CN109793501A - A non-invasive detection device for human metabolic health index - Google Patents
A non-invasive detection device for human metabolic health index Download PDFInfo
- Publication number
- CN109793501A CN109793501A CN201910179479.2A CN201910179479A CN109793501A CN 109793501 A CN109793501 A CN 109793501A CN 201910179479 A CN201910179479 A CN 201910179479A CN 109793501 A CN109793501 A CN 109793501A
- Authority
- CN
- China
- Prior art keywords
- skin
- light source
- excitation light
- human
- fluorescence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Abstract
本发明涉及一种人体代谢健康指数无创检测设备，包括：多光谱激发光源，由多个波长的LED或者激光二极管组成；校准光源，由紫光LED和白光LED组成，覆盖了从400nm到700nm的光谱区域；光谱采集设备，用于测量皮肤荧光光谱的信号；3叉光纤探头装置，连接光源和光谱采集设备，传输光信号。本发明的多光谱激发光源，可以激发皮肤的多种荧光物质，根据荧光的强弱来判断人体的健康状况。由于人体的皮肤肤色不同，有黑有白，皮肤白的人荧光要强一些，为了消除这种影响，需要用校准光源来照射皮肤，采集皮肤的宽带反射光谱，来对皮肤的荧光光谱的强弱进行校正。本发明不需要进行采血操作，属于无创检测，而且几十秒内就可以知道测试结果，采集方便，迅速快捷，这是传统检测人体健康指数所不具有的优势。
The invention relates to a non-invasive detection device for human metabolic health index, comprising: a multi-spectral excitation light source, which is composed of LEDs or laser diodes with multiple wavelengths; area; spectrum acquisition equipment, used to measure the signal of skin fluorescence spectrum; 3-pronged fiber optic probe device, connected to the light source and spectrum acquisition equipment, to transmit optical signals. The multi-spectral excitation light source of the present invention can excite various fluorescent substances in the skin, and judge the health status of the human body according to the intensity of the fluorescence. Because the skin color of the human body is different, there are black and white, and people with white skin have stronger fluorescence. In order to eliminate this effect, it is necessary to illuminate the skin with a calibrated light source, and collect the broadband reflection spectrum of the skin to determine the intensity of the skin's fluorescence spectrum. Make corrections. The invention does not require blood collection operation, belongs to non-invasive detection, and can know the test result within tens of seconds, and the collection is convenient, rapid and fast, which is the advantage that the traditional detection of human health index does not have.
Description
Technical field
The present invention relates to biologic medical testing equipment fields, and in particular to a kind of Non-invasive detection equipment.More specifically, originally
Invention provides a kind of a kind of Non-invasive detection equipment that skin fluorescence analysis is carried out using ultraviolet, visible or near infrared light, is used for
Evaluate the metabolic health situation of human body.
Background technique
The metabolism of human body is the summation that all life maintain biochemistry and biophysics process.Metabolism varies with each individual, and
And change with the lifetime, in addition it additionally depends on many other factors, such as body & mind pressure or disease.Pass through
Using metabolic analysis, the overall understanding to the present health condition of human organism may be implemented.So far, metabolic analysis is only
Using only the conclusion of different single inspection methods, these methods are costly and time consuming.Specifically, these methods are that organ is living
The lab analysis of property, immune system, endocrine system, lipid metaboli, mineral metabolism.
So far, blood sample is sent to assay laboratory and analyzed by metabolic analysis there is still a need for acquiring and analyzing blood sample.
In addition to the expense, the shortcomings that there are also other.Due to the analysis duration transported and grown, blood sample can morph (for example,
Oxidation reaction, Hirschfeld-Klinger reaction), this will affect the result of inspection.In addition, acquisition blood sample is very inconvenient for the patient, and
Sometimes, even with danger.In addition, the various spectrometer equipments of the fluorescence properties for optical check biological organization sample
It is known in the prior art.The protein of the biological substance of each species has intrinsic fluorescence, for example, porphyrin, aromatics
Amino acid, riboflavin, NADH, tryptophan etc..One is disadvantageous in that biological organization sample must be taken from test object
Out, then before being optically inspected, it is necessary to be placed in sample carriers or bulb.
The inspection method of the prior art occurs in laboratory, and is not suitable for each in the environment that works or recuperate
Checking at once and quickly to tester under a occasion.In addition, these methods needs carry out on body parts
Interventional procedure.
In short, existing detection method needs, blood was collected, the assay time is longer, to wanting for the site surrounding of detection
The risk asked higher, and there is sample to fail.
Summary of the invention
The technical problem to be solved in the present invention: a kind of body metabolism health index has been overcome the deficiencies of the prior art and provide
Non-invasive detection equipment, do not need to take a blood sample, operating environment requirements are not high, can be detected in many circumstances, and tens seconds are just
It can be detected as a result, detecting simple and fast.
The technical solution adopted by the present invention is that: a kind of Non-invasive detection equipment of body metabolism health index, comprising:
Multispectral excitation light source can issue the exciting light of multi-wavelength, be made of multiple LED or laser diode,
And spectral width is very narrow, is mainly used for exciting the fluorescent material of skin；
Regulation light source is made of purple LED and white light LEDs, issues the broadband light that can cover 400-700nm wave band
Spectrum, for calibrating influence of the colour of skin to fluorescence of human skin；
Spectra collection equipment, for acquiring the fluorescence signal of human skin；
3 fork optical-fiber probe devices, for connecting multispectral excitation light source, wideband light source, spectra collection equipment, transmission light letter
Number.
The excitation light source of 4 different wave lengths, a variety of Endogenous fluorophores in exciting human, the strong and weak reflection of fluorescence spectrum
The metabolic health situation of human body；The excitation light source of 4 different wave lengths is respectively that 280nm, 370nm, 405nm and 450nm swash
Light emitting source.
Wherein, multispectral excitation light source can issue the exciting light of a variety of different wave lengths, the spectral width of every kind of exciting light
Very narrow, intensity is very high, and for the fluorescent material in exciting human skin, the light source of different excitation wavelengths can be with exciting human skin
Interior different fluorescent material, obtains different fluorescence spectrums.Regulation light source is made of purple LED and white light LEDs, issues one
The broadband spectral of 400-700nm wave bands can be covered.Since the skin complexion of human body is all variant, the white people's fluorescence meeting of skin
Strong, the black people's fluorescence of skin can be weaker.In order to eliminate the influence of skin complexion, surveys before fluorescence, first use regulation light source
Skin is irradiated, a broadband reflection spectrum is obtained, fluorescence spectrum is modified according to reflectance spectrum.Make the fluorescence spectrum surveyed
Can in actual response human skin fluorescent material content, be capable of the metabolic health situation of actual response human body.
In the multispectral excitation light source, within 10nm, various exciting lights are radiated at the spectral width of every kind of exciting light
On skin, the fluorescence of multiple fluorescent substance in skin is inspired, the fluorescent material in skin includes NADH, riboflavin, tryptophan；
Different exciting lights is selected, the fluorescence spectrum for inspiring the fluorescent material in skin is also different.
In the regulation light source, in order to eliminate influence of the skin complexion to fluorescence intensity, multispectral excitation light source is being used
It irradiates before skin, first skin is irradiated with regulation light source, according to skin to the broadband reflection spectrum of regulation light source, to recalibrate
Fluorescence spectrum keeps the fluorescence of the fluorescent material in fluorescence spectrum actual response human skin strong and weak, actual response human body
Metabolic health situation.
The 3 fork optical-fiber probe device, for one of probe for contacting skin, other connectors are multispectral for connecting
Excitation light source, regulation light source and spectra collection equipment transmit ultraviolet, visible or near infrared band.
The 280nm excitation light source excites the tryptophan in skin, the update of plasma proteins in tryptophan participant's body,
And riboflavin is promoted to play a role；When lacking tryptophan, it may appear that growth retardation, weight loss, Fat Accumulation reduce.
Glycosylation end products in the 370nm excitation light source excitation skin, the cumulant reflection one of glycosylation end products
The degree of risk of personal diabetes and its complication.
Porphyrin in the 405nm excitation light source excitation skin, porphyrin is the necessary substance in red blood cell synthesis process, is lacked
Weary porphyrin will lead to anaemia, and porphyrin accumulation excessively will cause porphyrism in human body.
Riboflavin in the 450nm excitation light source excitation skin, that is, vitamin B2, riboflavin are growth in humans
Required factor, promotes development and the regeneration of cell, promotes the normal growth of skin, nail, hair.
The course of work of the invention is as follows:
(1) multispectral excitation light source can issue the exciting light of tetra- kinds of wavelength of 280nm, 370nm, 405nm, 450nm, shine
Penetrate the fluorescence that different fluorescent materials in skin can be excited on human skin；
(2) regulation light source can issue the broadband spectral of 400nm -700nm, be made of ultraviolet LED and white light LEDs, and two
Lamp bead works at the same time luminous.Due to the skin of human body have it is black have it is white, the white people's fluorescence of skin more by force, the black people's fluorescence of skin
It is weaker.In order to eliminate this influence, in excitation skin before the fluorescence of fluorescent material, skin first is irradiated with regulation light source
Skin obtains the reflectance spectrum of a 400nm -700nm, then irradiates skin with excitation light source again to excite fluorescence.In this way, with
For the signal value of fluorescence divided by the reflected spectrum of skin, this ratio can objectively reflect the fluorescent material in human skin very much
Content；
(3) content of different fluorescent materials and the health status of human body are closely bound up in human skin, according to fluorescent material
Fluorescence signal and skin reflex spectrum ratio, can be very good reflection human skin in fluorescent material content, thus
Know the health status of human body.
The beneficial effects of the present invention are:
(1) traditional metabolic health index detection requires to take a blood sample, and the time of consuming is very long, and in the detection process,
Sample has a risk of failure, and the light source of device used in the present invention is LED or laser, light intensity all in safe range,
Irradiation skin will not bring any feeling to people, belong to Non-invasive detection, do not need to take a blood sample, be free from side effects.
(2) device used in the present invention only needs tens seconds time to can be obtained by testing result, simple and fast.And
Traditional method needs assay, takes a lot of time, this is that the blood sampling detection of traditional metabolic health index does not have
Advantage.
(3) traditional blood sampling assay method is very high to workplace and environmental requirement, and the present invention can be very much
Detection is operated under site surrounding.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of entire body metabolism health index Non-invasive detection equipment, wherein 1 is 3 fork fibre-optical probes
Device, 2 be multispectral excitation light source, and 3 be regulation light source, and 4 be spectra collection equipment.
Fig. 2 is the schematic diagram of multispectral excitation light source, wherein 21 be 280nm excitation light source, and 22 be 370nm excitation light source,
23 be 405nm excitation light source, and 24 be 450nm excitation light source.
Fig. 3 is the schematic diagram of 3 fork optical-fiber probe devices, wherein 11 be the probe for contacting human skin, and 12 be connection mostly light
The connector of excitation light source is composed, 13 be the connector for connecting regulation light source, and 14 be the connector for connecting spectra collection equipment.
Fig. 4 is the fibre core distribution schematic diagram of fibre-optical probe, wherein 7 fibres are distributed in the probe 11 of contact human skin
Core is with 6 core diameters outside, wherein 5 are exciting light fibre cores, 1 is regulation light source core diameter, and intermediate fibre core collects fluorescence letter
Number, it is transferred to spectra collection equipment 4.
Specific embodiment
The present invention will be further described in detail below with reference to the accompanying drawings and specific embodiments.
As shown in Figure 1, a kind of body metabolism health index Non-invasive detection equipment of the invention, by 3 fork optical-fiber probe devices
1, multispectral excitation light source 2, regulation light source 3 and spectra collection equipment 4 form.
As shown in Fig. 2, multispectral excitation light source 2 is made of the excitation light source of multiple wavelength, including 280nm excitation light source
21,24 4 370nm excitation light source 22,405nm excitation light source 23,450nm excitation light source light sources, 280nm excitation light source 21 can
To excite the tryptophan in skin, tryptophan may participate in the update of plasma proteins in human body, and riboflavin can be promoted to play and made
With.When lacking tryptophan, it may appear that growth retardation, weight loss, Fat Accumulation reduce；370nm excitation light source 22 can excite
How much AGE (glycosylation end products) in skin, AGE content can reflect the degree of risk of people's diabetic complication；
405nm excitation light source 23 can excite the porphyrin in skin, and porphyrin is the necessary substance in red blood cell synthesis process, lack porphyrin meeting
Lead to anaemia, porphyrin accumulation excessively will cause porphyrism in human body；450nm excitation light source 24 can excite the riboflavin in skin,
Namely vitamin B2, riboflavin are the required factors of growth in humans, can promote development and the regeneration of cell, can promote skin
Skin, nail, hair normal growth.Each light source can be LED or laser diode, the spectral width that each light source issues
All very narrow, LED light source can be realized by adding narrow band filter.Fluorescent material there are many in human skin, such as NADH,
Porphyrin or tryptophan etc., every kind of fluorescent material can inspire fluorescence by the exciting light of corresponding excitation wavelength,
The metabolic health situation of human body is judged according to the fluorescence power of every kind of fluorescent material.
As shown in figure 3, multispectral excitation light source 2 and 3 pitches the connector of the multispectral excitation light source of connection of optical-fiber probe device 1
12 are connected.The connector 13 of the connection regulation light source of 3 fork optical-fiber probe devices 1 is connected with regulation light source 3.Regulation light source 3 is
It is made of purple LED and white light LEDs, covers the broadband spectral of 400-700nm.Since the skin complexion of human body is all to have difference
Different, the fluorescence that the white people of skin inspires is eager to excel, and the fluorescence that the black people of skin inspires is weaker.In order to eliminate this
Kind influences, and before fluorescence detection, the broadband light for first opening 3,400-700nm of regulation light source can obtain one on the skin
The reflectance spectrum of a skin.The white people's reflectance spectrum of skin is just strong, is then shut off regulation light source, opens excitation light source, excites skin
The influence factor of the reflectance spectrum of regulation light source 3 will be considered when skin fluorescence, calibration obtains a reasonable fluorescence spectrum,
The fluorescence for the fluorescent material in fluorescence spectrum actual response human skin that detection is obtained is strong and weak, can really reflect
The metabolic health situation of human body.The probe 11 of the contact human skin of 3 fork optical-fiber probe devices 1 and the skin contact of human body.It is more
The exciting light that excitation of spectra light source 2 issues enters light from the connector 12 of the multispectral excitation light source of connection of 3 fork optical-fiber probe devices 1
Fibre comes out from the probe 11 of contact human skin by transmission and irradiates on the skin, and light is irradiated to human skin tissue surface
Afterwards, a part of light is entered in skin histology by skin surface diffusing reflection, a part of light emission.Inject light a part in skin histology
It is absorbed by tissue and the fluorescent material in skin histology is caused to generate fluorescence, a part scatters.The optical propagation direction of scattering
It will change, a part of light, which will change by continuous direction from skin surface, to be transmitted, and then enters contact again
The probe 11 of human skin.
As shown in figure 4,7 core diameters are distributed in the end face of the probe 11 of contact human skin, it is with 6 core diameters outside, it is intermediate
There is a core diameter, wherein 6 core diameters of periphery there are 5 for receiving exciting light, in addition a core diameter is for receiving regulation light source
Light, intermediate core diameter be used to collect fluorescence；The connector 12 of multispectral excitation light source is connected for receiving exciting light, there are 5 cores
Diameter can transmit optical signal, and in addition 2 are blind set core, do not transmit optical signal, and the position of 5 core diameters and 2 blind set cores is as shown in Figure 3；
Exciting light is from 5 core diameter incidences of periphery, and into skin, after inspiring fluorescence, fluorescence is appeared from skin surface, into contact people
Then that root core diameter of the centre of the probe 11 of body skin enters spectra collection equipment 4 by the connector 14 of contact human skin, most
The data processing of fluorescence signal is carried out afterwards.The single of the broadband light of 400-700nm of regulation light source 3 from periphery is incident, into skin
Skin, reflectance spectrum are collected by the core diameter among the probe 11 of contact human skin, are then communicated to spectra collection equipment 4, into
Row signal calibration.3 fork optical-fiber probe devices 1 can transmit ultraviolet, visible or near infrared band optical signal.Spectra collection is set
For 4, fluorescence signal and calibration signal, progress Data Analysis Services, the fluorescent material obtained in human skin contain based on the received
Amount, to judge the metabolic health situation of human body.
Detection device of the present invention does not need to take a blood sample, and is a kind of Non-invasive detection equipment, and can go out within tens seconds after detecting
As a result, it is simple and quick, the processes such as assay are avoided, many times can be saved, it being capable of early detection cell metabolism
Variation, suitable for the physical examination screening of large-scale crowd, the early diagnosis for being conducive to slow disease is early controlled.
Claims (8)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910179479.2A CN109793501A (en) | 2019-03-08 | 2019-03-08 | A non-invasive detection device for human metabolic health index |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910179479.2A CN109793501A (en) | 2019-03-08 | 2019-03-08 | A non-invasive detection device for human metabolic health index |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109793501A true CN109793501A (en) | 2019-05-24 |
Family
ID=66561768
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910179479.2A Pending CN109793501A (en) | 2019-03-08 | 2019-03-08 | A non-invasive detection device for human metabolic health index |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109793501A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110376177A (en) * | 2019-09-02 | 2019-10-25 | 武汉格谱光电科技有限公司 | Nicotinamide adenine dinucleotide fluorescence spectrum detecting device and application method |
| EP3861925A1 (en) * | 2020-02-05 | 2021-08-11 | Martin Herbst | Toilet seat with a device for detecting values and method of use thereof |
| CN115363574A (en) * | 2022-09-07 | 2022-11-22 | 瑞爱生医股份有限公司 | Optical detection system for triglyceride |
| JP7646176B2 (en) | 2020-09-28 | 2025-03-17 | 学校法人福岡大学 | Medical Fluorescence Equipment |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4541438A (en) * | 1983-06-02 | 1985-09-17 | The Johns Hopkins University | Localization of cancerous tissue by monitoring infrared fluorescence emitted by intravenously injected porphyrin tumor-specific markers excited by long wavelength light |
| CA2400309A1 (en) * | 2000-02-18 | 2001-08-23 | Argose,Inc. | Non-invasive tissue glucose level monitoring |
| JP2004290234A (en) * | 2003-03-25 | 2004-10-21 | Shiseido Co Ltd | Fluorescence measuring method for skin and apparatus therefor |
| US20070156037A1 (en) * | 2004-06-17 | 2007-07-05 | The Regents Of The University Of Californa | Time-resolved non-invasive optometric device for medical diagnostic |
| CN101716069A (en) * | 2009-11-17 | 2010-06-02 | 中国科学院安徽光学精密机械研究所 | Human body oxidative stress non-invasive fluorescence detection device and method |
| CN102697510A (en) * | 2003-10-28 | 2012-10-03 | 薇拉莱特公司 | Determination of a measure of a glycation end-product or disease state using tissue fluorescence |
| JP2014010076A (en) * | 2012-06-29 | 2014-01-20 | A-Kit Kk | Measurement device for advanced glycation end product |
| JP2015062572A (en) * | 2013-09-25 | 2015-04-09 | シャープ株式会社 | Skin state measuring method and skin state measuring device |
| CN105358947A (en) * | 2013-02-14 | 2016-02-24 | 曾海山 | Integrated spectral probe for raman, reflectance and fluorescence spectral measurements |
| CN210300954U (en) * | 2019-03-08 | 2020-04-14 | 合肥中科易康达生物医学有限公司 | Noninvasive human body metabolic health index detection equipment |
-
2019
- 2019-03-08 CN CN201910179479.2A patent/CN109793501A/en active Pending
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4541438A (en) * | 1983-06-02 | 1985-09-17 | The Johns Hopkins University | Localization of cancerous tissue by monitoring infrared fluorescence emitted by intravenously injected porphyrin tumor-specific markers excited by long wavelength light |
| CA2400309A1 (en) * | 2000-02-18 | 2001-08-23 | Argose,Inc. | Non-invasive tissue glucose level monitoring |
| JP2004290234A (en) * | 2003-03-25 | 2004-10-21 | Shiseido Co Ltd | Fluorescence measuring method for skin and apparatus therefor |
| CN102697510A (en) * | 2003-10-28 | 2012-10-03 | 薇拉莱特公司 | Determination of a measure of a glycation end-product or disease state using tissue fluorescence |
| US20070156037A1 (en) * | 2004-06-17 | 2007-07-05 | The Regents Of The University Of Californa | Time-resolved non-invasive optometric device for medical diagnostic |
| CN101716069A (en) * | 2009-11-17 | 2010-06-02 | 中国科学院安徽光学精密机械研究所 | Human body oxidative stress non-invasive fluorescence detection device and method |
| JP2014010076A (en) * | 2012-06-29 | 2014-01-20 | A-Kit Kk | Measurement device for advanced glycation end product |
| CN105358947A (en) * | 2013-02-14 | 2016-02-24 | 曾海山 | Integrated spectral probe for raman, reflectance and fluorescence spectral measurements |
| JP2015062572A (en) * | 2013-09-25 | 2015-04-09 | シャープ株式会社 | Skin state measuring method and skin state measuring device |
| CN210300954U (en) * | 2019-03-08 | 2020-04-14 | 合肥中科易康达生物医学有限公司 | Noninvasive human body metabolic health index detection equipment |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110376177A (en) * | 2019-09-02 | 2019-10-25 | 武汉格谱光电科技有限公司 | Nicotinamide adenine dinucleotide fluorescence spectrum detecting device and application method |
| EP3861925A1 (en) * | 2020-02-05 | 2021-08-11 | Martin Herbst | Toilet seat with a device for detecting values and method of use thereof |
| WO2021156117A1 (en) * | 2020-02-05 | 2021-08-12 | Martin Herbst | Seat ring comprising a device for acquiring values |
| JP2022550484A (en) * | 2020-02-05 | 2022-12-01 | マルティン ヘルプスト， | Toilet seat with device for detecting value |
| JP7477071B2 (en) | 2020-02-05 | 2024-05-01 | マルティン ヘルプスト， | Toilet seat with device for detecting values, system and method |
| JP7646176B2 (en) | 2020-09-28 | 2025-03-17 | 学校法人福岡大学 | Medical Fluorescence Equipment |
| CN115363574A (en) * | 2022-09-07 | 2022-11-22 | 瑞爱生医股份有限公司 | Optical detection system for triglyceride |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN109793501A (en) | A non-invasive detection device for human metabolic health index | |
| CN105358947B (en) | Integration spectrum for Raman, reflection and fluorescence spectral measuring is popped one's head in | |
| JP3643842B2 (en) | Glucose concentration testing device | |
| US6741876B1 (en) | Method for determination of analytes using NIR, adjacent visible spectrum and discrete NIR wavelenths | |
| CN101716069A (en) | Human body oxidative stress non-invasive fluorescence detection device and method | |
| US8306594B2 (en) | Transmission fluorometer | |
| CN101194828B (en) | Nondestructive optics detecting device for Eye aqueous glucose concentration | |
| JP2003315259A (en) | Tissue chromophore measurement system | |
| CA2383725A1 (en) | Method for determination of analytes using nir, adjacent visible spectrum and discrete nir wavelengths | |
| JPH1170101A (en) | Analysis method for blood component density, device therefor and optical fiber bundle for the device | |
| KR101097399B1 (en) | Disease diagnosis device by evaluation of final glycation product amount using skin autofluorescence | |
| KR970700859A (en) | NON-INVASIVE NON-SPECTROPHOTOMETRIC INFRARED MEASUREMENT OF BLOOD ANALYTE CONCENTRATIONS | |
| CA2383727A1 (en) | Method for determination of analytes using near infrared, adjacent visible spectrum and an array of longer near infrared wavelengths | |
| CN103635131A (en) | An apparatus for optical analysis of an associated tissue sample | |
| CN103565410B (en) | For the transmitted light detection type measurement device of skin autofluorescence | |
| JP2013195433A (en) | Reflected light detection type dermofluorometer | |
| EP2274594A2 (en) | Systems and methods for performing optical spectroscopy using a self-calibrating fiber optic probe | |
| CN210300954U (en) | Noninvasive human body metabolic health index detection equipment | |
| CN103536275A (en) | Reflection detection measurement device for skin autofluorescence | |
| US9888855B2 (en) | Reflection detection type measurement apparatus and method for skin autofluorescence | |
| CN201042433Y (en) | Living body tissue optical detector | |
| US20150201840A1 (en) | Reflection detection type measurement apparatus for skin autofluorescence | |
| CN203303031U (en) | Diabetes non-invasive detecting device based on glycation end product fluorescence spectrum | |
| CN103245650B (en) | Noninvasive diabetes detection device based on advanced glycation end product fluorescence spectrum | |
| CN108780041B (en) | Portable Optical Devices for Diffuse Reflectance Spectroscopy |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20190524 |