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CN109602875B - Traditional Chinese medicine composition for treating infantile fever as well as preparation method and application thereof - Google Patents

Traditional Chinese medicine composition for treating infantile fever as well as preparation method and application thereof Download PDF

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CN109602875B
CN109602875B CN201910082024.9A CN201910082024A CN109602875B CN 109602875 B CN109602875 B CN 109602875B CN 201910082024 A CN201910082024 A CN 201910082024A CN 109602875 B CN109602875 B CN 109602875B
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帅云飞
李鑫
蔡萌
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Abstract

The invention discloses a traditional Chinese medicine composition for treating infantile fever, which is prepared from the following raw material medicines in percentage by weight: 5.00 to 6.38 percent of divaricate saposhnikovia root, 5.00 to 6.38 percent of wrinkled gianthyssop herb, 2.86 to 6.67 percent of fried gardenia, 25.00 to 28.57 percent of gypsum, 2.86 to 4.48 percent of liquorice, 17.91 to 22.86 percent of radix pseudostellariae, 8.51 to 10.00 percent of officinal magnolia bark, 10.64 to 15.00 percent of perilla leaf, 4.48 to 6.38 percent of fried radish seed and 4.48 to 6.38 percent of katsumade galangal seed. The prescription for treating infantile fever is added with radix pseudostellariae, mangnolia officinalis, perilla leaves, amomum tsao-ko and fried radish seeds on the basis of the diarrhea yellow powder prescription, so that the spleen and stomach are strengthened while the fever is abated, the fever abating effect is better, and the fever is not easy to relapse.

Description

Traditional Chinese medicine composition for treating infantile fever as well as preparation method and application thereof
Technical Field
The invention belongs to the technical field of medicines, and particularly relates to a traditional Chinese medicine composition for treating infantile fever, a preparation method and application thereof.
Background
Fever is one of the most common symptoms of pediatric infectious diseases, and fever caused by external infection of children is the most common. Fever in children can cause convulsion, dehydration and other complications, and seriously endangers the life safety of children patients. 70-80% of children with upper respiratory tract infection in pediatric outpatient clinic are clinically manifested by fever, cough and pharyngalgia, and fever in children is the main reason for emergency treatment in hospitals before.
Modern medicine considers that upper respiratory tract infection is caused by virus and bacteria infection, wherein the virus infection accounts for 80-90%, and the bacteria infection accounts for 10%. At present, bacterial fever has achieved satisfactory curative effects, but the curative effects are not significant enough in the aspect of clinical treatment of viral fever. At present, more antipyretic drugs such as analgin, paracetamol and the like are used, the problem of body temperature recovery after a short time of antipyresis exists, and the western medicines have adverse drug reactions which are unfavorable for the body.
Therefore, a batch of Chinese medicinal preparations such as Yinqiao antidotal pills, isatis root granules, Bupleurum chinensis granules, Yinhuang oral liquid and the like are published one after another, are widely applied to clinical treatment of infantile fever, and achieve a certain curative effect, but most of the Chinese medicaments are bitter and astringent and are difficult to swallow. The medicines are not scientifically prepared according to the patients of specific ages, children of different ages are distinguished only by controlling the taking amount, the family members of the children patients are difficult to accurately grasp and reasonably use, and the treatment effect cannot be achieved or some side effects are caused.
Disclosure of Invention
The invention aims to overcome the defects that the traditional Chinese medicine has bitter taste, children patients are difficult to swallow, and scientific proportioning is not carried out aiming at children of different age groups in the prior art, and provides a traditional Chinese medicine composition capable of effectively treating infantile fever.
The invention provides a traditional Chinese medicine composition for treating infantile fever, which is prepared from the following raw material medicines in percentage by weight: 5.00 to 6.38 percent of divaricate saposhnikovia root, 5.00 to 6.38 percent of wrinkled gianthyssop herb, 2.86 to 6.67 percent of fried gardenia, 25.00 to 28.57 percent of gypsum, 2.86 to 4.48 percent of liquorice, 17.91 to 22.86 percent of radix pseudostellariae, 8.51 to 10.00 percent of officinal magnolia bark, 10.64 to 15.00 percent of perilla leaf, 4.48 to 6.38 percent of fried radish seed and 4.48 to 6.38 percent of katsumade galangal seed.
Preferably, the traditional Chinese medicine composition for treating infantile fever is prepared from the following raw material medicines in percentage by weight: 5.71 percent of divaricate saposhnikovia root, 5.71 percent of wrinkled gianthyssop herb, 2.86 percent of fried gardenia, 28.57 percent of gypsum, 2.86 percent of liquorice, 22.86 percent of radix pseudostellariae, 8.57 percent of officinal magnolia bark, 11.44 percent of perilla leaf, 5.71 percent of fried radish seed and 5.71 percent of katsumade galangal seed.
Preferably, the traditional Chinese medicine composition for treating infantile fever is prepared from the following raw material medicines in percentage by weight: 6.38 percent of divaricate saposhnikovia root, 6.38 percent of wrinkled gianthyssop herb, 4.26 percent of fried gardenia, 25.53 percent of gypsum, 4.26 percent of liquorice, 21.28 percent of radix pseudostellariae, 8.51 percent of officinal magnolia bark, 10.64 percent of perilla leaf, 6.38 percent of fried radish seed and 6.38 percent of katsumade galangal seed.
Preferably, the traditional Chinese medicine composition for treating infantile fever is prepared from the following raw material medicines in percentage by weight: 5.66 percent of divaricate saposhnikovia root, 5.66 percent of wrinkled gianthyssop herb, 5.66 percent of fried gardenia, 28.30 percent of gypsum, 3.77 percent of liquorice, 18.87 percent of radix pseudostellariae, 9.44 percent of officinal magnolia bark, 11.32 percent of perilla leaf, 5.66 percent of fried radish seed and 5.66 percent of katsumade galangal seed.
Preferably, the traditional Chinese medicine for treating infantile fever is prepared from the following raw material medicines in percentage by weight: 5.45 percent of divaricate saposhnikovia root, 5.45 percent of wrinkled gianthyssop herb, 5.46 percent of fried gardenia, 27.27 percent of gypsum, 3.64 percent of liquorice, 18.18 percent of radix pseudostellariae, 9.09 percent of officinal magnolia bark, 14.55 percent of perilla leaf, 5.45 percent of fried radish seed and 5.46 percent of katsumade galangal seed.
Preferably, the traditional Chinese medicine composition for treating infantile fever is prepared from the following raw material medicines in percentage by weight: 5.00 percent of divaricate saposhnikovia root, 5.00 percent of wrinkled gianthyssop herb, 6.67 percent of fried gardenia, 25.00 percent of gypsum, 3.33 percent of liquorice, 20.00 percent of radix pseudostellariae, 10.00 percent of officinal magnolia bark, 15.00 percent of perilla leaf, 5.00 percent of fried radish seed and 5.00 percent of katsumade galangal seed.
Preferably, the traditional Chinese medicine composition for treating infantile fever is prepared from the following raw material medicines in percentage by weight: 5.97 percent of divaricate saposhnikovia root, 5.97 percent of wrinkled gianthyssop herb, 5.97 percent of fried gardenia, 26.87 percent of gypsum, 4.48 percent of liquorice, 17.91 percent of radix pseudostellariae, 8.95 percent of officinal magnolia bark, 14.92 percent of perilla leaf, 4.48 percent of fried radish seed and 4.48 percent of katsumade galangal seed.
The invention also provides a preparation method of the traditional Chinese medicine composition for treating infantile fever, which comprises the following steps: (1) taking 25.00-28.57% of gypsum, placing in a marmite or a stainless steel pot or a pottery pot or a crock or a drug decocting pot or a purple clay pot, soaking in water, boiling with strong fire, and decocting for 5-120 minutes first; (2) taking other traditional Chinese medicine raw materials in the formula according to the proportion of 5.00-6.38 percent of divaricate saposhnikovia root, 5.00-6.38 percent of wrinkled gianthyssop herb, 2.86-6.67 percent of fried gardenia, 2.86-4.48 percent of liquorice, 17.91-22.86 percent of radix pseudostellariae, 8.51-10.00 percent of magnolia officinalis, 10.64-15.00 percent of perilla leaf, 4.48-6.38 percent of fried radish seed and 4.48-6.38 percent of katsumade galangal seed, uniformly mixing, placing into a marmite or a stainless steel pot or a pottery pot or a crock or a decocting pot or a purple clay pot which has been decocted with raw gypsum, adding water to ensure that the volume mass ratio of the water to the traditional: 1g, boiling with strong fire, then decocting with slow fire, and filtering to obtain filtrate, namely the traditional Chinese medicine composition for treating infantile fever.
The invention also provides application of the traditional Chinese medicine composition for treating infantile fever in the aspect of treating infantile fever.
Although the alpinia katsumadai maxim in the application is applied to the treatment of infantile fever, the alpinia katsumadai maxim is applied to a bath formula for treating infantile fever caused by exogenous pathogenic factors, and is not applied to a traditional Chinese medicine for directly and orally taking the traditional Chinese medicine for treating infantile fever. Because, the routine knowledge of those skilled in the art is that children are in the process of continuous growth and development, whether in the aspects of body, physiology, pathology, etc., different from adults, the age is more obvious; therefore, if the traditional Chinese medicine raw materials are directly prepared into oral medicaments, side effects can be caused to patients, especially for patients with small ages, the dosage is difficult to control, and potential safety hazards exist. Therefore, at present, the traditional Chinese medicine materials are usually prepared into external preparations such as patches or bath agents, and are slowly absorbed by permeation through the skin surface. The alpinia katsumadai maxim in the application is matched with the medicines, the radix pseudostellariae, the mangnolia officinalis, the perilla leaves and the fried radish seeds in the prescription of the diarrhea yellow powder, and the corresponding raw material contents are adjusted according to children of different ages to obtain different formulas, so that fever of children of 0-18 years old can be treated. And when the dosage of the raw materials is adjusted for children of different ages, the dosage of all the raw materials is not adjusted to be larger or smaller, but the dosage of one or more raw materials is adjusted, and the raw materials adjusted each time are different, which indicates that the traditional Chinese medicine formula of the application is not randomly added or reduced when the traditional Chinese medicine formula is used for treating children fever patients of different ages, but the added or reduced objects and the added or reduced amounts of the raw materials are obtained through practice on the basis of a certain theory. The series of traditional Chinese medicines for treating infantile fever can be prepared by pertinently selecting a traditional Chinese medicine formula according to different ages of patients with infantile fever, so that the treatment effect is more remarkable, and the side effect is lower.
The application also adopts stir-fried radish seed, and although the radish seed is used for treating fever in children, the radish seed is not stir-fried. In Chinese medicinal herb decoction piece analysis and processing principle research (II), Jiajing, Shandong university of traditional Chinese medicine, discloses that the content and even the type of some ingredients of radish seed and fried radish seed are changed due to different processing methods, and the final efficacies are also different. The efficacy of stir-fried radish seed before being used mainly for promoting digestion, relieving flatulence, descending qi and reducing phlegm; can be used for treating food stagnation, abdominal pain, constipation, stagnation, dysentery, phlegm stagnation, and cough and asthma; the function of the radish seed in heat dissipation is not disclosed, so that the radish seed fried by the radish seed frying machine is used for treating infantile fever without motivation of a person skilled in the art, and the operation is more complicated.
The prescription for treating infantile fever is added with radix pseudostellariae, magnolia officinalis, perilla leaves, amomum tsao-ko and stir-fried radish seeds on the basis of the prescription of the diarrhea yellow powder. The diarrhea yellow powder is a traditional Chinese medicine prescription and mainly treats spleen and stomach fire syndrome, eye sore and halitosis, polydipsia and hunger, dry mouth and lips, red tongue and rapid pulse, spleen heat affecting tongue and the like. Although one or more raw materials in the prescription of the diarrhea Huangsan are used for treating the infantile fever at present, the whole prescription of the diarrhea Huangsan is not used for treating the infantile fever, the diarrhea Huangsan is used for removing the fire of the spleen and the stomach, the spleen and the stomach are usually easily injured by exogenous fever, if the fever is simply relieved, the fever is difficult to be relieved, the spleen and the stomach are further injured, and the reason that the existing antipyretic is easy to be reheated is also taken; therefore, the spleen and the stomach should be considered for treating the infantile fever, the fever-relieving medicine is forbidden to damage yang and to relieve the stomach due to bitter cold, the radix pseudostellariae, the magnolia officinalis, the perilla leaves, the amomum tsao-ko and the fried radish seeds are added on the basis of the diarrhea powder formula, the spleen and the stomach can be strengthened while the fever is relieved, the fever-relieving effect is better, and the relapse is not easy to occur.
The application inherits the concept of 'pathogenic fever, body encouraging healthy qi to resist pathogenic factors and generating heat image', and aims at the pathological characteristics of infantile fever, adopts a method of strengthening spleen and relieving stasis to circulate qi activity of the whole body. Has obvious curative effect and truly reflects 'treatment of disease and seeking the root cause'. The prescription of the application combines pungent, warm and cool medicines, children are easy to be cold and easy to be hot, cold changes from heat or heat changes into cold beams, and wind-cold and wind-heat are less common, and in treatment, the children are single pungent and warm, usually sweat and heat are subsided, but the children are easy to relapse; the single pungent and cool herb often sweats but cannot release exterior pathogens easily. While pungent, warm, pungent and cool in property, they can relieve both wind-cold and wind-heat, and the heat can be withdrawn without recovery.
The invention has the beneficial effects that:
1. the alpinia katsumadai maxim and the medicines in the diarrhea and jaundice treating powder prescription, the radix pseudostellariae, the mangnolia officinalis, the perilla leaves and the fried radish seeds are matched together, corresponding raw material contents are adjusted according to children of different ages to obtain different formulas, fever of 0-18 year old children can be treated, the alpinia katsumadai maxim can be used for treating fever caused by acute upper respiratory tract infection, gastrointestinal type cold, acute bronchitis, various infectious diseases and the like, and the effective rate is more than 98%.
2. The medicine raw materials are scientifically proportioned, and the corresponding raw material content is adjusted according to children of different ages to obtain different formulas, so that the medicine can treat fever of children of 0-18 years old.
3. The prescription for treating infantile fever is added with radix pseudostellariae, mangnolia officinalis, perilla leaves, amomum tsao-ko and fried radish seeds on the basis of the diarrhea yellow powder prescription, so that the spleen and stomach are strengthened while the fever is abated, the fever abating effect is better, and the fever is not easy to relapse.
4. The invention is prepared by extracting natural Chinese herbal medicines, does not use synthetic chemical raw materials, has low production cost, is safe, can be used for a long time, and has small toxic and side effects on human bodies.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to specific embodiments below.
Example 1
A traditional Chinese medicine composition for treating infantile fever is prepared from the following raw material medicines in percentage by weight: 5.71 percent of divaricate saposhnikovia root, 5.71 percent of wrinkled gianthyssop herb, 2.86 percent of fried gardenia, 28.57 percent of gypsum, 2.86 percent of liquorice, 22.86 percent of radix pseudostellariae, 8.57 percent of officinal magnolia bark, 11.44 percent of perilla leaf, 5.71 percent of fried radish seed and 5.71 percent of katsumade galangal seed.
The preparation method comprises the following steps:
(1) taking 10g of gypsum, placing in an earthenware pot or a stainless steel pot or a pottery pot or a crock or a drug decocting pot or a purple clay pot, adding 200ml of water for soaking, boiling with strong fire, and decocting for 5-120 minutes first; (2) 2g of divaricate saposhnikovia root, 2g of wrinkled gianthyssop herb, 1g of fried gardenia, 1g of liquorice, 8g of heterophylly falsestarwort root, 3g of officinal magnolia bark, 4g of perilla leaf, 2g of fried radish seed and 2g of katsumadai seed are uniformly mixed and placed in a marmite or a stainless steel pot or a pottery pot or a crock or a decocting pot or a purple clay pot which is used for decocting gypsum, water is added to 200ml, the mixture is soaked for 20 minutes, the mixture is boiled on fire with strong fire, then decocted on slow fire for 10 to 15 minutes, 60ml of liquid medicine is filtered, and the. The traditional Chinese medicine is suitable for children patients of 0-1 year old.
Example 2
A traditional Chinese medicine composition for treating infantile fever is prepared from the following raw material medicines in percentage by weight: 6.38 percent of divaricate saposhnikovia root, 6.38 percent of wrinkled gianthyssop herb, 4.26 percent of fried gardenia, 25.53 percent of gypsum, 4.26 percent of liquorice, 21.28 percent of radix pseudostellariae, 8.51 percent of officinal magnolia bark, 10.64 percent of perilla leaf, 6.38 percent of fried radish seed and 6.38 percent of katsumade galangal seed.
The preparation method comprises the following steps: (1) taking 12g of gypsum, placing in an earthenware pot or a stainless steel pot or a pottery pot or a crock or a drug decocting pot or a purple clay pot, adding 300ml of water for soaking, boiling with strong fire, and decocting for 5-120 minutes first; (2) 3g of divaricate saposhnikovia root, 3g of wrinkled gianthyssop herb, 2g of fried gardenia, 2g of liquorice, 10g of heterophylly falsestarwort root, 4g of officinal magnolia bark, 5g of perilla leaf, 3g of fried radish seed and 3g of katsumadai seed are uniformly mixed and placed in a marmite or a stainless steel pot or a pottery pot or a crock or a decocting pot or a purple clay pot which is used for decocting gypsum, water is added to 300ml, the mixture is soaked for 20 minutes, the mixture is boiled by strong fire firstly and then decocted by slow fire for 10 to 15 minutes, and 120ml of liquid medicine is filtered out and. The traditional Chinese medicine is suitable for children patients of 1-3 years old.
Example 3
A traditional Chinese medicine composition for treating infantile fever is prepared from the following raw material medicines in percentage by weight: 5.66 percent of divaricate saposhnikovia root, 5.66 percent of wrinkled gianthyssop herb, 5.66 percent of fried gardenia, 28.30 percent of gypsum, 3.77 percent of liquorice, 18.87 percent of radix pseudostellariae, 9.44 percent of officinal magnolia bark, 11.32 percent of perilla leaf, 5.66 percent of fried radish seed and 5.66 percent of katsumade galangal seed.
The preparation method comprises the following steps: (1) taking 15g of gypsum, placing the gypsum in an earthenware pot or a stainless steel pot or a pottery pot or a crock or a drug decocting pot or a purple clay pot, adding 300ml of water for soaking, boiling with strong fire, and decocting for 5-120 minutes first; (2) 3g of divaricate saposhnikovia root, 3g of wrinkled gianthyssop herb, 3g of fried gardenia, 2g of liquorice, 10g of heterophylly falsestarwort root, 5g of officinal magnolia bark, 6g of perilla leaf, 3g of fried radish seed and 3g of katsumadai seed are uniformly mixed and placed in a marmite or a stainless steel pot or a pottery pot or a crock or a decocting pot or a purple clay pot which is used for decocting gypsum, water is added to 300ml, the mixture is soaked for 20 minutes, the mixture is boiled by strong fire firstly and then decocted by slow fire for 10 to 15 minutes, 150ml of liquid medicine is filtered, and the. The traditional Chinese medicine is suitable for children patients of 3-6 years old.
Example 4
A traditional Chinese medicine composition for treating infantile fever is prepared from the following raw material medicines in percentage by weight: 5.45 percent of divaricate saposhnikovia root, 5.45 percent of wrinkled gianthyssop herb, 5.46 percent of fried gardenia, 27.27 percent of gypsum, 3.64 percent of liquorice, 18.18 percent of radix pseudostellariae, 9.09 percent of officinal magnolia bark, 14.55 percent of perilla leaf, 5.45 percent of fried radish seed and 5.46 percent of katsumade galangal seed.
The preparation method comprises the following steps: (1) taking 15g of gypsum, placing the gypsum in an earthenware pot or a stainless steel pot or a pottery pot or a crock or a drug decocting pot or a purple clay pot, adding 400ml of water for soaking, boiling with strong fire, and decocting for 5-120 minutes first; (2) 3g of divaricate saposhnikovia root, 3g of wrinkled gianthyssop herb, 3g of fried gardenia, 2g of liquorice, 10g of heterophylly falsestarwort root, 5g of officinal magnolia bark, 8g of perilla leaf, 3g of fried radish seed and 3g of katsumadai seed are uniformly mixed, placed in a marmite or a stainless steel pot or a pottery pot or a crock or a medicine decocting pot or a purple clay pot, added with water to 400ml, soaked for 20 minutes, boiled over fire with strong fire, then decocted over slow fire for 10-15 minutes, filtered to obtain 200ml of liquid medicine, and taken twice a day. The traditional Chinese medicine is suitable for children patients of 6-10 years old.
Example 5
A traditional Chinese medicine composition for treating infantile fever is prepared from the following raw material medicines in percentage by weight: 5.00 percent of divaricate saposhnikovia root, 5.00 percent of wrinkled gianthyssop herb, 6.67 percent of fried gardenia, 25.00 percent of gypsum, 3.33 percent of liquorice, 20.00 percent of radix pseudostellariae, 10.00 percent of officinal magnolia bark, 15.00 percent of perilla leaf, 5.00 percent of fried radish seed and 5.00 percent of katsumade galangal seed.
The preparation method comprises the following steps: (1) taking 15g of gypsum, placing the gypsum in an earthenware pot or a stainless steel pot or a pottery pot or a crock or a drug decocting pot or a purple clay pot, adding 500ml of water for soaking, boiling with strong fire, and decocting for 5-120 minutes first; (2) 3g of divaricate saposhnikovia root, 3g of wrinkled gianthyssop herb, 4g of fried gardenia, 2g of liquorice, 12g of heterophylly falsestarwort root, 6g of officinal magnolia bark, 9g of perilla leaf, 3g of fried radish seed and 3g of katsumadai seed are uniformly mixed and placed in a marmite or a stainless steel pot or a pottery jar or a crock or a decocting pot or a purple clay pot, water is added to 500ml for soaking for 20 minutes, the mixture is boiled with strong fire on fire, then decocted with slow fire for 10 to 15 minutes, 250ml of liquid medicine is filtered, and the medicine is taken. The traditional Chinese medicine is suitable for children patients of 10-14 years old.
Example 6
A traditional Chinese medicine composition for treating infantile fever is prepared from the following raw material medicines in percentage by weight: 5.97 percent of divaricate saposhnikovia root, 5.97 percent of wrinkled gianthyssop herb, 5.97 percent of fried gardenia, 26.87 percent of gypsum, 4.48 percent of liquorice, 17.91 percent of radix pseudostellariae, 8.95 percent of officinal magnolia bark, 14.92 percent of perilla leaf, 4.48 percent of fried radish seed and 4.48 percent of katsumade galangal seed.
The preparation method comprises the following steps: (1) taking 18g of gypsum, placing in an earthenware pot or a stainless steel pot or a pottery pot or a crock or a drug decocting pot or a purple clay pot, adding 500ml of water for soaking, boiling with strong fire, and decocting for 5-120 minutes first; (2) 4g of divaricate saposhnikovia root, 4g of wrinkled gianthyssop herb, 4g of fried gardenia, 3g of liquorice, 12g of heterophylly falsestarwort root, 6g of officinal magnolia bark, 10g of perilla leaf, 3g of fried radish seed and 3g of katsumadai seed are uniformly mixed and placed in a marmite or a stainless steel pot or a pottery jar or a crock or a medicine decocting pot or a purple clay pot, water is added to 500ml, the mixture is soaked for 20 minutes, the mixture is boiled on fire with strong fire, then decocted on slow fire for 10 to 15 minutes, 250ml of medicine liquid is filtered, and. The traditional Chinese medicine is suitable for 14-18 years old children patients.
Comparative example 1
A traditional Chinese medicine composition for treating infantile fever is prepared from the following raw material medicines in percentage by weight: 6.38 percent of divaricate saposhnikovia root, 6.38 percent of wrinkled gianthyssop herb, 4.26 percent of fried gardenia, 28.72 percent of gypsum, 4.26 percent of liquorice, 24.47 percent of radix pseudostellariae, 8.51 percent of officinal magnolia bark, 10.64 percent of perilla leaf and 6.38 percent of fried radish seed.
The preparation method comprises the following steps: (1) taking 13.5g of gypsum, placing in an earthenware pot or a stainless steel pot or a pottery pot or a crock or a drug decocting pot or a purple clay pot, adding 300ml of water for soaking, boiling with strong fire, and decocting for 5-120 minutes first; (2) 3g of divaricate saposhnikovia root, 3g of wrinkled gianthyssop herb, 2g of fried gardenia, 2g of liquorice, 11.5g of heterophylly falsestarwort root, 4g of officinal magnolia bark, 5g of perilla leaf and 3g of fried radish seed are uniformly mixed and placed in an earthenware pot, a stainless steel pot, a pottery pot, a crock pot, a medicine decocting pot or a purple clay pot, water is added to 300ml, the mixture is soaked for 20 minutes, the mixture is boiled on fire with strong fire, then the mixture is decocted on slow fire for 10 to 15 minutes, and 120ml of medicine liquid is filtered. The traditional Chinese medicine is suitable for children patients of 1-3 years old.
Comparative example 2
A traditional Chinese medicine composition for treating infantile fever is prepared from the following raw material medicines in percentage by weight: 6.38 percent of divaricate saposhnikovia root, 6.38 percent of wrinkled gianthyssop herb, 4.26 percent of fried gardenia, 25.53 percent of gypsum, 4.26 percent of liquorice, 21.28 percent of radix pseudostellariae, 8.51 percent of officinal magnolia bark, 10.64 percent of perilla leaf, 6.38 percent of radish seed and 6.38 percent of katsumade galangal seed.
The preparation method comprises the following steps: (1) taking 12g of gypsum, placing in an earthenware pot or a stainless steel pot or a pottery pot or a crock or a drug decocting pot or a purple clay pot, adding 300ml of water for soaking, boiling with strong fire, and decocting for 5-120 minutes first; (2) 3g of divaricate saposhnikovia root, 3g of wrinkled gianthyssop herb, 2g of fried gardenia, 2g of liquorice, 10g of heterophylly falsestarwort root, 4g of officinal magnolia bark, 5g of perilla leaf, 3g of radish seed and 3g of katsumadai seed are uniformly mixed and placed in an earthenware pot or a stainless steel pot or a pottery pot or a crock or a medicine decocting pot or a purple clay pot, water is added to the mixture to reach 300ml, the mixture is soaked for 20 minutes, the mixture is boiled on fire with strong fire, then decocted on slow fire for 10 to 15 minutes, and 120ml of. The traditional Chinese medicine is suitable for children patients of 1-3 years old.
Comparative example 3
A traditional Chinese medicine composition for treating infantile fever is prepared from the following raw material medicines in percentage by weight: 6.38 percent of divaricate saposhnikovia root, 6.38 percent of wrinkled gianthyssop herb, 4.26 percent of fried gardenia, 28.72 percent of gypsum, 4.26 percent of liquorice, 24.47 percent of radix pseudostellariae, 8.51 percent of officinal magnolia bark, 10.64 percent of perilla leaf and 6.38 percent of radish seed.
The preparation method comprises the following steps: (1) taking 13.5g of gypsum, placing in an earthenware pot or a stainless steel pot or a pottery pot or a crock or a drug decocting pot or a purple clay pot, adding 300ml of water for soaking, boiling with strong fire, and decocting for 5-120 minutes first; (2) 3g of divaricate saposhnikovia root, 3g of wrinkled gianthyssop herb, 2g of fried gardenia, 2g of liquorice, 11.5g of heterophylly falsestarwort root, 4g of officinal magnolia bark, 5g of perilla leaf and 3g of radish seed are uniformly mixed, placed in an earthenware pot, a stainless steel pot, a pottery pot, a crock pot, a medicine decocting pot or a purple clay pot, added with water to 300ml, soaked for 20 minutes, boiled on fire with strong fire, then decocted for 10-15 minutes with slow fire, filtered to obtain 120ml of liquid medicine, and taken twice a day. The traditional Chinese medicine is suitable for children patients of 1-3 years old.
Clinical use effect experiment:
a total of 300 patients with infantile fever with body temperature of 38-40 deg.C and age of 1-3 years were selected and randomly divided into 5 treatment groups and 1 control group, each of which contains 50 patients. The sex and the disease course of each group are statistically processed, and the difference has no significance (P is more than 0.05) and is comparable.
Diagnostic criteria: the infantile fever meets the traditional Chinese medical infantile cold diagnosis standard, and the clinical manifestations of the infantile fever are fever, nasal obstruction, watery nasal discharge or the symptoms of cold such as cough, nausea, vomiting and the like.
The treatment components are treatment 1 group, treatment 2 group, treatment 3 group, treatment 4 group and treatment 5 group, and the traditional Chinese medicine for treating infantile fever obtained according to examples 2 and 4 of the invention and comparative examples 1, 2 and 3 are respectively administered, wherein the administration dosage of the traditional Chinese medicine for treating infantile fever obtained in example 4 for patients in treatment 2 group is reduced by 0.2 times, namely the dosage of all the medicines is reduced by 0.2 times. The patients of the control group take the infantile JINDAN tablet (for dispelling pathogenic wind, eliminating phlegm, clearing heat and detoxicating, and treating common cold fever, excessive phlegm fire, fever and headache, etc.) orally 1 tablet at a time, 3 times a day. 2 weeks is 1 course, and the treatment group and the control group are used for 2 courses.
The curative effect standard is as follows: the method is formulated according to the guiding principle of clinical research of treating infantile exogenous fever (acute upper respiratory infection) by new drugs (traditional Chinese medicines) by the ministry of health of the people's republic of China. Defervescence is the main index. And (3) curing: the body temperature returns to normal level within 24-48h without rising again, and the symptoms disappear; the effect is shown: the body temperature returns to normal level within 24-48h after the medicine is taken, and most of the main symptoms disappear; the method has the following advantages: the body temperature returns to normal level within 24-48h after the medicine is taken, and the main symptoms disappear; and (4) invalidation: not meeting the above criteria.
Wherein the effective rate is the percentage of the number of healed, effective and effective people in the total number of each group.
The treatment conditions of the patients in each treatment group and the patients in the control group are counted, the effective rate is calculated, and the results are shown in table 1.
TABLE 1 therapeutic response rates of the treatment group and the control group
Figure BDA0001960675180000071
From the above experimental results, the treatment effect of the traditional Chinese medicine for treating infantile fever obtained by the raw material ratio in example 2 is better than that of the control group, that is, the effective rate of treating 1 group is higher than that of the control group, which shows that the traditional Chinese medicine obtained according to the formula of the traditional Chinese medicine in example 2 has better effect of treating infantile fever of 1-3 years than that of the common medicines in the market at present, and has low side effect and low recurrence rate.
In addition, compared with the treatment group 2, the treatment group 1 has higher effective rate, which indicates that if the subjects of addition and subtraction of the formula raw materials and the addition and subtraction amount are not selected according to the patients of different ages, the final treatment effect is poorer if the children of different ages are distinguished by controlling the administration amount when the traditional Chinese medicine is taken.
The treatment efficiency of the treatment groups 3, 4 and 5 is lower than that of the treatment group 1, which indicates that the treatment effect of the traditional Chinese medicine for treating infantile fever, which is obtained by lacking alpinia katsumadai and/or not stir-frying radish seed, is not the same as that of the traditional Chinese medicine obtained in the application example 2.

Claims (9)

1. A traditional Chinese medicine composition for treating infantile fever is characterized by being prepared from the following raw material medicines in percentage by weight:
5.00 to 6.38 percent of divaricate saposhnikovia root, 5.00 to 6.38 percent of wrinkled gianthyssop herb, 2.86 to 6.67 percent of fried gardenia, 25.00 to 28.57 percent of gypsum, 2.86 to 4.48 percent of liquorice, 17.91 to 22.86 percent of radix pseudostellariae, 8.51 to 10.00 percent of officinal magnolia bark, 10.64 to 15.00 percent of perilla leaf, 4.48 to 6.38 percent of fried radish seed and 4.48 to 6.38 percent of katsumade galangal seed.
2. The traditional Chinese medicine composition for treating infantile fever as claimed in claim 1, which is prepared from the following raw materials in percentage by weight: 5.71 percent of divaricate saposhnikovia root, 5.71 percent of wrinkled gianthyssop herb, 2.86 percent of fried gardenia, 28.57 percent of gypsum, 2.86 percent of liquorice, 22.86 percent of radix pseudostellariae, 8.57 percent of officinal magnolia bark, 11.44 percent of perilla leaf, 5.71 percent of fried radish seed and 5.71 percent of katsumade galangal seed.
3. The traditional Chinese medicine composition for treating infantile fever as claimed in claim 1, which is prepared from the following raw materials in percentage by weight: 6.38 percent of divaricate saposhnikovia root, 6.38 percent of wrinkled gianthyssop herb, 4.26 percent of fried gardenia, 25.53 percent of gypsum, 4.26 percent of liquorice, 21.28 percent of radix pseudostellariae, 8.51 percent of officinal magnolia bark, 10.64 percent of perilla leaf, 6.38 percent of fried radish seed and 6.38 percent of katsumade galangal seed.
4. The traditional Chinese medicine composition for treating infantile fever as claimed in claim 1, which is prepared from the following raw materials in percentage by weight: 5.66 percent of divaricate saposhnikovia root, 5.66 percent of wrinkled gianthyssop herb, 5.66 percent of fried gardenia, 28.30 percent of gypsum, 3.77 percent of liquorice, 18.87 percent of radix pseudostellariae, 9.44 percent of officinal magnolia bark, 11.32 percent of perilla leaf, 5.66 percent of fried radish seed and 5.66 percent of katsumade galangal seed.
5. The traditional Chinese medicine composition for treating infantile fever as claimed in claim 1, which is prepared from the following raw materials in percentage by weight: 5.45 percent of divaricate saposhnikovia root, 5.45 percent of wrinkled gianthyssop herb, 5.46 percent of fried gardenia, 27.27 percent of gypsum, 3.64 percent of liquorice, 18.18 percent of radix pseudostellariae, 9.09 percent of officinal magnolia bark, 14.55 percent of perilla leaf, 5.45 percent of fried radish seed and 5.46 percent of katsumade galangal seed.
6. The traditional Chinese medicine composition for treating infantile fever as claimed in claim 1, which is prepared from the following raw materials in percentage by weight: 5.00 percent of divaricate saposhnikovia root, 5.00 percent of wrinkled gianthyssop herb, 6.67 percent of fried gardenia, 25.00 percent of gypsum, 3.33 percent of liquorice, 20.00 percent of radix pseudostellariae, 10.00 percent of officinal magnolia bark, 15.00 percent of perilla leaf, 5.00 percent of fried radish seed and 5.00 percent of katsumade galangal seed.
7. The traditional Chinese medicine composition for treating infantile fever as claimed in claim 1, which is prepared from the following raw materials in percentage by weight: 5.97 percent of divaricate saposhnikovia root, 5.97 percent of wrinkled gianthyssop herb, 5.97 percent of fried gardenia, 26.87 percent of gypsum, 4.48 percent of liquorice, 17.91 percent of radix pseudostellariae, 8.95 percent of officinal magnolia bark, 14.92 percent of perilla leaf, 4.48 percent of fried radish seed and 4.48 percent of katsumade galangal seed.
8. The preparation method of the traditional Chinese medicine composition for treating infantile fever as claimed in any one of claims 1-6, comprising the following steps: (1) the raw materials according to any one of claims 1-6, 25.00-28.57% of gypsum is taken, placed in an earthenware pot, a stainless steel pot, a pottery pot, a crock pot, a drug decocting pot or a purple clay pot, soaked in water, boiled with strong fire and decocted for 0.5-1 hour; (2) taking 5.00-6.38% of divaricate saposhnikovia root, 5.00-6.38% of wrinkled gianthyssop herb, 2.86-6.67% of fried gardenia, 2.86-4.48% of liquorice, 17.91-22.86% of radix pseudostellariae, 8.51-10.00% of officinal magnolia bark, 10.64-15.00% of perilla leaf, 4.48-6.38% of fried radish seed and 4.48-6.38% of katsumade galangal seed, uniformly mixing, placing into a marmite or a stainless steel pot or a pottery pot or a crock or a drug decocting pot or a purple clay pot which has been decocted with gypsum, adding water to ensure that the volume-mass ratio of the water to the traditional Chinese medicine raw materials is: 1g, boiling with strong fire, then decocting with slow fire, and filtering to obtain filtrate, namely the traditional Chinese medicine composition for treating infantile fever.
9. The use of the Chinese medicinal composition for treating infantile fever as claimed in any one of claims 1-6 in the preparation of medicament for treating infantile fever.
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小儿发热治验撷要;王进进等;《中华中医药杂志》;20130430(第04期);994-996 *
王进进等.小儿发热治验撷要.《中华中医药杂志》.2013,(第04期), *

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