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CN109795857A - Isolator bacteria collection operation transmission system - Google Patents

Isolator bacteria collection operation transmission system Download PDF

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Publication number
CN109795857A
CN109795857A CN201910121369.0A CN201910121369A CN109795857A CN 109795857 A CN109795857 A CN 109795857A CN 201910121369 A CN201910121369 A CN 201910121369A CN 109795857 A CN109795857 A CN 109795857A
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CN
China
Prior art keywords
pallet
transmission unit
cabin
isolator
sterilizing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201910121369.0A
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Chinese (zh)
Inventor
陈祥献
刘丹丹
黄海
宋荣军
陈�峰
刘维波
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Zhejiang University ZJU
Original Assignee
Zhejiang University ZJU
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zhejiang University ZJU filed Critical Zhejiang University ZJU
Priority to CN201910121369.0A priority Critical patent/CN109795857A/en
Publication of CN109795857A publication Critical patent/CN109795857A/en
Pending legal-status Critical Current

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Abstract

The present invention relates to automatic transmission systems, disclose a kind of isolator collection bacterium operation transmission system, comprising: sterilizing transmission unit, setting is in sterilizing cabin, for having the sterilizing stopper of stop of the control pallet in sterilizing cabin for tray transport to operational window;Operation transmission unit is arranged in operational window, for having tray transport to the cabin that discharges the operation stopper of stop of the control pallet in operational window, also having the precise positioning device for carrying out precise positioning to pallet;Discharge transmission unit, and setting, for discharging, has the discharging stopper of stop of the control pallet in discharging cabin in discharging cabin;Control unit issues the operation of instruction control sterilizing transmission unit, operation transmission unit and the transmission unit that discharges;Sterilizing, successively gap is docked for transmission unit, operation transmission unit and discharging transmission unit, using speed chain haulage.Smoothly transmitting between each cabin of isolator across cabin may be implemented in isolator collection bacterium operation transmission system of the invention.

Description

Isolator collection bacterium operation transmission system
Technical field
The present invention relates to automatic transmission system more particularly to a kind of isolator collection bacterium operation transmission systems.
Background technique
Since medical treatment collection bacterium needs to carry out in sterilized environment, it is therefore desirable to be operated in isolator.Isolator packet Sterilizing cabin, operational window and discharging cabin are included, is separated between each cabin by the way that hatch door is isolated.Sterilizing cabin is for collecting going out for bacterium container Bacterium, operational window are completed by manipulator for collecting bacterium operation, collection bacterium operation, are discharged after the completion of collection bacterium operation from discharging cabin.
Existing isolator collection bacterium operation transmission system is operated using manually-operated form: will bacterium reagent be collected Bottle is placed in the small handcart in sterilizing cabin, is pulled to collection bacterium operational window by manually holding in the palm, and the artificial hand of cabin is operated by isolator Set carries out cutting the operation such as bottle, filling, oscillation, then is placed in operation cabin small handcart, is pushed into discharging cabin by artificial gloves, moves out Cabin, entire transmission process need complete artificial participation.
Since each cabin of isolator needs hydrogen peroxide sterilization, manual intervention must be operated by rubber gloves, and Hydrogen peroxide gas is toxic, and to protect personal safety, the operation visual field is bad, and collection bacterium process consistency is not high.And for the ease of hand Set operation, sample size is limited, and each hatch door opens the door every time to bring outside air into isolator, needs to sterilize again.Due to relating to And toxic gas, it is unfavorable for the health of worker.
Assembly line automatic transmission system can automatically deliver product, save a large amount of manpower and material resources.Assembly line refers to certain Route on successively conveying articles handling machinery.Assembly line generally comprises traction piece, bearing carrier, driving device, opens Tight device, change course device and supporting member etc..
Common assembly line can be divided into following several: (1) plate chain type assembly line can be carried than heavier product, with carrier bar The steady conveying of product may be implemented as carrying in face.(2) product type of drum-type assembly line, carrying is extensive, is restricted It is few, it is used cooperatively with stopper, the continuous of product, the function of beat operation and accumulate may be implemented.(3) belt-type flowing water The product of line, carrying is lighter, and shape limitation is few, using belt as carrier and conveying, the steady conveying of product may be implemented, make an uproar Sound is small, and the conveying of light-duty material or product relatively long distance may be implemented.(4) Multiple chain flow line, using speed chain haulage, tooling Plate can be transmitted freely, make workpiece free movement or stopping using stopper positioning, workpiece can be traversing with automatic lifting at both ends Transition.
But it is sealed off between the sterilizing cabin of isolator, operational window and discharging three, cabin cabin by hermatic door, plate chain Formula assembly line, drum-type assembly line and belt-type assembly line are all difficult to the transport that links up between each cabin.
The coherent transport between each cabin of isolator may be implemented in Multiple chain flow line, but how to realize precise positioning It is an important technical problem of Multiple chain flow line.
Summary of the invention
The present invention provides a kind of isolator collection bacterium operation transmission system, may be implemented between each cabin of isolator across It smoothly transmits in cabin.
Specific technical solution is as follows:
A kind of isolator collection bacterium operation transmission system, comprising:
Sterilize transmission unit, and setting is in sterilizing cabin, for by tray transport to operational window, there is control pallet to sterilize The sterilizing stopper of stop in cabin;
Operation transmission unit is arranged in operational window, for by tray transport to the cabin that discharges, there is control pallet to operate The operation stopper of stop in cabin also has the precise positioning device that precise positioning is carried out to pallet;
Discharge transmission unit, and setting, for discharging, has going out for stop of the control pallet in discharging cabin in discharging cabin Expect stopper;
Control unit issues the operation of instruction control sterilizing transmission unit, operation transmission unit and the transmission unit that discharges;
Successively gap is docked for the sterilizing transmission unit, operation transmission unit and discharging transmission unit, is led using double-speed chain Draw.
The gap docking refers to gap setting between adjacent transmission cell, but transmission rail is corresponding, Ke Yishi Existing pallet is between adjacent transmission cell smoothly across transmission.Gap between adjacent transmission cell should be able to make to seal between cabin Door passes through.
Isolator includes sterilizing cabin, operational window and discharging cabin, is come between each cabin by hermatic door sealed separation.It goes out Bacterium cabin is used to collect the sterilizing of bacterium container, and operational window is completed for collecting bacterium operation, collection bacterium operation by manipulator, and collection bacterium operation is completed It discharges afterwards from discharging cabin.
The operational process of entire isolator collection bacterium operation transmission system is as follows: will manually fill collection bacterium container pallet put to It sterilizes on transmission unit, closes hatch door, pallet is sterilized stopper blocking, sterilizes in sterilizing cabin, disinfecting action is completed Afterwards, control unit opens the hermatic door between sterilizing cabin and operational window, and sterilizing stopper decline passes through pallet, and pallet is crossed over close Closure door enters on the operation transmission unit in operational window, and the stopper that sterilizes at this time resets, and hermatic door is closed;Pallet is in operation transmission It runs on unit, is blocked after encountering operation stopper, operation is collecting bacteria in the manipulator in control unit control operational window, collects After the completion of bacterium operation, the hermatic door between operational window and discharging cabin is opened, and operation stopper decline passes through pallet, and pallet is crossed over Hermatic door enters on the discharging transmission unit in discharging cabin, and hermatic door is closed at this time;Pallet is blocked after encountering discharging stopper, Control unit issues report information and the door out of my cabin that will discharge is opened, convenient for manually taking out pallet.
Preferably, the two sides of the sterilizing transmission unit, operation transmission unit and the transmission unit that discharges are provided with side block Plate, for preventing pallet during the motion to transmission unit two sides deflection.
It is further preferred that being provided with idler wheel on pallet two sides.On the one hand the setting of two side wheel of pallet can prevent Gap is excessive between pallet and side baffle, causes tray motion unstable, and another side can be by the cunning between pallet and side baffle Dynamic friction is converted into rolling friction, reduces the frictional force between pallet and side baffle.
Preferably, at the docking of adjacent transmission cell, side baffle extends outward to form across cabin guide plate.
In order to ensure pallet smoothly across cabin movement between each cabin, each intracorporal transmission unit in cabin is held in the mouth in adjacent cabin Place is met, side baffle extends outward to form across cabin guide plate, guides pallet smoothly across cabin movement.
For the collection bacterium efficiency for increasing entire isolator, several pallets are stacked with transport every time, it is possible to reduce each cabin The switch gate number of door.Operation is collecting bacteria in this again after just needing to be split the pallet being stacked in operational window, collection Pallet is stacked again after the completion of bacterium operation.
Preferably, the feed end of the operation transmission unit and discharge end are respectively arranged with tray separator structure and pallet heap Folded mechanism, carries out pallet fractionation and stackable pallet according to the control instruction of described control unit respectively.
The feed end of the operation transmission unit refers to operation transmission unit close to the one end in sterilizing cabin, and the operation passes The discharge end of defeated unit refers to operation transmission unit close to the one end in discharging cabin.
The tray separator structure is identical as the structure of stackable pallet mechanism, is controlled by described control unit, comprising:
Lifting platform, positioned at the lower section of pallet running track, for going up and down the pallet being stacked with;
Elevating mechanism, for driving the lifting of lifting platform;
Support refers to, for holding up the pallet on lifting platform above bottom tray;
Support refers to cylinder, flexible for driving support to refer to.
It is respectively arranged at the tray separator structure and at stackable pallet mechanism and splits stopper and stack stopper, point The top that pallet rests on the lifting platform of tray separator structure or stackable pallet mechanism Yong Yu not controlled.
It is blocked stop when the pallet being stacked with, which encounters, splits stopper, under the control instruction of control unit, is risen Descending mechanism drives lifting platform to rise, and lifting platform holds up the pallet above it, and support refers to that cylinder driving support refers to stretching, holds up bottom tray The pallet of top, lifting platform drives bottom tray decline later, splits stopper decline and bottom tray is allowed to pass through;Lifting platform later Rise, support refers to reset, and for pallet by lifting platform support, the height butt that lifting platform declines a pallet refers to that stretching holds up upper layer support Disk, on lifting platform lower tray year lifting platform decline, split stopper decline and lower tray allowed to pass through;It is repeated in later, Complete the fractionation of pallet.
Pallet is run at manipulator after splitting, and operation is collecting bacteria by manipulator.After the completion of collecting bacterium operation, when pallet is met To stop is blocked when stacking stopper, under the control instruction of control unit, lifting platform holds up its upper fray, and support refers to cylinder Driving support refers to stretching, holds up the pallet, and lifting platform declines later, and when the second pallet is blocked device blocking, lifting platform holds up second Pallet rises, and support refers to reset, and upper tray is stacked on the second pallet, and lifting platform rises the height of a pallet again, and support, which refers to, stretches It holds up, is repeated in later out, until completing the stacking of pallet.
After the completion of stacking, hermatic door is opened, and stacks stopper decline, and the pallet being stacked with enters discharging across hermatic door Cabin is stopped by discharging stopper, stacks stopper later and resets, hermatic door closing.
It is more stably stacked between pallet to realize, it is preferred that be provided at least four on the tray upper surface Support rod;At least four location holes matched with the support rod are provided on pallet lower surface.
Described matching refers to that the support rod of lower tray can be inserted into the location hole of upper tray bottom.When needing heap When folded, the they sup-port of lower tray is located in the location hole of upper tray, realizes that stablizing for pallet stacks.
It is further preferred that the supporting bar top has positioning chamfering.In bar insertion location hole easy to support.
Preferably, the precise positioning device is precise positioning pin, and pallet opposite position is provided with precisely to be determined with described The precise positioning hole that position pin matches.The precise positioning structure can realize the repetitive positioning accuracy of 0.04mm, convenient in operational window Body carries out accurate operation.
Preferably, tray bottom is provided with support plate.Convenient for reinforced tray intensity, deforms and cause after preventing pallet load-bearing Positioning is inaccurate.
Preferably, tray bottom is provided with notch, and the photoelectric sensing for identifying the notch is provided in Transmission system Device.The automatic identification of pallet type can be achieved.
Compared with prior art, the invention has the benefit that
Smooth across the cabin biography between each cabin of isolator may be implemented in isolator collection bacterium operation transmission system of the invention It is defeated, and registration;Entire transmission process can realize full-automation, participate in without artificial, efficiency of transmission is high.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of isolator and isolator collection bacterium operation transmission unit;
Fig. 2 is the structural schematic diagram of sterilizing transmission unit;
Fig. 3 is the structural schematic diagram of operation transmission unit;
Fig. 4 is tray structure diagram;
Fig. 5 is pallet bottom structure schematic diagram.
Specific embodiment
Present invention is further described in detail with reference to the accompanying drawings and examples, it should be pointed out that reality as described below It applies example to be intended to convenient for the understanding of the present invention, and does not play any restriction effect to it.
As shown in Figure 1, isolator is divided into three independent tanks thus since medical treatment collection bacterium needs to operate in sterilized environment Body: sterilizing cabin 1, operational window 2, discharging cabin 3.To prevent gas leakage, the first sealing is provided between operational window in sterilizing cabin Door, is provided with the second hermatic door between operational window and discharging cabin, and sterilizing cabin and discharging cabin are also respectively provided with sterilizing door out of my cabin With the door out of my cabin that discharges.
To prevent gas leakage, isolator collection bacterium operation transmission system is divided into three sections: sterilizing transmission unit 11, operation transmission Unit 21, discharging transmission unit 31 are separately positioned on sterilizing cabin 1, operational window 2, discharge in cabin 3, be mutually butted between adjacent segment, Spacing guarantees that pallet will not be unbalance in gap location center of gravity, which passes through for hermatic door depending on the length of pallet.
Three sections of Transmission systems use double-speed chain transmission mechanism, and the load-bearing of double-speed chain transmission mechanism is high, and meet market-oriented cost It is required that.
As shown in Fig. 2, every section of Transmission system includes that 111, two Horizontal load-bearings of motor are led by taking the transmission unit 11 that sterilizes as an example 112, two, the rail sprocket wheel 114 of sprocket wheel shaft 113, four and two groups of High speed chains 115 form.Two Horizontal load-bearing guide rails 112 It is arranged in parallel, two sprocket wheel shafts 113 are respectively drive sprocket shaft and by movable sprocket shaft, are rotatably connected on two water respectively The both ends of flat load-bearing guide rail.The drive shaft of motor 111 is mutually fixed with drive sprocket shaft, and four sprocket wheels 114 are respectively symmetrically solid Dingan County is mounted in the junction of two sprocket wheel shafts 113 and two 112 insides of Horizontal load-bearing guide rail.High speed chain 115 is by several Big rolling, several small rollings, several carrier bars composition, with small roll sleeve in carrier bar connecting shaft, small rolling is rolled on load-bearing guide rail for big rolling Dynamic, support of rolling about pallet, big rolling rotates in same direction with small rolling.Two chains driven in drive sprocket shaft are controlled by motor 111 Active movement is taken turns, two sprocket drivens movement in driven sprocket shaft, so that High speed chain be driven to rotate.On High speed chain Big rolling rotates in same direction with small rolling, and the transport of bearing tray is realized by frictional force.
Bearing tray deflection in order to prevent, the two sides of double-speed chain Transmission system are provided with side baffle 116, for stopping load-bearing Pallet is to double-speed chain Transmission system two sides deflection.Further, it in order to reduce the frictional force between bearing tray and side baffle, holds The two sides of weight pallet are provided with idler wheel, convert rolling friction for the sliding friction between bearing tray and side baffle 116.
To ensure bearing tray smoothly across cabin movement between each cabin, each intracorporal Transmission system in cabin is in adjacent cabin Joining place, side baffle 116 extend outward to form baffle guide plate 117, guide bearing tray smoothly across cabin movement.
The transmission unit 11 that sterilizes is equipped in one end close to the first hermatic door feeds stopper 118, and pallet is run to charging When at stopper 118, being stopped by charging stopper 118, charging cabin 1 carries out disinfecting action to pallet, after the completion of disinfecting action, the One hermatic door is opened, and charging stopper 118 declines, and the pallet after sterilizing strides into operational window 2, the first envelope under the driving of double-speed chain Closure door is closed.
For the collection bacterium efficiency for increasing entire isolator, several pallets are transported every time and are stacked, the switch gate of each hatch door is reduced Number.As shown in figure 3, in operational window 2, close 1 one end of sterilizing cabin of operation transmission unit 21 and close discharging 3 one end of cabin difference Equipped with tray separator structure 211 and stackable pallet mechanism 212, pallet fractionation and stackable pallet are carried out according to control instruction respectively.
Tray separator structure 211 and stackable pallet mechanism 212 be respectively arranged with close to discharging 3 side of cabin split stopper and Stack stopper.Tray separator structure 211 and 212 structure of stackable pallet mechanism are identical, by taking tray separator structure 211 as an example, by Lifting platform 2111 and elevating mechanism 2112, support, which refer to 2113 and hold in the palm, refers to that cylinder 2114 forms.
The pallet stacked is split the blocking of stopper stopper after entering operational window 2, and lifting platform 2111 is in elevating mechanism It is raised above under 2112 drive, after rising certain altitude, support refers to that 2113 internally move under the driving that support refers to cylinder 2114 The bottom of the pallet above bottom tray is held, stopper decline is split, bottom pallet drops to transmission unit with lifting platform On, stopper decline, bottom tray can continue to move on operation transmission unit, to realize the fractionation to stacking trays.
There is collection bacterium manipulator in operational window 2, between tray separator structure 211 and stackable pallet mechanism 212, collect bacterium machine Operation stopper and fine positioning pin are provided at tool hand.Stacking trays are hindered after the fractionation of tray separator structure by operation stopper Gear, fine positioning pin are inserted into the fine positioning hole of pallet, carry out fine positioning to pallet, behaviour is collecting bacteria by collecting bacterium manipulator at this time Make, after the completion of collection bacterium operation, fine positioning resets, and operation stopper decline, pallet continues to move forwards, and is stacked stopper resistance Gear.212 lifting platform of stackable pallet mechanism drives the pallet to rise, and is held by Tuo Zhi mechanism, when next pallet is stacked stopper It when blocking, holds in the palm and refers to reset, on a upper stackable pallet to next pallet, complete stackable pallet operation.
Discharging stopper is provided in discharging cabin 3.After stackable pallet, the second hermatic door is opened, and is stacked and is stopped Device decline, multiple layer tray strides into discharging cabin to be stopped by discharging stopper, and the second hermatic door is closed, and report information will simultaneously discharge out of my cabin Door is opened, convenient for manually taking out collection volva disk.
In order to realize the stacking between pallet, as shown in Figure 4 and Figure 5, support holder structure is as follows:
Pallet both ends are provided with tray handle 41, are convenient for artificial feeding early period.Pallet two sides are provided with directive wheel 42, are used for Cooperate with the side baffle 116 of Transmission system, pallet and 116 gap of side baffle can be prevented excessive, can reduce pallet and side Frictional force between baffle 116, when pallet crosses over cabin, directive wheel 42 and the cooperation of guide plate 117 make pallet smoothly cross over cabin Body realizes precisely transmission.
At least four support rods 43 are provided on tray upper surface, pallet is provided at least four and support rod on lower surface 43 location holes 44 matched, when needing to stack, the support rod 43 of lower tray supports the location hole for being located in upper tray In 44, realize that stablizing for pallet stacks.
In order to realize the operation requirement of higher precision, pallet side is provided with the fine positioning hole with the cooperation of fine positioning pin, can The repetitive positioning accuracy of 0.04mm is realized, convenient for carrying out accurate operation in operation cabin.
To distinguish pallet type, tray bottom has several notches 45, increases photoelectric sensor in Transmission system, The automatic identification of pallet type can be achieved.
Tray bottom is additionally arranged tray support plate 46, is convenient for reinforced tray intensity, prevents deformation after load-bearing from leading to positioning not It is quasi-.
The automatic running of entire isolator collection bacterium operation transmission system is realized by the control of control module.
Technical solution of the present invention and beneficial effect is described in detail in embodiment described above, it should be understood that Above is only a specific embodiment of the present invention, it is not intended to restrict the invention, it is all to be done in spirit of the invention Any modification, supplementary, and equivalent replacement etc., should all be included in the protection scope of the present invention.

Claims (10)

1. a kind of isolator collection bacterium operation transmission system characterized by comprising
Sterilize transmission unit, and setting is in sterilizing cabin, for having control pallet in sterilizing cabin for tray transport to operational window Stop sterilizing stopper;
Operation transmission unit is arranged in operational window, for having control pallet in operational window for tray transport to the cabin that discharges Stop operation stopper, also have to pallet carry out precise positioning precise positioning device;
Discharge transmission unit, and setting, for discharging, has the discharging resistance of stop of the control pallet in discharging cabin in discharging cabin Lug-latch;
Control unit issues the operation of instruction control sterilizing transmission unit, operation transmission unit and the transmission unit that discharges;
Successively gap is docked for the sterilizing transmission unit, operation transmission unit and discharging transmission unit, using speed chain haulage.
2. isolator collection bacterium operation transmission system according to claim 1, which is characterized in that the sterilizing transmission unit, The two sides of operation transmission unit and discharging transmission unit are provided with side baffle, for preventing pallet during the motion to transmission Unit two sides deflection.
3. isolator collection bacterium operation transmission system according to claim 2, which is characterized in that in pair of adjacent transmission cell Place is met, side baffle extends outward to form across cabin guide plate.
4. isolator collection bacterium operation transmission system according to claim 2, which is characterized in that pallet is provided on two sides Idler wheel.
5. isolator collection bacterium operation transmission system according to claim 1, which is characterized in that the operation transmission unit Feed end and discharge end are respectively arranged with tray separator structure and stackable pallet mechanism, respectively according to the control of described control unit Instruction carries out pallet fractionation and stackable pallet.
6. isolator collection bacterium operation transmission system according to claim 5, which is characterized in that the tray separator structure with The structure of stackable pallet mechanism is identical, is controlled by described control unit, comprising:
Lifting platform, positioned at the lower section of pallet running track, for going up and down the pallet being stacked with;
Elevating mechanism, for driving the lifting of lifting platform;
Support refers to, for holding up the pallet on lifting platform above bottom tray;
Support refers to cylinder, flexible for driving support to refer to.
7. isolator collection bacterium operation transmission system according to claim 5, which is characterized in that at the tray separator structure It splits stopper with being respectively arranged at stackable pallet mechanism and stacks stopper, be respectively used to control pallet and rest on pallet and tear open The top of sub-agencies or the lifting platform of stackable pallet mechanism.
8. according to right want 1 or 5 described in isolator collection bacterium operation transmission system, which is characterized in that the tray upper surface On be provided at least four support rods;At least four location holes matched with the support rod are provided on pallet lower surface.
9. according to right want 1 described in isolator collection bacterium operation transmission system, which is characterized in that tray bottom is provided with support Plate.
10. according to right want 1 described in isolator collection bacterium operation transmission system, which is characterized in that tray bottom is provided with coding Hole is provided with the photoelectric sensor for identifying the notch in Transmission system.
CN201910121369.0A 2019-02-19 2019-02-19 Isolator bacteria collection operation transmission system Pending CN109795857A (en)

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Application Number Priority Date Filing Date Title
CN201910121369.0A CN109795857A (en) 2019-02-19 2019-02-19 Isolator bacteria collection operation transmission system

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CN117025377A (en) * 2023-08-15 2023-11-10 瑞阳制药股份有限公司 Sterile automatic inspection equipment and method for finished injection medicine
CN117050868A (en) * 2023-08-15 2023-11-14 瑞阳制药股份有限公司 Sterile automatic inspection equipment and method for injection bulk drug

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CN110127291A (en) * 2019-06-24 2019-08-16 金华市唯创机械技术研发有限公司 An automatic assembly line equipment with a sterile protective structure
CN117025377A (en) * 2023-08-15 2023-11-10 瑞阳制药股份有限公司 Sterile automatic inspection equipment and method for finished injection medicine
CN117050868A (en) * 2023-08-15 2023-11-14 瑞阳制药股份有限公司 Sterile automatic inspection equipment and method for injection bulk drug
CN117050868B (en) * 2023-08-15 2024-04-23 瑞阳制药股份有限公司 Sterile automatic inspection equipment and method for injection bulk drug
CN117025377B (en) * 2023-08-15 2024-04-23 瑞阳制药股份有限公司 Sterile automatic inspection equipment and method for finished injection medicine

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Application publication date: 20190524