser desorption under the object lens visual field can be set on computers
Luminous point determines that laser uses power by test；By adjustment, computer-controlled laser position and actual laser position.
Finally, the mass number scanning range m/z of flight time mass spectrum part is fixed to 0 to 2000, to m/z 50 to
1000 ranges optimize, and improve sensitivity.Connect on time of-flight mass spectrometer triple level four bars mass spectrums, by selection from
Subpattern carries out accurate quantitative analysis to ingredient to be measured.
Using the online pretreating device 100 of suitable hair sample sample introduction, can direct injected to flight time mass spectrum carry out
It is qualitative, then triple level four bars mass spectrums of connecting are quantified.Further plan is optimization flight time mass spectrum, can be straight
Accurate quantitative analysis is connect, triple level four bars mass spectrums are quantified without connecting again.
During handling for drug addict's case, the time of handling a case of public security, which needs to control, obtained suspect in 24 hours
The evidence that member consumes illegal drugs, after the present invention greatly shortens detection time, personnel in charge of the case being capable of the fastest acquisition suspect
The evidence whether member takes drugs.Simultaneously in banning drugs work, the invention can be used and carry out large-scale personnel's drug abuse investigation, to the prohibition of drug
Work belt greatly helps.
Method and apparatus are provided for the embodiments of the invention above to be described in detail, it is used herein specifically a
Principle and implementation of the present invention are described for example, and it is of the invention that the above embodiments are only used to help understand
Method and its core concept；At the same time, for those skilled in the art, according to the thought of the present invention, in specific embodiment party
There will be changes in formula and application range, in conclusion the contents of this specification are not to be construed as limiting the invention.
Claims (10)
1. a kind of pretreating device of hair sample sample introduction, for the transmitting to hair sample in pretreatment process, feature
It is, the pretreating device of the hair sample sample introduction includes visual detector, mass spectrometer, object lens and sample bin component, institute
The flat panel drawer that sample bin component includes sample cavity He is arranged in the sample cavity is stated, the flat panel drawer slidably passes in and out
The sample cavity, the object lens are connected between the mass spectrometer and the sample bin component, and the image under object lens passes through figure
External equipment is transmitted to after being shot as sensor.
2. the pretreating device of hair sample sample introduction as described in claim 1, which is characterized in that the flat panel drawer side packet
It includes and puts article slot and fixed sample disc, several are set in the sample disc and puts article slot, put in article slot described in each and set
Silica gel matrix is set, hair sample is fixed on the silica gel matrix of sample disc, and the sample disc is fixed.
3. the pretreating device of hair sample sample introduction as claimed in claim 2, which is characterized in that the flat panel drawer other side
Horizontal direction sliding rail and vertical direction sliding rail are set, and the horizontal direction sliding rail and the setting of vertical direction sliding rail are taken out in the plate
Drawer leans near part, and the flat panel drawer can be moved in the sample cavity by the horizontal direction sliding rail and vertical direction sliding rail
It is dynamic, the samples such as hair are sent out by being sent into the sample cavity, it can be achieved that the disengaging of sample and the movement of test position with cooperation.
4. the pretreating device of hair sample sample introduction as described in claim 1, which is characterized in that the mass spectrometer includes base
Matter auxiliary laser analyzes the triple level four bars mass spectrums of flight time mass spectrum series connection, the mass number scanning of the flight time mass spectrum part
The ratio between range quality charge (m/z) is fixed to 0 to 2000, optimizes to 50 to 1000 range of the ratio between quality charge (m/z),
It connects on time of-flight mass spectrometer triple level four bars mass spectrums, by choice ion pattern, accurate quantitative analysis is carried out to ingredient to be measured.
5. the pretreating device of hair sample sample introduction as described in claim 1, which is characterized in that the object lens are to the hair
The detection of detection article progress repeatedly is waited, suitable amplification factor is determined after repetition test, the image under object lens is led to
Cross after imaging sensor is shot and be transmitted to computer, at the same can be arranged on computers under the object lens visual field laser desorption when swash
Light spot position.
6. the pretreating device of hair sample sample introduction as described in claim 1, which is characterized in that the hair sample sample introduction
Online pretreating device further includes gas channels and the six-way valve for connecting the gas channels, and the gas channels are three,
Respectively vacuumize gas circuit, gas transport gas circuit and inert gas gas circuit.
7. the pretreating device of hair sample sample introduction as claimed in claim 6, which is characterized in that described to vacuumize gas circuit one end
It is connected to the sample cavity, the other end connects on the six-way valve, and the gas circuit that vacuumizes is connected to outside by the six-way valve
On the vacuum pumping pump in portion, to be vacuumized to the sample cavity, guarantees the vacuum environment of the sample cavity, mentioned for sample detection
For testing environment.
8. the pretreating device of hair sample sample introduction as claimed in claim 6, which is characterized in that the inert gas gas circuit one
The sample cavity is held to be connected to, the other end connects on the six-way valve, and the inert gas gas circuit is outer by six-way valve connection
The inert gas in portion provides reaction condition to carry out inert gas input to the sample cavity for sample detection.
9. the pretreating device of hair sample sample introduction as claimed in claim 6, which is characterized in that the gas transport gas circuit one
The sample cavity is held to be connected to, the other end connects on the six-way valve, and the gas transport gas circuit is outer by six-way valve connection
The gas device in portion connects, to dredge the gas in the sample cavity.
10. the pretreating device of hair sample sample introduction as described in claim 1, which is characterized in that the external equipment can be with
To be the intelligent computer with image processing function.
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| CN201910261433.5A CN109900780A (en) | 2019-04-02 | 2019-04-02 | The online pretreating device of hair sample sample introduction |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110530966A (en) * | 2019-09-25 | 2019-12-03 | 清华大学 | A visual array type high-throughput mass spectrometry detection device and method |
| CN110988207A (en) * | 2019-12-17 | 2020-04-10 | 厦门历思科技服务有限公司 | Monitoring method based on human body intake substance detection |
| CN110988205A (en) * | 2019-11-26 | 2020-04-10 | 厦门历思科技服务有限公司 | Novel method for detecting substance intake and intake frequency of human body |
| CN113834868A (en) * | 2021-09-06 | 2021-12-24 | 宁波盘福生物科技有限公司 | Device and method for rapidly detecting drugs in hair |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1601268A (en) * | 2004-10-22 | 2005-03-30 | 厦门大学 | An electronically conductive polymer film electrode for hydroquinone detection and its preparation method |
| US20060284078A1 (en) * | 2003-05-30 | 2006-12-21 | Overney Gregor T | Apparatus and method for maldi source control with external image capture |
| WO2008068847A1 (en) * | 2006-12-05 | 2008-06-12 | Shimadzu Corporation | Mass spectroscope |
| CN102192962A (en) * | 2010-03-18 | 2011-09-21 | 复旦大学 | Laser-assisted thermal resolution mass spectrum feeding device and method |
| CN103575848A (en) * | 2013-11-11 | 2014-02-12 | 厦门出入境检验检疫局检验检疫技术中心 | Method for determining migration quantity of volatile organic compounds in adhesive sticker for food label in water-based food simulating object |
| CN204758530U (en) * | 2015-06-30 | 2015-11-11 | 厦门质谱仪器仪表有限公司 | Microorganism identification package |
| CN108022822A (en) * | 2017-12-06 | 2018-05-11 | 江苏天瑞仪器股份有限公司福建分公司 | The in-out apparatus of MALDI TOF MS instrument sample target |
-
2019
- 2019-04-02 CN CN201910261433.5A patent/CN109900780A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060284078A1 (en) * | 2003-05-30 | 2006-12-21 | Overney Gregor T | Apparatus and method for maldi source control with external image capture |
| CN1601268A (en) * | 2004-10-22 | 2005-03-30 | 厦门大学 | An electronically conductive polymer film electrode for hydroquinone detection and its preparation method |
| WO2008068847A1 (en) * | 2006-12-05 | 2008-06-12 | Shimadzu Corporation | Mass spectroscope |
| CN102192962A (en) * | 2010-03-18 | 2011-09-21 | 复旦大学 | Laser-assisted thermal resolution mass spectrum feeding device and method |
| CN103575848A (en) * | 2013-11-11 | 2014-02-12 | 厦门出入境检验检疫局检验检疫技术中心 | Method for determining migration quantity of volatile organic compounds in adhesive sticker for food label in water-based food simulating object |
| CN204758530U (en) * | 2015-06-30 | 2015-11-11 | 厦门质谱仪器仪表有限公司 | Microorganism identification package |
| CN108022822A (en) * | 2017-12-06 | 2018-05-11 | 江苏天瑞仪器股份有限公司福建分公司 | The in-out apparatus of MALDI TOF MS instrument sample target |
Non-Patent Citations (2)
| Title |
|---|
| 李力 等: "《医学实验室高端仪器设备标准操作规程》", 30 June 2015, 广西科学技术出版社 * |
| 李力 等: "《实用生物医学概论教程》", 31 July 2016, 广西科学技术出版社 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110530966A (en) * | 2019-09-25 | 2019-12-03 | 清华大学 | A visual array type high-throughput mass spectrometry detection device and method |
| CN110988205A (en) * | 2019-11-26 | 2020-04-10 | 厦门历思科技服务有限公司 | Novel method for detecting substance intake and intake frequency of human body |
| CN110988207A (en) * | 2019-12-17 | 2020-04-10 | 厦门历思科技服务有限公司 | Monitoring method based on human body intake substance detection |
| CN113834868A (en) * | 2021-09-06 | 2021-12-24 | 宁波盘福生物科技有限公司 | Device and method for rapidly detecting drugs in hair |
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Application publication date: 20190618 |