CN109793755A - A kind of resuscitation liquid for treating seawater immersion injury and its preparation method and application - Google Patents
A kind of resuscitation liquid for treating seawater immersion injury and its preparation method and application Download PDFInfo
- Publication number
- CN109793755A CN109793755A CN201811377139.2A CN201811377139A CN109793755A CN 109793755 A CN109793755 A CN 109793755A CN 201811377139 A CN201811377139 A CN 201811377139A CN 109793755 A CN109793755 A CN 109793755A
- Authority
- CN
- China
- Prior art keywords
- resuscitation fluid
- resuscitation
- seawater
- seawater immersion
- lavo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
本发明公开了一种用于治疗海水浸泡伤的复苏液及其制备方法与应用，按100ml所述复苏液计，包括生理盐水40‑60ml，5wt％葡萄糖溶液40‑60ml，右旋糖酐701.5‑2.5g，碳酸氢钠4‑6g。用本发明的复苏液对海水浸泡伤小型猪进行补液救治，可成功纠正其电解质紊乱，说明该复苏液的有效性。The invention discloses a resuscitation liquid for treating seawater immersion injuries, a preparation method and an application thereof. Calculated according to 100ml of the resuscitation liquid, it includes 40-60ml of physiological saline, 40-60ml of 5wt% glucose solution, and 701.5-2.5g of dextran. , 4-6g of sodium bicarbonate. Using the resuscitation solution of the present invention to rehydrate miniature pigs injured by seawater immersion can successfully correct the electrolyte imbalance, which shows the effectiveness of the resuscitation solution.
Description
Technical field
The present invention relates to the technical field of pharmaceuticals for trauma care, more particularly to one kind for treating seawater immersion wound
Resuscitation fluid and the preparation method and application thereof.
Background technique
Seawater is the liquid of a kind of hypertonic, alkaline, low temperature, rich bacterium, human body can be caused strong compound physicochemical irritation and
Pollution, is acute injury common in modern naval battle.Hurt different from traditional land battle, seawater immersion wound will lead to serious microcirculation
Obstacle, strong inflammatory reaction, tissue and cellular swelling, body fluid and electrolyte balance destruction and Abwehrkraft des Koepers decline, are secondary
Tissue damage, generation severe infection etc..
The drug that the seawater immersion wound of clinical practice treatment at present uses is mostly single component.Such as Publication No.
Tyrosol glucoside is disclosed in the Chinese invention patent application of CN101836998A is preparing the application in anti-hemorrhagic shock drug,
It is mentioned that related pharmacology experimental studies results are shown, tyrosol glucoside and tyrosol galactoside have significant anti-blood loss
Property shock activity, especially the haemorrhagic shock caused by anti-wound merge seawater immersion wound when activity it is more significant.Tyrosol sugar
Glycosides forms the colloidal solution of single component, can partially alleviate the Hypovolemias symptom such as ischemic, but not can solve seawater immersion wound
In electrolyte disturbance and disturbance of acid-base balance the problem of.In addition, the drug is Oral administration, absorbing slowly, conversion ratio is low,
It is limited to gastrointestinal function, is easy to cause in the comatose patient of part and has accidentally attracted the complication such as aspiration pneumonia.
Hyaluronic acid and its salt, cross-linked transparent are disclosed in the Chinese invention patent application of Publication No. CN101313915A
The application of matter acid and its salt in preparation treatment or prevention sea-soaking injury object.It is mentioned that hyaluronic acid and its salt, cross-linked transparent
Matter acid and its salt have skin attachment and hemostatic function in the swellability, good seawater barriering effect and water of appropriateness, can hurt
Protective layer is formed on mouthful, and has the function that quick-acting haemostatic powder, insulating sea water, is impregnated for preventing and treating the overboard rear seawater of the wounded
Wound is formed by Hai Pao and injures its complication, and promotes the healing of wound, and so it can only form separation layer in wound surface, temporarily
When property protection skin is further impregnated damage by seawater, cannot achieve the effect that fluid infusion is given treatment to.
Summary of the invention
The purpose of the present invention, in a first aspect, provide it is a kind of for treating the resuscitation fluid of seawater immersion wound, by described in 100ml
Resuscitation fluid meter contains physiological saline 40-60ml, 5wt% glucose solution 40-60ml, 1.5-2.5g macrodex, bicarbonate
Sodium 4-6g.
Based on resuscitation fluid described in 100ml, contain physiological saline 45-55ml, 5wt% glucose solution 45-55ml, 1.75-
2.25g macrodex, sodium bicarbonate 4.5-5.5g.
Based on resuscitation fluid described in 100ml, contain physiological saline 50ml, 5wt% glucose solution 50ml, 2g dextran
70, sodium bicarbonate 5g.
It also include lavo-ofloxacin and/or dexamethasone.
It include lavo-ofloxacin 0.1-1g and dexamethasone 2-8mg based on resuscitation fluid described in 100ml.
It include lavo-ofloxacin 0.3-0.7g and dexamethasone 4-6mg based on resuscitation fluid described in 100ml.
It include lavo-ofloxacin 0.5g and dexamethasone 5mg based on resuscitation fluid described in 100ml.
Second aspect, the present invention provide a kind of preparation method of above-mentioned resuscitation fluid, room temperature normal atmosphere pressure, first by physiology
Salt water and the mixing of 5wt% glucose solution, add macrodex, sodium bicarbonate, lavo-ofloxacin and dexamethasone, all
Filtration sterilization after dissolution, autoclave sterilization is to get the resuscitation fluid.
The third aspect, the present invention provide application of the above-mentioned resuscitation fluid in preparation treatment seawater immersion wound drug.
Resuscitation fluid of the invention using vein supplement by the way of be administered, can quickly, effectively, multichannel carry out simultaneously, do not have
Having time delay and obstruction, while circulating blood volume is replenished in time, additionally it is possible to electrolyte disturbance and disturbance of acid-base balance are corrected,
It is effectively improved shock symptom, achievees the purpose that give treatment in time.
Fluid infusion treatment is carried out to seawater immersion wound miniature pig by using resuscitation fluid of the invention, successfully corrects for its electrolysis
Matter disorder, it was demonstrated that the validity of the resuscitation fluid.Caused by dexamethasone in resuscitation fluid reduces body effective circulating blood volume
Shock has protective effect, can obviously correct the haemodynamics such as mean arterial pressure, cardiac output, cardiac index, stroke output
Index, while dexamethasone can protect intracellular lysosome, promote mitochondrial function.The ground plug rice being added in resuscitation fluid of the present invention
The ingredients such as pine and sodium bicarbonate, while actively supplying blood flow, moreover it is possible to it is flat to correct metabolic soda acid caused by seawater impregnates
Weigh the unbalance of disorder and electrolyte, and shock damage is minimized.
The present invention impregnates front and back change of electrolyte situation by the seawater of record miniature pig, and uses physiology salt by comparing
After water and resuscitation fluid fluid infusion of the present invention give correction to miniature pig electrolyte disturbance situation, learn resuscitation fluid of the invention to seawater
Impregnating wound has rescued effect, gives treatment to seawater immersion wound for clinical Transformation Application resuscitation fluid in next step and lays the foundation.
The seawater immersion wound animal model established in the present invention to examine resuscitation fluid to treat the effect of seawater immersion wound is built
Vertical process is simple, and operability and replicability are strong, can provide miniature pig relevant physiological, disease after seawater immersion wound evil well
Pharmacological data, so as to miniature pig is held according to data situation ordinary circumstance and resuscitation fluid to its therapeutic effect.
Specific embodiment
Hypertonic seawater immersion most starts that hypoxemia and high carbon acid environmental damage can be caused to local organization, causes local microcirculation
Obstacle, and then the physiological and pathological variation for causing body systemic, such as hyperosmotic dehydration, high blood coagulation state, multiple microthrombus
It is formed, leads to serious haemodynamics and electrolyte disturbance.There is research to confirm, seawater, which impregnates 2h, can cause body blood flow
Mechanics serious diseases.
Seawater, which impregnates, to cause the disorder of electrolyte, mechanism master by the damage to liver, pancreas, kidney and heart internal organs
It wants are as follows: 1, reduction effective blood volume: dialysis effect can produce by the hypertonicity attribute of seawater, cause the moisture in extracellular fluid big
Outlet is measured, the sharply reduction of circulating blood volume is in turn resulted in；2, influence gut cell metabolism: effective circulating blood volume reduction causes cell
Interior dehydration can lead to intracellular and organism metabolism acid poisoning, while generate the electrolyte disturbances such as potassemia, hyperchloremia；
3, free radical accumulation exacerbation damage: metabolic acidosis stimulates peroxidation lipid reactant to enhance, and a large amount of free radical accumulations add
Acute peroxidization, while keeping respiratory chain impaired, the further disorder of energetic supersession.
The present invention on this basis, proposes a kind of resuscitation fluid, and the electrolysis of front and back miniature pig is impregnated by being recorded in seawater
Matter situation of change, and use physiological saline and resuscitation fluid fluid infusion of the present invention to the correction feelings of miniature pig electrolyte disturbance by comparing
Condition, obtain the resuscitation fluid can correct impregnated because of seawater caused by electrolyte disturbance, have rescued effect to seawater immersion wound, to be next
Clinical Transformation Application resuscitation fluid treatment seawater immersion wound is walked to lay the foundation.
Below in conjunction with specific embodiment, the content of the present invention will be explained in more detail, and the present invention is further elaborated, but
These embodiments limit the invention absolutely not.
Inventor has found in the course of the research: low colloidal solution can more stable maintenance blood volume, increase urine volume, and can be compared with
Hyperlipidemia is corrected well and avoids lung, brain edema.The mechanism that low colloidal solution plays a role may be related with following several ingredients:
(1) liquid of sodium chloride, low concentration more can gently reduce osmotic pressure, avoid osmotic pressure rapid decrease cause to cause brain,
The generation of pulmonary edema.(2) dextran can cooperate with inflation fluid capacity, attract moisture to enter by its colloid osmotic pressure
Lumen of vessels maintains dilatation, and can reduce the generation of lung, brain edema；On the other hand, the dextrorotation of the small molecule with negative electrical charge
Sugared acid anhydride can inhibit platelet adhesion reaction, reduce blood viscosity, inhibit negatively charged neutrophil adhesion on endothelial cell, can
The obstruction of microcirculation after suffering a shock is reduced, microcirculation and blood fluidity are improved.(3) glucose provides necessary energy for body,
Be conducive to organ dysfunction recovery.
Therefore resuscitation fluid proposed by the present invention, belongs to low colloidal solution according to component ratio, can be after seawater immersion wound
Alleviate osmotic pressure at the first time to increase, dilatation blood vessel is effectively improved circulation blood flow, reduces Accessory injury caused by suffering a shock.
It is molten containing 5wt% glucose by taking 100ml as an example provided by the present invention for treating the resuscitation fluid of seawater immersion wound
Liquid 40-60ml, 1.5-2.5g macrodex, sodium bicarbonate 4-6g, surplus is physiological saline；Preferably, containing 5wt% grape
Sugar juice 45-55ml, 1.75-2.25g macrodex, sodium bicarbonate 4.5-5.5g, surplus is physiological saline；Most preferably, it wraps
Include physiological saline 50ml, 5wt% glucose solution 50ml, 2g macrodex and 5g sodium bicarbonate.
Wherein, the effect of physiological saline is that supplement body fluid is lost, this is because because body is in seawater in seawater immersion wound
With high salt, high environment in, intracellular fluid is known from experience to extracellular transfer, and body entirety body fluid is caused to be lost.Physiological saline can
The quickly body fluid that supplement is lost restores the normal inorganic salt concentration of intraor extracellular environment and osmotic pressure.
The effect of 5wt% glucose solution is to provide energy, this is because whole body mobilizes heat production to protect after seawater immersion wound
The normal temperature of body is held, and glucose is the main resources of energy supply, so body can show in seawater immersion wound
The state of hypoglycemia, is replenished in time glucose, can reduce the consumption to body glycogen.
Macrodex is used to adjust fluid infusion tension, liquid tension, and film two sides volume is changed, and pressure also has occurred
The balance pressure of variation, this solution maintained by infiltration is exactly osmotic pressure, refers to fluid pressure.The tension of seawater is big, body
Internal liquid tension is small, so will appear liquid tension disorder in seawater immersion wound.It can be restored using macrodex
The normal tension of soma internal and external environment reduces because of cell shrinkage caused by tension change or rises brokenly.
Sodium bicarbonate is used to adjust pH value, and the mistake for leading to acid-base balance buffering pair can be lost because of body fluid in seawater immersion wound
There is the state of slant acidity in weighing apparatus, therefore the alkaline side of internal acid-base balance buffering pair is supplemented using sodium bicarbonate.
Seawater immersion wound has the redistribution of body fluid, causes body oedema.In order to mitigate body oedema, can also it be added ground
Sai meter Song, dexamethasone belong to Aeroseb-Dex, have the function of anti-inflammatory, antiallergy, Hemorrhagic shock.
Body anti-infection ability sharply declines after seawater immersion wound, meanwhile, complicated component is infected in seawater, containing there are many thin
Bacterium easily leads to organism infection.For antibacterial anti-infection, lavo-ofloxacin can also be added, lavo-ofloxacin belongs to quinolones
One of drug has broad-spectrum antibacterial action, and antibacterial action is strong, to most enterobacteriaceae lactobacteriaceaes, such as escherichia coli, Cray
The leather such as primary Pseudomonas, Proteus, Salmonella, Shigella and haemophilus influenzae, legionella pneumophilia, NEISSERIA GONORRHOEAE is blue
Negative bacterium has stronger antibacterial activity.To gram positive bacterias such as staphylococcus aureus, streptococcus pneumonia, micrococcus scarlatinaes and
Mycoplasma pneumoniae, chlamydia pneumoniae also have antibacterial action.
Lavo-ofloxacin 0.1-1g and dexamethasone 2-8mg can also be contained in resuscitation fluid of the invention；Preferably, including
Lavo-ofloxacin 0.3-0.7g and dexamethasone 4-6mg；Most preferably, lavo-ofloxacin 0.5g, dexamethasone 5mg.
The present invention also provides a kind of preparation method of above-mentioned resuscitation fluid, specifically: first by physiological saline and 5wt% grape
Sugar juice mixing, adds macrodex, sodium bicarbonate, dexamethasone and lavo-ofloxacin, is completely dissolved rear filtration sterilization,
Autoclave sterilization to get arrive resuscitation fluid of the invention.
Resuscitation fluid of the invention is when in use by the way of intravenous drip, the case where being suffered a shock according to body and the state of an illness
Critical situation is given according to height, the weight of Hemorrhagic shock fluid infusion formula combination patient by clinician and is supplemented, the electrolysis to patient
Matter index and other biochemical indicators restore normal, can stop instiling.
Embodiment
According to above-mentioned preparation method, a series of present invention are prepared for treating the resuscitation fluid of seawater immersion wound, group
At being shown in Table 1.
The composition of resuscitation fluid of 1 present invention of table for treating seawater immersion wound
Experimental example
One, material and method
1, the configuration of artificial seawater
Experiment manually seawater with reference to the Second Institute of Oceanograghy,SOA provide China's southeastern coast seawater mainly at
Point, and (such as Xue little Jun, Zhang Wenhua, the such as all pines impregnate rabbit open abdomen to seawater using ulinastatin in early days after hurting to combination document
Intervention effect [J] liberation army medical journal of wound, 2013,25:35-38. etc.) report preparation, specific ingredient are as follows: sodium chloride
26.5g/L, magnesium sulfate 3.3g/L, magnesium chloride 2.45g/L, calcium chloride 1.14g/L, potassium chloride 0.73g/L, sodium bicarbonate 0.2g/
L, sodium bromide 0.08g/L, osmotic pressure 1250-1350mmol/L, pH 7.9-8.1, sea water specific gravity 1.020-1.025 are put down
Equal temperature is 22 DEG C.
2, the foundation of animal model
Miniature pig has extensive similitude in all many-sided and mankind such as anatomy, physiological metabolism, is that we carry out base
The ideal animals of plinth medical research.Currently, having been used in surgical skills raising, anesthesia using miniature pig as the animal model of research object
Medicine selection, cardiovascular and cerebrovascular disease, digestive system tumor, endocrine system disease, Living organ transplantation, stem cell culture and burn are outer
Section etc. is used widely.There is important biomedical valence by the experimental data and index of establishing animal model acquisition
Value, to instruct preclinical medicine even clinic study to provide good reference function.Therefore, the present invention use miniature pig as
The animal pattern of this experiment.
4 monthly age Guizhou III are miniature pig, half male and half female, weight 14-18kg.Using ketamine neuromuscular block (10mg/kg),
Trachea cannula, intravenous injection 2wt% Nembutal sodium solution (15-20mg/kg) maintain anesthesia.Experimental animal (upright position) is set
In on fixed frame, immersing artificial seawater, seawater impregnates plane up to 5cm on xiphoid-process, impregnates 3h, seawater immersion wound Animal Model
It completes.
3, test medicine
The resuscitation fluid of embodiment 1-8, the resuscitation fluid of comparative example 1-8, physiological saline (comparative example 9) in table 1 are taken respectively
The mode of intravenous drip is infused in miniature pig body, and 55mL/kg, 30min or so has instiled, after completing administration, in narcosis
The general vital sign for maintaining miniature pig, acquires the vena cava anterior blood of miniature pig, and chemical examination obtains every physical signs of miniature pig.
4, Testing index
Na in the pH value of small-sized porcine vein, serum+Concentration, K+Concentration and Cl-Concentration.Data with mean ± standard deviation (±
S) it indicates, statistical procedures use 19.0 statistical package of SPSS, and related data uses paired t-test, and P < 0.05 has for difference
Statistical significance.Experimental result is shown in Table 2 and table 3.
5, experimental result
1) front and back electrolyte Indexes Comparison is impregnated:
Variation of 2 electrolyte parameter of table before and after seawater immersion
By the number of statistical form 2 it has been found that Guizhou III is miniature pig after seawater immersion, the pH of two groups of small-sized porcine veins
Na in value, serum+Concentration, K+Concentration and Cl-Conspicuousness variation (p < 0.05) all has occurred in concentration.Wherein pH value is remarkably decreased, i.e.,
Blood pH acidification, is presented the performance of acid poisoning.It is corresponding K occur+Concentration and Cl-The different degrees of raising of concentration embodies
For postacidotic potassemia and hyperchloremia.Na in serum+Slight decline also has occurred in concentration, drops to respectively
136.8 ± 4.32mmol/L and 136.90 ± 3.03mmol/L.
2) fluid infusion electrolyte Indexes Comparison is grouped after impregnating:
By taking embodiment 5 as an example, it the results are shown in Table 3.
Correction situation of the 3 two kinds of resuscitation fluids of table to miniature pig electrolyte disturbance after seawater immersion wound
Table 3 the result shows that, after the resuscitation fluid fluid infusion of embodiment 5, small-sized porcine vein pH value is increased to 7.385 ±
0.03 (p < 0.05), and is no different before immersion, illustrates that acid poisoning performance is corrected.K in serum+Concentration and Cl-Concentration declines respectively
To 3.87 ± 0.25mmol/L and 94.15 ± 4.2mmol/L (p=0.005, p=0.007), do not shown with the index before immersion
Write difference.Na in serum+Concentration goes back up to 136.90 ± 3.03mmol/L, concentration normal level close to before impregnating.Miniature pig
Na in venous blood pH value, serum+Concentration, K+Concentration and Cl-Concentration restores the level to before impregnating, and illustrates recovery of the invention
Liquid can correct electrolyte disturbance caused by seawater immersion wound, can treat seawater immersion wound.
And indices change with unknown significance after immersion after the physiological saline fluid infusion of comparative example 9, illustrate comparative example 9
Physiological saline there is no therapeutic effect to seawater immersion wound.
Other embodiments and the data of comparative example are shown in Table 4.
Correction situation of other resuscitation fluids of table 4 to miniature pig electrolyte disturbance after seawater immersion wound
To sum up, seawater immersion wound animal model prepared in the present invention, modelling process is simple, operability and can
Generalization is strong, can be good at miniature pig relevant physiological, pathology data variation after offer seawater immersion wound evil, and can be according to number
Miniature pig ordinary circumstance is held according to situation of change dynamic.The present invention use by comparing resuscitation fluid to seawater immersion wound miniature pig into
Row fluid infusion treatment, successfully corrects for its electrolyte disturbance, it was demonstrated that the resuscitation fluid validity has certain clinical medical value.
The above is only a preferred embodiment of the present invention, it is noted that for the common skill of the art
For art personnel, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications
Also the contents of the present invention be should be regarded as.
Claims (9)
1. a kind of for treating the resuscitation fluid of seawater immersion wound, which is characterized in that based on resuscitation fluid described in 100ml, contain physiology
Salt water 40-60ml, 5wt% glucose solution 40-60ml, 1.5-2.5g macrodex, sodium bicarbonate 4-6g.
2. resuscitation fluid according to claim 1, which is characterized in that based on resuscitation fluid described in 100ml, contain physiological saline 45-
55ml, 5wt% glucose solution 45-55ml, 1.75-2.25g macrodex, sodium bicarbonate 4.5-5.5g.
3. resuscitation fluid according to claim 1, which is characterized in that based on resuscitation fluid described in 100ml, contain physiological saline
50ml, 5wt% glucose solution 50ml, 2g macrodex, sodium bicarbonate 5g.
4. -3 any resuscitation fluid according to claim 1, which is characterized in that also include lavo-ofloxacin and/or dexamethasone.
5. resuscitation fluid according to claim 4, which is characterized in that include lavo-ofloxacin based on resuscitation fluid described in 100ml
0.1-1g and dexamethasone 2-8mg.
6. resuscitation fluid according to claim 5, which is characterized in that include lavo-ofloxacin based on resuscitation fluid described in 100ml
0.3-0.7g and dexamethasone 4-6mg.
7. resuscitation fluid according to claim 6, which is characterized in that include lavo-ofloxacin based on resuscitation fluid described in 100ml
0.5g and dexamethasone 5mg.
8. a kind of preparation method of any resuscitation fluid of claim 1-7, which is characterized in that the pressure of room temperature normal atmosphere, first
Physiological saline and 5wt% glucose solution are mixed, macrodex, sodium bicarbonate, lavo-ofloxacin and ground plug rice are added
Pine, all filtration sterilizations after dissolution, autoclave sterilization is to get the resuscitation fluid.
9. any resuscitation fluid of claim 1-7 is applied in preparation treatment seawater immersion wound drug.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711146793 | 2017-11-17 | ||
| CN2017111467938 | 2017-11-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109793755A true CN109793755A (en) | 2019-05-24 |
Family
ID=66556331
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811377139.2A Pending CN109793755A (en) | 2017-11-17 | 2018-11-19 | A kind of resuscitation liquid for treating seawater immersion injury and its preparation method and application |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109793755A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1732972A (en) * | 2005-08-08 | 2006-02-15 | 刘晓曼 | Dextran for injection and method for preparing the same |
| CN103830166A (en) * | 2012-11-22 | 2014-06-04 | 北京四环制药有限公司 | Preparation method of hypertonic resuscitation fluid and application thereof |
-
2018
- 2018-11-19 CN CN201811377139.2A patent/CN109793755A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1732972A (en) * | 2005-08-08 | 2006-02-15 | 刘晓曼 | Dextran for injection and method for preparing the same |
| CN103830166A (en) * | 2012-11-22 | 2014-06-04 | 北京四环制药有限公司 | Preparation method of hypertonic resuscitation fluid and application thereof |
Non-Patent Citations (3)
| Title |
|---|
| 乔治等: ""一种新型复苏液对海水浸泡伤小型猪电解质紊乱纠正的效果分析"", 《国际外科学杂志》 * |
| 刘卫等主编: "《战时伤病的合理用药》", 30 November 2014, 第二军医大学出版社 * |
| 王志伟等: ""两种低张胶体液对腹腔海水浸泡伤战地救治的早期效果术"", 《中国现代医学杂志》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Southwick et al. | Recovery after prolonged asystolic cardiac arrest in profound hypothermia: a case report and literature review | |
| Collins | Massive blood transfusion | |
| CN102949709B (en) | A kind of external gel for treating diabetic foot and its preparation and application | |
| US6986905B1 (en) | Pharmaceutical compositions for treating and saving and the method for the preparation thereof | |
| US5082831A (en) | Total body washout solution and method of use | |
| De Villota et al. | Recovery from profound hypothermia with cardiac arrest after immersion | |
| MX2014014502A (en) | Methods of administering nitric oxide to arterial or arterialized blood. | |
| Horton et al. | Arginine in burn injury improves cardiac performance and prevents bacterial translocation | |
| KR20100017183A (en) | Body-temperature lowering depressant | |
| Tompkins et al. | Burn therapy 1985: acute management | |
| CN109793755A (en) | A kind of resuscitation liquid for treating seawater immersion injury and its preparation method and application | |
| RU2122415C1 (en) | Method of intensive therapy of patients with traumatic shock | |
| Dietzman et al. | High-output, low-resistance gram-negative septic shock in man | |
| WO2019168063A1 (en) | Peritoneal dialysate fluid, peritoneal dialysate fluid set, composition for use in peritoneal dialysis, and peritoneal dialysis method | |
| Button | Paper 3: Fluid therapy in canine babesiosis | |
| ES2382513B2 (en) | Dialysis solution containing at least one CCR2 antagonist | |
| Friend | Iron ascorbate in the treatment of anemia | |
| Arturson | Management of burns | |
| CN107753505A (en) | A kind of Multiple electrolytes injection | |
| CN111053788B (en) | Composition for adjuvant therapy of chronic hemorrhage and application thereof | |
| HAYNBS JR | The management of burns in children | |
| Shepard | The Impact of Diabetes Mellitus on Burns and Standard Burn Treatments | |
| Yusupov et al. | Features of perioperative management of children with diffuse appendicular peritonitis. | |
| CN108272819A (en) | A kind of aspartic acid Multiple electrolytes injection and preparation method thereof | |
| Manoj et al. | Anaesthetic Management Of A Patient In Sickle Cell Crisis With Empyema Gall Bladder |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20190524 |