CN109887822B - Novel sleeve type ion migration tube - Google Patents
Novel sleeve type ion migration tube Download PDFInfo
- Publication number
- CN109887822B CN109887822B CN201711272311.3A CN201711272311A CN109887822B CN 109887822 B CN109887822 B CN 109887822B CN 201711272311 A CN201711272311 A CN 201711272311A CN 109887822 B CN109887822 B CN 109887822B
- Authority
- CN
- China
- Prior art keywords
- electrode
- sleeve
- separation
- detection
- pair
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000013508 migration Methods 0.000 title description 11
- 230000005012 migration Effects 0.000 title description 11
- 238000000926 separation method Methods 0.000 claims abstract description 91
- 238000001514 detection method Methods 0.000 claims abstract description 89
- 238000012546 transfer Methods 0.000 claims abstract description 14
- 150000001875 compounds Chemical class 0.000 abstract description 9
- 238000012545 processing Methods 0.000 abstract description 3
- 230000003595 spectral effect Effects 0.000 abstract 1
- 150000002500 ions Chemical class 0.000 description 61
- 230000037230 mobility Effects 0.000 description 14
- 238000004458 analytical method Methods 0.000 description 8
- 230000005684 electric field Effects 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 4
- 238000006073 displacement reaction Methods 0.000 description 3
- 230000035945 sensitivity Effects 0.000 description 3
- 239000012159 carrier gas Substances 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000001871 ion mobility spectroscopy Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000010923 batch production Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000002360 explosive Substances 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
Images
Landscapes
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Abstract
本发明公开了一种新型套筒式离子迁移管，具体讲一种套筒式高场非对称波形离子迁移管，它包括进样口、电离区、分离区、检测区等，沿轴向方向依次排列。分离区由两个及两个以上套筒电极构成；检测区由两个及两个以上套筒电极对构成。通过调控不同套筒电极的间距，可以同时实现多种化合物的同时测定；也可以获得同一种化合物在不同分离电压下的谱图信息，提高识别准确性。每本发明可以同时提供两个或两个以上的检测通道，实现两个或两个以上化合物的同时测定，缩短检测周期；使用单一的高场非对称性射频电压和直流补偿电源，不需要多个电源，结构简单、体积小，便于加工和产业化推广。
The invention discloses a novel sleeve-type ion transfer tube, in particular a sleeve-type high-field asymmetric waveform ion transfer tube, which comprises a sample inlet, an ionization zone, a separation zone, a detection zone, etc. in order. The separation area consists of two or more sleeve electrodes; the detection area consists of two or more sleeve electrode pairs. By adjusting the distances of different sleeve electrodes, the simultaneous determination of multiple compounds can be achieved; the spectral information of the same compound under different separation voltages can also be obtained to improve the identification accuracy. Each invention can provide two or more detection channels at the same time, realize the simultaneous determination of two or more compounds, and shorten the detection period; using a single high-field asymmetric radio frequency voltage and DC compensation power supply, it does not need more It is a power supply with simple structure and small volume, which is convenient for processing and industrialization promotion.
Description
Technical Field
The invention relates to an atmospheric pressure separation analysis technology, in particular to a novel sleeve type ion transfer tube, which comprises an ionization region, a separation region, a detection region and the like which are sequentially arranged along the axial direction. The separation area is composed of a central electrode and two or more than two coaxial, parallel and non-coplanar sleeve electrodes; the detection area is composed of N coaxial cylindrical electrodes which are parallel and insulated with each other. Two or more detection electrode pairs. At least one of the separated electrodes of each pair faces towards the ground electrode, and at least one electrode faces towards the high-voltage asymmetric field electrode. Each pair of detection electrodes applies a positive bias voltage to one electrode and a negative bias voltage to one electrode. The invention can utilize the same asymmetric power supply, realize the simultaneous determination of two or more compounds by regulating and controlling the distance between two or more detection channels, and shorten the detection period; the single high-field asymmetric radio frequency voltage and direct current compensation power supply are used, a plurality of power supplies are not needed, the structure is simple, the size is small, and the processing and the industrialized popularization are facilitated.
Background
The high-field asymmetric waveform ion mobility tube is a mass analysis detection technology which is continuously developed based on the traditional ion mobility spectrometry technology, and the first public report is provided by Buryakov et al, Soviet Union in 1993. It is based on ions in high field (E/N)>40Td，1Td＝10-17Vcm2) Low field (E/N)<2Td) to enable detection of different species.
The principle of asymmetric field ion mobility spectrometry is as follows: the mobility of the ions can be expressed as:
K＝K0(1+α)
wherein K is the mobility of ions in a high field, K0The value of the mobility of the ions under low field is the rate of change of the mobility of the ions under high field relative to the mobility under low field, which may be positive or negative, and varies depending on the material α is equal to 0 under low field.
The carrier gas makes the matter ion pass through the drift region in the direction perpendicular to the electric field, the drift region applies the asymmetric field switched by radio frequency positive and negative, and the time average value of the voltage is zero in the whole radio frequency period. Thus, in the high and low field regions, the ions are both vertically displaced along the electric field at mobility K, but if the mobilities at the high and low fields are different, the ions will generally move away from their original positions in a direction perpendicular to the direction during a period, resulting in a net displacement. Over time, this displacement of the ions will cause them to strike the electrodes and be neutralized. In order to make the ions pass through the detection area smoothly, a direct current electric field can be superposed on the original electric field, and when the direct current electric field is properly added, the net displacement of the ions in the vertical direction is zero, so that the ions can be detected through the detection channel smoothly. By scanning the dc field, different ions can be detected.
The high-field asymmetric waveform ion mobility tube technology has the advantages of high detection sensitivity, simple equipment, small volume, portability, low detection cost and the like, and is more and more valued by people. At present, the method can be applied to a plurality of fields such as monitoring of explosives, drug inspection, detection of biochemical warfare agents and the like. At present, the high-field asymmetric waveform ion mobility tube reported in the literature and the patent comprises a flat plate structure (200910086487.9, 201310191739.0) and a cylindrical structure (200810229883.8). Previous flat panel structure devices only enabled the detection of ions of a single polarity (electrophilic or protonophilic). In order to increase the detection speed and reduce the analysis time, patent 200810229883.8 proposes a parallel-type and series-type combined high-field asymmetric waveform ion mobility tube, which is provided with two or more ground electrode sleeves; however, the concentration of the target compound is decreased by shunting the sample, resulting in a decrease in detection sensitivity. In addition, the array structure usually needs a plurality of high-field asymmetric radio frequency voltages and a direct current compensation power supply, which is not favorable for miniaturization and industrial popularization.
The invention provides a sleeve type high-field asymmetric waveform ion transfer tube, which is processed by integrated design and uses a single high-field asymmetric radio frequency voltage and a direct current compensation power supply to realize simultaneous determination of multiple compounds, reduce analysis time and realize high-flux analysis.
Disclosure of Invention
The invention aims to provide a multi-channel sleeve type high-field asymmetric waveform ion transfer tube, and the ion transfer separation and detection channel of the transfer tube adopts a structural integrated design, so that the simultaneous detection of two channels or multiple channels is realized, the false alarm rate is reduced, and the accuracy and the application range of the instrument detection are improved.
In order to achieve the purpose, the invention adopts the technical scheme that:
the sleeve type ion migration tube comprises: the device comprises a cylindrical insulating sleeve with a closed left end and an open right end, wherein a sample inlet is arranged in the middle of the closed left end of the insulating sleeve, a central electrode is arranged in the middle of the insulating sleeve along the axis direction of the insulating sleeve, a cylindrical first separation electrode sleeve is sleeved outside the central electrode, a cylindrical second separation electrode sleeve is sleeved outside the first separation electrode sleeve, the central electrode, the first separation electrode sleeve and the second separation electrode sleeve are mutually spaced and coaxially arranged, an ion separation zone is formed by the central electrode, the first separation electrode sleeve and the second separation electrode sleeve, and an ionization source is arranged between the ion separation zone and the sample inlet; a second detection electrode pair formed by a pair of coaxially sleeved cylindrical electrodes and a first detection electrode pair formed by a pair of coaxially sleeved cylindrical electrodes sleeved outside the second detection electrode pair are arranged in the cylinder body close to the right opening end of the insulating sleeve along the axis direction of the cylinder body; the ion detection area is formed by the first detection electrode pair and the second detection electrode pair; be equipped with shielding electrode between ion separation district and ion detection district, shielding electrode includes that the middle part sets up in the middle part electrode along insulating sleeve axis direction, and the outside cover of middle part electrode is equipped with cylindric electrode, and the outside cover of electrode is equipped with cylindric two electrodes, and middle part electrode, two electrodes are mutual interval, coaxial setting.
The ion separation area of the ion migration tube is composed of a central electrode, a first separation electrode sleeve and a second separation electrode sleeve from inside to outside, the central electrode, the first separation electrode sleeve and the second separation electrode sleeve are coaxial, and the lengths of the central electrode, the first separation electrode sleeve and the second separation electrode sleeve are the same along the axial direction of the insulating sleeve; a first separation area is formed between the central electrode and the first separation electrode sleeve; a second separation area is formed between the first separation electrode sleeve and the second separation electrode sleeve; the lengths of the inner cylindrical detection electrode and the outer cylindrical detection electrode which form the first detection electrode pair and the second detection electrode pair are the same along the axial direction of the insulating sleeve; the detection electrode pair comprises a first detection electrode pair and a second detection electrode pair; each electrode pair is divided into an inner cylindrical detection electrode and an outer cylindrical detection electrode which are insulated from each other, and positive bias voltage and negative bias voltage are respectively applied to the inner detection electrode and the outer detection electrode and are respectively used for detecting positive ions and negative ions; the ionization source, the ion separation area and the ion detection area are all located inside the insulating sleeve.
The length of the middle electrode, the first electrode and the second electrode which form the shielding electrode along the axial direction of the insulating sleeve is the same.
The ion migration tube is characterized in that: the number n of the coaxially sleeved separation electrode sleeves is 2 or more than two;
when the number of the electrodes is 2, the voltages connected with the adjacent electrodes of the central electrode, the first separated electrode sleeve and the second separated electrode sleeve are different, and the voltages connected with the non-adjacent (spaced) electrodes are the same;
for example, the central electrode and the separated electrode sleeve are respectively connected with the ground wire (or a high-field asymmetric power supply and a supplementary direct-current power supply) through leads; the first split electrode sleeve is connected with a high-field asymmetric power supply and a supplementary direct current power supply (or a ground wire) through leads.
The distance between the central electrode and the first separation electrode sleeve of the ion migration tube is different from the distance between the first separation electrode sleeve and the second separation electrode sleeve; the spacing is between 0.1 and 10 mm.
The ion migration tube is characterized in that: the central or middle electrode is a cylindrical or cylindrical electrode, respectively.
The ionization source of the ion migration tube is a pair of parallel plate-shaped discharge electrodes, and the electrodes are parallel to the axial direction of the insulating sleeve (9).
The invention has the advantages that:
1. the integrally designed stepped high-field asymmetric waveform ion mobility tube is designed.
2. The multi-channel ion detector realizes multi-channel detection of positive and negative ions, can detect electrophilic substances and proton-philic substances simultaneously, not only enlarges the detection range, but also improves the detection efficiency.
3. The invention uses single high-field asymmetric radio frequency voltage and a direct current compensation power supply, has simple structure and convenient processing, and is easy for batch production;
the invention can realize two or more than two detection channels in one cavity, realize the simultaneous determination of various compounds, shorten the analysis period, improve the analysis efficiency and realize the rapid analysis of mass samples; in addition, the invention can apply different high-field asymmetric-wave radio-frequency high voltages on different electrode pairs aiming at the same compound, obtain a two-position spectrogram of the compensation voltage and the radio-frequency voltage in a short time and improve the identification accuracy. This novel asymmetric waveform ion mobility tube in high field can reduce the influence of parameters such as temperature, environment, float gas, is particularly useful for the environment of higher air humidity to the realization is to the high sensitivity and the high discernment accuracy of determinand.
Drawings
FIG. 1 is a schematic diagram of a sleeve-type high-field asymmetric waveform ion transfer tube;
Detailed Description
The schematic diagram of the sleeve type high-field asymmetric waveform ion transfer tube of the invention is shown in figure 1.
The sleeve type ion migration tube comprises: the device comprises a cylindrical insulating sleeve 9 with a closed left end and an open right end, wherein a sample inlet 8 is arranged in the middle of the closed left end of the insulating sleeve, a central electrode 4 is arranged in the middle of the insulating sleeve along the axis direction of the insulating sleeve, a cylindrical first separation electrode sleeve 3 is sleeved outside the central electrode, a cylindrical second separation electrode sleeve 2 is sleeved outside the first separation electrode sleeve, the central electrode 4, the first separation electrode sleeve 3 and the second separation electrode sleeve 2 are mutually spaced and coaxially arranged, an ion separation zone is formed by the central electrode, the first separation electrode sleeve and the second separation electrode sleeve 2, and an ionization source 1 is arranged between the ion separation zone and the sample inlet 8; a second detection electrode pair 7 formed by a pair of coaxially sleeved cylindrical electrodes and a first detection electrode pair 6 formed by a pair of coaxially sleeved cylindrical electrodes and sleeved outside the second detection electrode pair 7 are arranged in the cylinder body close to the right opening end of the insulating sleeve along the axis direction of the cylinder body; the ion detection area is formed by the first detection electrode pair and the second detection electrode pair; be equipped with shielding electrode between ion separation district and ion detection district, shielding electrode 5 includes that the middle part sets up in the middle part electrode along insulating sleeve axis direction, and the outside cover of middle part electrode is equipped with cylindric electrode, and the outside cover of electrode is equipped with cylindric two electrodes, and middle part electrode, two electrodes are mutual interval, coaxial setting.
The ion migration tube is characterized in that: the ion separation zone is composed of a central electrode, a first separation electrode sleeve and a second separation electrode sleeve from inside to outside, the central electrode, the first separation electrode sleeve and the second separation electrode sleeve are coaxial, and the lengths of the central electrode, the first separation electrode sleeve and the second separation electrode sleeve are the same along the axial direction of the insulating sleeve; a first separation area is formed between the central electrode and the first separation electrode sleeve (3); a second separation area is formed between the first separation electrode sleeve and the second separation electrode sleeve; the lengths of the inner cylindrical detection electrode and the outer cylindrical detection electrode which form the first detection electrode pair and the second detection electrode pair are the same along the axial direction of the insulating sleeve; the detection electrode pair comprises a first detection electrode pair and a second detection electrode pair; each electrode pair is divided into an inner cylindrical detection electrode and an outer cylindrical detection electrode which are insulated from each other, and positive bias voltage and negative bias voltage are respectively applied to the inner detection electrode and the outer detection electrode and are respectively used for detecting positive ions and negative ions; the ionization source, the ion separation area and the ion detection area are all located inside the insulating sleeve.
The length of the middle electrode, the first electrode and the second electrode which form the shielding electrode along the axial direction of the insulating sleeve is the same.
The ion migration tube is characterized in that: the number n of the coaxially sleeved separation electrode sleeves is 2 or more than two;
when the number of the electrodes is 2, the voltages connected with the adjacent electrodes of the central electrode, the first separated electrode sleeve and the second separated electrode sleeve are different, and the voltages connected with the non-adjacent (spaced) electrodes are the same;
for example, the central electrode and the separated electrode sleeve (3) are respectively connected with the ground wire (or a high-field asymmetric power supply and a supplementary direct-current power supply) through leads; the first separated electrode sleeve (3) is connected with a high-field asymmetric power supply and a supplementary direct current power supply (or a ground wire) through leads.
The spacing between the center electrode and the first split electrode sleeve is different from the spacing between the first split electrode sleeve and the second split electrode sleeve; the spacing is between 0.1 and 10 mm.
The central or middle electrode is a cylindrical or cylindrical electrode, respectively.
The ionization source is a pair of parallel plate-shaped discharge electrodes, and the electrodes are parallel to the axial direction of the insulating sleeve (9).
During measurement, a sample enters the ionization source 2 through the air inlet 8 under the carrying effect of carrier gas and is ionized; then enters a first separation area formed between the central electrode 4 and the first separation electrode sleeve 3; a second separation area is formed between the first separation electrode sleeve 3 and the second separation electrode sleeve 2; because the distance between the central electrode 4 and the first separation electrode sleeve 3 is different from the distance between the first separation electrode sleeve 3 and the second separation electrode sleeve 2, ions with different mobility changes are allowed to enter a detection area through the separation area 1, and the simultaneous separation of different compounds is realized; and finally, the ions enter a detection area, and positive and negative ions respectively reach a detection electrode pair 6 and a detection electrode pair 7 under the action of bias voltage to be detected.
Claims (5)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711272311.3A CN109887822B (en) | 2017-12-06 | 2017-12-06 | Novel sleeve type ion migration tube |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711272311.3A CN109887822B (en) | 2017-12-06 | 2017-12-06 | Novel sleeve type ion migration tube |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109887822A CN109887822A (en) | 2019-06-14 |
| CN109887822B true CN109887822B (en) | 2020-04-07 |
Family
ID=66923272
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711272311.3A Active CN109887822B (en) | 2017-12-06 | 2017-12-06 | Novel sleeve type ion migration tube |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109887822B (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101752178A (en) * | 2008-12-17 | 2010-06-23 | 中国科学院大连化学物理研究所 | Cylindrical non-symmetric field ion migration tube |
| CN101752177A (en) * | 2008-12-17 | 2010-06-23 | 中国科学院大连化学物理研究所 | A Combined High-field Asymmetric Waveform Ion Transfer Tube |
| CN102414779A (en) * | 2009-05-01 | 2012-04-11 | 萨莫芬尼根有限责任公司 | Ion transfer tube and mass spectrometer system |
| CN102636555A (en) * | 2011-12-19 | 2012-08-15 | 中国科学院合肥物质科学研究院 | Miniature measurement and control system fit for high-field asymmetric waveform transference tube |
-
2017
- 2017-12-06 CN CN201711272311.3A patent/CN109887822B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101752178A (en) * | 2008-12-17 | 2010-06-23 | 中国科学院大连化学物理研究所 | Cylindrical non-symmetric field ion migration tube |
| CN101752177A (en) * | 2008-12-17 | 2010-06-23 | 中国科学院大连化学物理研究所 | A Combined High-field Asymmetric Waveform Ion Transfer Tube |
| CN102414779A (en) * | 2009-05-01 | 2012-04-11 | 萨莫芬尼根有限责任公司 | Ion transfer tube and mass spectrometer system |
| CN102636555A (en) * | 2011-12-19 | 2012-08-15 | 中国科学院合肥物质科学研究院 | Miniature measurement and control system fit for high-field asymmetric waveform transference tube |
Also Published As
| Publication number | Publication date |
|---|---|
| CN109887822A (en) | 2019-06-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0253155B1 (en) | Electric field control in ion mobility spectrometry | |
| US9068943B2 (en) | Chemical analysis using hyphenated low and high field ion mobility | |
| CN101752176B (en) | Array ion migration tube | |
| CN102103973B (en) | Bipolar ion migration tube | |
| US7397027B2 (en) | Multi-channel high-field asymmetric waveform ion mobility spectrometry | |
| US8866072B2 (en) | Method and apparatus for detecting and identifying gases by means of ion mobility spectrometry | |
| US8907275B1 (en) | Method and apparatus to improve the separation capacity in a sequence of ion filters incorporating at least two ion mobility analyzers | |
| CN105632874B (en) | A kind of direct current inhomogeneous field transference tube | |
| CN101752177B (en) | A Combined High-field Asymmetric Waveform Ion Transfer Tube | |
| US9310335B2 (en) | Dual polarity spark ion source | |
| EP3201616A1 (en) | Duel mode ion mobility spectrometer | |
| WO2006086880A1 (en) | Apparatus and method for forming a gas composition gradient between faims electrodes | |
| US20070278398A1 (en) | Ion mobility spectrometry waveform | |
| CN110828279B (en) | A two-dimensional separation ion transfer tube | |
| CN101752178B (en) | Cylindrical non-symmetric field ion migration tube | |
| CN109887822B (en) | Novel sleeve type ion migration tube | |
| CN102478545A (en) | Planar differential ion mobility spectrometer | |
| CN103163206A (en) | Composite ionization source difference type ion mobility spectrometry | |
| CN108091542A (en) | A kind of effectively ionized method of High-Field Asymmetric Waveform Ion Mobility Spectrometer sample | |
| CN110687192B (en) | A kind of trace compound measuring device and its measuring method | |
| CN103107060A (en) | Ionic migration spectrum with radio frequency confinement function | |
| CN110491766A (en) | A kind of direct current inhomogeneous field transference tube | |
| CN108091541B (en) | An Array Type High Field Asymmetric Waveform Ion Transfer Tube | |
| CN103776893A (en) | Ionic migration spectrometer of dielectric barrier discharging ionization source | |
| CN205175960U (en) | Measurement device for biomacromolecule charge -mass ratio |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |