CN109847103A - A kind of artificial blood vessel and preparation method thereof - Google Patents
A kind of artificial blood vessel and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to a kind of artificial blood vessel and preparation method thereof, the artificial blood vessel is hollow circular-tube structure, from inside to outside includes sequentially connected base, adhesive layer and bio-vitric layer, wherein the base is styreneisobutylene block copolymer.Preparation method includes injection molding, is cleaned and dried, and forms adhesive layer and bio-vitric layer etc..Artificial blood vessel prepared by the present invention is stabilized in human body, and operation suture property of putting up a bridge is good, is not easy to be formed thrombus, and tissue can receive rapidly and be compatible with to form tissue and fix, and tool has a broad prospect of the use.
Description
Technical field
The present invention relates to medicine and hygiene fields, especially a kind of artificial blood vessel and preparation method thereof.
Background technique
At the beginning of the development of artificial blood vessel (artificial blood vessel) starts from last century.When human body a part
When blood vessel cannot be guaranteed human normal blood supply due to artery sclerosis, embolism or breakage etc., blood vessel need to just be replaced, be taken
The surgical operations such as bridge or intervention are treated.It is to be transplanted using autologous vein, but its source is very limited, and is earliest
This, scientists begin one's study artificial blood vessel.
Scholars use tube made of the materials such as metal, glass, polyethylene, silicon rubber to carry out a large amount of animals first
Experiment, but Yin Qiyi in a short time concurrent intracavitary thrombus and fail to be widely applied clinically.Here simple to introduce at present
The artificial blood vessel material being often used: nineteen fifty-two, Voorhees is studied first to be made artificial blood vessel for polyvinyl and takes in animal experiments
Must succeed, and be used successfully to clinic in second year, this artificial blood vessel change previous artificial blood vessel tube wall without permeability.
Dacron-made artificial blood vessel is the vascular grafts used earliest, and since patency rate is higher, is successfully used for a long time
In big vascular replacement, but the manufacture requirement of small-caliber artificial blood vessel can not be fully met.Thereafter the Applications of Pure Silk Vascular Prosthesis developed by
It crimps and is not sufficiently stable in its screw type, easily cause blood vessel to inhale flat, and conformality is poor, strength is lower, and limit clinical application.
Expanded polytetrafluoroethylsealing artificial blood vessel has good biocompatibility and anticoagulant, but compliance is poor, transplanting
The patency rate of object is only 30%, and especially diameter is more obvious less than the ePTFE artificial blood vessel disadvantages mentioned above of 6mm, at a specified future date unobstructed
Rate is very poor.
Polyurethane PU artificial blood vessel material has more excellent biocompatibility, it is believed that using PU compared with ePTFE
The artificial blood vessel of material production can solve the above problem, therefore it is the direction that external many scholars study at present.PU has again
There are excellent fatigue durability, wearability, high resiliency and high intensity, therefore is widely used in field of biomedical materials.But so far
Until the present, existing PU material is not met by the high standard of artificial blood vessel clinical application.As found in the long-term use
PU will appear degradation with aging and calcification phenomenon in vivo, and material is cracked, or even all destroy.Change when carrying out modification to material
Property, when improving its histocompatbility, it can often be brought a negative impact again to the mechanical property even blood compatibility of material.
The artificial blood vessel material largely used at present is derived from the synthetic compounds such as polyester fiber, and tubing is harder, lacks true blood
Such retractility is managed, is easy to produce thrombus, therefore diameter cannot be below 6 millimeters.So there is the artificial blood vessel of natural silk.
Natural mulberry silk, this Applications of Pure Silk Vascular Prosthesis manufacture uses the silk through special processing, with unique knitting skill
Art is rolled into tubular, and protective layer, anti-Hemostatic Oral Liquid leakage, it may be said that be the best knot of silk and knitting skill are done with atypical silk in outside
It closes.Applications of Pure Silk Vascular Prosthesis diameter can accomplish 1 millimeter, be not easy to form thrombus, protein component can be compatible with in-vivo tissue, right
The immature patient for needing replacing blood vessel is also very useful.But its durability used is relatively short, increases when used for a long time more
The operation number and risk changed.
In original et al. Ke class medical material by it is most commonly used be polyurethanes.The machining property of polyurethane
It is good, bio-compatibility, but due to the fragment that the uncontrollable degradation of polyurethane in vivo is formed, constantly attract granulocyte, macrophage
Cell, leucocyte and foreign-body giant cell to implantation material at spread.It is broken to degrade by way of film forming package and phagocytosis fragment
Sheet material.To can around implantation material and surface formed obstruction, and have accelerate implant degradation potential danger.Similarly,
Silica type implantation material can degrade under the acidic environment of low ph value, and the material of polytetrafluoroethyl-ne alkenes can also face same problem.
Bio-vitric (Bioglass) is a kind of Na-Ca-Si system glass, after this kind of glass is implanted into human body, energy and biocycle
A series of special surface reactions occur for border, so that material and natural fabric is formed firm chemical bonds and have biology living
Property.In general Bioglass generation, refers to that group becomes the bioactivity glass of 45S5.Bio-vitric has become material science, bioid at present
Learn and molecular biology cross discipline, since bio-vitric has the characteristics that bioactivity, tissue engineering bracket material,
The application prospect of orthopaedics, dentistry, middle ear, treatment of cancer and pharmaceutical carrier etc. is considerable, mainly has:
1. application of the bio-vitric in dental treatment
Bio-vitric is applied to clinical repair bone, articular cartilage, skin and injury of blood vessel since 1985.Middle Ear Implant
Bone MEP is the earliest product of bioglass material, it can not only connect with soft tissue (ear-drum), but also can connect with bone, and clinical effectiveness is aobvious
Show and is relatively better than other biological ceramics and metal material.Second generation bioglass material ERMI can be used for filling up root of the tooth vacancy, avoid
Atrophy of the gum.ERMI is completely embedded with gum bone, has better curative effect compared with the other materials of prevention atrophy of the gum.The third generation is raw
Object glass material early production PerioGlas is mainly used for bone defect caused by periodontal disease and rebuilds and be locally filled with after having tooth pulled out.It is long
Phase clinical studies show, PerioGlas clinical effectiveness is good, has no adverse reaction to human body.Bio-vitric containing 50% phosphoric acid can
For treating hypersensitive dentin and incipient enamel caries tooth.The reason is that Bioglass with it due to being implanted at pulp chamber perforation
When contacting with blood and Level of Alveolar Bone tissue, complicated ion exchange can occur between moment and tissue, on bio-vitric surface
Silicon-rich gel layer is formed, and assembles and forms carbonated hydroxyapatite layer, quickly being formed and be deposited on punch block tooth by calcium-phosphate layer
In organizing in week, final calcification forms cementum and periodontal new attachment.The researchs such as Bakry contain the bio-vitric of 50% phosphoric acid, as a result
It shows that its biocompatibility is good, is a kind of safe biomaterial.
2. application of the bio-vitric in bone repair
After bio-vitric obtains good clinical effectiveness in dental disorder prevention and treatment, it is also applied to orthopaedics immediately,
Product has NovaBone (NovaBone).Bio-vitric mechanical strength is poor, is mainly used for non-weight bearing area bone defect healing.Due to
A series of chemical reaction can occur in the physiological environment of human body for bio-vitric surface, and can directly participate in body bone tissue
Metabolism and repair process, may finally form inorganic mineral constituents identical with human body on the surface of the material --- carbonic acid hydroxy-apatite
Stone)] CO, (2OH) (PO- [CaO-23-6410, and induce the growth of bone tissue, thus can be used for defect of human body bone filling and
It repairs.Ameri etc. is reported in adolescent idiopathic scoliosis patient's Posterolateral spine fusion orthopaedy and biological glass is respectively adopted
Glass and self crista iliaca bone collection, it is postoperative follwing-up in average 34.7 months (most 24 months short) discovery, bio-vitric group clinical effectiveness with
Self crista iliaca bone collection group is identical, and can reduce complication brought by self crista iliaca bone collection.Seddighi etc. is reported in neck
Using the titanium net of filling bio-vitric and autologous bone in vertebra disease anterior stabilization art, show within follwing-up in average 14.3 months, backbone melts
Conjunction rate is essentially identical compared with the titanium net for being only filled with autologous bone.
3. application of the bio-vitric in terms of pharmaceutical carrier
Drug therapy carrier is also one of most promising application of bio-vitric.Various drugs are stored in porous
In bio-vitric, it is then implanted into the related key position of human body, with the progress that bio-vitric surface is reacted, drug will discharge,
Reach purpose of curing the disease with a definite target in view, compared with traditional injecting method, has the advantages that uniform, treatment etc. is numerous for a long time, have
The curative effect of maximal efficiency.
4. application of the bio-vitric in Wound healing
It is also a current research direction that bioactivity glass, which is used to promote the healing of wound,.Some patents both domestic and external
This is related to.One kind is described in its patent if the D.C. Greenspan in the U.S. etc. to be cured for acceleration of wound and burn
The tissue substance of conjunction, wherein just including activity glass.The acceleration of bioactivity glass promotes the mechanism of Wound healing are as follows: when the material
In material implantation human body, under the action of body fluid, the big ion of Na, 2Ca isoreactivity dissolves out first, and the H in body fluid enters glass table
Face forms Si-OH, and then since Si-O-Si key destroys, random network is dissolved, and soluble silicon is released in the form of silanol, and
And a hydroxyapatite glued layer is formed on material fission surface rapidly.Soluble silicon has the metabolism of molecular level connective tissue
Effect and structure function, after bio-vitric dissolution, the raising of local Si concentrations can promote the cell interior phase of cell metabolism
Answer, excite the autocrine mediated response of factor for supporting wound healing, participate in all cells of wound repair factor for supporting wound healing from
Secretory reaction, participates in all cells tachyauxesis and division under the stimulation of factor for supporting wound healing of wound repair, and assembles
In the hydroxyapatite glued layer that material surface is formed, the entire surface of a wound of cambium is enable smoothly to climb shifting and covering.
Chinese invention patent application CN109009561A discloses a kind of artificial blood vessel and preparation method thereof, by blood vessel branch
Frame and inoculating cell are constituted, and the intravascular stent is successively by close-connected inner stent, middle layer bracket and outer stent structure
At the inner stent is one layer of porous fibre round tube shape structure being made of polyethylene glycol succinate and anti-coagulants；It is described
Middle layer bracket is one layer of porous fibre being made of Hydrogels material, bioceramic material (such as bio-vitric), growth factor
Round tube shape structure is tieed up, the inoculating cell is filled in adherency in the hole of the middle layer bracket；The outer stent is by poly- fourth
One layer of porous fibre round tube shape structure that succinate adipate is constituted.This blood vessel not can solve degradation and obstructing problem still.
Summary of the invention
The purpose of the invention is to overcome existing artificial blood vessel to degrade in human body, asking for a variety of adverse reactions is generated
Topic provides a kind of artificial blood vessel and preparation method thereof.Artificial blood vessel in the present invention utilizes chemical stability and biological stability
High tertiary carbon type copolymer comes manufacture of intraocular blood vessel, and the unique bio-vitric of integrated structure, to reach the Gao Sheng of this product
Object safety and high bio-compatibility form a kind of physical chemistry and stablize, and operation bridging suture property is good, are not easy to form thrombus, people
Body tissue can receive rapidly and be compatible with to form the fixed a kind of artificial blood vessel of tissue and the replacement production of other intracoelomic cavity pipe structures
Product.
The selection of base material is most important for artificial blood vessel.The main reason for causing artificial blood vessel application limited is people
The bio-compatibility of hematopoiesis tube material, ageing resistance must will be taken into account.It is raw in the material that current medical field is approved
The good material alternate item of object compatibility is relatively more, but the reliable material of anti-aging, anti-degradation in vivo fracture distress just not
It is easily found.This biology or chemical degradation are derived from the chain reaction of attack and the initiation of intracorporal free radical.Invention
People has chosen styreneisobutylene block copolymer (SIBS) according to the mechanism of production of free radical and the mechanism of polymer, knot
Structure formula is as follows.
A kind of copolymer of the SIBS as isobutene and styrene, tertiary carbon structure have natively blocked the shape of free radical
At, there is no the chemical bond that can be degraded: ehter bond (C-O-C) in polymer architecture, ester bond (O-CO-C), amide (N-CO-C),
Amino-acid ester (N-CO-O), urea bond (N-CO-N), carbonic ester (O-CO-O), singly-bound (C-C-C), double bond (C=C-C), thus just
Avoid the degradation of SIBS polymer in vivo, and subsequent internal stress reaction.After SIBS is implanted internal 2 years no matter
Sections observation and molecular weight under from microscope redeterminate, all without visible cracking and the phenomenon that molecular weight and molecular weight.Gather different
Butylene is free of any of above labile bond, it is preferred that it can prevent main chain oxygen every there are a dimethyl on a carbon
Change forms double bond.Many polyolefin such as polyethylene and polyacrylic propane, there are double bonds to lead to embrittlement on main polymer chain, low to scratch
Bent fatigue life and degradation.Polyisobutene is converted into elastomer and needs to be crosslinked with permanent crosslinking or fusible vacation.
In order to which material is processed into mouldable or extrudable medical device, polyisobutene central block will be integrated to by polystyrene
Amorphous (elasticity/rubber-like) polyisobutene segment is combined together by both ends, and the SIBS polymer of formation has just had both non-
The characteristics of degradation, plasticity.SIBS is applied to glaucoma shunts pipe at present and the vivo medicine-feeding carrier of taxol is demonstrate,proved
Make a clear distinction between right and wrong Chang Anquan, and inventor attempts SIBS material being applied to wider artificial blood vessel field for the first time.
As polystyrene block ratio 10-30 weight % in the styreneisobutylene block copolymer of base, not at this
A range will affect the rigidity of blood vessel, preferably 20 weight %.
Although SIBS have a variety of advantages, can not be compatible well with human body, for example, its can not be attached thereto
Human vas form stable connection, be also just unable to reach satisfied bridging effect.For this purpose, inventor has chosen bio-vitric
As intermediate medium, the blood vessel of implantation is ideally combined together safely with tissue.
Bio-vitric layer with a thickness of 50 μm~250 μm, position that thickness is used according to blood vessel and bioglass particles
Size determines.The selection of bioglass particles has 50 μm, 100 μm, 150 μm, 200 μm and 250 μm five kinds.Applicable range according to
It is adjusted in the region of human body implantation and the size of blood vessels caliber.
Concrete scheme is as follows:
A kind of artificial blood vessel, is hollow circular-tube structure, and the artificial blood vessel includes sequentially connected base, glues from inside to outside
Tie layer and bio-vitric layer, wherein the base is styreneisobutylene block copolymer.
Further, polystyrene block ratio 10-30 weight % in the base.
Further, the adhesive layer is SILASTIC adhesive Series silica gel adhesive, preferably DOW CORNING
SILASTIC。
Further, the bio-vitric layer is the thin layer that bioactivity glass 45S5 is formed, bioactivity glass 45S5
Particle diameter be 50-720 μm.
Further, the interior diameter of the base is 4mm-15mm, with a thickness of 0.5mm-2mm.
Further, the adhesive layer with a thickness of 50-100 μm.
The present invention also provides the preparation methods of the artificial blood vessel, comprising the following steps:
Step 1: styreneisobutylene block copolymer being molded into blood vessel, interior diameter at 180-240 DEG C using injection molding machine
For 4mm-15mm, with a thickness of 0.5mm-2mm；
Step 2: being dried after the blood vessel of injection molding in step 1 acetone, ethyl alcohol are successively cleaned；
Step 3: the vascular cuffing after will be dry in step 2 is equal to one end of the stainless steel bar of blood vessel interior diameter in diameter, no
The rust rod iron other end is fixed on Stirring head, and by the rotation of Stirring head, it is viscous to smear one layer of silica gel in blood vessel surface
Mixture forms adhesive layer；
Step 4: bio-vitric powder being laid in clean polytetrafluoroethyldisk disk, make the blood vessel containing adhesive layer in life
It is rolled in object glass powder, is uniformly adhered bio-vitric powder, and shake blood vessel to remove the loose insecured of surface
The bio-vitric powder of bonding；
Step 5: the blood vessel for coating bio-vitric powder is placed under room temperature dry 12-20 hours to get artificial blood vessel.
Further, the step 1 includes: that 1a selects single facade or double facade injection molding machines, first carries out styrene-isobutyl
The filling of alkene block copolymer, temperature are 180-240 DEG C, and filling is the first step during entire injection cycle, and the time is from mould
Tool closure starts injection molding and counts, until mold cavity is filled into 93-97 volume %；1b carries out pressure maintaining processing, is continuously applied pressure
Power 1000-2000psi is compacted melt, increases fusant density, to compensate the contraction of melt cooling stage；1c uses water cooling or sky
Air cooling after being demoulded after part cooling is cured to suitable rigid, is deformed due to by external force to avoid product, excellent
Select organosiloxane as release agent.
Further, the step 2 includes: that 2a immerses the blood vessel of injection molding in step 1 in acetone, guarantees tube wall
It is inside and outside to be totally immersed into acetone, it is stirred 20-40 seconds with glass bar, to remove the impurity being adhered in blood vessel surface in injection moulding process
And release agent；Blood vessel is taken out after 2b as in clean beaker, addition ethyl alcohol all to immerse in ethyl alcohol inside and outside tube wall, uses glass
Stick stirs 30 seconds, cleans blood vessel using ethyl alcohol；2c finally takes out the blood vessel cleaned as cleaning in glass dish, first at room temperature
Dry 0.5-1.5 hours, later in vacuum drying oven 38-42 DEG C it is 1-3 hours dry.
Further, in the step 3 Stirring head velocity of rotation be 15-20rpm, formed adhesive layer with a thickness of
50-100μm。
The utility model has the advantages that
Artificial blood vessel of the present invention, the excellent biology by the security feature of SIBS being chronically implanted, with bio-vitric
Performance combines, and is not only applicable to short-term implantable intravascular, is equally applicable to be chronically implanted.The artificial blood vessel guides artificial blood
The perienchyma of pipe assembles to vascular wall, and the normal microenvironment for forming class ontology just seems increasingly important.It both can be to avoid artificial
The formation in the gap among tube wall and musculature, avoids hydrops.Equally, mutually merging for guidance tissue and vascular wall can be with
The fixation to vascular wall is played, the effect of normal infiltration and tissue metabolism is maintained.
Moreover the preparation method of artificial blood vessel of the present invention, blood vessel base, interior diameter 4mm-is made using injection molding machine
15mm has stable structure and wide applicability with a thickness of 0.5mm -2mm.
Further, the preparation method of artificial blood vessel of the present invention is ingenious by stainless steel bar and Stirring head
It realizes the formation of adhesive layer and bio-vitric layer, there is operation convenience.
In short, artificial blood vessel prepared by the present invention is stabilized in human body, operation bridging suture property is good, is not easy to form blood
Bolt, tissue can receive rapidly and be compatible with to form tissue and fix, and tool has a broad prospect of the use.
Detailed description of the invention
In order to illustrate more clearly of technical solution of the present invention, attached drawing will be briefly described below, it should be apparent that,
The accompanying drawings in the following description merely relates to some embodiments of the present invention, rather than limitation of the present invention.
Fig. 1 is the artificial blood vessel cross section structure schematic diagram that one embodiment of the invention 1 provides.
Specific embodiment
The preferred embodiment of the present invention is described in more detail below.Although the following describe preferred implementations of the invention
Mode, however, it is to be appreciated that may be realized in various forms the present invention without that should be limited by the embodiments set forth herein.It is real
It applies and particular technique or condition person is not specified in example, according to the literature in the art described technology or conditions or according to product
Specification carries out.Reagents or instruments used without specified manufacturer, being can be with conventional products that are commercially available.Under
In the embodiment in face, such as it is not known and illustrates, " % " refers both to weight percent.
Main agents used below include:
SIBS 102T-FD: 10,000 dalton of molecular weight, polystyrene block ratio 20%.Other workable SIBS
Lot number are as follows: 062A, 062M, 062H, 062T, 072T, 073T, 102T, 103T, 103T-FD, 102T-FC, 103T-FC.Product is
Kaneka North America LLC produces.
Bio-vitric: 45S5Bioglass, applicable particle diameter range have: A, 50-300 μm；Or B, 300-500 μ
m；Or C, 500-720 μm.
Bonding agent: DOW CORNING SILASTIC, Medical Adhesive Silicone Type A.Homologous series can be used
SILASTIC adhesive, but DOW CORNING SILASTIC is best to the connection effect of SIBS and bio-vitric.
Embodiment 1
With reference to Fig. 1, artificial blood vessel is hollow circular-tube structure, from inside to outside by sequentially connected base 1, adhesive layer 2 and life
Object glassy layer 3 forms, wherein base 1 is styreneisobutylene block copolymer, polystyrene block ratio 20 weight %, interior
Diameter is 4mm, and with a thickness of 1.6mm, adhesive layer 2 is DOW CORNING SILASTIC thin layer, and with a thickness of 60 μm, bio-vitric layer 3 is
45S5Bioglass (particle diameter is 50-300 μm) is adsorbed on the thin layer of 2 surface of adhesive layer formation.
The artificial blood vessel is stabilized in human body, and operation bridging suture property is good, is not easy to form thrombus, and tissue can be rapidly
It receives and is compatible with to form tissue and fix, tool has a broad prospect of the use.
Embodiment 2
A kind of artificial blood vessel is hollow circular-tube structure, from inside to outside by sequentially connected base 1, adhesive layer 2 and biological glass
Glass layer 3 forms, wherein base 1 is styreneisobutylene block copolymer, 15 weight % of polystyrene block ratio, interior diameter
For 10mm, with a thickness of 1mm, adhesive layer 2 is DOW CORNING SILASTIC thin layer, and with a thickness of 70 μm, bio-vitric layer 3 is
45S5Bioglass (particle diameter is 300-500 μm) is adsorbed on the thin layer of 2 surface of adhesive layer formation.
Embodiment 3
A kind of artificial blood vessel is hollow circular-tube structure, from inside to outside by sequentially connected base 1, adhesive layer 2 and biological glass
Glass layer 3 forms, wherein base 1 is styreneisobutylene block copolymer, 25 weight % of polystyrene block ratio, interior diameter
For 12mm, with a thickness of 0.8mm, adhesive layer 2 is DOW CORNING SILASTIC thin layer, and with a thickness of 80 μm, bio-vitric layer 3 is
45S5Bioglass (particle diameter is 500-720 μm) is adsorbed on the thin layer of 2 surface of adhesive layer formation.
Embodiment 4
A kind of artificial blood vessel is hollow circular-tube structure, from inside to outside by sequentially connected base 1, adhesive layer 2 and biological glass
Glass layer 3 forms, wherein base 1 is styreneisobutylene block copolymer, 18 weight % of polystyrene block ratio, interior diameter
For 15mm, with a thickness of 0.5mm, adhesive layer 2 is DOW CORNING SILASTIC thin layer, and with a thickness of 100 μm, bio-vitric layer 3 is
45S5Bioglass (particle diameter is 50-300 μm) is adsorbed on the thin layer of 2 surface of adhesive layer formation.
Embodiment 5
A kind of artificial blood vessel is hollow circular-tube structure, from inside to outside by sequentially connected base 1, adhesive layer 2 and biological glass
Glass layer 3 forms, wherein base 1 is styreneisobutylene block copolymer, 20 weight % of polystyrene block ratio, interior diameter
For 8mm, with a thickness of 2mm, adhesive layer 2 is SILASTIC adhesive Series silica gel adhesive, with a thickness of 50 μm, bio-vitric
Layer 3 is the thin layer that 45S5Bioglass (particle diameter is 500-720 μm) is adsorbed on the formation of 2 surface of adhesive layer.
Embodiment 6
Artificial blood vessel is prepared, steps are as follows:
Step 1:SIBS injection molding.
Single facade or double facade injection molding machines are selected, according to the different selection injection temperatures of material, range is in 180-240
℃.Filling is the first step during entire injection cycle, and the time is molded since being closed mold and counts, and is filled to mold cavity
Until about 95 volume %.
Then pressure maintaining processing is carried out, continu to press is compacted melt, increases plastic density (density), to compensate plastics
Contraction, pressure: 1000-2000psi.
It is finally cooled down, in injection forming mold, the design of cooling system is extremely important.This is because moulding plastics
Product is only cooled and solidified to certain rigidity, is just avoided that plastic products are deformed due to by external force after demoulding.Cooling is excellent
Select water cooling or air two kinds cooling.Portioned product uses organosiloxane as release agent in knockout course.
Product parameters: interior diameter 4mm-15mm, blood vessel wall thickness is from 0.5mm-2mm.
Step 2: the SIBS blood vessel finished product of injection molding being immersed in acetone, guarantees that the inside and outside of tube wall is totally immersed into acetone
In, clean the ingredients such as impurity and the release agent that may be adhered in blood vessel surface in injection moulding process.It is stirred 30 seconds, is taken with glass bar
Blood vessel is as in clean beaker out.Ethyl alcohol is added all to immerse in ethyl alcohol inside and outside tube wall, cleans blood vessel using ethyl alcohol.Use glass
Stick stirs 30 seconds, takes out the blood vessel cleaned as in cleaning glass dish.The SIBS blood vessel cleaned is dried 1 hour at room temperature
Afterwards, 40 DEG C drying 2 hours in vacuum drying oven.Vacuum and heating drying compared to the advantage of direct drying is first drying at room temperature again
Heating time is reduced, the possibility of polymer thermal instability is avoided and saves the production energy.
Step 3: the vascular cuffing after will be dry in step 2 is equal to one end of the stainless steel bar of blood vessel interior diameter in diameter, no
The rust rod iron other end is fixed on Stirring head, by the rotation of Stirring head, at the slow-speed of revolution (15-20rpm), in blood
Pipe surface smears one layer of silica adhesive, adhesive layer is formed, with a thickness of 50-100 μm.
Step 4: bio-vitric powder being laid in clean polytetrafluoroethyldisk disk, make the blood vessel containing adhesive layer in life
It is rolled in object glass powder, is uniformly adhered bio-vitric powder, and shake blood vessel to remove the loose insecured of surface
The bio-vitric powder of bonding；
Step 5: the blood vessel for coating bio-vitric powder is placed under room temperature dry 12-20 hours to get artificial blood vessel.It reaches
To be completely dried be placed on it is spare in sterilization bag.
The preferred embodiment of the present invention has been described above in detail, still, during present invention is not limited to the embodiments described above
Detail within the scope of the technical concept of the present invention can be with various simple variants of the technical solution of the present invention are made, this
A little simple variants all belong to the scope of protection of the present invention.
It is further to note that specific technical features described in the above specific embodiments, in not lance
In the case where shield, it can be combined in any appropriate way.In order to avoid unnecessary repetition, the present invention to it is various can
No further explanation will be given for the combination of energy.
In addition, various embodiments of the present invention can be combined randomly, as long as it is without prejudice to originally
The thought of invention, it should also be regarded as the disclosure of the present invention.
Claims (10)
1. a kind of artificial blood vessel is hollow circular-tube structure, it is characterised in that: the artificial blood vessel includes being sequentially connected from inside to outside
Base, adhesive layer and bio-vitric layer, wherein the base be styreneisobutylene block copolymer.
2. artificial blood vessel according to claim 1, it is characterised in that: polystyrene block ratio 10-30 in the base
Weight %.
3. artificial blood vessel according to claim 1, it is characterised in that: the adhesive layer is SILASTIC adhesive system
Column silica adhesive, preferably DOW CORNING SILASTIC.
4. artificial blood vessel according to claim 1, it is characterised in that: the bio-vitric layer is bioactivity glass 45S5
The thin layer of formation, the particle diameter of bioactivity glass 45S5 are 50-720 μm.
5. artificial blood vessel described in any one of -4 according to claim 1, it is characterised in that: the interior diameter of the base is 4mm-
15mm, with a thickness of 0.5mm-2mm.
6. artificial blood vessel according to claim 5, it is characterised in that: the adhesive layer with a thickness of 50-100 μm.
7. the preparation method of artificial blood vessel of any of claims 1-6, comprising the following steps:
Step 1: styreneisobutylene block copolymer being molded into blood vessel at 180-240 DEG C using injection molding machine, interior diameter is
4mm-15mm, with a thickness of 0.5mm-2mm；
Step 2: being dried after the blood vessel of injection molding in step 1 acetone, ethyl alcohol are successively cleaned；
Step 3: the vascular cuffing after will be dry in step 2 is equal to one end of the stainless steel bar of blood vessel interior diameter, stainless steel in diameter
The stick other end is fixed on Stirring head, by the rotation of Stirring head, smears one layer of silica adhesive in blood vessel surface,
Form adhesive layer；
Step 4: bio-vitric powder being laid in clean polytetrafluoroethyldisk disk, make the blood vessel containing adhesive layer in biological glass
It is rolled in glass powder, is uniformly adhered bio-vitric powder, and shake loose non-strong bond of the blood vessel to remove surface
Bio-vitric powder；
Step 5: the blood vessel for coating bio-vitric powder is placed under room temperature dry 12-20 hours to get artificial blood vessel.
8. the preparation method of artificial blood vessel according to claim 7, it is characterised in that: the step 1 includes: that 1a selects list
Facade or double facade injection molding machines first carry out the filling of styreneisobutylene block copolymer, and temperature is 180-240 DEG C, filling
It is the first step during entire injection cycle, the time is molded since being closed mold and counts, and is filled into 93-97 to mold cavity
Until volume %；1b carries out pressure maintaining processing, and continu to press 1000-2000psi is compacted melt, increases fusant density, to mend
Repay the contraction of melt cooling stage；1c is cooling using water cooling or air, is demoulded after part cooling is cured to suitable rigid
Afterwards, it is deformed due to by external force to avoid product, preferably organosiloxane is as release agent.
9. the preparation method of artificial blood vessel according to claim 7, it is characterised in that: the step 2 includes: 2a by step
The blood vessel of injection molding in 1 immerses in acetone, guarantees that the inside and outside of tube wall is totally immersed into acetone, is stirred 20-40 seconds with glass bar,
To remove the impurity and release agent that are adhered in blood vessel surface in injection moulding process；Blood vessel is taken out after 2b as in clean beaker,
Ethyl alcohol is added all to immerse in ethyl alcohol inside and outside tube wall, is stirred 30 seconds with glass bar, cleans blood vessel using ethyl alcohol；2c finally takes out
The blood vessel cleaned is first 0.5-1.5 hours dry at room temperature as cleaning in glass dish, later the 38-42 in vacuum drying oven
DEG C dry 1-3 hours.
10. the preparation method of artificial blood vessel according to claim 7, it is characterised in that: Stirring head in the step 3
Velocity of rotation be 15-20rpm, formed adhesive layer with a thickness of 50-100 μm.
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