CN109833562B - A disposable self-destructing vibrating head assembly and a penetration promoting instrument using the assembly - Google Patents

Abstract

The invention discloses a disposable self-destruction vibrating head assembly and a permeation promoting instrument using the same, comprising a hollow pressure-bearing member, wherein an inner core is arranged in the hollow of the pressure-bearing member, and the inner core is connected with the pressure-bearing member through at least 1 twisting-off members; the inner core comprises a working section and a connecting section, wherein the upper surface of the working section is provided with a micro device used for penetrating only the stratum corneum of the skin, and the circumferential direction of the connecting section is provided with an annular clamping groove; still include the connecting piece, the upper end of connecting piece be equipped with annular draw-in groove matched with buckle, the lower extreme is equipped with the platform. The disposable self-destruction type vibrating head assembly and the permeation promoting instrument using the same achieve the self-destruction effect through the rotation breaking of the pressure bearing piece and the inner core, avoid the problem of repeated use, ensure the absorption efficiency of human skin and ensure the personal health of a user.

Description

A disposable self-destructible vibrating head assembly and a permeation-promoting instrument using the assembly

Technical field

The present invention relates to the technical field of transcutaneous delivery devices, and in particular, to a disposable self-destructing vibrating head assembly and a permeation-promoting instrument using the assembly.

Background technique

Currently, nanoneedles and nanochips are used in the medical or beauty industries. Take the beauty industry as an example. Human skin has epidermis and dermis. When applying beauty products to the human body, beauty products must pass through the epidermis and enter the dermis before they can be absorbed by the human body. However, due to the blocking effect of the epidermis, the absorption efficiency of beauty products is limited. Nano-microneedle is a kind of microneedle that uses nanotechnology to open skin ducts. The needle is like a small chip square, which is covered with dense, invisible needles. Press this small square on the skin , can allow beauty products to enter the epidermis, and people will hardly feel it. Nanochip is a special nano-penetration-promoting tool developed based on the structure of human skin. It is carved from single crystal silicon through nanotechnology technology. The surface of the nanochip is a series of microneedle arrays, which can open the outermost stratum corneum of the skin without damaging the dermis, greatly improving the penetration ability of the delivery medium on the skin epidermis. The biocompatibility of single crystal silicon also ensures the safety of nanocrystals during use.

Therefore, the epidermis of human skin can be pierced through nano-microneedles or nano-chips to open skin channels. In this way, because it does not act on the dermis, it will not cause trauma to the human body and improves the absorption efficiency of the skin. In order to achieve the above purpose, nano-microneedles or nano-chips can be placed on a platform of a plastic component, and the nano-micro-needles or nano-chips can be used to act on human skin. Taking into account the issues of hygiene and safety and preventing cross-infection, such products require users to use them once. However, in market behavior, reuse driven by profit frequently occurs. This kind of reuse can easily lead to users losing beauty. Disease transmission and bacterial infection during the process.

Contents of the invention

In view of the above-mentioned shortcomings in the prior art, the purpose of the present invention is to provide a disposable self-destructing vibrating head assembly and a permeation-promoting instrument using the assembly.

In order to achieve the above objects, the present invention adopts the following technical solutions:

A disposable self-destructing vibrating head assembly, including a hollow pressure-bearing part. The hollow interior of the pressure-bearing part is provided with an inner core. The inner core and the pressure-bearing part are connected by at least one twist-off. The inner core includes a working section and a connecting section, the upper surface of the working section is provided with a micro-device for penetrating only the stratum corneum of the skin, and an annular slot is provided on the circumference of the connecting section; it also includes a connecting section The upper end of the connecting piece is provided with a buckle that matches the annular slot, and the lower end is provided with a platform.

Further, the inner surface of the pressure-bearing member is provided with protrusions.

Further, the inner core and the pressure-bearing member are connected through four twisting members.

Further, the cross-sections of the pressure-bearing member and the working section of the inner core are both circular.

Further, the cross section of the connecting section of the inner core is triangular or square, and the buckle at the upper end of the connecting piece is a three-lobed buckle or a four-lobed buckle that matches the connecting section. buckle.

Further, the micro device is a nano-microneedle or a nano-wafer.

Further, the lower end of the connecting piece is provided with a connecting slot, and the platform is provided with a platform buckle. The connecting piece and the platform are locked and connected through the connecting slot and the platform buckle.

A penetration promoting instrument, including the above-mentioned disposable self-destructing vibrating head assembly, an upper shell detachably connected to the disposable self-destructing vibrating head assembly, and a lower shell detachably connected to the upper shell body; the lower shell is fixed on the base, a power component is provided in the base and the lower shell, and a motor is electrically connected to the power component, one end of a shaft is drivingly connected to the motor, and the other is One end is against the platform of the disposable self-destructing vibrating head assembly; a limiting piece is provided in the upper housing, the connecting piece is inserted into the limiting piece, and the platform cannot pass through the limiting piece. As for the limiting member, a limiting spring is provided between the platform and the limiting member.

Further, the power supply assembly includes a power supply body, a circuit board connected to the power supply body, and a switch electrically connected to the circuit board; the motor is electrically connected to the circuit board.

Further, the power supply body is a rechargeable power supply, and the circuit board is electrically connected to a charging port.

Further, the base is provided with a switch hole and a charging port hole corresponding to the switch and the charging port.

Further, the upper port portion of the upper housing is provided with an upper slot that matches the bumps, and the upper housing is connected with the disposable through the upper slot and the bumps. The self-destructive vibrating head assembly is detachably connected; the upper end of the lower housing is provided with a bump, and the lower end of the upper case is provided with a lower slot that matches the bump, and the The upper shell is detachably connected to the lower shell through the engagement of the lower slot and the bump; the upper port of the base is provided with a base bump, and the lower port of the lower shell is A base slot is provided that matches the base bump, and the lower housing is detachably connected to the base through the engagement of the base slot and the base bump.

Furthermore, a sealing member is provided between the motor and the platform, and a through hole for passing the shaft is provided in the sealing member.

The outstanding effects of the present invention are: the disposable self-destructing vibrating head assembly of the present invention and the permeability promoter using the assembly achieve the self-destructing effect by turning off the pressure-bearing parts and the inner core, thus avoiding the problem of reuse , while ensuring that human skin improves absorption efficiency, it also protects the user's personal health.

Description of the drawings

Figure 1 is a schematic diagram of the pressure-bearing part and inner core structure of Embodiment 1 of the present invention;

Figure 2 is a schematic structural diagram of the connector according to Embodiment 1 of the present invention;

Figure 3 is a schematic structural diagram of the platform according to Embodiment 1 of the present invention;

Figure 4 is an exploded view of the structure of Embodiment 2 of the present invention;

Figure 5 is a bottom view of the upper housing according to Embodiment 2 of the present invention;

Figure 6 is a schematic structural diagram of Embodiment 2 of the present invention;

Figure 7 is a graph showing changes in permeability over time in experimental examples of the present invention.

Detailed ways

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some of the embodiments of the present invention, rather than all the embodiments.

Example 1

As shown in Figures 1-3, a disposable self-destructive vibrating head assembly in this embodiment includes a hollow pressure-bearing part 1, and the inner surface of the pressure-bearing part 1 is provided with protrusions 11.

The hollow interior of the pressure-bearing part 1 is provided with an inner core 2. The inner core 2 and the pressure-bearing part 1 are connected by four twisting parts 3; the inner core 2 includes a working section 21 and a connecting section 22. The upper surface of the working section 21 A micro device 23 is provided for penetrating only the stratum corneum of the skin, and the micro device 23 is a nanochip.

An annular slot 24 is provided in the circumferential direction of the connecting section 22; the cross-sections of the pressure-bearing member 1 and the working section 21 of the inner core 2 are both circular.

It also includes a connecting piece 4. The upper end of the connecting piece 4 is provided with a buckle 41 that matches the annular slot 24, and the lower end is provided with a platform 42. The connecting section 22 of the inner core 2 has a square cross-section, and the buckle 41 on the upper end of the connecting piece 4 is a four-petal buckle that matches the connecting section 22 . The lower end of the connector 4 is provided with a connection slot 43, and the platform 42 is provided with a platform buckle 44. The connector 4 and the platform 42 are locked and connected through the connection slot 43 and the platform buckle 44.

Example 2

This embodiment is similar to Embodiment 1, except that optionally, the cross section of the connecting section 22 of the inner core 2 is triangular, and the buckle 41 at the upper end of the connecting piece 4 is a three-lobed type that matches the connecting section 22. Snap; the micro device 23 is a nano-microneedle.

Example 3

A permeability-promoting instrument of this embodiment includes the disposable self-destructing vibrating head assembly of Embodiment 1, an upper housing 5 detachably connected to the disposable self-destructing vibrating head assembly, and an upper housing 5 removably connected to the disposable self-destructing vibrating head assembly. The lower housing 6 is connected; the lower housing 6 is fixed on the base 7. The base 7 and the lower housing 6 are provided with a power supply component and a motor 8 electrically connected to the power supply component. One end of a shaft 9 is driven by the motor 8 The other end is connected to the platform 42 of the disposable self-destructing vibration head assembly; the upper housing 5 is equipped with a limiter 51, the connector 4 is inserted into the limiter 51, and the platform 42 cannot pass through the limiter 51. 51. A limiting spring 52 is provided between the platform 42 and the limiting member 51.

The power supply assembly includes a power supply body 61, a circuit board 62 connected to the power supply body 61, and a switch 63 electrically connected to the circuit board 62; the motor 8 is electrically connected to the circuit board 62.

The power supply body 61 is a rechargeable power supply, and the circuit board 62 is connected to a charging port 64 .

The base 7 is provided with a switch hole 71 and a charging port hole 72 corresponding to the switch 63 and the charging port 64 .

The upper end of the upper housing 5 is provided with an upper slot 53 that matches the bump 11. The upper housing 5 can be detachably connected to the disposable self-destructing vibrating head assembly through the engagement of the upper slot 53 and the bump 11. Connection; the upper port of the lower housing 6 is provided with a bump 65, and the lower port of the upper housing 5 is provided with a lower slot 54 that matches the bump 65. The upper shell 5 passes through the lower slot 54 and the bump. 65 is detachably connected to the lower housing 6; the upper end of the base 7 is provided with a base bump 73, and the lower end of the lower case 6 is provided with a base slot 66 that matches the base bump 73. The lower housing 6 is detachably connected to the base 7 through the engagement of the base slot 66 and the base protrusion 73 .

A seal 10 is provided between the motor 8 and the platform 42. The seal 10 is provided with a through hole 101 for passing the shaft 9.

In this embodiment, a disposable self-destructing vibrating head assembly and a permeation promoter using the assembly achieve a self-destructing effect by turning off the pressure-bearing part 1 and the inner core 2, thereby avoiding the problem of reuse and ensuring that the human body is protected. While improving the absorption efficiency of the skin, it also protects the user's personal health.

Experimental example

This experiment compares the penetration promotion of self-prepared lidocaine gel using the disposable self-destructing vibrating head assembly of the present invention (the micro device uses nanochips) in conjunction with the penetration promoting instrument (Group A) and directly setting the nanochips on the shaft. The transdermal absorption results after 20 seconds were processed by the instrument (Group B) respectively.

The experimental method is as follows:

Take a pig ear from the refrigerator, remove the skin to a thickness of 800 μm, and remove the hair on the surface until it is smooth. After soaking in PBS (7.4) for 10 to 15 minutes, take 2 portions and cut them into the size of the outer edge of the receiving pool. Group A and Group B are incubated for 20 seconds and placed between the receiving pool and the administration pool. PBS (7.4) at 37±0.2℃ Equilibrate for 1 hour. Use Franze diffusion cell, the dosage is 120mg, the receiving cell volume is 2.5mL, the actual transdermal area is 0.66cm ² , the receiving liquid is PBS (7.4), the temperature is 37±0.2℃, and the magnetic stirring is 280rmp.

As can be seen from Figure 7 (where ◆ is group A and ■ is group B), compared with group A, the lidocaine gel in group B has poorer transdermal effect, while the lidocaine gel in group A has better transdermal The effect is significantly improved. The most unexpected thing is that although they all use nanochips, the effect of group A is significantly better than that of group B, indicating that the present invention can significantly improve the penetration-promoting effect of nanochips and has advantages in application.

The above are only preferred specific embodiments of the present invention, but the protection scope of the present invention is not limited thereto. Any person familiar with the technical field can, within the technical scope disclosed in the present invention, implement the technical solutions of the present invention. Equivalent substitutions or changes of the inventive concept thereof shall be included in the protection scope of the present invention.

Claims (13)

1. A disposable self-destructive vibrating head assembly, characterized in that: the pressure-bearing device comprises a hollow pressure-bearing member, wherein an inner core is arranged in the hollow interior of the pressure-bearing member, and the inner core is connected with the pressure-bearing member through at least 1 twisting-off members; the inner core comprises a working section and a connecting section, wherein the upper surface of the working section is provided with a micro device used for penetrating only the stratum corneum of the skin, and the circumferential direction of the connecting section is provided with an annular clamping groove; still include the connecting piece, the upper end of connecting piece be equipped with annular draw-in groove matched with buckle, the lower extreme is equipped with the platform.

2. A disposable self-destructing vibrating head assembly according to claim 1 and characterized in that: and protruding points are arranged on the inner surface of the pressure-bearing piece.

3. A disposable self-destructing vibrating head assembly according to claim 1 and characterized in that: the inner core is connected with the pressure-bearing piece through 4 twisting-off pieces.

4. A disposable self-destructing vibrating head assembly according to claim 1 and characterized in that: the cross sections of the pressure bearing piece and the working section of the inner core are circular.

5. A disposable self-destructing vibrating head assembly according to claim 1 and characterized in that: the cross section of the connecting section of the inner core is triangular or square, and the buckle at the upper end of the connecting piece is a three-piece buckle or a four-piece buckle matched with the connecting section.

6. A disposable self-destructing vibrating head assembly according to claim 1 and characterized in that: the micro device is a nano-microneedle or a nano-wafer.

7. A disposable self-destructing vibrating head assembly according to claim 1 and characterized in that: the lower extreme of connecting piece is equipped with the connection draw-in groove, be equipped with the platform buckle on the platform, the connecting piece with the platform is through the connection draw-in groove with the locking of platform buckle is connected.

8. A permeation enhancer, which is characterized in that: comprising the disposable self-destructing vibratory head assembly of any one of claims 1-7, an upper housing removably connected to the disposable self-destructing vibratory head assembly, and a lower housing removably connected to the upper housing; the lower shell is fixed on a base, a power supply assembly and a motor are arranged in the base and the lower shell, the motor is electrically connected with the power supply assembly, one end of a shaft rod is in driving connection with the motor, and the other end of the shaft rod is propped against the platform of the disposable self-destruction vibrating head assembly; the upper shell is internally provided with a limiting part, the connecting part penetrates through the limiting part, the platform cannot penetrate through the limiting part, and a limiting spring is arranged between the platform and the limiting part.

9. A permeation enhancer according to claim 8, wherein: the power supply assembly comprises a power supply body, a circuit board connected with the power supply body and a switch electrically connected with the circuit board; the motor is electrically connected with the circuit board.

10. A permeation enhancer according to claim 9, wherein: the power supply body is a chargeable power supply, and the circuit board is electrically connected with a charging port.

11. A permeation enhancer according to claim 10, wherein: the base is provided with a switch hole and a charging hole corresponding to the switch and the charging hole.

12. A permeation enhancer according to claim 8, wherein: an upper clamping groove matched with the convex point is formed in the upper port part of the upper shell, and the upper shell is detachably connected with the disposable self-destruction vibrating head assembly through the clamping connection of the upper clamping groove and the convex point; the upper port part of the lower shell is provided with a protruding block, the lower port part of the upper shell is provided with a lower clamping groove matched with the protruding block, and the upper shell is detachably connected with the lower shell through the clamping connection of the lower clamping groove and the protruding block; the upper port portion of base is equipped with the base lug, the lower port portion of lower casing be equipped with base lug matched with base draw-in groove, the lower casing pass through the base draw-in groove with the joint of base lug with base detachably connects.

13. A permeation enhancer according to claim 8, wherein: and a sealing element is arranged between the motor and the platform, and a through hole for penetrating the shaft lever is formed in the sealing element.