CN109620224B - Electron paramagnetic imager - Google Patents
Electron paramagnetic imager Download PDFInfo
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- CN109620224B CN109620224B CN201910024007.XA CN201910024007A CN109620224B CN 109620224 B CN109620224 B CN 109620224B CN 201910024007 A CN201910024007 A CN 201910024007A CN 109620224 B CN109620224 B CN 109620224B
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- pair
- main magnet
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/0507—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves using microwaves or terahertz waves
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- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Radiology & Medical Imaging (AREA)
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- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
Abstract
The present invention is electron paramagnetic imager, including sample container, fast scanning resonant device, a pair of of fast line circle, a pair of of main magnet, a pair of of gradient magnet, main magnet driver, gradient magnet driver, fast line circle driver, microwave source, power amplifier, signal amplifier, fast digitizing instrument and computer.Signal of the invention is directly recorded by fast digitizing instrument, is had many advantages, such as that signal-to-noise ratio is high, data acquisition time is short, the distribution of high-power input, the Frequency Adjustable present invention according to sample signal in space, is reconstructed the 2D image of tumour.Working frequency of the invention is low frequency 250MHz or so, and electron paramagnetic imager can measure mouse tumor model and human body, and microwave permeability is preferable, and measurement range is relatively large, without operating on.
Description
Technical field
The present invention relates to electron paramagnetic technical field of imaging, are a kind of electron paramagnetic imagers.
Background technique
Electron paramagnetic resonance abbreviation EPR is the scientific skill of very powerful a research freedom base and metal electron structure
Art.The theoretical foundation of this technology " Zeemen effect " famous in physics, that is, electron energy level generates in magnetic field
Division.Electron paramagnetic resonance is observed by former Soviet Union scientist Panos Zavos base for the first time in nineteen forty-four.
The mechanism for having the ability to carry out electron paramagnetic resonance measurement domestic at present is detected in University Scientific Research unit, not yet spreads to
Other industry such as medical institutions.The all imports of instrument of electron paramagnetic experiment are carried out at present, and can only carry out high frequency measurement
9GHz or more can only measure sample signal, cannot be imaged.Domestic not yet someone uses technique to animal model；The world
On not yet someone technique is used to clinic.Traditional measurement uses continuous wave method, ineffective for low concentration sample,
And time of measuring is longer.
Summary of the invention
The present invention is to solve the above problems, provide a kind of electron paramagnetic imager, the present invention provides following technical sides
Case:
A kind of electron paramagnetic imager, including sample container, fast scanning resonant device, a pair of of fast line circle, a pair
Main magnet, a pair of of gradient magnet, main magnet driver, gradient magnet driver, fast line circle driver, microwave source, function
Rate amplifier, signal amplifier, fast digitizing instrument and computer；
Main magnet driver one end connects main magnet, and gradient magnet driver one end connects gradient magnet, fast line
It encloses driver one end and connects fast line circle, place sample container among fast scanning resonant device, fast scanning resonant device is same
When connect one end of power amplifier and signal amplifier, the other end of power amplifier connects microwave source, signal amplifier
The other end connects fast digitizing instrument, main magnet driver, gradient magnet driver, fast line circle driver, microwave source
It is connect with computer with fast digitizing instrument, fast scanning resonant device two sides are close to a pair of of fast line circle, described
The outside of a pair of of fast line circle is equipped with a pair of of gradient magnet, and a pair of of main magnet is equipped on the outside of the pair of gradient magnet,
Fast scanning resonant device connection, the pair of main magnet inner ring are distributed several coil suspensions and positioning system, and described one
There are several coil suspensions to support main magnet lower part, coil suspension is fixed by the bracket, and is connected between the bracket by the way that rivet is fixed
It connects, the fast scanning resonant device is placed among main magnet by individual positioning system and coil suspension support；
The pair of main magnet inner ring is distributed several coil suspensions and positioning system, the pair of main magnet with a thickness of
10cm, width 8cm, the pair of main magnet horizontal space are 60cm, and several coil suspensions are arranged at the pair of main magnet lower part
Support, coil suspension are fixed by the bracket, and adjacent stent is fixed by rivet.
Preferably, the pair of main magnet is with a thickness of 10cm, width 8cm, and the pair of main magnet horizontal space is
60cm, the pair of main magnet overall diameter are 160cm, interior diameter 140cm.
Preferably, the main magnet and gradient magnet are the electromagnet of a coil winding, big by control electric current
It is small to reach required magnetic field strength；
Preferably, the bracket and rivet are fiberglass-reinforced plastic, are a kind of insulators.
Preferably, the sample container is quartz test tube or 3D printing plastics.
Preferably, microwave source uses VHF wave band, and frequency range is 250MHz to 265MHz.
Preferably, the fast line circle driver is LC oscillating circuit, is quickly swept by the adjusting change of capacitor
Retouch frequency.
Preferably, distribution of the electron paramagnetic imager according to sample signal in space reconstructs the 2D image of tumour.
Preferably, the measurement effective volume region of the electron paramagnetic imager is the sphere greater diameter than 30cm, institute
The central point for stating sphere is located at the center of the electron paramagnetic imager.
The invention has the following advantages:
Signal of the invention is directly recorded by fast digitizing instrument, with signal-to-noise ratio is high, data acquisition time is short, big function
Distribution of the present invention according to sample signal in space of the advantages that rate input, Frequency Adjustable, reconstructs the 2D image of tumour.
Working frequency of the invention is low frequency 250MHz or so, and electron paramagnetic imager can be to mouse tumor model and people
Body measures, and microwave permeability is preferable, and measurement range is relatively large, without operating on.
Detailed description of the invention
Fig. 1 is electron paramagnetic imager structure chart.
Fig. 2 is primary magnet structure figure.
Fig. 3 is electron paramagnetic imager simulation drawing.
Specific embodiment
Below in conjunction with specific embodiment, describe the invention in detail.
Specific embodiment one:
According to Fig. 1 and Fig. 2: a kind of electron paramagnetic imager, including sample container, fast scanning resonant device, a pair
Fast line circle, a pair of of main magnet, a pair of of gradient magnet, main magnet driver, gradient magnet driver, fast line circle
Driver, microwave source, power amplifier, signal amplifier, fast digitizing instrument and computer；
Main magnet driver one end connects main magnet, and gradient magnet driver one end connects gradient magnet, fast line
It encloses driver one end and connects fast line circle, fast scanning resonant device connects sample container, and sample container connects power simultaneously
One end of amplifier and signal amplifier, the other end of power amplifier connect microwave source, the other end connection of signal amplifier
Fast digitizing instrument, main magnet driver, gradient magnet driver, fast line circle driver, microwave source and fast digital
Change instrument to connect with computer, fast scanning resonant device two sides are quickly swept close to a pair of of fast line circle the pair of
The outside for retouching coil is equipped with a pair of of gradient magnet, and a pair of of main magnet is equipped on the outside of the pair of gradient magnet, described quickly to sweep
Resonator connection is retouched, the pair of main magnet inner ring is distributed several coil suspensions and positioning system, under the pair of main magnet
Portion has several coil suspensions to support, and coil suspension is fixed by the bracket, is fixedly connected between the bracket by rivet；
Sample container can be quartz test tube or the 3D printing plastics of the arbitrary shape of customization.Fast scanning resonant device is
The region of sample generation RESONANCE ABSORPTION.The fast scanning resonant device is placed by individual positioning system and coil suspension support
Among main magnet.Main magnet and gradient magnet are coil winding electromagnet, reach required by controlling size of current
Magnetic field strength.Fast line circle and driver, principle are LC oscillating circuit, change quick scanning by the adjusting of capacitor
Frequency.The energy size of microwave input is adjusted in microwave source, uses VHF wave band, i.e. 250MHz to 265MHz or so.Power amplification
Device is used for excitation pulse, for that can significantly increase signal strength compared with weak sample.Main magnet and the selection of gradient magnet driver can
Commercialized power supply is bought, digitizer, power supply, power amplifier etc. can buy commercially produced product, other special low frequencies are set
Meter component such as magnet, resonator etc. needs self design.
The pair of main magnet inner ring is distributed several coil suspensions and positioning system, the pair of main magnet with a thickness of
10cm, width 8cm, the pair of main magnet horizontal space are 60cm, and several coil suspensions are arranged at the pair of main magnet lower part
Support, coil suspension are fixed by the bracket, and adjacent stent is fixed by rivet.
The pair of main magnet is with a thickness of 10cm, and width 8cm, the pair of main magnet horizontal space is 60cm, described
A pair of of main magnet overall diameter is 160cm, interior diameter 140cm.Main magnet coiling uses copper conductor 2.78 × 0.019 (thickness),
Every layer is enclosed around one, and 200 layers altogether.Main magnet parameter is as shown in the table:
Main magnet parameter
| Wire size | National standard 33.6mm2 |
| Coil resistance | 0.8Ω |
| Electric current | 40A |
| Power | 1150W |
| Quality | 666kg |
The measurement effective volume region of electron paramagnetic imager is the sphere greater diameter than 30cm, the center of the sphere
Point is located at the center of the electron paramagnetic imager.Continuous magnetic field strength is 0.009T, maximum magnetic field strength 0.014T,
Homogeney is that error is ± 40ppm on 30cm.The channel of the measurement effective volume of electron paramagnetic imager is that axial diameter is about
50-60cm, longitudinal diameter are about 30cm.
Instrument needs using special chemical example (i.e. probe) --- and free radical generates signal.Free radical can be purchased
It buys, it can also be with independent development synthesis and recovery train.Free-atom aqueous solution is safe and non-toxic, metabolism is fast.
The above is only the preferred embodiment of electron paramagnetic imager, and the protection scope of electron paramagnetic imager is not
It is limited only to above-described embodiment, all technical solutions belonged under thinking all belong to the scope of protection of the present invention.It should be pointed out that for
For those skilled in the art, several improvements and changes without departing from the principles of the present invention, these improve and
Variation also should be regarded as protection scope of the present invention.
Claims (9)
1. a kind of electron paramagnetic imager, it is characterized in that: including sample container, fast scanning resonant device, a pair of of fast line
It is circle, a pair of of main magnet, a pair of of gradient magnet, main magnet driver, gradient magnet driver, fast line circle driver, micro-
Wave source, power amplifier, signal amplifier, fast digitizing instrument and computer；
Main magnet driver one end connects main magnet, and gradient magnet driver one end connects gradient magnet, and fast line circle drives
Dynamic device one end connects fast line circle, places sample container among fast scanning resonant device, sample container connects power simultaneously
One end of amplifier and signal amplifier, the other end of power amplifier connect microwave source, the other end connection of signal amplifier
Fast digitizing instrument, main magnet driver, gradient magnet driver, fast line circle driver, microwave source and fast digital
Change instrument to connect with computer, fast scanning resonant device two sides are quickly swept close to a pair of of fast line circle the pair of
The outside for retouching coil is equipped with a pair of of gradient magnet, and a pair of of main magnet is equipped on the outside of the pair of gradient magnet, described quickly to sweep
Resonator connection sample container is retouched, the pair of main magnet inner ring is distributed several coil suspensions and positioning system, the pair of
Main magnet lower part has several coil suspensions to support, and coil suspension is fixed by the bracket, is fixedly connected between the bracket by rivet,
The fast scanning resonant device is placed among main magnet by individual positioning system and coil suspension support；
The pair of main magnet inner ring is distributed several coil suspensions and positioning system, the pair of main magnet with a thickness of 10cm,
Width is 8cm, and the pair of main magnet horizontal space is 60cm, and the pair of main magnet lower part has several coil suspensions to support,
Coil suspension is fixed by the bracket, and adjacent stent is fixed by rivet.
2. a kind of electron paramagnetic imager according to claim 1, it is characterized in that: the pair of main magnet with a thickness of
10cm, width 8cm, the pair of main magnet horizontal space are 60cm, and the pair of main magnet overall diameter is 160cm, interior straight
Diameter is 140cm.
3. a kind of electron paramagnetic imager according to claim 2, it is characterized in that: the main magnet and gradient magnet are
The electromagnet of one coil winding reaches required magnetic field strength by controlling size of current.
4. a kind of electron paramagnetic imager according to claim 1, it is characterized in that: the bracket and rivet are glass fibers
Reinforced plastics is tieed up, is a kind of insulator.
5. a kind of electron paramagnetic imager according to claim 1, it is characterized in that: the sample container be quartz test tube or
Person's 3D printing plastics.
6. a kind of electron paramagnetic imager according to claim 1, it is characterized in that: microwave source uses VHF wave band, frequency model
It encloses for 250MHz to 265MHz.
7. a kind of electron paramagnetic imager according to claim 1, it is characterized in that: the fast line circle driver is
LC oscillating circuit changes quick scan frequency by the adjusting of capacitor.
8. a kind of electron paramagnetic imager according to claim 1, it is characterized in that: the electron paramagnetic imager is according to sample
Product signal reconstructs the 2D image of tumour in the distribution in space.
9. a kind of electron paramagnetic imager according to claim 1, it is characterized in that: the measurement of the electron paramagnetic imager
Effective volume region is the sphere greater diameter than 30cm, and the central point of the sphere is located in the electron paramagnetic imager
At heart point.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910024007.XA CN109620224B (en) | 2019-01-10 | 2019-01-10 | Electron paramagnetic imager |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910024007.XA CN109620224B (en) | 2019-01-10 | 2019-01-10 | Electron paramagnetic imager |
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| CN109620224A CN109620224A (en) | 2019-04-16 |
| CN109620224B true CN109620224B (en) | 2019-11-05 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| EP3875980B1 (en) * | 2020-03-03 | 2022-08-10 | Bruker France S.A.S. | Mechanical apparatus for fast epr coils switching between rapid scan and cw modes |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4719425A (en) * | 1986-04-15 | 1988-01-12 | Scientific Innovations, Inc. | NMR imaging method and apparatus |
| GB8909270D0 (en) * | 1989-04-24 | 1989-06-07 | Hafslund Nycomed Innovation | Method |
| GB9216597D0 (en) * | 1992-08-05 | 1992-09-16 | British Tech Group | Method of obtaining images representing the distribution of paramagnetic material in solution |
| US6504367B1 (en) * | 2000-09-01 | 2003-01-07 | Council Of Scientific And Industrial Research | Electronic paramagnetic resonance imaging device using high amplitude modulator |
| JP2005274167A (en) * | 2004-03-23 | 2005-10-06 | Jeol Ltd | Cavity resonator for esr |
| JP2005321367A (en) * | 2004-05-07 | 2005-11-17 | Shoichi Ri | Method for measuring free radical by esr |
| WO2007144890A1 (en) * | 2006-06-15 | 2007-12-21 | Technion Research & Development Foundation Ltd. | Probe and system for electron spin resonance imaging |
| JP5417619B2 (en) * | 2010-06-28 | 2014-02-19 | 国立大学法人 大分大学 | Electromagnetic horn type electron spin resonance (ESR) device |
| CN102879754B (en) * | 2012-09-19 | 2015-07-22 | 中国科学院电工研究所 | Magnetic field circulating device for proton/electron double resonance imaging |
| JP2018028534A (en) * | 2016-08-10 | 2018-02-22 | 公一 中川 | Melanin pigment radical measurement device |
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Effective date of registration: 20190924 Address after: Room 103-4, Building No. 7, 45 Yanxing Road, Nangang District, Harbin City, Heilongjiang Province, 150001 Applicant after: Harbin Characteristic Technology Development Co.,Ltd. Address before: 150090 Room 713, 178 Hongqi Street, Building 19, Nangang High-tech Enterprise Center, Nangang High-tech Industrial Development Zone, Harbin City, Heilongjiang Province Applicant before: HARBIN HUAAO NEW TECHNOLOGY DEVELOPMENT Co.,Ltd. |
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Address after: 8145-11, Building 18, Jintong International Industrial Park, No. 8 Xihu Road, Wujin National High tech Industrial Development Zone, Changzhou City, Jiangsu Province, 213100 Patentee after: Changzhou Characteristic Information Technology Co.,Ltd. Address before: Room 103-4, Building 7, No. 45 Yanxing Road, Nangang District, Harbin City, Heilongjiang Province, 150001 Patentee before: Harbin Characteristic Technology Development Co.,Ltd. |
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