CN109692277A - A kind of Chinese herbal and crude drugs preparations for treating diabetes - Google Patents
A kind of Chinese herbal and crude drugs preparations for treating diabetes Download PDFInfo
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- CN109692277A CN109692277A CN201910074545.XA CN201910074545A CN109692277A CN 109692277 A CN109692277 A CN 109692277A CN 201910074545 A CN201910074545 A CN 201910074545A CN 109692277 A CN109692277 A CN 109692277A
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- chinese herbal
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- diabetes
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Abstract
The invention discloses a kind of Chinese herbal and crude drugs preparations for treating diabetes, the bulk pharmaceutical chemicals composition and weight of the Chinese herbal and crude drugs preparations are made are as follows: Radix Astragali 20-30g, Rhizoma Atractylodis Macrocephalae 15-25g, Radix Paeoniae Alba 15-20g, rhizoma alismatis 15-20g, Pachyrhizua angulatus 25-35g, radices trichosanthis 25-35g, dendrobium nobile 20-30g, radix scutellariae 15-25g, Radix Notoginseng 15-20g, ganoderma lucidum 20-30g, radix paeoniae rubra 15-20g, Radix Rehmanniae 15-20g, Habenaria Ciliolaris Kranzl 30-40g.The present invention is the understanding based on Chinese medicine for onset diabetes mechanism, and the research to each taste herbal pharmacology function, in conjunction with many years clinical experience and adjust repeatedly and select out；Selected 13 taste Chinese herbal medicine is raw material, is acted synergistically between each raw material, has complementary advantages, brings out the best in each other, and fundamentally improves and eradicate diabetes, has excellent therapeutic effect to diabetes, nontoxic to human body Small side effects；And raw material is easy to get, and prepares simply, and it is cheap, it is convenient to take.
Description
Technical field
The present invention relates to pharmaceutical technology fields, and in particular to a kind of Chinese herbal and crude drugs preparations for treating diabetes.
Background technique
Diabetes are one group of clinical syndromes as caused by h and E factor interaction.It is primarily due to pancreas islet
Element secretes the metabolic disease caused by absolute or relative deficiency characterized by hyperglycemia.Persistent high blood sugar and long-term metabolic disorder
Etc. the damage and its dysfunction and failure that can lead to body tissue's organ, especially eye, kidney, angiocarpy and nervous system.Sternly
Severe one can cause dehydration, the acute complications such as electrolyte disturbance and acid-base imbalance ketoacidosis and Hyperosmotic coma.Glycosuria
The symptom of disease can be divided into two major classes: a major class is performance related with metabolic disorder, especially related with hyperglycemia " more than three one
Less " -- diuresis, more drinks, more foods and syntexis are more common in type 1 diabetes, and diabetes B is not fairly obvious or only part shows,
Another major class is various acute, chronic complicating diseases performances.With the improvement of living standards, the disease incidence of diabetes gradually mentions
Height, the treatment of diabetes at present mainly include diabetes education, dietary therapy, exercise therapy, drug therapy, blood sugar monitoring, with
And other cardiovascular disease risk factors detect and control several aspects.Wherein, in drug therapy, drug in the prior art
There are various shortcomings, for example, it is expensive, side effect is obvious, should not take for a long time, be unable to satisfy diabetes
The demand of patient.
Summary of the invention
The purpose of the present invention is to provide a kind of Chinese herbal and crude drugs preparations for treating diabetes, Chinese herbal and crude drugs preparations obtained have drop
The effect of blood glucose, has excellent therapeutic effect, nontoxic to human body Small side effects, cheap, the side of taking to diabetes
Just.
To achieve the goals above, the present invention is achieved through the following technical solutions: a kind of Chinese herbal medicine for treating diabetes
Preparation, the bulk pharmaceutical chemicals of the Chinese herbal and crude drugs preparations by Radix Astragali, Rhizoma Atractylodis Macrocephalae, Radix Paeoniae Alba, rhizoma alismatis, Pachyrhizua angulatus, radices trichosanthis, dendrobium nobile, radix scutellariae, Radix Notoginseng,
Ganoderma lucidum, radix paeoniae rubra, Radix Rehmanniae, Habenaria Ciliolaris Kranzl composition.
Specifically, be made the Chinese herbal and crude drugs preparations bulk pharmaceutical chemicals composition and weight are as follows: Radix Astragali 20-30g, Rhizoma Atractylodis Macrocephalae 15-25g,
Radix Paeoniae Alba 15-20g, rhizoma alismatis 15-20g, Pachyrhizua angulatus 25-35g, radices trichosanthis 25-35g, dendrobium nobile 20-30g, radix scutellariae 15-25g, Radix Notoginseng 15-
20g, ganoderma lucidum 20-30g, radix paeoniae rubra 15-20g, Radix Rehmanniae 15-20g, Habenaria Ciliolaris Kranzl 30-40g.
In a preferred embodiment of this invention, the bulk pharmaceutical chemicals composition and weight of the Chinese herbal and crude drugs preparations is made are as follows: Radix Astragali 22-
28g, Rhizoma Atractylodis Macrocephalae 18-23g, Radix Paeoniae Alba 16-19g, rhizoma alismatis 16-19g, Pachyrhizua angulatus 28-32g, radices trichosanthis 28-32g, dendrobium nobile 22-28g, radix scutellariae
18-23g, Radix Notoginseng 16-19g, ganoderma lucidum 22-28g, radix paeoniae rubra 16-19g, Radix Rehmanniae 16-19g, Habenaria Ciliolaris Kranzl 32-38g.
In present invention further optimization embodiment, the bulk pharmaceutical chemicals composition and weight of the Chinese herbal and crude drugs preparations is made
Are as follows: Radix Astragali 25g, Rhizoma Atractylodis Macrocephalae 20g, Radix Paeoniae Alba 17.5g, rhizoma alismatis 17.5g, Pachyrhizua angulatus 30g, radices trichosanthis 30g, dendrobium nobile 25g, radix scutellariae 20g, Radix Notoginseng
17.5g, ganoderma lucidum 25g, radix paeoniae rubra 17.5g, Radix Rehmanniae 17.5g, Habenaria Ciliolaris Kranzl 35g.
Heretofore described Chinese herbal and crude drugs preparations mean decoction for oral administration, powder, capsule or pill.
Wherein, the decoction is prepared as follows: weighing each bulk pharmaceutical chemicals by weight, each bulk pharmaceutical chemicals are added after mixing
Water heating, high fire are boiled to boiling, are then boiled 30 minutes with small fire, the strainer filtering by the medical fluid after tanning through 100 mesh, weight
Multiple above-mentioned steps decoct 3 times, merging filtrate to get.
Preferably, the ratio of the weight of the total weight and water of each bulk pharmaceutical chemicals is 1:(5-10).
Wherein, the pill is prepared as follows: being weighed each bulk pharmaceutical chemicals by weight and is crushed after mixing, be sieved to obtain grain
Diameter be less than 0.03mm medicinal powder, pill is then made, by pill dry to get.
Herein, the above medicinal material can be bought both from known plant in China's medicinal material market.Such as: it is yellow
Stilbene also known as cotton stilbene, astragalus, only mulberry, another name for Sichuan Province rouge, hundred, hundred absorbent cotton, kurarinone；Rhizoma Atractylodis Macrocephalae nickname small wooden raft Ji, Yu Shu, winter Rhizoma Atractylodis Macrocephalae, wash rice art, poplar
Small wooden raft, Wu Shu, mountain Ji；Radix Paeoniae Alba nickname auricledleaf swallowwort root；Pachyrhizua angulatus is also known as without ground-slag Pueraria lobota；Radices trichosanthis nickname radices trichosanthis, radices trichosanthis, pollen, building
Root；Dendrobium nobile also known as bracketplant, Jin Chai；The light Siberian cocklebur of radix scutellariae alias, Siberian cocklebur, sub- Siberian cocklebur, withered Siberian cocklebur, stalwart Siberian cocklebur, camellia root；Radix Notoginseng nickname pseudo-ginseng,
Panax pseudoginseng, radix notoginseng, literary state Radix Notoginseng；Ganoderma lucidum nickname red sesame, red sesame, red sesame, seocho, Ganoderma Lucidum, Ganoderma, 10000 years gill fungus；It is red
The also known as wooden Chinese herbaceous peony of Chinese herbaceous peony, careless Chinese herbaceous peony, red Chinese herbaceous peony, comospore radix paeoniae rubra；Radix Rehmanniae alias radix rehmanniae recen, wild country Huang, mountain cigarette root.
Now the primary efficacy of above-mentioned each taste bulk pharmaceutical chemicals is summarized as follows:
Radix Astragali: there is enhancing body's immunity, liver protection, diuresis, anti-aging, resisting stress, decompression and wide antibacterial
Effect.
Rhizoma Atractylodis Macrocephalae: medicinal function transports spleen medicine, and Wen Xinlie bitter in taste has the benefits of turbid eliminating dampness, change, analgesic.
Radix Paeoniae Alba: calming the liver and relieving pain, nourishing blood for regulating menstruation, astringing YIN to stop sweating；For headache and dizziness, hypochondriac pain, abdominal pain, four limbs contraction pain, the deficiency of blood
It is sallow, irregular menstruation, spontaneous perspiration, night sweat.
Rhizoma alismatis: Li Shui, excreting dampness expel the heat-evil；Cure mainly the diseases such as nephritic dropsy, pyelonephritis, enteritis diarrhea, difficult urination.
Pachyrhizua angulatus: there is expelling pathogenic factors from muscles and skin to promote the production of body fluid, promoting eruption, bring down a fever, Shengyang Zhixie and other effects；Cure mainly fever caused by exogenous pathogens headache, stiff nape and back,
The diseases such as measles without adequate eruption, thirsty, diarrhea, hypertension.
Radices trichosanthis: clearing heat-fire promotes the production of body fluid to quench thirst, apocenosis detumescence；Cure mainly that pyreticosis is thirsty, quenches one's thirst, jaundice, dryness of the lung hemoptysis, carbuncle
Swollen, hemorrhoid impotence.
Dendrobium nobile: reinforcing stomach reg fluid, nourishing Yin and clearing heat, improving eyesight, anti-aging have drive solution abnormal heat, the curative effects such as strong yin of strengthening the essence to human body.
Radix scutellariae: have and eliminate nervous and uneasiness, make effect that physical condition is stable.
Radix Notoginseng: dissipating stasis and stanching bleeding, detumescence ding-tong；For spitting blood, haematemesis, bleeding from five sense organs or subcutaneous tissue, hematochezia, metrorrhagia and metrostaxis, traumatic hemorrhage, chest and abdomen thorn
Bitterly, tumbling and swelling.
Ganoderma lucidum: having invigorating qi for tranquilization, relieving cough and asthma effect, is used for dizziness egersis, shortness of breath and palpitation, consumptive disease cough and asthma.
Radix paeoniae rubra: there is the effect of clearing heat and cooling blood, promoting blood circulation.
Radix Rehmanniae: there is the effect of clearing heat and cooling blood, benefiting yin are promoted the production of body fluid；Enter ying blood, high fever coma, dry tongue for warm heat disease heat
It is deep red.
Habenaria Ciliolaris Kranzl: have effects that enriching yin and nourishing kidney；It controls the deficiency of liver-yin and kidney-yin, have a dizzy spell.
The above all medicines share reaches hypoglycemic effect, has excellent therapeutic effect, and safe and non-toxic pair to diabetes
Effect.
It compared with prior art, is based on Chinese medicine for onset diabetes the invention has the following beneficial effects: the present invention
The understanding of mechanism, and the research to each taste herbal pharmacology function, in conjunction with many years clinical experience and adjust and select out repeatedly
Come；Selected 13 taste Chinese herbal medicine is raw material, is acted synergistically between each raw material, has complementary advantages, brings out the best in each other, fundamentally improve
With radical cure diabetes, there is excellent therapeutic effect to diabetes, it is nontoxic to human body Small side effects；And raw material is easy to get, and matches
System is simple, cheap, convenient to take.
Specific embodiment
The following detailed description of a specific embodiment of the invention, as part of this specification, by embodiment come
Illustrate that the principle of the present invention, other aspects of the present invention, feature and its advantage will become apparent by the detailed description.
Embodiment 1.Treat the Chinese herbal and crude drugs preparations of diabetes, bulk pharmaceutical chemicals composition and weight are as follows: Radix Astragali 25g, Rhizoma Atractylodis Macrocephalae 20g,
Radix Paeoniae Alba 17.5g, rhizoma alismatis 17.5g, Pachyrhizua angulatus 30g, radices trichosanthis 30g, dendrobium nobile 25g, radix scutellariae 20g, Radix Notoginseng 17.5g, ganoderma lucidum 25g, radix paeoniae rubra
17.5g, Radix Rehmanniae 17.5g, Habenaria Ciliolaris Kranzl 35g.Water is added to heat after mixing each bulk pharmaceutical chemicals, the total weights of each bulk pharmaceutical chemicals and water
The ratio of weight is 1:8, and high fire is boiled to boiling, is then boiled 30 minutes with small fire, the filter by the medical fluid after tanning through 100 mesh
Net filtration, repeat the above steps decoction 3 times, merging filtrate to get.Usage: 3 times a day, each two liquid medicine of 1-2, boiled water is taken after mixing it with water.
Embodiment 2.Treat the Chinese herbal and crude drugs preparations of diabetes, bulk pharmaceutical chemicals composition and weight are as follows: Radix Astragali 22g, Rhizoma Atractylodis Macrocephalae 18g,
Radix Paeoniae Alba 16g, rhizoma alismatis 16g, Pachyrhizua angulatus 28g, radices trichosanthis 28g, dendrobium nobile 22g, radix scutellariae 18g, Radix Notoginseng 16g, ganoderma lucidum 22g, radix paeoniae rubra 16g, life
Ground 16g, Habenaria Ciliolaris Kranzl 32g.The preparation method is the same as that of Example 1.Usage: 3 times a day, each two liquid medicine of 1-2, boiled water is taken after mixing it with water.
Embodiment 3.Treat the Chinese herbal and crude drugs preparations of diabetes, bulk pharmaceutical chemicals composition and weight are as follows: Radix Astragali 28g, Rhizoma Atractylodis Macrocephalae 23g,
Radix Paeoniae Alba 19g, rhizoma alismatis 19g, Pachyrhizua angulatus 32g, radices trichosanthis 32g, dendrobium nobile 28g, radix scutellariae 23g, Radix Notoginseng 19g, ganoderma lucidum 28g, radix paeoniae rubra 19g, life
Ground 19g, Habenaria Ciliolaris Kranzl 38g.The preparation method is the same as that of Example 1.Usage: 3 times a day, each two liquid medicine of 1-2, boiled water is taken after mixing it with water.
Embodiment 4.Treat the Chinese herbal and crude drugs preparations of diabetes, bulk pharmaceutical chemicals composition and weight are as follows: Radix Astragali 20g, Rhizoma Atractylodis Macrocephalae 15g,
Radix Paeoniae Alba 15g, rhizoma alismatis 15g, Pachyrhizua angulatus 25g, radices trichosanthis 25g, dendrobium nobile 20g, radix scutellariae 15g, Radix Notoginseng 15g, ganoderma lucidum 20g, radix paeoniae rubra 15g, life
Ground 15g, Habenaria Ciliolaris Kranzl 30g.The preparation method is the same as that of Example 1.Usage: 3 times a day, each two liquid medicine of 1-2, boiled water is taken after mixing it with water.
Embodiment 5.Treat the Chinese herbal and crude drugs preparations of diabetes, bulk pharmaceutical chemicals composition and weight are as follows: Radix Astragali 30g, Rhizoma Atractylodis Macrocephalae 25g,
Radix Paeoniae Alba 20g, rhizoma alismatis 20g, Pachyrhizua angulatus 35g, radices trichosanthis 35g, dendrobium nobile 30g, radix scutellariae 25g, Radix Notoginseng 20g, ganoderma lucidum 30g, radix paeoniae rubra 20g, life
Ground 20g, Habenaria Ciliolaris Kranzl 40g.The preparation method is the same as that of Example 1.Usage: 3 times a day, each two liquid medicine of 1-2, boiled water is taken after mixing it with water.
Embodiment 6.Treat the Chinese herbal and crude drugs preparations of diabetes, bulk pharmaceutical chemicals composition and weight are as follows: Radix Astragali 25g, Rhizoma Atractylodis Macrocephalae 20g,
Radix Paeoniae Alba 17.5g, rhizoma alismatis 17.5g, Pachyrhizua angulatus 30g, radices trichosanthis 30g, dendrobium nobile 25g, radix scutellariae 20g, Radix Notoginseng 17.5g, ganoderma lucidum 25g, radix paeoniae rubra
17.5g, Radix Rehmanniae 17.5g, Habenaria Ciliolaris Kranzl 35g.Each bulk pharmaceutical chemicals are weighed by weight to crush after mixing, be sieved partial size is less than
The medicinal powder of 0.03mm, is then made pill, by pill dry to get.Usage: 3 times a day, each 3-5g, boiled water is taken after mixing it with water.
Embodiment 7.Treat the Chinese herbal and crude drugs preparations of diabetes, bulk pharmaceutical chemicals composition and weight are as follows: Radix Astragali 22g, Rhizoma Atractylodis Macrocephalae 18g,
Radix Paeoniae Alba 16g, rhizoma alismatis 16g, Pachyrhizua angulatus 28g, radices trichosanthis 28g, dendrobium nobile 22g, radix scutellariae 18g, Radix Notoginseng 16g, ganoderma lucidum 22g, radix paeoniae rubra 16g, life
Ground 16g, Habenaria Ciliolaris Kranzl 32g.Preparation method is the same as embodiment 6.Usage: 3 times a day, each 3-5g, boiled water is taken after mixing it with water.
Embodiment 8.Treat the Chinese herbal and crude drugs preparations of diabetes, bulk pharmaceutical chemicals composition and weight are as follows: Radix Astragali 28g, Rhizoma Atractylodis Macrocephalae 23g,
Radix Paeoniae Alba 19g, rhizoma alismatis 19g, Pachyrhizua angulatus 32g, radices trichosanthis 32g, dendrobium nobile 28g, radix scutellariae 23g, Radix Notoginseng 19g, ganoderma lucidum 28g, radix paeoniae rubra 19g, life
Ground 19g, Habenaria Ciliolaris Kranzl 38g.Preparation method is the same as embodiment 6.Usage: 3 times a day, each 3-5g, boiled water is taken after mixing it with water.
Embodiment 9.Treat the Chinese herbal and crude drugs preparations of diabetes, bulk pharmaceutical chemicals composition and weight are as follows: Radix Astragali 20g, Rhizoma Atractylodis Macrocephalae 15g,
Radix Paeoniae Alba 15g, rhizoma alismatis 15g, Pachyrhizua angulatus 25g, radices trichosanthis 25g, dendrobium nobile 20g, radix scutellariae 15g, Radix Notoginseng 15g, ganoderma lucidum 20g, radix paeoniae rubra 15g, life
Ground 15g, Habenaria Ciliolaris Kranzl 30g.Preparation method is the same as embodiment 6.Usage: 3 times a day, each 3-5g, boiled water is taken after mixing it with water.
Embodiment 10.Treat the Chinese herbal and crude drugs preparations of diabetes, bulk pharmaceutical chemicals composition and weight are as follows: Radix Astragali 30g, Rhizoma Atractylodis Macrocephalae 25g,
Radix Paeoniae Alba 20g, rhizoma alismatis 20g, Pachyrhizua angulatus 35g, radices trichosanthis 35g, dendrobium nobile 30g, radix scutellariae 25g, Radix Notoginseng 20g, ganoderma lucidum 30g, radix paeoniae rubra 20g, life
Ground 20g, Habenaria Ciliolaris Kranzl 40g.Preparation method is the same as embodiment 6.Usage: 3 times a day, each 3-5g, boiled water is taken after mixing it with water.
Experimental example: the decoction that the embodiment of the present invention 1 is prepared to embodiment 5 is commented by function assessment test come system
Its effect of valence, and using blank control group as control.
1, zoopery
Test method: 18-22g mouse 70 for choosing 4 week old normally feed 1 week adaptation environment in animal feeding room
Afterwards, mouse weight, blood glucose value are surveyed.Wherein 10 mouse it normally will feed as blank control group, and give normal diet always,
Streptozotocin (STZ) is injected intraperitoneally according to the dosage of 70mg/kg in remaining 60 mouse, measures blood glucose value after 72 hours,
Mouse with blood glucose value for 10-25mmol/L is into mould animal, gives high sugar feed always at mould animal.Choose 60 therein
At mould mouse, 6 groups are classified as according to blood glucose value, and keeps every group of average blood sugar value close, every group 10, in addition being used as blank pair
According to the mouse of group, 7 groups in total, 7 groups are respectively as follows: blank control group, model group: giving diabetic mice stomach-filling physiological saline 0.3ml/
d；Decoction 30mg/kg/d is prepared to the diabetic mice stomach-filling embodiment of the present invention 1 to embodiment 5.Daily gastric infusion 1
It is secondary, continuous 30 days, blood glucose value was surveyed after fasting 10h.Test result is as shown in table 1 below.
Influence of the table 1 to diabetes mice model
2, for the curative effect of hyperglycemic patients
Test method: call-up age 30-70 years old diabetic 600 (male to female ratio 1:1)；Wherein, 30-49 years old
Patient and 50-70 years old patient each 300.The clinical symptoms of patient show themselves in that fasting blood sugar is higher than 7.0mmol/L, after the meal
Blood glucose value is in the range of 9-12mmol/L within two hours.Specifically, two class volunteers are divided into 6 groups, i.e., every group includes 30-
49 years old patients 50 and 50-70 years old patient 50；1st group to the 5th group of patient is eaten to embodiment 1 respectively into embodiment 5
The Chinese herbal and crude drugs preparations being prepared, 1.5 liang of liquid medicine, 3 times edible daily every time；With (about 50 DEG C -65 of 50mL warm water when edible
DEG C) take after mixing it with water；Control group, normal diet are set by the 6th group of patient, and does not take any drug.It is continuous 20 days edible, respectively
At the 10th day and the 20th day, the fasting blood sugar and 2h-plasma glucose value of patient are measured.By every group, results are averaged, meter
Obtained specific data are as shown in table 2 below.
Influence of the table 2 to blood sugar in diabetic patients value
3, toxicity test
Selecting weight is the small white mouse 50 (each 25 of male and female) of 18-22g, is divided into 5 groups, every group of male and female each 5, distinguishes stomach-filling
The Chinese herbal and crude drugs preparations that the embodiment of the present invention 1 is prepared to embodiment 5, dosage are 0.5mg/kg, and successive administration 30 days.
When during administration and 1 week after being discontinued, white mouse growth conditions and activity and diet are observed, identifies hematology, blood biochemical analysis, internal organs group
Knit structure and routine urinalysis etc..As a result, it has been found that the health existence of all small white mouses, without any side effects；Anatomic observation blood picture,
Liver function, each organs and tissues state, the indifference compared with normal small white mouse.It is demonstrated experimentally that Chinese herbal and crude drugs preparations provided by the invention
It has no toxic side effect, can use safely.
It should be noted that the case where enumerating in addition to above-described embodiment 1 to embodiment 5, selects other raw material components to match
Than and preparation method thereof parameter (such as embodiment 6 to embodiment 10) be also it is feasible.
The above is a preferred embodiment of the present invention, cannot limit the right model of the present invention with this certainly
It encloses, it is noted that for those skilled in the art, without departing from the principle of the present invention, may be used also
To make several improvement and variation, these, which improve and change, is also considered as protection scope of the present invention.
Claims (8)
1. a kind of Chinese herbal and crude drugs preparations for treating diabetes, which is characterized in that the bulk pharmaceutical chemicals of the Chinese herbal and crude drugs preparations are by Radix Astragali, white
Art, Radix Paeoniae Alba, rhizoma alismatis, Pachyrhizua angulatus, radices trichosanthis, dendrobium nobile, radix scutellariae, Radix Notoginseng, ganoderma lucidum, radix paeoniae rubra, Radix Rehmanniae, Habenaria Ciliolaris Kranzl composition.
2. the Chinese herbal and crude drugs preparations for the treatment of diabetes as described in claim 1, which is characterized in that the Chinese herbal and crude drugs preparations are made
Bulk pharmaceutical chemicals composition and weight are as follows: Radix Astragali 20-30g, Rhizoma Atractylodis Macrocephalae 15-25g, Radix Paeoniae Alba 15-20g, rhizoma alismatis 15-20g, Pachyrhizua angulatus 25-35g, day
Pollen 25-35g, dendrobium nobile 20-30g, radix scutellariae 15-25g, Radix Notoginseng 15-20g, ganoderma lucidum 20-30g, radix paeoniae rubra 15-20g, Radix Rehmanniae 15-20g,
Habenaria Ciliolaris Kranzl 30-40g.
3. the Chinese herbal and crude drugs preparations for the treatment of diabetes as claimed in claim 2, which is characterized in that the Chinese herbal and crude drugs preparations are made
Bulk pharmaceutical chemicals composition and weight are as follows: Radix Astragali 22-28g, Rhizoma Atractylodis Macrocephalae 18-23g, Radix Paeoniae Alba 16-19g, rhizoma alismatis 16-19g, Pachyrhizua angulatus 28-32g, day
Pollen 28-32g, dendrobium nobile 22-28g, radix scutellariae 18-23g, Radix Notoginseng 16-19g, ganoderma lucidum 22-28g, radix paeoniae rubra 16-19g, Radix Rehmanniae 16-19g,
Habenaria Ciliolaris Kranzl 32-38g.
4. the Chinese herbal and crude drugs preparations for the treatment of diabetes as claimed in claim 3, which is characterized in that the Chinese herbal and crude drugs preparations are made
Bulk pharmaceutical chemicals composition and weight are as follows: Radix Astragali 25g, Rhizoma Atractylodis Macrocephalae 20g, Radix Paeoniae Alba 17.5g, rhizoma alismatis 17.5g, Pachyrhizua angulatus 30g, radices trichosanthis 30g, dendrobium nobile
25g, radix scutellariae 20g, Radix Notoginseng 17.5g, ganoderma lucidum 25g, radix paeoniae rubra 17.5g, Radix Rehmanniae 17.5g, Habenaria Ciliolaris Kranzl 35g.
5. the Chinese herbal and crude drugs preparations of the treatment diabetes as described in any in claim 2-4, which is characterized in that the Chinese herbal medicine system
Agent means decoction for oral administration, powder, capsule or pill.
6. the Chinese herbal and crude drugs preparations for the treatment of diabetes as claimed in claim 5, which is characterized in that the decoction is made as follows
It is standby: to weigh each bulk pharmaceutical chemicals by weight, add water to heat after mixing each bulk pharmaceutical chemicals, high fire is boiled to boiling, then uses small fire
Tanning 30 minutes, the strainer filtering by the medical fluid after tanning through 100 mesh, repeat the above steps decoction 3 times, merging filtrate to get.
7. the Chinese herbal and crude drugs preparations for the treatment of diabetes as claimed in claim 6, which is characterized in that the total weight of each bulk pharmaceutical chemicals
Ratio with the weight of water is 1:5-10.
8. the Chinese herbal and crude drugs preparations for the treatment of diabetes as claimed in claim 5, which is characterized in that the pill is made as follows
It is standby: each bulk pharmaceutical chemicals are weighed by weight to be crushed after mixing, be sieved to obtain medicinal powder of the partial size less than 0.03mm, pill is then made,
By pill dry to get.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1331990A (en) * | 2001-05-23 | 2002-01-23 | 郑国芃 | Chinese medicine for treating diabetes |
| CN104324244A (en) * | 2014-09-29 | 2015-02-04 | 刘方旭 | Compound dendrobium candidum blood-glucose-reducing capsule |
| CN106692789A (en) * | 2017-03-01 | 2017-05-24 | 贵州都匀市剑江药业有限公司 | Traditional Chinese medicinal composition for preventing and/or treating diabetes and preparation method thereof |
-
2019
- 2019-01-25 CN CN201910074545.XA patent/CN109692277A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1331990A (en) * | 2001-05-23 | 2002-01-23 | 郑国芃 | Chinese medicine for treating diabetes |
| CN104324244A (en) * | 2014-09-29 | 2015-02-04 | 刘方旭 | Compound dendrobium candidum blood-glucose-reducing capsule |
| CN106692789A (en) * | 2017-03-01 | 2017-05-24 | 贵州都匀市剑江药业有限公司 | Traditional Chinese medicinal composition for preventing and/or treating diabetes and preparation method thereof |
Non-Patent Citations (6)
| Title |
|---|
| 周现军: "降糖灵1号降血糖的实验研究", 《邯郸医学高等专科学校学报》 * |
| 张德贵等: "调肝滋肾法治疗2型糖尿病50例疗效观察", 《山西中医》 * |
| 李彬斐等: "詹学斌应用益气活血法治疗疑难杂症临证举隅", 《实用中医内科杂志》 * |
| 李新兰: "2型糖尿病胰岛素抵抗从虚从瘀论治浅探", 《辽宁中医杂志》 * |
| 胡艳平: "中西医结合治疗Ⅱ型糖尿病82例", 《湖北中医杂志》 * |
| 魏功昌: "三消合一汤治疗糖尿病42例", 《陕西中医》 * |
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Application publication date: 20190430 |