CN109781803A - A kind of blood glucose monitor - Google Patents
A kind of blood glucose monitor Download PDFInfo
- Publication number
- CN109781803A CN109781803A CN201711104413.4A CN201711104413A CN109781803A CN 109781803 A CN109781803 A CN 109781803A CN 201711104413 A CN201711104413 A CN 201711104413A CN 109781803 A CN109781803 A CN 109781803A
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- electrode
- data
- auxiliary
- contact
- blood sugar
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- 239000008280 blood Substances 0.000 title claims abstract description 25
- 210000004369 blood Anatomy 0.000 title claims abstract description 25
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 title claims abstract description 10
- 239000008103 glucose Substances 0.000 title claims abstract description 10
- 238000001514 detection method Methods 0.000 claims abstract description 21
- 108010015776 Glucose oxidase Proteins 0.000 claims abstract description 16
- 239000004366 Glucose oxidase Substances 0.000 claims abstract description 16
- 229940116332 glucose oxidase Drugs 0.000 claims abstract description 16
- 235000019420 glucose oxidase Nutrition 0.000 claims abstract description 16
- 238000000034 method Methods 0.000 claims abstract description 12
- 230000011664 signaling Effects 0.000 claims abstract description 12
- 239000000758 substrate Substances 0.000 claims abstract description 12
- 230000008569 process Effects 0.000 claims abstract description 8
- 239000012528 membrane Substances 0.000 claims description 5
- 229910010293 ceramic material Inorganic materials 0.000 claims description 3
- 238000005530 etching Methods 0.000 claims description 3
- 239000007769 metal material Substances 0.000 claims description 3
- 230000001681 protective effect Effects 0.000 claims description 3
- 230000005540 biological transmission Effects 0.000 abstract description 4
- 239000000126 substance Substances 0.000 description 9
- 238000005516 engineering process Methods 0.000 description 7
- 230000006870 function Effects 0.000 description 6
- 239000012620 biological material Substances 0.000 description 4
- 230000008859 change Effects 0.000 description 4
- 108090000790 Enzymes Proteins 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 229940088598 enzyme Drugs 0.000 description 3
- 238000004377 microelectronic Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000000427 antigen Substances 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 108020004414 DNA Proteins 0.000 description 1
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- -1 antibody Proteins 0.000 description 1
- 238000010923 batch production Methods 0.000 description 1
- 238000005842 biochemical reaction Methods 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000005518 electrochemistry Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 238000009413 insulation Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 210000003463 organelle Anatomy 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000008447 perception Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000012958 reprocessing Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000002463 transducing effect Effects 0.000 description 1
Landscapes
- Investigating Or Analysing Biological Materials (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
The present invention provides a kind of blood glucose monitors, including blood sugar biosensor, the blood sugar biosensor is connected with the data source of a transmission blood sugar biosensor detection data, data source is correspondingly arranged on one and receives and processes the data sink that the data source sends data, data sink is connected with display screen, data sink is connected with headend by wireless telecommunications, headend is connected with remote display, wherein, the blood sugar biosensor includes die substrate, and it is formed in the detecting electrode on the die substrate, auxiliary electrode, multiple glucose oxidase fixed areas, repeater electrode, auxiliary signal contact, detect signalling contact, it also include a plurality of connection line.The patient monitor can facilitate detection, and detection accuracy is higher.
Description
Technical field
The present invention relates to blood sugar for human body measurement and display fields.
Background technique
There are two types of units for blood glucose value representation, and it to be old system unit that one is milligram/decilitre (mg/dl)；Another kind is mmoles
You/liter (mmol/L), it is brand-new unit.Though existing advocate uses brand-new unit, old system unit is still used in a certain range.So
Know therebetween how to convert it is just very necessary.The reduction formula of two kinds of units are as follows: mg/dl ÷ 18=mmol/L；mmol/L
× 18=mg/dl.Such as: it, need to be divided by 18, i.e. 120mg/dl ÷ 18 when 120mg/dl is converted into the numerical value as unit of mmol/L
=6.67mmol/L；It, need to be multiplied by 18, i.e. 6.67mmol/L × 18 when 6.67mmol/L is converted into the numerical value as unit of mg/dl
=120mg/dl.
Biosensor is made of molecular recognition part (sensing element) and conversion portion (energy converter):
Identification measured target is removed with molecular recognition part, is the main function that can cause certain physical change or chemical change
It can element.Molecular recognition part is the basis that biosensor selectively measures.
The signal that bioactivity is expressed is converted to the physically or chemically energy converter (sensor) of electric signal
Various biosensors have following common structure: including one or several kinds of relevant biological activity materials (biomembrane)
And the signal that bioactivity is expressed can be converted to the physically or chemically energy converter (sensor) of electric signal, the two is combined one
It rises, the reprocessing of bio signal is carried out with modern microelectronic and automation instrument technology, constitute the various biologies that can be used and pass
Sensor analytical equipment, instrument and system.
Biosensor realizes following three functions:
Impression: extract animals and plants play perception effect biomaterial, comprising: biological tissue, microorganism, organelle,
Enzyme, antibody, antigen, nucleic acid, DNA etc..The batch production for realizing biomaterial or class biomaterial, is recycled, and reduces detection
Difficulty and cost.
Observation: by biomaterial experience continue, regular information is converted to one will understand that information.
Reaction: showing people by modes such as optics, piezoelectricity, electrochemistry, temperature, electromagnetism for information, is determining for people
Plan provides foundation.
Biosensor has the function of recipient and converter.It is sensitive to biological substance and its concentration is converted into telecommunications
Number instrument detected.
Can selectively be offered an explanation in organism predetermined substance substance have enzyme,
Antibody, tissue, cell etc..These molecular recognition function substances can be combined into multiple by identification process with measured target
Close object, such as the combination of antibody and antigen, the combination of enzyme and matrix.
When designing biosensor, it is particularly important premise that selection, which is suitable for the identification function substance of measure object,.
To consider the characteristic of generated compound.Chemistry caused by the sensing element prepared according to molecular recognition function substance becomes
Selection energy converter is removed in change or physical change, is another important link for developing high quality biosensor.Light in sensing element,
Heat, the generation of chemical substance or consumption etc. can generate corresponding variable quantity.According to these variable quantities, transducing appropriate can choose
Device.
The information that biochemical reaction process generates is diversification, and the achievement of microelectronics and Modern Transducer Technology has been
It detects these information and provides means abundant.
Biosensor is one and is interpenetrated growth by a variety of subjects such as biology, chemistry, physics, medicine, electronic technology
The new and high technology got up.Because its have the good, high sensitivity of selectivity, analysis speed it is fast, it is at low cost, carry out in complicated system
On-line continuous monitoring, especially the increasingly automated of it, micromation and integrated feature obtain it in recent decades flourishing
And rapidly develop.
National economy each department for example food, pharmacy, chemical industry, clinical examination, biomedicine, in terms of
Have wide practical use.Especially molecular biology and microelectronics, photoelectronics, micrometer-nanometer processing technology and nanotechnology etc.
New disciplines, new technology combine, and are just changing the looks of traditional medicine, environmental science zoology and botany.The research of biosensor is opened
Hair, it has also become the new hot spot of development in science and technology of world forms the important component of 21 century emerging high-tech industry, has weight
The strategic importance wanted.
Summary of the invention
The present invention provides a kind of blood glucose monitor, including blood sugar biosensor, the blood sugar biosensor connection
There is the data source of a transmission blood sugar biosensor detection data, data source is correspondingly arranged on one and receives and processes this
Data source sends the data sink of data, and data sink is connected with display screen, and data sink passes through wireless telecommunications
It is connected with headend, headend is connected with remote display, wherein the blood sugar biosensor includes chip bottom
Plate, and the detecting electrode, auxiliary electrode, the multiple glucose oxidase fixed areas, middle relay that are formed on the die substrate
Pole, auxiliary signal contact, detection signalling contact, also include a plurality of connection line, the glucose oxidase fixed area is set respectively
It sets between detecting electrode and auxiliary electrode and repeater electrode, the detecting electrode, auxiliary electrode pass through the connecting line respectively
Road is electrically connected with auxiliary signal contact, detection signalling contact.
Preferably, the die substrate is the substrate of ceramic material, processes to be formed by etching method.
Preferably, the glucose oxidase fixed area has protection permeable membrane.
Preferably, the auxiliary signal contact, detection signalling contact are metal material contact.
Preferably, the detecting electrode, auxiliary electrode, repeater electrode and auxiliary signal contact, detection signalling contact among
Connection line surface cover insulating protective film, to improve insulation characterisitic.
Electrode sensor chip of the invention facilitates detection, and detection accuracy is higher.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of one embodiment of the invention.
Appended drawing reference:
1, die substrate
2, detecting electrode
3, auxiliary electrode
4, glucose oxidase fixed area
5, repeater electrode
6, auxiliary signal contact
7, signalling contact is detected
Specific embodiment
To further illustrate the technical scheme of the present invention below with reference to the accompanying drawings and specific embodiments.It is understood that
It is that described herein the specific embodiments are only for explaining the present invention, rather than limitation of the invention.Further need exist for explanation
It is, for ease of description, only some but not all contents related to the present invention are shown in the drawings.
In conjunction with Fig. 1, a kind of blood glucose monitor, including blood sugar biosensor are provided, the blood sugar biosensor connects
It is connected to the data source of a transmission blood sugar biosensor detection data, data source is correspondingly arranged on one and receives and processes
The data source sends the data sink of data, and data sink is connected with display screen, and data sink passes through channel radio
News are connected with headend, and headend is connected with remote display, wherein blood sugar biosensor includes die substrate
1, it is the substrate of ceramic material, processes die substrate 1, detecting electrode 2, auxiliary electrode 3, middle relay using etching method on it
Pole 5,6 component of auxiliary signal contact and connection line.Then between detecting electrode 2, auxiliary electrode 3,5 electrode of repeater electrode
Fixing belt protects the glucose oxidase fixed area 4 for having bioactivity of permeable membrane, auxiliary signal contact 6, detection signal touching
Electric signal obtained is transferred to the analysis circuit of instrument by the metal parts being in contact with it for metal material contact by point 7
In.Detecting electrode 2, auxiliary electrode 3, repeater electrode 5 and the line surface among auxiliary signal contact 6, detection signalling contact 7 are equal
Insulating protective film is covered, to prevent electric signal from losing or decaying.
When work, inspected blood sample or the sample droplets after diluting are seeped in glucose oxidase fixed area 4 with protection
Permeable membrane has at the glucose oxidase of bioactivity, contained glucose (C in examined samples6H12O6) macromolecular transmission infiltration
Permeable membrane reacts with internal glucose oxidase (GOD), is generated glucose after glucose oxidase (GOD) oxidation
Acid (C6H12O7) and hydrogen peroxide (H2O2) two kinds of compositions, the variation of composition will affect its conductivity, and according to reacted institute
Both compositions generated contain numerical quantity difference, and the electron number exchanged between 2 liang of auxiliary electrode 3, detecting electrode electrodes also will
Difference will generate different electric signals.Detected electric signal is passed through detection signalling contact by conducting wire by detecting electrode 2
7 are transferred in the analysis circuit of instrument internal, and after calculating, can be obtained the glucose in examined samples contains numerical quantity.
The foregoing is merely a prefered embodiment of the invention, is not intended to limit the invention, all in the spirit and principles in the present invention
Within, any modification, equivalent replacement, improvement and so on should all be included in the protection scope of the present invention.
Claims (5)
1. a kind of blood glucose monitor, it is characterised in that: including blood sugar biosensor, the blood sugar biosensor is connected with one
The data source of blood sugar biosensor detection data is sent, data source is correspondingly arranged on one and receives and processes the data
Transmitter sends the data sink of data, and data sink is connected with display screen, and data sink is connected by wireless telecommunications
There is headend, headend is connected with remote display, wherein the blood sugar biosensor includes die substrate,
And be formed in detecting electrode on the die substrate, auxiliary electrode, multiple glucose oxidase fixed areas, repeater electrode,
Auxiliary signal contact, detection signalling contact, also include a plurality of connection line, the glucose oxidase fixed area is separately positioned on
Between detecting electrode and auxiliary electrode and repeater electrode, the detecting electrode, auxiliary electrode respectively by the connection line with
Auxiliary signal contact, detection signalling contact electrical connection.
2. electrode sensor chip as described in claim 1, it is characterised in that: the die substrate is the base of ceramic material
Plate is processed to form detecting electrode, auxiliary electrode, multiple glucose oxidase fixed areas, repeater electrode, auxiliary letter by etching method
Number contact, detection signalling contact and a plurality of connection line.
3. electrode sensor chip as described in claim 1, it is characterised in that: the glucose oxidase fixed area, which has, to be protected
Protect permeable membrane.
4. electrode sensor chip as described in claim 1, it is characterised in that: the auxiliary signal contact, detection signal touching
Point is metal material contact.
5. electrode sensor chip as described in claim 1, it is characterised in that: the detecting electrode, auxiliary electrode, middle relay
Connection line surface among pole and auxiliary signal contact, detection signalling contact covers insulating protective film.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711104413.4A CN109781803B (en) | 2017-11-10 | 2017-11-10 | Blood glucose monitor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711104413.4A CN109781803B (en) | 2017-11-10 | 2017-11-10 | Blood glucose monitor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109781803A true CN109781803A (en) | 2019-05-21 |
| CN109781803B CN109781803B (en) | 2024-01-26 |
Family
ID=66484865
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711104413.4A Active CN109781803B (en) | 2017-11-10 | 2017-11-10 | Blood glucose monitor |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109781803B (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1373361A (en) * | 2002-04-11 | 2002-10-09 | 复旦大学 | Expandable electrode for measuring blood sugar and its preparing process |
| US20050272989A1 (en) * | 2004-06-04 | 2005-12-08 | Medtronic Minimed, Inc. | Analyte sensors and methods for making and using them |
| CN101929977A (en) * | 2010-08-31 | 2010-12-29 | 刘丹 | Enzyme bioelectrochemical sensing chip and preparation and using methods thereof |
| CN102121914A (en) * | 2010-01-11 | 2011-07-13 | 明志科技大学 | Electrochemical power supply method and device |
| CN106770542A (en) * | 2016-11-25 | 2017-05-31 | 深圳大学 | A kind of noninvasive dynamics monitoring test paper and preparation method thereof |
-
2017
- 2017-11-10 CN CN201711104413.4A patent/CN109781803B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1373361A (en) * | 2002-04-11 | 2002-10-09 | 复旦大学 | Expandable electrode for measuring blood sugar and its preparing process |
| US20050272989A1 (en) * | 2004-06-04 | 2005-12-08 | Medtronic Minimed, Inc. | Analyte sensors and methods for making and using them |
| CN102121914A (en) * | 2010-01-11 | 2011-07-13 | 明志科技大学 | Electrochemical power supply method and device |
| CN101929977A (en) * | 2010-08-31 | 2010-12-29 | 刘丹 | Enzyme bioelectrochemical sensing chip and preparation and using methods thereof |
| CN106770542A (en) * | 2016-11-25 | 2017-05-31 | 深圳大学 | A kind of noninvasive dynamics monitoring test paper and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN109781803B (en) | 2024-01-26 |
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Denomination of invention: A blood glucose monitor Granted publication date: 20240126 Pledgee: Shanghai Rural Commercial Bank Co.,Ltd. Pudong branch Pledgor: SHANGHAI HILEAP MEDICAL TECHNOLOGY Co.,Ltd. Registration number: Y2024310000741 |