CN109758553A - A kind of external medicine composition and preparation method thereof for treating gout - Google Patents
A kind of external medicine composition and preparation method thereof for treating gout Download PDFInfo
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Abstract
The effect of present invention provides a kind of external medicine composition for treating gout, and the composition is played a role using the compatibility relationship collaboration of monarch, monarch drug in a prescription activating microcirculation and removing stasis medicinal, wind-expelling pain-stopping, line water detumescence, reaches quick swelling and pain relieving for swelling and pain caused by gout；Ministerial drug is clearing heat and detoxicating, purging intense heat heat dissipation, swelling and pain relieving；On the one hand ministerial drug reinforces the effect of monarch drug in a prescription swelling and pain relieving, on the other hand carry out for the accompanying symptoms of gout clearing heat and detoxicating；The monarch and his subjects' compatibility, swelling and pain relieving quickly mitigate patient suffering；Adjutant dispelling wind and eliminating dampness is removed obstruction in channels to relieve pain；The effect of adjutant is supplementary drug, and cooperation monarch, ministerial drug are to reinforce wind-dispelling swelling and pain relieving；So that efficacy-enhancing ingredient medicine is gone directly affected part, and infiltrates through fascia；The effect of all medicine compatibilities, play removing damp-heat altogether, and turbid, swelling and pain relieving is let out in relaxing tendons and activating collaterals, tonneau passages through which vital energy circulates, dampness removing, part congestion and swelling pain caused by rapid recovery gout.
Description
Technical field
The invention belongs to tcm fields, and in particular to a kind of external medicine composition for treating gout and its preparation side
Method.
Background technique
With the continuous improvement of national life level, huge change is had occurred in the dietary structure of people.Now some
Like plenty of meat and fish, overeating leads to overnutrition, therefore fat people is more and more, and the number for the patient that divulges information also exists
It rises year by year.Gout is a kind of since biosynthesis of purine is metabolized increase, and uric acid is generated excessive or caused because uric acid excretion is bad
Uric acid increases in blood, and it is scorching that urate crystal is deposited in caused repeated relapsing in synovium of joint, synovial bursa, cartilage and its hetero-organization
Property disease.Arthralgia acute attack is the classical symptom of acute gout.Without obvious sign before the breaking-out of patient with gout majority, or only
There are tired, general malaise and joint sting etc., Typical onset is often waken up with a start in the late into the night because of arthralgia, the aggravation of pain progressive,
It peaked at 12 hours or so, bites sample in tearing sample, cut sample or stinging, it is difficult to endure.Affected joints and surrounding tissue it is red,
Swollen, heat, pain and function limitation.Gout is a kind of lifelong disease, and absent renal function damage or joint deformity person are by effectively treatment
Normal life and work can be generally maintained, more will not influence the service life.But if malpractice, the recurrent exerbation of acute arthritis
It can cause biggish pain.In the prior art for the treatment of gout mainly using the synthesis of inhibition uric acid, promotion uric acid excretion, suppression
The means such as inflammation processed, the treatment of gout acute attack mainly use colchicin, and chronic gout mainly uses Allopurinol to reduce
The content of uric acid in blood, although these efficacy of drugs are effectively, but toxic side effect is larger.Make currently on the market for pain
External drug includes Yunnan Baiyao spray, ZHENGHONGHUA YOU and HUOLUO YOU etc., and the drug of these treatment trauma pains is simultaneously
It is not suitable for treating gout, therefore for the symptom of gout morbidity, researches and develops the pain symptom of rapid recovery gout, mitigates patient's pain
Bitter topical agent is imperative.
Summary of the invention
For the technical problem more than solving, the present invention provide one kind can pain caused by rapid recovery gout, effectively
The external medicine composition and preparation method thereof for treating acute gouty arthritis.
The object of the present invention is to provide a kind of external medicine compositions for treating acute gout.
It is a further object of the present invention to provide a kind of preparation methods of the external medicine composition of above-mentioned treatment gout.
The external medicine composition of the treatment gout of specific embodiment according to the present invention, the original including following parts by weight
Material:
A group: 30~50 parts of red ant, 30~50 parts of silky ant, 60~80 parts of caulis piperis futokadsurae, 50~80 parts of philippine flemingia root, slender acanthopanax
60~80 parts of skin, 50~80 parts of centella, 60~90 parts of Herba Polygoni Runcinati, 60~90 parts of drilling wind；
B group: 30~50 parts of safflower, 50~80 parts of lopseed, 60~90 parts of the root of Chinese clematis, 60~90 parts of glaucescent fissistigma root, two sides
50~80 parts of needle, 50~80 parts of erythrina bark, 60~90 parts of stauntonvine, 60~90 parts of sweetberry jointfir；
C group: 60~80 parts of decumbent corydalis tuber, 60~80 parts of spinyleaf pricklyash root, 60~90 parts of see swelling, 50~80 parts of I. henry Diels, salt skin
Wooden 60~90 parts, 60~90 parts of jobstears root, 50~80 parts of Pterospermi Heterophylli, 60~90 parts of rhizoma dioscoreae nipponicae；
D group: 50~80 parts of rhizoma atractylodis, 60~80 parts of radix achyranthis bidentatae, 50~80 parts of Cortex Phellodendri, 60~90 parts of Herba Lycopi, 60~80 parts of rheum officinale,
60~90 parts of cape jasmine, 50~70 parts of Radix Salviae Miltiorrhizae, 50~80 parts of gentianae macrophyllae, 50~80 parts of Radix Angelicae Pubescentis, 50~80 parts of bush, peppermint 30~50
Part, 60~90 parts of ramulus mori.
Preferably, the external medicine composition of the treatment gout, the raw material including following parts by weight:
A group: 35~45 parts of red ant, 35~45 parts of silky ant, 65~75 parts of caulis piperis futokadsurae, 60~70 parts of philippine flemingia root, slender acanthopanax
65~75 parts of skin, 60~70 parts of centella, 70~80 parts of Herba Polygoni Runcinati, 70~80 parts of drilling wind；
B group: 35~45 parts of safflower, 60~70 parts of lopseed, 70~80 parts of the root of Chinese clematis, 70~80 parts of glaucescent fissistigma root, two sides
60~70 parts of needle, 60~70 parts of erythrina bark, 70~80 parts of stauntonvine, 70~80 parts of sweetberry jointfir；
C group: 65~75 parts of decumbent corydalis tuber, 65~75 parts of spinyleaf pricklyash root, 70~80 parts of see swelling, 60~70 parts of I. henry Diels, salt skin
Wooden 70~80 parts, 70~80 parts of jobstears root, 60~70 parts of Pterospermi Heterophylli, 70~80 parts of rhizoma dioscoreae nipponicae；
D group: 60~70 parts of rhizoma atractylodis, 65~75 parts of radix achyranthis bidentatae, 60~70 parts of Cortex Phellodendri, 70~80 parts of Herba Lycopi, 65~75 parts of rheum officinale,
70~80 parts of cape jasmine, 55~65 parts of Radix Salviae Miltiorrhizae, 60~70 parts of gentianae macrophyllae, 60~70 parts of Radix Angelicae Pubescentis, 60~70 parts of bush, peppermint 35~45
Part, 70~80 parts of ramulus mori.
Preferably, the external medicine composition of the treatment gout, the raw material including following parts by weight:
A group: 40 parts of red ant, 40 parts of silky ant, 70 parts of caulis piperis futokadsurae, 65 parts of philippine flemingia root, 70 parts of cortex acanthopanacis, centella 65
Part, 75 parts of Herba Polygoni Runcinati, 75 parts of drilling wind；
B group: 40 parts of safflower, 65 parts of lopseed, 75 parts of the root of Chinese clematis, 75 parts of glaucescent fissistigma root, 65 parts of Radix zanthoxyli, erythrina bark 65
Part, 75 parts of stauntonvine, 75 parts of sweetberry jointfir；
C group: 70 parts of decumbent corydalis tuber, 70 parts of spinyleaf pricklyash root, 75 parts of see swelling, 65 parts of I. henry Diels, 75 parts of Chinese sumac, jobstears root 75
Part, 65 parts of Pterospermi Heterophylli, 75 parts of rhizoma dioscoreae nipponicae；
D group: 65 parts of rhizoma atractylodis, 70 parts of radix achyranthis bidentatae, 65 parts of Cortex Phellodendri, 75 parts of Herba Lycopi, 70 parts of rheum officinale, 75 parts of cape jasmine, 60 parts of Radix Salviae Miltiorrhizae, the Qin
65 parts of Macrophylla, 65 parts of Radix Angelicae Pubescentis, 65 parts of bush, 40 parts of peppermint, 75 parts of ramulus mori.
The present invention is sent out according to the clinical manifestation of gout for hyperuricemia and its urarthritis of initiation repeatedly
Make, tophaceous chornic arthritis, using Xiezhuo Huayu, the method for tonneau passages through which vital energy circulates is subject to clearing and activating the channels and collaterals, the reason of relaxing tendons and activating collaterals
It reads, pain caused by gout is effectively relieved.Gout causes unbearably to swell and ache, and pain belongs to fire, swells and belongs to wet, the present invention is with red ant, black ant
Ant, safflower, I. henry Diels, philippine flemingia root, cortex acanthopanacis, sweetberry jointfir, decumbent corydalis tuber, Herba Lycopi, Radix Salviae Miltiorrhizae, spinyleaf pricklyash root, bush are monarch drug in a prescription, red ant
Ant contains formic acid, alkaloid and histamine, has effects that analgesia, has good curative effect to rheumatism；Silky ant improves human body and exempts from
Epidemic disease power, calm, tranquilizing the mind, also has good therapeutic effect to rheumatism；Red ant and silky ant share, and have and strengthen the body resistance to consolidate the constitution, grow
The effect of nourishing liver and kidney, eliminating blood stasis and smoothing collaterals；Safflower, I. henry Diels, decumbent corydalis tuber, Herba Lycopi, Radix Salviae Miltiorrhizae share activating microcirculation and removing stasis medicinal, removing pattogenic heat from the blood and toxic material from the body, dispel
Wind and removing obstruction in channels, promoting qi circulation and relieving pain, line water detumescence；Philippine flemingia root, cortex acanthopanacis wind-damp dispelling, strong waist and knee；Spinyleaf pricklyash root, bush dispelling wind and eliminating dampness, middle benefit gas
Qi-regulating；The effect of monarch drug in a prescription shares, and collaboration reaches activating microcirculation and removing stasis medicinal, wind-expelling pain-stopping, line water detumescence, monarch drug in a prescription is for swelling and pain caused by gout
The effect of reaching quick swelling and pain relieving；The present invention is with the root of Chinese clematis, see swelling, Radix zanthoxyli, centella, rheum officinale, cape jasmine, Cortex Phellodendri, thin
Lotus is ministerial drug, and the root of Chinese clematis is apt to walk suddenly, the key medicine of degrading the channel；See swelling, centella, rheum officinale, cape jasmine clearing heat and promoting diuresis；Cortex Phellodendri heat-clearing
Eliminating dampness, purging intense heat, except steaming；Peppermint dispelling wind-heat, refresh oneself；Ministerial drug is clearing heat and detoxicating, purging intense heat heat dissipation, swelling and pain relieving；On the one hand ministerial drug adds
On the other hand the effect of strong monarch drug in a prescription swelling and pain relieving carries out clearing heat and detoxicating for the accompanying symptoms of gout；The monarch and his subjects' compatibility, quickly detumescence stops
Bitterly, mitigate patient suffering；The present invention with glaucescent fissistigma root, Herba Polygoni Runcinati, erythrina bark, caulis piperis futokadsurae, stauntonvine, Pterospermi Heterophylli, jobstears root, solely
Work, gentianae macrophyllae, Chinese sumac, rhizoma atractylodis are adjutant, and adjutant dispelling wind and eliminating dampness is removed obstruction in channels to relieve pain；The adjutant is supplementary drug, cooperates monarch, ministerial drug
The effect of to reinforce wind-dispelling swelling and pain relieving；The present invention is to make medicine with drilling wind, lopseed, rhizoma dioscoreae nipponicae, ramulus mori, radix achyranthis bidentatae, makes efficacy-enhancing ingredient
Medicine goes directly affected part, and infiltrates through fascia；All medicine compatibilities, play removing damp-heat altogether, and relaxing tendons and activating collaterals, tonneau passages through which vital energy circulates, dampness removing let out turbid, detumescence
Analgesic, it is nourishing liver and kidney, the effect of promoting uric acid excretion, reduce uric acid deposition, part congestion and swelling pain caused by rapid recovery gout.
Chinese medicine composition provided by the invention is shared by all herbal medicines of monarch, promotes therapeutic effect, controls progression of the disease, to pain
Wind has good therapeutic effect, and toxic side effect is small.
In order to make it easy to understand, the present invention provides the effect of part material medicinal material.
Herba Polygoni Runcinati: slight bitter is put down；Major function: wind-dispelling is detoxified, symplectic bone myogenic.Treat treating rheumatic ostealgia, lumbago due to the kidney deficiency, bruise
Damage.
Glaucescent fissistigma root, it is bitter, cold；Major function is clearing heat and detoxicating, anti-inflammatory analgetic.Function with wind-damp dispelling, clearing and activating the channels and collaterals, hemostasis
Effect.Modern study, glaucescent fissistigma root also have antitumor action.
Stauntonvine: nature and flavor are sweet, warm-natured；Return heart, kidney channel；Major function ventilation active, promoting blood circulation and stopping pain, inducing diuresis to remove edema.Main wind
Arthritis with fixed pain caused by dampness pain.
Decumbent corydalis tuber: bitter, pungent, cool；Channel tropism liver and kidney channel；Major function dispelling wind and eliminating dampness relaxing tendons and activating collaterals, removes obstruction in channels to relieve pain, drops blood
Pressure.Main rheumatic arthritis；Hemiplegia；Sciatica；Lumbar muscle strain；Injury from falling down；Hypertension.
Spinyleaf pricklyash root: pungent, warm；Major function: dispelling wind and eliminating dampness, middle benefit gas qi-regulating, removing blood stasis and acesodyne.For pain in rheumatoid joints, fall
Beat damage, bruise.
Centella, bitter, acrid, cold；Liver,spleen,kidney is returned to pass through；Major function: clearing heat and promoting diuresis, removing toxicity for detumescence.
See swelling, sour and astringent, micro- poison, detoxicating and resolving a mass, swelling and pain relieving.Suitable for carbuncle sore tumefacting virus.
Chinese sumac: sour, salty, cold, major function is clearing heat and detoxicating, dissipating stasis and stanching bleeding.
Jobstears root, reducing fever and causing diuresis, invigorating the spleen excreting dampness, clearing away heat and eliminating pus, for arthritis with fixed pain caused by dampness muscular constricture, the disease of retention of damp-heat in the interior.
Pterospermi Heterophylli, it is sweet, warm；Major function dispelling wind and eliminating dampness, relaxing tendons and activating collaterals；For rheumatic arthritis, rheumatoid joint
Inflammation, lumbar muscle strain, chronic lumbocrural pain.
Rhizoma dioscoreae nipponicae, it is bitter, flat；Major function: relaxing tendons and activating collaterals, dispelling wind and eliminating dampness；For Bi condition, traumatic injury.
Herba Lycopi, bitter, pungent, tepor；Return liver, the spleen channel；Major function: activating microcirculation and removing stasis medicinal, line water detumescence.Abdominal mass is treated, falls and flutters damage
Wound.
Gentianae macrophyllae is pungent, bitter, flat；Return stomach, liver, gallbladder channel；Major function: wind-damp dispelling, clearing away damp-heat, stopping numbness pain；For rheumatism numbness
Bitterly, skeletal pain.
Bush, it is sweet, salty, flat；Return heart, liver, the spleen channel；Major function: promoting circulation of blood dissolving stasis, swelling and pain relieving；For chest and abdomen shouting pain, outside
Wound swelling and pain.
The preparation method of the external medicine composition of above-mentioned treatment gout, comprising the following steps:
(1) raw material is weighed according to parts by weight, be respectively dried, crushed, is sieved, mixing obtains raw material mixed powder；
(2) raw material mixed powder that step (1) obtains is added in alcoholic solution, impregnates 7~15 days, obtains the treatment
The Chinese medicine composition of gout.
The preparation method of the external medicine composition for the treatment of gout provided by the invention, by by raw medicinal material xeraphium
It is broken, drug mixed powder is obtained, then impregnates drug mixed powder in alcoholic solution, effective ingredient can be molten as far as possible
Out, Chinese medicine composition is promoted to the remission effect of pain caused by gout.Preparation method provided by the invention is easy to operate, maximum
The effective component of degree reservation drug.
Preferably, in step (1), the temperature of the drying is 50~65 DEG C, and drying time is 2~4h.
Preferably, in step (1), the drying is vacuum drying, and vacuum degree is -0.12~-0.05MPa.The present invention mentions
The furnace drying method of confession by medicine material carry out cryogenic vacuum drying, retain effective ingredient, avoid drying to drug effectively at
The a large amount of losses and destruction divided.
Preferably, in step (1), the partial size of the raw material mixed powder is 200~500 mesh.The granularity of medicinal material is theoretically
For be to crush more thinner better, still, in fact, during immersion, the too small obtained drug powder of partial size is simultaneously uncomfortable
Preferably leach.Partial size is too small, a large amount of cell ruptures in medicinal material tissue, and only intracellular a large amount of insoluble matters and invalid components leach, and increases
Add impurity.And partial size is excessive, the contact area of medicinal material and solvent is small, and solute effect is not good enough, and therefore, reasonable partial size is to improve medicine
The important influence factor of object effective component dissolution.It is studied by inventor, when the partial size of medicinal raw material is in 200~500 mesh,
Effective ingredient in raw material can be effectively dissolved in solvent, promote the amount of dissolution of effective ingredient.
Preferably, in step (2), the volume fraction of the alcoholic solution is 60~75%.
Preferably, in step (2), the weight ratio of the raw mixture and alcoholic solution is 1:3~6.
Preferably, in step (2), the raw material mixed powder that step (1) obtains is added in alcoholic solution, ultrasonic treatment 10
Then~20min impregnates 7~15 days.
The invention has the benefit that
The external medicine composition for the treatment of gout provided by the invention is according to the clinical manifestation of gout, for hyperuricemia
And its urarthritis recurrent exerbation, the tophaceous chornic arthritis of initiation, using Xiezhuo Huayu, the side of tonneau passages through which vital energy circulates
Method, is subject to clearing and activating the channels and collaterals, and pain caused by gout is effectively relieved in the theory of relaxing tendons and activating collaterals.Gout causes unbearably to swell and ache, and pain belongs to
Fire swells and belongs to wet, and the present invention is with red ant, silky ant, safflower, I. henry Diels, philippine flemingia root, cortex acanthopanacis, sweetberry jointfir, decumbent corydalis tuber, pool
Orchid, Radix Salviae Miltiorrhizae, spinyleaf pricklyash root, bush are monarch drug in a prescription, and red ant contains formic acid, alkaloid and histamine, has effects that analgesia, are had to rheumatism
There is good curative effect；Silky ant improves the immunity of the human body, and calm, tranquilizing the mind also has good therapeutic effect to rheumatism；Red ant
It is shared with silky ant, has effects that strengthen the body resistance to consolidate the constitution, nourishing liver and kidney, eliminating blood stasis and smoothing collaterals；Safflower, I. henry Diels, decumbent corydalis tuber, Herba Lycopi,
Radix Salviae Miltiorrhizae shares activating microcirculation and removing stasis medicinal, removing pattogenic heat from the blood and toxic material from the body, dispelling wind and removing obstruction in the meridians, promoting qi circulation and relieving pain, line water detumescence；Philippine flemingia root, cortex acanthopanacis wind-damp dispelling, strong waist
Knee；Spinyleaf pricklyash root, bush dispelling wind and eliminating dampness, middle benefit gas qi-regulating；Monarch drug in a prescription shares, and collaboration reaches activating microcirculation and removing stasis medicinal, wind-expelling pain-stopping, line water detumescence
The effect of effect, monarch drug in a prescription reaches quick swelling and pain relieving for swelling and pain caused by gout；The present invention is with the root of Chinese clematis, see swelling, two sides
Needle, centella, rheum officinale, cape jasmine, Cortex Phellodendri, peppermint are ministerial drug, and the root of Chinese clematis is apt to walk suddenly, the key medicine of degrading the channel；See swelling, accumulated snow
Grass, rheum officinale, cape jasmine clearing heat and promoting diuresis；Cortex Phellodendri heat-clearing and damp-drying drug, purging intense heat, except steaming；Peppermint dispelling wind-heat, refresh oneself；Ministerial drug is clearing heat and detoxicating,
Purging intense heat heat dissipation, swelling and pain relieving；On the one hand ministerial drug reinforces the effect of monarch drug in a prescription swelling and pain relieving, on the other hand carry out for the accompanying symptoms of gout
It is clearing heat and detoxicating；The monarch and his subjects' compatibility, quick swelling and pain relieving, mitigates patient suffering in time；The present invention with glaucescent fissistigma root, Herba Polygoni Runcinati, erythrina bark,
Caulis piperis futokadsurae, stauntonvine, Pterospermi Heterophylli, jobstears root, Radix Angelicae Pubescentis, gentianae macrophyllae, Chinese sumac, rhizoma atractylodis are adjutant, and adjutant dispelling wind and eliminating dampness, dredging collateral stop
Bitterly；The effect of adjutant is supplementary drug, and cooperation monarch, ministerial drug are to reinforce wind-dispelling swelling and pain relieving；The present invention is with drilling wind, deep
Grass, rhizoma dioscoreae nipponicae, ramulus mori, radix achyranthis bidentatae are to make medicine, so that efficacy-enhancing ingredient medicine is gone directly affected part, and infiltrate through fascia；All medicine compatibilities are played go down coke clearly altogether
The effect of heat dehumidifying, turbid, swelling and pain relieving is let out in relaxing tendons and activating collaterals, tonneau passages through which vital energy circulates, dampness removing, the red and swollen pain in part caused by rapid recovery gout
Bitterly.Chinese medicine composition provided by the invention is shared by all herbal medicines of monarch, promotes therapeutic effect, inhibits toxic side effect,
There is good therapeutic effect to gout, and toxic side effect is small.
Specific embodiment
To make the object, technical solutions and advantages of the present invention clearer, technical solution of the present invention will be carried out below
Detailed description.Obviously, described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.Base
Embodiment in the present invention, those of ordinary skill in the art are obtained all without making creative work
Other embodiment belongs to the range that the present invention is protected.
1 parts by weight in embodiment provided by the invention are 1g.
Embodiment 1
The external medicine composition for treating gout, the raw material including following parts by weight:
A group: 30 parts of red ant, 30 parts of silky ant, 60 parts of caulis piperis futokadsurae, 50 parts of philippine flemingia root, 60 parts of cortex acanthopanacis, centella 50
Part, 60 parts of Herba Polygoni Runcinati, 60 parts of drilling wind；
B group: 30 parts of safflower, 50 parts of lopseed, 60 parts of the root of Chinese clematis, 60 parts of glaucescent fissistigma root, 50 parts of Radix zanthoxyli, erythrina bark 50
Part, 60 parts of stauntonvine, 60 parts of sweetberry jointfir；
C group: 60 parts of decumbent corydalis tuber, 60 parts of spinyleaf pricklyash root, 60 parts of see swelling, 50 parts of I. henry Diels, 60 parts of Chinese sumac, jobstears root 60
Part, 50 parts of Pterospermi Heterophylli, 60 parts of rhizoma dioscoreae nipponicae；
D group: 50 parts of rhizoma atractylodis, 60 parts of radix achyranthis bidentatae, 50 parts of Cortex Phellodendri, 60 parts of Herba Lycopi, 60 parts of rheum officinale, 60 parts of cape jasmine, 50 parts of Radix Salviae Miltiorrhizae, the Qin
50 parts of Macrophylla, 50 parts of Radix Angelicae Pubescentis, 50 parts of bush, 30 parts of peppermint, 60 parts of ramulus mori.
The preparation method of the external medicine composition of above-mentioned treatment gout, comprising the following steps:
(1) raw material is weighed according to parts by weight, is respectively -0.12~-0.05MPa in vacuum degree, temperature is 50~55
DEG C drying 3~4h, crush, cross 200 meshes, mixing, obtain raw material mixed powder；
(2) raw material mixed powder that step (1) obtains is added in the alcoholic solution that volume fraction is 60%, the raw material
The weight ratio of mixture and alcoholic solution is 1:3, is ultrasonically treated 10min, impregnates 7 days at 30-35 DEG C, obtains the treatment gout
Chinese medicine composition.
Embodiment 2
The external medicine composition for treating gout, the raw material including following parts by weight:
A group: 50 parts of red ant, 50 parts of silky ant, 80 parts of caulis piperis futokadsurae, 80 parts of philippine flemingia root, 80 parts of cortex acanthopanacis, centella 80
Part, 90 parts of Herba Polygoni Runcinati, 90 parts of drilling wind；
B group: 50 parts of safflower, 80 parts of lopseed, 90 parts of the root of Chinese clematis, 90 parts of glaucescent fissistigma root, 80 parts of Radix zanthoxyli, erythrina bark 80
Part, 90 parts of stauntonvine, 90 parts of sweetberry jointfir；
C group: 80 parts of decumbent corydalis tuber, 80 parts of spinyleaf pricklyash root, 90 parts of see swelling, 80 parts of I. henry Diels, 90 parts of Chinese sumac, jobstears root 90
Part, 80 parts of Pterospermi Heterophylli, 90 parts of rhizoma dioscoreae nipponicae；
D group: 80 parts of rhizoma atractylodis, 80 parts of radix achyranthis bidentatae, 80 parts of Cortex Phellodendri, 90 parts of Herba Lycopi, 80 parts of rheum officinale, 90 parts of cape jasmine, 70 parts of Radix Salviae Miltiorrhizae, the Qin
80 parts of Macrophylla, 80 parts of Radix Angelicae Pubescentis, 80 parts of bush, 50 parts of peppermint, 90 parts of ramulus mori.
The preparation method of the external medicine composition of above-mentioned treatment gout, comprising the following steps:
(1) raw material is weighed according to parts by weight, is respectively -0.12~-0.05MPa in vacuum degree, temperature is 55~65
DEG C drying 2~3h, crush, cross 500 meshes, mixing, obtain raw material mixed powder；
(2) raw material mixed powder that step (1) obtains is added in the alcoholic solution that volume fraction is 75%, the raw material
The weight ratio of mixture and alcoholic solution is 1:6, is ultrasonically treated 20min, is impregnated 15 days at 10~15 DEG C, and the treatment pain is obtained
The Chinese medicine composition of wind.
Embodiment 3
The external medicine composition for treating gout, the raw material including following parts by weight:
A group: 35 parts of red ant, 35 parts of silky ant, 65 parts of caulis piperis futokadsurae, 60 parts of philippine flemingia root, 65 parts of cortex acanthopanacis, centella 60
Part, 70 parts of Herba Polygoni Runcinati, 70 parts of drilling wind；
B group: 35 parts of safflower, 60 parts of lopseed, 70 parts of the root of Chinese clematis, 70 parts of glaucescent fissistigma root, 60 parts of Radix zanthoxyli, erythrina bark 60
Part, 70 parts of stauntonvine, 70 parts of sweetberry jointfir；
C group: 65 parts of decumbent corydalis tuber, 65 parts of spinyleaf pricklyash root, 70 parts of see swelling, 60 parts of I. henry Diels, 70 parts of Chinese sumac, jobstears root 70
Part, 60 parts of Pterospermi Heterophylli, 70 parts of rhizoma dioscoreae nipponicae；
D group: 60 parts of rhizoma atractylodis, 65 parts of radix achyranthis bidentatae, 60 parts of Cortex Phellodendri, 70 parts of Herba Lycopi, 65 parts of rheum officinale, 70 parts of cape jasmine, 55 parts of Radix Salviae Miltiorrhizae, the Qin
60 parts of Macrophylla, 60 parts of Radix Angelicae Pubescentis, 60 parts of bush, 35 parts of peppermint, 70 parts of ramulus mori.
The preparation method of the external medicine composition of above-mentioned treatment gout, comprising the following steps:
(1) raw material is weighed according to parts by weight, is respectively -0.12~-0.05MPa in vacuum degree, temperature is 50~55
DEG C drying 2.5~3.5h, crush, cross 400 meshes, mixing, obtain raw material mixed powder；
(2) raw material mixed powder that step (1) obtains is added in the alcoholic solution that volume fraction is 75%, the raw material
The weight ratio of mixture and alcoholic solution is 1:4, is ultrasonically treated 15min, impregnates 7 days at 30-35 DEG C, obtains the treatment gout
Chinese medicine composition.
Embodiment 4
The external medicine composition for treating gout, the raw material including following parts by weight:
A group: 45 parts of red ant, 45 parts of silky ant, 75 parts of caulis piperis futokadsurae, 70 parts of philippine flemingia root, 75 parts of cortex acanthopanacis, centella 70
Part, 80 parts of Herba Polygoni Runcinati, 80 parts of drilling wind；
B group: 45 parts of safflower, 70 parts of lopseed, 80 parts of the root of Chinese clematis, 80 parts of glaucescent fissistigma root, 70 parts of Radix zanthoxyli, erythrina bark 70
Part, 80 parts of stauntonvine, 80 parts of sweetberry jointfir；
C group: 75 parts of decumbent corydalis tuber, 75 parts of spinyleaf pricklyash root, 80 parts of see swelling, 70 parts of I. henry Diels, 80 parts of Chinese sumac, jobstears root 80
Part, 70 parts of Pterospermi Heterophylli, 80 parts of rhizoma dioscoreae nipponicae；
D group: 70 parts of rhizoma atractylodis, 75 parts of radix achyranthis bidentatae, 70 parts of Cortex Phellodendri, 80 parts of Herba Lycopi, 75 parts of rheum officinale, 80 parts of cape jasmine, 65 parts of Radix Salviae Miltiorrhizae, the Qin
70 parts of Macrophylla, 70 parts of Radix Angelicae Pubescentis, 70 parts of bush, 45 parts of peppermint, 80 parts of ramulus mori.
The preparation method of the external medicine composition of above-mentioned treatment gout, comprising the following steps:
(1) raw material is weighed according to parts by weight, is respectively -0.12~-0.05MPa in vacuum degree, temperature is 50~55
DEG C drying 2.5~3.5h, crush, cross 400 meshes, mixing, obtain raw material mixed powder；
(2) raw material mixed powder that step (1) obtains is added in the alcoholic solution that volume fraction is 75%, the raw material
The weight ratio of mixture and alcoholic solution is 1:4, is ultrasonically treated 15min, impregnates 7 days at 30-35 DEG C, obtains the treatment gout
External medicine composition.
Embodiment 5
The external medicine composition for treating gout, the raw material including following parts by weight:
A group: 40 parts of red ant, 40 parts of silky ant, 70 parts of caulis piperis futokadsurae, 65 parts of philippine flemingia root, 70 parts of cortex acanthopanacis, centella 65
Part, 75 parts of Herba Polygoni Runcinati, 75 parts of drilling wind；
B group: 40 parts of safflower, 65 parts of lopseed, 75 parts of the root of Chinese clematis, 75 parts of glaucescent fissistigma root, 65 parts of Radix zanthoxyli, erythrina bark 65
Part, 75 parts of stauntonvine, 75 parts of sweetberry jointfir；
C group: 70 parts of decumbent corydalis tuber, 70 parts of spinyleaf pricklyash root, 75 parts of see swelling, 65 parts of I. henry Diels, 75 parts of Chinese sumac, jobstears root 75
Part, 65 parts of Pterospermi Heterophylli, 75 parts of rhizoma dioscoreae nipponicae；
D group: 65 parts of rhizoma atractylodis, 70 parts of radix achyranthis bidentatae, 65 parts of Cortex Phellodendri, 75 parts of Herba Lycopi, 70 parts of rheum officinale, 75 parts of cape jasmine, 60 parts of Radix Salviae Miltiorrhizae, the Qin
65 parts of Macrophylla, 65 parts of Radix Angelicae Pubescentis, 65 parts of bush, 40 parts of peppermint, 75 parts of ramulus mori.
The preparation method of the external medicine composition of above-mentioned treatment gout, comprising the following steps:
(1) raw material is weighed according to parts by weight, is respectively -0.12~-0.05MPa in vacuum degree, temperature is 50~55
DEG C drying 2.5~3.5h, crush, cross 400 meshes, mixing, obtain raw material mixed powder；
(2) raw material mixed powder that step (1) obtains is added in the alcoholic solution that volume fraction is 75%, the raw material
The weight ratio of mixture and alcoholic solution is 1:4, is ultrasonically treated 15min, impregnates 7 days at 30-35 DEG C, obtains the treatment gout
External medicine composition.
Test example
1. skin anaphylactic test
Tested wistar male rat 30,280 ± 10g of average weight are taken, it, will by the dorsal area unhairing of every rat
Rat is equally divided into two groups, and one group is test group, and another group is control group.The treatment gout that test group spraying embodiment 5 obtains
Chinese medicine composition 0.2g/ only, control group sprays distilled water 0.2g/ only, and spraying daily three times, was observed by 7 days.As a result are as follows:
Test group and control rats back unhairing part are without allergic phenomenas such as erythema, oedema.As a result illustrate in provided by the invention
Drug composition is nonirritant.
2. acute toxicity test
Tested wistar male rat 30,280 ± 10g of average weight are taken, it, will by the dorsal area unhairing of every rat
Rat is equally divided into three groups, respectively test group 1, test group 2 and control group, and test group 1 is during spraying embodiment 4 obtains daily
Drug composition, test group 2 spray the Chinese medicine composition that embodiment 5 obtains, and control group sprays distilled water, every time every group of quantity for spray
It is 0.2g/, spraying daily three times, observes weight, excrement, the colour of skin of rat after 2 weeks.As a result are as follows: test group 1, test group 2
With every group of the rat of test group 3 in every weight averagely increase by 0.2~0.4g, excrement and the colour of skin are normal, non-toxic anti-
It answers.It is safe that this illustrates that the external medicine composition for the treatment of gout provided by the invention uses.
3. therapeutic effect
Count the therapeutic effect of patient with gout so far in 2013.Wherein Appreciation gist are as follows:
Thoroughly alleviate: after external medicine composition 1-20 days of spraying treatment gout provided by the invention, redness and swelling of joints
Phenomenon disappears, can be free movable without obvious pain, and site of pathological change joint function recovery is normal；
It is effective: after external medicine composition 1-20 days of spraying treatment gout provided by the invention, redness and swelling of joints phenomenon
Substantially reduced, pain is substantially reduced, and joint motion is relatively free；
Invalid: redness and swelling of joints phenomenon is still or exacerbation, pain aggravate or without mitigation, and joint motion is limited.
Received 689 acute gout patients so far in 2013 are counted, by rubbing treatment acute pain provided by the invention
The external medicine composition of wind, 198 people are thoroughly alleviated, and 435 people are using effectively, and 56 people are invalid, and total effective rate reaches 91.87%.
This illustrates that pain caused by gout can be effectively relieved in the external medicine composition for the treatment of gout provided by the invention, to gout
Therapeutic effect is obvious.
4. typical case
Case 1: Lee, male, 39 years old, section cadre.Because of work relationship, more, right crus of diaphragm big toe redness before 3 years is usually treated with courtesy
Pain carries out sliding formwork biopsy discovery urate crystal to hospital, claps the inspection of X piece and find right crus of diaphragm big toe Bones and joints no abnormality seen.Through
Symptom improves after treatment.Because work is tired, eating and drinking without temperance, induced pain wind frequently breaks out, difficulty in walking within nearest 2 years.Then it seeks medical advice in hair
Bright people.Symptoms include: right crus of diaphragm big toe is red and swollen obvious, and it is fierce to touch affected part pain with cotton swab.The embodiment of the present invention 5 is gently applied outside at once to mention
The Chinese medicine composition of confession several times, about 20 minutes or so, alleviated rapidly, and tiptoe can land on foot by pain, adheres to using 5 days, office
Portion's pain symptom disappears, can normal walking.
Case 2: Zhang, male, 48 years old, individual enterprise boss, nearly 200 jin of weight, five years ago obtained gout, a Nian Dangzhong, often
Midnight breaking-out, it is agonizing.Once midnight breaking-out is sought medical advice the Chinese traditional medicine composition in inventor, provided using the embodiment of the present invention 3
Object, less than half an hour, pain relief, and latter feel was slept to daybreak.Zhang breaks out every time uses the embodiment of the present invention 3 to provide
The external medicine composition for treating gout is rubbed, and erasing can fast pain relief every time.
Case 3: Liao, female, 55 years old, cleaner lived frugally because of family's difficulty, often buys a little bean curd when dish is eaten.And because
Work relationship, wind and rain come in rain to go, overwork, and for a long time, gout rises suddenly.Patient has an attack of one's old illness in Summer Morning, in great pain,
Constantly, seek medical advice in inventor, physical examination discovery: right crus of diaphragm Huai inflammation heat is red and swollen, pain for groan, and 38.8 DEG C of body temperature.Horse back symptomatic treatment is stood
The Traditional Chinese medicinal liquor that the treatment gout that embodiment 4 obtains is dipped with gauze applies in affected part and gives cooling processing simultaneously.About half is small
When or so no longer moan, pain is eased, and hereafter suffers from the Traditional Chinese medicinal liquor erasing that morbidity is obtained using the embodiment of the present invention 4
Place, pain is effectively relieved within half an hour every time.
The above description is merely a specific embodiment, but scope of protection of the present invention is not limited thereto, also fits
It is used for the symptoms crowd such as rheumatism bone disease.Anyone skilled in the art the invention discloses technical scope
It is interior, it can easily think of the change or the replacement, should be covered by the protection scope of the present invention.Therefore, protection scope of the present invention
It should be based on the protection scope of the described claims.
Claims (10)
1. a kind of external medicine composition for treating gout, which is characterized in that the raw material including following parts by weight:
A group: 30~50 parts of red ant, 30~50 parts of silky ant, 60~80 parts of caulis piperis futokadsurae, 50~80 parts of philippine flemingia root, cortex acanthopanacis 60
~80 parts, 50~80 parts of centella, 60~90 parts of Herba Polygoni Runcinati, 60~90 parts of drilling wind；
B group: 30~50 parts of safflower, 50~80 parts of lopseed, 60~90 parts of the root of Chinese clematis, 60~90 parts of glaucescent fissistigma root, Radix zanthoxyli 50
~80 parts, 50~80 parts of erythrina bark, 60~90 parts of stauntonvine, 60~90 parts of sweetberry jointfir；
C group: 60~80 parts of decumbent corydalis tuber, 60~80 parts of spinyleaf pricklyash root, 60~90 parts of see swelling, 50~80 parts of I. henry Diels, Chinese sumac 60
~90 parts, 60~90 parts of jobstears root, 50~80 parts of Pterospermi Heterophylli, 60~90 parts of rhizoma dioscoreae nipponicae；
D group: 50~80 parts of rhizoma atractylodis, 60~80 parts of radix achyranthis bidentatae, 50~80 parts of Cortex Phellodendri, 60~90 parts of Herba Lycopi, 60~80 parts of rheum officinale, cape jasmine
60~90 parts, 50~70 parts of Radix Salviae Miltiorrhizae, 50~80 parts of gentianae macrophyllae, 50~80 parts of Radix Angelicae Pubescentis, 50~80 parts of bush, 30~50 parts of peppermint, mulberry
60~90 parts of branch.
2. the external medicine composition for the treatment of gout according to claim 1, which is characterized in that including following parts by weight
Raw material:
A group: 35~45 parts of red ant, 35~45 parts of silky ant, 65~75 parts of caulis piperis futokadsurae, 60~70 parts of philippine flemingia root, cortex acanthopanacis 65
~75 parts, 60~70 parts of centella, 70~80 parts of Herba Polygoni Runcinati, 70~80 parts of drilling wind；
B group: 35~45 parts of safflower, 60~70 parts of lopseed, 70~80 parts of the root of Chinese clematis, 70~80 parts of glaucescent fissistigma root, Radix zanthoxyli 60
~70 parts, 60~70 parts of erythrina bark, 70~80 parts of stauntonvine, 70~80 parts of sweetberry jointfir；
C group: 65~75 parts of decumbent corydalis tuber, 65~75 parts of spinyleaf pricklyash root, 70~80 parts of see swelling, 60~70 parts of I. henry Diels, Chinese sumac 70
~80 parts, 70~80 parts of jobstears root, 60~70 parts of Pterospermi Heterophylli, 70~80 parts of rhizoma dioscoreae nipponicae；
D group: 60~70 parts of rhizoma atractylodis, 65~75 parts of radix achyranthis bidentatae, 60~70 parts of Cortex Phellodendri, 70~80 parts of Herba Lycopi, 65~75 parts of rheum officinale, cape jasmine
70~80 parts, 55~65 parts of Radix Salviae Miltiorrhizae, 60~70 parts of gentianae macrophyllae, 60~70 parts of Radix Angelicae Pubescentis, 60~70 parts of bush, 35~45 parts of peppermint, mulberry
70~80 parts of branch.
3. the external medicine composition for the treatment of gout according to claim 1, which is characterized in that including following parts by weight
Raw material:
A group: 40 parts of red ant, 40 parts of silky ant, 70 parts of caulis piperis futokadsurae, 65 parts of philippine flemingia root, 70 parts of cortex acanthopanacis, 65 parts of centella, nine
75 parts of imperial disk, 75 parts of drilling wind；
B group: 40 parts of safflower, 65 parts of lopseed, 75 parts of the root of Chinese clematis, 75 parts of glaucescent fissistigma root, 65 parts of Radix zanthoxyli, 65 parts of erythrina bark, open country
75 parts of pawpaw, 75 parts of sweetberry jointfir；
C group: 70 parts of decumbent corydalis tuber, 70 parts of spinyleaf pricklyash root, 75 parts of see swelling, 65 parts of I. henry Diels, 75 parts of Chinese sumac, 75 parts of jobstears root, half
65 parts of maple lotus, 75 parts of rhizoma dioscoreae nipponicae；
D group: 65 parts of rhizoma atractylodis, 70 parts of radix achyranthis bidentatae, 65 parts of Cortex Phellodendri, 75 parts of Herba Lycopi, 70 parts of rheum officinale, 75 parts of cape jasmine, 60 parts of Radix Salviae Miltiorrhizae, gentianae macrophyllae 65
Part, 65 parts of Radix Angelicae Pubescentis, 65 parts of bush, 40 parts of peppermint, 75 parts of ramulus mori.
4. the preparation method of the external medicine composition of any treatment gout of claims 1 to 3, which is characterized in that packet
Include following steps:
(1) raw material is weighed according to parts by weight, be respectively dried, crushed, is sieved, mixing obtains raw material mixed powder；
(2) raw material mixed powder that step (1) obtains is added in alcoholic solution, impregnates 7~15 days, obtains the treatment gout
External medicine composition.
5. the preparation method of the external medicine composition for the treatment of gout according to claim 4, which is characterized in that step
(1) in, the temperature of the drying is 50~65 DEG C, and drying time is 2~4h.
6. the preparation method of the external medicine composition for the treatment of gout according to claim 5, which is characterized in that step
(1) in, the drying is vacuum drying, and vacuum degree is -0.12~-0.05MPa.
7. the preparation method of the external medicine composition for the treatment of gout according to claim 4, which is characterized in that step
(1) in, the partial size of the raw material mixed powder is 200~500 mesh.
8. the preparation method of the external medicine composition for the treatment of gout according to claim 4, which is characterized in that step
(2) in, the volume fraction of the alcoholic solution is 60~75%.
9. the preparation method of the external medicine composition for the treatment of gout according to claim 8, which is characterized in that step
(2) in, the weight ratio of the raw mixture and alcoholic solution is 1:3~6.
10. the preparation method of the external medicine composition for the treatment of gout according to claim 4, which is characterized in that step
(2) in, the raw material mixed powder that step (1) obtains is added in alcoholic solution, be ultrasonically treated 10~20min, then impregnate 7~
15 days.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111939196A (en) * | 2020-08-06 | 2020-11-17 | 李文秀 | Essential oil pain relieving ointment for relieving gout |
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2019
- 2019-03-22 CN CN201910225132.7A patent/CN109758553A/en active Pending
Non-Patent Citations (1)
| Title |
|---|
| 邱晓堂: "张永杰治疗痛风性关节炎经验", 《中国中医基础医学杂志》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111939196A (en) * | 2020-08-06 | 2020-11-17 | 李文秀 | Essential oil pain relieving ointment for relieving gout |
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Effective date of registration: 20210527 Address after: 100000 Building 2, 12 xidawang Road, Chaoyang District, Beijing Applicant after: Beijing longxiushan Institute of traditional Chinese Medicine Address before: 341000 No.1-1, upper group, Ma Lu, Chenglong village, Chenglong Town, Longnan County, Ganzhou City, Jiangxi Province Applicant before: Cai Jianhua |
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Application publication date: 20190517 |