CN109602666B

CN109602666B - Whitening composition containing lime fruit extract

Info

Publication number: CN109602666B
Application number: CN201910103579.7A
Authority: CN
Inventors: 郑春阳; 王培培; 李磊
Original assignee: Robustnique Corp ltd
Current assignee: Robustnique Corp ltd
Priority date: 2019-02-01
Filing date: 2019-02-01
Publication date: 2022-03-29
Anticipated expiration: 2039-02-01
Also published as: CN109602666A

Abstract

The invention discloses a whitening composition containing a lime fruit extract, which contains functional components of the lime fruit extract, an albizzia julibrissin extract, biological whitening polypeptides, oligopeptide-1, VC derivatives, nicotinamide, phenethyl resorcinol and arbutin. The whitening functional component can reduce melanin synthesis intermediates, reduce the running expression of melanin, reduce the generated melanin, promote the metabolism of epidermal cells, and simultaneously, inhibit glycosylation, oxidation resistance and other ways by inhibiting the melanin synthesis signal transmission, the melanin synthesis substrate competition and the activity of melanin generation key enzymes, more comprehensively inhibit the melanin synthesis and running, effectively reduce chloasma, ultraviolet spots and inflammation deposition spots, and fully whiten and brighten the skin color.

Description

Whitening composition containing lime fruit extract

Technical Field

The invention relates to the technical field of cosmetic formulas, and particularly relates to a whitening composition containing an extract of lime fruits.

Background

Scientifically proves that skin aging and blackening are a complex process, the occurrence of color spots or blackening of the skin is mainly controlled by the content and distribution of melanin in a body, small organ melanosomes in melanocytes are places and sources for melanin generation, and the structural function, the quantity and the activation degree of the melanosomes directly influence the quantity of the melanin generation. Melanocytes cannot be activated autonomously, and keratinocytes and dermal fibroblasts produce secretions after ultraviolet irradiation, thereby activating melanocytes. The main process for melanin synthesis is as follows: ultraviolet rays in sunlight activate keratinocytes to secrete alpha-MSH (melanocyte stimulating hormone), the alpha-MSH is combined with receptors on melanocytes to serve as a signal substance, and the generation of melanin is started, namely, the dopaquinone is gradually generated by taking tyrosine as a precursor through tyrosinase catalysis, and finally the melanin is generated. After melanin synthesis, melanin is transported into epidermal cells through the dendrites, and is discharged out of the body as epidermal cells move up to the stratum corneum and are removed with aging keratoses. In addition, skin complexion is associated with melanin, and also with glycation and excess free radicals in the skin.

However, the existing whitening additives or products in the market have some problems:

1. generally, commercially available whitening products only play a role in inhibiting the activity of the tyrosinase or reducing the number of melanocytes, and few products can achieve whitening in various stages of melanin formation, that is, the whitening pathway is not comprehensive. 2. Partial whitening products are unsafe in raw materials, such as kojic acid, rhododendron alcohol and hydroquinone, mercury chloride in the whitening agent and the like have great cytotoxicity, and have great side effects on skin.

3. The whitening product has unstable performance, for example, VC as a classical whitening component can not only lighten melanin and promote the growth of collagen, but also reduce light damage and resist oxidation. But the whitening and freckle-removing powder is easy to oxidize and deteriorate by visible light during storage and use, so that the whitening and freckle-removing powder does not have the effects of whitening and removing freckles.

4. The absorption of raw materials is problematic, and the stratum corneum of the skin is a brick-slurry anti-leakage structure formed by embedding 4-8 layers of flat anucleate cells filled with keratin in intercellular lipid. Therefore, the whitening preparation cannot pass through the brick-slurry structure and cannot reach the inside of the skin to play a role.

Disclosure of Invention

The invention provides a whitening composition containing an extract of lime fruit aiming at the defects in the prior art.

The purpose of the invention is realized by the following technical scheme:

a whitening composition containing Citrus aurantium fruit extract comprises Citrus aurantium fruit extract, Albizzia julibrissin extract, biological whitening polypeptide, oligopeptide-1, VC derivatives, nicotinamide, phenylethyl resorcinol and arbutin.

The whitening composition comprises the following components in parts by weight: 0.1-50 parts of a lime fruit extract; 0.1-50 parts of albizzia julibrissin durazz extract; 1-20 parts of a VC derivative; 0.1-10 parts of nicotinamide; 0.01-0.5 part of phenethyl resorcinol; 0.01-10 parts of biological whitening polypeptide; 0.01-2 parts of arbutin; 0.01-10 parts of oligopeptide-1.

The biological whitening polypeptide is one or two of nonapeptide and tridecapeptide.

The VC derivative is one or two of ascorbyl tetraisopalmitate, aminopropanol ascorbic acid phosphate and ascorbic acid 2-glucoside.

The whitening composition may be added to a whitening cosmetic.

Further, the cosmetic is in the form of cream, lotion, gel or aqua.

The lime fruit extract is a secondary metabolite obtained by physically squeezing lime fruits treated at low temperature of 0-4 ℃ in a buffer solution system and then filtering the squeezed lime fruits by using a membrane.

Further, the buffer liquid is one of a buffer solution of citric acid and sodium citrate and a buffer solution of disodium hydrogen phosphate and sodium dihydrogen phosphate; the membrane filtration is three-stage filtration: filtering with a filter screen with the aperture of 10-100 meshes, filtering with 200-400 meshes of filter cloth, and filtering with acetate fibers.

The lime fruit belongs to a plant source, and the lime fruit extract has natural mild whitening components: the natural fruit acid, vitamin, polyphenol, flavone, alkaloid, sterol and other substances can well absorb ultraviolet rays, play a role in resisting oxidation and effectively reduce damage caused by oxygen free radicals in skin due to sunshine. The safety and high-efficiency whitening effect of the lime fruit extract is different from the chemical sunscreen agent which is possibly used in the current cosmetics and is capable of causing skin allergy and the physical sunscreen agent with potential dust pollution.

Albizzia julibrissin bark extract has skin whitening effect by anti-glycation effect. Due to factors such as an excessive amount of sugar ingested from food or drink or environmental pollution, excess sugar in the body is released in the blood, and is attached to collagen to undergo condensation, rearrangement and chain extension reactions to produce a highly reactive glycated intermediate, which continues to react with protein to produce an irreversible glycated end product. However, as the metabolism of the skin becomes slow, the glycation products in the body accumulate on the skin, causing problems such as dark yellow skin and color spots.

The VC derivative is one or two of ascorbyl tetraisopalmitate, aminopropanol ascorbic acid phosphate and ascorbic acid 2-glucoside, can protect the stability of easily oxidized groups, and has increased lipophilicity after esterification or glycosylation, better affinity with the skin and easier penetration into the skin; the extracellular phospholipase in vivo can directly hydrolyze VC derivatives and convert into ascorbic acid. Ascorbic acid can inhibit the intermediate step from tyrosine to melanin-reduction of dopaquinone, and can directly reduce the formed melanin, so as to directly whiten the skin.

The biological whitening polypeptide is one or two of tridecapeptide and nonapeptide. The biological whitening polypeptide has small molecular weight, can rapidly penetrate into skin and interfere the combination of alpha-MSH (melanocyte stimulating hormone) and MC1R (melanocortin receptor 1) genes on the surface of a cell membrane through extracellular competitive antagonism, thereby blocking cAMP (cyclic adenosine monophosphate) signal pathways in cells and cell nuclei to reduce MITF (transcription factor), further influencing a main signal pathway in the process of melanin synthesis and directly reducing the synthesis of melanin from a gene level.

Phenethyl resorcinol, arbutin and tyrosine belong to chemical structure similarities, are used as substrates of enzymatic reaction to compete with tyrosine to combine with the active center of tyrosinase, further show the activity of inhibiting the tyrosinase, and directly cut off the synthesis of melanin.

Nicotinamide regulates and inhibits the transport of melanosomes, and reduces melanin secretion.

Oligopeptide-1 is a small molecule active protein, and with the increase of age, the ability of human skin cells to synthesize collagen, hyaluronic acid and other substances gradually decreases, and a series of skin problems gradually begin to appear. Oligopeptide-1 is used as a safe, effective and natural high-tech nursing technology, promotes the synthesis of biomacromolecules such as collagen, elastin, hyaluronic acid and the like, improves the cell metabolism speed, improves the melanin metabolism, and can assist a melanin inhibitor to enhance the whitening effect.

The invention has the beneficial effects that: the whitening functional component can reduce melanin synthesis intermediates, reduce melanin transport, reduce the generated melanin, promote melanin metabolism, and simultaneously match with various ways such as glycosylation inhibition, oxidation resistance and the like under the condition of simultaneously considering raw material stability and skin absorbability, more comprehensively inhibit melanin synthesis and operation, effectively reduce chloasma, ultraviolet spots and inflammation deposition spots, and completely whiten and brighten skin color.

Detailed Description

The invention is further illustrated by the following examples, which are not intended to limit the scope of the invention. The experimental methods without specifying specific conditions in the following examples were selected according to the conventional methods and conditions, or according to the commercial instructions.

In the following examples:

the lime fruit extract is a light brown lime fruit extracting solution obtained by cleaning fresh lime fruits, processing the fresh lime fruits at a low temperature of 0-4 ℃ to preserve the stability of active substances, crushing the fresh lime fruits, physically squeezing the crushed fresh lime fruits in a weak acid buffer solution (the mass ratio of the fresh fruits to the buffer solution is 1:1), and then sequentially carrying out filter screens with the aperture of 10-100 meshes, 200-400-mesh filter cloth and filtration and purification of acetate fibers;

the other raw materials of the skin care product are commercial products.

Example 1 is a whitening lotion formulation; example 2 is a whitening essence formula; example 3 is a whitening emulsion formulation; example 4 is a whitening cream formulation, the specific ingredients are shown in table 1.

The preparation method of the cosmetic containing the whitening composition is a conventional preparation method in the field, and comprises the following steps:

1. respectively weighing the humectant, the thickener and the solvent according to the formula of the embodiment, heating to 80 ℃, and keeping the temperature for 20 minutes to be used as a water phase;

2. respectively weighing an emulsifier, a skin feel improver and an antioxidant according to the formula of the embodiment, and heating until the emulsifier, the skin feel improver and the antioxidant are dissolved to obtain an oil phase;

3. adding the oil phase into the water phase, stirring at high speed and homogenizing;

4. cooling the system to 45 ℃, and sequentially adding the uniformly mixed preservative and whitening agent;

5. cooling the product to room temperature, filtering and discharging.

TABLE 1 various cosmetic formulations containing whitening compositions (parts by weight)

The cosmetics containing the whitening composition prepared in examples 1 to 4 were individually subjected to human body tests by a skin tester. Randomly selecting 50 female volunteers (age range 20-60 years) and using examples 1, 2, 3 and 4 as whitening suit in sequence, wherein the whitening suit is used once in the morning and at night every day, and is stopped after being continuously used for 12 weeks. The VISIA four light sources are used for collecting a whole face image, the whole face image is photographed and stored before use as a blank contrast, and face data are collected every four weeks for 5 times (including contrast). The test items included the skin bright spot area (number), the brown spot area (number) and the ultraviolet spot area (number) three-latitude analysis sample data, and the results are shown in table 2.

Table 2 results of human testing of cosmetics containing whitening composition

	The skin brightness L is improved%	The number of brown spots is reduced%	The number of ultraviolet spots is reduced%
				0 week	0	0.00	0
4 weeks	6.6	42.00	48.7
				8 weeks	7.8	52.90	51.9
For 12 weeks	8.9	54.10	53.2
				For 16 weeks	6.4	43.40	47.5

The results show that the three indexes are obviously and excellently changed after 4 weeks, the change is slow after 8 weeks and 12 weeks, and after the application is stopped for 4 weeks, the rebound phenomena of obvious reduction of skin brightness, obvious increase of color spots and the like do not occur, and the skin does not generate dependence.

It should be understood that the above-described embodiments of the present invention are merely examples for clearly illustrating the present invention, and are not intended to limit the embodiments of the present invention. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. Not all embodiments are exhaustive. All obvious changes and modifications which are obvious to the technical scheme of the invention are covered by the protection scope of the invention.

Claims

1. The whitening composition containing the lime fruit extract is characterized by comprising the following components in parts by weight: 0.1-50 parts of a lime fruit extract; 0.1-50 parts of albizzia julibrissin durazz extract; 1-20 parts of aminopropanol ascorbic acid phosphate; 0.1-10 parts of nicotinamide; 0.01-0.5 part of phenethyl resorcinol; 0.01-10 parts of tridecapeptide; 0.01-2 parts of arbutin; 0.01-10 parts of oligopeptide-1.

2. The whitening composition containing lime fruit extract according to claim 1, wherein the whitening composition can be added to a whitening cosmetic.

3. The whitening composition containing lime fruit extract according to claim 2, wherein the cosmetic is in the form of cream, lotion, gel or aqua, and the cosmetic comprises lotion, essence, lotion, cream, mask, body wash, face toilet, sunscreen, eye cream, foundation or BB cream.

4. A whitening composition according to any of claims 1 to 3, comprising an extract of lime fruit, wherein the extract of lime fruit is a secondary metabolite obtained by physically squeezing lime fruit treated at a low temperature of 0 to 4 ℃ in a buffer system and then filtering the squeezed product with a membrane.

5. The whitening composition of claim 4, wherein the buffer liquid is one of a citric acid and sodium citrate buffer, a disodium hydrogen phosphate and a sodium dihydrogen phosphate buffer.

6. The whitening composition comprising an extract of lime fruit according to claim 4, wherein the membrane filtration is a triple stage filtration: filtering with a filter screen with the aperture of 10-100 meshes, filtering with 200-400 meshes of filter cloth, and filtering with acetate fibers.