CN109674910A - It is a kind of to treat rhinitis drug and preparation method thereof - Google Patents

Abstract

The invention belongs to the technical field of traditional Chinese medicine and Chinese medicine, and discloses a medicine for treating rhinitis and a preparation method thereof. It is composed of 5-15 parts of Chuanxiong, 3-5 parts of Asarum, 10-20 parts of Shuanghua, 10-30 parts of Ephedra, 10-30 parts of Xinyi, 10-30 parts of Xanthium and 5-20 parts of Shichangpu. The inhaler can directly reach the affected area, give full play to the maximum effect of the drug, and immediately relieve symptoms such as nasal congestion and runny nose that make the patient feel the most uncomfortable. The invention adopts the ancient external medicine sneezing method and is developed by combining modern medical pharmacological research, and has obvious clinical effect. Clinical evaluation was carried out according to the following efficacy criteria. Invalid: nasal congestion, nasal itching, paroxysmal sneezing and runny nose and other symptoms did not change; effective: symptoms were alleviated; markedly effective: symptoms improved significantly.

Description

It is a kind of to treat rhinitis drug and preparation method thereof

Technical field

The invention belongs to field of traditional Chinese medicine technology more particularly to a kind of treat rhinitis drug and preparation method thereof.

Background technique

Currently, the prior art commonly used in the trade is such that

Rhinitis refers to the inflammation of nasal membrane and submucous tissue, and clinical manifestation is bronchia mucosal hyperemia, oedema, suffers from Person feels nasal obstruction, flows clear water tears, and rhiocnesmus, throat is uncomfortable, symptoms or even a large amount of nasal mucus of nasal cavity endocrine such as cough, due to infection It turns yellow, is flowed out through prenaris.

Rhinitis has chronic simple rhinitis, chronic hypertrophic rhinitis, caseous for the pathological change of nasal membrane Rhinitis, atrophic rhinitis etc.；From the urgency of morbidity is slow and the length of the course of disease for, acute rhinitis and rhinitis chronic can be divided into.In addition, Still there is the specific nosogenetic rhinitis such as allergic rhinitis (that is, allergic rhinitis), rhinitis medicamentosa.

Acute rhinitis is mostly to be commonly called as " catching cold " or " flu " caused by acute infection, can have constitutional symptom, with autumn and winter or Winter-Spring The friendship in season is common, and the course of disease 7~14 days, resistance powerhouse can self-healing.This disease should aim at prevention, and illness informal dress is clearing heat and detoxicating at present 1% ephedrine liquid of drug or intranasal drop, takes sulfa drug or antibiotic when necessary.

Rhinitis chronic is common frequently-occurring disease, often developed by acute rhinitis be not thorough with treatment, recurrent exerbation it is related. Rhinitis chronic is the chronic inflammation of nasal membrane and submucosa, and less serious case is known as pure rhinitis chronic, and severe one is referred to as hypertrophica Rhinitis, symptom is mainly nose alternately or duration blocks sense, nasal secretions.Clinically used treatment is intranasal drop Enter vasoconstrictor, such as 1% ephedrine can improve the ventilation of nasal cavity and drainage, make inflammatory resolution.It can be in concha nasalis inferior compared with severe one Submucosal injections curing agent can also make fulguration or cold therapy to improve ventilation, and the concha of proliferative fraction need to be made hand by serious person Art excision.

Allergic rhinitis is symptom and flu phase caused by nasal membrane is highly sensitive to certain ingredients in sucking air Seemingly, but in one day it can repeatedly break out, symptom rapidly disappears after alleviation.The breaking-out of allergic rhinitis has apparent seasonal.

Rhinitis morbidity harm is larger, will appear respiratory disorder when serious, and causing blood oxygen concentration reduces, influence other tissues and The function of organ and some such as headaches, dizzy, decrease of memory of metabolism appearance, pectoralgia, uncomfortable in chest, listlessness etc., or even can be simultaneously Send out the severe complications such as asthma.Rhinitis fails to get timely medical treatment, it is possible that dysosmia.As urban life is increasingly existing Dai Hua, vehicle exhaust, cosmetics, ornament materials and food additives etc., which become, causes rhinitis (including allergic rhinitis, chronic nose Inflammation, chronic nasosinusitis etc.) the main reason for.The number for suffering from rhinitis at present is more and more, and the age tends to become younger, therefore nose Scorching prevention and treatment can not be ignored.

In conclusion problem of the existing technology is:

(1) for the treatment of acute and chronic rhinitis, at present mostly with antibiotic, hormone medicine, vasoconstrictor treatment, temporary solution It does not effect a permanent cure, it is difficult to solve the problems, such as recurrent exerbation, and adverse reaction is more.

(2) clinical symptoms of rhinitis morbidity are different, and very harmful, obstinate easily induces various complication, serious shadow Ring daily life.

(3) under the living condition modernized, the inducement for causing rhinitis is more and more, and the age of patients with rhinitis tends to low age Change, patient populations increase year by year.

(4) traditional Chinese medicine prescription decocts inconvenient, and poor in timeliness cannot solve the symptoms such as patient's nasal congestion at once, cause It is acceptable poor.

Summary of the invention

In view of the problems of the existing technology, it provides and a kind of treats rhinitis drug inhalant and preparation method thereof.

The invention is realized in this way a kind of treat rhinitis drug, the treatment rhinitis drug is according to mass fraction by soap Angle 5-15 parts, 10-40 parts of muskmelon pedicel, 10-20 parts of the root of Dahurain angelica, 5-15 parts of Rhizoma Chuanxiong, 3-5 parts of asarum, 10-20 parts of honeysuckle, Chinese ephedra 10-30 Part, 10-30 parts of the flower bud of lily magnolia, 10-30 parts of the achene of Siberian cocklebur and 5-20 parts of rhizoma acori graminei compositions.

Another object of the present invention is to provide a kind of preparation method for the treatment of rhinitis drug, the treatment drug for treating rhinitis The preparation method of object the following steps are included:

Step 1,5-15 parts of gleditsia sinensis, 10-40 parts of muskmelon pedicel, 10-20 parts of the root of Dahurain angelica, 5-15 parts of Rhizoma Chuanxiong, 3-5 parts of asarum, honeysuckle 10-20 parts, 10-30 parts of Chinese ephedra, 5-20 parts of 10-30 parts of the flower bud of lily magnolia, 10-30 parts of the achene of Siberian cocklebur and rhizoma acori graminei finely ground powder cross hundred meshes, it is standby With；

Step 2,5-15 parts of gleditsia sinensis, 10-40 parts of muskmelon pedicel, 10-20 parts of the root of Dahurain angelica, 5-15 parts of Rhizoma Chuanxiong, 3-5 parts of asarum, honeysuckle 10-20 parts, 10-30 parts of Chinese ephedra, 10-30 parts of the flower bud of lily magnolia, 10-30 parts of the achene of Siberian cocklebur and 5-20 parts of rhizoma acori graminei drying；

Step 3: by said medicine high-temperature sterilization；

Step 4: using medicinal herb grinder, crush all drugs, is broken into fine particle, crosses hundred meshes；

Step 5: above-mentioned medicinal powder is uniformly mixed, packaging, is saved at dry and ventilated.

Further, the treatment medicament for treating rhinitis takes in 0.3-0.5 parts of sucking noses of medicinal powder, once a week or twice.

In conclusion advantages of the present invention and good effect are as follows: the present invention takes the method for sneezing using ancient times external drug, in conjunction with existing It is developed for medical pharmacology research, clinical effectiveness is obvious.Carry out clinical evaluation according to following criterion of therapeutical effect.It is invalid: nasal obstruction, nose Itch, paroxysmal sneezes and flows the symptoms such as clear nasal mucus and do not change；Effective: symptom is mitigated；Effective: symptom is obviously good Turn.

Tired observation rhinitis case 57 of clinic codeposition at present, significant effect.41 (71.93%) of recovery from illness, effective 12 (21.05%), invalid 4, for total effective rate up to 92.98%, Most patients Immediate effects are obvious, medication takes sneeze after feel logical Freely, be used in conjunction symptom three times it is substantially reduced in addition disappear.

Modern medical research has found that aromatics drug mostly contains fragrant terpene containing oxygen derivative or volatile oil, these objects Matter is mainly absorbed and used via the lipid channel of nasal epithelial cells and the aqueous duct of iuntercellular after entering nasal cavity, into Enter body circulation.Because of rich blood vessel in schneiderian membrance, permeability is high, thus the drug energy useful effect of via intranasal application administration in whole body and Degree of absorption, speed are suitable with intravenous injection.Especially drug of the relative molecular weight less than 1000, fat-soluble medicine are easier to by nose Mucosal absorption or even certain drugs absorbed difficult in the gastrointestinal tract can be through Nasal mucosa absorptions.There is warp in the drug of via intranasal application intake Regio olfactoria transhipment directly affects corticocerebral special pathway around blood-brain barrier, these are all to take the weight for sneezing method disease preventing and treating Want mechanism.

Since inhalant can go directly affected part, rapid-onset, fluent mechanism of qi, expelling pathogenic factors from muscles and skin eliminating evil, clearance are had one's ideas straightened out, are alleviated at once most Make the symptoms such as the nasal congestion of the patient feels discomfort, therefore treating both manifestation and root cause of disease, easy to use, dosage is few, safely and effectively and not When arresting.

Detailed description of the invention

Fig. 1 is the preparation method flow chart for the treatment of rhinitis drug provided in an embodiment of the present invention.

Specific embodiment

In order to make the objectives, technical solutions, and advantages of the present invention clearer, with reference to embodiments, to the present invention It is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, it is not used to Limit the present invention.

In present invention composition, based on gleditsia sinensis, muskmelon pedicel, the warm-natured acrid flavour of gleditsia sinensis has the function for eliminating the phlegm of having one's ideas straightened out；Muskmelon pedicel is used as and urges Vomitory, nasal cavity sucking then plays the role of promoting nasal mucus discharge, and muskmelon pedicel clearing away damp-heat water pouring is wet, and the medication of nasal cavity portion, which also has in treatment nose, to cease The effect of meat；Root of Dahurain angelica wind-damp dispelling, apocenosis of invigorating blood circulation, Rhizoma Chuanxiong blood-activating and qi-promoting, the two share promoting blood circulation clearing damp；Asarum, which has, has one's ideas straightened out The effect of wind-dispelling；Honeysuckle antipyretic and antidote functions are quite strong, are common product in surgery；It is anti-that modern pharmacology shows that Chinese ephedra has Scorching antianaphylactic effect；The classical medicine pair of the flower bud of lily magnolia, the achene of Siberian cocklebur as treatment rhinitis, the convergence to hypertrophic rhinitis and acute rhinitis Effect is apparent；The pungent dry temperature of hardship of opening of rhizoma acori graminei is led to, and fragrance is walked to alter, and not only has the function of inducing resuscitation of having one's ideas straightened out, and have both dampness elimination, and slit phlegm is warded off The benefits of dirty.

Application principle of the invention is explained in detail with reference to the accompanying drawing.

Treatment rhinitis drug provided in an embodiment of the present invention is according to mass fraction by 5-15 parts of gleditsia sinensis, 10-40 parts of muskmelon pedicel, white 10-20 parts of the root of Dahurian angelica, 5-15 parts of Rhizoma Chuanxiong, 3-5 parts of asarum, 10-20 parts of honeysuckle, 10-30 parts of Chinese ephedra, 10-30 parts of the flower bud of lily magnolia, achene of Siberian cocklebur 10- 30 parts and rhizoma acori graminei 5-20 parts compositions.

As shown in Figure 1, it is provided in an embodiment of the present invention treatment rhinitis drug preparation method the following steps are included:

S101: 5-15 parts of gleditsia sinensis, 10-40 parts of muskmelon pedicel, 10-20 parts of the root of Dahurain angelica, 5-15 parts of Rhizoma Chuanxiong, 3-5 parts of asarum, honeysuckle 10- 20 parts, 10-30 parts of Chinese ephedra, 5-20 parts of 10-30 parts of the flower bud of lily magnolia, 10-30 parts of the achene of Siberian cocklebur and rhizoma acori graminei finely ground powder cross hundred meshes, it is spare；

S102: 5-15 parts of gleditsia sinensis, 10-40 parts of muskmelon pedicel, 10-20 parts of the root of Dahurain angelica, 5-15 parts of Rhizoma Chuanxiong, 3-5 parts of asarum, honeysuckle 10- 20 parts, 10-30 parts of Chinese ephedra, 10-30 parts of the flower bud of lily magnolia, 10-30 parts of the achene of Siberian cocklebur and 5-20 parts of rhizoma acori graminei drying；

S103: by said medicine high-temperature sterilization；

S104: using medicinal herb grinder, crush all drugs, is broken into fine particle, crosses hundred meshes；

S105: above-mentioned medicinal powder is uniformly mixed, packaging, is saved at dry and ventilated.

Further, the treatment medicament for treating rhinitis takes in 0.3-0.5 parts of sucking noses of medicinal powder, once a week or twice.It will be above-mentioned Medicinal powder is uniformly mixed, packaging, is saved at dry and ventilated.In use, taking in appropriate (about 0.3-0.5 parts) the sucking nose of medicinal powder, weekly Once or twice.

Application effect of the invention is explained in detail below with reference to Pharmacological Analysis.

Gleditsia sinensis: Chinese honey locust has inhibiting effect to certain Gram-negative enteral pathogenic bacteria, and flooding agent (1:3) is right in test tube Certain dermatophytes also have inhibiting effect.Gleditsia sinensis can increase respiratory mucus secretion, there is phlegm-dispelling functions.

Muskmelon pedicel: muskmelon pedicel has the function of enhancing immune function, contains Cueurbitacin BDE, different Cueurbitacin B, calabash in muskmelon pedicel The cyanogen glycoside active constituent such as reed bitter principle B2OD, glucopyranoside has irritation to mucous membrane, clinically makes frequently as powder With, take orally it is emetic, and external application sucking can then make nasal cavity flow out yellow juice.

The root of Dahurain angelica: root of Dahurain angelica decoction is to Escherichia coli, shigella dysenteriae, proteus, typhoid bacillus, paratyphosum Bacterium, green pus bar Bacterium, comma bacillus, Bacillus tuberculosis etc. have inhibiting effect.Experiment in vitro confirms Oxypeucedannin in vitro test contained by this product There is antibacterial action to 11 kinds of bacterial strains.

Rhizoma Chuanxiong: effective component is ligustrazine, ferulic acid, Ligustilide etc., has contact smooth muscle spasm, expands blood vessel, Effect promoting blood circulation and removing obstruction in channels.

Asarum: Herba Asari volatile oil, which is gavaged or injected, apparent anti-inflammatory effect.If asarum is to proinflammatory agent carrageenan, ferment Rat articular swelling caused by mother, egg white, formaldehyde etc. has apparent inhibiting effect, and can fight croton oil induced mice swelling of auricle It is swollen, inhibit rat skin edema caused by antiserum and the capillary permeability as caused by histamine to increase.Asarum it is effective at Point methyl eugenol, four acrylamide of N- isobutyl group dodecane and demethyl coclaurine can obviously inhibit mouse caused by histamine from Body ileum contraction.Asarum water or alcohol extracting thing can make the total Anaphylactic mediator burst size of anaphylactic type reduce 40% or more, Illustrate that it has anti-allergy action.

Honeysuckle: having resisting pathogenic microbes effect, anti-inflammatory and refrigeration function, and the function that strengthens the defense effect can promote white The phagocytic function of cell can be obviously promoted inflammatory cell phagocytic function.

Chinese ephedra: effective component pseudoephedrine, methylephedrine, the ephedrine of Chinese ephedra, it can be by inhibiting allergy mediator to release It puts to realize anti-inflammatory antianaphylactic effect, and Chinese ephedra can be such that hemolysin reduces, and anti-inflammatory antiallergy is realized in anticomplementary action.

The flower bud of lily magnolia: modern medicine study shows to be clinically used for treating containing there are many effective component of anti-allergic effects in the flower bud of lily magnolia The diseases such as allergic rhinitis, asthma, anaphylactoid purpura.Flower bud of lily magnolia list medicine can reduce histamine release of mast cell, play bright Aobvious anti-inflammatory, anti-allergic effects.

The achene of Siberian cocklebur: diterpene hydroxy acid atractyloside contained by the achene of Siberian cocklebur has anti-inflammatory effect, and achene of Siberian cocklebur decoction is in vitro to golden yellow Staphylococcus has certain bacteriostasis, and acetone or alcohol extract also has bacteriostasis to Trichophyton rubrum in vitro.

Rhizoma acori graminei: the pungent dry temperature of hardship of opening of rhizoma acori graminei is led to, and fragrance is walked to alter, and not only has the function of inducing resuscitation of having one's ideas straightened out, and have both dampness elimination, slits Phlegm wards off the benefits of dirty.

Concrete application case study on implementation is explained in detail application effect of the invention below.

Liu, in November, 2017 is medical, and 53 years old, nasal congestion was repeatedly uncomfortable, makes a definite diagnosis rhinitis chronic more than 2 years.Existing disease are as follows: Nasal congestion, when have dizziness headache, stimulate in case of cold air, when have sneezing.Fear of wind, easy sweating.Once antibiotic, rhinitis were taken The drugs such as health piece, are only capable of respite, and long-term effect is unobvious.Then the rhinitis inhalant is used, in seconds continuous sneeze, then A large amount of yellow liquid outflows, 1 week twice.Follow-up after 2 weeks, feedback effects are obvious, and symptom is relieved, and without discomfort.Half Follow-up after year, Rhinitis Symptoms disappear substantially, no obvious adverse reaction.

The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention Made any modifications, equivalent replacements, and improvements etc., should all be included in the protection scope of the present invention within mind and principle.

Claims (3)

1. a kind of treat rhinitis drug, which is characterized in that the treatment rhinitis drug is according to mass fraction by 5-15 parts of gleditsia sinensis, melon 10-40 parts of the base of a fruit, 10-20 parts of the root of Dahurain angelica, 5-15 parts of Rhizoma Chuanxiong, 3-5 parts of asarum, 10-20 parts of honeysuckle, 10-30 parts of Chinese ephedra, flower bud of lily magnolia 10-30 Part, 10-30 parts of the achene of Siberian cocklebur and 5-20 parts of rhizoma acori graminei compositions.

2. a kind of preparation method of the rhinitis drug for the treatment of as described in claim 1, which is characterized in that the treatment rhinitis drug Preparation method the following steps are included:

Step 1,5-15 parts of gleditsia sinensis, 10-40 parts of muskmelon pedicel, 10-20 parts of the root of Dahurain angelica, 5-15 parts of Rhizoma Chuanxiong, 3-5 parts of asarum, honeysuckle 10-20 5-20 parts of part, 10-30 parts of Chinese ephedra, 10-30 parts of the flower bud of lily magnolia, 10-30 parts of the achene of Siberian cocklebur and rhizoma acori graminei finely ground powder cross hundred meshes, spare；

Step 2,5-15 parts of gleditsia sinensis, 10-40 parts of muskmelon pedicel, 10-20 parts of the root of Dahurain angelica, 5-15 parts of Rhizoma Chuanxiong, 3-5 parts of asarum, honeysuckle 10-20 Part, 10-30 parts of Chinese ephedra, 10-30 parts of the flower bud of lily magnolia, 10-30 parts of the achene of Siberian cocklebur and 5-20 parts of rhizoma acori graminei drying；

Step 3: by said medicine high-temperature sterilization；

Step 4: using medicinal herb grinder, crush all drugs, is broken into fine particle, crosses hundred meshes；

Step 5: above-mentioned medicinal powder is uniformly mixed, packaging, is saved at dry and ventilated.

3. the preparation method for the treatment of rhinitis inhalant as claimed in claim 2, which is characterized in that the treatment medicament for treating rhinitis takes In 0.3-0.5 parts of sucking noses of medicinal powder, once a week or twice.