CN109575045B - Thienopyrimidine compound, preparation method thereof, medicinal composition and application thereof - Google Patents

Abstract

The present invention relates to a thienopyrimidine compound, its preparation method, pharmaceutical composition and its application. Specifically, it relates to a class of compounds with ALK and/or c-Met selective inhibitory activity, a preparation method thereof, a pharmaceutical composition comprising the compound, and the preparation of these compounds for the prevention or treatment of progressive lymphoma in vivo Use in medicaments for kinase-related diseases, and use in the preparation of medicaments for preventing or treating diseases related to angiogenesis or cancer metastasis, especially in the preparation of medicaments for preventing or treating tumor growth and metastasis use.

Description

Thienopyrimidine compound, its preparation method, pharmaceutical composition and its application

technical field

The present invention relates to the field of medicinal chemistry, in particular, to a class of compounds with ALK and/or c-Met selective inhibitory activity, a preparation method thereof, a pharmaceutical composition comprising the compound, and preparation of these compounds for prevention or treatment Use in medicines for diseases related to progressive lymphoma kinase in vivo, and in the preparation of medicines for the prevention or treatment of diseases related to angiogenesis or cancer metastasis, especially in the preparation of medicines for the prevention or treatment of tumors Use in growth and transfer drugs.

Background technique

Gradient lymphoma kinase (ALK) is a receptor tyrosine kinase that belongs to the insulin receptor superfamily. The protein structure consists of extracellular receptor domain, transmembrane domain and intracellular tyrosine kinase domain from N-terminal to C-terminal. Normal ALK protein is mainly expressed in the central nervous system and peripheral nervous system. The expression level of ALK gene in human body shows a downward trend with the degree of brain development, especially in mature brain tissue. However, the expression of ALK has not been found in other systems, especially the hematopoietic lineage, which proves that its expression and distribution have a certain regionality.

Under normal circumstances, the human ALK gene can encode the 1602 amino acid, 200kDa type I transmembrane protein ALK, but the gene is usually in a dormant state. When fused with other genes, the ALK gene can become a very powerful oncogene. The genes that have been found to be fused with the ALK gene include the nucleophosmin gene (NPM, ALCL with progressive large cell lymphoma), the echinoderms microtubule-associated protein-like 4 gene (EML4, non-small cell lung cancer NSCLC), the protomyocytes Globulin 3 gene (TPM3, inflammatory myofibroblastic tumor IMT) etc. (Nat. Rev. Cancer, 2008, 8, 11-23.; Nat. Rev. Cancer, 2013, 13, 685-700.; Expert Opin. Ther .Pat., 2014.24(4):p.417-42.).

In non-small cell lung cancer, it is mainly fused with EML4 gene, and the incidence of this fusion gene (EML4-ALK) in NSCLC is 4%-7%. With the deepening of molecular biology research on non-small cell lung cancer (NSCLC), personalized therapy based on molecular markers (biomarker) has moved from the laboratory to the clinic, and is being used in the treatment of patients with advanced non-small cell lung cancer. Significant clinical progress has been made. This means that in addition to the traditional histopathological classification of NSCLC, molecular phenotype classification can also be performed based on the different expression levels of different molecular markers in specific patients. NSCLC patients were tested for relevant molecular markers before receiving treatment. In clinic, doctors can carry out targeted treatment according to the molecular phenotype characteristics of the tumor, thereby improving the therapeutic effect. In this context, the research and development of new drugs targeting the driver genes or their encoded proteins that are closely related to the occurrence and development of tumors has become a hot spot in anti-tumor drug research.

At present, the US Food and Drug Administration has approved the small molecule inhibitor CrizotInib (J.Thorac.Oncol., 2010.5(12):p.2044-6.) developed by Pfizer, CrizotInib developed by Novartis Ceritinib (J.Med.Chem., 2013.56(14):p.5675-90.) and Alectinib (Cancer Lett., 2014.351(2):p.215-21.) developed by Chugai PharmaceutICal were launched. However, there are also clinical studies showing that some patients have developed resistance to Crizotinib, and the bioavailability of Crizotinib needs to be improved. Ceritinib can target some patients who have developed resistance or intolerance to Crizotinib. Therefore, their replacement compounds are highly needed in clinical practice to improve drug efficacy and address drug resistance.

SUMMARY OF THE INVENTION

In order to search for new ALK inhibitors, the inventors of the present invention have designed and synthesized a series of novel structures, high safety, and various tyrosine kinases (EGFR, PDGFR, c-Met, etc.), especially Multi-substituted thienopyrimidine (thiophene[3,2-d]pyrimidine) derivatives with high activity to ALK, and the antitumor activity of this new class of derivatives was studied.

The general formula of the compound:

The definitions of the substituents and symbols therein are explained in detail below.

An object of the present invention is to provide a class of compounds with ALK and/or c-Met selective inhibitory activity and pharmaceutically acceptable salts or pharmaceutically acceptable solvates thereof;

Another object of the present invention is to provide a preparation method of the above compound;

Another object of the present invention is to provide a pharmaceutical composition comprising the above compound;

Another object of the present invention is to provide the use of the above-mentioned compound in the preparation of a medicament for the prevention or treatment of diseases associated with progressive lymphoma enzymes in vivo accompanied by abnormal cell proliferation, morphological changes, and hyperkinesia, etc., and in the preparation of Use in medicaments for preventing or treating diseases related to angiogenesis or cancer metastasis, especially in preparing medicaments for preventing or treating tumor growth and metastasis.

Description of drawings

Figure 1 depicts that compound IB-1 significantly inhibited tumor growth in the EML4-ALK(G1202R)-Ba/F3 nude mouse xenograft tumor model. A) Compound IB-1 was administered orally at 60 mg/kg (1 time/day) and 40 mg/kg (2 times/day, bid), respectively, for 10 consecutive days, the tumor growth was significantly inhibited; B) During the administration process, the body weight of the mice in the administration group did not change significantly, indicating that the mice had a good tolerance to the drug, and IB-1 had no obvious side effects.

Figure 2 depicts that Compound IB-1 significantly inhibited tumor growth in a non-small cell lung cancer H3122 cell nude mouse xenograft tumor model. A) Compound IB-1 was administered orally at doses of 30 mg/kg (1 time/day) and 50 mg/kg (1 time/day), respectively, for 18 consecutive days, the tumor growth was significantly inhibited; B) After administration During the course of the drug, the body weight of the mice in the administration group did not change significantly, indicating that the mice had a good tolerance to the drug, and IB-1 had no obvious toxic and side effects.

Detailed description of the invention

The present invention is achieved through the following technical solutions.

In a first aspect, the present invention provides a compound represented by the following general formula I, its stereoisomer, its prodrug, its pharmaceutically acceptable salt or its pharmaceutically acceptable solvate,

Wherein: R' is hydrogen, chlorine or bromine;

R1 is selected from _:

1) C1-C6 alkyl, 2-N,N-dimethylaminoethyl, 2-hydroxyethyl, 2-N,N-diethylaminoethyl, 2-N,N-diisopropyl Aminoethyl, 2-morpholinoethyl, 2-(4-methylpiperazinyl)ethyl, 3-N,N-dimethylaminopropyl, 3-N,N-diethylaminopropyl Base, 3-N,N-diisopropylaminopropyl, 3-morpholinylpropyl, 3-(4-methylpiperazinyl)propyl, C3-C6cycloalkyl, 4-N,N -Dimethylaminocyclohexyl, 4-N,N-diethylaminocyclohexyl, N-methyl-4-piperidinyl, N-ethyl-4-piperidinyl, N-isopropyl-4 -Piperidinyl, 1,3-dimethyl-5-pyrazolyl, 1-methyl-4-pyrazolyl, 3-methyl-5-isoxazolinyl, 1-(N-methyl -4-Piperidinyl)-4-pyrazolyl, 1-(N-tert-butoxycarbonyl-4-piperidinyl)-4-pyrazolyl;

其中Z₁，Z₂，Z₃，Z₄，Z₅各自独立地选自：2)

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from:

(1) hydrogen, fluorine, chlorine, bromine, iodine, nitro, cyano,

(2) C1-C6 alkyl, C1-C6 alkoxy, C1-C6 oxyalkyl, C1-C6 fluoroalkyl, C1-C6 fluoroalkoxy, N-methyl-4-piperidine base,

(3) N,N-dimethylamino, N,N-diethylamino, N,N-diisopropylamino, 2-N,N-dimethylaminoethylamino, 2-morpholino Ethylamino, 2-(4-methylpiperazinyl)ethylamino, 3-N,N-dimethylaminopropylamino, 3-N,N-diethylaminopropylamino, 3-N ,N-diisopropylaminopropylamino, 3-morpholinopropylamino, 3-(4-methylpiperazinyl)propylamino, N-methylpiperidine-4-amino, N-ethyl piperidine-4-amino, N-isopropylpiperidine-4-amino,

(4) 2-N,N-dimethylaminoethoxy, 2-N,N-diethylaminoethoxy, 2-N,N-diisopropylaminoethoxy, 2-(4 -Methylpiperazinyl)ethoxy, 2-(4-acetylpiperazinyl)ethoxy, 2-morpholinylethoxy, 2-thiophenarinylethoxy, 2-piperidinyl Ethoxy, 3-N,N-dimethylaminopropoxy, 3-N,N-diethylaminopropoxy, 3-N,N-diisopropylaminopropoxy, 3-( 4-Methylpiperazinyl)propoxy, 3-(4-Acetylpiperazinyl)propoxy, 3-morpholinopropoxy, 3-thiophenarinylpropoxy, 3-piperidine pyridin-2-ylmethoxy, pyridin-3-ylmethoxy, pyridin-4-ylmethoxy, phenylmethoxy, monohalogen substituted phenylmethoxy, geminal dihalogen Substituted phenylmethoxy, heterodihalogen substituted phenylmethoxy,

(5) piperidinyl, 4-N,N-dimethylaminopiperidinyl, 4-N,N-diethylaminopiperidinyl, 4-N,N-diisopropylaminopiperidinyl, 4-Hydroxypiperidinyl, morpholinyl, 3,5-dimethylmorpholinyl, thiophenaryl, tetrahydropyrrolyl, 3-N,N-dimethylaminotetrahydropyrrolyl, 3-N ,N-Diethylaminotetrahydropyrrolyl, 4-methylpiperazinyl, 4-ethylpiperazinyl, 4-isopropylpiperazinyl, 4-acetylpiperazinyl, 4-tert-butoxy Carbonylpiperazinyl, 4-methanesulfonylpiperazinyl, 4-(2-hydroxyethyl)piperazinyl, 4-(2-cyanoethyl)piperazinyl, 4-(3-hydroxypropyl) Piperazinyl, 4-(2-N,N-Dimethylaminoethyl)piperazinyl, 4-(2-N,N-Diethylaminoethyl)piperazinyl, 4-(3-N ,N-dimethylaminopropyl)piperazinyl, 4-(3-N,N-diethylaminopropyl)piperazinyl, 2-oxo-piperazin-4-yl, imidazolyl, 4 - methylimidazolyl,

(6) 4-(4-Methylpiperazinyl)piperidinyl, 4-(4-ethylpiperazinyl)piperidinyl, 4-(4-isopropylpiperazinyl)piperidinyl, 4 -(4-Acetylpiperazinyl)piperidinyl, 4-(4-tert-butoxycarbonylpiperazinyl)piperidinyl, 4-(4-methanesulfonylpiperazinyl)piperidinyl, 4-( 4-(2-Hydroxyethyl)piperazinyl)piperidinyl, 4-(4-(2-cyanoethyl)piperazinyl)piperidinyl, 4-(4-(3-hydroxypropyl) Piperazinyl) piperidinyl, 4-(4-(2-N,N-dimethylaminoethyl)piperazinyl)piperidinyl, 4-(4-(2-N,N-diethyl) Aminoethyl)piperazinyl)piperidinyl, 4-(4-(3-N,N-dimethylaminopropyl)piperazinyl)piperidinyl, 4-(4-(3-N,N -Diethylaminopropyl)piperazinyl)piperidinyl, 4-(tetrahydropyrrolyl)piperidinyl, 4-(3-N,N-dimethylaminotetrahydropyrrolyl)piperidinyl, 4-(N-methyl-4-piperidinyl)piperazinyl, 4-(N-ethyl-4-piperidinyl)piperazinyl,

(7) Hydroxysulfonyl, aminosulfonyl, methylaminosulfonyl, ethylaminosulfonyl, propylaminosulfonyl, isopropylaminosulfonyl, cyclopropylaminosulfonyl, cyclobutylaminosulfonyl, cyclopentylamino Sulfonyl, piperidin-1-ylsulfonyl, 4-hydroxypiperidin-1-ylsulfonyl, 4-N,N-dimethylaminopiperidin-1-ylsulfonyl, 4-N,N-di Ethylaminopiperidin-1-ylsulfonyl, tetrahydropyrrolyl-1-sulfonyl, 3-N,N-dimethylaminotetrahydropyrrolyl-1-sulfonyl, 3-N,N-diethyl ylaminotetrahydropyrrolyl-1-sulfonyl, 4-methylpiperazin-1-ylsulfonyl, 4-ethylpiperazin-1-ylsulfonyl, 4-acetylpiperazin-1-ylsulfonyl , 4-tert-butoxycarbonylpiperazin-1-ylsulfonyl, 4-(2-hydroxyethyl)piperazin-1-ylsulfonyl, 4-(2-cyanoethyl)piperazin-1-yl Sulfonyl, 4-(2-N,N-dimethylaminoethyl)piperazin-1-ylsulfonyl, 4-(2-N,N-diethylethyl)piperazin-1-ylsulfonyl Acyl, 4-(3-hydroxypropyl)piperazin-1-ylsulfonyl, 4-(3-N,N-dimethylaminopropyl)piperazin-1-ylsulfonyl, 4-(3- N,N-Diethylaminopropyl)piperazin-1-ylsulfonyl, morpholin-1-ylsulfonyl, 3,5-dimethylmorpholin-1-ylsulfonyl, 4-(tetrahydro Pyrrolyl)piperidin-1-ylsulfonyl, 4-(4-methyl-piperazin-1-yl)piperidin-1-ylsulfonyl, 4-(4-ethylpiperazin-1-yl) Piperidin-1-ylsulfonyl, 4-(4-acetyl-1-piperazinyl)piperidin-1-ylsulfonyl, 4-(N-methyl-4-piperidinyl)piperazine-1 -Sulfonyl,

(8) Hydroxycarbonyl, aminocarbonyl, methylaminocarbonyl, ethylaminocarbonyl, propylaminocarbonyl, isopropylaminocarbonyl, cyclopropylaminocarbonyl, cyclobutylaminocarbonyl, cyclopentylaminocarbonyl, piperidinyl-1- Carbonyl, 4-Hydroxypiperidinyl-1-carbonyl, 4-N,N-Dimethylaminopiperidinyl-1-carbonyl, 4-N,N-Diethylaminopiperidinyl-1-carbonyl, 4 -(Tetrahydropyrrolyl)piperidinyl-1-carbonyl, tetrahydropyrrolyl-1-carbonyl, 3-N,N-dimethylaminotetrahydropyrrolyl-1-carbonyl, 3-N,N- Diethylaminotetrahydropyrrolyl-1-carbonyl, 4-methylpiperazin-1-ylcarbonyl, 4-ethylpiperazinyl-1-carbonyl, 4-acetylpiperazinyl-1-carbonyl, 4 -tert-Butoxycarbonylpiperazinyl-1-carbonyl, 4-(2-hydroxyethyl)piperazinyl-1-carbonyl, 4-(2-cyanoethyl)piperazinyl-1-carbonyl, 4- (2-N,N-Dimethylaminoethyl)piperazin-1-ylcarbonyl, 4-(2-N,N-diethylaminoethyl)piperazin-1-ylcarbonyl, 4-(3 -Hydroxypropyl)piperazin-1-ylcarbonyl, 4-(3-N,N-dimethylaminopropyl)piperazin-1-ylcarbonyl, 4-(3-N,N-diethylamino Propyl)piperazin-1-ylcarbonyl, morpholinyl-1-carbonyl, 3,5-dimethylmorpholinyl-1-carbonyl, 4-(4-methyl-piperazin-1-yl)piperyl Perid-1-ylcarbonyl, 4-(4-ethyl-1-piperazinyl)piperidinyl-1-carbonyl, 4-(4-acetyl-piperazin-1-yl)piperidinyl-1- carbonyl, 4-(N-methyl-4-piperidinyl)piperazin-1-ylcarbonyl,

(9) Methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, tert-butoxycarbonyl,

(10) carbamoylamino, methylcarbamoylamino, ethylcarbamoylamino, propylcarbamoylamino, isopropylcarbamoylamino, cyclopropylcarbamoylamino, cyclobutylcarbamoylamino, cyclo Amylcarbamoylamino, piperidinyl-1-carboxamido, 4-hydroxypiperidinyl-1-carboxamido, 4-N,N-dimethylaminopiperidinyl-1-carboxamido, 4-N,N-Diethylaminopiperidinyl-1-carboxamido, tetrahydropyrrolyl-1-carboxamido, 3-N,N-dimethylaminotetrahydropyrrolyl-1-carboxyl Amino, 3-N,N-diethylaminotetrahydropyrrolyl-1-carboxamido, 4-methylpiperazin-1-ylcarboxamido, 4-ethylpiperazin-1-ylcarboxamido , 4-Acetylpiperazin-1-ylcarboxamido, 4-tert-butoxycarbonylpiperazin-1-ylcarboxamido, 4-(2-hydroxyethyl)piperazin-1-ylcarboxamido, 4-(2-cyanoethyl)piperazin-1-ylcarboxamido, 4-(2-N,N-dimethylaminoethyl)piperazin-1-ylcarboxamido, 4-(2 -N,N-Diethylaminoethyl)piperazin-1-ylcarboxamido, 4-(3-hydroxypropyl)piperazin-1-ylcarboxamido, 4-(3-N,N- Dimethylaminopropyl)piperazin-1-ylcarboxamido, 4-(3-N,N-diethylaminopropyl)piperazin-1-ylcarboxamido, morpholin-1-ylmethyl amido, 3,5-dimethylmorpholin-1-ylcarboxamido, 4-(tetrahydropyrrolyl)piperidin-1-ylcarboxamido, 4-(4-methyl-piperazine-1 -yl)piperidin-1-ylcarboxamido, 4-(4-ethylpiperazin-1-yl)piperidin-1-ylcarboxamido, 4-(4-acetyl-piperazin-1yl ) piperidin-1-ylcarboxamido, 4-(N-methyl-4-piperidinyl)piperazin-1-ylcarboxamido; or

(11) Aminoacetamido, 2-dimethylaminoacetamido, N-tert-butoxycarbonylacetamido, N-acetylaminoacetamido, acrylamido, cyclopropionamido, chloroacetamido, piperidinylacetamido , 4-Hydroxypiperidinylacetamido, 4-N,N-Dimethylaminopiperidinylacetamido, 4-N,N-Diethylaminopiperidinylacetamido, Tetrahydropyrrolylacetamido, 3 -N,N-dimethylaminotetrahydropyrrolylacetamido, 3-N,N-diethylaminotetrahydropyrrolylacetamido, 4-methylpiperazinylacetamido, 4-ethylpiperazinyl Acetylamino, 4-acetylpiperazinylacetamido, 4-tert-butoxycarbonylpiperazinylacetamido, 4-(2-hydroxyethyl)piperazinylacetamido, 4-(2-cyanoethyl) Piperazinylacetamido, 4-(2-N,N-dimethylaminoethyl)piperazinylacetamido, 4-(2-N,N-diethylaminoethyl)piperazinylacetamido, 4-(3-Hydroxypropyl)piperazinylacetamido, 4-(3-N,N-dimethylaminopropyl)piperazinylacetamido, 4-(3-N,N-diethylamino Propyl)piperazinylacetamido, morpholinoacetamido, 3,5-dimethylmorpholinoacetamido, 4-(4-methyl-piperazin-1-yl)piperidinylacetamido, 4 -(4-Ethyl-1-piperazinyl)piperidinylacetamido, 4-(4-acetyl-1-piperazinyl)piperidinylacetamido, N-(N-methyl-4-piperidine Peridyl) piperazinylacetamido, 4-(tetrahydropyrrol-1-yl)piperidinylacetamido; 2-methylaminoacetamido, 2-(1-methylethyl)aminoacetamido; N- benzyloxycarbonyl-2methylaminoacetamido;

(12) Z ₂ and Z ₃ or Z ₃ and Z ₄ form an oxygen-containing substituted or unsubstituted five-membered ring or six-membered ring; the substituents can be selected from the same substituents as Z ₁ above,

(13) Z ₂ and Z ₃ or Z ₃ and Z ₄ form a nitrogen-containing substituted or unsubstituted five-membered ring or six-membered ring; the substituents can be selected from the same substituents as Z ₁ above,

其中Z₂，Z₃，Z₄，Z₅与上述2)中定义相同；3)

Wherein Z ₂ , Z ₃ , Z ₄ , Z ₅ are the same as defined in the above 2);

其中Z₁，Z₃，Z₄，Z₅与上述2)中定义相同；4)

Wherein Z ₁ , Z ₃ , Z ₄ , Z ₅ are the same as defined in the above 2);

A is a direct bond or methylene;

X is NH, S or O;

R ₂ is selected from:

1) C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl;

其中A₁，A₂，A₃，A₄，A₅各自独立地选自：2)

wherein A ₁ , A ₂ , A ₃ , A ₄ , A ₅ are each independently selected from:

(1) hydrogen, fluorine, chlorine, bromine, iodine, cyano, trifluoromethyl, trifluoromethoxy, nitro,

(2) Methylthio, ethylthio, isopropylthio, methylsulfinyl, ethylsulfinyl, isopropylsulfinyl, methylsulfonyl, ethylsulfonyl, isopropylsulfonyl, tert-butanesulfonyl , dimethylaminosulfonyl, mesylamino, methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, tert-butoxycarbonyl , methylaminocarbonyl, dimethylaminocarbonyl, ethylaminocarbonyl, propylaminocarbonyl, isopropylaminocarbonyl, cyclopropylaminocarbonyl, cyclobutylaminocarbonyl, cyclopentylaminocarbonyl, dimethylphosphinoyl, diethyl phosphinoyl, diisopropylphosphinoyl,

3)

where Y is an NH, S or O atom,

A ₆ , A ₇ , A ₈ , A ₉ , A ₁₀ , A ₁₁ are each independently selected from:

(1) hydrogen, fluorine, chlorine, bromine, iodine, cyano, trifluoromethyl, trifluoromethoxy, nitro,

(2) Methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, tert-butoxycarbonyl, methylaminocarbonyl, ethylaminocarbonyl, Propylaminocarbonyl, isopropylaminocarbonyl, cyclopropylaminocarbonyl, cyclobutylaminocarbonyl, cyclopentylaminocarbonyl;

4)

where A ₁₂ is selected from:

(1) hydrogen, fluorine, chlorine, bromine, iodine, cyano, trifluoromethyl, trifluoromethoxy, nitro,

(2) Methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, tert-butoxycarbonyl, methylaminocarbonyl, ethylaminocarbonyl, Propylaminocarbonyl, isopropylaminocarbonyl, cyclopropylaminocarbonyl, cyclobutylaminocarbonyl, cyclopentylaminocarbonyl, methylsulfinyl, ethylsulfinyl, isopropylsulfinyl, methylsulfonyl , ethylsulfonyl, isopropylsulfonyl;

Y ₂ , Y ₃ , Y ₄ are selected from the following combinations:

Y ₂ is N, Y ₃ is NA ₁₃ , and Y ₄ is CH or N;

Y ₂ is N, Y ₃ is CA ₁₃ , and Y ₄ is N, O or S;

Y ₂ is O or S, Y ₃ is NA ₁₃ , and Y ₄ is CH;

Y ₂ is O or S, Y ₃ is CA ₁₃ , and Y ₄ is N; and

Y ₂ is C, Y ₃ is NA ₁₃ , and Y ₄ is O or S;

Y ₂ is C, Y ₃ is NA ₁₃ , and Y ₄ is N;

Wherein A ₁₃ is hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl;

5) piperidinyl, 4-N,N-dimethylaminopiperidinyl, 4-N,N-diethylaminopiperidinyl, 4-N,N-diisopropylaminopiperidinyl, 4 -Hydroxypiperidyl, morpholinyl, 3,5-dimethylmorpholinyl, thiophanolinyl, tetrahydropyrrolyl, 3-N,N-dimethylaminotetrahydropyrrolyl, 3-N, N-Diethylaminotetrahydropyrrolyl, 4-methylpiperazinyl, 4-ethylpiperazinyl, 4-isopropylpiperazinyl, 4-acetylpiperazinyl, 4-tert-butoxycarbonyl Piperazinyl, 4-Methanesulfonylpiperazinyl, 4-(2-hydroxyethyl)piperazinyl, 4-(2-cyanoethyl)piperazinyl, 4-(3-hydroxypropyl)piperazinyl Azinyl, 4-(2-N,N-dimethylaminoethyl)piperazinyl, 4-(2-N,N-diethylaminoethyl)piperazinyl, 4-(3-N, N-dimethylaminopropyl)piperazinyl, 4-(3-N,N-diethylaminopropyl)piperazinyl.

In some embodiments, R' is hydrogen.

In some embodiments, wherein R ₁ is selected from:

1) C1-C6 alkyl, 2-N,N-dimethylaminoethyl, 2-hydroxyethyl, 2-N,N-diethylaminoethyl, 2-N,N-diisopropyl Aminoethyl, 2-morpholinoethyl, 2-(4-methylpiperazinyl)ethyl, C3-C6 cycloalkyl, 4-N,N-dimethylaminocyclohexyl, 4-N, N-Diethylaminocyclohexyl, N-methyl-4-piperidinyl, N-ethyl-4-piperidinyl, N-isopropyl-4-piperidinyl, 1,3-dimethyl -5-pyrazolyl, 1-(N-methyl-4-piperidinyl)-4-pyrazolyl;

其中Z₁，Z₂，Z₃，Z₄，Z₅各自独立地选自：2)

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from:

(1) Hydrogen, Fluorine, Chlorine, Bromine, Nitro,

(2) C1-C6 alkyl, C1-C6 alkoxy, C1-C6 oxyalkyl, C1-C6 fluoroalkyl, C1-C6 fluoroalkoxy, N-methyl-4-piperidine base,

(3) N,N-dimethylamino, N,N-diethylamino, N,N-diisopropylamino, 2-N,N-dimethylaminoethylamino, 2-morpholino Ethylamino, 3-morpholinopropylamino, 3-(4-methylpiperazinyl)propylamino, N-methylpiperidine-4-amino, N-ethylpiperidine-4-amino,

(4) 2-N,N-dimethylaminoethoxy, 2-N,N-diethylaminoethoxy, 2-N,N-diisopropylaminoethoxy, 2-(4 -Methylpiperazinyl)ethoxy, 2-(4-acetylpiperazinyl)ethoxy, 2-morpholinylethoxy, 2-thiophenarinylethoxy, 2-piperidinyl Ethoxy, 3-N,N-diisopropylaminopropoxy, 3-(4-acetylpiperazinyl)propoxy, 3-morpholinopropoxy, 3-thiophenidylpropoxy oxy, 3-piperidinylpropoxy, pyridin-2-ylmethoxy, phenylmethoxy, monohalogen substituted phenylmethoxy, geminal dihalogen substituted phenylmethoxy,

(5) piperidinyl, 4-N,N-dimethylaminopiperidinyl, 4-N,N-diethylaminopiperidinyl, 4-N,N-diisopropylaminopiperidinyl, 4-Hydroxypiperidinyl, morpholinyl, 3,5-dimethylmorpholinyl, thiophenaryl, tetrahydropyrrolyl, 3-N,N-dimethylaminotetrahydropyrrolyl, 3-N ,N-Diethylaminotetrahydropyrrolyl, 4-methylpiperazinyl, 4-ethylpiperazinyl, 4-isopropylpiperazinyl, 4-acetylpiperazinyl, 4-(2- Hydroxyethyl)piperazinyl, 4-(3-N,N-diethylaminopropyl)piperazinyl, 2-oxo-piperazin-4-yl, imidazolyl, 4-methylimidazolyl,

(6) 4-(4-Methylpiperazinyl)piperidinyl, 4-(4-ethylpiperazinyl)piperidinyl, 4-(4-isopropylpiperazinyl)piperidinyl, 4 -(4-Acetylpiperazinyl)piperidinyl, 4-(4-tert-butoxycarbonylpiperazinyl)piperidinyl, 4-(4-methanesulfonylpiperazinyl)piperidinyl, 4-( 4-(2-Hydroxyethyl)piperazinyl)piperidinyl, 4-(4-(3-hydroxypropyl)piperazinyl)piperidinyl, 4-(4-(2-N,N-di Methylaminoethyl)piperazinyl)piperidinyl, 4-(4-(2-N,N-diethylaminoethyl)piperazinyl)piperidinyl, 4-(4-(3-N , N-dimethylaminopropyl) piperazinyl) piperidinyl, 4-(3-N,N-dimethylaminotetrahydropyrrolyl) piperidinyl, 4-(N-methyl-4- piperidinyl)piperazinyl, 4-(N-ethyl-4-piperidinyl)piperazinyl,

(7) Hydroxysulfonyl, aminosulfonyl, methylaminosulfonyl, ethylaminosulfonyl, propylaminosulfonyl, isopropylaminosulfonyl, cyclopropylaminosulfonyl, cyclobutylaminosulfonyl, cyclopentylamino Sulfonyl, piperidin-1-ylsulfonyl, 4-hydroxypiperidin-1-ylsulfonyl, 3-N,N-dimethyltetrahydropyrrol-1-ylsulfonyl, 3-N,N-di Ethylaminotetrahydropyrrol-1-ylsulfonyl, 4-methylpiperazin-1-ylsulfonyl, 4-ethylpiperazin-1-ylsulfonyl, 4-acetylpiperazin-1-ylsulfonyl Acyl, 4-tert-butoxycarbonylpiperazinyl-1-sulfonyl, N-(2-hydroxyethyl)piperazinyl-1-sulfonyl, 4-(2-cyanoethyl)piperazinyl-1- sulfonyl, 4-(3-hydroxypropyl)piperazin-1-ylsulfonyl, 4-(3-N,N-dimethylaminopropyl)piperazin-1-ylsulfonyl, 4-( 3-N,N-Diethylaminopropyl)piperazin-1-ylsulfonyl, 4-(4-acetylpiperazin-1-yl)piperidin-1-ylsulfonyl, 4-(N- Methyl-4-piperidinyl)piperazin-1-ylsulfonyl,

(8) Hydroxycarbonyl, aminocarbonyl, methylaminocarbonyl, ethylaminocarbonyl, propylaminocarbonyl, isopropylaminocarbonyl, cyclopropylaminocarbonyl, cyclobutylaminocarbonyl, cyclopentylaminocarbonyl, piperidinyl-1- Carbonyl, 4-hydroxypiperidinyl-1-carbonyl, 4-N,N-dimethylaminopiperidinyl-1-carbonyl, 4-N,N-diethylaminopiperidinyl-1-carbonyl, tetra Hydropyrrolyl-1-carbonyl, 3-N,N-dimethylaminotetrahydropyrrolyl-1-carbonyl, 4-(2-N,N-dimethylaminoethyl)piperazin-1-ylcarbonyl , 4-(2-N,N-diethylaminoethyl)piperazin-1-ylcarbonyl, 4-(3-N,N-diethylaminopropyl)piperazin-1-ylcarbonyl, ? Linen-1-ylcarbonyl, 3,5-dimethylmorpholin-1-ylcarbonyl, 4-(4-methyl-piperazin-1-yl)piperidin-1-ylcarbonyl, 4-(4- Acetyl-1-piperazinyl)piperidin-1-ylcarbonyl, 4-(N-methyl-4-piperidinyl)piperazin-1-ylcarbonyl,

(9) Methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, tert-butoxycarbonyl,

(10) carbamoylamino, methylcarbamoylamino, ethylcarbamoylamino, propylcarbamoylamino, isopropylcarbamoylamino, cyclopropylcarbamoylamino, piperidinyl-1-carboxamido , 4-Hydroxypiperidinyl-1-carboxamido, 4-N,N-dimethylaminopiperidinyl-1-carboxamido, 4-N,N-diethylaminopiperidinyl-1- Formamido, 4-acetylpiperazin-1-ylcarboxamido, 4-(2-hydroxyethyl)piperazin-1-ylcarboxamido, 4-(2-cyanoethyl)piperazine- 1-ylcarboxamido, 4-(2-N,N-dimethylaminoethyl)piperazin-1-ylcarboxamido, 4-(3-N,N-dimethylaminopropyl)piperidine Azin-1-ylcarboxamido, 4-(3-N,N-diethylaminopropyl)piperazin-1-ylcarboxamido, morpholin-1-ylcarboxamido, 4-(4- Acetylpiperazin-1-yl)piperidin-1-ylcarboxamido, 4-(N-methyl-4-piperidinyl)piperazin-1-ylcarboxamido; or

(11) Aminoacetamido, N-tert-butoxycarbonylacetamido, N-acetylaminoacetamido, acrylamido, cyclopropionamido, chloroacetamido, piperidinylacetamido, 4-hydroxypiperidinylacetyl Amino, 4-N,N-Dimethylaminopiperidinylacetamido, 4-N,N-Diethylaminopiperidinylacetamido, 3-N,N-Dimethylaminotetrahydropyrrolylacetamido , N-ethylpiperazinylacetamido, 4-acetylpiperazinylacetamido, 4-tert-butoxycarbonylpiperazinylacetamido, 4-(2-cyanoethyl)piperazinylacetamido, N -(2-N,N-Dimethylaminoethyl)piperazinylacetamido, 4-(2-N,N-diethylaminoethyl)piperazinylacetamido, 4-(3-N, N-dimethylaminopropyl)piperazinylacetamido, 4-(3-N,N-diethylaminopropyl)piperazinylacetamido, 4-(4-methyl-piperazine-1- yl)piperidinylacetamido, 4-(4-ethyl-1-piperazinyl)piperidinylacetamido, 4-(4-acetyl-1-piperazinyl)piperidinylacetamido, N- benzyloxycarbonyl-2methylaminoacetamido;

(12) Z ₂ and Z ₃ or Z ₃ and Z ₄ form an oxygen-containing substituted or unsubstituted five-membered ring or six-membered ring; the substituents can be selected from the same substituents as Z ₁ above,

(13) Z ₂ and Z ₃ or Z ₃ and Z ₄ form a nitrogen-containing substituted or unsubstituted five-membered ring or six-membered ring; the substituents can be selected from the same substituents as Z ₁ above,

其中Z₂，Z₃，Z₄，Z₅与上述2)中定义相同；3)

Wherein Z ₂ , Z ₃ , Z ₄ , Z ₅ are the same as defined in the above 2);

其中Z₁，Z₃，Z₄，Z₅与上述2)中定义相同。4)

Wherein Z ₁ , Z ₃ , Z ₄ , Z ₅ are the same as defined in the above 2).

In some embodiments, R ₁ is selected from:

其中Z₁，Z₂，Z₃，Z₄，Z₅各自独立地选自：1)

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from:

(1) Hydrogen, Fluorine, Chlorine, Bromine, Nitro,

(2) C1-C6 alkyl, C1-C6 alkoxy, C1-C6 fluorine-containing alkyl, C1-C6 fluorine-containing alkoxy,

(3) N,N-dimethylamino, N,N-diethylamino, N,N-diisopropylamino, 2-N,N-dimethylaminoethylamino, 2-morpholino Ethylamino, 3-morpholinopropylamino, 3-(4-methylpiperazinyl)propylamino, N-methylpiperidine-4-amino, N-ethylpiperidine-4-amino,

(4) 2-N,N-dimethylaminoethoxy, 2-N,N-diethylaminoethoxy, 2-N,N-diisopropylaminoethoxy, 2-(4 -Methylpiperazinyl)ethoxy, 2-(4-acetylpiperazinyl)ethoxy, 2-morpholinylethoxy, 2-thiophenarinylethoxy, 2-piperidinyl Ethoxy, 3-N,N-diisopropylaminopropoxy, 3-(4-acetylpiperazinyl)propoxy, 3-morpholinopropoxy, 3-thiophenidylpropoxy oxy, 3-piperidinylpropoxy, pyridin-2-ylmethoxy, phenylmethoxy, monohalogen substituted phenylmethoxy,

(5) piperidinyl, 4-N,N-dimethylaminopiperidinyl, 4-N,N-diethylaminopiperidinyl, 4-N,N-diisopropylaminopiperidinyl, 4-Hydroxypiperidinyl, morpholinyl, 3,5-dimethylmorpholinyl, thiophenaryl, tetrahydropyrrolyl, 3-N,N-dimethylaminotetrahydropyrrolyl, 3-N ,N-Diethylaminotetrahydropyrrolyl, 4-methylpiperazinyl, 4-ethylpiperazinyl, 4-isopropylpiperazinyl, 4-acetylpiperazinyl, 4-(2- Hydroxyethyl)piperazinyl, 4-(3-N,N-diethylaminopropyl)piperazinyl, 2-oxo-piperazin-4-yl, imidazolyl, 4-methylimidazolyl,

(6) 4-(4-Methylpiperazinyl)piperidinyl, 4-(4-ethylpiperazinyl)piperidinyl, 4-(4-isopropylpiperazinyl)piperidinyl, 4 -(4-Acetylpiperazinyl)piperidinyl, 4-(4-tert-butoxycarbonylpiperazinyl)piperidinyl, 4-(4-methanesulfonylpiperazinyl)piperidinyl, 4-( 4-(2-Hydroxyethyl)piperazinyl)piperidinyl, 4-(4-(3-hydroxypropyl)piperazinyl)piperidinyl, 4-(4-(2-N,N-di Methylaminoethyl)piperazinyl)piperidinyl, 4-(4-(3-N,N-dimethylaminopropyl)piperazinyl)piperidinyl, 4-(3-N,N- Dimethylaminotetrahydropyrrolyl)piperidyl, 4-(N-methyl-4-piperidinyl)piperazinyl, 4-(N-ethyl-4-piperidinyl)piperazinyl,

(7) Hydroxysulfonyl, aminosulfonyl, methylaminosulfonyl, ethylaminosulfonyl, propylaminosulfonyl, isopropylaminosulfonyl, cyclopropylaminosulfonyl, cyclobutylaminosulfonyl, cyclopentylamino Sulfonyl, piperidin-1-ylsulfonyl, 4-hydroxypiperidin-1-ylsulfonyl, 3-N,N-dimethylaminotetrahydropyrrolyl-1-sulfonyl, 3-N,N- Diethylaminotetrahydropyrrolyl-1-sulfonyl, 4-methylpiperazin-1-ylsulfonyl, 4-ethylpiperazinyl-1-sulfonyl, 4-acetylpiperazinyl-1- Sulfonyl, 4-tert-butoxycarbonylpiperazinyl-1-sulfonyl, 4-(2-hydroxyethyl)piperazinyl-1-sulfonyl, 4-(2-cyanoethyl)piperazinyl- 1-sulfonyl, 4-(3-N,N-dimethylaminopropyl)piperazinyl-1-sulfonyl, 4-(N-methyl-4-piperidinyl)piperazinyl-1- Sulfonyl,

(8) Hydroxycarbonyl, aminocarbonyl, methylaminocarbonyl, ethylaminocarbonyl, propylaminocarbonyl, isopropylaminocarbonyl, cyclopropylaminocarbonyl, cyclobutylaminocarbonyl, cyclopentylaminocarbonyl, piperidinyl-1- Carbonyl, 4-hydroxypiperidinyl-1-carbonyl, 4-N,N-dimethylaminopiperidinyl-1-carbonyl, 4-N,N-diethylaminopiperidinyl-1-carbonyl, tetra Hydropyrrolyl-1-carbonyl, 3-N,N-dimethylaminotetrahydropyrrolyl-1-carbonyl, 4-(2-N,N-dimethylaminoethyl)piperazinyl-1-carbonyl , 4-(2-N,N-diethylaminoethyl)piperazinyl-1-carbonyl, 4-(3-N,N-diethylaminopropyl)piperazinyl-1-carbonyl, Linoyl-1-carbonyl, 3,5-dimethylmorpholinyl-1-carbonyl, 4-(N-methyl-4-piperidinyl)piperazinyl-1-carbonyl,

(9) Methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, tert-butoxycarbonyl,

(10) carbamoylamino, methylcarbamoylamino, ethylcarbamoylamino, propylcarbamoylamino, isopropylcarbamoylamino, cyclopropylcarbamoylamino, piperidinyl-1-carboxamido , 4-Hydroxypiperidinyl-1-carboxamido, 4-N,N-dimethylaminopiperidinyl-1-carboxamido, 4-N,N-diethylaminopiperidinyl-1- Formamido, 4-acetylpiperazinyl-1-carboxamido, 4-(2-hydroxyethyl)piperazinyl-1-carboxamido, 4-(2-cyanoethyl)piperazinido -1-Carboxamido, 4-(2-N,N-dimethylaminoethyl)piperazinyl-1-carboxamido, 4-(3-N,N-dimethylaminopropyl)piperazine Azinyl-1-carboxamido, 4-(3-N,N-diethylaminopropyl)piperazinyl-1-carboxamido, morpholino-1-carboxamido, 4-(4- Acetyl-1-piperazinyl)piperidinyl-1-carboxamido, 4-(N-methyl-4-piperidinyl)piperazinyl-1-carboxamido; or

(11) Aminoacetamido, N-tert-butoxycarbonylacetamido, N-acetylaminoacetamido, acrylamido, cyclopropionamido, chloroacetamido, piperidinylacetamido, 4-hydroxypiperidinylacetyl Amino, 4-N,N-Dimethylaminopiperidinylacetamido, 4-N,N-Diethylaminopiperidinylacetamido, 3-N,N-Dimethylaminotetrahydropyrrolylacetamido , 4-ethylpiperazinylacetamido, 4-acetylpiperazinylacetamido, 4-tert-butoxycarbonylpiperazinylacetamido, 4-(2-cyanoethyl)piperazinylacetamido, 4 -(2-N,N-Dimethylaminoethyl)piperazinylacetamido, 4-(2-N,N-diethylaminoethyl)piperazinylacetamido, 4-(3-N, N-dimethylaminopropyl)piperazinylacetamido, 4-(3-N,N-diethylaminopropyl)piperazinylacetamido, 4-(4-methyl-piperazine-1- yl)piperidinylacetamido, 4-(4-ethyl-1-piperazinyl)piperidinylacetamido, 4-(4-acetyl-1-piperazinyl)piperidinylacetamido, N- benzyloxycarbonyl-2methylaminoacetamido;

(12) Z ₂ and Z ₃ or Z ₃ and Z ₄ form an oxygen-containing substituted or unsubstituted five-membered ring or six-membered ring; the substituents can be selected from the same substituents as Z ₁ above,

(13) Z ₂ and Z ₃ or Z ₃ and Z ₄ form a nitrogen-containing substituted or unsubstituted five-membered ring or six-membered ring; the substituents can be selected from the same substituents as Z ₁ above,

其中Z₂，Z₃，Z₄，Z₅与上述2)中定义相同；2)

Wherein Z ₂ , Z ₃ , Z ₄ , Z ₅ are the same as defined in the above 2);

其中Z₁，Z₃，Z₄，Z₅与上述2)中定义相同。3)

Wherein Z ₁ , Z ₃ , Z ₄ , Z ₅ are the same as defined in the above 2).

In some embodiments, A is a direct bond.

In some embodiments, A is methylene.

In some embodiments, R ₂ is selected from:

1) C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl;

其中A₁，A₂，A₃，A₄，A₅各自独立地选自：2)

wherein A ₁ , A ₂ , A ₃ , A ₄ , A ₅ are each independently selected from:

(1) hydrogen, fluorine, chlorine, bromine, iodine, nitro,

(2) methylthio, ethylthio, isopropylthio, ethylsulfinyl, isopropylsulfinyl, methylsulfonyl, ethanesulfonyl, isopropylsulfonyl, tert-butanesulfonyl, dimethylaminosulfonyl Acyl, methanesulfonylamino, methoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, cyclobutylaminocarbonyl, methylaminocarbonyl, dimethylaminocarbonyl, isopropylaminocarbonyl, Dimethylphosphinoyl, Diethylphosphinoyl, Diisopropylphosphinoyl,

3)

where Y is an NH, S or O atom,

A ₆ , A ₇ , A ₈ , A ₉ , A ₁₀ , A ₁₁ are each independently selected from:

(1) hydrogen, fluorine, chlorine, bromine, iodine, cyano, trifluoromethyl, trifluoromethoxy, nitro,

(2) Methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, tert-butoxycarbonyl, methylaminocarbonyl, ethylaminocarbonyl, Propylaminocarbonyl, isopropylaminocarbonyl, cyclopentylaminocarbonyl;

4)

where A ₁₂ is selected from:

(1) hydrogen, fluorine, chlorine, bromine, iodine, cyano, trifluoromethyl, trifluoromethoxy, nitro,

(2) Methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, isobutoxycarbonyl, tert-butoxycarbonyl, methylaminocarbonyl, ethylaminocarbonyl, propylaminocarbonyl, isopropyl Aminocarbonyl, cyclobutylaminocarbonyl, methylsulfinyl, methylsulfonyl, ethylsulfonyl, isopropylsulfonyl;

Y ₂ , Y ₃ , Y ₄ are selected from the following combinations:

Y ₂ is N, Y ₃ is NA ₁₃ , and Y ₄ is CH or N;

Y ₂ is O or S, Y ₃ is CA ₁₃ , and Y ₄ is N; and

Y ₂ is C, Y ₃ is NA ₁₃ , and Y ₄ is O or S;

Y ₂ is C, Y ₃ is NA ₁₃ , and Y ₄ is N;

Wherein A ₁₃ is hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl;

5) piperidinyl, 4-N,N-dimethylaminopiperidinyl, 4-N,N-diethylaminopiperidinyl, 4-N,N-diisopropylaminopiperidinyl, 4 -Hydroxypiperidyl, morpholinyl, 3,5-dimethylmorpholinyl, 3-N,N-dimethylaminotetrahydropyrrolyl, 3-N,N-diethylaminotetrahydropyrrolyl , 4-methylpiperazinyl, 4-ethylpiperazinyl, 4-isopropylpiperazinyl, 4-acetylpiperazinyl, 4-(2-N,N-diethylaminoethyl) Piperazinyl, 4-(3-N,N-dimethylaminopropyl)piperazinyl, 4-(3-N,N-diethylaminopropyl)piperazinyl.

In some embodiments, R ₂ is selected from:

其中A₁，A₂，A₃，A₄，A₅各自独立地选自：1)

wherein A ₁ , A ₂ , A ₃ , A ₄ , A ₅ are each independently selected from:

(1) Hydrogen, Fluorine, Chlorine,

(2) methylthio, ethylthio, isopropylthio, ethylsulfinyl, isopropylsulfinyl, methylsulfonyl, ethanesulfonyl, isopropylsulfonyl, tert-butanesulfonyl, dimethylaminosulfonyl Acyl, methanesulfonylamino, methoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, cyclobutylaminocarbonyl, methylaminocarbonyl, dimethylaminocarbonyl, isopropylaminocarbonyl, Dimethylphosphinoyl, Diethylphosphinoyl, Diisopropylphosphinoyl,

2)

where Y is an NH, S or O atom,

A ₆ , A ₇ , A ₈ , A ₉ , A ₁₀ , A ₁₁ are each independently selected from:

(1) hydrogen, fluorine, chlorine, bromine, iodine, cyano, trifluoromethyl, trifluoromethoxy, nitro,

(2) Methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, tert-butoxycarbonyl, methylaminocarbonyl, ethylaminocarbonyl, Propylaminocarbonyl, isopropylaminocarbonyl, cyclopentylaminocarbonyl;

3)

where A ₁₂ is selected from:

(1) hydrogen, fluorine, chlorine, bromine, iodine, cyano, trifluoromethyl, trifluoromethoxy, nitro,

(2) Methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, isobutoxycarbonyl, tert-butoxycarbonyl, methylaminocarbonyl, ethylaminocarbonyl, propylaminocarbonyl, isopropyl Aminocarbonyl, cyclobutylaminocarbonyl, methylsulfinyl, methylsulfonyl, ethylsulfonyl, isopropylsulfonyl;

Y ₂ , Y ₃ , Y ₄ are selected from the following combinations:

Y ₂ is N, Y ₃ is NA ₁₃ , and Y ₄ is CH or N;

Y ₂ is O or S, Y ₃ is CA ₁₃ , and Y ₄ is N; and

Y ₂ is C, Y ₃ is NA ₁₃ , and Y ₄ is O or S;

Y ₂ is C, Y ₃ is NA ₁₃ , and Y ₄ is N;

wherein A ₁₃ is hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl.

In some embodiments, the pharmaceutically acceptable salt is an inorganic acid salt or an organic acid salt, wherein the inorganic acid salt is hydrochloride, hydrobromide, hydroiodide, nitrate, bicarbonate Salts and carbonates, sulfates or phosphates, the organic acid salts being formate, acetate, propionate, benzoate, maleate, fumarate, succinate, tartaric acid salt, citrate, ascorbate, alpha-ketoglutarate, trifluoroacetate, alpha-glycerophosphate, alkylsulfonate or arylsulfonate; preferably, the alkylsulfonate The salt is methanesulfonate or ethylsulfonate; the arylsulfonate is benzenesulfonate or p-toluenesulfonate.

In the second aspect, the present invention provides a compound having the structure of formula V, its stereoisomer, its prodrug, or its pharmaceutically acceptable salt or pharmaceutically acceptable solvate:

Wherein: W is oxo, thio, or hydrogen;

n=0, or 1;

R ₃ , R ₄ , R ₅ are each independently selected from:

(1) hydrogen, fluorine, chlorine, bromine, iodine, nitro, cyano,

(2) C1-C6 alkyl, C1-C6 alkoxy, C1-C6 oxygen-containing alkyl, C1-C6 fluorine-containing alkyl, C1-C6 fluorine-containing alkoxy;

R ₆ is selected from:

(1) Hydrogen, C1-C6 alkyl, acetyl, propionyl, n-butyryl, isobutyryl,

(2) Aminoacetyl, 2-N,N-dimethylacetyl, 2-N,N-diethylacetyl, 2-N,N-diisopropylacetyl, piperidinylacetyl, 4-Hydroxypiperidinylacetyl, 4-N,N-dimethylaminopiperidinylacetyl, 4-N,N-diethylaminopiperidinylacetyl, tetrahydropyrrolylacetyl, 3- N,N-Dimethylaminotetrahydropyrrolylacetyl, 3-N,N-diethylaminotetrahydropyrrolylacetyl, 4-methylpiperazinylacetyl, 4-ethylpiperazinylacetyl base, 4-acetylpiperazinylacetyl, 4-tert-butoxycarbonylpiperazinylacetyl, 4-(2-hydroxyethyl)piperazinylacetyl, 4-(2-cyanoethyl)piperyl Azinylacetyl, 4-(2-N,N-dimethylaminoethyl)piperazinylacetyl, 4-(2-N,N-diethylaminoethyl)piperazinylacetyl, 4 -(3-Hydroxypropyl)piperazinylacetyl, 4-(3-N,N-dimethylaminopropyl)piperazinylacetyl, 4-(3-N,N-diethylaminopropyl yl)piperazinylacetyl, morpholinylacetyl, 3,5-dimethylmorpholinylacetyl, 4-(4-methyl-piperazin-1-yl)piperidinylacetyl, 4- (4-Ethyl-1-piperazinyl)piperidinylacetyl, 4-(4-acetyl-1-piperazinyl)piperidinylacetyl, 4-(N-methyl-4-piperidine base) piperazinyl acetyl;

A, X, R ₂ are the same as defined in the above technical solutions.

In some embodiments, W is oxo.

In some embodiments, n=1.

In some embodiments, n=0.

In some embodiments, R ₃ , R ₄ , R ₅ are each independently selected from:

(1) hydrogen, fluorine, chlorine, bromine, iodine;

(2) C1-C6 alkyl, C1-C6 alkoxy.

In some embodiments, R ₆ is selected from:

(1) Hydrogen, C1-C6 alkyl, acetyl, propionyl,

(2) Aminoacetyl, 2-N,N-dimethylacetyl, 2-N,N-diethylacetyl, 2-N,N-diisopropylacetyl, piperidinylacetyl, 4-Hydroxypiperidinylacetyl, 4-N,N-dimethylaminopiperidinylacetyl, 4-N,N-diethylaminopiperidinylacetyl, tetrahydropyrrolylacetyl, 4- Acetylpiperazinylacetyl, 4-tert-butoxycarbonylpiperazinylacetyl, 4-(2-hydroxyethyl)piperazinylacetyl, 4-(2-cyanoethyl)piperazinylacetyl , 4-(2-N,N-dimethylaminoethyl)piperazinylacetyl, 4-(2-N,N-diethylaminoethyl)piperazinylacetyl, morpholinoacetyl , 3,5-dimethylmorpholinylacetyl, 4-(4-methyl-piperazin-1-yl)piperidinylacetyl, 4-(4-ethyl-1-piperazinyl)piperyl pyridylacetyl.

In some embodiments, the pharmaceutically acceptable salt is an inorganic acid salt or an organic acid salt, wherein the inorganic acid salt is hydrochloride, hydrobromide, hydroiodide, nitrate, bicarbonate Salts and carbonates, sulfates or phosphates, the organic acid salts being formate, acetate, propionate, benzoate, maleate, fumarate, succinate, tartaric acid salt, citrate, ascorbate, alpha-ketoglutarate, trifluoroacetate, alpha-glycerophosphate, alkylsulfonate or arylsulfonate; preferably, the alkylsulfonate The salt is methanesulfonate or ethylsulfonate; the arylsulfonate is benzenesulfonate or p-toluenesulfonate.

In a third aspect, the present invention provides a compound represented by the following general formula IA, its stereoisomer, its prodrug, its pharmaceutically acceptable salt or its pharmaceutically acceptable solvate,

where R1 is selected from:

1) C1-C6 alkyl, 2-N,N-dimethylaminoethyl, 2-hydroxyethyl, 2-N,N-diethylaminoethyl, 2-N,N-diisopropyl Aminoethyl, 2-morpholinoethyl, 2-(4-methylpiperazinyl)ethyl, 3-N,N-dimethylaminopropyl, 3-N,N-diethylaminopropyl Base, 3-N,N-diisopropylaminopropyl, 3-morpholinylpropyl, 3-(4-methylpiperazinyl)propyl, C3-C6cycloalkyl, 4-N,N -Dimethylaminocyclohexyl, 4-N,N-diethylaminocyclohexyl, N-methyl-4-piperidinyl, N-ethyl-4-piperidinyl, N-isopropyl-4 -Piperidinyl, 1,3-dimethyl-5-pyrazolyl, 1-methyl-4-pyrazolyl, 3-methyl-5-isoxazolinyl, 1-(N-methyl -4-Piperidinyl)-4-pyrazolyl, 1-(N-tert-butoxycarbonyl-4-piperidinyl)-4-pyrazolyl;

其中Z₁，Z₂，Z₃，Z₄，Z₅各自独立地选自：2)

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from:

(1) hydrogen, fluorine, chlorine, bromine, iodine, nitro, cyano,

(2) C1-C6 alkyl, C1-C6 alkoxy, C1-C6 oxygen-containing alkyl, C1-C6 fluorine-containing alkyl, C1-C6 fluorine-containing alkoxy,

(3) piperidinyl, N-methyl-4-piperidinyl, 4-N,N-dimethylaminopiperidinyl, 4-N,N-diethylaminopiperidinyl, 4-N, N-diisopropylaminopiperidinyl, 4-hydroxypiperidinyl, 4-(4-methylpiperazinyl)piperidinyl, 4-(4-ethylpiperazinyl)piperidinyl, 4- (4-Isopropylpiperazinyl)piperidinyl, 4-(4-acetylpiperazinyl)piperidinyl, 4-(4-tert-butoxycarbonylpiperazinyl)piperidinyl, 4-(4 -Methylsulfonylpiperazinyl)piperidyl, 4-(4-(2-hydroxyethyl)piperazinyl)piperidyl, 4-(4-(2-cyanoethyl)piperazinyl)piperidyl pyridyl, 4-(4-(3-hydroxypropyl)piperazinyl)piperidinyl, 4-(4-(2-N,N-dimethylaminoethyl)piperazinyl)piperidinyl, 4-(4-(2-N,N-Diethylaminoethyl)piperazinyl)piperidyl, 4-(4-(3-N,N-dimethylaminopropyl)piperazinyl) piperidinyl, 4-(4-(3-N,N-diethylaminopropyl)piperazinyl)piperidinyl, 4-(tetrahydropyrrolyl)piperidinyl, 4-(3-N, N-dimethylaminotetrahydropyrrolyl) piperidinyl,

(4) 4-methylpiperazinyl, 4-ethylpiperazinyl, 4-isopropylpiperazinyl, 4-acetylpiperazinyl, 4-tert-butoxycarbonylpiperazinyl, 4-methanesulfonic acid Acylpiperazinyl, 4-(2-hydroxyethyl)piperazinyl, 4-(2-cyanoethyl)piperazinyl, 4-(3-hydroxypropyl)piperazinyl, 4-(2- N,N-Dimethylaminoethyl)piperazinyl, 4-(2-N,N-diethylaminoethyl)piperazinyl, 4-(3-N,N-dimethylaminopropyl ) piperazinyl, 4-(3-N,N-diethylaminopropyl)piperazinyl, 4-(N-methyl-4-piperidinyl)piperazinyl, 4-(N-ethyl -4-Piperidinyl)piperazinyl,

(5) N,N-dimethylamino, N,N-diethylamino, N,N-diisopropylamino, 2-N,N-dimethylaminoethylamino, 2-morpholino Ethylamino, 2-(4-methylpiperazinyl)ethylamino, 3-N,N-dimethylaminopropylamino, 3-N,N-diethylaminopropylamino, 3-N ,N-diisopropylaminopropylamino, 3-morpholinopropylamino, 3-(4-methylpiperazinyl)propylamino, N-methylpiperidine-4-amino, N-ethyl piperidine-4-amino, N-isopropylpiperidine-4-amino,

(6) 2-N,N-dimethylaminoethoxy, 2-N,N-diethylaminoethoxy, 2-N,N-diisopropylaminoethoxy, 2-(4 -Methylpiperazinyl)ethoxy, 2-(4-acetylpiperazinyl)ethoxy, 2-morpholinylethoxy, 2-thiophenarinylethoxy, 2-piperidinyl Ethoxy, 3-N,N-dimethylaminopropoxy, 3-N,N-diethylaminopropoxy, 3-N,N-diisopropylaminopropoxy, 3-( 4-Methylpiperazinyl)propoxy, 3-(4-Acetylpiperazinyl)propoxy, 3-morpholinopropoxy, 3-thiophenarinylpropoxy, 3-piperidine pyridin-2-ylmethoxy, pyridin-3-ylmethoxy, pyridin-4-ylmethoxy, phenylmethoxy, monohalogen substituted phenylmethoxy, geminal dihalogen Substituted phenylmethoxy, heterodihalogen substituted phenylmethoxy,

(7) Hydroxysulfonyl, aminosulfonyl, methylaminosulfonyl, ethylaminosulfonyl, propylaminosulfonyl, isopropylaminosulfonyl, cyclopropylaminosulfonyl, cyclobutylaminosulfonyl, cyclopentylamino Sulfonyl, piperidin-1-ylsulfonyl, 4-hydroxypiperidin-1-ylsulfonyl, 4-N,N-dimethylaminopiperidin-1-ylsulfonyl, 4-N,N-di Ethylaminopiperidin-1-ylsulfonyl, tetrahydropyrrolyl-1-sulfonyl, 3-N,N-dimethylaminotetrahydropyrrolyl-1-sulfonyl, 3-N,N-diethyl ylaminotetrahydropyrrolyl-1-sulfonyl, 4-methylpiperazin-1-ylsulfonyl, 4-ethylpiperazinyl-1-sulfonyl, 4-acetylpiperazinyl-1-sulfonyl , 4-tert-butoxycarbonylpiperazinyl-1-sulfonyl, 4-(2-hydroxyethyl)piperazinyl-1-sulfonyl, 4-(2-cyanoethyl)piperazinyl-1- Sulfonyl, 4-(2-N,N-dimethylaminoethyl)piperazinyl-1-sulfonyl, 4-(2-N,N-diethylethyl)piperazinyl-1-sulfonyl Acyl, 4-(3-hydroxypropyl)piperazinyl-1-sulfonyl, 4-(3-N,N-dimethylaminopropyl)piperazinyl-1-sulfonyl, 4-(3- N,N-Diethylaminopropyl)piperazinyl-1-sulfonyl, morpholinyl-1-sulfonyl, 3,5-dimethylmorpholinyl-1-sulfonyl, 4-(4- Methyl-piperazin-1-yl)piperidin-1-ylsulfonyl, 4-(4-ethyl-1-piperazinyl)piperidin-1-ylsulfonyl, 4-(4-acetyl- 1-Piperazinyl)piperidin-1-ylsulfonyl, 4-(N-methyl-4-piperidinyl)piperazinyl-1-sulfonyl,

(8) Hydroxycarbonyl, aminocarbonyl, methylaminocarbonyl, ethylaminocarbonyl, propylaminocarbonyl, isopropylaminocarbonyl, cyclopropylaminocarbonyl, cyclobutylaminocarbonyl, cyclopentylaminocarbonyl, piperidinyl-1- Carbonyl, 4-hydroxypiperidinyl-1-carbonyl, 4-N,N-dimethylaminopiperidinyl-1-carbonyl, 4-N,N-diethylaminopiperidinyl-1-carbonyl, tetra Hydropyrrolyl-1-carbonyl, 3-N,N-dimethylaminotetrahydropyrrolyl-1-carbonyl, 3-N,N-diethylaminotetrahydropyrrolyl-1-carbonyl, 4-methyl Piperazin-1-ylcarbonyl, 4-ethylpiperazinyl-1-carbonyl, 4-acetylpiperazinyl-1-carbonyl, 4-tert-butoxycarbonylpiperazinyl-1-carbonyl, 4-(2 -Hydroxyethyl)piperazinyl-1-carbonyl, 4-(2-cyanoethyl)piperazinyl-1-carbonyl, 4-(2-N,N-dimethylaminoethyl)piperazinyl -1-carbonyl, 4-(2-N,N-diethylaminoethyl)piperazinyl-1-carbonyl, 4-(3-hydroxypropyl)piperazinyl-1-carbonyl, 4-(3 -N,N-Dimethylaminopropyl)piperazinyl-1-carbonyl, 4-(3-N,N-diethylaminopropyl)piperazinyl-1-carbonyl, morpholinyl-1- Carbonyl, 3,5-dimethylmorpholinyl-1-carbonyl, 4-(4-methyl-piperazin-1-yl)piperidin-1-ylcarbonyl, 4-(4-ethyl-1- Piperazinyl)piperidinyl-1-carbonyl, 4-(4-acetyl-1-piperazinyl)piperidinyl-1-carbonyl, 4-(N-methyl-4-piperidinyl)piperazine yl-1-carbonyl, methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, tert-butoxycarbonyl,

(9) carbamoylamino, methylcarbamoylamino, ethylcarbamoylamino, propylcarbamoylamino, isopropylcarbamoylamino, cyclopropylcarbamoylamino, cyclobutylcarbamoylamino, cyclo Amylcarbamoylamino, piperidinyl-1-carboxamido, 4-hydroxypiperidinyl-1-carboxamido, 4-N,N-dimethylaminopiperidinyl-1-carboxamido, 4-N,N-Diethylaminopiperidinyl-1-carboxamido, tetrahydropyrrolyl-1-carboxamido, 3-N,N-dimethylaminotetrahydropyrrolyl-1-carboxyl Amino, 3-N,N-diethylaminotetrahydropyrrolyl-1-carboxamido, 4-methylpiperazinyl-1-carboxamido, 4-ethylpiperazinyl-1-carboxamido , 4-Acetyl piperazinyl-1-carboxamido, 4-tert-butoxycarbonyl piperazinyl-1-carboxamido, 4-(2-hydroxyethyl) piperazinyl-1-carboxamido, 4-(2-cyanoethyl)piperazinyl-1-carboxamido, 4-(2-N,N-dimethylaminoethyl)piperazinyl-1-carboxamido, 4-(2 -N,N-Diethylaminoethyl)piperazinyl-1-carboxamido, 4-(3-hydroxypropyl)piperazinyl-1-carboxamido, 4-(3-N,N- Dimethylaminopropyl)piperazinyl-1-carboxamido, 4-(3-N,N-diethylaminopropyl)piperazinyl-1-carboxamido, morpholino-1-methyl amido, 3,5-dimethylmorpholino-1-carboxamido, 4-(4-methyl-piperazin-1-yl)piperidinyl-1-carboxamido, 4-(4- Ethyl-1-piperazinyl)piperidinyl-1-carboxamido, 4-(4-acetyl-1-piperazinyl)piperidinyl-1-carboxamido, 4-(N-methyl -4-Piperidinyl)piperazinyl-1-carboxamido; or

(10) Z ₂ and Z ₃ or Z ₃ and Z ₄ form a nitrogen- or oxygen-containing substituted or unsubstituted five-membered ring or six-membered ring, and the substituents can be selected from the same substituents as Z ₁ ;

其中A₁，A₂，A₃，A₄，A₅各自独立地选自：R2 is selected from:

wherein A ₁ , A ₂ , A ₃ , A ₄ , A ₅ are each independently selected from:

(1) hydrogen, fluorine, chlorine, bromine, iodine, cyano, trifluoromethyl, trifluoromethoxy, nitro,

(2) methylthio, ethylthio, isopropylthio, methylsulfinyl, ethylsulfinyl, isopropylsulfinyl, methylsulfonyl, ethylsulfonyl, isopropylsulfonyl, methanesulfonylamino , methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, tert-butoxycarbonyl, methylaminocarbonyl, ethylaminocarbonyl, propylamino Carbonyl, isopropylaminocarbonyl, cyclopropylaminocarbonyl, cyclobutylaminocarbonyl, cyclopentylaminocarbonyl, dimethylphosphinoyl, diethylphosphinoyl, diisopropylphosphinoyl.

In some embodiments, R1 is selected from:

其中Z₁，Z₂，Z₃，Z₄，Z₅各自独立地选自：

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from:

(1) Hydrogen,

(2) C1-C6 alkyl,

(3) C1-C6 alkoxy,

(4) piperidinyl, N-methyl-4-piperidinyl, 4-N,N-dimethylaminopiperidinyl, 4-N,N-diethylaminopiperidinyl, 4-N, N-diisopropylaminopiperidinyl, 4-hydroxypiperidinyl,

(5) 4-(4-Methylpiperazinyl)piperidinyl, 4-(4-ethylpiperazinyl)piperidinyl, 4-(4-isopropylpiperazinyl)piperidinyl, 4 -(4-Acetylpiperazinyl)piperidinyl, 4-(4-tert-butoxycarbonylpiperazinyl)piperidinyl, 4-(4-methanesulfonylpiperazinyl)piperidinyl, 4-( 4-(2-Hydroxyethyl)piperazinyl)piperidinyl, 4-(4-(2-cyanoethyl)piperazinyl)piperidinyl, 4-(4-(3-hydroxypropyl) Piperazinyl) piperidinyl, 4-(4-(2-N,N-dimethylaminoethyl)piperazinyl)piperidinyl, 4-(4-(2-N,N-diethyl) Aminoethyl)piperazinyl)piperidinyl, 4-(4-(3-N,N-dimethylaminopropyl)piperazinyl)piperidinyl, 4-(4-(3-N,N -Diethylaminopropyl)piperazinyl)piperidinyl, 4-(tetrahydropyrrolyl)piperidinyl, 4-(3-N,N-dimethylaminotetrahydropyrrolyl)piperidinyl,

(6) 4-methylpiperazinyl, 4-ethylpiperazinyl, 4-isopropylpiperazinyl, 4-acetylpiperazinyl, 4-tert-butoxycarbonylpiperazinyl, 4-methanesulfonic acid Acylpiperazinyl, 4-(2-hydroxyethyl)piperazinyl, 4-(2-cyanoethyl)piperazinyl, 4-(3-hydroxypropyl)piperazinyl, 4-(2- N,N-Dimethylaminoethyl)piperazinyl, 4-(2-N,N-diethylaminoethyl)piperazinyl, 4-(3-N,N-dimethylaminopropyl ) piperazinyl, 4-(3-N,N-diethylaminopropyl)piperazinyl, 4-(N-methyl-4-piperidinyl)piperazinyl, 4-(N-ethyl -4-Piperidinyl)piperazinyl, or

(7) Z ₂ and Z ₃ or Z ₃ and Z ₄ form a nitrogen- or oxygen-containing substituted or unsubstituted five-membered or six-membered ring, and the substituents can be selected from the same substituents as those of Z ₁ .

In some embodiments, R1 is selected from:

其中Z₁，Z₂，Z₃，Z₄，Z₅各自独立地选自：

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from:

(1) Hydrogen,

(2) methyl,

(3) Methoxy,

(4) N-methyl-4-piperidinyl,

(5) 4-methylpiperazinyl,

(6) 4-(4-methylpiperazinyl) piperidinyl,

(7) 4-(tetrahydropyrrol-1-yl)piperidinyl, or

(8) Z ₂ and Z ₃ or Z ₃ and Z ₄ form

In some embodiments, R1 is selected from:

其中Z₁和Z₅二者之一为氢，另一为甲氧基；1)

Wherein one of Z ₁ and Z ₅ is hydrogen, and the other is methoxy;

One of Z ₂ and Z ₄ is hydrogen, and the other is methyl;

Z ₃ is selected from: N-methyl-4-piperidinyl, 4-methylpiperazinyl, 4-(4-methylpiperazinyl)piperidinyl, 4-(tetrahydropyrrol-1-yl) piperidinyl, or

Z ₂ and Z ₃ or Z ₃ and Z ₄ form

其中A₁，A₂，A₃，A₄，A₅各自独立地选自：(1)氢，(2)甲磺酰基。In some embodiments, R2 is selected from:

wherein A ₁ , A ₂ , A ₃ , A ₄ , A ₅ are each independently selected from: (1) hydrogen, (2) methanesulfonyl.

其中A₁和A₅二者之一为氢，另一为甲磺酰基；A₂，A₃，A₄都为氢。In some embodiments, R2 is selected from:

One of A ₁ and A ₅ is hydrogen, and the other is methanesulfonyl; A ₂ , A ₃ and A ₄ are all hydrogen.

In a fourth aspect, the present invention provides a compound represented by the following general formula IB, its stereoisomer, its prodrug, its pharmaceutically acceptable salt or its pharmaceutically acceptable solvate,

where R1 is selected from:

1) C1-C6 alkyl, 2-N,N-dimethylaminoethyl, 2-hydroxyethyl, 2-N,N-diethylaminoethyl, 2-N,N-diisopropyl Aminoethyl, 2-morpholinoethyl, 2-(4-methylpiperazinyl)ethyl, 3-N,N-dimethylaminopropyl, 3-N,N-diethylaminopropyl Base, 3-N,N-diisopropylaminopropyl, 3-morpholinylpropyl, 3-(4-methylpiperazinyl)propyl, C3-C6cycloalkyl, 4-N,N -Dimethylaminocyclohexyl, 4-N,N-diethylaminocyclohexyl, N-methyl-4-piperidinyl, N-ethyl-4-piperidinyl, N-isopropyl-4 -Piperidinyl, 1,3-dimethyl-5-pyrazolyl, 1-methyl-4-pyrazolyl, 3-methyl-5-isoxazolinyl, 1-(N-methyl -4-Piperidinyl)-4-pyrazolyl, 1-(N-tert-butoxycarbonyl-4-piperidinyl)-4-pyrazolyl;

其中Z₁，Z₂，Z₃，Z₄，Z₅各自独立地选自：2)

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from:

(1) hydrogen, fluorine, chlorine, bromine, iodine, nitro, cyano,

(2) C1-C6 alkyl, C1-C6 alkoxy, C1-C6 oxygen-containing alkyl, C1-C6 fluorine-containing alkyl, C1-C6 fluorine-containing alkoxy,

(3) piperidinyl, N-methyl-4-piperidinyl, 4-N,N-dimethylaminopiperidinyl, 4-N,N-diethylaminopiperidinyl, 4-N, N-diisopropylaminopiperidinyl, 4-hydroxypiperidinyl, 4-(4-methylpiperazinyl)piperidinyl, 4-(4-ethylpiperazinyl)piperidinyl, 4- (4-Isopropylpiperazinyl)piperidinyl, 4-(4-acetylpiperazinyl)piperidinyl, 4-(4-tert-butoxycarbonylpiperazinyl)piperidinyl, 4-(4 -Methylsulfonylpiperazinyl)piperidyl, 4-(4-(2-hydroxyethyl)piperazinyl)piperidyl, 4-(4-(2-cyanoethyl)piperazinyl)piperidyl pyridyl, 4-(4-(3-hydroxypropyl)piperazinyl)piperidinyl, 4-(4-(2-N,N-dimethylaminoethyl)piperazinyl)piperidinyl, 4-(4-(2-N,N-Diethylaminoethyl)piperazinyl)piperidyl, 4-(4-(3-N,N-dimethylaminopropyl)piperazinyl) piperidinyl, 4-(4-(3-N,N-diethylaminopropyl)piperazinyl)piperidinyl, 4-(tetrahydropyrrolyl)piperidinyl, 4-(3-N, N-dimethylaminotetrahydropyrrolyl) piperidinyl,

(4) 4-methylpiperazinyl, 4-ethylpiperazinyl, 4-isopropylpiperazinyl, 4-acetylpiperazinyl, 4-tert-butoxycarbonylpiperazinyl, 4-methanesulfonic acid Acylpiperazinyl, 4-(2-hydroxyethyl)piperazinyl, 4-(2-cyanoethyl)piperazinyl, 4-(3-hydroxypropyl)piperazinyl, 4-(2- N,N-Dimethylaminoethyl)piperazinyl, 4-(2-N,N-diethylaminoethyl)piperazinyl, 4-(3-N,N-dimethylaminopropyl ) piperazinyl, 4-(3-N,N-diethylaminopropyl)piperazinyl, 4-(N-methyl-4-piperidinyl)piperazinyl, 4-(N-ethyl -4-Piperidinyl)piperazinyl, 2-oxo-piperazin-4-yl,

(5) morpholinyl, 3,5-dimethylmorpholinyl, thiophanolinyl,

(6) Hydroxysulfonyl, aminosulfonyl, methylaminosulfonyl, ethylaminosulfonyl, propylaminosulfonyl, isopropylaminosulfonyl, cyclopropylaminosulfonyl, cyclopentylaminosulfonyl, piperidine-1 -ylsulfonyl, 4-hydroxypiperidin-1-ylsulfonyl, 4-N,N-dimethylaminopiperidin-1-ylsulfonyl, 4-N,N-diethylaminopiperidin-1 -ylsulfonyl, tetrahydropyrrolyl-1-sulfonyl, 3-N,N-diethylaminotetrahydropyrrolyl-1-sulfonyl, 4-methylpiperazin-1-ylsulfonyl, 4- Ethylpiperazinyl-1-sulfonyl, 4-acetylpiperazinyl-1-sulfonyl, 4-(2-hydroxyethyl)piperazinyl-1-sulfonyl, 4-(2-cyanoethyl) yl)piperazinyl-1-sulfonyl, 4-(2-N,N-dimethylaminoethyl)piperazinyl-1-sulfonyl, 4-(2-N,N-diethylethyl ) piperazinyl-1-sulfonyl, 4-(3-hydroxypropyl)piperazinyl-1-sulfonyl, 4-(3-N,N-diethylaminopropyl)piperazinyl-1- Sulfonyl, morpholinyl-1-sulfonyl, 3,5-dimethylmorpholinyl-1-sulfonyl, 4-(4-methyl-piperazin-1-yl)piperidin-1-ylsulfonyl Acyl, 4-(4-ethyl-1-piperazinyl)piperidin-1-ylsulfonyl, 4-(N-methyl-4-piperidinyl)piperazinyl-1-sulfonyl,

(7) 4-(4-Methyl-piperazin-1-yl)piperidin-1-ylcarbonyl, 4-methylpiperazin-1-ylcarbonyl, 4-ethylpiperazinyl-1-carbonyl, Cyclobutylaminocarbonyl, cyclopentylaminocarbonyl, piperidinyl-1-carbonyl, 4-hydroxypiperidinyl-1-carbonyl, 4-N,N-dimethylaminopiperidinyl-1-carbonyl, 4 -N,N-Diethylaminopiperidinyl-1-carbonyl, tetrahydropyrrolyl-1-carbonyl, 3-N,N-dimethylaminotetrahydropyrrolyl-1-carbonyl, 3-N,N -Dimethylaminotetrahydropyrrolyl-1-carbonyl, 3-N,N-diethylaminotetrahydropyrrolyl-1-carbonyl, 4-(2-hydroxyethyl)piperazine 3-N,N- Diethylaminotetrahydropyrrolyl-1-carbonyl, yl-1-carbonyl, 4-(3-hydroxypropyl)piperazinyl-1-carbonyl, 4-(3-N,N-dimethylaminopropyl yl)piperazinyl-1-carbonyl, 4-(3-N,N-diethylaminopropyl)piperazinyl-1-carbonyl, morpholinyl-1-carbonyl, hydroxycarbonyl, aminocarbonyl, methylamino Carbonyl, ethylaminocarbonyl, propylaminocarbonyl, isopropylaminocarbonyl, cyclopropylaminocarbonyl, 3,5-dimethylmorpholinyl-1-carbonyl, methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl , isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, tert-butoxycarbonyl,

(8) pyridin-2-ylmethoxy, pyridin-3-ylmethoxy, pyridin-4-ylmethoxy, phenylmethoxy, monohalo-substituted phenylmethoxy, or

(9) Z ₂ and Z ₃ or Z ₃ and Z ₄ form a nitrogen- or oxygen-containing substituted or unsubstituted five-membered ring or six-membered ring, and the substituents can be selected from the same substituents as Z ₁ ;

其中Z₂，Z₃，Z₄，Z₅与上述2)中定义相同；4)

其中Z₁，Z₃，Z₄，Z₅与上述2)中定义相同；3)

Wherein Z ₂ , Z ₃ , Z ₄ , Z ₅ are the same as defined in the above 2); 4)

Wherein Z ₁ , Z ₃ , Z ₄ , Z ₅ are the same as defined in the above 2);

其中A₁，A₂，A₃，A₄，A₅各自独立地选自：R2 is selected from:

wherein A ₁ , A ₂ , A ₃ , A ₄ , A ₅ are each independently selected from:

(1) hydrogen, fluorine, chlorine, bromine, iodine, cyano, trifluoromethyl, trifluoromethoxy, nitro,

(2) methylthio, ethylthio, isopropylthio, methylsulfinyl, ethylsulfinyl, isopropylsulfinyl, methylsulfonyl, ethylsulfonyl, isopropylsulfonyl, methanesulfonylamino , methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, tert-butoxycarbonyl, methylaminocarbonyl, ethylaminocarbonyl, propylamino Carbonyl, isopropylaminocarbonyl, cyclopropylaminocarbonyl, cyclobutylaminocarbonyl, cyclopentylaminocarbonyl, dimethylphosphinoyl, diethylphosphinoyl, diisopropylphosphinoyl.

In some embodiments, R1 is selected from:

其中Z₁，Z₂，Z₃，Z₄，Z₅各自独立地选自：1)

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from:

(1) Hydrogen,

(2) C1-C6 alkyl,

(3) C1-C6 alkoxy,

(4) N-methyl-4-piperidinyl, 4-hydroxypiperidinyl, 4-(4-methylpiperazinyl)piperidinyl, 4-(tetrahydropyrrolyl)piperidinyl, piperidine base, 4-N,N-dimethylaminopiperidinyl, 4-N,N-diethylaminopiperidinyl, 4-N,N-diisopropylaminopiperidinyl,

(5) 4-methylpiperazinyl, 4-ethylpiperazinyl, 4-isopropylpiperazinyl, 4-acetylpiperazinyl, 4-tert-butoxycarbonylpiperazinyl, 4-methanesulfonic acid Acylpiperazinyl, 4-(2-hydroxyethyl)piperazinyl, 4-(2-cyanoethyl)piperazinyl, 4-(3-hydroxypropyl)piperazinyl, 4-(2- N,N-Dimethylaminoethyl)piperazinyl, 4-(2-N,N-diethylaminoethyl)piperazinyl, 4-(3-N,N-dimethylaminopropyl ) piperazinyl, 4-(3-N,N-diethylaminopropyl)piperazinyl, 2-oxo-piperazin-4-yl

(6) morpholinyl, 3,5-dimethylmorpholinyl,

(7) 4-Hydroxypiperidin-1-ylsulfonyl, 4-methylpiperazin-1-ylsulfonyl, hydroxysulfonyl, aminosulfonyl, methylaminosulfonyl, propylaminosulfonyl, isopropylaminosulfonyl Acyl, cyclopropylaminosulfonyl, cyclobutylaminosulfonyl, piperidin-1-ylsulfonyl, 4-hydroxypiperidin-1-ylsulfonyl, 4-N,N-dimethylaminopiperidine- 1-ylsulfonyl, 4-N,N-diethylaminopiperidin-1-ylsulfonyl, tetrahydropyrrolyl-1-sulfonyl, 3-N,N-dimethylaminotetrahydropyrrolyl- 1-sulfonyl, 3-N,N-diethylaminotetrahydropyrrolyl-1-sulfonyl, 4-ethylpiperazinyl-1-sulfonyl,

(8) 4-(4-Methyl-piperazin-1-yl)piperidin-1-ylcarbonyl, 4-methylpiperazin-1-ylcarbonyl, cyclobutylaminocarbonyl, cyclopentylaminocarbonyl, Piperidinyl-1-carbonyl, 4-hydroxypiperidinyl-1-carbonyl, 4-N,N-dimethylaminopiperidinyl-1-carbonyl, 4-N,N-diethylaminopiperidinyl -1-Carbonyl, tetrahydropyrrolyl-1-carbonyl, 3-N,N-dimethylaminotetrahydropyrrolyl-1-carbonyl, 3-N,N-diethylaminotetrahydropyrrolyl-1- Carbonyl, 4-(3-hydroxypropyl)piperazinyl-1-carbonyl, 4-(3-N,N-dimethylaminopropyl)piperazinyl-1-carbonyl, 4-(3-N, N-diethylaminopropyl) piperazinyl-1-carbonyl, morpholinyl-1-carbonyl,

(9) pyridin-2-ylmethoxy, pyridin-2-ylmethoxy, pyridin-3-ylmethoxy, pyridin-4-ylmethoxy, phenylmethoxy, monohalogen substituted phenyl methoxy, or

(10) Z ₂ and Z ₃ or Z ₃ and Z ₄ form a nitrogen- or oxygen-containing substituted or unsubstituted five-membered ring or six-membered ring, and the substituents can be selected from the same substituents as Z ₁ ;

其中Z₂，Z₃，Z₄，Z₅与上述2)中定义相同；2)

Wherein Z ₂ , Z ₃ , Z ₄ , Z ₅ are the same as defined in the above 2);

其中Z₁，Z₃，Z₄，Z₅与上述2)中定义相同。3)

Wherein Z ₁ , Z ₃ , Z ₄ , Z ₅ are the same as defined in the above 2).

In some embodiments, R1 is selected from:

其中Z₁，Z₂，Z₃，Z₄，Z₅各自独立地选自：1)

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from:

(1) Hydrogen,

(2) methyl,

(3) Methoxy, ethoxy, isopropoxy,

(4) N-methyl-4-piperidinyl, 4-hydroxypiperidinyl, 4-(4-methylpiperazinyl)piperidinyl, 4-(tetrahydropyrrol-1-yl)piperidinyl , 4-Dimethylamino-piperidinyl,

(5) 4-methylpiperazinyl, 4-tert-butoxycarbonylpiperazinyl,

(6) Morpholinyl,

(7) 4-hydroxypiperidin-1-ylsulfonyl, 4-methylpiperazin-1-ylsulfonyl,

(8) 4-(4-Methyl-piperazin-1-yl)piperidin-1-ylcarbonyl, 4-methylpiperazin-1-ylcarbonyl,

(9) pyridin-2-ylmethoxy,

(10) 2-dimethylaminoacetamido,

(11)–F,

(12) Z ₂ and Z ₃ or Z ₃ and Z ₄ form

其中Z₂，Z₃，Z₄，Z₅各自独立地选自：吗啉基，4-甲基哌嗪基，4-羟基哌啶基；2)

wherein Z ₂ , Z ₃ , Z ₄ , and Z ₅ are each independently selected from: morpholinyl, 4-methylpiperazinyl, and 4-hydroxypiperidinyl;

其中Z₁，Z₃，Z₄，Z₅各自独立地选自：吗啉基，4-羟基哌啶基。3)

wherein Z ₁ , Z ₃ , Z ₄ , and Z ₅ are each independently selected from: morpholinyl, 4-hydroxypiperidinyl.

In some embodiments, R1 is selected from:

其中Z₁和Z₅二者之一为氢，另一选自：甲氧基、乙氧基、异丙氧基；1)

Wherein one of Z ₁ and Z ₅ is hydrogen, and the other is selected from: methoxy, ethoxy, isopropoxy;

One of Z ₂ and Z ₄ is hydrogen, the other is methyl, 2-dimethylaminoacetamido,

Z ₃ is selected from: N-methyl-4-piperidinyl, 4-hydroxypiperidinyl, 4-(4-methylpiperazinyl)piperidinyl, 4-(tetrahydropyrrol-1-yl)piperidyl Imidyl, 4-methylpiperazinyl, 4-tert-butoxycarbonylpiperazinyl, morpholinyl, 4-hydroxypiperidin-1-ylsulfonyl, 4-methylpiperazin-1-ylsulfonyl, 4-(4-Methyl-piperazin-1-yl)piperidin-1-ylcarbonyl, 4-methylpiperazin-1-ylcarbonyl, pyridin-2-ylmethoxy, 4-dimethylamino- piperidinyl, -F; or

Z ₂ and Z ₃ or Z ₃ and Z ₄ form

其中Z₃选自：吗啉基，4-甲基哌嗪基，4-羟基哌啶基；Z₁、Z₂和Z₄都为氢；2)

wherein Z ₃ is selected from: morpholinyl, 4-methylpiperazinyl, 4-hydroxypiperidinyl; Z ₁ , Z ₂ and Z ₄ are all hydrogen;

其中Z₃选自：吗啉基，4-羟基哌啶基；Z₁、Z₂和Z₄都为氢。3)

wherein Z ₃ is selected from: morpholinyl, 4-hydroxypiperidinyl; Z ₁ , Z ₂ and Z ₄ are all hydrogen.

In some embodiments, R2 is selected from:

其中A₁，A₂，A₃，A₄，A₅各自独立地选自：(1)氢，(2)异丙基磺酰基。

wherein A ₁ , A ₂ , A ₃ , A ₄ , A ₅ are each independently selected from: (1) hydrogen, (2) isopropylsulfonyl.

其中A₁和A₅二者之一为氢，另一为异丙基磺酰基；A₂，A₃，A₄都为氢。In some embodiments, R2 is selected from:

One of A ₁ and A ₅ is hydrogen, the other is isopropylsulfonyl; A ₂ , A ₃ and A ₄ are all hydrogen.

In a fifth aspect, the present invention provides a compound represented by the following general formula IO, its stereoisomer, its prodrug, its pharmaceutically acceptable salt or its pharmaceutically acceptable solvate,

where R1 is selected from:

1) C1-C6 alkyl, 2-N,N-dimethylaminoethyl, 2-hydroxyethyl, 2-N,N-diethylaminoethyl, 2-N,N-diisopropyl Aminoethyl, 2-morpholinoethyl, 2-(4-methylpiperazinyl)ethyl, 3-N,N-dimethylaminopropyl, 3-N,N-diethylaminopropyl Base, 3-N,N-diisopropylaminopropyl, 3-morpholinylpropyl, 3-(4-methylpiperazinyl)propyl, C3-C6cycloalkyl, 4-N,N -Dimethylaminocyclohexyl, 4-N,N-diethylaminocyclohexyl, N-methyl-4-piperidinyl, N-ethyl-4-piperidinyl, N-isopropyl-4 -Piperidinyl, 1,3-dimethyl-5-pyrazolyl, 1-methyl-4-pyrazolyl, 3-methyl-5-isoxazolinyl, 1-(N-methyl -4-Piperidinyl)-4-pyrazolyl, 1-(N-tert-butoxycarbonyl-4-piperidinyl)-4-pyrazolyl;

其中Z₁，Z₂，Z₃，Z₄，Z₅各自独立地选自：2)

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from:

(1) hydrogen, fluorine, chlorine, bromine, iodine, nitro, cyano,

(2) C1-C6 alkyl, C1-C6 alkoxy, C1-C6 oxygen-containing alkyl, C1-C6 fluorine-containing alkyl, C1-C6 fluorine-containing alkoxy,

(3) piperidinyl, N-methyl-4-piperidinyl, 4-dimethylaminopiperidinyl, 4-N,N-diethylaminopiperidinyl, 4-N,N-diiso propylaminopiperidinyl, 4-hydroxypiperidinyl, 4-(4-methylpiperazinyl)piperidinyl, 4-(4-ethylpiperazinyl)piperidinyl, 4-(4-iso Propylpiperazinyl)piperidinyl, 4-(4-acetylpiperazinyl)piperidinyl, 4-(4-tert-butoxycarbonylpiperazinyl)piperidinyl, 4-(4-methanesulfonyl Piperazinyl)piperidyl, 4-(4-(2-hydroxyethyl)piperazinyl)piperidinyl, 4-(4-(2-cyanoethyl)piperazinyl)piperidinyl, 4 -(4-(3-Hydroxypropyl)piperazinyl)piperidinyl, 4-(4-(2-N,N-dimethylaminoethyl)piperazinyl)piperidinyl, 4-(4 -(2-N,N-Diethylaminoethyl)piperazinyl)piperidinyl, 4-(4-(3-N,N-dimethylaminopropyl)piperazinyl)piperidinyl, 4-(4-(3-N,N-Diethylaminopropyl)piperazinyl)piperidinyl, 4-(tetrahydropyrrolyl)piperidinyl, 4-(3-N,N-dimethyl ylaminotetrahydropyrrolyl)piperidinyl,

(4) 4-methylpiperazinyl, 4-ethylpiperazinyl, 4-isopropylpiperazinyl, 4-acetylpiperazinyl, 4-tert-butoxycarbonylpiperazinyl, 4-methanesulfonic acid Acylpiperazinyl, 4-(2-hydroxyethyl)piperazinyl, 4-(2-cyanoethyl)piperazinyl, 4-(3-hydroxypropyl)piperazinyl, 4-(2- N,N-Dimethylaminoethyl)piperazinyl, 4-(2-N,N-diethylaminoethyl)piperazinyl, 4-(3-N,N-dimethylaminopropyl ) piperazinyl, 4-(3-N,N-diethylaminopropyl)piperazinyl, 4-(N-methyl-4-piperidinyl)piperazinyl, 4-(N-ethyl -4-Piperidinyl)piperazinyl,

(5) N,N-dimethylamino, N,N-diethylamino, N,N-diisopropylamino, 2-N,N-dimethylaminoethylamino, 2-morpholino Ethylamino, 2-(4-methylpiperazinyl)ethylamino, 3-N,N-dimethylaminopropylamino, 3-N,N-diethylaminopropylamino, 3-N ,N-diisopropylaminopropylamino, 3-morpholinopropylamino, 3-(4-methylpiperazinyl)propylamino, N-methylpiperidine-4-amino, N-ethyl piperidine-4-amino, N-isopropylpiperidine-4-amino,

(6) 2-N,N-dimethylaminoethoxy, 2-N,N-diethylaminoethoxy, 2-N,N-diisopropylaminoethoxy, 2-(4 -Methylpiperazinyl)ethoxy, 2-(4-acetylpiperazinyl)ethoxy, 2-morpholinylethoxy, 2-thiophenarinylethoxy, 2-piperidinyl Ethoxy, 3-N,N-dimethylaminopropoxy, 3-N,N-diethylaminopropoxy, 3-N,N-diisopropylaminopropoxy, 3-( 4-Methylpiperazinyl)propoxy, 3-(4-Acetylpiperazinyl)propoxy, 3-morpholinopropoxy, 3-thiophenarinylpropoxy, 3-piperidine pyridin-2-ylmethoxy, pyridin-3-ylmethoxy, pyridin-4-ylmethoxy, phenylmethoxy, monohalogen substituted phenylmethoxy, geminal dihalogen Substituted phenylmethoxy, heterodihalogen substituted phenylmethoxy,

(7) Hydroxysulfonyl, aminosulfonyl, methylaminosulfonyl, ethylaminosulfonyl, propylaminosulfonyl, isopropylaminosulfonyl, cyclopropylaminosulfonyl, cyclobutylaminosulfonyl, cyclopentylamino Sulfonyl, piperidin-1-ylsulfonyl, 4-hydroxypiperidin-1-ylsulfonyl, 4-N,N-dimethylaminopiperidin-1-ylsulfonyl, 4-N,N-di Ethylaminopiperidin-1-ylsulfonyl, tetrahydropyrrolyl-1-sulfonyl, 3-N,N-dimethylaminotetrahydropyrrolyl-1-sulfonyl, 3-N,N-diethyl ylaminotetrahydropyrrolyl-1-sulfonyl, 4-methylpiperazin-1-ylsulfonyl, 4-ethylpiperazinyl-1-sulfonyl, 4-acetylpiperazinyl-1-sulfonyl , 4-tert-butoxycarbonylpiperazinyl-1-sulfonyl, 4-(2-hydroxyethyl)piperazinyl-1-sulfonyl, 4-(2-cyanoethyl)piperazinyl-1- Sulfonyl, 4-(2-N,N-dimethylaminoethyl)piperazinyl-1-sulfonyl, 4-(2-N,N-diethylethyl)piperazinyl-1-sulfonyl Acyl, 4-(3-hydroxypropyl)piperazinyl-1-sulfonyl, 4-(3-N,N-dimethylaminopropyl)piperazinyl-1-sulfonyl, 4-(3- N,N-Diethylaminopropyl)piperazinyl-1-sulfonyl, morpholinyl-1-sulfonyl, 3,5-dimethylmorpholinyl-1-sulfonyl, 4-(4- Methyl-piperazin-1-yl)piperidin-1-ylsulfonyl, 4-(4-ethyl-1-piperazinyl)piperidin-1-ylsulfonyl, 4-(4-acetyl- 1-Piperazinyl)piperidin-1-ylsulfonyl, 4-(N-methyl-4-piperidinyl)piperazinyl-1-sulfonyl,

(8) Hydroxycarbonyl, aminocarbonyl, methylaminocarbonyl, ethylaminocarbonyl, propylaminocarbonyl, isopropylaminocarbonyl, cyclopropylaminocarbonyl, cyclobutylaminocarbonyl, cyclopentylaminocarbonyl, piperidinyl-1- Carbonyl, 4-hydroxypiperidinyl-1-carbonyl, 4-N,N-dimethylaminopiperidinyl-1-carbonyl, 4-N,N-diethylaminopiperidinyl-1-carbonyl, tetra Hydropyrrolyl-1-carbonyl, 3-N,N-dimethylaminotetrahydropyrrolyl-1-carbonyl, 3-N,N-diethylaminotetrahydropyrrolyl-1-carbonyl, 4-methyl Piperazin-1-ylcarbonyl, 4-ethylpiperazinyl-1-carbonyl, 4-acetylpiperazinyl-1-carbonyl, 4-tert-butoxycarbonylpiperazinyl-1-carbonyl, 4-(2 -Hydroxyethyl)piperazinyl-1-carbonyl, 4-(2-cyanoethyl)piperazinyl-1-carbonyl, 4-(2-N,N-dimethylaminoethyl)piperazinyl -1-carbonyl, 4-(2-N,N-diethylaminoethyl)piperazinyl-1-carbonyl, 4-(3-hydroxypropyl)piperazinyl-1-carbonyl, 4-(3 -N,N-Dimethylaminopropyl)piperazinyl-1-carbonyl, 4-(3-N,N-diethylaminopropyl)piperazinyl-1-carbonyl, morpholinyl-1- Carbonyl, 3,5-dimethylmorpholinyl-1-carbonyl, 4-(4-methyl-piperazin-1-yl)piperidin-1-ylcarbonyl, 4-(4-ethyl-1- Piperazinyl)piperidinyl-1-carbonyl, 4-(4-acetyl-1-piperazinyl)piperidinyl-1-carbonyl, 4-(N-methyl-4-piperidinyl)piperazine yl-1-carbonyl, methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, tert-butoxycarbonyl,

(9) carbamoylamino, methylcarbamoylamino, ethylcarbamoylamino, propylcarbamoylamino, isopropylcarbamoylamino, cyclopropylcarbamoylamino, cyclobutylcarbamoylamino, cyclo Amylcarbamoylamino, piperidinyl-1-carboxamido, 4-hydroxypiperidinyl-1-carboxamido, 4-N,N-dimethylaminopiperidinyl-1-carboxamido, 4-N,N-Diethylaminopiperidinyl-1-carboxamido, tetrahydropyrrolyl-1-carboxamido, 3-N,N-dimethylaminotetrahydropyrrolyl-1-carboxyl Amino, 3-N,N-diethylaminotetrahydropyrrolyl-1-carboxamido, 4-methylpiperazinyl-1-carboxamido, 4-ethylpiperazinyl-1-carboxamido , 4-Acetyl piperazinyl-1-carboxamido, 4-tert-butoxycarbonyl piperazinyl-1-carboxamido, 4-(2-hydroxyethyl) piperazinyl-1-carboxamido, 4-(2-cyanoethyl)piperazinyl-1-carboxamido, 4-(2-N,N-dimethylaminoethyl)piperazinyl-1-carboxamido, 4-(2 -N,N-Diethylaminoethyl)piperazinyl-1-carboxamido, 4-(3-hydroxypropyl)piperazinyl-1-carboxamido, 4-(3-N,N- Dimethylaminopropyl)piperazinyl-1-carboxamido, 4-(3-N,N-diethylaminopropyl)piperazinyl-1-carboxamido, morpholino-1-methyl amido, 3,5-dimethylmorpholino-1-carboxamido, 4-(4-methyl-piperazin-1-yl)piperidinyl-1-carboxamido, 4-(4- Ethyl-1-piperazinyl)piperidinyl-1-carboxamido, 4-(4-acetyl-1-piperazinyl)piperidinyl-1-carboxamido, 4-(N-methyl -4-Piperidinyl)piperazinyl-1-carboxamido; or

(10) Z ₂ and Z ₃ or Z ₃ and Z ₄ form a nitrogen- or oxygen-containing substituted or unsubstituted five-membered ring or six-membered ring, and the substituents can be selected from the same substituents as Z ₁ ;

其中A₁，A₂，A₃，A₄，A₅各自独立地选自：R2 is selected from

wherein A ₁ , A ₂ , A ₃ , A ₄ , A ₅ are each independently selected from:

(1) hydrogen, fluorine, chlorine, bromine, iodine, cyano, trifluoromethyl, trifluoromethoxy, nitro,

(2) Methylthio, ethylthio, isopropylthio, methylsulfinyl, ethylsulfinyl, isopropylsulfinyl, methylsulfonyl, ethylsulfonyl, isopropylsulfonyl, tert-butanesulfonyl , methanesulfonylamino, methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, tert-butoxycarbonyl, methylaminocarbonyl, ethyl Aminocarbonyl, propylaminocarbonyl, isopropylaminocarbonyl, cyclopropylaminocarbonyl, cyclobutylaminocarbonyl, cyclopentylaminocarbonyl, dimethylphosphinoyl, diethylphosphinoyl, diisopropylphosphine Acyl.

其中Z₁，Z₂，Z₃，Z₄，Z₅各自独立地选自：In some embodiments, R1 is selected from

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from:

(1) Hydrogen,

(2) C1-C6 alkoxy,

(3) piperidinyl, N-methyl-4-piperidinyl, 4--dimethylaminopiperidinyl, 4-N,N-diethylaminopiperidinyl, 4-N,N-diethylaminopiperidinyl Isopropylaminopiperidinyl, 4-hydroxypiperidinyl, 4-(4-methylpiperazinyl)piperidinyl, 4-(4-ethylpiperazinyl)piperidinyl, 4-(4- Isopropylpiperazinyl)piperidinyl, 4-(4-acetylpiperazinyl)piperidinyl, 4-(4-tert-butoxycarbonylpiperazinyl)piperidinyl, 4-(4-methanesulfonyl) acylpiperazinyl)piperidyl, 4-(4-(2-hydroxyethyl)piperazinyl)piperidinyl, 4-(4-(2-cyanoethyl)piperazinyl)piperidinyl, 4-(4-(3-Hydroxypropyl)piperazinyl)piperidinyl, 4-(4-(2-N,N-dimethylaminoethyl)piperazinyl)piperidinyl, 4-( 4-(2-N,N-Diethylaminoethyl)piperazinyl)piperidinyl, 4-(4-(3-N,N-dimethylaminopropyl)piperazinyl)piperidinyl , 4-(4-(3-N,N-diethylaminopropyl)piperazinyl)piperidinyl, 4-(tetrahydropyrrolyl)piperidinyl, 4-(3-N,N-di Methylaminotetrahydropyrrolyl)piperidinyl,

(4) 4-methylpiperazinyl, 4-ethylpiperazinyl, 4-isopropylpiperazinyl, 4-acetylpiperazinyl, 4-tert-butoxycarbonylpiperazinyl, 4-methanesulfonic acid Acylpiperazinyl, 4-(2-hydroxyethyl)piperazinyl, 4-(2-cyanoethyl)piperazinyl, 4-(3-hydroxypropyl)piperazinyl, 4-(2- N,N-Dimethylaminoethyl)piperazinyl, 4-(2-N,N-diethylaminoethyl)piperazinyl, 4-(3-N,N-dimethylaminopropyl ) piperazinyl, 4-(3-N,N-diethylaminopropyl)piperazinyl, 4-(N-methyl-4-piperidinyl)piperazinyl, 4-(N-ethyl -4-Piperidinyl)piperazinyl or

(5) Z ₂ and Z ₃ or Z ₃ and Z ₄ form a nitrogen- or oxygen-containing substituted or unsubstituted five-membered ring, and the substituents may be selected from the same substituents as those of Z ₁ .

In some embodiments, R1 is selected from:

其中Z₁，Z₂，Z₃，Z₄，Z₅各自独立地任选自：

Wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from:

(1) Hydrogen,

(2) C1-C6 alkoxy

(3) 4-(4-methylpiperazin-1-yl) piperidinyl, 4-methylpiperazinyl, 4-dimethylamino-piperidinyl,

(4) Z ₂ and Z ₃ can form a nitrogen-containing substituted or unsubstituted five-membered ring

其中，In some embodiments, R1 is selected from:

in,

Z ₁ is methoxy, and Z ₃ is selected from: 4-dimethylamino-piperidinyl, 4-methylpiperazinyl, 4-(4-methylpiperazinyl)piperidinyl, and the rest are hydrogen; or

且Z₁为甲氧基，其余为氢。Z ₃ is formed with Z ₄

And Z ₁ is methoxy, and the rest are hydrogen.

其中A₁，A₂，A₃，A₄，A₅各自独立地选自：In some embodiments, R2 is selected from

wherein A ₁ , A ₂ , A ₃ , A ₄ , A ₅ are each independently selected from:

(1) hydrogen; (2) tert-butanesulfonyl.

其中A₁和A₅二者之一为氢，另一为叔丁磺酰基；A₂，A₃，A₄都为氢。In some embodiments, R2 is selected from:

One of A ₁ and A ₅ is hydrogen, the other is tert-butanesulfonyl; A ₂ , A ₃ and A ₄ are all hydrogen.

In a sixth aspect, the present invention provides a compound represented by the following general formula IC, its stereoisomer, its prodrug, its pharmaceutically acceptable salt or its pharmaceutically acceptable solvate,

where R1 is selected from:

1) C1-C6 alkyl, 2-N,N-dimethylaminoethyl, 2-hydroxyethyl, 2-N,N-diethylaminoethyl, 2-N,N-diisopropyl Aminoethyl, 2-morpholinoethyl, 2-(4-methylpiperazinyl)ethyl, 3-N,N-dimethylaminopropyl, 3-N,N-diethylaminopropyl Base, 3-N,N-diisopropylaminopropyl, 3-morpholinylpropyl, 3-(4-methylpiperazinyl)propyl, C3-C6cycloalkyl, 4-N,N -Dimethylaminocyclohexyl, 4-N,N-diethylaminocyclohexyl, N-methyl-4-piperidinyl, N-ethyl-4-piperidinyl, N-isopropyl-4 -Piperidinyl, 1,3-dimethyl-5-pyrazolyl, 1-methyl-4-pyrazolyl, 3-methyl-5-isoxazolinyl, 1-(N-methyl -4-Piperidinyl)-4-pyrazolyl, 1-(N-tert-butoxycarbonyl-4-piperidinyl)-4-pyrazolyl;

其中Z₁，Z₂，Z₃，Z₄，Z₅各自独立地选自：2)

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from:

(1) hydrogen, fluorine, chlorine, bromine, iodine, nitro, cyano,

(2) C1-C6 alkyl, C1-C6 alkoxy, C1-C6 oxygen-containing alkyl, C1-C6 fluorine-containing alkyl, C1-C6 fluorine-containing alkoxy

(3) piperidinyl, N-methyl-4-piperidinyl, 4-N,N-dimethylaminopiperidinyl, 4-N,N-diethylaminopiperidinyl, 4-N, N-diisopropylaminopiperidinyl, 4-hydroxypiperidinyl, 4-(4-methylpiperazinyl)piperidinyl, 4-(4-ethylpiperazinyl)piperidinyl, 4- (4-Isopropylpiperazinyl)piperidinyl, 4-(4-acetylpiperazinyl)piperidinyl, 4-(4-tert-butoxycarbonylpiperazinyl)piperidinyl, 4-(4 -Methylsulfonylpiperazinyl)piperidyl, 4-(4-(2-hydroxyethyl)piperazinyl)piperidyl, 4-(4-(2-cyanoethyl)piperazinyl)piperidyl pyridyl, 4-(4-(3-hydroxypropyl)piperazinyl)piperidinyl, 4-(4-(2-N,N-dimethylaminoethyl)piperazinyl)piperidinyl, 4-(4-(2-N,N-Diethylaminoethyl)piperazinyl)piperidyl, 4-(4-(3-N,N-dimethylaminopropyl)piperazinyl) piperidinyl, 4-(4-(3-N,N-diethylaminopropyl)piperazinyl)piperidinyl, 4-(tetrahydropyrrolyl)piperidinyl, 4-(3-N, N-dimethylaminotetrahydropyrrolyl) piperidinyl,

(4) 4-methylpiperazinyl, 4-ethylpiperazinyl, 4-isopropylpiperazinyl, 4-acetylpiperazinyl, 4-tert-butoxycarbonylpiperazinyl, 4-methanesulfonic acid Acylpiperazinyl, 4-(2-hydroxyethyl)piperazinyl, 4-(2-cyanoethyl)piperazinyl, 4-(3-hydroxypropyl)piperazinyl, 4-(2- N,N-Dimethylaminoethyl)piperazinyl, 4-(2-N,N-diethylaminoethyl)piperazinyl, 4-(3-N,N-dimethylaminopropyl ) piperazinyl, 4-(3-N,N-diethylaminopropyl)piperazinyl, 4-(N-methyl-4-piperidinyl)piperazinyl, 4-(N-ethyl -4-Piperidinyl)piperazinyl, or

(5) N,N-dimethylamino, N,N-diethylamino, N,N-diisopropylamino, 2-N,N-dimethylaminoethylamino, 2-morpholino Ethylamino, 2-(4-methylpiperazinyl)ethylamino, 3-N,N-dimethylaminopropylamino, 3-N,N-diethylaminopropylamino, 3-N ,N-diisopropylaminopropylamino, 3-morpholinopropylamino, 3-(4-methylpiperazinyl)propylamino, N-methylpiperidine-4-amino, N-ethyl piperidine-4-amino, N-isopropylpiperidine-4-amino,

(6) 2-N,N-dimethylaminoethoxy, 2-N,N-diethylaminoethoxy, 2-N,N-diisopropylaminoethoxy, 2-(4 -Methylpiperazinyl)ethoxy, 2-(4-acetylpiperazinyl)ethoxy, 2-morpholinylethoxy, 2-thiophenarinylethoxy, 2-piperidinyl Ethoxy, 3-N,N-dimethylaminopropoxy, 3-N,N-diethylaminopropoxy, 3-N,N-diisopropylaminopropoxy, 3-( 4-Methylpiperazinyl)propoxy, 3-(4-Acetylpiperazinyl)propoxy, 3-morpholinopropoxy, 3-thiophenarinylpropoxy, 3-piperidine pyridin-2-ylmethoxy, pyridin-3-ylmethoxy, pyridin-4-ylmethoxy, phenylmethoxy, monohalogen substituted phenylmethoxy, geminal dihalogen Substituted phenylmethoxy, heterodihalogen substituted phenylmethoxy,

(7) Hydroxysulfonyl, aminosulfonyl, methylaminosulfonyl, ethylaminosulfonyl, propylaminosulfonyl, isopropylaminosulfonyl, cyclopropylaminosulfonyl, cyclobutylaminosulfonyl, cyclopentylamino Sulfonyl, piperidin-1-ylsulfonyl, 4-hydroxypiperidin-1-ylsulfonyl, 4-N,N-dimethylaminopiperidin-1-ylsulfonyl, 4-N,N-di Ethylaminopiperidin-1-ylsulfonyl, tetrahydropyrrolyl-1-sulfonyl, 3-N,N-dimethylaminotetrahydropyrrolyl-1-sulfonyl, 3-N,N-diethyl ylaminotetrahydropyrrolyl-1-sulfonyl, 4-methylpiperazin-1-ylsulfonyl, 4-ethylpiperazinyl-1-sulfonyl, 4-acetylpiperazinyl-1-sulfonyl , 4-tert-butoxycarbonylpiperazinyl-1-sulfonyl, 4-(2-hydroxyethyl)piperazinyl-1-sulfonyl, 4-(2-cyanoethyl)piperazinyl-1- Sulfonyl, 4-(2-N,N-dimethylaminoethyl)piperazinyl-1-sulfonyl, 4-(2-N,N-diethylethyl)piperazinyl-1-sulfonyl Acyl, 4-(3-hydroxypropyl)piperazinyl-1-sulfonyl, 4-(3-N,N-dimethylaminopropyl)piperazinyl-1-sulfonyl, 4-(3- N,N-Diethylaminopropyl)piperazinyl-1-sulfonyl, morpholinyl-1-sulfonyl, 3,5-dimethylmorpholinyl-1-sulfonyl, 4-(4- Methyl-piperazin-1-yl)piperidin-1-ylsulfonyl, 4-(4-ethyl-1-piperazinyl)piperidin-1-ylsulfonyl, 4-(4-acetyl- 1-Piperazinyl)piperidin-1-ylsulfonyl, 4-(N-methyl-4-piperidinyl)piperazinyl-1-sulfonyl,

(8) Hydroxycarbonyl, aminocarbonyl, methylaminocarbonyl, ethylaminocarbonyl, propylaminocarbonyl, isopropylaminocarbonyl, cyclopropylaminocarbonyl, cyclobutylaminocarbonyl, cyclopentylaminocarbonyl, piperidinyl-1- Carbonyl, 4-hydroxypiperidinyl-1-carbonyl, 4-N,N-dimethylaminopiperidinyl-1-carbonyl, 4-N,N-diethylaminopiperidinyl-1-carbonyl, tetra Hydropyrrolyl-1-carbonyl, 3-N,N-dimethylaminotetrahydropyrrolyl-1-carbonyl, 3-N,N-diethylaminotetrahydropyrrolyl-1-carbonyl, 4-methyl Piperazin-1-ylcarbonyl, 4-ethylpiperazinyl-1-carbonyl, 4-acetylpiperazinyl-1-carbonyl, 4-tert-butoxycarbonylpiperazinyl-1-carbonyl, 4-(2 -Hydroxyethyl)piperazinyl-1-carbonyl, 4-(2-cyanoethyl)piperazinyl-1-carbonyl, 4-(2-N,N-dimethylaminoethyl)piperazinyl -1-carbonyl, 4-(2-N,N-diethylaminoethyl)piperazinyl-1-carbonyl, 4-(3-hydroxypropyl)piperazinyl-1-carbonyl, 4-(3 -N,N-Dimethylaminopropyl)piperazinyl-1-carbonyl, 4-(3-N,N-diethylaminopropyl)piperazinyl-1-carbonyl, morpholinyl-1- Carbonyl, 3,5-dimethylmorpholinyl-1-carbonyl, 4-(4-methyl-piperazin-1-yl)piperidin-1-ylcarbonyl, 4-(4-ethyl-1- Piperazinyl)piperidinyl-1-carbonyl, 4-(4-acetyl-1-piperazinyl)piperidinyl-1-carbonyl, 4-(N-methyl-4-piperidinyl)piperazine yl-1-carbonyl, methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, tert-butoxycarbonyl,

(9) carbamoylamino, methylcarbamoylamino, ethylcarbamoylamino, propylcarbamoylamino, isopropylcarbamoylamino, cyclopropylcarbamoylamino, cyclobutylcarbamoylamino, cyclo Amylcarbamoylamino, piperidinyl-1-carboxamido, 4-hydroxypiperidinyl-1-carboxamido, 4-N,N-dimethylaminopiperidinyl-1-carboxamido, 4-N,N-Diethylaminopiperidinyl-1-carboxamido, tetrahydropyrrolyl-1-carboxamido, 3-N,N-dimethylaminotetrahydropyrrolyl-1-carboxyl Amino, 3-N,N-diethylaminotetrahydropyrrolyl-1-carboxamido, 4-methylpiperazinyl-1-carboxamido, 4-ethylpiperazinyl-1-carboxamido , 4-Acetyl piperazinyl-1-carboxamido, 4-tert-butoxycarbonyl piperazinyl-1-carboxamido, 4-(2-hydroxyethyl) piperazinyl-1-carboxamido, 4-(2-cyanoethyl)piperazinyl-1-carboxamido, 4-(2-N,N-dimethylaminoethyl)piperazinyl-1-carboxamido, 4-(2 -N,N-Diethylaminoethyl)piperazinyl-1-carboxamido, 4-(3-hydroxypropyl)piperazinyl-1-carboxamido, 4-(3-N,N- Dimethylaminopropyl)piperazinyl-1-carboxamido, 4-(3-N,N-diethylaminopropyl)piperazinyl-1-carboxamido, morpholino-1-methyl amido, 3,5-dimethylmorpholino-1-carboxamido, 4-(4-methyl-piperazin-1-yl)piperidinyl-1-carboxamido, 4-(4- Ethyl-1-piperazinyl)piperidinyl-1-carboxamido, 4-(4-acetyl-1-piperazinyl)piperidinyl-1-carboxamido, 4-(N-methyl -4-Piperidinyl)piperazinyl-1-carboxamido

(10) Z ₂ and Z ₃ or Z ₃ and Z ₄ form a nitrogen- or oxygen-containing substituted or unsubstituted five-membered ring, and the substituents can be selected from the same substituents as Z ₁ ;

R2 is selected from: 1)

where Y is an NH, S or O atom,

A ₆ , A ₇ , A ₈ , A ₉ , A ₁₀ , A ₁₁ are each independently selected from:

(1) hydrogen, fluorine, chlorine, bromine, iodine, cyano, trifluoromethyl, trifluoromethoxy, nitro,

(2) Methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, tert-butoxycarbonyl, methylaminocarbonyl, ethylaminocarbonyl, Propylaminocarbonyl, isopropylaminocarbonyl, cyclopropylaminocarbonyl, cyclobutylaminocarbonyl, cyclopentylaminocarbonyl;

2)

where A ₁₂ is selected from:

(1) hydrogen, fluorine, chlorine, bromine, iodine, cyano, trifluoromethyl, trifluoromethoxy, nitro,

(2) Methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, tert-butoxycarbonyl, methylaminocarbonyl, ethylaminocarbonyl, Propylaminocarbonyl, isopropylaminocarbonyl, cyclopropylaminocarbonyl, cyclobutylaminocarbonyl, cyclopentylaminocarbonyl, methylsulfinyl, ethylsulfinyl, isopropylsulfinyl, methylsulfonyl , ethylsulfonyl, isopropylsulfonyl;

Y ₂ , Y ₃ , Y ₄ are the following combinations:

Y ₂ is C, Y ₃ is NA ₁₃ , Y ₄ is N, or

Y ₂ is N, Y ₃ is NA ₁₃ , and Y ₄ is CH or N;

wherein A ₁₃ is hydrogen, C1-C6 alkyl.

In some embodiments, R1 is selected from:

其中Z₁，Z₂，Z₃，Z₄，Z₅各自独立地选自：

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from:

(1) Hydrogen,

(2) C1-C6 alkoxy,

(3) 4-Hydroxypiperidinyl, piperidinyl, N-methyl-4-piperidinyl, 4-N,N-dimethylaminopiperidinyl, 4-N,N-diethylaminopiperidyl pyridyl, 4-N,N-diisopropylaminopiperidinyl,

(4) 4-methylpiperazinyl, 4-ethylpiperazinyl, 4-isopropylpiperazinyl, 4-acetylpiperazinyl, 4-tert-butoxycarbonylpiperazinyl, 4-methanesulfonic acid Acylpiperazinyl, 4-(2-hydroxyethyl)piperazinyl, 4-(2-cyanoethyl)piperazinyl, 4-(3-hydroxypropyl)piperazinyl, 4-(2- N,N-Dimethylaminoethyl)piperazinyl, 4-(2-N,N-diethylaminoethyl)piperazinyl, 4-(3-N,N-dimethylaminopropyl ) piperazinyl, 4-(3-N,N-diethylaminopropyl)piperazinyl, 4-(N-methyl-4-piperidinyl)piperazinyl, 4-(N-ethyl -4-Piperidinyl)piperazinyl,

(5) 4-(4-Methylpiperazinyl)piperidinyl, 4-(4-ethylpiperazinyl)piperidinyl, 4-(4-isopropylpiperazinyl)piperidinyl, 4 -(4-Acetylpiperazinyl)piperidinyl, 4-(4-tert-butoxycarbonylpiperazinyl)piperidinyl, 4-(4-methanesulfonylpiperazinyl)piperidinyl, 4-( 4-(2-Hydroxyethyl)piperazinyl)piperidinyl, 4-(4-(2-cyanoethyl)piperazinyl)piperidinyl, 4-(4-(3-hydroxypropyl) Piperazinyl) piperidinyl, 4-(4-(2-N,N-dimethylaminoethyl)piperazinyl)piperidinyl, 4-(4-(2-N,N-diethyl) Aminoethyl)piperazinyl)piperidinyl, 4-(4-(3-N,N-dimethylaminopropyl)piperazinyl)piperidinyl, 4-(4-(3-N,N -Diethylaminopropyl)piperazinyl)piperidinyl, 4-(tetrahydropyrrolyl)piperidinyl, 4-(3-N,N-dimethylaminotetrahydropyrrolyl)piperidinyl, or

(6) Z ₂ and Z ₃ or Z ₃ and Z ₄ form a nitrogen- or oxygen-containing substituted or unsubstituted five-membered ring, and the substituents can be selected from the same substituents as those of Z ₁ .

In some embodiments, R1 is selected from:

其中Z₁，Z₂，Z₃，Z₄，Z₅各自独立地选自：

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from:

(1) Hydrogen,

(2) Methoxy,

(3) 4-hydroxypiperidinyl,

(4) 4-methylpiperazinyl,

(5) 4-(4-Methylpiperazinyl)piperidinyl, or

(6) Z ₂ and Z ₃ or Z ₃ and Z ₄ form

In some embodiments, R1 is selected from:

其中Z₁和Z₅二者之一为氢，另一为甲氧基，Z₄为氢；

Wherein one of Z ₁ and Z ₅ is hydrogen, the other is methoxy, and Z ₄ is hydrogen;

Z ₃ is selected from: 4-hydroxypiperidinyl, 4-methylpiperazinyl, 4-(4-methylpiperazinyl)piperidinyl, or

Z ₂ is formed with Z ₃

In some embodiments, R2 is selected from:

where A ₁₂ is selected from:

(1) Hydrogen, methyl, fluorine, chlorine, bromine, iodine, cyano, trifluoromethyl, trifluoromethoxy, nitro,

(2) Methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, tert-butoxycarbonyl, methylaminocarbonyl, ethylaminocarbonyl, Propylaminocarbonyl, isopropylaminocarbonyl, cyclopropylaminocarbonyl, cyclobutylaminocarbonyl, cyclopentylaminocarbonyl, methylsulfinyl, ethylsulfinyl, isopropylsulfinyl, methylsulfonyl , ethylsulfonyl, isopropylsulfonyl;

Y ₂ , Y ₃ , Y ₄ are the following combinations:

Y ₂ is C, Y ₃ is NA ₁₃ , Y ₄ is N, or

Y ₂ is N, Y ₃ is NA ₁₃ , and Y ₄ is CH or N;

wherein A ₁₃ is hydrogen, C1-C6 alkyl.

In some embodiments, R2 is selected from:

where A ₁₂ is selected from:

(1) hydrogen, methyl,

(2) isopropylsulfonyl;

Y ₂ , Y ₃ , Y ₄ are the following combinations:

Y ₂ is C, Y ₃ is NA ₁₃ , Y ₄ is N,

wherein A ₁₃ is hydrogen, C1-C6 alkyl.

In some embodiments, R2 is selected from:

wherein A ₁₂ is selected from isopropylsulfonyl;

Y ₂ , Y ₃ , Y ₄ are the following combinations: Y ₂ is C, Y ₃ is NA ₁₃ , Y ₄ is N, and A ₁₃ is methyl.

In a seventh aspect, the present invention provides a compound represented by the following general formula ID, its stereoisomer, its prodrug, its pharmaceutically acceptable salt or its pharmaceutically acceptable solvate,

where R1 is selected from:

1) C1-C6 alkyl, 2-N,N-dimethylaminoethyl, 2-hydroxyethyl, 2-N,N-diethylaminoethyl, 2-N,N-diisopropyl Aminoethyl, 2-morpholinoethyl, 2-(4-methylpiperazinyl)ethyl, 3-N,N-dimethylaminopropyl, 3-N,N-diethylaminopropyl Base, 3-N,N-diisopropylaminopropyl, 3-morpholinylpropyl, 3-(4-methylpiperazinyl)propyl, C3-C6cycloalkyl, 4-N,N -Dimethylaminocyclohexyl, 4-N,N-diethylaminocyclohexyl, N-methyl-4-piperidinyl, N-ethyl-4-piperidinyl, N-isopropyl-4 -Piperidinyl, 1,3-dimethyl-5-pyrazolyl, 1-methyl-4-pyrazolyl, 3-methyl-5-isoxazolinyl, 1-(N-methyl -4-Piperidinyl)-4-pyrazolyl, 1-(N-tert-butoxycarbonyl-4-piperidinyl)-4-pyrazolyl;

其中Z₁，Z₂，Z₃，Z₄，Z₅各自独立地选自：2)

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from:

(1) hydrogen, fluorine, chlorine, bromine, iodine, nitro, cyano,

(2) C1-C6 alkyl, C1-C6 alkoxy, C1-C6 oxygen-containing alkyl, C1-C6 fluorine-containing alkyl, C1-C6 fluorine-containing alkoxy,

(3) piperidinyl, N-methyl-4-piperidinyl, 4-N,N-dimethylaminopiperidinyl, 4-N,N-diethylaminopiperidinyl, 4-N, N-diisopropylaminopiperidinyl, 4-hydroxypiperidinyl, 4-(4-methylpiperazinyl)piperidinyl, 4-(4-ethylpiperazinyl)piperidinyl, 4- (4-Isopropylpiperazinyl)piperidinyl, 4-(4-acetylpiperazinyl)piperidinyl, 4-(4-tert-butoxycarbonylpiperazinyl)piperidinyl, 4-(4 -Methylsulfonylpiperazinyl)piperidyl, 4-(4-(2-hydroxyethyl)piperazinyl)piperidyl, 4-(4-(2-cyanoethyl)piperazinyl)piperidyl pyridyl, 4-(4-(3-hydroxypropyl)piperazinyl)piperidinyl, 4-(4-(2-N,N-dimethylaminoethyl)piperazinyl)piperidinyl, 4-(4-(2-N,N-Diethylaminoethyl)piperazinyl)piperidyl, 4-(4-(3-N,N-dimethylaminopropyl)piperazinyl) piperidinyl, 4-(4-(3-N,N-diethylaminopropyl)piperazinyl)piperidinyl, 4-(tetrahydropyrrolyl)piperidinyl, 4-(3-N, N-dimethylaminotetrahydropyrrolyl) piperidinyl,

(4) 4-methylpiperazinyl, 4-ethylpiperazinyl, 4-isopropylpiperazinyl, 4-acetylpiperazinyl, 4-tert-butoxycarbonylpiperazinyl, 4-methanesulfonic acid Acylpiperazinyl, 4-(2-hydroxyethyl)piperazinyl, 4-(2-cyanoethyl)piperazinyl, 4-(3-hydroxypropyl)piperazinyl, 4-(2- N,N-Dimethylaminoethyl)piperazinyl, 4-(2-N,N-diethylaminoethyl)piperazinyl, 4-(3-N,N-dimethylaminopropyl ) piperazinyl, 4-(3-N,N-diethylaminopropyl)piperazinyl, 4-(N-methyl-4-piperidinyl)piperazinyl, 4-(N-ethyl -4-Piperidinyl)piperazinyl,

(5) N,N-dimethylamino, N,N-diethylamino, N,N-diisopropylamino, 2-N,N-dimethylaminoethylamino, 2-morpholino Ethylamino, 2-(4-methylpiperazinyl)ethylamino, 3-N,N-dimethylaminopropylamino, 3-N,N-diethylaminopropylamino, 3-N ,N-diisopropylaminopropylamino, 3-morpholinopropylamino, 3-(4-methylpiperazinyl)propylamino, N-methylpiperidine-4-amino, N-ethyl piperidine-4-amino, N-isopropylpiperidine-4-amino,

(6) 2-N,N-dimethylaminoethoxy, 2-N,N-diethylaminoethoxy, 2-N,N-diisopropylaminoethoxy, 2-(4 -Methylpiperazinyl)ethoxy, 2-(4-acetylpiperazinyl)ethoxy, 2-morpholinylethoxy, 2-thiophenarinylethoxy, 2-piperidinyl Ethoxy, 3-N,N-dimethylaminopropoxy, 3-N,N-diethylaminopropoxy, 3-N,N-diisopropylaminopropoxy, 3-( 4-Methylpiperazinyl)propoxy, 3-(4-Acetylpiperazinyl)propoxy, 3-morpholinopropoxy, 3-thiophenarinylpropoxy, 3-piperidine pyridin-2-ylmethoxy, pyridin-3-ylmethoxy, pyridin-4-ylmethoxy, phenylmethoxy, monohalogen substituted phenylmethoxy, geminal dihalogen Substituted phenylmethoxy, heterodihalogen substituted phenylmethoxy,

(7) Hydroxysulfonyl, aminosulfonyl, methylaminosulfonyl, ethylaminosulfonyl, propylaminosulfonyl, isopropylaminosulfonyl, cyclopropylaminosulfonyl, cyclobutylaminosulfonyl, cyclopentylamino Sulfonyl, piperidin-1-ylsulfonyl, 4-hydroxypiperidin-1-ylsulfonyl, 4-N,N-dimethylaminopiperidin-1-ylsulfonyl, 4-N,N-di Ethylaminopiperidin-1-ylsulfonyl, tetrahydropyrrolyl-1-sulfonyl, 3-N,N-dimethylaminotetrahydropyrrolyl-1-sulfonyl, 3-N,N-diethyl ylaminotetrahydropyrrolyl-1-sulfonyl, 4-methylpiperazin-1-ylsulfonyl, 4-ethylpiperazinyl-1-sulfonyl, 4-acetylpiperazinyl-1-sulfonyl , 4-tert-butoxycarbonylpiperazinyl-1-sulfonyl, 4-(2-hydroxyethyl)piperazinyl-1-sulfonyl, 4-(2-cyanoethyl)piperazinyl-1- Sulfonyl, 4-(2-N,N-dimethylaminoethyl)piperazinyl-1-sulfonyl, 4-(2-N,N-diethylethyl)piperazinyl-1-sulfonyl Acyl, 4-(3-hydroxypropyl)piperazinyl-1-sulfonyl, 4-(3-N,N-dimethylaminopropyl)piperazinyl-1-sulfonyl, 4-(3- N,N-Diethylaminopropyl)piperazinyl-1-sulfonyl, morpholinyl-1-sulfonyl, 3,5-dimethylmorpholinyl-1-sulfonyl, 4-(4- Methyl-piperazin-1-yl)piperidin-1-ylsulfonyl, 4-(4-ethyl-1-piperazinyl)piperidin-1-ylsulfonyl, 4-(4-acetyl- 1-Piperazinyl)piperidin-1-ylsulfonyl, 4-(N-methyl-4-piperidinyl)piperazinyl-1-sulfonyl,

(8) Hydroxycarbonyl, aminocarbonyl, methylaminocarbonyl, ethylaminocarbonyl, propylaminocarbonyl, isopropylaminocarbonyl, cyclopropylaminocarbonyl, cyclobutylaminocarbonyl, cyclopentylaminocarbonyl, piperidinyl-1- Carbonyl, 4-Hydroxypiperidinyl-1-carbonyl, 4-N,N-Dimethylaminopiperidinyl-1-carbonyl, 4-N,N-Diethylaminopiperidinyl-1-carbonyl, Tetra Hydropyrrolyl-1-carbonyl, 3-N,N-dimethylaminotetrahydropyrrolyl-1-carbonyl, 3-N,N-diethylaminotetrahydropyrrolyl-1-carbonyl, 4-methyl Piperazin-1-ylcarbonyl, 4-ethylpiperazinyl-1-carbonyl, 4-acetylpiperazinyl-1-carbonyl, 4-tert-butoxycarbonylpiperazinyl-1-carbonyl, 4-(2 -Hydroxyethyl)piperazinyl-1-carbonyl, 4-(2-cyanoethyl)piperazinyl-1-carbonyl, 4-(2-N,N-dimethylaminoethyl)piperazinyl -1-carbonyl, 4-(2-N,N-diethylaminoethyl)piperazinyl-1-carbonyl, 4-(3-hydroxypropyl)piperazinyl-1-carbonyl, 4-(3 -N,N-Dimethylaminopropyl)piperazinyl-1-carbonyl, 4-(3-N,N-diethylaminopropyl)piperazinyl-1-carbonyl, morpholinyl-1- Carbonyl, 3,5-dimethylmorpholinyl-1-carbonyl, 4-(4-methyl-piperazin-1-yl)piperidin-1-ylcarbonyl, 4-(4-ethyl-1- Piperazinyl)piperidinyl-1-carbonyl, 4-(4-acetyl-1-piperazinyl)piperidinyl-1-carbonyl, 4-(N-methyl-4-piperidinyl)piperazine yl-1-carbonyl, methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, tert-butoxycarbonyl,

(9) carbamoylamino, methylcarbamoylamino, ethylcarbamoylamino, propylcarbamoylamino, isopropylcarbamoylamino, cyclopropylcarbamoylamino, cyclobutylcarbamoylamino, cyclo Amylcarbamoylamino, piperidinyl-1-carboxamido, 4-hydroxypiperidinyl-1-carboxamido, 4-N,N-dimethylaminopiperidinyl-1-carboxamido, 4-N,N-Diethylaminopiperidinyl-1-carboxamido, tetrahydropyrrolyl-1-carboxamido, 3-N,N-dimethylaminotetrahydropyrrolyl-1-carboxyl Amino, 3-N,N-diethylaminotetrahydropyrrolyl-1-carboxamido, 4-methylpiperazinyl-1-carboxamido, 4-ethylpiperazinyl-1-carboxamido , 4-Acetyl piperazinyl-1-carboxamido, 4-tert-butoxycarbonyl piperazinyl-1-carboxamido, 4-(2-hydroxyethyl) piperazinyl-1-carboxamido, 4-(2-cyanoethyl)piperazinyl-1-carboxamido, 4-(2-N,N-dimethylaminoethyl)piperazinyl-1-carboxamido, 4-(2 -N,N-Diethylaminoethyl)piperazinyl-1-carboxamido, 4-(3-hydroxypropyl)piperazinyl-1-carboxamido, 4-(3-N,N- Dimethylaminopropyl)piperazinyl-1-carboxamido, 4-(3-N,N-diethylaminopropyl)piperazinyl-1-carboxamido, morpholino-1-methyl amido, 3,5-dimethylmorpholino-1-carboxamido, 4-(4-methyl-piperazin-1-yl)piperidinyl-1-carboxamido, 4-(4- Ethyl-1-piperazinyl)piperidinyl-1-carboxamido, 4-(4-acetyl-1-piperazinyl)piperidinyl-1-carboxamido, 4-(N-methyl -4-Piperidinyl)piperazinyl-1-carboxamido; or

(10) Z ₂ and Z ₃ or Z ₃ and Z ₄ form a nitrogen- or oxygen-containing substituted or unsubstituted five-membered ring or six-membered ring, and the substituents can be selected from the same substituents as those of Z ₁ ;

其中A₁，A₂，A₃，A₄，A₅各自独立地选自：R2 is selected from

wherein A ₁ , A ₂ , A ₃ , A ₄ , A ₅ are each independently selected from:

(1) hydrogen, fluorine, chlorine, bromine, iodine, cyano, trifluoromethyl, trifluoromethoxy, nitro,

(2) methylthio, ethylthio, isopropylthio, methylsulfinyl, ethylsulfinyl, isopropylsulfinyl, methylsulfonyl, ethylsulfonyl, isopropylsulfonyl, methanesulfonylamino , methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, tert-butoxycarbonyl, methylaminocarbonyl, ethylaminocarbonyl, propylamino Carbonyl, isopropylaminocarbonyl, cyclopropylaminocarbonyl, cyclobutylaminocarbonyl, cyclopentylaminocarbonyl, dimethylphosphinoyl, diethylphosphinoyl, diisopropylphosphinoyl.

其中Z₁，Z₂，Z₃，Z₄，Z₅各自独立地选自：In some embodiments, R1 is selected from

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from:

(1) Hydrogen,

(2) C1-C6 alkyl,

(3) C1-C6 alkoxy,

(4) piperidinyl, N-methyl-4-piperidinyl, 4-N,N-dimethylaminopiperidinyl, 4-N,N-diethylaminopiperidinyl, 4-N, N-diisopropylaminopiperidinyl, 4-hydroxypiperidinyl

(5) 4-(4-Methylpiperazinyl)piperidinyl, 4-(4-ethylpiperazinyl)piperidinyl, 4-(4-isopropylpiperazinyl)piperidinyl, 4 -(4-Acetylpiperazinyl)piperidinyl, 4-(4-tert-butoxycarbonylpiperazinyl)piperidinyl, 4-(4-methanesulfonylpiperazinyl)piperidinyl, 4-( 4-(2-Hydroxyethyl)piperazinyl)piperidinyl, 4-(4-(2-cyanoethyl)piperazinyl)piperidinyl, 4-(4-(3-hydroxypropyl) Piperazinyl) piperidinyl, 4-(4-(2-N,N-dimethylaminoethyl)piperazinyl)piperidinyl, 4-(4-(2-N,N-diethyl) Aminoethyl)piperazinyl)piperidinyl, 4-(4-(3-N,N-dimethylaminopropyl)piperazinyl)piperidinyl, 4-(4-(3-N,N -Diethylaminopropyl)piperazinyl)piperidinyl, 4-(tetrahydropyrrolyl)piperidinyl, 4-(3-N,N-dimethylaminotetrahydropyrrolyl)piperidinyl,

(6) 4-methylpiperazinyl, 4-ethylpiperazinyl, 4-isopropylpiperazinyl, 4-acetylpiperazinyl, 4-tert-butoxycarbonylpiperazinyl, 4-methanesulfonic acid Acylpiperazinyl, 4-(2-hydroxyethyl)piperazinyl, 4-(2-cyanoethyl)piperazinyl, 4-(3-hydroxypropyl)piperazinyl, 4-(2- N,N-Dimethylaminoethyl)piperazinyl, 4-(2-N,N-diethylaminoethyl)piperazinyl, 4-(3-N,N-dimethylaminopropyl ) piperazinyl, 4-(3-N,N-diethylaminopropyl)piperazinyl, 4-(N-methyl-4-piperidinyl)piperazinyl, 4-(N-ethyl -4-Piperidinyl)piperazinyl or

(7) Z ₂ and Z ₃ or Z ₃ and Z ₄ form a nitrogen- or oxygen-containing substituted or unsubstituted five-membered ring, and the substituents can be selected from the same substituents as those of Z ₁ .

In some embodiments, R1 is selected from:

其中Z₁，Z₂，Z₃，Z₄，Z₅各自独立地选自：

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from:

(1) Hydrogen,

(2) methyl,

(3) Methoxy, isopropoxy,

(4) N-methyl-4-piperidinyl, 4-(4-methylpiperazinyl)piperidinyl, 4-(tetrahydropyrrol-1-yl)piperidinyl,

(5) 4-methylpiperazinyl, or

(6) Z ₂ and Z ₃ or Z ₃ and Z ₄ form

In some embodiments, R1 is selected from:

其中Z₂和Z₄二者之一为氢，另一为甲基，

One of Z ₂ and Z ₄ is hydrogen, the other is methyl,

One of Z ₁ and Z ₅ is hydrogen, and the other is selected from: methoxy, isopropoxy,

Z ₃ is selected from: N-methyl-4-piperidinyl, 4-methylpiperazinyl, 4-(4-methylpiperazinyl)piperidinyl, 4-(tetrahydropyrrol-1-yl) piperidinyl, or

Z ₂ and Z ₃ or Z ₃ and Z ₄ form

其中A₁，A₂，A₃，A₄，A₅各自独立地选自：In some embodiments, R2 is selected from

wherein A ₁ , A ₂ , A ₃ , A ₄ , A ₅ are each independently selected from:

(1) Hydrogen; (2) Methoxycarbonyl.

其中A₂和A₄二者之一为氢，另一为甲氧基羰基；A₁，A₃，A₅都为氢。In some embodiments, R2 is selected from:

One of A ₂ and A ₄ is hydrogen, and the other is methoxycarbonyl; A ₁ , A ₃ and A ₅ are all hydrogen.

In an eighth aspect, the present invention provides a compound represented by the following general formula IE, its stereoisomer, its prodrug, its pharmaceutically acceptable salt or its pharmaceutically acceptable solvate,

where R1 is selected from:

1) C1-C6 alkyl, 2-N,N-dimethylaminoethyl, 2-hydroxyethyl, 2-N,N-diethylaminoethyl, 2-N,N-diisopropyl Aminoethyl, 2-morpholinoethyl, 2-(4-methylpiperazinyl)ethyl, 3-N,N-dimethylaminopropyl, 3-N,N-diethylaminopropyl Base, 3-N,N-diisopropylaminopropyl, 3-morpholinylpropyl, 3-(4-methylpiperazinyl)propyl, C3-C6cycloalkyl, 4-N,N -Dimethylaminocyclohexyl, 4-N,N-diethylaminocyclohexyl, N-methyl-4-piperidinyl, N-ethyl-4-piperidinyl, N-isopropyl-4 -Piperidinyl, 1,3-dimethyl-5-pyrazolyl, 1-methyl-4-pyrazolyl, 3-methyl-5-isoxazolinyl, 1-(N-methyl -4-Piperidinyl)-4-pyrazolyl, 1-(N-tert-butoxycarbonyl-4-piperidinyl)-4-pyrazolyl;

其中Z₁，Z₂，Z₃，Z₄，Z₅各自独立地选自：2)

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from:

(1) hydrogen, fluorine, chlorine, bromine, iodine, nitro, cyano,

(2) C1-C6 alkyl, C1-C6 alkoxy, C1-C6 oxygen-containing alkyl, C1-C6 fluorine-containing alkyl, C1-C6 fluorine-containing alkoxy

(3) piperidinyl, N-methyl-4-piperidinyl, 4-N,N-dimethylaminopiperidinyl, 4-N,N-diethylaminopiperidinyl, 4-N, N-diisopropylaminopiperidinyl, 4-hydroxypiperidinyl, 4-(4-methylpiperazinyl)piperidinyl, 4-(4-ethylpiperazinyl)piperidinyl, 4- (4-Isopropylpiperazinyl)piperidinyl, 4-(4-acetylpiperazinyl)piperidinyl, 4-(4-tert-butoxycarbonylpiperazinyl)piperidinyl, 4-(4 -Methylsulfonylpiperazinyl)piperidyl, 4-(4-(2-hydroxyethyl)piperazinyl)piperidyl, 4-(4-(2-cyanoethyl)piperazinyl)piperidyl pyridyl, 4-(4-(3-hydroxypropyl)piperazinyl)piperidinyl, 4-(4-(2-N,N-dimethylaminoethyl)piperazinyl)piperidinyl, 4-(4-(2-N,N-Diethylaminoethyl)piperazinyl)piperidyl, 4-(4-(3-N,N-dimethylaminopropyl)piperazinyl) piperidinyl, 4-(4-(3-N,N-diethylaminopropyl)piperazinyl)piperidinyl, 4-(tetrahydropyrrolyl)piperidinyl, 4-(3-N, N-dimethylaminotetrahydropyrrolyl) piperidinyl,

(4) 4-methylpiperazinyl, 4-ethylpiperazinyl, 4-isopropylpiperazinyl, 4-acetylpiperazinyl, 4-tert-butoxycarbonylpiperazinyl, 4-methanesulfonic acid Acylpiperazinyl, 4-(2-hydroxyethyl)piperazinyl, 4-(2-cyanoethyl)piperazinyl, 4-(3-hydroxypropyl)piperazinyl, 4-(2- N,N-Dimethylaminoethyl)piperazinyl, 4-(2-N,N-diethylaminoethyl)piperazinyl, 4-(3-N,N-dimethylaminopropyl ) piperazinyl, 4-(3-N,N-diethylaminopropyl)piperazinyl, 4-(N-methyl-4-piperidinyl)piperazinyl, 4-(N-ethyl -4-Piperidinyl)piperazinyl,

(5) N,N-dimethylamino, N,N-diethylamino, N,N-diisopropylamino, 2-N,N-dimethylaminoethylamino, 2-morpholino Ethylamino, 2-(4-methylpiperazinyl)ethylamino, 3-N,N-dimethylaminopropylamino, 3-N,N-diethylaminopropylamino, 3-N ,N-diisopropylaminopropylamino, 3-morpholinopropylamino, 3-(4-methylpiperazinyl)propylamino, N-methylpiperidine-4-amino, N-ethyl piperidine-4-amino, N-isopropylpiperidine-4-amino,

(6) 2-N,N-dimethylaminoethoxy, 2-N,N-diethylaminoethoxy, 2-N,N-diisopropylaminoethoxy, 2-(4 -Methylpiperazinyl)ethoxy, 2-(4-acetylpiperazinyl)ethoxy, 2-morpholinylethoxy, 2-thiophenarinylethoxy, 2-piperidinyl Ethoxy, 3-N,N-dimethylaminopropoxy, 3-N,N-diethylaminopropoxy, 3-N,N-diisopropylaminopropoxy, 3-( 4-Methylpiperazinyl)propoxy, 3-(4-Acetylpiperazinyl)propoxy, 3-morpholinopropoxy, 3-thiophenarinylpropoxy, 3-piperidine pyridin-2-ylmethoxy, pyridin-3-ylmethoxy, pyridin-4-ylmethoxy, phenylmethoxy, monohalogen substituted phenylmethoxy, geminal dihalogen Substituted phenylmethoxy, heterodihalogen substituted phenylmethoxy,

(7) Hydroxysulfonyl, aminosulfonyl, methylaminosulfonyl, ethylaminosulfonyl, propylaminosulfonyl, isopropylaminosulfonyl, cyclopropylaminosulfonyl, cyclobutylaminosulfonyl, cyclopentylamino Sulfonyl, piperidin-1-ylsulfonyl, 4-hydroxypiperidin-1-ylsulfonyl, 4-N,N-dimethylaminopiperidin-1-ylsulfonyl, 4-N,N-di Ethylaminopiperidin-1-ylsulfonyl, tetrahydropyrrolyl-1-sulfonyl, 3-N,N-dimethylaminotetrahydropyrrolyl-1-sulfonyl, 3-N,N-diethyl ylaminotetrahydropyrrolyl-1-sulfonyl, 4-methylpiperazin-1-ylsulfonyl, 4-ethylpiperazinyl-1-sulfonyl, 4-acetylpiperazinyl-1-sulfonyl , 4-tert-butoxycarbonylpiperazinyl-1-sulfonyl, 4-(2-hydroxyethyl)piperazinyl-1-sulfonyl, 4-(2-cyanoethyl)piperazinyl-1- Sulfonyl, 4-(2-N,N-dimethylaminoethyl)piperazinyl-1-sulfonyl, 4-(2-N,N-diethylethyl)piperazinyl-1-sulfonyl Acyl, 4-(3-hydroxypropyl)piperazinyl-1-sulfonyl, 4-(3-N,N-dimethylaminopropyl)piperazinyl-1-sulfonyl, 4-(3- N,N-Diethylaminopropyl)piperazinyl-1-sulfonyl, morpholinyl-1-sulfonyl, 3,5-dimethylmorpholinyl-1-sulfonyl, 4-(4- Methyl-piperazin-1-yl)piperidin-1-ylsulfonyl, 4-(4-ethyl-1-piperazinyl)piperidin-1-ylsulfonyl, 4-(4-acetyl- 1-Piperazinyl)piperidin-1-ylsulfonyl, 4-(N-methyl-4-piperidinyl)piperazinyl-1-sulfonyl,

(8) Hydroxycarbonyl, aminocarbonyl, methylaminocarbonyl, ethylaminocarbonyl, propylaminocarbonyl, isopropylaminocarbonyl, cyclopropylaminocarbonyl, cyclobutylaminocarbonyl, cyclopentylaminocarbonyl, piperidinyl-1- Carbonyl, 4-hydroxypiperidinyl-1-carbonyl, 4-N,N-dimethylaminopiperidinyl-1-carbonyl, 4-N,N-diethylaminopiperidinyl-1-carbonyl, tetra Hydropyrrolyl-1-carbonyl, 3-N,N-dimethylaminotetrahydropyrrolyl-1-carbonyl, 3-N,N-diethylaminotetrahydropyrrolyl-1-carbonyl, 4-methyl Piperazin-1-ylcarbonyl, 4-ethylpiperazinyl-1-carbonyl, 4-acetylpiperazinyl-1-carbonyl, 4-tert-butoxycarbonylpiperazinyl-1-carbonyl, 4-(2 -Hydroxyethyl)piperazinyl-1-carbonyl, 4-(2-cyanoethyl)piperazinyl-1-carbonyl, 4-(2-N,N-dimethylaminoethyl)piperazinyl -1-carbonyl, 4-(2-N,N-diethylaminoethyl)piperazinyl-1-carbonyl, 4-(3-hydroxypropyl)piperazinyl-1-carbonyl, 4-(3 -N,N-Dimethylaminopropyl)piperazinyl-1-carbonyl, 4-(3-N,N-diethylaminopropyl)piperazinyl-1-carbonyl, morpholinyl-1- Carbonyl, 3,5-dimethylmorpholinyl-1-carbonyl, 4-(4-methyl-piperazin-1-yl)piperidin-1-ylcarbonyl, 4-(4-ethyl-1- Piperazinyl)piperidinyl-1-carbonyl, 4-(4-acetyl-1-piperazinyl)piperidinyl-1-carbonyl, 4-(N-methyl-4-piperidinyl)piperazine yl-1-carbonyl, methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, tert-butoxycarbonyl,

(9) carbamoylamino, methylcarbamoylamino, ethylcarbamoylamino, propylcarbamoylamino, isopropylcarbamoylamino, cyclopropylcarbamoylamino, cyclobutylcarbamoylamino, cyclo Amylcarbamoylamino, piperidinyl-1-carboxamido, 4-hydroxypiperidinyl-1-carboxamido, 4-N,N-dimethylaminopiperidinyl-1-carboxamido, 4-N,N-Diethylaminopiperidinyl-1-carboxamido, tetrahydropyrrolyl-1-carboxamido, 3-N,N-dimethylaminotetrahydropyrrolyl-1-carboxyl Amino, 3-N,N-diethylaminotetrahydropyrrolyl-1-carboxamido, 4-methylpiperazinyl-1-carboxamido, 4-ethylpiperazinyl-1-carboxamido , 4-Acetyl piperazinyl-1-carboxamido, 4-tert-butoxycarbonyl piperazinyl-1-carboxamido, 4-(2-hydroxyethyl) piperazinyl-1-carboxamido, 4-(2-cyanoethyl)piperazinyl-1-carboxamido, 4-(2-N,N-dimethylaminoethyl)piperazinyl-1-carboxamido, 4-(2 -N,N-Diethylaminoethyl)piperazinyl-1-carboxamido, 4-(3-hydroxypropyl)piperazinyl-1-carboxamido, 4-(3-N,N- Dimethylaminopropyl)piperazinyl-1-carboxamido, 4-(3-N,N-diethylaminopropyl)piperazinyl-1-carboxamido, morpholino-1-methyl amido, 3,5-dimethylmorpholino-1-carboxamido, 4-(4-methyl-piperazin-1-yl)piperidinyl-1-carboxamido, 4-(4- Ethyl-1-piperazinyl)piperidinyl-1-carboxamido, 4-(4-acetyl-1-piperazinyl)piperidinyl-1-carboxamido, 4-(N-methyl -4-Piperidinyl)piperazinyl-1-carboxamido;

其中A₁，A₂，A₃，A₄，A₅各自独立地选自：R2 is selected from

wherein A ₁ , A ₂ , A ₃ , A ₄ , A ₅ are each independently selected from:

(1) hydrogen, fluorine, chlorine, bromine, iodine, cyano, trifluoromethyl, trifluoromethoxy, nitro,

(2) Methylthio, ethylthio, methanesulfinyl, ethylsulfinyl, methanesulfonyl, ethanesulfonyl, methanesulfonylamino, methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, iso Propoxycarbonyl, n-butoxycarbonyl, methylaminocarbonyl, ethylaminocarbonyl, propylaminocarbonyl, cyclopropylaminocarbonyl, cyclobutylaminocarbonyl, cyclopentylaminocarbonyl, dimethylphosphinoyl.

In some embodiments, R1 is selected from:

其中Z₁，Z₂，Z₃，Z₄，Z₅各自独立地选自：

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from:

(1) Hydrogen,

(2) C1-C6 alkyl,

(3) C1-C6 alkoxy,

(4) piperidinyl, N-methyl-4-piperidinyl, 4-N,N-dimethylaminopiperidinyl, 4-N,N-diethylaminopiperidinyl, 4-N, N-diisopropylaminopiperidinyl, 4-hydroxypiperidinyl,

(5) 4-(4-Methylpiperazinyl)piperidinyl, 4-(4-ethylpiperazinyl)piperidinyl, 4-(4-isopropylpiperazinyl)piperidinyl, 4 -(4-Acetylpiperazinyl)piperidinyl, 4-(4-tert-butoxycarbonylpiperazinyl)piperidinyl, 4-(4-methanesulfonylpiperazinyl)piperidinyl, 4-( 4-(2-Hydroxyethyl)piperazinyl)piperidinyl, 4-(4-(2-cyanoethyl)piperazinyl)piperidinyl, 4-(4-(3-hydroxypropyl) Piperazinyl) piperidinyl, 4-(4-(2-N,N-dimethylaminoethyl)piperazinyl)piperidinyl, 4-(4-(2-N,N-diethyl) Aminoethyl)piperazinyl)piperidinyl, 4-(4-(3-N,N-dimethylaminopropyl)piperazinyl)piperidinyl, 4-(4-(3-N,N -Diethylaminopropyl)piperazinyl)piperidinyl, 4-(tetrahydropyrrolyl)piperidinyl, 4-(3-N,N-dimethylaminotetrahydropyrrolyl)piperidinyl,

(6) 4-methylpiperazinyl, 4-ethylpiperazinyl, 4-isopropylpiperazinyl, 4-acetylpiperazinyl, 4-tert-butoxycarbonylpiperazinyl, 4-methanesulfonic acid Acylpiperazinyl, 4-(2-hydroxyethyl)piperazinyl, 4-(2-cyanoethyl)piperazinyl, 4-(3-hydroxypropyl)piperazinyl, 4-(2- N,N-Dimethylaminoethyl)piperazinyl, 4-(2-N,N-diethylaminoethyl)piperazinyl, 4-(3-N,N-dimethylaminopropyl ) piperazinyl, 4-(3-N,N-diethylaminopropyl)piperazinyl, 4-(N-methyl-4-piperidinyl)piperazinyl, 4-(N-ethyl -4-Piperidinyl)piperazinyl.

其中Z₁，Z₂，Z₃，Z₄，Z₅各自独立地选自：In some embodiments, R1 is selected from

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from:

(1) Hydrogen,

(2) methyl, methoxy, ethoxy, isopropoxy,

(3) N-methyl-4-piperidinyl, 4-hydroxypiperidinyl, 4-(4-methylpiperazinyl)piperidinyl, 4-(tetrahydropyrrol-1-yl)piperidinyl ,

(4) 4-methylpiperazinyl.

In some embodiments, R1 is selected from:

其中Z₁和Z₅二者之一为氢，另一选自：甲氧基、乙氧基、异丙氧基；

Wherein one of Z ₁ and Z ₅ is hydrogen, and the other is selected from: methoxy, ethoxy, isopropoxy;

One of Z ₂ and Z ₄ is hydrogen, and the other is methyl;

Z ₃ is selected from: N-methyl-4-piperidinyl, 4-hydroxypiperidinyl, 4-methylpiperazinyl, 4-(4-methylpiperazinyl) piperidinyl, 4-(tetrakis Hydropyrrol-1-yl)piperidinyl.

其中A₁，A₂，A₃，A₄，A₅各自独立地选自：In some embodiments, R2 is selected from

wherein A ₁ , A ₂ , A ₃ , A ₄ , A ₅ are each independently selected from:

(1) Hydrogen, (2) Methoxycarbonyl.

其中A₁和A₅二者之一为氢，另一为甲氧基羰基；A₂，A₃，A₄都为氢。In some embodiments, R2 is selected from

One of A ₁ and A ₅ is hydrogen, and the other is methoxycarbonyl; A ₂ , A ₃ and A ₄ are all hydrogen.

In a ninth aspect, the present invention provides a compound represented by the following general formula IF, its stereoisomer, its prodrug, its pharmaceutically acceptable salt or its pharmaceutically acceptable solvate,

where R1 is selected from:

1) C1-C6 alkyl, 2-N,N-dimethylaminoethyl, 2-hydroxyethyl, 2-N,N-diethylaminoethyl, 2-N,N-diisopropyl Aminoethyl, 2-morpholinoethyl, 2-(4-methylpiperazinyl)ethyl, 3-N,N-dimethylaminopropyl, 3-N,N-diethylaminopropyl Base, 3-N,N-diisopropylaminopropyl, 3-morpholinylpropyl, 3-(4-methylpiperazinyl)propyl, C3-C6cycloalkyl, 4-N,N -Dimethylaminocyclohexyl, 4-N,N-diethylaminocyclohexyl, N-methyl-4-piperidinyl, N-ethyl-4-piperidinyl, N-isopropyl-4 -Piperidinyl, 1,3-dimethyl-5-pyrazolyl, 1-methyl-4-pyrazolyl, 3-methyl-5-isoxazolinyl, 1-(N-methyl -4-Piperidinyl)-4-pyrazolyl, 1-(N-tert-butoxycarbonyl-4-piperidinyl)-4-pyrazolyl;

其中Z₁，Z₂，Z₃，Z₄，Z₅各自独立地选自：2)

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from:

(1) hydrogen, fluorine, chlorine, bromine, iodine, nitro, cyano,

(2) C1-C6 alkyl, C1-C6 alkoxy, C1-C6 oxygen-containing alkyl, C1-C6 fluorine-containing alkyl, C1-C6 fluorine-containing alkoxy

(3) piperidinyl, N-methyl-4-piperidinyl, 4-N,N-dimethylaminopiperidinyl, 4-N,N-diethylaminopiperidinyl, 4-N, N-diisopropylaminopiperidinyl, 4-hydroxypiperidinyl, 4-(4-methylpiperazinyl)piperidinyl, 4-(N-ethylpiperazinyl)piperidinyl, 4- (4-Isopropylpiperazinyl)piperidinyl, 4-(4-acetylpiperazinyl)piperidinyl, 4-(4-tert-butoxycarbonylpiperazinyl)piperidinyl, 4-(4 -Methylsulfonylpiperazinyl)piperidyl, 4-(4-(2-hydroxyethyl)piperazinyl)piperidyl, 4-(4-(2-cyanoethyl)piperazinyl)piperidyl pyridyl, 4-(4-(3-hydroxypropyl)piperazinyl)piperidinyl, 4-(4-(2-N,N-dimethylaminoethyl)piperazinyl)piperidinyl, 4-(4-(2-N,N-Diethylaminoethyl)piperazinyl)piperidyl, 4-(4-(3-N,N-dimethylaminopropyl)piperazinyl) piperidinyl, 4-(4-(3-N,N-diethylaminopropyl)piperazinyl)piperidinyl, 4-(tetrahydropyrrolyl)piperidinyl, 4-(3-N, N-dimethylaminotetrahydropyrrolyl) piperidinyl,

(4) 4-methylpiperazinyl, 4-ethylpiperazinyl, 4-isopropylpiperazinyl, 4-acetylpiperazinyl, 4-tert-butoxycarbonylpiperazinyl, 4-methanesulfonic acid Acylpiperazinyl, 4-(2-hydroxyethyl)piperazinyl, 4-(2-cyanoethyl)piperazinyl, 4-(3-hydroxypropyl)piperazinyl, 4-(2- N,N-Dimethylaminoethyl)piperazinyl, 4-(2-N,N-diethylaminoethyl)piperazinyl, 4-(3-N,N-dimethylaminopropyl ) piperazinyl, 4-(3-N,N-diethylaminopropyl)piperazinyl, 4-(N-methyl-4-piperidinyl)piperazinyl, 4-(N-ethyl -4-Piperidinyl)piperazinyl,

(5) N,N-dimethylamino, N,N-diethylamino, N,N-diisopropylamino, 2-N,N-dimethylaminoethylamino, 2-morpholino Ethylamino, 2-(4-methylpiperazinyl)ethylamino, 3-N,N-dimethylaminopropylamino, 3-N,N-diethylaminopropylamino, 3-N ,N-diisopropylaminopropylamino, 3-morpholinopropylamino, 3-(4-methylpiperazinyl)propylamino, N-methylpiperidine-4-amino, N-ethyl piperidine-4-amino, N-isopropylpiperidine-4-amino,

(6) 2-N,N-dimethylaminoethoxy, 2-N,N-diethylaminoethoxy, 2-N,N-diisopropylaminoethoxy, 2-(4 -Methylpiperazinyl)ethoxy, 2-(4-acetylpiperazinyl)ethoxy, 2-morpholinylethoxy, 2-thiophenarinylethoxy, 2-piperidinyl Ethoxy, 3-N,N-dimethylaminopropoxy, 3-N,N-diethylaminopropoxy, 3-N,N-diisopropylaminopropoxy, 3-( 4-Methylpiperazinyl)propoxy, 3-(4-Acetylpiperazinyl)propoxy, 3-morpholinopropoxy, 3-thiophenarinylpropoxy, 3-piperidine pyridin-2-ylmethoxy, pyridin-3-ylmethoxy, pyridin-4-ylmethoxy, phenylmethoxy, monohalogen substituted phenylmethoxy, geminal dihalogen Substituted phenylmethoxy, heterodihalogen substituted phenylmethoxy,

(7) Hydroxysulfonyl, aminosulfonyl, methylaminosulfonyl, ethylaminosulfonyl, propylaminosulfonyl, isopropylaminosulfonyl, cyclopropylaminosulfonyl, cyclobutylaminosulfonyl, cyclopentylamino Sulfonyl, piperidin-1-ylsulfonyl, 4-hydroxypiperidin-1-ylsulfonyl, 4-N,N-dimethylaminopiperidin-1-ylsulfonyl, 4-N,N-di Ethylaminopiperidin-1-ylsulfonyl, tetrahydropyrrolyl-1-sulfonyl, 3-N,N-dimethylaminotetrahydropyrrolyl-1-sulfonyl, 3-N,N-diethyl ylaminotetrahydropyrrolyl-1-sulfonyl, 4-methylpiperazin-1-ylsulfonyl, 4-ethylpiperazinyl-1-sulfonyl, 4-acetylpiperazinyl-1-sulfonyl , 4-tert-butoxycarbonylpiperazinyl-1-sulfonyl, 4-(2-hydroxyethyl)piperazinyl-1-sulfonyl, 4-(2-cyanoethyl)piperazinyl-1- Sulfonyl, 4-(2-N,N-dimethylaminoethyl)piperazinyl-1-sulfonyl, 4-(2-N,N-diethylethyl)piperazinyl-1-sulfonyl Acyl, 4-(3-hydroxypropyl)piperazinyl-1-sulfonyl, 4-(3-N,N-dimethylaminopropyl)piperazinyl-1-sulfonyl, 4-(3- N,N-Diethylaminopropyl)piperazinyl-1-sulfonyl, morpholinyl-1-sulfonyl, 3,5-dimethylmorpholinyl-1-sulfonyl, 4-(4- Methyl-piperazin-1-yl)piperidin-1-ylsulfonyl, 4-(4-ethyl-1-piperazinyl)piperidin-1-ylsulfonyl, 4-(4-acetyl- 1-Piperazinyl)piperidin-1-ylsulfonyl, 4-(N-methyl-4-piperidinyl)piperazinyl-1-sulfonyl,

(8) Hydroxycarbonyl, aminocarbonyl, methylaminocarbonyl, ethylaminocarbonyl, propylaminocarbonyl, isopropylaminocarbonyl, cyclopropylaminocarbonyl, cyclobutylaminocarbonyl, cyclopentylaminocarbonyl, piperidinyl-1- Carbonyl, 4-hydroxypiperidinyl-1-carbonyl, 4-N,N-dimethylaminopiperidinyl-1-carbonyl, 4-N,N-diethylaminopiperidinyl-1-carbonyl, tetra Hydropyrrolyl-1-carbonyl, 3-N,N-dimethylaminotetrahydropyrrolyl-1-carbonyl, 3-N,N-diethylaminotetrahydropyrrolyl-1-carbonyl, 4-methyl Piperazin-1-ylcarbonyl, 4-ethylpiperazinyl-1-carbonyl, 4-acetylpiperazinyl-1-carbonyl, 4-tert-butoxycarbonylpiperazinyl-1-carbonyl, 4-(2 -Hydroxyethyl)piperazinyl-1-carbonyl, 4-(2-cyanoethyl)piperazinyl-1-carbonyl, 4-(2-N,N-dimethylaminoethyl)piperazinyl -1-carbonyl, 4-(2-N,N-diethylaminoethyl)piperazinyl-1-carbonyl, 4-(3-hydroxypropyl)piperazinyl-1-carbonyl, 4-(3 -N,N-Dimethylaminopropyl)piperazinyl-1-carbonyl, 4-(3-N,N-diethylaminopropyl)piperazinyl-1-carbonyl, morpholinyl-1- Carbonyl, 3,5-dimethylmorpholinyl-1-carbonyl, 4-(4-methyl-piperazin-1-yl)piperidin-1-ylcarbonyl, 4-(4-ethyl-1- Piperazinyl)piperidinyl-1-carbonyl, 4-(4-acetyl-1-piperazinyl)piperidinyl-1-carbonyl, 4-(N-methyl-4-piperidinyl)piperazine yl-1-carbonyl, methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, tert-butoxycarbonyl,

(9) carbamoylamino, methylcarbamoylamino, ethylcarbamoylamino, propylcarbamoylamino, isopropylcarbamoylamino, cyclopropylcarbamoylamino, cyclobutylcarbamoylamino, cyclo Amylcarbamoylamino, piperidinyl-1-carboxamido, 4-hydroxypiperidinyl-1-carboxamido, 4-N,N-dimethylaminopiperidinyl-1-carboxamido, 4-N,N-Diethylaminopiperidinyl-1-carboxamido, tetrahydropyrrolyl-1-carboxamido, 3-N,N-dimethylaminotetrahydropyrrolyl-1-carboxyl Amino, 3-N,N-diethylaminotetrahydropyrrolyl-1-carboxamido, 4-methylpiperazinyl-1-carboxamido, 4-ethylpiperazinyl-1-carboxamido , 4-Acetyl piperazinyl-1-carboxamido, 4-tert-butoxycarbonyl piperazinyl-1-carboxamido, 4-(2-hydroxyethyl) piperazinyl-1-carboxamido, 4-(2-cyanoethyl)piperazinyl-1-carboxamido, 4-(2-N,N-dimethylaminoethyl)piperazinyl-1-carboxamido, 4-(2 -N,N-Diethylaminoethyl)piperazinyl-1-carboxamido, 4-(3-hydroxypropyl)piperazinyl-1-carboxamido, 4-(3-N,N- Dimethylaminopropyl)piperazinyl-1-carboxamido, 4-(3-N,N-diethylaminopropyl)piperazinyl-1-carboxamido, morpholino-1-methyl amido, 3,5-dimethylmorpholino-1-carboxamido, 4-(4-methyl-piperazin-1-yl)piperidinyl-1-carboxamido, 4-(4- Ethyl-1-piperazinyl)piperidinyl-1-carboxamido, 4-(4-acetyl-1-piperazinyl)piperidinyl-1-carboxamido, 4-(N-methyl -4-Piperidinyl)piperazinyl-1-carboxamido; or

(10) Z ₂ and Z ₃ or Z ₃ and Z ₄ form a nitrogen- or oxygen-containing substituted or unsubstituted five-membered ring or six-membered ring, and the substituents can be selected from the same substituents as those of Z ₁ ;

其中A₁，A₂，A₃，A₄，A₅各自独立地选自：R2 is selected from

wherein A ₁ , A ₂ , A ₃ , A ₄ , A ₅ are each independently selected from:

(1) hydrogen, fluorine, chlorine, bromine, iodine, cyano, trifluoromethyl, trifluoromethoxy, nitro,

(2) methylthio, ethylthio, isopropylthio, methylsulfinyl, ethylsulfinyl, isopropylsulfinyl, methylsulfonyl, ethylsulfonyl, isopropylsulfonyl, methanesulfonylamino , methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, tert-butoxycarbonyl, methylaminocarbonyl, ethylaminocarbonyl, propylamino Carbonyl, isopropylaminocarbonyl, cyclopropylaminocarbonyl, cyclobutylaminocarbonyl, cyclopentylaminocarbonyl, dimethylphosphinoyl, diethylphosphinoyl, diisopropylphosphinoyl.

In some embodiments, R1 is selected from:

其中Z₁，Z₂，Z₃，Z₄，Z₅各自独立地选自：

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from:

(1) Hydrogen,

(2) C1-C6 alkoxy,

(3) 4-methylpiperazinyl, 4-ethylpiperazinyl, 4-isopropylpiperazinyl, 4-acetylpiperazinyl, 4-tert-butoxycarbonylpiperazinyl, 4-methanesulfonic acid Acylpiperazinyl, 4-(2-hydroxyethyl)piperazinyl, 4-(2-cyanoethyl)piperazinyl, 4-(3-hydroxypropyl)piperazinyl, 4-(2- N,N-Dimethylaminoethyl)piperazinyl, 4-(2-N,N-diethylaminoethyl)piperazinyl, 4-(3-N,N-dimethylaminopropyl ) piperazinyl, 4-(3-N,N-diethylaminopropyl)piperazinyl, 4-(N-methyl-4-piperidinyl)piperazinyl, 4-(N-ethyl -4-Piperidinyl)piperazinyl

(4) piperidinyl, N-methyl-4-piperidinyl, 4-N,N-dimethylaminopiperidinyl, 4-N,N-diethylaminopiperidinyl, 4-N, N-diisopropylaminopiperidinyl, 4-hydroxypiperidinyl, 4-(4-methylpiperazinyl)piperidinyl, 4-(4-ethylpiperazinyl)piperidinyl, 4- (4-Isopropylpiperazinyl)piperidinyl, 4-(4-acetylpiperazinyl)piperidinyl, 4-(4-tert-butoxycarbonylpiperazinyl)piperidinyl, 4-(4 -Methylsulfonylpiperazinyl)piperidyl, 4-(4-(2-hydroxyethyl)piperazinyl)piperidyl, 4-(4-(2-cyanoethyl)piperazinyl)piperidyl pyridyl, 4-(4-(3-hydroxypropyl)piperazinyl)piperidinyl, 4-(4-(2-N,N-dimethylaminoethyl)piperazinyl)piperidinyl, 4-(4-(2-N,N-Diethylaminoethyl)piperazinyl)piperidyl, 4-(4-(3-N,N-dimethylaminopropyl)piperazinyl) piperidinyl, 4-(4-(3-N,N-diethylaminopropyl)piperazinyl)piperidinyl, 4-(tetrahydropyrrol-1-yl)piperidinyl, 4-(3 -N,N-Dimethylaminotetrahydropyrrolyl)piperidinyl, or

(5) Z ₂ and Z ₃ or Z ₃ and Z ₄ form a nitrogen- or oxygen-containing substituted or unsubstituted five-membered ring, and the substituents can be selected from the same substituents as those of Z ₁ .

In some embodiments, R1 is selected from:

其中Z₁，Z₂，Z₃，Z₄，Z₅各自独立地选自：

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from:

(1) Hydrogen,

(2) Methoxy,

(3) 4-methylpiperazinyl,

(4) 4-(4-Methylpiperazinyl)piperidinyl, or

(5) Z ₂ and Z ₃ or Z ₃ and Z ₄ form

In some embodiments, R1 is selected from:

其中Z₁和Z₅二者之一为氢，另一为甲氧基；Z₄为氢；

Wherein one of Z ₁ and Z ₅ is hydrogen, the other is methoxy; Z ₄ is hydrogen;

Z ₃ is selected from: 4-methylpiperazinyl, 4-(4-methylpiperazinyl)piperidyl, or

Z ₂ forms with Z ₃

其中A₁，A₂，A₃，A₄，A₅各自独立地选自：In some embodiments, R2 is selected from

wherein A ₁ , A ₂ , A ₃ , A ₄ , A ₅ are each independently selected from:

(1) Hydrogen, (2) Fluorine, (3) Methylaminocarbonyl.

其中A₁和A₅二者之一为氢，另一为选自：氟，甲氨基羰基；且A₂和A₄二者之一为氢，另一为选自：氟，甲氨基羰基；A₃为氢。In some embodiments, R2 is selected from:

One of A ₁ and A ₅ is hydrogen, and the other is selected from: fluorine, methylaminocarbonyl; and one of A ₂ and A ₄ is hydrogen, and the other is selected from: fluorine, methylaminocarbonyl; A ₃ is hydrogen.

其中，A₁和A₅二者之一为氢，另一为甲氨基羰基；且A₂和A₄二者之一为氢，另一为氟；A₃为氢。In some embodiments, R2 is selected from:

Wherein, one of A ₁ and A ₅ is hydrogen, and the other is methylaminocarbonyl; and one of A ₂ and A ₄ is hydrogen, and the other is fluorine; A ₃ is hydrogen.

Tenth aspect, the present invention provides a compound represented by the following general formula IG, its stereoisomer, its prodrug, its pharmaceutically acceptable salt or its pharmaceutically acceptable solvate,

where R1 is selected from:

1) propylaminoethyl, 2-morpholinoethyl, 2-(4-methylpiperazinyl)ethyl, 3-N,N-dimethylaminopropyl, 3-N,N-di Ethylaminopropyl, 3-N,N-diisopropylaminopropyl, 3-morpholinylpropyl, 3-(4-methylpiperazinyl)propyl, C3-C6 cycloalkyl, 4 -N,N-Dimethylaminocyclohexyl, 4-N,N-diethylaminocyclohexyl, N-methyl-4-piperidinyl, N-ethyl-4-piperidinyl, N-iso Propyl-4-piperidinyl, 1,3-dimethyl-5-pyrazolyl, 1-methyl-4-pyrazolyl, 3-methyl-5-isoxazolinyl, 1-( N-methyl-4-piperidinyl)-4-pyrazolyl, 1-(N-tert-butoxycarbonyl-4-piperidinyl)-4-pyrazolyl;

其中Z₁，Z₂，Z₃，Z₄，Z₅各自独立地选自：2)

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from:

(1) hydrogen, fluorine, chlorine, bromine, iodine, nitro, cyano,

(2) C1-C6 alkyl, C1-C6 alkoxy, C1-C6 oxygen-containing alkyl, C1-C6 fluorine-containing alkyl, C1-C6 fluorine-containing alkoxy,

(3) piperidinyl, N-methyl-4-piperidinyl, 4-N,N-dimethylaminopiperidinyl, 4-N,N-diethylaminopiperidinyl, 4-N, N-diisopropylaminopiperidinyl, 4-hydroxypiperidinyl, 4-(4-methylpiperazinyl)piperidinyl, 4-(4-ethylpiperazinyl)piperidinyl, 4- (4-Isopropylpiperazinyl)piperidinyl, 4-(4-acetylpiperazinyl)piperidinyl, 4-(4-tert-butoxycarbonylpiperazinyl)piperidinyl, 4-(4 -Methylsulfonylpiperazinyl)piperidyl, 4-(4-(2-hydroxyethyl)piperazinyl)piperidyl, 4-(4-(2-cyanoethyl)piperazinyl)piperidyl pyridyl, 4-(4-(3-hydroxypropyl)piperazinyl)piperidinyl, 4-(4-(2-N,N-dimethylaminoethyl)piperazinyl)piperidinyl, 4-(4-(2-N,N-Diethylaminoethyl)piperazinyl)piperidyl, 4-(4-(3-N,N-dimethylaminopropyl)piperazinyl) piperidinyl, 4-(4-(3-N,N-diethylaminopropyl)piperazinyl)piperidinyl, 4-(tetrahydropyrrolyl)piperidinyl, 4-(3-N, N-dimethylaminotetrahydropyrrolyl) piperidinyl,

(4) 4-methylpiperazinyl, 4-ethylpiperazinyl, 4-isopropylpiperazinyl, 4-acetylpiperazinyl, 4-tert-butoxycarbonylpiperazinyl, 4-methanesulfonic acid Acylpiperazinyl, 4-(2-hydroxyethyl)piperazinyl, 4-(2-cyanoethyl)piperazinyl, 4-(3-hydroxypropyl)piperazinyl, 4-(2- N,N-Dimethylaminoethyl)piperazinyl, 4-(2-N,N-diethylaminoethyl)piperazinyl, 4-(3-N,N-dimethylaminopropyl ) piperazinyl, 4-(3-N,N-diethylaminopropyl)piperazinyl, 4-(N-methyl-4-piperidinyl)piperazinyl, 4-(N-ethyl -4-Piperidinyl)piperazinyl,

(5) N,N-dimethylamino, N,N-diethylamino, N,N-diisopropylamino, 2-N,N-dimethylaminoethylamino, 2-morpholino Ethylamino, 2-(4-methylpiperazinyl)ethylamino, 3-N,N-dimethylaminopropylamino, 3-N,N-diethylaminopropylamino, 3-N ,N-diisopropylaminopropylamino, 3-morpholinopropylamino, 3-(4-methylpiperazinyl)propylamino, N-methylpiperidine-4-amino, N-ethyl piperidine-4-amino, N-isopropylpiperidine-4-amino,

(6) 2-N,N-dimethylaminoethoxy, 2-N,N-diethylaminoethoxy, 2-N,N-diisopropylaminoethoxy, 2-(4 -Methylpiperazinyl)ethoxy, 2-(4-acetylpiperazinyl)ethoxy, 2-morpholinylethoxy, 2-thiophenarinylethoxy, 2-piperidinyl Ethoxy, 3-N,N-dimethylaminopropoxy, 3-N,N-diethylaminopropoxy, 3-N,N-diisopropylaminopropoxy, 3-( 4-Methylpiperazinyl)propoxy, 3-(4-Acetylpiperazinyl)propoxy, 3-morpholinopropoxy, 3-thiophenarinylpropoxy, 3-piperidine pyridin-2-ylmethoxy, pyridin-3-ylmethoxy, pyridin-4-ylmethoxy, phenylmethoxy, monohalogen substituted phenylmethoxy, geminal dihalogen Substituted phenylmethoxy, heterodihalogen substituted phenylmethoxy,

(7) Hydroxysulfonyl, aminosulfonyl, methylaminosulfonyl, ethylaminosulfonyl, propylaminosulfonyl, isopropylaminosulfonyl, cyclopropylaminosulfonyl, cyclobutylaminosulfonyl, cyclopentylamino Sulfonyl, piperidin-1-ylsulfonyl, 4-hydroxypiperidin-1-ylsulfonyl, 4-N,N-dimethylaminopiperidin-1-ylsulfonyl, 4-N,N-di Ethylaminopiperidin-1-ylsulfonyl, tetrahydropyrrolyl-1-sulfonyl, 3-N,N-dimethylaminotetrahydropyrrolyl-1-sulfonyl, 3-N,N-diethyl ylaminotetrahydropyrrolyl-1-sulfonyl, 4-methylpiperazin-1-ylsulfonyl, 4-ethylpiperazinyl-1-sulfonyl, 4-acetylpiperazinyl-1-sulfonyl , 4-tert-butoxycarbonylpiperazinyl-1-sulfonyl, 4-(2-hydroxyethyl)piperazinyl-1-sulfonyl, 4-(2-cyanoethyl)piperazinyl-1- Sulfonyl, 4-(2-N,N-dimethylaminoethyl)piperazinyl-1-sulfonyl, 4-(2-N,N-diethylethyl)piperazinyl-1-sulfonyl Acyl, 4-(3-hydroxypropyl)piperazinyl-1-sulfonyl, 4-(3-N,N-dimethylaminopropyl)piperazinyl-1-sulfonyl, 4-(3- N,N-Diethylaminopropyl)piperazinyl-1-sulfonyl, morpholinyl-1-sulfonyl, 3,5-dimethylmorpholinyl-1-sulfonyl, 4-(4- Methyl-piperazin-1-yl)piperidin-1-ylsulfonyl, 4-(4-ethyl-1-piperazinyl)piperidin-1-ylsulfonyl, 4-(4-acetyl- 1-Piperazinyl)piperidin-1-ylsulfonyl, 4-(N-methyl-4-piperidinyl)piperazinyl-1-sulfonyl,

(8) Hydroxycarbonyl, aminocarbonyl, methylaminocarbonyl, ethylaminocarbonyl, propylaminocarbonyl, isopropylaminocarbonyl, cyclopropylaminocarbonyl, cyclobutylaminocarbonyl, cyclopentylaminocarbonyl, piperidinyl-1- Carbonyl, 4-hydroxypiperidinyl-1-carbonyl, 4-N,N-dimethylaminopiperidinyl-1-carbonyl, 4-N,N-diethylaminopiperidinyl-1-carbonyl, tetra Hydropyrrolyl-1-carbonyl, 3-N,N-dimethylaminotetrahydropyrrolyl-1-carbonyl, 3-N,N-diethylaminotetrahydropyrrolyl-1-carbonyl, 4-methyl Piperazin-1-ylcarbonyl, 4-ethylpiperazinyl-1-carbonyl, 4-acetylpiperazinyl-1-carbonyl, 4-tert-butoxycarbonylpiperazinyl-1-carbonyl, 4-(2 -Hydroxyethyl)piperazinyl-1-carbonyl, 4-(2-cyanoethyl)piperazinyl-1-carbonyl, 4-(2-N,N-dimethylaminoethyl)piperazinyl -1-carbonyl, 4-(2-N,N-diethylaminoethyl)piperazinyl-1-carbonyl, 4-(3-hydroxypropyl)piperazinyl-1-carbonyl, 4-(3 -N,N-Dimethylaminopropyl)piperazinyl-1-carbonyl, 4-(3-N,N-diethylaminopropyl)piperazinyl-1-carbonyl, morpholinyl-1- Carbonyl, 3,5-dimethylmorpholinyl-1-carbonyl, 4-(4-methyl-piperazin-1-yl)piperidin-1-ylcarbonyl, 4-(4-ethyl-1- Piperazinyl)piperidinyl-1-carbonyl, 4-(4-acetyl-1-piperazinyl)piperidinyl-1-carbonyl, 4-(N-methyl-4-piperidinyl)piperazine yl-1-carbonyl, methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, tert-butoxycarbonyl,

(9) carbamoylamino, methylcarbamoylamino, ethylcarbamoylamino, propylcarbamoylamino, isopropylcarbamoylamino, cyclopropylcarbamoylamino, cyclobutylcarbamoylamino, cyclo Amylcarbamoylamino, piperidinyl-1-carboxamido, 4-hydroxypiperidinyl-1-carboxamido, 4-N,N-dimethylaminopiperidinyl-1-carboxamido, 4-N,N-Diethylaminopiperidinyl-1-carboxamido, tetrahydropyrrolyl-1-carboxamido, 3-N,N-dimethylaminotetrahydropyrrolyl-1-carboxyl Amino, 3-N,N-diethylaminotetrahydropyrrolyl-1-carboxamido, 4-methylpiperazinyl-1-carboxamido, 4-ethylpiperazinyl-1-carboxamido , 4-Acetyl piperazinyl-1-carboxamido, 4-tert-butoxycarbonyl piperazinyl-1-carboxamido, 4-(2-hydroxyethyl) piperazinyl-1-carboxamido, 4-(2-cyanoethyl)piperazinyl-1-carboxamido, 4-(2-N,N-dimethylaminoethyl)piperazinyl-1-carboxamido, 4-(2 -N,N-Diethylaminoethyl)piperazinyl-1-carboxamido, 4-(3-hydroxypropyl)piperazinyl-1-carboxamido, 4-(3-N,N- Dimethylaminopropyl)piperazinyl-1-carboxamido, 4-(3-N,N-diethylaminopropyl)piperazinyl-1-carboxamido, morpholino-1-methyl amido, 3,5-dimethylmorpholino-1-carboxamido, 4-(4-methyl-piperazin-1-yl)piperidinyl-1-carboxamido, 4-(4- Ethyl-1-piperazinyl)piperidinyl-1-carboxamido, 4-(4-acetyl-1-piperazinyl)piperidinyl-1-carboxamido, 4-(N-methyl -4-Piperidinyl)piperazinyl-1-carboxamido; or

(10) Z ₂ and Z ₃ or Z ₃ and Z ₄ form a nitrogen- or oxygen-containing substituted or unsubstituted five-membered ring or six-membered ring, and the substituents can be selected from the same substituents as Z ₁ ;

其中A₁，A₂，A₃，A₄，A₅各自独立地选自：R2 is selected from:

wherein A ₁ , A ₂ , A ₃ , A ₄ , A ₅ are each independently selected from:

(1) hydrogen, fluorine, chlorine, bromine, iodine, cyano, trifluoromethyl, trifluoromethoxy, nitro,

(2) Methylthio, ethylthio, methanesulfinyl, ethylsulfinyl, methanesulfonyl, ethanesulfonyl, methanesulfonylamino, methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, iso Propoxycarbonyl, n-butoxycarbonyl, methylaminocarbonyl, ethylaminocarbonyl, propylaminocarbonyl, cyclopropylaminocarbonyl, cyclobutylaminocarbonyl, cyclopentylaminocarbonyl, dimethylphosphinoyl.

In some embodiments, R1 is selected from:

其中Z₁，Z₂，Z₃，Z₄，Z₅各自独立地选自：

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from:

(1) Hydrogen,

(2) C1-C6 alkyl,

(3) C1-C6 alkoxy,

(4) piperidinyl, N-methyl-4-piperidinyl, 4-N,N-dimethylaminopiperidinyl, 4-N,N-diethylaminopiperidinyl, 4-N, N-diisopropylaminopiperidinyl, 4-hydroxypiperidinyl

(5) 4-(4-Methylpiperazinyl)piperidinyl, 4-(4-ethylpiperazinyl)piperidinyl, 4-(4-isopropylpiperazinyl)piperidinyl, 4 -(4-Acetylpiperazinyl)piperidinyl, 4-(4-tert-butoxycarbonylpiperazinyl)piperidinyl, 4-(4-methanesulfonylpiperazinyl)piperidinyl, 4-( 4-(2-Hydroxyethyl)piperazinyl)piperidinyl, 4-(4-(2-cyanoethyl)piperazinyl)piperidinyl, 4-(4-(3-hydroxypropyl) Piperazinyl) piperidinyl, 4-(4-(2-N,N-dimethylaminoethyl)piperazinyl)piperidinyl, 4-(4-(2-N,N-diethyl) Aminoethyl)piperazinyl)piperidinyl, 4-(4-(3-N,N-dimethylaminopropyl)piperazinyl)piperidinyl, 4-(4-(3-N,N -Diethylaminopropyl)piperazinyl)piperidinyl, 4-(tetrahydropyrrolyl)piperidinyl, 4-(3-N,N-dimethylaminotetrahydropyrrolyl)piperidinyl,

(6) 4-methylpiperazinyl, 4-ethylpiperazinyl, 4-isopropylpiperazinyl, 4-acetylpiperazinyl, 4-tert-butoxycarbonylpiperazinyl, 4-methanesulfonic acid Acylpiperazinyl, 4-(2-hydroxyethyl)piperazinyl, 4-(2-cyanoethyl)piperazinyl, 4-(3-hydroxypropyl)piperazinyl, 4-(2- N,N-Dimethylaminoethyl)piperazinyl, 4-(2-N,N-diethylaminoethyl)piperazinyl, 4-(3-N,N-dimethylaminopropyl ) piperazinyl, 4-(3-N,N-diethylaminopropyl)piperazinyl, 4-(N-methyl-4-piperidinyl)piperazinyl, 4-(N-ethyl -4-Piperidinyl)piperazinyl,

(7) Hydroxysulfonyl, aminosulfonyl, methylaminosulfonyl, ethylaminosulfonyl, propylaminosulfonyl, isopropylaminosulfonyl, cyclopropylaminosulfonyl, cyclobutylaminosulfonyl, cyclopentylamino Sulfonyl, piperidin-1-ylsulfonyl, 4-hydroxypiperidin-1-ylsulfonyl, 4-N,N-dimethylaminopiperidin-1-ylsulfonyl, 4-N,N-di Ethylaminopiperidin-1-ylsulfonyl, tetrahydropyrrolyl-1-sulfonyl, 3-N,N-dimethylaminotetrahydropyrrolyl-1-sulfonyl, 3-N,N-diethyl ylaminotetrahydropyrrolyl-1-sulfonyl, 4-methylpiperazin-1-ylsulfonyl, 4-ethylpiperazinyl-1-sulfonyl, 4-acetylpiperazinyl-1-sulfonyl , 4-tert-butoxycarbonylpiperazinyl-1-sulfonyl, 4-(2-hydroxyethyl)piperazinyl-1-sulfonyl, 4-(2-cyanoethyl)piperazinyl-1- Sulfonyl, 4-(2-N,N-dimethylaminoethyl)piperazinyl-1-sulfonyl, 4-(2-N,N-diethylethyl)piperazinyl-1-sulfonyl Acyl, 4-(3-hydroxypropyl)piperazinyl-1-sulfonyl, 4-(3-N,N-dimethylaminopropyl)piperazinyl-1-sulfonyl, 4-(3- N,N-Diethylaminopropyl)piperazinyl-1-sulfonyl, morpholinyl-1-sulfonyl, 3,5-dimethylmorpholinyl-1-sulfonyl, 4-(4- Methyl-piperazin-1-yl)piperidin-1-ylsulfonyl, 4-(4-ethyl-1-piperazinyl)piperidin-1-ylsulfonyl, 4-(4-acetyl- 1-Piperazinyl)piperidin-1-ylsulfonyl, 4-(N-methyl-4-piperidinyl)piperazinyl-1-sulfonyl, or

(8) Z ₂ and Z ₃ or Z ₃ and Z ₄ form a nitrogen- or oxygen-containing substituted or unsubstituted five-membered ring, and the substituents can be selected from the same substituents as those of Z ₁ .

In some embodiments, R1 is selected from:

其中Z₁，Z₂，Z₃，Z₄，Z₅各自独立地选自：

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from:

(1) Hydrogen,

(2) methyl, methoxy,

(3) N-methyl-4-piperidinyl, 4-hydroxypiperidinyl, 4-(4-methylpiperazinyl)piperidinyl, 4-(tetrahydropyrrol-1-yl)piperidinyl ,

(4) Sulfamoyl, or

(5) Z ₂ and Z ₃ or Z ₃ and Z ₄ form

In some embodiments, R1 is selected from:

其中Z₁和Z₅二者之一为氢，另一为甲氧基；

Wherein one of Z ₁ and Z ₅ is hydrogen, and the other is methoxy;

One of Z ₂ and Z ₄ is hydrogen, and the other is methyl;

Z ₃ is selected from: N-methyl-4-piperidinyl, 4-hydroxypiperidinyl, 4-(4-methylpiperazinyl)piperidinyl, 4-(tetrahydropyrrol-1-yl)piperidyl pyridyl, sulfamoyl, or

Z ₂ and Z ₃ or Z ₃ and Z ₄ form

其中A₁，A₂，A₃，A₄，A₅各自独立地选自：In some embodiments, R2 is selected from

wherein A ₁ , A ₂ , A ₃ , A ₄ , A ₅ are each independently selected from:

(1) Hydrogen, (2) Methanesulfonylamino.

其中A₂和A₄二者之一为氢，另一为甲磺酰氨基；A₁，A₃，A₅都为氢。In some embodiments, R2 is selected from:

One of A ₂ and A ₄ is hydrogen, the other is methanesulfonylamino; A ₁ , A ₃ and A ₅ are all hydrogen.

Eleventh aspect, the present invention provides a compound represented by the following general formula IH, its stereoisomer, its prodrug, its pharmaceutically acceptable salt or its pharmaceutically acceptable solvate,

where R1 is selected from:

1) Propylaminoethyl, 2-morpholinoethyl, 2-(4-4-methylpiperazinyl)ethyl, 3-N,N-dimethylaminopropyl, 3-N,N -Diethylaminopropyl, 3-N,N-diisopropylaminopropyl, 3-morpholinopropyl, 3-(4-methylpiperazinyl)propyl, C3-C6 cycloalkyl , 4-N,N-dimethylaminocyclohexyl, 4-N,N-diethylaminocyclohexyl, N-methyl-4-piperidinyl, N-ethyl-4-piperidinyl, N -Isopropyl-4-piperidinyl, 1,3-dimethyl-5-pyrazolyl, 1-methyl-4-pyrazolyl, 3-methyl-5-isoxazolinyl, 1 -(N-methyl-4-piperidinyl)-4-pyrazolyl, 1-(N-tert-butoxycarbonyl-4-piperidinyl)-4-pyrazolyl;

其中Z₁，Z₂，Z₃，Z₄，Z₅各自独立地选自：2)

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from:

(1) hydrogen, fluorine, chlorine, bromine, iodine, nitro, cyano,

(2) C1-C6 alkyl, C1-C6 alkoxy, C1-C6 oxygen-containing alkyl, C1-C6 fluorine-containing alkyl, C1-C6 fluorine-containing alkoxy,

(3) piperidinyl, N-methyl-4-piperidinyl, 4-N,N-dimethylaminopiperidinyl, 4-N,N-diethylaminopiperidinyl, 4-N, N-diisopropylaminopiperidinyl, 4-hydroxypiperidinyl, 4-(4-methylpiperazinyl)piperidinyl, 4-(4-ethylpiperazinyl)piperidinyl, 4- (4-Isopropylpiperazinyl)piperidinyl, 4-(4-acetylpiperazinyl)piperidinyl, 4-(4-tert-butoxycarbonylpiperazinyl)piperidinyl, 4-(4 -Methylsulfonylpiperazinyl)piperidyl, 4-(4-(2-hydroxyethyl)piperazinyl)piperidyl, 4-(4-(2-cyanoethyl)piperazinyl)piperidyl pyridyl, 4-(4-(3-hydroxypropyl)piperazinyl)piperidinyl, 4-(4-(2-N,N-dimethylaminoethyl)piperazinyl)piperidinyl, 4-(4-(2-N,N-Diethylaminoethyl)piperazinyl)piperidyl, 4-(4-(3-N,N-dimethylaminopropyl)piperazinyl) piperidinyl, 4-(4-(3-N,N-diethylaminopropyl)piperazinyl)piperidinyl, 4-(tetrahydropyrrolyl)piperidinyl, 4-(3-N, N-dimethylaminotetrahydropyrrolyl) piperidinyl,

(4) 4-methylpiperazinyl, 4-ethylpiperazinyl, 4-isopropylpiperazinyl, 4-acetylpiperazinyl, 4-tert-butoxycarbonylpiperazinyl, 4-methanesulfonic acid Acylpiperazinyl, 4-(2-hydroxyethyl)piperazinyl, 4-(2-cyanoethyl)piperazinyl, 4-(3-hydroxypropyl)piperazinyl, 4-(2- N,N-Dimethylaminoethyl)piperazinyl, 4-(2-N,N-diethylaminoethyl)piperazinyl, 4-(3-N,N-dimethylaminopropyl ) piperazinyl, 4-(3-N,N-diethylaminopropyl)piperazinyl, 4-(N-methyl-4-piperidinyl)piperazinyl, 4-(N-ethyl -4-Piperidinyl)piperazinyl,

(5) N,N-dimethylamino, N,N-diethylamino, N,N-diisopropylamino, 2-N,N-dimethylaminoethylamino, 2-morpholino Ethylamino, 2-(4-methylpiperazinyl)ethylamino, 3-N,N-dimethylaminopropylamino, 3-N,N-diethylaminopropylamino, 3-N ,N-diisopropylaminopropylamino, 3-morpholinopropylamino, 3-(4-methylpiperazinyl)propylamino, N-methylpiperidine-4-amino, N-ethyl piperidine-4-amino, N-isopropylpiperidine-4-amino,

(6) 2-N,N-dimethylaminoethoxy, 2-N,N-diethylaminoethoxy, 2-N,N-diisopropylaminoethoxy, 2-(4 -Methylpiperazinyl)ethoxy, 2-(4-acetylpiperazinyl)ethoxy, 2-morpholinylethoxy, 2-thiophenarinylethoxy, 2-piperidinyl Ethoxy, 3-N,N-dimethylaminopropoxy, 3-N,N-diethylaminopropoxy, 3-N,N-diisopropylaminopropoxy, 3-( 4-Methylpiperazinyl)propoxy, 3-(4-Acetylpiperazinyl)propoxy, 3-morpholinopropoxy, 3-thiophenarinylpropoxy, 3-piperidine pyridin-2-ylmethoxy, pyridin-3-ylmethoxy, pyridin-4-ylmethoxy, phenylmethoxy, monohalogen substituted phenylmethoxy, geminal dihalogen Substituted phenylmethoxy, heterodihalogen substituted phenylmethoxy,

(7) Hydroxysulfonyl, aminosulfonyl, methylaminosulfonyl, ethylaminosulfonyl, propylaminosulfonyl, isopropylaminosulfonyl, cyclopropylaminosulfonyl, cyclobutylaminosulfonyl, cyclopentylamino Sulfonyl, piperidin-1-ylsulfonyl, 4-hydroxypiperidin-1-ylsulfonyl, 4-N,N-dimethylaminopiperidin-1-ylsulfonyl, 4-N,N-di Ethylaminopiperidin-1-ylsulfonyl, tetrahydropyrrolyl-1-sulfonyl, 3-N,N-dimethylaminotetrahydropyrrolyl-1-sulfonyl, 3-N,N-diethyl ylaminotetrahydropyrrolyl-1-sulfonyl, 4-methylpiperazin-1-ylsulfonyl, 4-ethylpiperazinyl-1-sulfonyl, 4-acetylpiperazinyl-1-sulfonyl , 4-tert-butoxycarbonylpiperazinyl-1-sulfonyl, 4-(2-hydroxyethyl)piperazinyl-1-sulfonyl, 4-(2-cyanoethyl)piperazinyl-1- Sulfonyl, 4-(2-N,N-dimethylaminoethyl)piperazinyl-1-sulfonyl, 4-(2-N,N-diethylethyl)piperazinyl-1-sulfonyl Acyl, 4-(3-hydroxypropyl)piperazinyl-1-sulfonyl, 4-(3-N,N-dimethylaminopropyl)piperazinyl-1-sulfonyl, 4-(3- N,N-Diethylaminopropyl)piperazinyl-1-sulfonyl, morpholinyl-1-sulfonyl, 3,5-dimethylmorpholinyl-1-sulfonyl, 4-(4- Methyl-piperazin-1-yl)piperidin-1-ylsulfonyl, 4-(4-ethyl-1-piperazinyl)piperidin-1-ylsulfonyl, 4-(4-acetyl- 1-Piperazinyl)piperidin-1-ylsulfonyl, 4-(N-methyl-4-piperidinyl)piperazinyl-1-sulfonyl,

(8) Hydroxycarbonyl, aminocarbonyl, methylaminocarbonyl, ethylaminocarbonyl, propylaminocarbonyl, isopropylaminocarbonyl, cyclopropylaminocarbonyl, cyclobutylaminocarbonyl, cyclopentylaminocarbonyl, piperidinyl-1- Carbonyl, 4-hydroxypiperidinyl-1-carbonyl, 4-N,N-dimethylaminopiperidinyl-1-carbonyl, 4-N,N-diethylaminopiperidinyl-1-carbonyl, tetra Hydropyrrolyl-1-carbonyl, 3-N,N-dimethylaminotetrahydropyrrolyl-1-carbonyl, 3-N,N-diethylaminotetrahydropyrrolyl-1-carbonyl, 4-methyl Piperazin-1-ylcarbonyl, 4-ethylpiperazinyl-1-carbonyl, 4-acetylpiperazinyl-1-carbonyl, 4-tert-butoxycarbonylpiperazinyl-1-carbonyl, 4-(2 -Hydroxyethyl)piperazinyl-1-carbonyl, 4-(2-cyanoethyl)piperazinyl-1-carbonyl, 4-(2-N,N-dimethylaminoethyl)piperazinyl -1-carbonyl, 4-(2-N,N-diethylaminoethyl)piperazinyl-1-carbonyl, 4-(3-hydroxypropyl)piperazinyl-1-carbonyl, 4-(3 -N,N-Dimethylaminopropyl)piperazinyl-1-carbonyl, 4-(3-N,N-diethylaminopropyl)piperazinyl-1-carbonyl, morpholinyl-1- Carbonyl, 3,5-dimethylmorpholinyl-1-carbonyl, 4-(4-methyl-piperazin-1-yl)piperidin-1-ylcarbonyl, 4-(4-ethyl-1- Piperazinyl)piperidinyl-1-carbonyl, 4-(4-acetyl-1-piperazinyl)piperidinyl-1-carbonyl, 4-(N-methyl-4-piperidinyl)piperazine yl-1-carbonyl, methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, tert-butoxycarbonyl,

(9) carbamoylamino, methylcarbamoylamino, ethylcarbamoylamino, propylcarbamoylamino, isopropylcarbamoylamino, cyclopropylcarbamoylamino, cyclobutylcarbamoylamino, cyclo Amylcarbamoylamino, piperidinyl-1-carboxamido, 4-hydroxypiperidinyl-1-carboxamido, 4-N,N-dimethylaminopiperidinyl-1-carboxamido, 4-N,N-Diethylaminopiperidinyl-1-carboxamido, tetrahydropyrrolyl-1-carboxamido, 3-N,N-dimethylaminotetrahydropyrrolyl-1-carboxyl Amino, 3-N,N-diethylaminotetrahydropyrrolyl-1-carboxamido, 4-methylpiperazinyl-1-carboxamido, 4-ethylpiperazinyl-1-carboxamido , 4-Acetyl piperazinyl-1-carboxamido, 4-tert-butoxycarbonyl piperazinyl-1-carboxamido, 4-(2-hydroxyethyl) piperazinyl-1-carboxamido, 4-(2-cyanoethyl)piperazinyl-1-carboxamido, 4-(2-N,N-dimethylaminoethyl)piperazinyl-1-carboxamido, 4-(2 -N,N-Diethylaminoethyl)piperazinyl-1-carboxamido, 4-(3-hydroxypropyl)piperazinyl-1-carboxamido, 4-(3-N,N- Dimethylaminopropyl)piperazinyl-1-carboxamido, 4-(3-N,N-diethylaminopropyl)piperazinyl-1-carboxamido, morpholino-1-methyl amido, 3,5-dimethylmorpholino-1-carboxamido, 4-(4-methyl-piperazin-1-yl)piperidinyl-1-carboxamido, 4-(4- Ethyl-1-piperazinyl)piperidinyl-1-carboxamido, 4-(4-acetyl-1-piperazinyl)piperidinyl-1-carboxamido, 4-(N-methyl -4-Piperidinyl)piperazinyl-1-carboxamido; or

(10) Z ₂ and Z ₃ or Z ₃ and Z ₄ form a nitrogen- or oxygen-containing substituted or unsubstituted five-membered ring or six-membered ring, and the substituents can be selected from the same substituents as those of Z ₁ ;

其中A₁，A₂，A₃，A₄，A₅各自独立地选自：R2 is selected from: 2)

wherein A ₁ , A ₂ , A ₃ , A ₄ , A ₅ are each independently selected from:

(1) hydrogen, fluorine, chlorine, bromine, iodine, cyano, trifluoromethyl, trifluoromethoxy, nitro,

(2) Methylthio, ethylthio, methanesulfinyl, ethylsulfinyl, methanesulfonyl, ethanesulfonyl, methanesulfonylamino, methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, iso Propoxycarbonyl, n-butoxycarbonyl, methylaminocarbonyl, ethylaminocarbonyl, propylaminocarbonyl, cyclopropylaminocarbonyl, cyclobutylaminocarbonyl, cyclopentylaminocarbonyl, dimethylphosphinoyl.

In some embodiments, R1 is selected from:

其中Z₁，Z₂，Z₃，Z₄，Z₅各自独立地选自：

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from:

(1) Hydrogen,

(2) C1-C6 alkoxy,

(3) piperidinyl, N-methyl-4-piperidinyl, 4-N,N-dimethylaminopiperidinyl, 4-N,N-diethylaminopiperidinyl, 4-N, N-diisopropylaminopiperidinyl, 4-hydroxypiperidinyl

(4) 4-(4-Methylpiperazinyl)piperidinyl, 4-(4-ethylpiperazinyl)piperidinyl, 4-(4-isopropylpiperazinyl)piperidinyl, 4 -(4-Acetylpiperazinyl)piperidinyl, 4-(4-tert-butoxycarbonylpiperazinyl)piperidinyl, 4-(4-methanesulfonylpiperazinyl)piperidinyl, 4-( 4-(2-Hydroxyethyl)piperazinyl)piperidinyl, 4-(4-(2-cyanoethyl)piperazinyl)piperidinyl, 4-(4-(3-hydroxypropyl) Piperazinyl) piperidinyl, 4-(4-(2-N,N-dimethylaminoethyl)piperazinyl)piperidinyl, 4-(4-(2-N,N-diethyl) Aminoethyl)piperazinyl)piperidinyl, 4-(4-(3-N,N-dimethylaminopropyl)piperazinyl)piperidinyl, 4-(4-(3-N,N -Diethylaminopropyl)piperazinyl)piperidinyl, 4-(tetrahydropyrrolyl)piperidinyl, 4-(3-N,N-dimethylaminotetrahydropyrrolyl)piperidinyl,

(5) 4-methylpiperazinyl, 4-ethylpiperazinyl, 4-isopropylpiperazinyl, 4-acetylpiperazinyl, 4-tert-butoxycarbonylpiperazinyl, 4-methanesulfonic acid Acylpiperazinyl, 4-(2-hydroxyethyl)piperazinyl, 4-(2-cyanoethyl)piperazinyl, 4-(3-hydroxypropyl)piperazinyl, 4-(2- N,N-Dimethylaminoethyl)piperazinyl, 4-(2-N,N-diethylaminoethyl)piperazinyl, 4-(3-N,N-dimethylaminopropyl ) piperazinyl, 4-(3-N,N-diethylaminopropyl)piperazinyl, 4-(N-methyl-4-piperidinyl)piperazinyl, 4-(N-ethyl -4-Piperidinyl)piperazinyl,

(6) Hydroxysulfonyl, aminosulfonyl, methylaminosulfonyl, ethylaminosulfonyl, propylaminosulfonyl, isopropylaminosulfonyl, cyclopropylaminosulfonyl, cyclobutylaminosulfonyl, cyclopentylamino Sulfonyl, piperidin-1-ylsulfonyl, 4-hydroxypiperidin-1-ylsulfonyl, 4-N,N-dimethylaminopiperidin-1-ylsulfonyl, 4-N,N-di Ethylaminopiperidin-1-ylsulfonyl, tetrahydropyrrolyl-1-sulfonyl, 3-N,N-dimethylaminotetrahydropyrrolyl-1-sulfonyl, 3-N,N-diethyl ylaminotetrahydropyrrolyl-1-sulfonyl, 4-methylpiperazin-1-ylsulfonyl, 4-ethylpiperazinyl-1-sulfonyl, 4-acetylpiperazinyl-1-sulfonyl , 4-tert-butoxycarbonylpiperazinyl-1-sulfonyl, 4-(2-hydroxyethyl)piperazinyl-1-sulfonyl, 4-(2-cyanoethyl)piperazinyl-1- Sulfonyl, 4-(2-N,N-dimethylaminoethyl)piperazinyl-1-sulfonyl, 4-(2-N,N-diethylethyl)piperazinyl-1-sulfonyl Acyl, 4-(3-hydroxypropyl)piperazinyl-1-sulfonyl, 4-(3-N,N-dimethylaminopropyl)piperazinyl-1-sulfonyl, 4-(3- N,N-Diethylaminopropyl)piperazinyl-1-sulfonyl, morpholinyl-1-sulfonyl, 3,5-dimethylmorpholinyl-1-sulfonyl, 4-(4- Methyl-piperazin-1-yl)piperidin-1-ylsulfonyl, 4-(4-ethyl-1-piperazinyl)piperidin-1-ylsulfonyl, 4-(4-acetyl- 1-Piperazinyl)piperidin-1-ylsulfonyl, 4-(N-methyl-4-piperidinyl)piperazinyl-1-sulfonyl, or

(7) Z ₂ and Z ₃ or Z ₃ and Z ₄ form a nitrogen- or oxygen-containing substituted or unsubstituted five- or six-membered ring, and the substituents can be selected from the same substituents as those of Z ₁ .

In some embodiments, R1 is selected from:

其中Z₁，Z₂，Z₃，Z₄，Z₅各自独立地选自：

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from:

(1) Hydrogen,

(2) Methoxy,

(3) N-methyl-4-piperidinyl, 4-hydroxypiperidinyl, 4-(4-methylpiperazinyl)piperidinyl, 4-(tetrahydropyrrol-1-yl)piperidinyl ,

(4) 4-methylpiperazinyl,

(5) Sulfamoyl, or

(6) Z ₂ and Z ₃ or Z ₃ and Z ₄ form

In some embodiments, R1 is selected from:

其中Z₁和Z₅二者之一为氢，另一为甲氧基；Z₄为氢；

Wherein one of Z ₁ and Z ₅ is hydrogen, the other is methoxy; Z ₄ is hydrogen;

Z ₃ is selected from: N-methyl-4-piperidinyl, 4-hydroxypiperidinyl, 4-methylpiperazinyl, 4-(4-methylpiperazinyl) piperidinyl, 4-(tetrakis Hydropyrrol-1-yl)piperidinyl, aminosulfonyl, or

Z ₂ is formed with Z ₃

其中A₁，A₂，A₃，A₄，A₅各自独立地选自：In some embodiments, R2 is selected from:

wherein A ₁ , A ₂ , A ₃ , A ₄ , A ₅ are each independently selected from:

(1) Hydrogen,

(2) Methanesulfonamido.

其中A₁和A₅二者之一为氢，另一为甲磺酰氨基；A₂，A₃，A₄都为氢。In some embodiments, R2 is selected from:

One of A ₁ and A ₅ is hydrogen, and the other is methanesulfonylamino; A ₂ , A ₃ and A ₄ are all hydrogen.

In a twelfth aspect, the present invention provides a compound represented by the following general formula II, its stereoisomer, its prodrug, its pharmaceutically acceptable salt or its pharmaceutically acceptable solvate,

where R1 is selected from:

1) propylaminoethyl, 2-morpholinoethyl, 2-(4-methylpiperazinyl)ethyl, 3-N,N-dimethylaminopropyl, 3-N,N-di Ethylaminopropyl, 3-N,N-diisopropylaminopropyl, 3-morpholinylpropyl, 3-(4-methylpiperazinyl)propyl, C3-C6 cycloalkyl, 4 -N,N-Dimethylaminocyclohexyl, 4-N,N-diethylaminocyclohexyl, N-methyl-4-piperidinyl, N-ethyl-4-piperidinyl, N-iso Propyl-4-piperidinyl, 1,3-dimethyl-5-pyrazolyl, 1-methyl-4-pyrazolyl, 3-methyl-5-isoxazolinyl, 1-( N-methyl-4-piperidinyl)-4-pyrazolyl, 1-(N-tert-butoxycarbonyl-4-piperidinyl)-4-pyrazolyl;

其中Z₁，Z₂，Z₃，Z₄，Z₅各自独立地选自：2)

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from:

(1) hydrogen, fluorine, chlorine, bromine, iodine, nitro, cyano,

(2) C1-C6 alkyl, C1-C6 alkoxy, C1-C6 oxygen-containing alkyl, C1-C6 fluorine-containing alkyl, C1-C6 fluorine-containing alkoxy,

(3) piperidinyl, N-methyl-4-piperidinyl, 4-N,N-dimethylaminopiperidinyl, 4-N,N-diethylaminopiperidinyl, 4-N, N-diisopropylaminopiperidinyl, 4-hydroxypiperidinyl, 4-(4-methylpiperazinyl)piperidinyl, 4-(4-ethylpiperazinyl)piperidinyl, 4- (4-Isopropylpiperazinyl)piperidinyl, 4-(4-acetylpiperazinyl)piperidinyl, 4-(4-tert-butoxycarbonylpiperazinyl)piperidinyl, 4-(4 -Methylsulfonylpiperazinyl)piperidyl, 4-(4-(2-hydroxyethyl)piperazinyl)piperidyl, 4-(4-(2-cyanoethyl)piperazinyl)piperidyl pyridyl, 4-(4-(3-hydroxypropyl)piperazinyl)piperidinyl, 4-(4-(2-N,N-dimethylaminoethyl)piperazinyl)piperidinyl, 4-(4-(2-N,N-Diethylaminoethyl)piperazinyl)piperidyl, 4-(4-(3-N,N-dimethylaminopropyl)piperazinyl) piperidinyl, 4-(4-(3-N,N-diethylaminopropyl)piperazinyl)piperidinyl, 4-(tetrahydropyrrolyl)piperidinyl, 4-(3-N, N-dimethylaminotetrahydropyrrolyl) piperidinyl,

(4) 4-methylpiperazinyl, 4-ethylpiperazinyl, 4-isopropylpiperazinyl, 4-acetylpiperazinyl, 4-tert-butoxycarbonylpiperazinyl, 4-methanesulfonic acid Acylpiperazinyl, 4-(2-hydroxyethyl)piperazinyl, 4-(2-cyanoethyl)piperazinyl, 4-(3-hydroxypropyl)piperazinyl, 4-(2- N,N-Dimethylaminoethyl)piperazinyl, 4-(2-N,N-diethylaminoethyl)piperazinyl, 4-(3-N,N-dimethylaminopropyl ) piperazinyl, 4-(3-N,N-diethylaminopropyl)piperazinyl, 4-(N-methyl-4-piperidinyl)piperazinyl, 4-(N-ethyl -4-Piperidinyl)piperazinyl,

(5) N,N-dimethylamino, N,N-diethylamino, N,N-diisopropylamino, 2-N,N-dimethylaminoethylamino, 2-morpholino Ethylamino, 2-(4-methylpiperazinyl)ethylamino, 3-N,N-dimethylaminopropylamino, 3-N,N-diethylaminopropylamino, 3-N ,N-diisopropylaminopropylamino, 3-morpholinopropylamino, 3-(4-methylpiperazinyl)propylamino, N-methylpiperidine-4-amino, N-ethyl piperidine-4-amino, N-isopropylpiperidine-4-amino,

(6) 2-N,N-dimethylaminoethoxy, 2-N,N-diethylaminoethoxy, 2-N,N-diisopropylaminoethoxy, 2-(4 -Methylpiperazinyl)ethoxy, 2-(4-acetylpiperazinyl)ethoxy, 2-morpholinylethoxy, 2-thiophenarinylethoxy, 2-piperidinyl Ethoxy, 3-N,N-dimethylaminopropoxy, 3-N,N-diethylaminopropoxy, 3-N,N-diisopropylaminopropoxy, 3-( 4-Methylpiperazinyl)propoxy, 3-(4-Acetylpiperazinyl)propoxy, 3-morpholinopropoxy, 3-thiophenarinylpropoxy, 3-piperidine pyridin-2-ylmethoxy, pyridin-3-ylmethoxy, pyridin-4-ylmethoxy, phenylmethoxy, monohalogen substituted phenylmethoxy, geminal dihalogen Substituted phenylmethoxy, heterodihalogen substituted phenylmethoxy,

(7) Hydroxysulfonyl, aminosulfonyl, methylaminosulfonyl, ethylaminosulfonyl, propylaminosulfonyl, isopropylaminosulfonyl, cyclopropylaminosulfonyl, cyclobutylaminosulfonyl, cyclopentylamino Sulfonyl, piperidin-1-ylsulfonyl, 4-hydroxypiperidin-1-ylsulfonyl, 4-N,N-dimethylaminopiperidin-1-ylsulfonyl, 4-N,N-di Ethylaminopiperidin-1-ylsulfonyl, tetrahydropyrrolyl-1-sulfonyl, 3-N,N-dimethylaminotetrahydropyrrolyl-1-sulfonyl, 3-N,N-diethyl ylaminotetrahydropyrrolyl-1-sulfonyl, 4-methylpiperazin-1-ylsulfonyl, 4-ethylpiperazinyl-1-sulfonyl, 4-acetylpiperazinyl-1-sulfonyl , 4-tert-butoxycarbonylpiperazinyl-1-sulfonyl, 4-(2-hydroxyethyl)piperazinyl-1-sulfonyl, 4-(2-cyanoethyl)piperazinyl-1- Sulfonyl, 4-(2-N,N-dimethylaminoethyl)piperazinyl-1-sulfonyl, 4-(2-N,N-diethylethyl)piperazinyl-1-sulfonyl Acyl, 4-(3-hydroxypropyl)piperazinyl-1-sulfonyl, 4-(3-N,N-dimethylaminopropyl)piperazinyl-1-sulfonyl, 4-(3- N,N-Diethylaminopropyl)piperazinyl-1-sulfonyl, morpholinyl-1-sulfonyl, 3,5-dimethylmorpholinyl-1-sulfonyl, 4-(4- Methyl-piperazin-1-yl)piperidin-1-ylsulfonyl, 4-(4-ethyl-1-piperazinyl)piperidin-1-ylsulfonyl, 4-(4-acetyl- 1-Piperazinyl)piperidin-1-ylsulfonyl, 4-(N-methyl-4-piperidinyl)piperazinyl-1-sulfonyl,

(8) Hydroxycarbonyl, aminocarbonyl, methylaminocarbonyl, ethylaminocarbonyl, propylaminocarbonyl, isopropylaminocarbonyl, cyclopropylaminocarbonyl, cyclobutylaminocarbonyl, cyclopentylaminocarbonyl, piperidinyl-1- Carbonyl, 4-hydroxypiperidinyl-1-carbonyl, 4-N,N-dimethylaminopiperidinyl-1-carbonyl, 4-N,N-diethylaminopiperidinyl-1-carbonyl, tetra Hydropyrrolyl-1-carbonyl, 3-N,N-dimethylaminotetrahydropyrrolyl-1-carbonyl, 3-N,N-diethylaminotetrahydropyrrolyl-1-carbonyl, 4-methyl Piperazin-1-ylcarbonyl, 4-ethylpiperazinyl-1-carbonyl, 4-acetylpiperazinyl-1-carbonyl, 4-tert-butoxycarbonylpiperazinyl-1-carbonyl, 4-(2 -Hydroxyethyl)piperazinyl-1-carbonyl, 4-(2-cyanoethyl)piperazinyl-1-carbonyl, 4-(2-N,N-dimethylaminoethyl)piperazinyl -1-carbonyl, 4-(2-N,N-diethylaminoethyl)piperazinyl-1-carbonyl, 4-(3-hydroxypropyl)piperazinyl-1-carbonyl, 4-(3 -N,N-Dimethylaminopropyl)piperazinyl-1-carbonyl, 4-(3-N,N-diethylaminopropyl)piperazinyl-1-carbonyl, morpholinyl-1- Carbonyl, 3,5-dimethylmorpholinyl-1-carbonyl, 4-(4-methyl-piperazin-1-yl)piperidin-1-ylcarbonyl, 4-(4-ethyl-1- Piperazinyl)piperidinyl-1-carbonyl, 4-(4-acetyl-1-piperazinyl)piperidinyl-1-carbonyl, 4-(N-methyl-4-piperidinyl)piperazine yl-1-carbonyl, methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, tert-butoxycarbonyl,

(9) carbamoylamino, methylcarbamoylamino, ethylcarbamoylamino, propylcarbamoylamino, isopropylcarbamoylamino, cyclopropylcarbamoylamino, cyclobutylcarbamoylamino, cyclo Amylcarbamoylamino, piperidinyl-1-carboxamido, 4-hydroxypiperidinyl-1-carboxamido, 4-N,N-dimethylaminopiperidinyl-1-carboxamido, 4-N,N-Diethylaminopiperidinyl-1-carboxamido, tetrahydropyrrolyl-1-carboxamido, 3-N,N-dimethylaminotetrahydropyrrolyl-1-carboxyl Amino, 3-N,N-diethylaminotetrahydropyrrolyl-1-carboxamido, 4-methylpiperazinyl-1-carboxamido, 4-ethylpiperazinyl-1-carboxamido , 4-Acetyl piperazinyl-1-carboxamido, 4-tert-butoxycarbonyl piperazinyl-1-carboxamido, 4-(2-hydroxyethyl) piperazinyl-1-carboxamido, 4-(2-cyanoethyl)piperazinyl-1-carboxamido, 4-(2-N,N-dimethylaminoethyl)piperazinyl-1-carboxamido, 4-(2 -N,N-Diethylaminoethyl)piperazinyl-1-carboxamido, 4-(3-hydroxypropyl)piperazinyl-1-carboxamido, 4-(3-N,N- Dimethylaminopropyl)piperazinyl-1-carboxamido, 4-(3-N,N-diethylaminopropyl)piperazinyl-1-carboxamido, morpholino-1-methyl amido, 3,5-dimethylmorpholino-1-carboxamido, 4-(4-methyl-piperazin-1-yl)piperidinyl-1-carboxamido, 4-(4- Ethyl-1-piperazinyl)piperidinyl-1-carboxamido, 4-(4-acetyl-1-piperazinyl)piperidinyl-1-carboxamido, 4-(N-methyl -4-Piperidinyl)piperazinyl-1-carboxamido;

其中A₁，A₂，A₃，A₄，A₅各自独立地选自：R2 is selected from:

wherein A ₁ , A ₂ , A ₃ , A ₄ , A ₅ are each independently selected from:

(1) hydrogen, fluorine, chlorine, bromine, iodine, cyano, trifluoromethyl, trifluoromethoxy, nitro,

(2) methylthio, ethylthio, isopropylthio, methylsulfinyl, ethylsulfinyl, isopropylsulfinyl, methylsulfonyl, ethylsulfonyl, isopropylsulfonyl, methanesulfonylamino , methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, tert-butoxycarbonyl, methylaminocarbonyl, ethylaminocarbonyl, propylamino Carbonyl, isopropylaminocarbonyl, cyclopropylaminocarbonyl, cyclobutylaminocarbonyl, cyclopentylaminocarbonyl, dimethylphosphinoyl, diethylphosphinoyl, diisopropylphosphinoyl.

In some embodiments, R1 is selected from:

其中Z₁，Z₂，Z₃，Z₄，Z₅各自独立地选自：

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from:

(1) Hydrogen,

(2) C1-C6 alkyl,

(3) C1-C6 alkoxy,

(4) piperidinyl, N-methyl-4-piperidinyl, 4-N,N-dimethylaminopiperidinyl, 4-N,N-diethylaminopiperidinyl, 4-N, N-diisopropylaminopiperidinyl, 4-hydroxypiperidinyl

(5) 4-(4-Methylpiperazinyl)piperidinyl, 4-(4-ethylpiperazinyl)piperidinyl, 4-(4-isopropylpiperazinyl)piperidinyl, 4 -(4-Acetylpiperazinyl)piperidinyl, 4-(4-tert-butoxycarbonylpiperazinyl)piperidinyl, 4-(4-methanesulfonylpiperazinyl)piperidinyl, 4-( 4-(2-Hydroxyethyl)piperazinyl)piperidinyl, 4-(4-(2-cyanoethyl)piperazinyl)piperidinyl, 4-(4-(3-hydroxypropyl) Piperazinyl) piperidinyl, 4-(4-(2-N,N-dimethylaminoethyl)piperazinyl)piperidinyl, 4-(4-(2-N,N-diethyl) Aminoethyl)piperazinyl)piperidinyl, 4-(4-(3-N,N-dimethylaminopropyl)piperazinyl)piperidinyl, 4-(4-(3-N,N -Diethylaminopropyl)piperazinyl)piperidinyl, 4-(tetrahydropyrrolyl)piperidinyl, 4-(3-N,N-dimethylaminotetrahydropyrrolyl)piperidinyl,

(6) 4-methylpiperazinyl, 4-ethylpiperazinyl, 4-isopropylpiperazinyl, 4-acetylpiperazinyl, 4-tert-butoxycarbonylpiperazinyl, 4-methanesulfonic acid Acylpiperazinyl, 4-(2-hydroxyethyl)piperazinyl, 4-(2-cyanoethyl)piperazinyl, 4-(3-hydroxypropyl)piperazinyl, 4-(2- N,N-Dimethylaminoethyl)piperazinyl, 4-(2-N,N-diethylaminoethyl)piperazinyl, 4-(3-N,N-dimethylaminopropyl ) piperazinyl, 4-(3-N,N-diethylaminopropyl)piperazinyl, 4-(N-methyl-4-piperidinyl)piperazinyl, 4-(N-ethyl -4-Piperidinyl)piperazinyl.

In some embodiments, R1 is selected from:

其中Z₁，Z₂，Z₃，Z₄，Z₅各自独立地选自：

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from:

(1) Hydrogen,

(2) methyl, methoxy, ethoxy, isopropoxy;

(3) N-methyl-4-piperidinyl, 4-(4-methylpiperazinyl)piperidinyl, 4-(tetrahydropyrrol-1-yl)piperidinyl, 4-hydroxypiperidinyl ;

(4) 4-methylpiperazinyl.

In some embodiments, R1 is selected from:

其中Z₁和Z₅二者之一为氢，另一选自:甲氧基、乙氧基、异丙氧基；

Wherein one of Z ₁ and Z ₅ is hydrogen, and the other is selected from: methoxy, ethoxy, isopropoxy;

One of Z ₂ and Z ₄ is hydrogen, and the other is methyl;

Z ₃ is selected from: N-methyl-4-piperidinyl, 4-methylpiperazinyl, 4-hydroxypiperidinyl, 4-(4-methylpiperazinyl) piperidinyl, 4-(tetrakis Hydropyrrol-1-yl)piperidinyl.

其中A₁，A₂，A₃，A₄，A₅各自独立地选自：(1)氢；(2)甲氨基羰基。In some embodiments, R2 is selected from:

wherein A ₁ , A ₂ , A ₃ , A ₄ and A ₅ are each independently selected from: (1) hydrogen; (2) methylaminocarbonyl.

其中A₁和A₅二者之一为氢，另一为甲氨基羰基；A₂，A₃，A₄都为氢。In some embodiments, R2 is selected from

One of A ₁ and A ₅ is hydrogen, the other is methylaminocarbonyl; A ₂ , A ₃ and A ₄ are all hydrogen.

In a thirteenth aspect, the present invention provides a compound represented by the following general formula IPQ, its stereoisomer, its prodrug, its pharmaceutically acceptable salt or its pharmaceutically acceptable solvate,

where R1 is selected from:

1) C1-C6 alkyl, 2-N,N-dimethylaminoethyl, 2-hydroxyethyl, 2-N,N-diethylaminoethyl, 2-N,N-diisopropyl Aminoethyl, 2-morpholinoethyl, 2-(4-methylpiperazinyl)ethyl, 3-N,N-dimethylaminopropyl, 3-N,N-diethylaminopropyl Base, 3-N,N-diisopropylaminopropyl, 3-morpholinylpropyl, 3-(4-methylpiperazinyl)propyl, C3-C6cycloalkyl, 4-N,N -Dimethylaminocyclohexyl, 4-N,N-diethylaminocyclohexyl, N-methyl-4-piperidinyl, N-ethyl-4-piperidinyl, N-isopropyl-4 -Piperidinyl, 1,3-dimethyl-5-pyrazolyl, 1-methyl-4-pyrazolyl, 3-methyl-5-isoxazolinyl, 1-(N-methyl -4-Piperidinyl)-4-pyrazolyl, 1-(N-tert-butoxycarbonyl-4-piperidinyl)-4-pyrazolyl;

其中Z₁，Z₂，Z₃，Z₄，Z₅各自独立地选自：2)

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from:

(1) hydrogen, fluorine, chlorine, bromine, iodine, nitro, cyano,

(2) C1-C6 alkyl, C1-C6 alkoxy, C1-C6 oxygen-containing alkyl, C1-C6 fluorine-containing alkyl, C1-C6 fluorine-containing alkoxy,

(3) piperidinyl, N-methyl-4-piperidinyl, 4-dimethylaminopiperidinyl, 4-N,N-diethylaminopiperidinyl, 4-N,N-diiso propylaminopiperidinyl, 4-hydroxypiperidinyl, 4-(4-methylpiperazinyl)piperidinyl, 4-(4-ethylpiperazinyl)piperidinyl, 4-(4-iso Propylpiperazinyl)piperidinyl, 4-(4-acetylpiperazinyl)piperidinyl, 4-(4-tert-butoxycarbonylpiperazinyl)piperidinyl, 4-(4-methanesulfonyl Piperazinyl)piperidyl, 4-(4-(2-hydroxyethyl)piperazinyl)piperidinyl, 4-(4-(2-cyanoethyl)piperazinyl)piperidinyl, 4 -(4-(3-Hydroxypropyl)piperazinyl)piperidinyl, 4-(4-(2-N,N-dimethylaminoethyl)piperazinyl)piperidinyl, 4-(4 -(2-N,N-Diethylaminoethyl)piperazinyl)piperidinyl, 4-(4-(3-N,N-dimethylaminopropyl)piperazinyl)piperidinyl, 4-(4-(3-N,N-Diethylaminopropyl)piperazinyl)piperidinyl, 4-(tetrahydropyrrolyl)piperidinyl, 4-(3-N,N-dimethyl ylaminotetrahydropyrrolyl)piperidinyl,

(4) 4-methylpiperazinyl, 4-ethylpiperazinyl, 4-isopropylpiperazinyl, 4-acetylpiperazinyl, 4-tert-butoxycarbonylpiperazinyl, 4-methanesulfonic acid Acylpiperazinyl, 4-(2-hydroxyethyl)piperazinyl, 4-(2-cyanoethyl)piperazinyl, 4-(3-hydroxypropyl)piperazinyl, 4-(2- N,N-Dimethylaminoethyl)piperazinyl, 4-(2-N,N-diethylaminoethyl)piperazinyl, 4-(3-N,N-dimethylaminopropyl ) piperazinyl, 4-(3-N,N-diethylaminopropyl)piperazinyl, 4-(N-methyl-4-piperidinyl)piperazinyl, 4-(N-ethyl -4-Piperidinyl)piperazinyl,

(5) N,N-dimethylamino, N,N-diethylamino, N,N-diisopropylamino, 2-N,N-dimethylaminoethylamino, 2-morpholino Ethylamino, 2-(4-methylpiperazinyl)ethylamino, 3-N,N-dimethylaminopropylamino, 3-N,N-diethylaminopropylamino, 3-N ,N-diisopropylaminopropylamino, 3-morpholinopropylamino, 3-(4-methylpiperazinyl)propylamino, N-methylpiperidine-4-amino, N-ethyl piperidine-4-amino, N-isopropylpiperidine-4-amino,

(6) 2-N,N-dimethylaminoethoxy, 2-N,N-diethylaminoethoxy, 2-N,N-diisopropylaminoethoxy, 2-(4 -Methylpiperazinyl)ethoxy, 2-(4-acetylpiperazinyl)ethoxy, 2-morpholinylethoxy, 2-thiophenarinylethoxy, 2-piperidinyl Ethoxy, 3-N,N-dimethylaminopropoxy, 3-N,N-diethylaminopropoxy, 3-N,N-diisopropylaminopropoxy, 3-( 4-Methylpiperazinyl)propoxy, 3-(4-Acetylpiperazinyl)propoxy, 3-morpholinopropoxy, 3-thiophenarinylpropoxy, 3-piperidine pyridin-2-ylmethoxy, pyridin-3-ylmethoxy, pyridin-4-ylmethoxy, phenylmethoxy, monohalogen substituted phenylmethoxy, geminal dihalogen Substituted phenylmethoxy, heterodihalogen substituted phenylmethoxy,

(7) Hydroxysulfonyl, aminosulfonyl, methylaminosulfonyl, ethylaminosulfonyl, propylaminosulfonyl, isopropylaminosulfonyl, cyclopropylaminosulfonyl, cyclobutylaminosulfonyl, cyclopentylamino Sulfonyl, piperidin-1-ylsulfonyl, 4-hydroxypiperidin-1-ylsulfonyl, 4-N,N-dimethylaminopiperidin-1-ylsulfonyl, 4-N,N-di Ethylaminopiperidin-1-ylsulfonyl, tetrahydropyrrolyl-1-sulfonyl, 3-N,N-dimethylaminotetrahydropyrrolyl-1-sulfonyl, 3-N,N-diethyl ylaminotetrahydropyrrolyl-1-sulfonyl, 4-methylpiperazin-1-ylsulfonyl, 4-ethylpiperazinyl-1-sulfonyl, 4-acetylpiperazinyl-1-sulfonyl , 4-tert-butoxycarbonylpiperazinyl-1-sulfonyl, 4-(2-hydroxyethyl)piperazinyl-1-sulfonyl, 4-(2-cyanoethyl)piperazinyl-1- Sulfonyl, 4-(2-N,N-dimethylaminoethyl)piperazinyl-1-sulfonyl, 4-(2-N,N-diethylethyl)piperazinyl-1-sulfonyl Acyl, 4-(3-hydroxypropyl)piperazinyl-1-sulfonyl, 4-(3-N,N-dimethylaminopropyl)piperazinyl-1-sulfonyl, 4-(3- N,N-Diethylaminopropyl)piperazinyl-1-sulfonyl, morpholinyl-1-sulfonyl, 3,5-dimethylmorpholinyl-1-sulfonyl, 4-(4- Methyl-piperazin-1-yl)piperidin-1-ylsulfonyl, 4-(4-ethyl-1-piperazinyl)piperidin-1-ylsulfonyl, 4-(4-acetyl- 1-Piperazinyl)piperidin-1-ylsulfonyl, 4-(N-methyl-4-piperidinyl)piperazinyl-1-sulfonyl,

(8) Hydroxycarbonyl, aminocarbonyl, methylaminocarbonyl, ethylaminocarbonyl, propylaminocarbonyl, isopropylaminocarbonyl, cyclopropylaminocarbonyl, cyclobutylaminocarbonyl, cyclopentylaminocarbonyl, piperidinyl-1- Carbonyl, 4-hydroxypiperidinyl-1-carbonyl, 4-N,N-dimethylaminopiperidinyl-1-carbonyl, 4-N,N-diethylaminopiperidinyl-1-carbonyl, tetra Hydropyrrolyl-1-carbonyl, 3-N,N-dimethylaminotetrahydropyrrolyl-1-carbonyl, 3-N,N-diethylaminotetrahydropyrrolyl-1-carbonyl, 4-methyl Piperazin-1-ylcarbonyl, 4-ethylpiperazinyl-1-carbonyl, 4-acetylpiperazinyl-1-carbonyl, 4-tert-butoxycarbonylpiperazinyl-1-carbonyl, 4-(2 -Hydroxyethyl)piperazinyl-1-carbonyl, 4-(2-cyanoethyl)piperazinyl-1-carbonyl, 4-(2-N,N-dimethylaminoethyl)piperazinyl -1-carbonyl, 4-(2-N,N-diethylaminoethyl)piperazinyl-1-carbonyl, 4-(3-hydroxypropyl)piperazinyl-1-carbonyl, 4-(3 -N,N-Dimethylaminopropyl)piperazinyl-1-carbonyl, 4-(3-N,N-diethylaminopropyl)piperazinyl-1-carbonyl, morpholinyl-1- Carbonyl, 3,5-dimethylmorpholinyl-1-carbonyl, 4-(4-methyl-piperazin-1-yl)piperidin-1-ylcarbonyl, 4-(4-ethyl-1- Piperazinyl)piperidinyl-1-carbonyl, 4-(4-acetyl-1-piperazinyl)piperidinyl-1-carbonyl, 4-(N-methyl-4-piperidinyl)piperazine yl-1-carbonyl, methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, tert-butoxycarbonyl,

(9) carbamoylamino, methylcarbamoylamino, ethylcarbamoylamino, propylcarbamoylamino, isopropylcarbamoylamino, cyclopropylcarbamoylamino, cyclobutylcarbamoylamino, cyclo Amylcarbamoylamino, piperidinyl-1-carboxamido, 4-hydroxypiperidinyl-1-carboxamido, 4-N,N-dimethylaminopiperidinyl-1-carboxamido, 4-N,N-Diethylaminopiperidinyl-1-carboxamido, tetrahydropyrrolyl-1-carboxamido, 3-N,N-dimethylaminotetrahydropyrrolyl-1-carboxyl Amino, 3-N,N-diethylaminotetrahydropyrrolyl-1-carboxamido, 4-methylpiperazinyl-1-carboxamido, 4-ethylpiperazinyl-1-carboxamido , 4-Acetyl piperazinyl-1-carboxamido, 4-tert-butoxycarbonyl piperazinyl-1-carboxamido, 4-(2-hydroxyethyl) piperazinyl-1-carboxamido, 4-(2-cyanoethyl)piperazinyl-1-carboxamido, 4-(2-N,N-dimethylaminoethyl)piperazinyl-1-carboxamido, 4-(2 -N,N-Diethylaminoethyl)piperazinyl-1-carboxamido, 4-(3-hydroxypropyl)piperazinyl-1-carboxamido, 4-(3-N,N- Dimethylaminopropyl)piperazinyl-1-carboxamido, 4-(3-N,N-diethylaminopropyl)piperazinyl-1-carboxamido, morpholino-1-methyl amido, 3,5-dimethylmorpholino-1-carboxamido, 4-(4-methyl-piperazin-1-yl)piperidinyl-1-carboxamido, 4-(4- Ethyl-1-piperazinyl)piperidinyl-1-carboxamido, 4-(4-acetyl-1-piperazinyl)piperidinyl-1-carboxamido, 4-(N-methyl -4-Piperidinyl)piperazinyl-1-carboxamido; or

(10) Z ₂ and Z ₃ or Z ₃ and Z ₄ form a nitrogen- or oxygen-containing substituted or unsubstituted five-membered ring or six-membered ring, and the substituents can be selected from the same substituents as Z ₁ ;

其中A₁，A₂，A₃，A₄，A₅各自独立地选自：R2 is selected from

wherein A ₁ , A ₂ , A ₃ , A ₄ , A ₅ are each independently selected from:

(1) hydrogen, fluorine, chlorine, bromine, iodine, cyano, trifluoromethyl, trifluoromethoxy, nitro,

(2) Methylthio, ethylthio, isopropylthio, methylsulfinyl, ethylsulfinyl, isopropylsulfinyl, methylsulfonyl, ethylsulfonyl, isopropylsulfonyl, tert-butanesulfonyl , methanesulfonylamino, methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, tert-butoxycarbonyl, methylaminocarbonyl, ethyl Aminocarbonyl, propylaminocarbonyl, isopropylaminocarbonyl, dimethylaminocarbonyl, cyclopropylaminocarbonyl, cyclobutylaminocarbonyl, cyclopentylaminocarbonyl, dimethylphosphinoyl, diethylphosphinoyl, diethylaminocarbonyl Isopropylphosphinoyl.

其中Z₁，Z₂，Z₃，Z₄，Z₅各自独立地选自：In some embodiments, R1 is selected from

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from:

(1) Hydrogen,

(2) C1-C6 alkoxy,

(3) piperidinyl, N-methyl-4-piperidinyl, 4--dimethylaminopiperidinyl, 4-N,N-diethylaminopiperidinyl, 4-N,N-diethylaminopiperidinyl Isopropylaminopiperidinyl, 4-hydroxypiperidinyl, 4-(4-methylpiperazinyl)piperidinyl, 4-(4-ethylpiperazinyl)piperidinyl, 4-(4- Isopropylpiperazinyl)piperidinyl, 4-(4-acetylpiperazinyl)piperidinyl, 4-(4-tert-butoxycarbonylpiperazinyl)piperidinyl, 4-(4-methanesulfonyl) acylpiperazinyl)piperidyl, 4-(4-(2-hydroxyethyl)piperazinyl)piperidinyl, 4-(4-(2-cyanoethyl)piperazinyl)piperidinyl, 4-(4-(3-Hydroxypropyl)piperazinyl)piperidinyl, 4-(4-(2-N,N-dimethylaminoethyl)piperazinyl)piperidinyl, 4-( 4-(2-N,N-Diethylaminoethyl)piperazinyl)piperidinyl, 4-(4-(3-N,N-dimethylaminopropyl)piperazinyl)piperidinyl , 4-(4-(3-N,N-diethylaminopropyl)piperazinyl)piperidinyl, 4-(tetrahydropyrrolyl)piperidinyl, 4-(3-N,N-di Methylaminotetrahydropyrrolyl)piperidinyl,

(4) 4-methylpiperazinyl, 4-ethylpiperazinyl, 4-isopropylpiperazinyl, 4-acetylpiperazinyl, 4-tert-butoxycarbonylpiperazinyl, 4-methanesulfonic acid Acylpiperazinyl, 4-(2-hydroxyethyl)piperazinyl, 4-(2-cyanoethyl)piperazinyl, 4-(3-hydroxypropyl)piperazinyl, 4-(2- N,N-Dimethylaminoethyl)piperazinyl, 4-(2-N,N-diethylaminoethyl)piperazinyl, 4-(3-N,N-dimethylaminopropyl ) piperazinyl, 4-(3-N,N-diethylaminopropyl)piperazinyl, 4-(N-methyl-4-piperidinyl)piperazinyl, 4-(N-ethyl -4-Piperidinyl)piperazinyl or

(5) Z ₂ and Z ₃ or Z ₃ and Z ₄ form a nitrogen- or oxygen-containing substituted or unsubstituted five-membered ring, and the substituents may be selected from the same substituents as those of Z ₁ .

其中Z₁，Z₂，Z₃，Z₄，Z₅各自独立地任选自：In some embodiments, R1 is selected from:

Wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from:

(1) Hydrogen,

(2) C1-C6 alkoxy,

(3) 4-(4-Methylpiperazinyl)piperidinyl, 4-methylpiperazinyl, 4-dimethylamino-piperidinyl.

其中，In some embodiments, R1 is selected from:

in,

Z ₁ is methoxy, and Z ₃ is selected from: 4-dimethylamino-piperidinyl, 4-methylpiperazinyl, 4-(4-methylpiperazinyl)piperidinyl, and the rest are hydrogen; or

且Z₁为甲氧基，其余为氢。Z ₃ is formed with Z ₄

And Z ₁ is methoxy, and the rest are hydrogen.

其中A₁，A₂，A₃，A₄，A₅各自独立地任选自：In some embodiments, R2 is selected from:

Wherein A ₁ , A ₂ , A ₃ , A ₄ , A ₅ are each independently selected from:

(1) hydrogen, (2) isopropylaminocarbonyl, dimethylaminocarbonyl.

其中A₁和A₅二者之一为氢，另一为异丙氨基羰基或二甲氨基羰基；A₂，A₃，A₄都为氢。In some embodiments, R2 is selected from:

One of A ₁ and A ₅ is hydrogen, and the other is isopropylaminocarbonyl or dimethylaminocarbonyl; A ₂ , A ₃ and A ₄ are all hydrogen.

In a fourteenth aspect, the present invention provides a compound represented by the following general formula IJ, its stereoisomer, its prodrug, its pharmaceutically acceptable salt or its pharmaceutically acceptable solvate,

where R1 is selected from:

1) propylaminoethyl, 2-morpholinoethyl, 2-(4-methylpiperazinyl)ethyl, 3-N,N-dimethylaminopropyl, 3-N,N-di Ethylaminopropyl, 3-N,N-diisopropylaminopropyl, 3-morpholinylpropyl, 3-(4-methylpiperazinyl)propyl, C3-C6 cycloalkyl, 4 -N,N-Dimethylaminocyclohexyl, 4-N,N-diethylaminocyclohexyl, N-methyl-4-piperidinyl, N-ethyl-4-piperidinyl, N-iso Propyl-4-piperidinyl, 1,3-dimethyl-5-pyrazolyl, 1-methyl-4-pyrazolyl, 3-methyl-5-isoxazolinyl, 1-( N-methyl-4-piperidinyl)-4-pyrazolyl, 1-(N-tert-butoxycarbonyl-4-piperidinyl)-4-pyrazolyl;

其中Z₁，Z₂，Z₃，Z₄，Z₅各自独立地选自：2)

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from:

(1) hydrogen, fluorine, chlorine, bromine, iodine, nitro, cyano,

(2) C1-C6 alkyl, C1-C6 alkoxy, C1-C6 oxygen-containing alkyl, C1-C6 fluorine-containing alkyl, C1-C6 fluorine-containing alkoxy,

(3) piperidinyl, N-methyl-4-piperidinyl, 4-N,N-dimethylaminopiperidinyl, 4-N,N-diethylaminopiperidinyl, 4-N, N-diisopropylaminopiperidinyl, 4-hydroxypiperidinyl, 4-(4-methylpiperazinyl)piperidinyl, 4-(N-ethylpiperazinyl)piperidinyl, 4- (4-Isopropylpiperazinyl)piperidinyl, 4-(4-acetylpiperazinyl)piperidinyl, 4-(4-tert-butoxycarbonylpiperazinyl)piperidinyl, 4-(4 -Methylsulfonylpiperazinyl)piperidyl, 4-(4-(2-hydroxyethyl)piperazinyl)piperidyl, 4-(4-(2-cyanoethyl)piperazinyl)piperidyl pyridyl, 4-(4-(3-hydroxypropyl)piperazinyl)piperidinyl, 4-(4-(2-N,N-dimethylaminoethyl)piperazinyl)piperidinyl, 4-(4-(2-N,N-Diethylaminoethyl)piperazinyl)piperidyl, 4-(4-(3-N,N-dimethylaminopropyl)piperazinyl) piperidinyl, 4-(4-(3-N,N-diethylaminopropyl)piperazinyl)piperidinyl, 4-(tetrahydropyrrolyl)piperidinyl, 4-(3-N, N-dimethylaminotetrahydropyrrolyl) piperidinyl,

(4) 4-methylpiperazinyl, 4-ethylpiperazinyl, 4-isopropylpiperazinyl, 4-acetylpiperazinyl, 4-tert-butoxycarbonylpiperazinyl, 4-methanesulfonic acid Acylpiperazinyl, 4-(2-hydroxyethyl)piperazinyl, 4-(2-cyanoethyl)piperazinyl, 4-(3-hydroxypropyl)piperazinyl, 4-(2- N,N-Dimethylaminoethyl)piperazinyl, 4-(2-N,N-diethylaminoethyl)piperazinyl, 4-(3-N,N-dimethylaminopropyl ) piperazinyl, 4-(3-N,N-diethylaminopropyl)piperazinyl, 4-(N-methyl-4-piperidinyl)piperazinyl, 4-(N-ethyl -4-Piperidinyl)piperazinyl,

(5) N,N-dimethylamino, N,N-diethylamino, N,N-diisopropylamino, 2-N,N-dimethylaminoethylamino, 2-morpholino Ethylamino, 2-(4-methylpiperazinyl)ethylamino, 3-N,N-dimethylaminopropylamino, 3-N,N-diethylaminopropylamino, 3-N ,N-diisopropylaminopropylamino, 3-morpholinopropylamino, 3-(4-methylpiperazinyl)propylamino, N-methylpiperidine-4-amino, N-ethyl piperidine-4-amino, N-isopropylpiperidine-4-amino,

(6) 2-N,N-dimethylaminoethoxy, 2-N,N-diethylaminoethoxy, 2-N,N-diisopropylaminoethoxy, 2-(4 -Methylpiperazinyl)ethoxy, 2-(4-acetylpiperazinyl)ethoxy, 2-morpholinylethoxy, 2-thiophenarinylethoxy, 2-piperidinyl Ethoxy, 3-N,N-dimethylaminopropoxy, 3-N,N-diethylaminopropoxy, 3-N,N-diisopropylaminopropoxy, 3-( 4-Methylpiperazinyl)propoxy, 3-(4-Acetylpiperazinyl)propoxy, 3-morpholinopropoxy, 3-thiophenarinylpropoxy, 3-piperidine pyridin-2-ylmethoxy, pyridin-3-ylmethoxy, pyridin-4-ylmethoxy, phenylmethoxy, monohalogen substituted phenylmethoxy, geminal dihalogen Substituted phenylmethoxy, heterodihalogen substituted phenylmethoxy,

(7) Hydroxysulfonyl, aminosulfonyl, methylaminosulfonyl, ethylaminosulfonyl, propylaminosulfonyl, isopropylaminosulfonyl, cyclopropylaminosulfonyl, cyclobutylaminosulfonyl, cyclopentylamino Sulfonyl, piperidin-1-ylsulfonyl, 4-hydroxypiperidin-1-ylsulfonyl, 4-N,N-dimethylaminopiperidin-1-ylsulfonyl, 4-N,N-di Ethylaminopiperidin-1-ylsulfonyl, tetrahydropyrrolyl-1-sulfonyl, 3-N,N-dimethylaminotetrahydropyrrolyl-1-sulfonyl, 3-N,N-diethyl ylaminotetrahydropyrrolyl-1-sulfonyl, 4-methylpiperazin-1-ylsulfonyl, 4-ethylpiperazinyl-1-sulfonyl, 4-acetylpiperazinyl-1-sulfonyl , 4-tert-butoxycarbonylpiperazinyl-1-sulfonyl, 4-(2-hydroxyethyl)piperazinyl-1-sulfonyl, 4-(2-cyanoethyl)piperazinyl-1- Sulfonyl, 4-(2-N,N-dimethylaminoethyl)piperazinyl-1-sulfonyl, 4-(2-N,N-diethylethyl)piperazinyl-1-sulfonyl Acyl, 4-(3-hydroxypropyl)piperazinyl-1-sulfonyl, 4-(3-N,N-dimethylaminopropyl)piperazinyl-1-sulfonyl, 4-(3- N,N-Diethylaminopropyl)piperazinyl-1-sulfonyl, morpholinyl-1-sulfonyl, 3,5-dimethylmorpholinyl-1-sulfonyl, 4-(4- Methyl-piperazin-1-yl)piperidin-1-ylsulfonyl, 4-(4-ethyl-1-piperazinyl)piperidin-1-ylsulfonyl, 4-(4-acetyl- 1-Piperazinyl)piperidin-1-ylsulfonyl, 4-(N-methyl-4-piperidinyl)piperazinyl-1-sulfonyl,

(8) Hydroxycarbonyl, aminocarbonyl, methylaminocarbonyl, ethylaminocarbonyl, propylaminocarbonyl, isopropylaminocarbonyl, cyclopropylaminocarbonyl, cyclobutylaminocarbonyl, cyclopentylaminocarbonyl, piperidinyl-1- Carbonyl, 4-hydroxypiperidinyl-1-carbonyl, 4-N,N-dimethylaminopiperidinyl-1-carbonyl, 4-N,N-diethylaminopiperidinyl-1-carbonyl, tetra Hydropyrrolyl-1-carbonyl, 3-N,N-dimethylaminotetrahydropyrrolyl-1-carbonyl, 3-N,N-diethylaminotetrahydropyrrolyl-1-carbonyl, 4-methyl Piperazin-1-ylcarbonyl, 4-ethylpiperazinyl-1-carbonyl, 4-acetylpiperazinyl-1-carbonyl, 4-tert-butoxycarbonylpiperazinyl-1-carbonyl, 4-(2 -Hydroxyethyl)piperazinyl-1-carbonyl, 4-(2-cyanoethyl)piperazinyl-1-carbonyl, 4-(2-N,N-dimethylaminoethyl)piperazinyl -1-carbonyl, 4-(2-N,N-diethylaminoethyl)piperazinyl-1-carbonyl, 4-(3-hydroxypropyl)piperazinyl-1-carbonyl, 4-(3 -N,N-Dimethylaminopropyl)piperazinyl-1-carbonyl, 4-(3-N,N-diethylaminopropyl)piperazinyl-1-carbonyl, morpholinyl-1- Carbonyl, 3,5-dimethylmorpholinyl-1-carbonyl, 4-(4-methyl-piperazin-1-yl)piperidin-1-ylcarbonyl, 4-(4-ethyl-1- Piperazinyl)piperidinyl-1-carbonyl, 4-(4-acetyl-1-piperazinyl)piperidinyl-1-carbonyl, 4-(N-methyl-4-piperidinyl)piperazine yl-1-carbonyl, methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, tert-butoxycarbonyl,

(9) carbamoylamino, methylcarbamoylamino, ethylcarbamoylamino, propylcarbamoylamino, isopropylcarbamoylamino, cyclopropylcarbamoylamino, cyclobutylcarbamoylamino, cyclo Amylcarbamoylamino, piperidinyl-1-carboxamido, 4-hydroxypiperidinyl-1-carboxamido, 4-N,N-dimethylaminopiperidinyl-1-carboxamido, 4-N,N-Diethylaminopiperidinyl-1-carboxamido, tetrahydropyrrolyl-1-carboxamido, 3-N,N-dimethylaminotetrahydropyrrolyl-1-carboxyl Amino, 3-N,N-diethylaminotetrahydropyrrolyl-1-carboxamido, 4-methylpiperazinyl-1-carboxamido, 4-ethylpiperazinyl-1-carboxamido , 4-Acetyl piperazinyl-1-carboxamido, 4-tert-butoxycarbonyl piperazinyl-1-carboxamido, 4-(2-hydroxyethyl) piperazinyl-1-carboxamido, 4-(2-cyanoethyl)piperazinyl-1-carboxamido, 4-(2-N,N-dimethylaminoethyl)piperazinyl-1-carboxamido, 4-(2 -N,N-Diethylaminoethyl)piperazinyl-1-carboxamido, 4-(3-hydroxypropyl)piperazinyl-1-carboxamido, 4-(3-N,N- Dimethylaminopropyl)piperazinyl-1-carboxamido, 4-(3-N,N-diethylaminopropyl)piperazinyl-1-carboxamido, morpholino-1-methyl amido, 3,5-dimethylmorpholino-1-carboxamido, 4-(4-methyl-piperazin-1-yl)piperidinyl-1-carboxamido, 4-(4- Ethyl-1-piperazinyl)piperidinyl-1-carboxamido, 4-(4-acetyl-1-piperazinyl)piperidinyl-1-carboxamido, 4-(N-methyl -4-Piperidinyl)piperazinyl-1-carboxamido; or

(10) Z ₂ and Z ₃ or Z ₃ and Z ₄ form a nitrogen- or oxygen-containing substituted or unsubstituted five-membered ring or six-membered ring, and the substituents can be selected from the same substituents as Z ₁ ;

其中A₁，A₂，A₃，A₄，A₅各自独立地选自：R2 is selected from:

wherein A ₁ , A ₂ , A ₃ , A ₄ , A ₅ are each independently selected from:

(1) hydrogen, fluorine, chlorine, bromine, iodine, cyano, trifluoromethyl, trifluoromethoxy, nitro,

(2) methylthio, ethylthio, isopropylthio, methylsulfinyl, ethylsulfinyl, isopropylsulfinyl, methylsulfonyl, ethylsulfonyl, isopropylsulfonyl, methanesulfonylamino , methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, tert-butoxycarbonyl, methylaminocarbonyl, ethylaminocarbonyl, propylamino Carbonyl, isopropylaminocarbonyl, cyclopropylaminocarbonyl, cyclobutylaminocarbonyl, cyclopentylaminocarbonyl, dimethylphosphinoyl, diethylphosphinoyl, diisopropylphosphinoyl.

In some embodiments, R1 is selected from:

其中Z₁，Z₂，Z₃，Z₄，Z₅各自独立地选自：

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from:

(1) Hydrogen,

(2) C1-C6 alkyl,

(3) C1-C6 alkoxy,

(4) piperidinyl, N-methyl-4-piperidinyl, 4-N,N-dimethylaminopiperidinyl, 4-N,N-diethylaminopiperidinyl, 4-N, N-diisopropylaminopiperidinyl, 4-hydroxypiperidinyl,

(5) 4-(4-Methylpiperazinyl)piperidinyl, 4-(4-ethylpiperazinyl)piperidinyl, 4-(4-isopropylpiperazinyl)piperidinyl, 4 -(4-Acetylpiperazinyl)piperidinyl, 4-(4-tert-butoxycarbonylpiperazinyl)piperidinyl, 4-(4-methanesulfonylpiperazinyl)piperidinyl, 4-( 4-(2-Hydroxyethyl)piperazinyl)piperidinyl, 4-(4-(2-cyanoethyl)piperazinyl)piperidinyl, 4-(4-(3-hydroxypropyl) Piperazinyl) piperidinyl, 4-(4-(2-N,N-dimethylaminoethyl)piperazinyl)piperidinyl, 4-(4-(2-N,N-diethyl) Aminoethyl)piperazinyl)piperidinyl, 4-(4-(3-N,N-dimethylaminopropyl)piperazinyl)piperidinyl, 4-(4-(3-N,N -Diethylaminopropyl)piperazinyl)piperidinyl, 4-(tetrahydropyrrolyl)piperidinyl, 4-(3-N,N-dimethylaminotetrahydropyrrolyl)piperidinyl,

(6) 4-methylpiperazinyl, 4-ethylpiperazinyl, 4-isopropylpiperazinyl, 4-acetylpiperazinyl, 4-tert-butoxycarbonylpiperazinyl, 4-methanesulfonic acid Acylpiperazinyl, 4-(2-hydroxyethyl)piperazinyl, 4-(2-cyanoethyl)piperazinyl, 4-(3-hydroxypropyl)piperazinyl, 4-(2- N,N-Dimethylaminoethyl)piperazinyl, 4-(2-N,N-diethylaminoethyl)piperazinyl, 4-(3-N,N-dimethylaminopropyl ) piperazinyl, 4-(3-N,N-diethylaminopropyl)piperazinyl, 4-(N-methyl-4-piperidinyl)piperazinyl, 4-(N-ethyl -4-Piperidinyl)piperazinyl, or

(7) Z ₂ and Z ₃ or Z ₃ and Z ₄ form a nitrogen- or oxygen-containing substituted or unsubstituted five-membered ring, and the substituents can be selected from the same substituents as those of Z ₁ .

In some embodiments, R1 is selected from:

其中Z₁，Z₂，Z₃，Z₄，Z₅各自独立地选自：

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from:

(1) Hydrogen,

(2) methyl, methoxy,

(3) N-methyl-4-piperidinyl, 4-N,N-dimethylaminopiperidinyl, 4-(4-methylpiperazinyl)piperidinyl, 4-(tetrahydropyrrole- 1-yl) piperidinyl,

(4) 4-methylpiperazinyl, or

(5) Z ₂ and Z ₃ or Z ₃ and Z ₄ form

其中Z₁和Z₅二者之一为氢，另一为甲氧基，Z₂和Z₄二者之一为氢，另一为甲基，In some embodiments, R1 is selected from:

One of Z ₁ and Z ₅ is hydrogen, the other is methoxy, one of Z ₂ and Z ₄ is hydrogen, and the other is methyl,

Z ₃ is selected from: N-methyl-4-piperidinyl, 4-N,N-dimethylaminopiperidinyl, 4-methylpiperazinyl, 4-(4-methylpiperazinyl)piperidine pyridinyl, 4-(tetrahydropyrrol-1-yl)piperidinyl, or

Z ₂ and Z ₃ or Z ₃ and Z ₄ form

其中A₁，A₂，A₃，A₄，A₅各自独立地选自：In some embodiments, R2 is selected from:

wherein A ₁ , A ₂ , A ₃ , A ₄ , A ₅ are each independently selected from:

(1) hydrogen, (2) isopropylsulfinyl.

其中A₁和A₅二者之一为氢，另一为异丙亚磺酰基；A₂，A₃，A₄都为氢。In some embodiments, R2 is selected from:

One of A ₁ and A ₅ is hydrogen, and the other is isopropylsulfinyl; A ₂ , A ₃ and A ₄ are all hydrogen.

In a fifteenth aspect, the present invention provides a compound represented by the following general formula IK, its stereoisomer, its prodrug, its pharmaceutically acceptable salt or its pharmaceutically acceptable solvate,

where R1 is selected from:

1) C1-C6 alkyl, 2-N,N-dimethylaminoethyl, 2-hydroxyethyl, 2-N,N-diethylaminoethyl, 2-N,N-diisopropyl Aminoethyl, 2-morpholinoethyl, 2-(4-methylpiperazinyl)ethyl, 3-N,N-dimethylaminopropyl, 3-N,N-diethylaminopropyl Base, 3-N,N-diisopropylaminopropyl, 3-morpholinylpropyl, 3-(4-methylpiperazinyl)propyl, C3-C6cycloalkyl, 4-N,N -Dimethylaminocyclohexyl, 4-N,N-diethylaminocyclohexyl, N-methyl-4-piperidinyl, N-ethyl-4-piperidinyl, N-isopropyl-4 -Piperidinyl, 1,3-dimethyl-5-pyrazolyl, 1-methyl-4-pyrazolyl, 3-methyl-5-isoxazolinyl, 1-(N-methyl -4-Piperidinyl)-4-pyrazolyl, 1-(N-tert-butoxycarbonyl-4-piperidinyl)-4-pyrazolyl;

其中Z₁，Z₂，Z₃，Z₄，Z₅各自独立地选自：2)

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from:

(1) hydrogen, fluorine, chlorine, bromine, iodine, nitro, cyano,

(2) C1-C6 alkyl, C1-C6 alkoxy, C1-C6 oxygen-containing alkyl, C1-C6 fluorine-containing alkyl, C1-C6 fluorine-containing alkoxy,

(3) piperidinyl, N-methyl-4-piperidinyl, 4-N,N-dimethylaminopiperidinyl, 4-N,N-diethylaminopiperidinyl, 4-N, N-diisopropylaminopiperidinyl, 4-hydroxypiperidinyl, 4-(4-methylpiperazinyl)piperidinyl, 4-(4-ethylpiperazinyl)piperidinyl, 4- (4-Isopropylpiperazinyl)piperidinyl, 4-(4-acetylpiperazinyl)piperidinyl, 4-(4-tert-butoxycarbonylpiperazinyl)piperidinyl, 4-(4 -Methylsulfonylpiperazinyl)piperidyl, 4-(4-(2-hydroxyethyl)piperazinyl)piperidyl, 4-(4-(2-cyanoethyl)piperazinyl)piperidyl pyridyl, 4-(4-(3-hydroxypropyl)piperazinyl)piperidinyl, 4-(4-(2-N,N-dimethylaminoethyl)piperazinyl)piperidinyl, 4-(4-(2-N,N-Diethylaminoethyl)piperazinyl)piperidyl, 4-(4-(3-N,N-dimethylaminopropyl)piperazinyl) piperidinyl, 4-(4-(3-N,N-diethylaminopropyl)piperazinyl)piperidinyl, 4-(tetrahydropyrrolyl)piperidinyl, 4-(3-N, N-dimethylaminotetrahydropyrrolyl) piperidinyl,

(4) 4-methylpiperazinyl, 4-ethylpiperazinyl, 4-isopropylpiperazinyl, 4-acetylpiperazinyl, 4-tert-butoxycarbonylpiperazinyl, 4-methanesulfonic acid Acylpiperazinyl, 4-(2-hydroxyethyl)piperazinyl, 4-(2-cyanoethyl)piperazinyl, 4-(3-hydroxypropyl)piperazinyl, 4-(2- N,N-Dimethylaminoethyl)piperazinyl, 4-(2-N,N-diethylaminoethyl)piperazinyl, 4-(3-N,N-dimethylaminopropyl ) piperazinyl, 4-(3-N,N-diethylaminopropyl)piperazinyl, 4-(N-methyl-4-piperidinyl)piperazinyl, 4-(N-ethyl -4-Piperidinyl)piperazinyl,

(5) N,N-dimethylamino, N,N-diethylamino, N,N-diisopropylamino, 2-N,N-dimethylaminoethylamino, 2-morpholino Ethylamino, 2-(4-methylpiperazinyl)ethylamino, 3-N,N-dimethylaminopropylamino, 3-N,N-diethylaminopropylamino, 3-N ,N-diisopropylaminopropylamino, 3-morpholinopropylamino, 3-(4-methylpiperazinyl)propylamino, N-methylpiperidine-4-amino, N-ethyl piperidine-4-amino, N-isopropylpiperidine-4-amino,

(6) 2-N,N-dimethylaminoethoxy, 2-N,N-diethylaminoethoxy, 2-N,N-diisopropylaminoethoxy, 2-(4 -Methylpiperazinyl)ethoxy, 2-(4-acetylpiperazinyl)ethoxy, 2-morpholinylethoxy, 2-thiophenarinylethoxy, 2-piperidinyl Ethoxy, 3-N,N-dimethylaminopropoxy, 3-N,N-diethylaminopropoxy, 3-N,N-diisopropylaminopropoxy, 3-( 4-Methylpiperazinyl)propoxy, 3-(4-Acetylpiperazinyl)propoxy, 3-morpholinopropoxy, 3-thiophenarinylpropoxy, 3-piperidine pyridin-2-ylmethoxy, pyridin-3-ylmethoxy, pyridin-4-ylmethoxy, phenylmethoxy, monohalogen substituted phenylmethoxy, geminal dihalogen Substituted phenylmethoxy, heterodihalogen substituted phenylmethoxy,

(7) Hydroxysulfonyl, aminosulfonyl, methylaminosulfonyl, ethylaminosulfonyl, propylaminosulfonyl, isopropylaminosulfonyl, cyclopropylaminosulfonyl, cyclobutylaminosulfonyl, cyclopentylamino Sulfonyl, piperidin-1-ylsulfonyl, 4-hydroxypiperidin-1-ylsulfonyl, 4-N,N-dimethylaminopiperidin-1-ylsulfonyl, 4-N,N-di Ethylaminopiperidin-1-ylsulfonyl, tetrahydropyrrolyl-1-sulfonyl, 3-N,N-dimethylaminotetrahydropyrrolyl-1-sulfonyl, 3-N,N-diethyl ylaminotetrahydropyrrolyl-1-sulfonyl, 4-methylpiperazin-1-ylsulfonyl, 4-ethylpiperazinyl-1-sulfonyl, 4-acetylpiperazinyl-1-sulfonyl , 4-tert-butoxycarbonylpiperazinyl-1-sulfonyl, 4-(2-hydroxyethyl)piperazinyl-1-sulfonyl, 4-(2-cyanoethyl)piperazinyl-1- Sulfonyl, 4-(2-N,N-dimethylaminoethyl)piperazinyl-1-sulfonyl, 4-(2-N,N-diethylethyl)piperazinyl-1-sulfonyl Acyl, 4-(3-hydroxypropyl)piperazinyl-1-sulfonyl, 4-(3-N,N-dimethylaminopropyl)piperazinyl-1-sulfonyl, 4-(3- N,N-Diethylaminopropyl)piperazinyl-1-sulfonyl, morpholinyl-1-sulfonyl, 3,5-dimethylmorpholinyl-1-sulfonyl, 4-(4- Methyl-piperazin-1-yl)piperidin-1-ylsulfonyl, 4-(4-ethyl-1-piperazinyl)piperidin-1-ylsulfonyl, 4-(4-acetyl- 1-Piperazinyl)piperidin-1-ylsulfonyl, 4-(N-methyl-4-piperidinyl)piperazinyl-1-sulfonyl,

(8) Hydroxycarbonyl, aminocarbonyl, methylaminocarbonyl, ethylaminocarbonyl, propylaminocarbonyl, isopropylaminocarbonyl, cyclopropylaminocarbonyl, cyclobutylaminocarbonyl, cyclopentylaminocarbonyl, piperidinyl-1- Carbonyl, 4-hydroxypiperidinyl-1-carbonyl, 4-N,N-dimethylaminopiperidinyl-1-carbonyl, 4-N,N-diethylaminopiperidinyl-1-carbonyl, tetra Hydropyrrolyl-1-carbonyl, 3-N,N-dimethylaminotetrahydropyrrolyl-1-carbonyl, 3-N,N-diethylaminotetrahydropyrrolyl-1-carbonyl, 4-methyl Piperazin-1-ylcarbonyl, 4-ethylpiperazinyl-1-carbonyl, 4-acetylpiperazinyl-1-carbonyl, 4-tert-butoxycarbonylpiperazinyl-1-carbonyl, 4-(2 -Hydroxyethyl)piperazinyl-1-carbonyl, 4-(2-cyanoethyl)piperazinyl-1-carbonyl, 4-(2-N,N-dimethylaminoethyl)piperazinyl -1-carbonyl, 4-(2-N,N-diethylaminoethyl)piperazinyl-1-carbonyl, 4-(3-hydroxypropyl)piperazinyl-1-carbonyl, 4-(3 -N,N-Dimethylaminopropyl)piperazinyl-1-carbonyl, 4-(3-N,N-diethylaminopropyl)piperazinyl-1-carbonyl, morpholinyl-1- Carbonyl, 3,5-dimethylmorpholinyl-1-carbonyl, 4-(4-methyl-piperazin-1-yl)piperidin-1-ylcarbonyl, 4-(4-ethyl-1- Piperazinyl)piperidinyl-1-carbonyl, 4-(4-acetyl-1-piperazinyl)piperidinyl-1-carbonyl, 4-(N-methyl-4-piperidinyl)piperazine yl-1-carbonyl, methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, tert-butoxycarbonyl,

(9) carbamoylamino, methylcarbamoylamino, ethylcarbamoylamino, propylcarbamoylamino, isopropylcarbamoylamino, cyclopropylcarbamoylamino, cyclobutylcarbamoylamino, cyclo Amylcarbamoylamino, piperidinyl-1-carboxamido, 4-hydroxypiperidinyl-1-carboxamido, 4-N,N-dimethylaminopiperidinyl-1-carboxamido, 4-N,N-Diethylaminopiperidinyl-1-carboxamido, tetrahydropyrrolyl-1-carboxamido, 3-N,N-dimethylaminotetrahydropyrrolyl-1-carboxyl Amino, 3-N,N-diethylaminotetrahydropyrrolyl-1-carboxamido, 4-methylpiperazinyl-1-carboxamido, 4-ethylpiperazinyl-1-carboxamido , 4-Acetyl piperazinyl-1-carboxamido, 4-tert-butoxycarbonyl piperazinyl-1-carboxamido, 4-(2-hydroxyethyl) piperazinyl-1-carboxamido, 4-(2-cyanoethyl)piperazinyl-1-carboxamido, 4-(2-N,N-dimethylaminoethyl)piperazinyl-1-carboxamido, 4-(2 -N,N-Diethylaminoethyl)piperazinyl-1-carboxamido, 4-(3-hydroxypropyl)piperazinyl-1-carboxamido, 4-(3-N,N- Dimethylaminopropyl)piperazinyl-1-carboxamido, 4-(3-N,N-diethylaminopropyl)piperazinyl-1-carboxamido, morpholino-1-methyl amido, 3,5-dimethylmorpholino-1-carboxamido, 4-(4-methyl-piperazin-1-yl)piperidinyl-1-carboxamido, 4-(4- Ethyl-1-piperazinyl)piperidinyl-1-carboxamido, 4-(4-acetyl-1-piperazinyl)piperidinyl-1-carboxamido, 4-(N-methyl -4-Piperidinyl)piperazinyl-1-carboxamido; or

(10) Z ₂ and Z ₃ or Z ₃ and Z ₄ form a nitrogen- or oxygen-containing substituted or unsubstituted five-membered ring or six-membered ring, and the substituents can be selected from the same substituents as Z ₁ ;

其中A₁，A₂，A₃，A₄，A₅各自独立地选自：R2 is selected from:

wherein A ₁ , A ₂ , A ₃ , A ₄ , A ₅ are each independently selected from:

(1) hydrogen, fluorine, chlorine, bromine, iodine, cyano, trifluoromethyl, trifluoromethoxy, nitro,

(2) methylthio, ethylthio, isopropylthio, methylsulfinyl, ethylsulfinyl, isopropylsulfinyl, methylsulfonyl, ethylsulfonyl, isopropylsulfonyl, methanesulfonylamino , methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, tert-butoxycarbonyl, methylaminocarbonyl, ethylaminocarbonyl, propylamino Carbonyl, isopropylaminocarbonyl, cyclopropylaminocarbonyl, cyclobutylaminocarbonyl, cyclopentylaminocarbonyl, dimethylphosphinoyl, diethylphosphinoyl, diisopropylphosphinoyl.

In some embodiments, R1 is selected from:

其中Z₁，Z₂，Z₃，Z₄，Z₅各自独立地选自：

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from:

(1) Hydrogen,

(2) C1-C6 alkyl,

(3) C1-C6 alkoxy

(4) piperidinyl, N-methyl-4-piperidinyl, 4-N,N-dimethylaminopiperidinyl, 4-N,N-diethylaminopiperidinyl, 4-N, N-diisopropylaminopiperidinyl, 4-hydroxypiperidinyl

(5) 4-(4-Methylpiperazinyl)piperidinyl, 4-(4-ethylpiperazinyl)piperidinyl, 4-(4-isopropylpiperazinyl)piperidinyl, 4 -(4-Acetylpiperazinyl)piperidinyl, 4-(4-tert-butoxycarbonylpiperazinyl)piperidinyl, 4-(4-methanesulfonylpiperazinyl)piperidinyl, 4-( 4-(2-Hydroxyethyl)piperazinyl)piperidinyl, 4-(4-(2-cyanoethyl)piperazinyl)piperidinyl, 4-(4-(3-hydroxypropyl) Piperazinyl) piperidinyl, 4-(4-(2-N,N-dimethylaminoethyl)piperazinyl)piperidinyl, 4-(4-(2-N,N-diethyl) Aminoethyl)piperazinyl)piperidinyl, 4-(4-(3-N,N-dimethylaminopropyl)piperazinyl)piperidinyl, 4-(4-(3-N,N -Diethylaminopropyl)piperazinyl)piperidinyl, 4-(tetrahydropyrrolyl)piperidinyl, 4-(3-N,N-dimethylaminotetrahydropyrrolyl)piperidinyl,

(6) 4-methylpiperazinyl, 4-ethylpiperazinyl, 4-isopropylpiperazinyl, 4-acetylpiperazinyl, 4-tert-butoxycarbonylpiperazinyl, 4-methanesulfonic acid Acylpiperazinyl, 4-(2-hydroxyethyl)piperazinyl, 4-(2-cyanoethyl)piperazinyl, 4-(3-hydroxypropyl)piperazinyl, 4-(2- N,N-Dimethylaminoethyl)piperazinyl, 4-(2-N,N-diethylaminoethyl)piperazinyl, 4-(3-N,N-dimethylaminopropyl ) piperazinyl, 4-(3-N,N-diethylaminopropyl)piperazinyl, 4-(N-methyl-4-piperidinyl)piperazinyl, 4-(N-ethyl -4-Piperidinyl)piperazinyl, or

(7) Z ₂ and Z ₃ or Z ₃ and Z ₄ form a nitrogen- or oxygen-containing substituted or unsubstituted five-membered or six-membered ring, and the substituents can be selected from the same substituents as those of Z ₁ .

In some embodiments, R1 is selected from:

其中Z₁，Z₂，Z₃，Z₄，Z₅各自独立地选自：

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from:

(1) Hydrogen,

(2) methyl, methoxy,

(3) 4-methylpiperazinyl,

(4) N-methyl-4-piperidinyl, 4-(4-methylpiperazinyl)piperidinyl, 4-(tetrahydropyrrol-1-yl)piperidinyl, 4-N,N- Dimethylaminopiperidinyl, or

(5) Z ₂ and Z ₃ or Z ₃ and Z ₄ form

其中Z₂和Z₄二者之一为氢，另一为甲基，Z₁和Z₅二者之一为氢，另一为甲氧基，In some embodiments, R1 is selected from

Wherein one of Z ₂ and Z ₄ is hydrogen, the other is methyl, one of Z ₁ and Z ₅ is hydrogen, and the other is methoxy,

Z ₃ is selected from: N-methyl-4-piperidinyl, 4-methylpiperazinyl, 4-(4-methylpiperazinyl)piperidinyl, 4-(tetrahydropyrrol-1-yl) piperidinyl, 4-N,N-dimethylaminopiperidinyl, or

Z ₂ and Z ₃ or Z ₃ and Z ₄ form

其中A₁，A₂，A₃，A₄，A₅各自独立地选自：In some embodiments, R2 is selected from:

wherein A ₁ , A ₂ , A ₃ , A ₄ , A ₅ are each independently selected from:

(1) Hydrogen, (2) Dimethylphosphinoyl.

其中A₁和A₅二者之一为氢，另一为二甲基次膦酰基；A₂，A₃，A₄都为氢。In some embodiments, R2 is selected from:

One of A ₁ and A ₅ is hydrogen, and the other is dimethylphosphinoyl; A ₂ , A ₃ and A ₄ are all hydrogen.

In a sixteenth aspect, the present invention provides a compound represented by the following general formula IRS, its stereoisomer, its prodrug, its pharmaceutically acceptable salt or its pharmaceutically acceptable solvate,

where R1 is selected from:

1) C1-C6 alkyl, 2-N,N-dimethylaminoethyl, 2-hydroxyethyl, 2-N,N-diethylaminoethyl, 2-N,N-diisopropyl Aminoethyl, 2-morpholinoethyl, 2-(4-methylpiperazinyl)ethyl, 3-N,N-dimethylaminopropyl, 3-N,N-diethylaminopropyl Base, 3-N,N-diisopropylaminopropyl, 3-morpholinylpropyl, 3-(4-methylpiperazinyl)propyl, C3-C6cycloalkyl, 4-N,N -Dimethylaminocyclohexyl, 4-N,N-diethylaminocyclohexyl, N-methyl-4-piperidinyl, N-ethyl-4-piperidinyl, N-isopropyl-4 -Piperidinyl, 1,3-dimethyl-5-pyrazolyl, 1-methyl-4-pyrazolyl, 3-methyl-5-isoxazolinyl, 1-(N-methyl -4-Piperidinyl)-4-pyrazolyl, 1-(N-tert-butoxycarbonyl-4-piperidinyl)-4-pyrazolyl;

其中Z₁，Z₂，Z₃，Z₄，Z₅各自独立地选自：2)

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from:

(1) hydrogen, fluorine, chlorine, bromine, iodine, nitro, cyano,

(2) C1-C6 alkyl, C1-C6 alkoxy, C1-C6 oxygen-containing alkyl, C1-C6 fluorine-containing alkyl, C1-C6 fluorine-containing alkoxy,

(3) piperidinyl, N-methyl-4-piperidinyl, 4-dimethylaminopiperidinyl, 4-N,N-diethylaminopiperidinyl, 4-N,N-diiso propylaminopiperidinyl, 4-hydroxypiperidinyl, 4-(4-methylpiperazinyl)piperidinyl, 4-(4-ethylpiperazinyl)piperidinyl, 4-(4-iso Propylpiperazinyl)piperidinyl, 4-(4-acetylpiperazinyl)piperidinyl, 4-(4-tert-butoxycarbonylpiperazinyl)piperidinyl, 4-(4-methanesulfonyl Piperazinyl)piperidyl, 4-(4-(2-hydroxyethyl)piperazinyl)piperidinyl, 4-(4-(2-cyanoethyl)piperazinyl)piperidinyl, 4 -(4-(3-Hydroxypropyl)piperazinyl)piperidinyl, 4-(4-(2-N,N-dimethylaminoethyl)piperazinyl)piperidinyl, 4-(4 -(2-N,N-Diethylaminoethyl)piperazinyl)piperidinyl, 4-(4-(3-N,N-dimethylaminopropyl)piperazinyl)piperidinyl, 4-(4-(3-N,N-Diethylaminopropyl)piperazinyl)piperidinyl, 4-(tetrahydropyrrolyl)piperidinyl, 4-(3-N,N-dimethyl ylaminotetrahydropyrrolyl)piperidinyl, 4-(tetrahydropyrrol-1-yl)piperidinyl

(4) 4-methylpiperazinyl, 4-ethylpiperazinyl, 4-isopropylpiperazinyl, 4-acetylpiperazinyl, 4-tert-butoxycarbonylpiperazinyl, 4-methanesulfonic acid Acylpiperazinyl, 4-(2-hydroxyethyl)piperazinyl, 4-(2-cyanoethyl)piperazinyl, 4-(3-hydroxypropyl)piperazinyl, 4-(2- N,N-Dimethylaminoethyl)piperazinyl, 4-(2-N,N-diethylaminoethyl)piperazinyl, 4-(3-N,N-dimethylaminopropyl ) piperazinyl, 4-(3-N,N-diethylaminopropyl)piperazinyl, 4-(N-methyl-4-piperidinyl)piperazinyl, 4-(N-ethyl -4-Piperidinyl)piperazinyl,

(5) N,N-dimethylamino, N,N-diethylamino, N,N-diisopropylamino, 2-N,N-dimethylaminoethylamino, 2-morpholino Ethylamino, 2-(4-methylpiperazinyl)ethylamino, 3-N,N-dimethylaminopropylamino, 3-N,N-diethylaminopropylamino, 3-N ,N-diisopropylaminopropylamino, 3-morpholinopropylamino, 3-(4-methylpiperazinyl)propylamino, N-methylpiperidine-4-amino, N-ethyl piperidine-4-amino, N-isopropylpiperidine-4-amino,

(6) 2-N,N-dimethylaminoethoxy, 2-N,N-diethylaminoethoxy, 2-N,N-diisopropylaminoethoxy, 2-(4 -Methylpiperazinyl)ethoxy, 2-(4-acetylpiperazinyl)ethoxy, 2-morpholinylethoxy, 2-thiophenarinylethoxy, 2-piperidinyl Ethoxy, 3-N,N-dimethylaminopropoxy, 3-N,N-diethylaminopropoxy, 3-N,N-diisopropylaminopropoxy, 3-( 4-Methylpiperazinyl)propoxy, 3-(4-Acetylpiperazinyl)propoxy, 3-morpholinopropoxy, 3-thiophenarinylpropoxy, 3-piperidine pyridin-2-ylmethoxy, pyridin-3-ylmethoxy, pyridin-4-ylmethoxy, phenylmethoxy, monohalogen substituted phenylmethoxy, geminal dihalogen Substituted phenylmethoxy, heterodihalogen substituted phenylmethoxy,

(7) Hydroxysulfonyl, aminosulfonyl, methylaminosulfonyl, ethylaminosulfonyl, propylaminosulfonyl, isopropylaminosulfonyl, cyclopropylaminosulfonyl, cyclobutylaminosulfonyl, cyclopentylamino Sulfonyl, piperidin-1-ylsulfonyl, 4-hydroxypiperidin-1-ylsulfonyl, 4-N,N-dimethylaminopiperidin-1-ylsulfonyl, 4-N,N-di Ethylaminopiperidin-1-ylsulfonyl, tetrahydropyrrolyl-1-sulfonyl, 3-N,N-dimethylaminotetrahydropyrrolyl-1-sulfonyl, 3-N,N-diethyl ylaminotetrahydropyrrolyl-1-sulfonyl, 4-methylpiperazin-1-ylsulfonyl, 4-ethylpiperazinyl-1-sulfonyl, 4-acetylpiperazinyl-1-sulfonyl , 4-tert-butoxycarbonylpiperazinyl-1-sulfonyl, 4-(2-hydroxyethyl)piperazinyl-1-sulfonyl, 4-(2-cyanoethyl)piperazinyl-1- Sulfonyl, 4-(2-N,N-dimethylaminoethyl)piperazinyl-1-sulfonyl, 4-(2-N,N-diethylethyl)piperazinyl-1-sulfonyl Acyl, 4-(3-hydroxypropyl)piperazinyl-1-sulfonyl, 4-(3-N,N-dimethylaminopropyl)piperazinyl-1-sulfonyl, 4-(3- N,N-Diethylaminopropyl)piperazinyl-1-sulfonyl, morpholinyl-1-sulfonyl, 3,5-dimethylmorpholinyl-1-sulfonyl, 4-(4- Methyl-piperazin-1-yl)piperidin-1-ylsulfonyl, 4-(4-ethyl-1-piperazinyl)piperidin-1-ylsulfonyl, 4-(4-acetyl- 1-Piperazinyl)piperidin-1-ylsulfonyl, 4-(N-methyl-4-piperidinyl)piperazinyl-1-sulfonyl,

(8) Hydroxycarbonyl, aminocarbonyl, methylaminocarbonyl, ethylaminocarbonyl, propylaminocarbonyl, isopropylaminocarbonyl, cyclopropylaminocarbonyl, cyclobutylaminocarbonyl, cyclopentylaminocarbonyl, piperidinyl-1- Carbonyl, 4-hydroxypiperidinyl-1-carbonyl, 4-N,N-dimethylaminopiperidinyl-1-carbonyl, 4-N,N-diethylaminopiperidinyl-1-carbonyl, tetra Hydropyrrolyl-1-carbonyl, 3-N,N-dimethylaminotetrahydropyrrolyl-1-carbonyl, 3-N,N-diethylaminotetrahydropyrrolyl-1-carbonyl, 4-methyl Piperazin-1-ylcarbonyl, 4-ethylpiperazinyl-1-carbonyl, 4-acetylpiperazinyl-1-carbonyl, 4-tert-butoxycarbonylpiperazinyl-1-carbonyl, 4-(2 -Hydroxyethyl)piperazinyl-1-carbonyl, 4-(2-cyanoethyl)piperazinyl-1-carbonyl, 4-(2-N,N-dimethylaminoethyl)piperazinyl -1-carbonyl, 4-(2-N,N-diethylaminoethyl)piperazinyl-1-carbonyl, 4-(3-hydroxypropyl)piperazinyl-1-carbonyl, 4-(3 -N,N-Dimethylaminopropyl)piperazinyl-1-carbonyl, 4-(3-N,N-diethylaminopropyl)piperazinyl-1-carbonyl, morpholinyl-1- Carbonyl, 3,5-dimethylmorpholinyl-1-carbonyl, 4-(4-methyl-piperazin-1-yl)piperidin-1-ylcarbonyl, 4-(4-ethyl-1- Piperazinyl)piperidinyl-1-carbonyl, 4-(4-acetyl-1-piperazinyl)piperidinyl-1-carbonyl, 4-(N-methyl-4-piperidinyl)piperazine yl-1-carbonyl, methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, tert-butoxycarbonyl,

(9) carbamoylamino, methylcarbamoylamino, ethylcarbamoylamino, propylcarbamoylamino, isopropylcarbamoylamino, cyclopropylcarbamoylamino, cyclobutylcarbamoylamino, cyclo Amylcarbamoylamino, piperidinyl-1-carboxamido, 4-hydroxypiperidinyl-1-carboxamido, 4-N,N-dimethylaminopiperidinyl-1-carboxamido, 4-N,N-Diethylaminopiperidinyl-1-carboxamido, tetrahydropyrrolyl-1-carboxamido, 3-N,N-dimethylaminotetrahydropyrrolyl-1-carboxyl Amino, 3-N,N-diethylaminotetrahydropyrrolyl-1-carboxamido, 4-methylpiperazinyl-1-carboxamido, 4-ethylpiperazinyl-1-carboxamido , 4-Acetyl piperazinyl-1-carboxamido, 4-tert-butoxycarbonyl piperazinyl-1-carboxamido, 4-(2-hydroxyethyl) piperazinyl-1-carboxamido, 4-(2-cyanoethyl)piperazinyl-1-carboxamido, 4-(2-N,N-dimethylaminoethyl)piperazinyl-1-carboxamido, 4-(2 -N,N-Diethylaminoethyl)piperazinyl-1-carboxamido, 4-(3-hydroxypropyl)piperazinyl-1-carboxamido, 4-(3-N,N- Dimethylaminopropyl)piperazinyl-1-carboxamido, 4-(3-N,N-diethylaminopropyl)piperazinyl-1-carboxamido, morpholino-1-methyl amido, 3,5-dimethylmorpholino-1-carboxamido, 4-(4-methyl-piperazin-1-yl)piperidinyl-1-carboxamido, 4-(4- Ethyl-1-piperazinyl)piperidinyl-1-carboxamido, 4-(4-acetyl-1-piperazinyl)piperidinyl-1-carboxamido, 4-(N-methyl -4-Piperidinyl)piperazinyl-1-carboxamido; or

(10) Z ₂ and Z ₃ or Z ₃ and Z ₄ form a nitrogen- or oxygen-containing substituted or unsubstituted five-membered ring or six-membered ring, and the substituents can be selected from the same substituents as Z ₁ ;

其中A₁，A₂，A₃，A₄，A₅各自独立地选自：R2 is selected from

wherein A ₁ , A ₂ , A ₃ , A ₄ , A ₅ are each independently selected from:

(1) hydrogen, fluorine, chlorine, bromine, iodine, cyano, trifluoromethyl, trifluoromethoxy, nitro,

(2) Methylthio, ethylthio, isopropylthio, methylsulfinyl, ethylsulfinyl, isopropylsulfinyl, methylsulfonyl, ethylsulfonyl, isopropylsulfonyl, tert-butanesulfonyl , methanesulfonylamino, methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, tert-butoxycarbonyl, methylaminocarbonyl, ethyl Aminocarbonyl, propylaminocarbonyl, isopropylaminocarbonyl, dimethylaminocarbonyl, cyclopropylaminocarbonyl, cyclobutylaminocarbonyl, cyclopentylaminocarbonyl, dimethylphosphinoyl, diethylphosphinoyl, diethylaminocarbonyl Isopropylphosphinoyl.

其中Z₁，Z₂，Z₃，Z₄，Z₅各自独立地选自：In some embodiments, R1 is selected from

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from:

(1) Hydrogen,

(2) C1-C6 alkoxy,

(3) piperidinyl, N-methyl-4-piperidinyl, 4--dimethylaminopiperidinyl, 4-N,N-diethylaminopiperidinyl, 4-N,N-diethylaminopiperidinyl Isopropylaminopiperidinyl, 4-hydroxypiperidinyl, 4-(4-methylpiperazinyl)piperidinyl, 4-(4-ethylpiperazinyl)piperidinyl, 4-(4- Isopropylpiperazinyl)piperidinyl, 4-(4-acetylpiperazinyl)piperidinyl, 4-(4-tert-butoxycarbonylpiperazinyl)piperidinyl, 4-(4-methanesulfonyl) acylpiperazinyl)piperidyl, 4-(4-(2-hydroxyethyl)piperazinyl)piperidinyl, 4-(4-(2-cyanoethyl)piperazinyl)piperidinyl, 4-(4-(3-Hydroxypropyl)piperazinyl)piperidinyl, 4-(4-(2-N,N-dimethylaminoethyl)piperazinyl)piperidinyl, 4-( 4-(2-N,N-Diethylaminoethyl)piperazinyl)piperidinyl, 4-(4-(3-N,N-dimethylaminopropyl)piperazinyl)piperidinyl , 4-(4-(3-N,N-diethylaminopropyl)piperazinyl)piperidinyl, 4-(tetrahydropyrrolyl)piperidinyl, 4-(3-N,N-di Methylaminotetrahydropyrrolyl)piperidinyl, 4-(tetrahydropyrrol-1-yl)piperidinyl;

(4) 4-methylpiperazinyl, 4-ethylpiperazinyl, 4-isopropylpiperazinyl, 4-acetylpiperazinyl, 4-tert-butoxycarbonylpiperazinyl, 4-methanesulfonic acid Acylpiperazinyl, 4-(2-hydroxyethyl)piperazinyl, 4-(2-cyanoethyl)piperazinyl, 4-(3-hydroxypropyl)piperazinyl, 4-(2- N,N-Dimethylaminoethyl)piperazinyl, 4-(2-N,N-diethylaminoethyl)piperazinyl, 4-(3-N,N-dimethylaminopropyl ) piperazinyl, 4-(3-N,N-diethylaminopropyl)piperazinyl, 4-(N-methyl-4-piperidinyl)piperazinyl, 4-(N-ethyl -4-Piperidinyl)piperazinyl or

(5) Z ₂ and Z ₃ or Z ₃ and Z ₄ form a nitrogen- or oxygen-containing substituted or unsubstituted five-membered ring, and the substituents may be selected from the same substituents as those of Z ₁ .

其中Z₁，Z₂，Z₃，Z₄，Z₅各自独立地任选自：In some embodiments, R1 is selected from

Wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from:

(1) Hydrogen,

(2) C1-C6 alkoxy,

(3) 4-(Tetrahydropyrrol-1-yl)piperidinyl, 4-methylpiperazinyl, 4-(4-methylpiperazinyl)piperidinyl, 4-dimethylamino-piperidinyl ;

(4) Z ₂ and Z ₃ can form a nitrogen-containing substituted or unsubstituted five-membered ring

其中In some embodiments, R1 is selected from:

in

One of Z ₁ and Z ₅ is hydrogen, and the other is methoxy;

Z ₃ is selected from: 4-dimethylamino-piperidinyl, 4-methylpiperazinyl, 4-(4-methylpiperazinyl)piperidinyl, 4-(tetrahydropyrrol-1-yl)piperidine pyridyl, or

Z ₂ and Z ₃ or Z ₃ and Z ₄ form

其中A₁，A₂，A₃，A₄，A₅各自独立地任选自：In some embodiments, R2 is selected from:

Wherein A ₁ , A ₂ , A ₃ , A ₄ , A ₅ are each independently selected from:

(1) Hydrogen; (2) Diisopropylphosphinoyl, diethylphosphinoyl.

其中A₁和A₅二者之一为氢，另一为二异丙基次膦酰基或二乙基次膦酰基；A₂，A₃，A₄都为氢。In some embodiments, R2 is selected from:

One of A ₁ and A ₅ is hydrogen, the other is diisopropylphosphinoyl or diethylphosphinoyl; A ₂ , A ₃ and A ₄ are all hydrogen.

A seventeenth aspect, the present invention provides a compound represented by the following general formula IL, its stereoisomer, its prodrug, its pharmaceutically acceptable salt or its pharmaceutically acceptable solvate,

Wherein, A is methylene; X is NH;

R1 is selected from:

1) C1-C6 alkyl, 2-N,N-dimethylaminoethyl, 2-hydroxyethyl, 2-N,N-diethylaminoethyl, 2-N,N-diisopropyl Aminoethyl, 2-morpholinoethyl, 2-(4-methylpiperazinyl)ethyl, 3-N,N-dimethylaminopropyl, 3-N,N-diethylaminopropyl Base, 3-N,N-diisopropylaminopropyl, 3-morpholinylpropyl, 3-(4-methylpiperazinyl)propyl, C3-C6cycloalkyl, 4-N,N -Dimethylaminocyclohexyl, 4-N,N-diethylaminocyclohexyl, N-methyl-4-piperidinyl, N-ethyl-4-piperidinyl, N-isopropyl-4 -Piperidinyl, 1,3-dimethyl-5-pyrazolyl, 1-methyl-4-pyrazolyl, 3-methyl-5-isoxazolinyl, 1-(N-methyl -4-Piperidinyl)-4-pyrazolyl, 1-(N-tert-butoxycarbonyl-4-piperidinyl)-4-pyrazolyl;

其中Z₁，Z₂，Z₃，Z₄，Z₅各自独立地选自：2)

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from:

(1) hydrogen, fluorine, chlorine, bromine, iodine, nitro, cyano,

(2) C1-C6 alkyl, C1-C6 alkoxy, C1-C6 oxygen-containing alkyl, C1-C6 fluorine-containing alkyl, C1-C6 fluorine-containing alkoxy,

(3) piperidinyl, N-methyl-4-piperidinyl, 4-N,N-dimethylaminopiperidinyl, 4-N,N-diethylaminopiperidinyl, 4-N, N-diisopropylaminopiperidinyl, 4-hydroxypiperidinyl, 4-(4-methylpiperazinyl)piperidinyl, 4-(4-ethylpiperazinyl)piperidinyl, 4- (4-Isopropylpiperazinyl)piperidinyl, 4-(4-acetylpiperazinyl)piperidinyl, 4-(4-tert-butoxycarbonylpiperazinyl)piperidinyl, 4-(4 -Methylsulfonylpiperazinyl)piperidyl, 4-(4-(2-hydroxyethyl)piperazinyl)piperidyl, 4-(4-(2-cyanoethyl)piperazinyl)piperidyl pyridyl, 4-(4-(3-hydroxypropyl)piperazinyl)piperidinyl, 4-(4-(2-N,N-dimethylaminoethyl)piperazinyl)piperidinyl, 4-(4-(2-N,N-Diethylaminoethyl)piperazinyl)piperidyl, 4-(4-(3-N,N-dimethylaminopropyl)piperazinyl) piperidinyl, 4-(4-(3-N,N-diethylaminopropyl)piperazinyl)piperidinyl, 4-(tetrahydropyrrolyl)piperidinyl, 4-(3-N, N-dimethylaminotetrahydropyrrolyl) piperidinyl,

(4) 4-methylpiperazinyl, 4-ethylpiperazinyl, 4-isopropylpiperazinyl, 4-acetylpiperazinyl, 4-tert-butoxycarbonylpiperazinyl, 4-methanesulfonic acid Acylpiperazinyl, 4-(2-hydroxyethyl)piperazinyl, 4-(2-cyanoethyl)piperazinyl, 4-(3-hydroxypropyl)piperazinyl, 4-(2- N,N-Dimethylaminoethyl)piperazinyl, 4-(2-N,N-diethylaminoethyl)piperazinyl, 4-(3-N,N-dimethylaminopropyl ) piperazinyl, 4-(3-N,N-diethylaminopropyl)piperazinyl, 4-(N-methyl-4-piperidinyl)piperazinyl, 4-(N-ethyl -4-Piperidinyl)piperazinyl,

(5) N,N-dimethylamino, N,N-diethylamino, N,N-diisopropylamino, 2-N,N-dimethylaminoethylamino, 2-morpholino Ethylamino, 2-(4-methylpiperazinyl)ethylamino, 3-N,N-dimethylaminopropylamino, 3-N,N-diethylaminopropylamino, 3-N ,N-diisopropylaminopropylamino, 3-morpholinopropylamino, 3-(4-methylpiperazinyl)propylamino, N-methylpiperidine-4-amino, N-ethyl piperidine-4-amino, N-isopropylpiperidine-4-amino,

(6) 2-N,N-dimethylaminoethoxy, 2-N,N-diethylaminoethoxy, 2-N,N-diisopropylaminoethoxy, 2-(4 -Methylpiperazinyl)ethoxy, 2-(4-acetylpiperazinyl)ethoxy, 2-morpholinylethoxy, 2-thiophenarinylethoxy, 2-piperidinyl Ethoxy, 3-N,N-dimethylaminopropoxy, 3-N,N-diethylaminopropoxy, 3-N,N-diisopropylaminopropoxy, 3-( 4-Methylpiperazinyl)propoxy, 3-(4-Acetylpiperazinyl)propoxy, 3-morpholinopropoxy, 3-thiophenarinylpropoxy, 3-piperidine pyridin-2-ylmethoxy, pyridin-3-ylmethoxy, pyridin-4-ylmethoxy, phenylmethoxy, monohalogen substituted phenylmethoxy, geminal dihalogen Substituted phenylmethoxy, heterodihalogen substituted phenylmethoxy,

(7) Hydroxysulfonyl, aminosulfonyl, methylaminosulfonyl, ethylaminosulfonyl, propylaminosulfonyl, isopropylaminosulfonyl, cyclopropylaminosulfonyl, cyclobutylaminosulfonyl, cyclopentylamino Sulfonyl, piperidin-1-ylsulfonyl, 4-hydroxypiperidin-1-ylsulfonyl, 4-N,N-dimethylaminopiperidin-1-ylsulfonyl, 4-N,N-di Ethylaminopiperidin-1-ylsulfonyl, tetrahydropyrrolyl-1-sulfonyl, 3-N,N-dimethylaminotetrahydropyrrolyl-1-sulfonyl, 3-N,N-diethyl ylaminotetrahydropyrrolyl-1-sulfonyl, 4-methylpiperazin-1-ylsulfonyl, 4-ethylpiperazinyl-1-sulfonyl, 4-acetylpiperazinyl-1-sulfonyl , 4-tert-butoxycarbonylpiperazinyl-1-sulfonyl, 4-(2-hydroxyethyl)piperazinyl-1-sulfonyl, 4-(2-cyanoethyl)piperazinyl-1- Sulfonyl, 4-(2-N,N-dimethylaminoethyl)piperazinyl-1-sulfonyl, 4-(2-N,N-diethylethyl)piperazinyl-1-sulfonyl Acyl, 4-(3-hydroxypropyl)piperazinyl-1-sulfonyl, 4-(3-N,N-dimethylaminopropyl)piperazinyl-1-sulfonyl, 4-(3- N,N-Diethylaminopropyl)piperazinyl-1-sulfonyl, morpholinyl-1-sulfonyl, 3,5-dimethylmorpholinyl-1-sulfonyl, 4-(4- Methyl-piperazin-1-yl)piperidin-1-ylsulfonyl, 4-(4-ethyl-1-piperazinyl)piperidin-1-ylsulfonyl, 4-(4-acetyl- 1-Piperazinyl)piperidin-1-ylsulfonyl, 4-(N-methyl-4-piperidinyl)piperazinyl-1-sulfonyl,

(8) Hydroxycarbonyl, aminocarbonyl, methylaminocarbonyl, ethylaminocarbonyl, propylaminocarbonyl, isopropylaminocarbonyl, cyclopropylaminocarbonyl, cyclobutylaminocarbonyl, cyclopentylaminocarbonyl, piperidinyl-1- Carbonyl, 4-hydroxypiperidinyl-1-carbonyl, 4-N,N-dimethylaminopiperidinyl-1-carbonyl, 4-N,N-diethylaminopiperidinyl-1-carbonyl, tetra Hydropyrrolyl-1-carbonyl, 3-N,N-dimethylaminotetrahydropyrrolyl-1-carbonyl, 3-N,N-diethylaminotetrahydropyrrolyl-1-carbonyl, 4-methyl Piperazin-1-ylcarbonyl, 4-ethylpiperazinyl-1-carbonyl, 4-acetylpiperazinyl-1-carbonyl, 4-tert-butoxycarbonylpiperazinyl-1-carbonyl, 4-(2 -Hydroxyethyl)piperazinyl-1-carbonyl, 4-(2-cyanoethyl)piperazinyl-1-carbonyl, 4-(2-N,N-dimethylaminoethyl)piperazinyl -1-carbonyl, 4-(2-N,N-diethylaminoethyl)piperazinyl-1-carbonyl, 4-(3-hydroxypropyl)piperazinyl-1-carbonyl, 4-(3 -N,N-Dimethylaminopropyl)piperazinyl-1-carbonyl, 4-(3-N,N-diethylaminopropyl)piperazinyl-1-carbonyl, morpholinyl-1- Carbonyl, 3,5-dimethylmorpholinyl-1-carbonyl, 4-(4-methyl-piperazin-1-yl)piperidin-1-ylcarbonyl, 4-(4-ethyl-1- Piperazinyl)piperidinyl-1-carbonyl, 4-(4-acetyl-1-piperazinyl)piperidinyl-1-carbonyl, 4-(N-methyl-4-piperidinyl)piperazine yl-1-carbonyl, methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, tert-butoxycarbonyl,

(9) carbamoylamino, methylcarbamoylamino, ethylcarbamoylamino, propylcarbamoylamino, isopropylcarbamoylamino, cyclopropylcarbamoylamino, cyclobutylcarbamoylamino, cyclo Amylcarbamoylamino, piperidinyl-1-carboxamido, 4-hydroxypiperidinyl-1-carboxamido, 4-N,N-dimethylaminopiperidinyl-1-carboxamido, 4-N,N-Diethylaminopiperidinyl-1-carboxamido, tetrahydropyrrolyl-1-carboxamido, 3-N,N-dimethylaminotetrahydropyrrolyl-1-carboxyl Amino, 3-N,N-diethylaminotetrahydropyrrolyl-1-carboxamido, 4-methylpiperazinyl-1-carboxamido, 4-ethylpiperazinyl-1-carboxamido , 4-Acetyl piperazinyl-1-carboxamido, 4-tert-butoxycarbonyl piperazinyl-1-carboxamido, 4-(2-hydroxyethyl) piperazinyl-1-carboxamido, 4-(2-cyanoethyl)piperazinyl-1-carboxamido, 4-(2-N,N-dimethylaminoethyl)piperazinyl-1-carboxamido, 4-(2 -N,N-Diethylaminoethyl)piperazinyl-1-carboxamido, 4-(3-hydroxypropyl)piperazinyl-1-carboxamido, 4-(3-N,N- Dimethylaminopropyl)piperazinyl-1-carboxamido, 4-(3-N,N-diethylaminopropyl)piperazinyl-1-carboxamido, morpholino-1-methyl amido, 3,5-dimethylmorpholino-1-carboxamido, 4-(4-methyl-piperazin-1-yl)piperidinyl-1-carboxamido, 4-(4- Ethyl-1-piperazinyl)piperidinyl-1-carboxamido, 4-(4-acetyl-1-piperazinyl)piperidinyl-1-carboxamido, 4-(N-methyl -4-Piperidinyl)piperazinyl-1-carboxamido; or

(10) Z ₂ and Z ₃ or Z ₃ and Z ₄ form a nitrogen- or oxygen-containing substituted or unsubstituted five-membered ring or six-membered ring, and the substituents can be selected from the same substituents as Z ₁ ;

其中A₁，A₂，A₃，A₄，A₅各自独立地选自：R2 is selected from

wherein A ₁ , A ₂ , A ₃ , A ₄ , A ₅ are each independently selected from:

(1) hydrogen, fluorine, chlorine, bromine, iodine, cyano, trifluoromethyl, trifluoromethoxy, nitro,

(2) methylthio, ethylthio, isopropylthio, methylsulfinyl, ethylsulfinyl, isopropylsulfinyl, methylsulfonyl, ethylsulfonyl, isopropylsulfonyl, methanesulfonylamino , methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, tert-butoxycarbonyl, methylaminocarbonyl, ethylaminocarbonyl, propylamino Carbonyl, isopropylaminocarbonyl, cyclopropylaminocarbonyl, cyclobutylaminocarbonyl, cyclopentylaminocarbonyl, dimethylphosphinoyl, diethylphosphinoyl, diisopropylphosphinoyl.

其中Z₁，Z₂，Z₃，Z₄，Z₅各自独立地选自：In some embodiments, R1 is selected from:

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from:

(1) Hydrogen,

(2) C1-C6 alkoxy,

(3) piperidinyl, N-methyl-4-piperidinyl, 4-N,N-dimethylaminopiperidinyl, 4-N,N-diethylaminopiperidinyl, 4-N, N-diisopropylaminopiperidinyl, 4-hydroxypiperidinyl

(4) 4-(4-Methylpiperazinyl)piperidinyl, 4-(4-ethylpiperazinyl)piperidinyl, 4-(4-isopropylpiperazinyl)piperidinyl, 4 -(4-Acetylpiperazinyl)piperidinyl, 4-(4-tert-butoxycarbonylpiperazinyl)piperidinyl, 4-(4-methanesulfonylpiperazinyl)piperidinyl, 4-( 4-(2-Hydroxyethyl)piperazinyl)piperidinyl, 4-(4-(2-cyanoethyl)piperazinyl)piperidinyl, 4-(4-(3-hydroxypropyl) Piperazinyl) piperidinyl, 4-(4-(2-N,N-dimethylaminoethyl)piperazinyl)piperidinyl, 4-(4-(2-N,N-diethyl) Aminoethyl)piperazinyl)piperidinyl, 4-(4-(3-N,N-dimethylaminopropyl)piperazinyl)piperidinyl, 4-(4-(3-N,N -Diethylaminopropyl)piperazinyl)piperidinyl, 4-(tetrahydropyrrol-1-yl)piperidinyl, 4-(3-N,N-dimethylaminotetrahydropyrrolyl)piperidyl pyridyl,

(5) 4-methylpiperazinyl, 4-ethylpiperazinyl, 4-isopropylpiperazinyl, 4-acetylpiperazinyl, 4-tert-butoxycarbonylpiperazinyl, 4-methanesulfonic acid Acylpiperazinyl, 4-(2-hydroxyethyl)piperazinyl, 4-(2-cyanoethyl)piperazinyl, 4-(3-hydroxypropyl)piperazinyl, 4-(2- N,N-Dimethylaminoethyl)piperazinyl, 4-(2-N,N-diethylaminoethyl)piperazinyl, 4-(3-N,N-dimethylaminopropyl ) piperazinyl, 4-(3-N,N-diethylaminopropyl)piperazinyl, 4-(N-methyl-4-piperidinyl)piperazinyl, 4-(N-ethyl -4-Piperidinyl)piperazinyl, or

(6) Z ₂ and Z ₃ or Z ₃ and Z ₄ form a nitrogen- or oxygen-containing substituted or unsubstituted five-membered ring, and the substituents can be selected from the same substituents as those of Z ₁ .

In some embodiments, R1 is selected from:

其中Z₁，Z₂，Z₃，Z₄，Z₅各自独立地选自：

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from:

(1) Hydrogen,

(2) Methoxy,

(3) 4-hydroxypiperidinyl, 4-(4-methylpiperazinyl) piperidinyl,

(4) 4-methylpiperazinyl, or

(5) Z ₂ and Z ₃ or Z ₃ and Z ₄ form

In some embodiments, R1 is selected from:

其中Z₁和Z₅二者之一为氢，另一为甲氧基；Z₄为氢；

Wherein one of Z ₁ and Z ₅ is hydrogen, the other is methoxy; Z ₄ is hydrogen;

Z ₃ is selected from: 4-hydroxypiperidinyl, 4-methylpiperazinyl, 4-(4-methylpiperazinyl)piperidinyl, or

Z ₂ forms with Z ₃

其中A₁，A₂，A₃，A₄，A₅各自独立地选自：In some embodiments, R2 is selected from:

wherein A ₁ , A ₂ , A ₃ , A ₄ , A ₅ are each independently selected from:

(1) Hydrogen, (2) Methanesulfonyl.

其中A₁和A₅二者之一为氢，另一为甲磺酰基；A₂，A₃，A₄都为氢。In some embodiments, R2 is selected from:

One of A ₁ and A ₅ is hydrogen, and the other is methanesulfonyl; A ₂ , A ₃ and A ₄ are all hydrogen.

In an eighteenth aspect, the present invention provides a compound represented by the following general formula IM, its stereoisomer, its prodrug, its pharmaceutically acceptable salt or its pharmaceutically acceptable solvate,

Wherein, A is methylene; X is NH;

R1 is selected from:

1) C1-C6 alkyl, 2-N,N-dimethylaminoethyl, 2-hydroxyethyl, 2-N,N-diethylaminoethyl, 2-N,N-diisopropyl Aminoethyl, 2-morpholinoethyl, 2-(4-methylpiperazinyl)ethyl, 3-N,N-dimethylaminopropyl, 3-N,N-diethylaminopropyl Base, 3-N,N-diisopropylaminopropyl, 3-morpholinylpropyl, 3-(4-methylpiperazinyl)propyl, C3-C6cycloalkyl, 4-N,N -Dimethylaminocyclohexyl, 4-N,N-diethylaminocyclohexyl, N-methyl-4-piperidinyl, N-ethyl-4-piperidinyl, N-isopropyl-4 -Piperidinyl, 1,3-dimethyl-5-pyrazolyl, 1-methyl-4-pyrazolyl, 3-methyl-5-isoxazolinyl, 1-(N-methyl -4-Piperidinyl)-4-pyrazolyl, 1-(N-tert-butoxycarbonyl-4-piperidinyl)-4-pyrazolyl;

其中Z₁，Z₂，Z₃，Z₄，Z₅各自独立地选自：2)

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from:

(1) hydrogen, fluorine, chlorine, bromine, iodine, nitro, cyano,

(2) C1-C6 alkyl, C1-C6 alkoxy, C1-C6 oxygen-containing alkyl, C1-C6 fluorine-containing alkyl, C1-C6 fluorine-containing alkoxy,

(3) piperidinyl, N-methyl-4-piperidinyl, 4-N,N-dimethylaminopiperidinyl, 4-N,N-diethylaminopiperidinyl, 4-N, N-diisopropylaminopiperidinyl, 4-hydroxypiperidinyl, 4-(4-methylpiperazinyl)piperidinyl, 4-(4-ethylpiperazinyl)piperidinyl, 4- (4-Isopropylpiperazinyl)piperidinyl, 4-(4-acetylpiperazinyl)piperidinyl, 4-(4-tert-butoxycarbonylpiperazinyl)piperidinyl, 4-(4 -Methylsulfonylpiperazinyl)piperidyl, 4-(4-(2-hydroxyethyl)piperazinyl)piperidyl, 4-(4-(2-cyanoethyl)piperazinyl)piperidyl pyridyl, 4-(4-(3-hydroxypropyl)piperazinyl)piperidinyl, 4-(4-(2-N,N-dimethylaminoethyl)piperazinyl)piperidinyl, 4-(4-(2-N,N-Diethylaminoethyl)piperazinyl)piperidyl, 4-(4-(3-N,N-dimethylaminopropyl)piperazinyl) piperidinyl, 4-(4-(3-N,N-diethylaminopropyl)piperazinyl)piperidinyl, 4-(tetrahydropyrrolyl)piperidinyl, 4-(3-N, N-dimethylaminotetrahydropyrrolyl) piperidinyl,

(4) 4-methylpiperazinyl, 4-ethylpiperazinyl, 4-isopropylpiperazinyl, 4-acetylpiperazinyl, 4-tert-butoxycarbonylpiperazinyl, 4-methanesulfonic acid Acylpiperazinyl, 4-(2-hydroxyethyl)piperazinyl, 4-(2-cyanoethyl)piperazinyl, 4-(3-hydroxypropyl)piperazinyl, 4-(2- N,N-Dimethylaminoethyl)piperazinyl, 4-(2-N,N-diethylaminoethyl)piperazinyl, 4-(3-N,N-dimethylaminopropyl ) piperazinyl, 4-(3-N,N-diethylaminopropyl)piperazinyl, 4-(N-methyl-4-piperidinyl)piperazinyl, 4-(N-ethyl -4-Piperidinyl)piperazinyl,

(5) N,N-dimethylamino, N,N-diethylamino, N,N-diisopropylamino, 2-N,N-dimethylaminoethylamino, 2-morpholino Ethylamino, 2-(4-methylpiperazinyl)ethylamino, 3-N,N-dimethylaminopropylamino, 3-N,N-diethylaminopropylamino, 3-N ,N-diisopropylaminopropylamino, 3-morpholinopropylamino, 3-(4-methylpiperazinyl)propylamino, N-methylpiperidine-4-amino, N-ethyl piperidine-4-amino, N-isopropylpiperidine-4-amino,

(6) 2-N,N-dimethylaminoethoxy, 2-N,N-diethylaminoethoxy, 2-N,N-diisopropylaminoethoxy, 2-(4 -Methylpiperazinyl)ethoxy, 2-(4-acetylpiperazinyl)ethoxy, 2-morpholinylethoxy, 2-thiophenarinylethoxy, 2-piperidinyl Ethoxy, 3-N,N-dimethylaminopropoxy, 3-N,N-diethylaminopropoxy, 3-N,N-diisopropylaminopropoxy, 3-( 4-Methylpiperazinyl)propoxy, 3-(4-Acetylpiperazinyl)propoxy, 3-morpholinopropoxy, 3-thiophenarinylpropoxy, 3-piperidine pyridin-2-ylmethoxy, pyridin-3-ylmethoxy, pyridin-4-ylmethoxy, phenylmethoxy, monohalogen substituted phenylmethoxy, geminal dihalogen Substituted phenylmethoxy, heterodihalogen substituted phenylmethoxy,

(7) Hydroxysulfonyl, aminosulfonyl, methylaminosulfonyl, ethylaminosulfonyl, propylaminosulfonyl, isopropylaminosulfonyl, cyclopropylaminosulfonyl, cyclobutylaminosulfonyl, cyclopentylamino Sulfonyl, piperidin-1-ylsulfonyl, 4-hydroxypiperidin-1-ylsulfonyl, 4-N,N-dimethylaminopiperidin-1-ylsulfonyl, 4-N,N-di Ethylaminopiperidin-1-ylsulfonyl, tetrahydropyrrolyl-1-sulfonyl, 3-N,N-dimethylaminotetrahydropyrrolyl-1-sulfonyl, 3-N,N-diethyl ylaminotetrahydropyrrolyl-1-sulfonyl, 4-methylpiperazin-1-ylsulfonyl, 4-ethylpiperazinyl-1-sulfonyl, 4-acetylpiperazinyl-1-sulfonyl , 4-tert-butoxycarbonylpiperazinyl-1-sulfonyl, 4-(2-hydroxyethyl)piperazinyl-1-sulfonyl, 4-(2-cyanoethyl)piperazinyl-1- Sulfonyl, 4-(2-N,N-dimethylaminoethyl)piperazinyl-1-sulfonyl, 4-(2-N,N-diethylethyl)piperazinyl-1-sulfonyl Acyl, 4-(3-hydroxypropyl)piperazinyl-1-sulfonyl, 4-(3-N,N-dimethylaminopropyl)piperazinyl-1-sulfonyl, 4-(3- N,N-Diethylaminopropyl)piperazinyl-1-sulfonyl, morpholinyl-1-sulfonyl, 3,5-dimethylmorpholinyl-1-sulfonyl, 4-(4- Methyl-piperazin-1-yl)piperidin-1-ylsulfonyl, 4-(4-ethyl-1-piperazinyl)piperidin-1-ylsulfonyl, 4-(4-acetyl- 1-Piperazinyl)piperidin-1-ylsulfonyl, 4-(N-methyl-4-piperidinyl)piperazinyl-1-sulfonyl,

(8) Hydroxycarbonyl, aminocarbonyl, methylaminocarbonyl, ethylaminocarbonyl, propylaminocarbonyl, isopropylaminocarbonyl, cyclopropylaminocarbonyl, cyclobutylaminocarbonyl, cyclopentylaminocarbonyl, piperidinyl-1- Carbonyl, 4-hydroxypiperidinyl-1-carbonyl, 4-N,N-dimethylaminopiperidinyl-1-carbonyl, 4-N,N-diethylaminopiperidinyl-1-carbonyl, tetra Hydropyrrolyl-1-carbonyl, 3-N,N-dimethylaminotetrahydropyrrolyl-1-carbonyl, 3-N,N-diethylaminotetrahydropyrrolyl-1-carbonyl, 4-methyl Piperazin-1-ylcarbonyl, 4-ethylpiperazinyl-1-carbonyl, 4-acetylpiperazinyl-1-carbonyl, 4-tert-butoxycarbonylpiperazinyl-1-carbonyl, 4-(2 -Hydroxyethyl)piperazinyl-1-carbonyl, 4-(2-cyanoethyl)piperazinyl-1-carbonyl, 4-(2-N,N-dimethylaminoethyl)piperazinyl -1-carbonyl, 4-(2-N,N-diethylaminoethyl)piperazinyl-1-carbonyl, 4-(3-hydroxypropyl)piperazinyl-1-carbonyl, 4-(3 -N,N-Dimethylaminopropyl)piperazinyl-1-carbonyl, 4-(3-N,N-diethylaminopropyl)piperazinyl-1-carbonyl, morpholinyl-1- Carbonyl, 3,5-dimethylmorpholinyl-1-carbonyl, 4-(4-methyl-piperazin-1-yl)piperidin-1-ylcarbonyl, 4-(4-ethyl-1- Piperazinyl)piperidinyl-1-carbonyl, 4-(4-acetyl-1-piperazinyl)piperidinyl-1-carbonyl, 4-(N-methyl-4-piperidinyl)piperazine yl-1-carbonyl, methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, tert-butoxycarbonyl,

(9) carbamoylamino, methylcarbamoylamino, ethylcarbamoylamino, propylcarbamoylamino, isopropylcarbamoylamino, cyclopropylcarbamoylamino, cyclobutylcarbamoylamino, cyclo Amylcarbamoylamino, piperidinyl-1-carboxamido, 4-hydroxypiperidinyl-1-carboxamido, 4-N,N-dimethylaminopiperidinyl-1-carboxamido, 4-N,N-Diethylaminopiperidinyl-1-carboxamido, tetrahydropyrrolyl-1-carboxamido, 3-N,N-dimethylaminotetrahydropyrrolyl-1-carboxyl Amino, 3-N,N-diethylaminotetrahydropyrrolyl-1-carboxamido, 4-methylpiperazinyl-1-carboxamido, 4-ethylpiperazinyl-1-carboxamido , 4-Acetyl piperazinyl-1-carboxamido, 4-tert-butoxycarbonyl piperazinyl-1-carboxamido, 4-(2-hydroxyethyl) piperazinyl-1-carboxamido, 4-(2-cyanoethyl)piperazinyl-1-carboxamido, 4-(2-N,N-dimethylaminoethyl)piperazinyl-1-carboxamido, 4-(2 -N,N-Diethylaminoethyl)piperazinyl-1-carboxamido, 4-(3-hydroxypropyl)piperazinyl-1-carboxamido, 4-(3-N,N- Dimethylaminopropyl)piperazinyl-1-carboxamido, 4-(3-N,N-diethylaminopropyl)piperazinyl-1-carboxamido, morpholino-1-methyl amido, 3,5-dimethylmorpholino-1-carboxamido, 4-(4-methyl-piperazin-1-yl)piperidinyl-1-carboxamido, 4-(4- Ethyl-1-piperazinyl)piperidinyl-1-carboxamido, 4-(4-acetyl-1-piperazinyl)piperidinyl-1-carboxamido, 4-(N-methyl -4-Piperidinyl)piperazinyl-1-carboxamido; or

(10) Z ₂ and Z ₃ or Z ₃ and Z ₄ form a nitrogen- or oxygen-containing substituted or unsubstituted five-membered ring or six-membered ring, and the substituents can be selected from the same substituents as Z ₁ ;

其中A₁，A₂，A₃，A₄，A₅各自独立地选自：R2 is selected from:

wherein A ₁ , A ₂ , A ₃ , A ₄ , A ₅ are each independently selected from:

(1) hydrogen, fluorine, chlorine, bromine, iodine, cyano, trifluoromethyl, trifluoromethoxy, nitro,

(2) methylthio, ethylthio, isopropylthio, methylsulfinyl, ethylsulfinyl, isopropylsulfinyl, methylsulfonyl, ethylsulfonyl, isopropylsulfonyl, methanesulfonylamino , methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, tert-butoxycarbonyl, methylaminocarbonyl, ethylaminocarbonyl, propylamino Carbonyl, isopropylaminocarbonyl, cyclopropylaminocarbonyl, cyclobutylaminocarbonyl, cyclopentylaminocarbonyl, dimethylphosphinoyl, diethylphosphinoyl, diisopropylphosphinoyl.

In some embodiments, R1 is selected from:

其中Z₁，Z₂，Z₃，Z₄，Z₅各自独立地选自：

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from:

(1) Hydrogen,

(2) C1-C6 alkoxy

(3) piperidinyl, N-methyl-4-piperidinyl, 4-N,N-dimethylaminopiperidinyl, 4-N,N-diethylaminopiperidinyl, 4-N, N-diisopropylaminopiperidinyl, 4-hydroxypiperidinyl

(4) 4-(4-Methylpiperazinyl)piperidinyl, 4-(4-ethylpiperazinyl)piperidinyl, 4-(4-isopropylpiperazinyl)piperidinyl, 4 -(4-Acetylpiperazinyl)piperidinyl, 4-(4-tert-butoxycarbonylpiperazinyl)piperidinyl, 4-(4-methanesulfonylpiperazinyl)piperidinyl, 4-( 4-(2-Hydroxyethyl)piperazinyl)piperidinyl, 4-(4-(2-cyanoethyl)piperazinyl)piperidinyl, 4-(4-(3-hydroxypropyl) Piperazinyl) piperidinyl, 4-(4-(2-N,N-dimethylaminoethyl)piperazinyl)piperidinyl, 4-(4-(2-N,N-diethyl) Aminoethyl)piperazinyl)piperidinyl, 4-(4-(3-N,N-dimethylaminopropyl)piperazinyl)piperidinyl, 4-(4-(3-N,N -Diethylaminopropyl)piperazinyl)piperidinyl, 4-(tetrahydropyrrol-1-yl)piperidinyl, 4-(3-N,N-dimethylaminotetrahydropyrrolyl)piperidyl pyridyl,

(5) 4-methylpiperazinyl, 4-ethylpiperazinyl, 4-isopropylpiperazinyl, 4-acetylpiperazinyl, 4-tert-butoxycarbonylpiperazinyl, 4-methanesulfonic acid Acylpiperazinyl, 4-(2-hydroxyethyl)piperazinyl, 4-(2-cyanoethyl)piperazinyl, 4-(3-hydroxypropyl)piperazinyl, 4-(2- N,N-Dimethylaminoethyl)piperazinyl, 4-(2-N,N-diethylaminoethyl)piperazinyl, 4-(3-N,N-dimethylaminopropyl ) piperazinyl, 4-(3-N,N-diethylaminopropyl)piperazinyl, 4-(N-methyl-4-piperidinyl)piperazinyl, 4-(N-ethyl -4-Piperidinyl)piperazinyl or

(6) Z ₂ and Z ₃ or Z ₃ and Z ₄ form a nitrogen- or oxygen-containing substituted or unsubstituted five-membered ring, and the substituents can be selected from the same substituents as those of Z ₁ .

In some embodiments, R1 is selected from:

其中Z₁，Z₂，Z₃，Z₄，Z₅各自独立地选自：

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from:

(1) Hydrogen,

(2) Methoxy,

(3) 4-hydroxypiperidinyl, 4-(4-methylpiperazinyl) piperidinyl,

(4) 4-methylpiperazinyl, or

(5) Z ₂ and Z ₃ or Z ₃ and Z ₄ form

In some embodiments, R1 is selected from:

其中Z₁和Z₅二者之一为氢，另一为甲氧基；Z₄为氢；

Wherein one of Z ₁ and Z ₅ is hydrogen, the other is methoxy; Z ₄ is hydrogen;

Z ₃ is selected from: 4-hydroxypiperidinyl, 4-methylpiperazinyl, 4-(4-methylpiperazinyl)piperidinyl, or

Z ₂ forms with Z ₃

其中A₁，A₂，A₃，A₄，A₅各自独立地选自：In some embodiments, R2 is selected from:

wherein A ₁ , A ₂ , A ₃ , A ₄ , A ₅ are each independently selected from:

(1) hydrogen, (2) isopropylsulfonyl.

其中A₁和A₅二者之一为氢，另一为异丙基磺酰基；A₂，A₃，A₄都为氢。In some embodiments, R2 is selected from:

One of A ₁ and A ₅ is hydrogen, the other is isopropylsulfonyl; A ₂ , A ₃ and A ₄ are all hydrogen.

In a nineteenth aspect, the present invention provides a compound represented by the following general formula IT, its stereoisomer, its prodrug, its pharmaceutically acceptable salt or its pharmaceutically acceptable solvate,

Wherein, A is methylene; X is O;

R1 is selected from:

1) C1-C6 alkyl, 2-N,N-dimethylaminoethyl, 2-hydroxyethyl, 2-N,N-diethylaminoethyl, 2-N,N-diisopropyl Aminoethyl, 2-morpholinoethyl, 2-(4-methylpiperazinyl)ethyl, 3-N,N-dimethylaminopropyl, 3-N,N-diethylaminopropyl Base, 3-N,N-diisopropylaminopropyl, 3-morpholinylpropyl, 3-(4-methylpiperazinyl)propyl, C3-C6cycloalkyl, 4-N,N -Dimethylaminocyclohexyl, 4-N,N-diethylaminocyclohexyl, N-methyl-4-piperidinyl, N-ethyl-4-piperidinyl, N-isopropyl-4 -Piperidinyl, 1,3-dimethyl-5-pyrazolyl, 1-methyl-4-pyrazolyl, 3-methyl-5-isoxazolinyl, 1-(N-methyl -4-Piperidinyl)-4-pyrazolyl, 1-(N-tert-butoxycarbonyl-4-piperidinyl)-4-pyrazolyl;

其中Z₁，Z₂，Z₃，Z₄，Z₅各自独立地选自：2)

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from:

(1) hydrogen, fluorine, chlorine, bromine, iodine, nitro, cyano,

(2) C1-C6 alkyl, C1-C6 alkoxy, C1-C6 oxygen-containing alkyl, C1-C6 fluorine-containing alkyl, C1-C6 fluorine-containing alkoxy,

(3) piperidinyl, N-methyl-4-piperidinyl, 4-dimethylaminopiperidinyl, 4-N,N-diethylaminopiperidinyl, 4-N,N-diiso propylaminopiperidinyl, 4-hydroxypiperidinyl, 4-(4-methylpiperazinyl)piperidinyl, 4-(4-ethylpiperazinyl)piperidinyl, 4-(4-iso Propylpiperazinyl)piperidinyl, 4-(4-acetylpiperazinyl)piperidinyl, 4-(4-tert-butoxycarbonylpiperazinyl)piperidinyl, 4-(4-methanesulfonyl Piperazinyl)piperidyl, 4-(4-(2-hydroxyethyl)piperazinyl)piperidinyl, 4-(4-(2-cyanoethyl)piperazinyl)piperidinyl, 4 -(4-(3-Hydroxypropyl)piperazinyl)piperidinyl, 4-(4-(2-N,N-dimethylaminoethyl)piperazinyl)piperidinyl, 4-(4 -(2-N,N-Diethylaminoethyl)piperazinyl)piperidinyl, 4-(4-(3-N,N-dimethylaminopropyl)piperazinyl)piperidinyl, 4-(4-(3-N,N-Diethylaminopropyl)piperazinyl)piperidinyl, 4-(tetrahydropyrrolyl)piperidinyl, 4-(3-N,N-dimethyl ylaminotetrahydropyrrolyl)piperidinyl, 4-(tetrahydropyrrol-1-yl)piperidinyl

(4) 4-methylpiperazinyl, 4-ethylpiperazinyl, 4-isopropylpiperazinyl, 4-acetylpiperazinyl, 4-tert-butoxycarbonylpiperazinyl, 4-methanesulfonic acid Acylpiperazinyl, 4-(2-hydroxyethyl)piperazinyl, 4-(2-cyanoethyl)piperazinyl, 4-(3-hydroxypropyl)piperazinyl, 4-(2- N,N-Dimethylaminoethyl)piperazinyl, 4-(2-N,N-diethylaminoethyl)piperazinyl, 4-(3-N,N-dimethylaminopropyl ) piperazinyl, 4-(3-N,N-diethylaminopropyl)piperazinyl, 4-(N-methyl-4-piperidinyl)piperazinyl, 4-(N-ethyl -4-Piperidinyl)piperazinyl,

(5) N,N-dimethylamino, N,N-diethylamino, N,N-diisopropylamino, 2-N,N-dimethylaminoethylamino, 2-morpholino Ethylamino, 2-(4-methylpiperazinyl)ethylamino, 3-N,N-dimethylaminopropylamino, 3-N,N-diethylaminopropylamino, 3-N ,N-diisopropylaminopropylamino, 3-morpholinopropylamino, 3-(4-methylpiperazinyl)propylamino, N-methylpiperidine-4-amino, N-ethyl piperidine-4-amino, N-isopropylpiperidine-4-amino,

(6) 2-N,N-dimethylaminoethoxy, 2-N,N-diethylaminoethoxy, 2-N,N-diisopropylaminoethoxy, 2-(4 -Methylpiperazinyl)ethoxy, 2-(4-acetylpiperazinyl)ethoxy, 2-morpholinylethoxy, 2-thiophenarinylethoxy, 2-piperidinyl Ethoxy, 3-N,N-dimethylaminopropoxy, 3-N,N-diethylaminopropoxy, 3-N,N-diisopropylaminopropoxy, 3-( 4-Methylpiperazinyl)propoxy, 3-(4-Acetylpiperazinyl)propoxy, 3-morpholinopropoxy, 3-thiophenarinylpropoxy, 3-piperidine pyridin-2-ylmethoxy, pyridin-3-ylmethoxy, pyridin-4-ylmethoxy, phenylmethoxy, monohalogen substituted phenylmethoxy, geminal dihalogen Substituted phenylmethoxy, heterodihalogen substituted phenylmethoxy,

(7) Hydroxysulfonyl, aminosulfonyl, methylaminosulfonyl, ethylaminosulfonyl, propylaminosulfonyl, isopropylaminosulfonyl, cyclopropylaminosulfonyl, cyclobutylaminosulfonyl, cyclopentylamino Sulfonyl, piperidin-1-ylsulfonyl, 4-hydroxypiperidin-1-ylsulfonyl, 4-N,N-dimethylaminopiperidin-1-ylsulfonyl, 4-N,N-di Ethylaminopiperidin-1-ylsulfonyl, tetrahydropyrrolyl-1-sulfonyl, 3-N,N-dimethylaminotetrahydropyrrolyl-1-sulfonyl, 3-N,N-diethyl ylaminotetrahydropyrrolyl-1-sulfonyl, 4-methylpiperazin-1-ylsulfonyl, 4-ethylpiperazinyl-1-sulfonyl, 4-acetylpiperazinyl-1-sulfonyl , 4-tert-butoxycarbonylpiperazinyl-1-sulfonyl, 4-(2-hydroxyethyl)piperazinyl-1-sulfonyl, 4-(2-cyanoethyl)piperazinyl-1- Sulfonyl, 4-(2-N,N-dimethylaminoethyl)piperazinyl-1-sulfonyl, 4-(2-N,N-diethylethyl)piperazinyl-1-sulfonyl Acyl, 4-(3-hydroxypropyl)piperazinyl-1-sulfonyl, 4-(3-N,N-dimethylaminopropyl)piperazinyl-1-sulfonyl, 4-(3- N,N-Diethylaminopropyl)piperazinyl-1-sulfonyl, morpholinyl-1-sulfonyl, 3,5-dimethylmorpholinyl-1-sulfonyl, 4-(4- Methyl-piperazin-1-yl)piperidin-1-ylsulfonyl, 4-(4-ethyl-1-piperazinyl)piperidin-1-ylsulfonyl, 4-(4-acetyl- 1-Piperazinyl)piperidin-1-ylsulfonyl, 4-(N-methyl-4-piperidinyl)piperazinyl-1-sulfonyl,

(8) Hydroxycarbonyl, aminocarbonyl, methylaminocarbonyl, ethylaminocarbonyl, propylaminocarbonyl, isopropylaminocarbonyl, cyclopropylaminocarbonyl, cyclobutylaminocarbonyl, cyclopentylaminocarbonyl, piperidinyl-1- Carbonyl, 4-hydroxypiperidinyl-1-carbonyl, 4-N,N-dimethylaminopiperidinyl-1-carbonyl, 4-N,N-diethylaminopiperidinyl-1-carbonyl, tetra Hydropyrrolyl-1-carbonyl, 3-N,N-dimethylaminotetrahydropyrrolyl-1-carbonyl, 3-N,N-diethylaminotetrahydropyrrolyl-1-carbonyl, 4-methyl Piperazin-1-ylcarbonyl, 4-ethylpiperazinyl-1-carbonyl, 4-acetylpiperazinyl-1-carbonyl, 4-tert-butoxycarbonylpiperazinyl-1-carbonyl, 4-(2 -Hydroxyethyl)piperazinyl-1-carbonyl, 4-(2-cyanoethyl)piperazinyl-1-carbonyl, 4-(2-N,N-dimethylaminoethyl)piperazinyl -1-carbonyl, 4-(2-N,N-diethylaminoethyl)piperazinyl-1-carbonyl, 4-(3-hydroxypropyl)piperazinyl-1-carbonyl, 4-(3 -N,N-Dimethylaminopropyl)piperazinyl-1-carbonyl, 4-(3-N,N-diethylaminopropyl)piperazinyl-1-carbonyl, morpholinyl-1- Carbonyl, 3,5-dimethylmorpholinyl-1-carbonyl, 4-(4-methyl-piperazin-1-yl)piperidin-1-ylcarbonyl, 4-(4-ethyl-1- Piperazinyl)piperidinyl-1-carbonyl, 4-(4-acetyl-1-piperazinyl)piperidinyl-1-carbonyl, 4-(N-methyl-4-piperidinyl)piperazine yl-1-carbonyl, methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, tert-butoxycarbonyl,

(9) carbamoylamino, methylcarbamoylamino, ethylcarbamoylamino, propylcarbamoylamino, isopropylcarbamoylamino, cyclopropylcarbamoylamino, cyclobutylcarbamoylamino, cyclo Amylcarbamoylamino, piperidinyl-1-carboxamido, 4-hydroxypiperidinyl-1-carboxamido, 4-N,N-dimethylaminopiperidinyl-1-carboxamido, 4-N,N-Diethylaminopiperidinyl-1-carboxamido, tetrahydropyrrolyl-1-carboxamido, 3-N,N-dimethylaminotetrahydropyrrolyl-1-carboxyl Amino, 3-N,N-diethylaminotetrahydropyrrolyl-1-carboxamido, 4-methylpiperazinyl-1-carboxamido, 4-ethylpiperazinyl-1-carboxamido , 4-Acetyl piperazinyl-1-carboxamido, 4-tert-butoxycarbonyl piperazinyl-1-carboxamido, 4-(2-hydroxyethyl) piperazinyl-1-carboxamido, 4-(2-cyanoethyl)piperazinyl-1-carboxamido, 4-(2-N,N-dimethylaminoethyl)piperazinyl-1-carboxamido, 4-(2 -N,N-Diethylaminoethyl)piperazinyl-1-carboxamido, 4-(3-hydroxypropyl)piperazinyl-1-carboxamido, 4-(3-N,N- Dimethylaminopropyl)piperazinyl-1-carboxamido, 4-(3-N,N-diethylaminopropyl)piperazinyl-1-carboxamido, morpholino-1-methyl amido, 3,5-dimethylmorpholino-1-carboxamido, 4-(4-methyl-piperazin-1-yl)piperidinyl-1-carboxamido, 4-(4- Ethyl-1-piperazinyl)piperidinyl-1-carboxamido, 4-(4-acetyl-1-piperazinyl)piperidinyl-1-carboxamido, 4-(N-methyl -4-Piperidinyl)piperazinyl-1-carboxamido; or

(10) Z ₂ and Z ₃ or Z ₃ and Z ₄ form a nitrogen- or oxygen-containing substituted or unsubstituted five-membered ring or six-membered ring, and the substituents can be selected from the same substituents as Z ₁ ;

其中A₁，A₂，A₃，A₄，A₅各自独立地选自：R2 is selected from

wherein A ₁ , A ₂ , A ₃ , A ₄ , A ₅ are each independently selected from:

(1) hydrogen, fluorine, chlorine, bromine, iodine, cyano, trifluoromethyl, trifluoromethoxy, nitro,

(2) Methylthio, ethylthio, isopropylthio, methylsulfinyl, ethylsulfinyl, isopropylsulfinyl, methylsulfonyl, ethylsulfonyl, isopropylsulfonyl, tert-butanesulfonyl , methanesulfonylamino, methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, tert-butoxycarbonyl, methylaminocarbonyl, ethyl Aminocarbonyl, propylaminocarbonyl, isopropylaminocarbonyl, dimethylaminocarbonyl, cyclopropylaminocarbonyl, cyclobutylaminocarbonyl, cyclopentylaminocarbonyl, dimethylphosphinoyl, diethylphosphinoyl, diethylaminocarbonyl Isopropylphosphinoyl.

其中Z₁，Z₂，Z₃，Z₄，Z₅各自独立地选自：In some embodiments, R1 is selected from

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from:

(1) Hydrogen,

(2) C1-C6 alkoxy,

(3) piperidinyl, N-methyl-4-piperidinyl, 4--dimethylaminopiperidinyl, 4-N,N-diethylaminopiperidinyl, 4-N,N-diethylaminopiperidinyl Isopropylaminopiperidinyl, 4-hydroxypiperidinyl, 4-(4-methylpiperazinyl)piperidinyl, 4-(4-ethylpiperazinyl)piperidinyl, 4-(4- Isopropylpiperazinyl)piperidinyl, 4-(4-acetylpiperazinyl)piperidinyl, 4-(4-tert-butoxycarbonylpiperazinyl)piperidinyl, 4-(4-methanesulfonyl) acylpiperazinyl)piperidyl, 4-(4-(2-hydroxyethyl)piperazinyl)piperidinyl, 4-(4-(2-cyanoethyl)piperazinyl)piperidinyl, 4-(4-(3-Hydroxypropyl)piperazinyl)piperidinyl, 4-(4-(2-N,N-dimethylaminoethyl)piperazinyl)piperidinyl, 4-( 4-(2-N,N-Diethylaminoethyl)piperazinyl)piperidinyl, 4-(4-(3-N,N-dimethylaminopropyl)piperazinyl)piperidinyl , 4-(4-(3-N,N-diethylaminopropyl)piperazinyl)piperidinyl, 4-(tetrahydropyrrolyl)piperidinyl, 4-(3-N,N-di Methylaminotetrahydropyrrolyl)piperidinyl, 4-(tetrahydropyrrol-1-yl)piperidinyl;

(4) 4-methylpiperazinyl, 4-ethylpiperazinyl, 4-isopropylpiperazinyl, 4-acetylpiperazinyl, 4-tert-butoxycarbonylpiperazinyl, 4-methanesulfonic acid Acylpiperazinyl, 4-(2-hydroxyethyl)piperazinyl, 4-(2-cyanoethyl)piperazinyl, 4-(3-hydroxypropyl)piperazinyl, 4-(2- N,N-Dimethylaminoethyl)piperazinyl, 4-(2-N,N-diethylaminoethyl)piperazinyl, 4-(3-N,N-dimethylaminopropyl ) piperazinyl, 4-(3-N,N-diethylaminopropyl)piperazinyl, 4-(N-methyl-4-piperidinyl)piperazinyl, 4-(N-ethyl -4-Piperidinyl)piperazinyl or

(5) Z ₂ and Z ₃ or Z ₃ and Z ₄ form a nitrogen- or oxygen-containing substituted or unsubstituted five-membered ring, and the substituents may be selected from the same substituents as those of Z ₁ .

其中Z₁，Z₂，Z₃，Z₄，Z₅各自独立地任选自：In some embodiments, R1 is selected from:

Wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from:

(1) Hydrogen,

(2) C1-C6 alkoxy,

(3) 4-methylpiperazinyl, 4-(4-methylpiperazinyl) piperidinyl, morpholinyl, 4-dimethylamino-piperidinyl,

(4) Z ₂ and Z ₃ can form a nitrogen-containing substituted or unsubstituted five-membered ring

其中In some embodiments, R1 is selected from:

in

One of Z ₁ and Z ₅ is hydrogen, and the other is methoxy;

Z ₃ is selected from: 4-dimethylamino-piperidinyl, 4-methylpiperazinyl, 4-(4-methylpiperazinyl)piperidinyl, 4-methylpiperazinyl or morpholinyl, or

Z ₂ and Z ₃ or Z ₃ and Z ₄ form

其中A₁，A₂，A₃，A₄，A₅各自独立地任选自：In some embodiments, R2 is selected from:

Wherein A ₁ , A ₂ , A ₃ , A ₄ , A ₅ are each independently selected from:

(1) Hydrogen

(2) Isopropylsulfonyl.

其中A₁和A₅二者之一为氢，另一为异丙基磺酰基；A₂，A₃，A₄都为氢。In some embodiments, R2 is selected from:

One of A ₁ and A ₅ is hydrogen, the other is isopropylsulfonyl; A ₂ , A ₃ and A ₄ are all hydrogen.

In a twentieth aspect, the present invention provides a compound represented by the following general formula IN, its stereoisomer, its prodrug, its pharmaceutically acceptable salt or its pharmaceutically acceptable solvate,

where R1 is selected from:

1) propylaminoethyl, 2-morpholinoethyl, 2-(4-methylpiperazinyl)ethyl, 3-N,N-dimethylaminopropyl, 3-N,N-di Ethylaminopropyl, 3-N,N-diisopropylaminopropyl, 3-morpholinylpropyl, 3-(4-methylpiperazinyl)propyl, C3-C6 cycloalkyl, 4 -N,N-Dimethylaminocyclohexyl, 4-N,N-diethylaminocyclohexyl, N-methyl-4-piperidinyl, N-ethyl-4-piperidinyl, N-iso Propyl-4-piperidinyl, 1,3-dimethyl-5-pyrazolyl, 1-methyl-4-pyrazolyl, 3-methyl-5-isoxazolinyl, 1-( N-methyl-4-piperidinyl)-4-pyrazolyl, 1-(N-tert-butoxycarbonyl-4-piperidinyl)-4-pyrazolyl;

其中Z₁，Z₂，Z₃，Z₄，Z₅各自独立地选自：2)

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from:

(1) hydrogen, fluorine, chlorine, bromine, iodine, nitro, cyano,

(2) C1-C6 alkyl, C1-C6 alkoxy, C1-C6 oxygen-containing alkyl, C1-C6 fluorine-containing alkyl, C1-C6 fluorine-containing alkoxy,

(3) piperidinyl, N-methyl-4-piperidinyl, 4-N,N-dimethylaminopiperidinyl, 4-N,N-diethylaminopiperidinyl, 4-N, N-diisopropylaminopiperidinyl, 4-hydroxypiperidinyl, 4-(4-methylpiperazinyl)piperidinyl, 4-(4-ethylpiperazinyl)piperidinyl, 4- (4-Isopropylpiperazinyl)piperidinyl, 4-(4-acetylpiperazinyl)piperidinyl, 4-(4-tert-butoxycarbonylpiperazinyl)piperidinyl, 4-(4 -Methylsulfonylpiperazinyl)piperidyl, 4-(4-(2-hydroxyethyl)piperazinyl)piperidyl, 4-(4-(2-cyanoethyl)piperazinyl)piperidyl pyridyl, 4-(4-(3-hydroxypropyl)piperazinyl)piperidinyl, 4-(4-(2-N,N-dimethylaminoethyl)piperazinyl)piperidinyl, 4-(4-(2-N,N-Diethylaminoethyl)piperazinyl)piperidyl, 4-(4-(3-N,N-dimethylaminopropyl)piperazinyl) piperidinyl, 4-(4-(3-N,N-diethylaminopropyl)piperazinyl)piperidinyl, 4-(tetrahydropyrrolyl)piperidinyl, 4-(3-N, N-dimethylaminotetrahydropyrrolyl) piperidinyl,

(4) 4-methylpiperazinyl, 4-ethylpiperazinyl, 4-isopropylpiperazinyl, 4-acetylpiperazinyl, 4-tert-butoxycarbonylpiperazinyl, 4-methanesulfonic acid Acylpiperazinyl, 4-(2-hydroxyethyl)piperazinyl, 4-(2-cyanoethyl)piperazinyl, 4-(3-hydroxypropyl)piperazinyl, 4-(2- N,N-Dimethylaminoethyl)piperazinyl, 4-(2-N,N-diethylaminoethyl)piperazinyl, 4-(3-N,N-dimethylaminopropyl ) piperazinyl, 4-(3-N,N-diethylaminopropyl)piperazinyl, 4-(N-methyl-4-piperidinyl)piperazinyl, 4-(N-ethyl -4-Piperidinyl)piperazinyl,

(5) N,N-dimethylamino, N,N-diethylamino, N,N-diisopropylamino, 2-N,N-dimethylaminoethylamino, 2-morpholino Ethylamino, 2-(4-methylpiperazinyl)ethylamino, 3-N,N-dimethylaminopropylamino, 3-N,N-diethylaminopropylamino, 3-N ,N-diisopropylaminopropylamino, 3-morpholinopropylamino, 3-(4-methylpiperazinyl)propylamino, N-methylpiperidine-4-amino, N-ethyl piperidine-4-amino, N-isopropylpiperidine-4-amino,

(6) 2-N,N-dimethylaminoethoxy, 2-N,N-diethylaminoethoxy, 2-N,N-diisopropylaminoethoxy, 2-(4 -Methylpiperazinyl)ethoxy, 2-(4-acetylpiperazinyl)ethoxy, 2-morpholinylethoxy, 2-thiophenarinylethoxy, 2-piperidinyl Ethoxy, 3-N,N-dimethylaminopropoxy, 3-N,N-diethylaminopropoxy, 3-N,N-diisopropylaminopropoxy, 3-( 4-Methylpiperazinyl)propoxy, 3-(4-Acetylpiperazinyl)propoxy, 3-morpholinopropoxy, 3-thiophenarinylpropoxy, 3-piperidine pyridin-2-ylmethoxy, pyridin-3-ylmethoxy, pyridin-4-ylmethoxy, phenylmethoxy, monohalogen substituted phenylmethoxy, geminal dihalogen Substituted phenylmethoxy, heterodihalogen substituted phenylmethoxy,

(7) Hydroxysulfonyl, aminosulfonyl, methylaminosulfonyl, ethylaminosulfonyl, propylaminosulfonyl, isopropylaminosulfonyl, cyclopropylaminosulfonyl, cyclobutylaminosulfonyl, cyclopentylamino Sulfonyl, piperidin-1-ylsulfonyl, 4-hydroxypiperidin-1-ylsulfonyl, 4-N,N-dimethylaminopiperidin-1-ylsulfonyl, 4-N,N-di Ethylaminopiperidin-1-ylsulfonyl, tetrahydropyrrolyl-1-sulfonyl, 3-N,N-dimethylaminotetrahydropyrrolyl-1-sulfonyl, 3-N,N-diethyl ylaminotetrahydropyrrolyl-1-sulfonyl, 4-methylpiperazin-1-ylsulfonyl, 4-ethylpiperazinyl-1-sulfonyl, 4-acetylpiperazinyl-1-sulfonyl , 4-tert-butoxycarbonylpiperazinyl-1-sulfonyl, 4-(2-hydroxyethyl)piperazinyl-1-sulfonyl, 4-(2-cyanoethyl)piperazinyl-1- Sulfonyl, 4-(2-N,N-dimethylaminoethyl)piperazinyl-1-sulfonyl, 4-(2-N,N-diethylethyl)piperazinyl-1-sulfonyl Acyl, 4-(3-hydroxypropyl)piperazinyl-1-sulfonyl, 4-(3-N,N-dimethylaminopropyl)piperazinyl-1-sulfonyl, 4-(3- N,N-Diethylaminopropyl)piperazinyl-1-sulfonyl, morpholinyl-1-sulfonyl, 3,5-dimethylmorpholinyl-1-sulfonyl, 4-(4- Methyl-piperazin-1-yl)piperidin-1-ylsulfonyl, 4-(4-ethyl-1-piperazinyl)piperidin-1-ylsulfonyl, 4-(4-acetyl- 1-Piperazinyl)piperidin-1-ylsulfonyl, 4-(N-methyl-4-piperidinyl)piperazinyl-1-sulfonyl,

(8) Hydroxycarbonyl, aminocarbonyl, methylaminocarbonyl, ethylaminocarbonyl, propylaminocarbonyl, isopropylaminocarbonyl, cyclopropylaminocarbonyl, cyclobutylaminocarbonyl, cyclopentylaminocarbonyl, piperidinyl-1- Carbonyl, 4-hydroxypiperidinyl-1-carbonyl, 4-N,N-dimethylaminopiperidinyl-1-carbonyl, 4-N,N-diethylaminopiperidinyl-1-carbonyl, tetra Hydropyrrolyl-1-carbonyl, 3-N,N-dimethylaminotetrahydropyrrolyl-1-carbonyl, 3-N,N-diethylaminotetrahydropyrrolyl-1-carbonyl, 4-methyl Piperazin-1-ylcarbonyl, 4-ethylpiperazinyl-1-carbonyl, 4-acetylpiperazinyl-1-carbonyl, 4-tert-butoxycarbonylpiperazinyl-1-carbonyl, 4-(2 -Hydroxyethyl)piperazinyl-1-carbonyl, 4-(2-cyanoethyl)piperazinyl-1-carbonyl, 4-(2-N,N-dimethylaminoethyl)piperazinyl -1-carbonyl, 4-(2-N,N-diethylaminoethyl)piperazinyl-1-carbonyl, 4-(3-hydroxypropyl)piperazinyl-1-carbonyl, 4-(3 -N,N-Dimethylaminopropyl)piperazinyl-1-carbonyl, 4-(3-N,N-diethylaminopropyl)piperazinyl-1-carbonyl, morpholinyl-1- Carbonyl, 3,5-dimethylmorpholinyl-1-carbonyl, 4-(4-methyl-piperazin-1-yl)piperidin-1-ylcarbonyl, 4-(4-ethyl-1- Piperazinyl)piperidinyl-1-carbonyl, 4-(4-acetyl-1-piperazinyl)piperidinyl-1-carbonyl, 4-(N-methyl-4-piperidinyl)piperazine yl-1-carbonyl, methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, tert-butoxycarbonyl,

(9) carbamoylamino, methylcarbamoylamino, ethylcarbamoylamino, propylcarbamoylamino, isopropylcarbamoylamino, cyclopropylcarbamoylamino, cyclobutylcarbamoylamino, cyclo Amylcarbamoylamino, piperidinyl-1-carboxamido, 4-hydroxypiperidinyl-1-carboxamido, 4-N,N-dimethylaminopiperidinyl-1-carboxamido, 4-N,N-Diethylaminopiperidinyl-1-carboxamido, tetrahydropyrrolyl-1-carboxamido, 3-N,N-dimethylaminotetrahydropyrrolyl-1-carboxyl Amino, 3-N,N-diethylaminotetrahydropyrrolyl-1-carboxamido, 4-methylpiperazinyl-1-carboxamido, 4-ethylpiperazinyl-1-carboxamido , 4-Acetyl piperazinyl-1-carboxamido, 4-tert-butoxycarbonyl piperazinyl-1-carboxamido, 4-(2-hydroxyethyl) piperazinyl-1-carboxamido, 4-(2-cyanoethyl)piperazinyl-1-carboxamido, 4-(2-N,N-dimethylaminoethyl)piperazinyl-1-carboxamido, 4-(2 -N,N-Diethylaminoethyl)piperazinyl-1-carboxamido, 4-(3-hydroxypropyl)piperazinyl-1-carboxamido, 4-(3-N,N- Dimethylaminopropyl)piperazinyl-1-carboxamido, 4-(3-N,N-diethylaminopropyl)piperazinyl-1-carboxamido, morpholino-1-methyl amido, 3,5-dimethylmorpholino-1-carboxamido, 4-(4-methyl-piperazin-1-yl)piperidinyl-1-carboxamido, 4-(4- Ethyl-1-piperazinyl)piperidinyl-1-carboxamido, 4-(4-acetyl-1-piperazinyl)piperidinyl-1-carboxamido, 4-(N-methyl -4-Piperidinyl)piperazinyl-1-carboxamido; or

(10) Z ₂ and Z ₃ or Z ₃ and Z ₄ form a nitrogen- or oxygen-containing substituted or unsubstituted five-membered ring or six-membered ring, and the substituents can be selected from the same substituents as Z ₁ ;

其中A₁，A₂，A₃，A₄，A₅各自独立地选自：R2 is selected from

wherein A ₁ , A ₂ , A ₃ , A ₄ , A ₅ are each independently selected from:

(1) hydrogen, fluorine, chlorine, bromine, iodine, cyano, trifluoromethyl, trifluoromethoxy, nitro,

(2) methylthio, ethylthio, isopropylthio, methylsulfinyl, ethylsulfinyl, isopropylsulfinyl, methylsulfonyl, ethylsulfonyl, isopropylsulfonyl, methanesulfonylamino , methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, tert-butoxycarbonyl, methylaminocarbonyl, ethylaminocarbonyl, propylamino Carbonyl, isopropylaminocarbonyl, cyclopropylaminocarbonyl, cyclobutylaminocarbonyl, cyclopentylaminocarbonyl, dimethylphosphinoyl, diethylphosphinoyl, diisopropylphosphinoyl.

其中Z₁，Z₂，Z₃，Z₄，Z₅各自独立地选自：In some embodiments, R1 is selected from:

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from:

(1) Hydrogen,

(2) C1-C6 alkyl,

(3) C1-C6 alkoxy,

(4) piperidinyl, N-methyl-4-piperidinyl, 4-N,N-dimethylaminopiperidinyl, 4-N,N-diethylaminopiperidinyl, 4-N, N-diisopropylaminopiperidinyl, 4-hydroxypiperidinyl

(5) 4-(4-Methylpiperazinyl)piperidinyl, 4-(4-ethylpiperazinyl)piperidinyl, 4-(4-isopropylpiperazinyl)piperidinyl, 4 -(4-Acetylpiperazinyl)piperidinyl, 4-(4-tert-butoxycarbonylpiperazinyl)piperidinyl, 4-(4-methanesulfonylpiperazinyl)piperidinyl, 4-( 4-(2-Hydroxyethyl)piperazinyl)piperidinyl, 4-(4-(2-cyanoethyl)piperazinyl)piperidinyl, 4-(4-(3-hydroxypropyl) Piperazinyl) piperidinyl, 4-(4-(2-N,N-dimethylaminoethyl)piperazinyl)piperidinyl, 4-(4-(2-N,N-diethyl) Aminoethyl)piperazinyl)piperidinyl, 4-(4-(3-N,N-dimethylaminopropyl)piperazinyl)piperidinyl, 4-(4-(3-N,N -Diethylaminopropyl)piperazinyl)piperidinyl, 4-(tetrahydropyrrolyl)piperidinyl, 4-(3-N,N-dimethylaminotetrahydropyrrolyl)piperidinyl,

(6) 4-methylpiperazinyl, 4-ethylpiperazinyl, 4-isopropylpiperazinyl, 4-acetylpiperazinyl, 4-tert-butoxycarbonylpiperazinyl, 4-methanesulfonic acid Acylpiperazinyl, 4-(2-hydroxyethyl)piperazinyl, 4-(2-cyanoethyl)piperazinyl, 4-(3-hydroxypropyl)piperazinyl, 4-(2- N,N-Dimethylaminoethyl)piperazinyl, 4-(2-N,N-diethylaminoethyl)piperazinyl, 4-(3-N,N-dimethylaminopropyl ) piperazinyl, 4-(3-N,N-diethylaminopropyl)piperazinyl, 4-(N-methyl-4-piperidinyl)piperazinyl, 4-(N-ethyl -4-Piperidinyl)piperazinyl,

(7) Hydroxysulfonyl, aminosulfonyl, methylaminosulfonyl, ethylaminosulfonyl, propylaminosulfonyl, isopropylaminosulfonyl, cyclopropylaminosulfonyl, cyclobutylaminosulfonyl, cyclopentylamino Sulfonyl, piperidin-1-ylsulfonyl, 4-hydroxypiperidin-1-ylsulfonyl, 4-N,N-dimethylaminopiperidin-1-ylsulfonyl, 4-N,N-di Ethylaminopiperidin-1-ylsulfonyl, tetrahydropyrrolyl-1-sulfonyl, 3-N,N-dimethylaminotetrahydropyrrolyl-1-sulfonyl, 3-N,N-diethyl ylaminotetrahydropyrrolyl-1-sulfonyl, 4-methylpiperazin-1-ylsulfonyl, 4-ethylpiperazinyl-1-sulfonyl, 4-acetylpiperazinyl-1-sulfonyl , 4-tert-butoxycarbonylpiperazinyl-1-sulfonyl, 4-(2-hydroxyethyl)piperazinyl-1-sulfonyl, 4-(2-cyanoethyl)piperazinyl-1- Sulfonyl, 4-(2-N,N-dimethylaminoethyl)piperazinyl-1-sulfonyl, 4-(2-N,N-diethylethyl)piperazinyl-1-sulfonyl Acyl, 4-(3-hydroxypropyl)piperazinyl-1-sulfonyl, 4-(3-N,N-dimethylaminopropyl)piperazinyl-1-sulfonyl, 4-(3- N,N-Diethylaminopropyl)piperazinyl-1-sulfonyl, morpholinyl-1-sulfonyl, 3,5-dimethylmorpholinyl-1-sulfonyl, 4-(4- Methyl-piperazin-1-yl)piperidin-1-ylsulfonyl, 4-(4-ethyl-1-piperazinyl)piperidin-1-ylsulfonyl, 4-(4-acetyl- 1-Piperazinyl)piperidin-1-ylsulfonyl, 4-(N-methyl-4-piperidinyl)piperazinyl-1-sulfonyl, or

(8) Z ₂ and Z ₃ or Z ₃ and Z ₄ form a nitrogen- or oxygen-containing substituted or unsubstituted five- or six-membered ring, and the substituents can be selected from the same substituents as those of Z ₁ .

其中Z₁，Z₂，Z₃，Z₄，Z₅各自独立地选自：In some embodiments, R1 is selected from:

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from:

(1) Hydrogen,

(2) methyl, methoxy,

(3) 4-hydroxypiperidinyl, 4-methylpiperazinyl, N-methyl-4-piperidinyl,

(4) 4-(4-Methylpiperazinyl)piperidinyl, 4-(tetrahydropyrrol-1-yl)piperidinyl, aminosulfonyl, or

(5) Z ₂ and Z ₃ or Z ₃ and Z ₄ form

In some embodiments, R1 is selected from:

其中Z₁和Z₅二者之一为氢，另一为甲氧基；

Wherein one of Z ₁ and Z ₅ is hydrogen, and the other is methoxy;

One of Z ₂ and Z ₄ is hydrogen, the other is methyl,

Z ₃ is selected from: 4-hydroxypiperidinyl, 4-methylpiperazinyl, N-methyl-4-piperidinyl, 4-(4-methylpiperazinyl)piperidinyl, 4-(tetrakis Hydropyrrol-1-yl)piperidinyl, aminosulfonyl, or

Z ₂ and Z ₃ or Z ₃ and Z ₄ form

其中A₁，A₂，A₃，A₄，A₅各自独立地选自：In some embodiments, R2 is selected from:

wherein A ₁ , A ₂ , A ₃ , A ₄ , A ₅ are each independently selected from:

(1) hydrogen, fluorine, chlorine, bromine, iodine, cyano, trifluoromethyl, trifluoromethoxy, nitro,

(2) Methylthio, ethylthio, methanesulfinyl, ethylsulfinyl, methanesulfonyl, ethanesulfonyl, methanesulfonylamino, methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, iso Propoxycarbonyl, n-butoxycarbonyl, methylaminocarbonyl, ethylaminocarbonyl, propylaminocarbonyl, cyclopropylaminocarbonyl, cyclobutylaminocarbonyl, cyclopentylaminocarbonyl, dimethylphosphinoyl.

其中A₁，A₂，A₃，A₄，A₅各自独立地选自：In some embodiments, R2 is selected from:

wherein A ₁ , A ₂ , A ₃ , A ₄ , A ₅ are each independently selected from:

(1) Hydrogen, (2) Methoxycarbonyl.

其中A₁和A₅二者之一为氢，另一为甲氧羰基；A₂，A₃，A₄都为氢。In some embodiments, R2 is selected from:

One of A ₁ and A ₅ is hydrogen, and the other is methoxycarbonyl; A ₂ , A ₃ and A ₄ are all hydrogen.

In a twenty-first aspect, the present invention provides a compound represented by the following general formula IU, its stereoisomer, its prodrug, its pharmaceutically acceptable salt or its pharmaceutically acceptable solvate,

where R1 is selected from:

1) C1-C6 alkyl, 2-N,N-dimethylaminoethyl, 2-hydroxyethyl, 2-N,N-diethylaminoethyl, 2-N,N-diisopropyl Aminoethyl, 2-morpholinoethyl, 2-(4-methylpiperazinyl)ethyl, 3-N,N-dimethylaminopropyl, 3-N,N-diethylaminopropyl Base, 3-N,N-diisopropylaminopropyl, 3-morpholinylpropyl, 3-(4-methylpiperazinyl)propyl, C3-C6cycloalkyl, 4-N,N -Dimethylaminocyclohexyl, 4-N,N-diethylaminocyclohexyl, N-methyl-4-piperidinyl, N-ethyl-4-piperidinyl, N-isopropyl-4 -Piperidinyl, 1,3-dimethyl-5-pyrazolyl, 1-methyl-4-pyrazolyl, 3-methyl-5-isoxazolinyl, 1-(N-methyl -4-Piperidinyl)-4-pyrazolyl, 1-(N-tert-butoxycarbonyl-4-piperidinyl)-4-pyrazolyl;

其中Z₁，Z₂，Z₃，Z₄，Z₅各自独立地选自：2)

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from:

(1) hydrogen, fluorine, chlorine, bromine, iodine, nitro, cyano,

(2) C1-C6 alkyl, C1-C6 alkoxy, C1-C6 oxygen-containing alkyl, C1-C6 fluorine-containing alkyl, C1-C6 fluorine-containing alkoxy,

(3) piperidinyl, N-methyl-4-piperidinyl, 4-N,N-dimethylaminopiperidinyl, 4-N,N-diethylaminopiperidinyl, 4-N, N-diisopropylaminopiperidinyl, 4-hydroxypiperidinyl, 4-(4-methylpiperazinyl)piperidinyl, 4-(4-ethylpiperazinyl)piperidinyl, 4- (4-Isopropylpiperazinyl)piperidinyl, 4-(4-acetylpiperazinyl)piperidinyl, 4-(4-tert-butoxycarbonylpiperazinyl)piperidinyl, 4-(4 -Methylsulfonylpiperazinyl)piperidyl, 4-(4-(2-hydroxyethyl)piperazinyl)piperidyl, 4-(4-(2-cyanoethyl)piperazinyl)piperidyl pyridyl, 4-(4-(3-hydroxypropyl)piperazinyl)piperidinyl, 4-(4-(2-N,N-dimethylaminoethyl)piperazinyl)piperidinyl, 4-(4-(2-N,N-Diethylaminoethyl)piperazinyl)piperidyl, 4-(4-(3-N,N-dimethylaminopropyl)piperazinyl) piperidinyl, 4-(4-(3-N,N-diethylaminopropyl)piperazinyl)piperidinyl, 4-(tetrahydropyrrolyl)piperidinyl, 4-(3-N, N-dimethylaminotetrahydropyrrolyl) piperidinyl,

(4) 4-methylpiperazinyl, 4-ethylpiperazinyl, 4-isopropylpiperazinyl, 4-acetylpiperazinyl, 4-tert-butoxycarbonylpiperazinyl, 4-methanesulfonic acid Acylpiperazinyl, 4-(2-hydroxyethyl)piperazinyl, 4-(2-cyanoethyl)piperazinyl, 4-(3-hydroxypropyl)piperazinyl, 4-(2- N,N-Dimethylaminoethyl)piperazinyl, 4-(2-N,N-diethylaminoethyl)piperazinyl, 4-(3-N,N-dimethylaminopropyl ) piperazinyl, 4-(3-N,N-diethylaminopropyl)piperazinyl, 4-(N-methyl-4-piperidinyl)piperazinyl, 4-(N-ethyl -4-Piperidinyl)piperazinyl,

(5) N,N-dimethylamino, N,N-diethylamino, N,N-diisopropylamino, 2-N,N-dimethylaminoethylamino, 2-morpholino Ethylamino, 2-(4-methylpiperazinyl)ethylamino, 3-N,N-dimethylaminopropylamino, 3-N,N-diethylaminopropylamino, 3-N ,N-diisopropylaminopropylamino, 3-morpholinopropylamino, 3-(4-methylpiperazinyl)propylamino, N-methylpiperidine-4-amino, N-ethyl piperidine-4-amino, N-isopropylpiperidine-4-amino,

(6) 2-N,N-dimethylaminoethoxy, 2-N,N-diethylaminoethoxy, 2-N,N-diisopropylaminoethoxy, 2-(4 -Methylpiperazinyl)ethoxy, 2-(4-acetylpiperazinyl)ethoxy, 2-morpholinylethoxy, 2-thiophenarinylethoxy, 2-piperidinyl Ethoxy, 3-N,N-dimethylaminopropoxy, 3-N,N-diethylaminopropoxy, 3-N,N-diisopropylaminopropoxy, 3-( 4-Methylpiperazinyl)propoxy, 3-(4-Acetylpiperazinyl)propoxy, 3-morpholinopropoxy, 3-thiophenarinylpropoxy, 3-piperidine pyridin-2-ylmethoxy, pyridin-3-ylmethoxy, pyridin-4-ylmethoxy, phenylmethoxy, monohalogen substituted phenylmethoxy, geminal dihalogen Substituted phenylmethoxy, heterodihalogen substituted phenylmethoxy,

(7) Hydroxysulfonyl, aminosulfonyl, methylaminosulfonyl, ethylaminosulfonyl, propylaminosulfonyl, isopropylaminosulfonyl, cyclopropylaminosulfonyl, cyclobutylaminosulfonyl, cyclopentylamino Sulfonyl, piperidin-1-ylsulfonyl, 4-hydroxypiperidin-1-ylsulfonyl, 4-N,N-dimethylaminopiperidin-1-ylsulfonyl, 4-N,N-di Ethylaminopiperidin-1-ylsulfonyl, tetrahydropyrrolyl-1-sulfonyl, 3-N,N-dimethylaminotetrahydropyrrolyl-1-sulfonyl, 3-N,N-diethyl ylaminotetrahydropyrrolyl-1-sulfonyl, 4-methylpiperazin-1-ylsulfonyl, 4-ethylpiperazinyl-1-sulfonyl, 4-acetylpiperazinyl-1-sulfonyl , 4-tert-butoxycarbonylpiperazinyl-1-sulfonyl, 4-(2-hydroxyethyl)piperazinyl-1-sulfonyl, 4-(2-cyanoethyl)piperazinyl-1- Sulfonyl, 4-(2-N,N-dimethylaminoethyl)piperazinyl-1-sulfonyl, 4-(2-N,N-diethylethyl)piperazinyl-1-sulfonyl Acyl, 4-(3-hydroxypropyl)piperazinyl-1-sulfonyl, 4-(3-N,N-dimethylaminopropyl)piperazinyl-1-sulfonyl, 4-(3- N,N-Diethylaminopropyl)piperazinyl-1-sulfonyl, morpholinyl-1-sulfonyl, 3,5-dimethylmorpholinyl-1-sulfonyl, 4-(4- Methyl-piperazin-1-yl)piperidin-1-ylsulfonyl, 4-(4-ethyl-1-piperazinyl)piperidin-1-ylsulfonyl, 4-(4-acetyl- 1-Piperazinyl)piperidin-1-ylsulfonyl, 4-(N-methyl-4-piperidinyl)piperazinyl-1-sulfonyl,

(8) Hydroxycarbonyl, aminocarbonyl, methylaminocarbonyl, ethylaminocarbonyl, propylaminocarbonyl, isopropylaminocarbonyl, cyclopropylaminocarbonyl, cyclobutylaminocarbonyl, cyclopentylaminocarbonyl, piperidinyl-1- Carbonyl, 4-hydroxypiperidinyl-1-carbonyl, 4-N,N-dimethylaminopiperidinyl-1-carbonyl, 4-N,N-diethylaminopiperidinyl-1-carbonyl, tetra Hydropyrrolyl-1-carbonyl, 3-N,N-dimethylaminotetrahydropyrrolyl-1-carbonyl, 3-N,N-diethylaminotetrahydropyrrolyl-1-carbonyl, 4-methyl Piperazin-1-ylcarbonyl, 4-ethylpiperazinyl-1-carbonyl, 4-acetylpiperazinyl-1-carbonyl, 4-tert-butoxycarbonylpiperazinyl-1-carbonyl, 4-(2 -Hydroxyethyl)piperazinyl-1-carbonyl, 4-(2-cyanoethyl)piperazinyl-1-carbonyl, 4-(2-N,N-dimethylaminoethyl)piperazinyl -1-carbonyl, 4-(2-N,N-diethylaminoethyl)piperazinyl-1-carbonyl, 4-(3-hydroxypropyl)piperazinyl-1-carbonyl, 4-(3 -N,N-Dimethylaminopropyl)piperazinyl-1-carbonyl, 4-(3-N,N-diethylaminopropyl)piperazinyl-1-carbonyl, morpholinyl-1- Carbonyl, 3,5-dimethylmorpholinyl-1-carbonyl, 4-(4-methyl-piperazin-1-yl)piperidin-1-ylcarbonyl, 4-(4-ethyl-1- Piperazinyl)piperidinyl-1-carbonyl, 4-(4-acetyl-1-piperazinyl)piperidinyl-1-carbonyl, 4-(N-methyl-4-piperidinyl)piperazine yl-1-carbonyl, methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, tert-butoxycarbonyl,

(9) carbamoylamino, methylcarbamoylamino, ethylcarbamoylamino, propylcarbamoylamino, isopropylcarbamoylamino, cyclopropylcarbamoylamino, cyclobutylcarbamoylamino, cyclo Amylcarbamoylamino, piperidinyl-1-carboxamido, 4-hydroxypiperidinyl-1-carboxamido, 4-N,N-dimethylaminopiperidinyl-1-carboxamido, 4-N,N-Diethylaminopiperidinyl-1-carboxamido, tetrahydropyrrolyl-1-carboxamido, 3-N,N-dimethylaminotetrahydropyrrolyl-1-carboxyl Amino, 3-N,N-diethylaminotetrahydropyrrolyl-1-carboxamido, 4-methylpiperazinyl-1-carboxamido, 4-ethylpiperazinyl-1-carboxamido , 4-Acetyl piperazinyl-1-carboxamido, 4-tert-butoxycarbonyl piperazinyl-1-carboxamido, 4-(2-hydroxyethyl) piperazinyl-1-carboxamido, 4-(2-cyanoethyl)piperazinyl-1-carboxamido, 4-(2-N,N-dimethylaminoethyl)piperazinyl-1-carboxamido, 4-(2 -N,N-Diethylaminoethyl)piperazinyl-1-carboxamido, 4-(3-hydroxypropyl)piperazinyl-1-carboxamido, 4-(3-N,N- Dimethylaminopropyl)piperazinyl-1-carboxamido, 4-(3-N,N-diethylaminopropyl)piperazinyl-1-carboxamido, morpholino-1-methyl amido, 3,5-dimethylmorpholino-1-carboxamido, 4-(4-methyl-piperazin-1-yl)piperidinyl-1-carboxamido, 4-(4- Ethyl-1-piperazinyl)piperidinyl-1-carboxamido, 4-(4-acetyl-1-piperazinyl)piperidinyl-1-carboxamido, 4-(N-methyl -4-Piperidinyl)piperazinyl-1-carboxamido; or

(10) Z ₂ and Z ₃ or Z ₃ and Z ₄ form a nitrogen- or oxygen-containing substituted or unsubstituted five-membered ring or six-membered ring, and the substituents can be selected from the same substituents as Z ₁ ;

其中A₁，A₂，A₃，A₄，A₅各自独立地选自：R2 is selected from

wherein A ₁ , A ₂ , A ₃ , A ₄ , A ₅ are each independently selected from:

(1) hydrogen, fluorine, chlorine, bromine, iodine, cyano, trifluoromethyl, trifluoromethoxy, nitro,

(2) Methylthio, ethylthio, isopropylthio, methylsulfinyl, ethylsulfinyl, isopropylsulfinyl, methylsulfonyl, ethylsulfonyl, isopropylsulfonyl, tert-butanesulfonyl , dimethylaminosulfonyl, mesylamino, methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, n-butoxycarbonyl, isobutoxycarbonyl, tert-butoxycarbonyl , methylaminocarbonyl, ethylaminocarbonyl, propylaminocarbonyl, isopropylaminocarbonyl, dimethylaminocarbonyl, cyclopropylaminocarbonyl, cyclobutylaminocarbonyl, cyclopentylaminocarbonyl, dimethylphosphinoyl, diethyl phosphinoyl, diisopropylphosphinoyl.

其中Z₁，Z₂，Z₃，Z₄，Z₅各自独立地选自：In some embodiments, R1 is selected from:

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from:

(1) Hydrogen,

(2) C1-C6 alkoxy,

(3) piperidinyl, N-methyl-4-piperidinyl, 4-N,N-dimethylaminopiperidinyl, 4-N,N-diethylaminopiperidinyl, 4-N, N-diisopropylaminopiperidinyl, 4-hydroxypiperidinyl

(4) 4-(4-Methylpiperazinyl)piperidinyl, 4-(4-ethylpiperazinyl)piperidinyl, 4-(4-isopropylpiperazinyl)piperidinyl, 4 -(4-Acetylpiperazinyl)piperidinyl, 4-(4-tert-butoxycarbonylpiperazinyl)piperidinyl, 4-(4-methanesulfonylpiperazinyl)piperidinyl, 4-( 4-(2-Hydroxyethyl)piperazinyl)piperidinyl, 4-(4-(2-cyanoethyl)piperazinyl)piperidinyl, 4-(4-(3-hydroxypropyl) Piperazinyl) piperidinyl, 4-(4-(2-N,N-dimethylaminoethyl)piperazinyl)piperidinyl, 4-(4-(2-N,N-diethyl) Aminoethyl)piperazinyl)piperidinyl, 4-(4-(3-N,N-dimethylaminopropyl)piperazinyl)piperidinyl, 4-(4-(3-N,N -Diethylaminopropyl)piperazinyl)piperidinyl, 4-(tetrahydropyrrol-1-yl)piperidinyl, 4-(3-N,N-dimethylaminotetrahydropyrrolyl)piperidyl pyridyl,

(5) 4-methylpiperazinyl, 4-ethylpiperazinyl, 4-isopropylpiperazinyl, 4-acetylpiperazinyl, 4-tert-butoxycarbonylpiperazinyl, 4-methanesulfonic acid Acylpiperazinyl, 4-(2-hydroxyethyl)piperazinyl, 4-(2-cyanoethyl)piperazinyl, 4-(3-hydroxypropyl)piperazinyl, 4-(2- N,N-Dimethylaminoethyl)piperazinyl, 4-(2-N,N-diethylaminoethyl)piperazinyl, 4-(3-N,N-dimethylaminopropyl ) piperazinyl, 4-(3-N,N-diethylaminopropyl)piperazinyl, 4-(N-methyl-4-piperidinyl)piperazinyl, 4-(N-ethyl -4-Piperidinyl)piperazinyl, or

(6) Z ₂ and Z ₃ or Z ₃ and Z ₄ form a nitrogen- or oxygen-containing substituted or unsubstituted five-membered ring, and the substituents can be selected from the same substituents as those of Z ₁ .

In some embodiments, R1 is selected from:

其中Z₁，Z₂，Z₃，Z₄，Z₅各自独立地任选自：

Wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from:

(1) Hydrogen,

(2) C1-C6 alkoxy,

(3) 4-(4-methylpiperazinyl) piperidinyl, 4-methylpiperazinyl,

(4) Z ₂ and Z ₃ can form a nitrogen-containing substituted or unsubstituted five-membered ring

In some embodiments, R1 is selected from:

其中Z₁和Z₅二者之一为氢，另一为甲氧基；

Wherein one of Z ₁ and Z ₅ is hydrogen, and the other is methoxy;

Z ₃ is selected from: 4-methylpiperazinyl, 4-(4-methylpiperazinyl)piperidyl, or

Z ₂ and Z ₃ or Z ₃ and Z ₄ form

其中A₁，A₂，A₃，A₄，A₅各自独立地任选自：In some embodiments, R2 is selected from:

Wherein A ₁ , A ₂ , A ₃ , A ₄ , A ₅ are each independently selected from:

(1) Hydrogen

(2) Dimethylaminosulfonyl.

其中A₁和A₅二者之一为氢，另一为二甲氨基磺酰基；A₂，A₃，A₄都为氢。In some embodiments, R2 is selected from:

One of A ₁ and A ₅ is hydrogen, and the other is dimethylaminosulfonyl; A ₂ , A ₃ and A ₄ are all hydrogen.

Unless otherwise specified, the above-mentioned groups and substituents have their ordinary meanings in the field of medicinal chemistry.

It should be noted that the C1-C6 oxyalkyl group refers to the group formed by the substitution of the C1-C6 alkyl skeleton with one or more C1-C6 alkoxy groups, for example, methoxyethyl, methoxy ethoxymethyl, etc.

The term "C ₁ -C ₆ alkyl" refers to any straight or branched chain group containing 1 to 6 carbon atoms, such as methyl, ethyl, n-propyl, isopropyl, n-butyl, Isobutyl, tert-butyl, sec-butyl, n-pentyl, tert-amyl, n-hexyl, etc.

The term "C ₂ -C ₆ alkenyl" refers to any straight or branched chain radical group containing 2 to 6 carbon atoms and containing at least one alkenyl group, such as vinyl, allyl, 1-propene group, isopropenyl, 1-butenyl, 2-butenyl, 3-butenyl, 2-pentenyl, 1-hexenyl and the like.

The term "C ₂ -C ₆ alkynyl" refers to any straight or branched chain group containing 2 to 6 carbon atoms and containing at least one alkynyl group, such as ethynyl, 2-propynyl, 4-pentynyl Alkynyl etc.

According to the present invention and unless otherwise provided, any of the above groups may be optionally substituted at any of its free positions with one or more groups, such as 1-6 groups, independently selected from: Halogen atom, nitro group, oxo (=O), cyano group, C ₁ -C ₆ alkyl group, polyfluorinated alkyl group, polyfluorinated alkoxy group, alkenyl group, alkynyl group, hydroxyalkyl group, hydroxyalkyl group amino, hydroxyheterocyclyl, aryl, aryl-alkyl, heteroaryl, heteroaryl-alkyl, heterocyclyl, heterocyclyl-alkyl, C3 _{- C7cycloalkyl} , cycloalkyl -Alkyl, alkyl-aryl, alkyl-heteroaryl, alkyl-heterocyclyl, alkyl-cycloalkyl, alkyl-aryl-alkyl, alkyl-heteroaryl-alkyl, Alkyl-heterocyclyl-alkyl, alkyl-cycloalkyl-alkyl, alkyl-heterocyclyl-heterocyclyl, heterocyclyl-heterocyclyl, heterocyclyl-alkyl-heterocyclyl, Heterocyclyl-alkylamino, alkyl-heterocyclyl-alkyl-amino, hydroxy, alkoxy, aryloxy, heterocyclyloxy, alkyl-heterocyclyloxy, methylenedioxy , alkylcarbonyloxy, arylcarbonyloxy, cycloalkenyloxy, heterocyclylcarbonyloxy, alkyleneaminooxy, carboxyl, alkoxycarbonyl, aryloxycarbonyl, cycloalkyloxy carbonyl, heterocyclyloxycarbonyl, amino, ureido, alkylamino, amino-alkylamino, dialkylamino, dialkylamino-heterocyclyl, dialkylamino-alkylamino, arylamino , arylalkylamino, diarylamino, heterocyclylamino, alkyl-heterocyclylamino, alkyl-heterocyclylcarbonyl, carbonylamino, alkylcarbonylamino, arylcarbonylamino, heterocyclylcarbonyl Amino, alkyl-heterocyclylcarbonylamino, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, arylaminocarbonyl, heterocyclylaminocarbonyl, alkoxycarbonylamino, alkoxycarbonylamino-alkyl Amino, alkoxycarbonylheterocyclyl-alkylamino, alkoxy-aryl-alkyl, hydroxyamino-carbonyl, alkoxyimino, alkylsulfonylamino, arylsulfonylamino, heterocyclyl Sulfonylamino, formyl, alkylcarbonyl, arylcarbonyl, cycloalkylcarbonyl, heterocyclylcarbonyl, alkylsulfonyl, arylsulfonyl, aminosulfonyl, alkylaminosulfonyl, dialkylaminosulfonyl Acyl, arylaminosulfonyl, heterocyclylaminosulfonyl, arylthio, alkylthio, phosphonate and alkylphosphonate.

Furthermore, each of the aforementioned substituents may be further substituted with one or more of the aforementioned groups, if appropriate.

In this regard, the term "halogen atom" refers to a fluorine, chlorine, bromine or iodine atom.

The term "cyano" refers to a -CN residue.

The term "nitro" refers to the -NO ₂ group.

The terms "alkoxy", "cyclyloxy", "aryloxy", "heterocyclyloxy" and derivatives thereof refer to any of the aforementioned _{C1 - C6} alkyl, C3 _- C7 Cycloalkyl, aryl, or heterocyclyl, which is attached to the rest of the molecule through an oxygen atom (-O-).

The term "aryl" refers to a mono-, di- or poly-carbocyclic hydrocarbon having 1 to 2 ring systems optionally further fused or linked to each other by single bonds, wherein at least one of the carbocyclic rings is "Aromatic" wherein the term "aromatic" refers to a fully conjugated pi-electron bond system. The aryl ring can optionally be further fused or attached to aromatic and non-aromatic carbocyclic and heterocyclic rings. Non-limiting examples of such aryl groups are phenyl, alpha- or beta-naphthyl.

The term "heteroaryl" refers to an aromatic heterocycle, typically a 5- to 8-membered heterocycle having 1 to 3 heteroatoms selected from N, O or S; the heteroaryl ring may optionally Further fused or attached to aromatic and non-aromatic carbocyclic and heterocyclic rings. Non-limiting examples of such heteroaryl groups are eg pyridyl, pyrazinyl, pyrimidinyl, pyridazinyl, indolyl, imidazolyl, thiazolyl, isothiazolyl, thioxazolyl, pyrrolyl, benzene yl-pyrrolyl, furyl, phenyl-furyl, oxazolyl, isoxazolyl, pyrazolyl, thienyl, benzothienyl, isoindoline, benzimidazolyl, indazolyl , quinolinyl, isoquinolinyl, 1,2,3-triazolyl, 1-phenyl-1,2,3-triazolyl, 2,3-indoline, 2,3-diazolyl Hydrobenzofuranyl, 2,3-dihydrobenzothienyl, benzopyranyl, 2,3-dihydrobenzoxazinyl, 2,3-dihydroquinoxalinyl and the like.

The term "heterocyclyl" (also referred to as "heterocycloalkyl") refers to 3-, 4-, 5-, 6-, and 7-membered saturated or partially unsaturated carbocyclic rings in which one or more carbon atoms Replaced by heteroatoms such as nitrogen, oxygen and sulfur. Non-limiting examples of heterocyclyl groups are, for example, pyran, pyrrolidine, pyrroline, imidazoline, imidazolidine, pyrazolidine, pyrazoline, thiazoline, thiazolidine, dihydrofuran, tetrahydrofuran, 1,3- Dioxolane, piperidine, piperazine, morpholine, tetrahydropyrrolyl, thiomorpholinyl and the like.

The term "nitrogen- or oxygen-containing substituted or unsubstituted five- or six-membered ring" refers to a 5- or 6-membered saturated or partially unsaturated carbocyclic ring in which one or more carbon atoms are replaced by heteroatoms such as Nitrogen and oxygen replacement. A nitrogen- or oxygen-containing substituted or unsubstituted five- or six-membered ring is selected from pyrrolidine, pyrroline, pyrrole, imidazoline, imidazolidine, imidazole, pyrazolidine, pyrazoline, pyrazole, dihydrofuran , tetrahydrofuran, furan, 1,3-dioxolane, oxazole, dihydrooxazole; pyridine, pyrazine, pyrimidine, pyridazine, pyran, piperidine, piperazine, morpholine, etc.

From all of the above description, it will be apparent to those skilled in the art that any group whose name is a compound name, such as "arylamino", should refer to the moiety from which it is conventionally derived, such as from aryl substituted amino to construct, wherein aryl is as defined above.

Likewise, any term such as alkylthio, alkylamino, dialkylamino, alkoxycarbonyl, alkoxycarbonylamino, heterocyclylcarbonyl, heterocyclylcarbonylamino, cycloalkyloxycarbonyl, and the like includes groups , wherein the alkyl, alkoxy, aryl, C3 _{- C7cycloalkyl} and heterocyclyl moieties are as defined above.

As used herein, and unless otherwise specified, the term "prodrug" refers to a derivative that can be hydrolyzed, oxidized, or otherwise reacted under biological conditions (in vitro or in vivo) to provide a compound of the present invention. Prodrugs only undergo this reaction under biological conditions to become the active compound, or they are active in their unreacted form. Prodrugs can generally be prepared using well-known methods, such as those described in 1 Burger's Medicinal Chemistry and Drug Discovery (1995) 172-178, 949-982 (eds. Manfred E. Wolff, 5th ed.).

Pharmaceutically acceptable salts can be obtained using standard procedures well known in the art, eg, by reacting a sufficient amount of a basic compound with a suitable acid to provide a pharmaceutically acceptable anion.

The term "treating" as used herein generally refers to obtaining a desired pharmacological and/or physiological effect. The effect may be prophylactic in terms of complete or partial prevention of the disease or its symptoms; and/or therapeutic in terms of partial or complete stabilization or cure of the disease and/or side effects due to the disease. "Treatment" as used herein encompasses any treatment of a disease in a patient, including: (a) prevention of disease or symptoms in a patient susceptible to a disease or condition but not yet diagnosed; (b) suppression of symptoms of disease, That is, preventing its development; or (c) alleviating the symptoms of the disease, ie, causing the disease or symptoms to regress.

According to a specific technical solution of the present invention, the compound, its stereoisomer, its prodrug, or its pharmaceutically acceptable salt or pharmaceutically acceptable solvate, wherein the compound is the following example one of the compounds described in.

On the other hand, the present invention provides a pharmaceutical composition comprising the compound described in any of the above technical solutions, its stereoisomer, its prodrug, or its pharmaceutically acceptable salt or pharmaceutically acceptable Solvates, and pharmaceutically acceptable carriers, diluents or excipients.

Methods of preparing various pharmaceutical compositions containing amounts of active ingredients are known, or will be apparent to those skilled in the art in light of the present disclosure. Methods of preparing such pharmaceutical compositions include incorporating suitable pharmaceutical excipients, carriers, diluents, and the like, as described in Remington's Pharmaceutical Sciences, Martin, E.W., ed., Mack Publishing Company, 19th ed. (1995).

The pharmaceutical formulations of the present invention are manufactured by known methods, including conventional mixing, dissolving or lyophilization methods. The compounds of the present invention can be formulated into pharmaceutical compositions and administered to a patient by various routes suitable for the chosen mode of administration, eg, orally or parenterally (by intravenous, intramuscular, topical or subcutaneous routes).

Thus, the compounds of the present invention can be administered systemically, eg, orally, in combination with a pharmaceutically acceptable carrier such as an inert diluent or an assimilable edible carrier. They can be enclosed in hard or soft shell gelatin capsules and can be compressed into tablets. For oral therapeutic administration, the active compound may be incorporated with one or more excipients and presented in the form of swallowable tablets, buccal tablets, lozenges, capsules, elixirs, suspensions, syrups, wafers, and the like use. Such compositions and preparations should contain at least 0.1% active compound. The proportions of such compositions and formulations may, of course, vary and may range from about 1% to about 99% by weight of a given unit dosage form. In such therapeutically useful compositions, the active compound is in an amount such that an effective dosage level can be obtained.

Tablets, troches, pills, capsules, etc. may also contain: a binder, such as tragacanth, acacia, cornstarch, or gelatin; an excipient, such as dicalcium hydrogen phosphate; a disintegrant, such as cornstarch, Potato starch, alginic acid, etc.; lubricants, such as magnesium stearate; and sweeteners, such as sucrose, fructose, lactose, or aspartame; or flavoring agents, such as peppermint, oil of wintergreen, or cherry flavor. When the unit dosage form is a capsule, it can contain, in addition to materials of the above type, a liquid carrier such as a vegetable oil or polyethylene glycol. Various other materials may be present, as coatings, or otherwise alter the physical form of the solid unit dosage form. For example, tablets, pills or capsules may be coated with gelatin, wax, shellac or sugar and the like. A syrup or elixir may contain the active compound, sucrose or fructose as a sweetening agent, methyl or propyl paraben as a preservative, a dye and a flavoring (such as cherry flavor or orange flavor). Of course, any materials used in the preparation of any unit dosage form should be pharmaceutically acceptable and substantially non-toxic in the amounts to be used. In addition, the active compounds can be incorporated into sustained release formulations and sustained release devices.

The active compound may also be administered intravenously or intraperitoneally by infusion or injection. Aqueous solutions of the active compounds or salts thereof can be prepared, optionally mixed with nontoxic surfactants. Dispersions in glycerol, liquid polyethylene glycols, triacetin, and mixtures thereof and in oils can also be prepared. Under ordinary conditions of storage and use, these preparations contain a preservative to prevent the growth of microorganisms.

Pharmaceutical dosage forms suitable for injection or infusion can include sterile aqueous solutions or dispersions of the active ingredient (optionally encapsulated in liposomes) containing the active ingredient suitable for extemporaneous preparation in sterile injectable or infusible solutions or dispersions. or sterile powder. In all cases, the final dosage form must be sterile, liquid, and stable under the conditions of manufacture and storage. The liquid carrier can be a solvent or liquid dispersion medium containing, for example, water, ethanol, polyol (eg, glycerol, propylene glycol, liquid polyethylene glycol, and the like), vegetable oils, nontoxic glycerides, and suitable mixtures thereof. Proper fluidity can be maintained, for example, by the formation of liposomes, by the maintenance of the desired particle size in the case of dispersions, or by the use of surfactants. Prevention of microorganisms can be brought about by various antibacterial and antifungal agents such as parabens, chlorobutanol, phenol, sorbic acid, thimerosal, and the like. In many cases it is preferred to include isotonic agents such as sugars, buffers or sodium chloride. Prolonged absorption of the injectable compositions can be brought about by the use of agents which delay absorption, for example, aluminum monostearate and gelatin.

Sterile injectable solutions are prepared by incorporating the active compound in the required amount in an appropriate solvent with various of the other ingredients enumerated above as required, followed by filtered sterilization. In the case of sterile powders for the preparation of sterile injectable solutions, the preferred methods of preparation are vacuum drying and freeze-drying techniques, which yield a powder of the active ingredient plus any additional required ingredients previously present in sterile-filtered solutions .

Useful solid carriers include pulverized solids (eg, talc, clays, microcrystalline cellulose, silica, alumina, and the like). Useful liquid carriers include water, ethanol or ethylene glycol, or water-ethanol/ethylene glycol mixtures, in which the compounds of the present invention may be dissolved or dispersed at effective levels, optionally with the aid of non-toxic surfactants. Adjuvants (eg, fragrances) and additional antimicrobial agents can be added to optimize properties for a given use.

Thickeners such as synthetic polymers, fatty acids, fatty acid salts and esters, fatty alcohols, modified celluloses or modified inorganic materials can also be used with liquid carriers to form coatable pastes, gels, ointments , soap, etc., directly on the user's skin.

The therapeutically required amount of the compound or its active salt or derivative depends not only on the particular salt chosen, but also on the mode of administration, the nature of the disease to be treated and the age and status of the patient, and ultimately depends on the physician or clinician present decision.

The above formulations may be presented in unit dosage form, which are physically discrete units containing unitary dosages, suitable for administration to the human and other mammalian bodies. The unit dosage form can be a capsule or tablet, or a number of capsules or tablets. Depending on the particular treatment involved, the amount of active ingredient in a unit dose may vary or be adjusted from about 0.1 to about 1000 mg or more.

In addition, it also includes the application of various new pharmaceutical dosage forms such as milk liposomes, microspheres and nanospheres, such as the use of microparticle dispersion systems including polymeric micelles, nanoemulsion, submicroemuls Pharmaceutical preparations such as microcapsules, microspheres, liposomes and niosomes (also known as nonionic surfactant vesicles).

On the other hand, the present invention also provides a preparation method of the compound described in any of the above-mentioned technical solutions, comprising the following steps:

X=Cl or Br

Starting materials for this reaction are commercially available.

R'=H,Cl,Br

Reaction conditions: (a) substitution reaction under basic conditions (such as diisopropylethylamine, triethylamine, potassium carbonate, etc.) or acidic conditions (trifluoroacetic acid, hydrochloric acid, etc.); (b) acidic conditions (trifluoroacetic acid, etc.) acetic acid, hydrochloric acid, etc.) or palladium-catalyzed amination reaction.

On the other hand, the present invention also provides a compound described in any of the above technical solutions, its stereoisomer, its prodrug, or its pharmaceutically acceptable salt or pharmaceutically acceptable solvate in the preparation of prevention and use in the drug for the treatment of tumors. Preferably, wherein the tumor is graded large cell lymphoma, inflammatory myofibroblastic tumor, non-small cell lung cancer, neuroblastoma, small cell lung cancer, lung adenocarcinoma, pancreatic cancer, breast cancer, prostate cancer, Any one of liver cancer, skin cancer, epithelial cell carcinoma, gastrointestinal stromal tumor, leukemia, histiocytic lymphoma, and nasopharyngeal carcinoma; more preferably, wherein the tumor is graded large cell lymphoma, inflammatory Myofibroblastic tumor, non-small cell lung cancer, or neuroblastoma.

Detailed ways

Embodiments of the present invention will be described in detail below through specific examples, but they should not be construed as limiting the present invention in any way.

General Purification and Analysis Methods

和通过碘蒸气显影。当必要时，将化合物通过制备型HPLC制备经Waters Symmetry C18(19x50mm,5μm)柱或经Waters X Terra RP 18(30x 150mm,5μm)柱纯化，使用装配有996WatersPDA检测器的Waters制备型HPLC 600和Micromass mod.ZMD单四级质谱(电喷雾离子化，阳离子模式)。方法1：相A:0.1％TFA/MeOH 95/5；相B:MeOH/H₂O 95/5。梯度：10至90％B进行8min，保持90％B 2min；流速20mL/min。方法2：相A:0.05％NH₄OH/MeOH 95/5；相B:MeOH/H₂O95/5。梯度：10至100％B进行8min，保持100％B 2min。流速20mL/min。Thin-layer chromatography was performed on silica gel GF254 precoated plates (Qingdao Ocean Chemical Factory). Column chromatography was performed on silica gel (300-400 mesh, Yantai Zhihuangwu Silica Gel Development Reagent Factory) at medium pressure or by prepacked silica cartridges (ISCO or Welch) using an ISCO Combiflash Rf200 rapid purification system. ingredients pass UV light

and developed by iodine vapor. When necessary, compounds were purified by preparative HPLC on a Waters Symmetry C18 (19x50mm, 5μm) column or on a Waters X Terra RP 18 (30x 150mm, 5μm) column using a Waters Prep HPLC 600 equipped with a 996 WatersPDA detector and Micromass mod. ZMD single quaternary mass spectrometry (electrospray ionization, positive ion mode). Method 1: Phase A: 0.1% TFA/MeOH 95/5; Phase B: MeOH/ _H2O 95/5. Gradient: 10 to 90% B for 8 min, hold 90% B for 2 min; flow rate 20 mL/min. Method 2: Phase A: 0.05% _NH4OH /MeOH 95/5; Phase B: MeOH/ _H2O 95/5. Gradient: 10 to 100% B for 8 min, hold 100% B for 2 min. The flow rate was 20 mL/min.

化学位移

以百万分率(ppm)进行报道且偶合常数(J)以Hz计。以下缩写用于峰裂分:s＝单；br.s.＝宽信号；d＝双；t＝三；m＝多重；dd＝双双。 ¹ H-NMR spectra were recorded in DMSO-d ₆ or CDCl ₃ on a Bruker Avance 600 spectrometer (for ¹ H) operating at 600 MHz. Use residual solvent signal as reference

chemical shift

Reports are in parts per million (ppm) and coupling constants (J) are in Hz. The following abbreviations are used for peak splitting: s = single; br.s. = broad signal; d = double; t = triple; m = multiple; dd = double double.

Electrospray (ESI) mass spectra were acquired on a Finnigan LCQ ion trap.

All final compounds were homogeneous (no less than 95% pure) as determined by high performance liquid chromatography (HPLC) unless otherwise stated. HPLC-UV-MS analysis for evaluating compound purity was performed by combining ion trap MS equipment with HPLC system SSP4000 (Thermo Separation Products) equipped with autosampler LC Pal (CTC Analytics) and UV6000LP diode array Detector (UV detection 215-400 nm). Device control, data acquisition and processing were performed with Xcalibur 1.2 software (Finnigan). HPLC chromatography was performed at room temperature and a flow rate of 1 mL/min using a Waters X Terra RP 18 column (4.6 x 50 mm; 3.5 μm). Mobile phase A was ammonium acetate 5mM buffer (using acetic acid to give pH 5.5):acetonitrile 90:10, mobile phase B ammonium acetate 5mM buffer (using acetic acid to give pH 5.5):acetonitrile 10:90; gradient 0 to 100% B This was done for 7 minutes, then 100% B was held for 2 minutes before re-equilibration.

Reagent purification was carried out with reference to the book Purification of Laboratory Chemicals (Perrin, D.D., Armarego, W.L.F. and Perrins Eds, D.R.; Pergamon Press: Oxford, 1980). Petroleum ether is a 60-90°C fraction, and ethyl acetate, methanol, and dichloromethane are all analytically pure.

Compounds of the general formula above are divided into several classes of synthetic preparations.

General formula of compound I

Example 1

Synthetic formula of compound IA

Preparation of compound 3

Compound 2 (200 mg, 1.17 mmol) was dissolved in N,N-dimethylformamide (4 mL), sodium hydride (93.6 mg, 2.34 mmol) was added in an ice bath and stirred for 5-10 min, and then compound 1 ( 240.0 mg, 1.17 mmol), quenched after stirring at room temperature for 1.0 h (TLC tracking). Ice water was added to the system to quench sodium hydride, ethyl acetate was added and the solution was separated. The organic phase was washed twice with saturated sodium chloride solution, dried over anhydrous sodium sulfate, concentrated and subjected to silica gel column chromatography (petroleum ether/ethyl acetate). ester=5/1) to obtain compound 3 (solid, 270.0 mg, yield 79.5%), which was directly used in the next reaction.

MS(ESI) m/z: 340[M+H] ⁺ .

Preparation of Compound IA

Method A:

Compound 3 (30.0 mg, 0.09 mmol) and arylamine (0.072 mmol) were dissolved in 1 mL of tert-butanol, and 2-dicyclohexylphosphine-2,4,6-triisopropylbiphenyl was added to the solution. (7.7 mg, 0.016 mmol), tris(dibenzylideneacetone)dipalladium (9.9 mg, 0.011 mmol), potassium carbonate (37 mg, 0.27 mmol), under the protection of nitrogen, the resulting reaction solution was placed preheated to The reaction was stopped by heating and stirring in an oil bath at 110° C. until the reaction of the aromatic amine was complete (tracked by LC-MS and TLC). Methanol and dichloromethane were added to the reaction solution, the system was filtered, concentrated, and subjected to silica gel column chromatography (dichloromethane/methanol) to obtain compound IA.

Method B:

Compound 3 (30.0 mg, 0.09 mmol) and arylamine (0.072 mmol) were dissolved in 1 mL of tert-butanol, and 2-dicyclohexylphosphine-2,4,6-triisopropylbiphenyl was added to the solution. (7.7 mg, 0.016 mmol), tris(dibenzylideneacetone)dipalladium (9.9 mg, 0.011 mmol), potassium carbonate (37 mg, 0.27 mmol), under the protection of nitrogen, the resulting reaction solution was placed preheated to The reaction was stopped by heating and stirring in an oil bath at 110° C. until the reaction of the aromatic amine was complete (tracked by LC-MS and TLC). Methanol and dichloromethane were added to the reaction solution, and the system was filtered, concentrated and purified by reverse-phase preparative HPLC (using an aqueous solution containing 0.35% trifluoroacetic acid and methanol as mobile phases), and concentrated in vacuo to obtain compound IA.

Compounds IB and IC can be synthesized using similar methods.

The following table lists specific compounds and structural identification data.

Table 1. Structure and Characterization of Compounds IA-IC

Example 2

Synthetic formula of compound ID

Preparation of compound 5

Compound 1 (205 mg, 1.00 mmol) and compound 4 (151 mg, 1.00 mmol) were dissolved in 5 mL of tert-butanol, and 2-dicyclohexylphosphine-2,4,6-triisopropyl bicarbonate was added to the solution. Benzene (56 mg, 0.12 mmol), tris(dibenzylideneacetone)dipalladium (37 mg, 0.04 mmol), potassium carbonate (415 mg, 3.00 mmol), under the protection of nitrogen, the resulting reaction solution was preheated to 110 The mixture was heated and stirred in an oil bath at °C until the reaction of compound 1 was complete (tracked by LC-MS and TLC). Methanol and dichloromethane were added to the reaction solution, the system was filtered, the filtrate was concentrated and then diluted with dichloromethane, washed twice with saturated sodium chloride solution, dried over anhydrous sodium sulfate, concentrated and subjected to silica gel column chromatography (dichloromethane). Methane/ammonia methanol=10/1) to obtain compound 5 (white solid, 293.5 mg, yield 92.0%), which was directly used in the next reaction.

MS(ESI)m/z:320[M+H] ⁺

Preparation of Compound ID

Method A:

Compound 5 (31.8 mg, 0.10 mmol) and arylamine (0.09 mmol) were dissolved in 1 mL of tert-butanol, and 2-dicyclohexylphosphine-2,4,6-triisopropylbiphenyl was added to the solution. (0.018mmol), tris(dibenzylideneacetone)dipalladium (0.012mmol), potassium carbonate (0.30mmol), under the protection of nitrogen, the resulting reaction solution was placed in an oil bath preheated to 110°C with heating and stirring , the reaction was stopped when the reaction of compound 5 was completed (LC-MS and TLC tracking). Methanol and dichloromethane were added to the reaction solution, the system was filtered, concentrated, and subjected to silica gel column chromatography (dichloromethane/methanol) to obtain compound ID.

Method B:

Compound 5 (31.8 mg, 0.10 mmol) and arylamine (0.09 mmol) were dissolved in 1 mL of tert-butanol, and 2-dicyclohexylphosphine-2,4,6-triisopropylbiphenyl was added to the solution. (0.018mmol), tris(dibenzylideneacetone)dipalladium (0.012mmol), potassium carbonate (0.30mmol), under the protection of nitrogen, the resulting reaction solution was placed in an oil bath preheated to 110°C with heating and stirring , the reaction was stopped when the reaction of compound 5 was completed (LC-MS and TLC tracking). Methanol and dichloromethane were added to the reaction solution, and the system was filtered, concentrated and purified by reverse-phase preparative HPLC (using an aqueous solution containing 0.35% trifluoroacetic acid and methanol as mobile phases), and concentrated in vacuo to obtain compound ID.

Compounds IE, IF, IG, IH, II, IJ, IK can all be synthesized using similar methods.

The following table lists specific compounds and structural identification data.

Table 2. Compound ID—IK structure and characterization

Example 3

Synthetic formula of compound IL

Preparation of compound 7

Compound 6 (185.2 mg, 1.0 mmol) and triethylamine (0.418 mL, 3.0 mmol) were dissolved in N,N-dimethylformamide (1.5 mL), stirred at room temperature for 10 min, and added dropwise to compound 1 (205.0 mg, 1.0 mmol) in N,N-dimethylformamide (1.5 mL), stirred at room temperature overnight, (TLC tracking) to stop the reaction. Ethyl acetate was added to the system, water was extracted, the organic phase was washed with saturated sodium chloride solution, dried over anhydrous sodium sulfate, concentrated and subjected to silica gel column chromatography (petroleum ether/ethyl acetate=2/1) to obtain compound 7 (solid , 120.0 mg, 33.9% yield), which was directly used in the next reaction.

MS(ESI)m/z:354[M+H] ⁺

Preparation of compound IL

Method A:

Compound 7 (35.3 mg, 0.10 mmol) and arylamine (0.09 mmol) were dissolved in 1 mL of tert-butanol, and 2-dicyclohexylphosphine-2,4,6-triisopropylbiphenyl was added to the solution. (0.018mmol), tris(dibenzylideneacetone)dipalladium (0.012mmol), potassium carbonate (0.30mmol), under the protection of nitrogen, the resulting reaction solution was placed in an oil bath preheated to 110°C with heating and stirring , the reaction was stopped when the reaction of compound 7 was completed (LC-MS and TLC tracking). Methanol and dichloromethane were added to the reaction solution, the system was filtered, concentrated, and subjected to silica gel column chromatography (dichloromethane/methanol) to obtain compound IL.

Method B:

Compound 7 (35.3 mg, 0.10 mmol) and arylamine (0.09 mmol) were dissolved in 1 mL of tert-butanol, and 2-dicyclohexylphosphine-2,4,6-triisopropylbiphenyl was added to the solution. (0.018mmol), tris(dibenzylideneacetone)dipalladium (0.012mmol), potassium carbonate (0.30mmol), under the protection of nitrogen, the resulting reaction solution was placed in an oil bath preheated to 110°C with heating and stirring , the reaction was stopped when the reaction of compound 7 was completed (LC-MS and TLC tracking). Methanol and dichloromethane were added to the reaction solution, and the system was filtered, concentrated and purified by reverse-phase preparative HPLC (using an aqueous solution containing 0.35% trifluoroacetic acid and methanol as mobile phases), and concentrated in vacuo to obtain compound IL.

Compound IM can be synthesized using a similar method.

The following table lists specific compounds and structural identification data.

Table 3. Structure and characterization of compound IL-IM

Example 4

Synthetic formula of compound IN

Preparation of compound 9

Compound 1 (500 mg, 2.44 mmol) and compound 8 (0.09 mmol) were dissolved in 20 mL of tert-butanol, and 2-dicyclohexylphosphine-2,4,6-triisopropylbiphenyl ( 135mg, 0.17mmol), tris(dibenzylideneacetone)dipalladium (90mg, 0.06mmol), potassium carbonate (1.01g, 3.0mmol), under the protection of nitrogen, the resulting reaction solution was preheated to 45°C The reaction was stopped after heating and stirring in the oil bath of the compound 1 (LC-MS and TLC tracking) after the completion of the reaction of compound 1. The system was filtered and washed with methanol. The filtrate was concentrated and subjected to silica gel column chromatography (dichloromethane/amine methanol=5/1) to obtain compound 9 (yellow solid, 540 mg, yield 65.7%), which was directly used in the next reaction.

MS(ESI)m/z:337[M+H] ⁺

Preparation of compound IN

Compound 9 (50 mg, 0.15 mmol) and arylamine (0.13 mmol) were dissolved in 1 mL of tert-butanol, and to the solution was added trifluoroacetic acid (35 μL, 0.45 mmol). The resulting reaction solution was placed in an oil bath preheated to 110° C. with heating and stirring until the reaction of the aromatic amine was complete (tracked by LC-MS and TLC). The reaction was stopped, concentrated, purified by reverse-phase preparative HPLC (with 0.35% trifluoroacetic acid-containing aqueous solution and methanol as mobile phases), and concentrated in vacuo to obtain compound IN.

The following table lists specific compounds and structural identification data.

Table 4. Structure and Characterization of Compound IN

Example 5

Compound IO

Compound IO was synthesized using an analogous method for IA.

The following table lists specific compounds and structural identification data.

Table 5. Structure and Characterization of Compound IO

Example 6

Compound IP,IQ

Compounds IP, IQ were synthesized using a similar method for IA.

The following table lists specific compounds and structural identification data.

Table 6. Compound IP, IQ structure and characterization

Example 7

Compound IR, IS

Compounds IR and IS were synthesized using a similar method to IA.

The following table lists specific compounds and structural identification data.

Table 7. Compound IR, IS structure and characterization

Example 8

Compound IT

Compound IT was synthesized using a similar method to IA.

The following table lists specific compounds and structural identification data.

Table 8. Compound IT structure and characterization

Example 9

Compound IU

Compound IU was synthesized using an analogous method for IA.

The following table lists specific compounds and structural identification data.

Table 9. Compound IU structure and characterization

Test example

Biological activity test:

Growth Inhibitory Activity of Compounds on Kinase-Stable Cell Lines

The activity of compounds against the kinase ALK was evaluated by their inhibition of the growth of the kinase-stable cell lines EML4-ALK-BaF3, EML4-ALK(L1196M)-BaF3, NPM-ALK-BaF3, and wild-type BaF3 (Proc.Natl.Acad. Sci. U SA., 2006, 103, 3153-8.). The growth of the kinase-stable cell lines EML4-ALK-BaF3, EML4-ALK(L1196M)-BaF3 and NPM-ALK-BaF3 depends on their kinase activity. Compounds that inhibit the activity of the kinase ALK itself or the activity of the ALK signaling pathway can inhibit It stably transduced the growth of BaF3 cells. While the growth of wild-type BaF3 cells does not depend on the activity of ALK and ALK signaling pathways, measuring the effect of compounds on the growth of wild-type BaF3 cells can evaluate its broad-spectrum toxicity. Therefore, the greater the ratio of _IC50 between wild-type BaF3 and kinase-stabilized EML4-ALK-BaF3, EML4-ALK(L1196M)-BaF3, and NPM-ALK-BaF3 indicates better targeting.

The specific test methods are as follows:

1) Medium: DMEM (Dulbecco's modified eagle medium) or RPMI1640 (containing 10% fetal bovine serum, 100 μg/mL ampicillin, 100 μg/mL streptomycin).

2) Reagent: MTS reaction solution (containing 2 mg/mL of MTS[3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4- Sulfophenyl)-2H-tetrazolium,inner salt](3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium,inner salt ); 100 μg/mL of PES (phenazine methosulfate)).

3) Compound test: cells stably transduced with kinases (EML4-ALK-BaF3, or EML4-ALK(L1196M)-BaF3 or NPM-ALK-BaF3) (2×10 ⁴ cells/well) were placed in a 96-well culture plate , the volume of the cell fluid is 90 μL, and then 10 μL of each gradient concentration compound is added (the highest concentration is 10 μM, which is successively diluted by 1/3, a total of 8 concentration points are set, and the system contains 0.1% DMSO (dimethyl sulfoxide)) . The cell plate with the mixed compound was placed in a cell incubator (37°C; 5% CO ₂ ) for 48 hours, then 20 μL of MTS reaction solution was added, and the mixture was placed in a cell incubator (37° C; 5% CO ₂ ). Incubate for 1-4 hr; use a microplate reader (VARIOSKAN FLASH, Thermo) to measure the OD value at a wavelength of 490 nm. Three parallels were set for each group of experiments, with the final concentration of 0.1% DMSO as the negative control, and the medium without cells and compounds as the blank control. The cell growth inhibition rate was calculated by the following formula:

Cell inhibition rate%=1-(OD experimental group-OD blank group)/(OD negative group-OD blank group)*100%

4) IC ₅₀ value calculation: According to the measured cell growth inhibition rate, GradPad Prism 5 software was used to calculate the half-inhibitory concentration of the compound acting on cell growth.

Table 10. Growth inhibitory activity of compound I series on kinase stable cell lines

*Values represent the growth inhibition rate of cells at a compound concentration of 3.3 μM, Crizotinib was used as a positive control, ND means not determined.

Table 11. Growth inhibitory activity ( _IC50 /nM) of compound IB-1 on BaF3 cells stably transduced with other ALK point mutations

Growth Inhibitory Activity of Compounds on Tumor Cells

If the tumor cells to be tested are suspension cells, the measurement is carried out according to the method of (1) above.

If the tested tumor cells are adherent cells, add 1000-10000 cells/well to a 96-well culture plate, incubate until adherent, and then add compounds. Others are carried out with reference to the method of (1) above.

Compound IB-1 has good inhibitory activity on ALK-positive lung cancer cell line H3122 and graded large cell lymphoma Karpas-299. It can be seen from the above activity data that the compounds with better activity have better target selectivity.

Table 12. Growth inhibitory activity of compound IB-1 on tumor cells and BaF3 cells

*Crizotinib was used as a positive control, ND means not determined.

In vivo efficacy evaluation

1. Compound IB-1 significantly inhibited tumor growth in EML4-ALK(G1202R)-Ba/F3 nude mouse xenograft tumor model (Figure 1)

The experimental animals were BALB/c (nu/nu) nude mice, half male and half male, 4-6 weeks old, weighing about 18±2g, raised in an SPF environment, and strictly operated aseptically. The experimental animals were acclimated to the experimental environment one week in advance, had free access to food and water, and maintained a 12-h circadian rhythm.

The EML4-ALK(G1202R)-Ba/F3 cells used in the experiment were cultured with PRMI-1640 medium and 10% fetal bovine serum, and the cells were placed in a 37°C, 5% CO ₂ incubator environment.

The tumor nude mouse subcutaneous transplantation model was established by the cell inoculation method: the cells in the logarithmic growth phase were collected by filtration, washed with PBS after centrifugation, and resuspended in ^PRMI -1640 medium to form a single cell suspension. amount of cells. The cell suspension was subcutaneously injected near the right anterior axilla of nude mice with a 1 mL syringe (4.5 gauge needle). When the tumor of the tumor-bearing mice grew to a measurable size, the tumor volume was measured and calculated every day. When the tumor volume reached about 150 mm ³ , the mice were randomly divided into groups, with 8 mice in each group, for a total of three groups, and the administration began on the day of grouping. The administration components were IB-1 60 mg/kg (1 time/day), 40 mg/kg (2 times/day, bid), orally administered for 10 consecutive days, and the negative control group was given the same amount of solvent. During the experiment, the body weight and tumor size of the animals were measured every day, and the state of the mice was observed and recorded every day. The mice were anesthetized with 5% chloral hydrate 6 hours after the last administration, and the tumors were taken, weighed, and photographed for recording. The calculation formula of tumor volume (Tumor Volume, TV) is: TV=1/2×a×b ² , where a and b represent the long and short diameters of the tumor, respectively.

As shown in Figure 1, compound IB-1 significantly inhibited tumor growth in EML4-ALK(G1202R)-Ba/F3 nude mouse xenograft tumor model. A) Compound IB-1 was administered orally at 60 mg/kg (1 time/day) and 40 mg/kg (2 times/day, bid), respectively, for 10 consecutive days, the tumor growth was significantly inhibited; B) During the administration process, the body weight of the mice in the administration group did not change significantly, indicating that the mice had a good tolerance to the drug, and IB-1 had no obvious side effects.

2. Compound IB-1 significantly inhibited tumor growth in H3122 tumor cell nude mouse xenograft tumor model (Figure 2)

The experimental animals were BALB/c (nu/nu) nude mice, half male and half male, 4 to 6 weeks old, weighing about 18 ± 2 g, raised in an SPF environment, and subjected to strict aseptic operation. The experimental animals were acclimated to the experimental environment one week in advance, had free access to food and water, and maintained a 12-h circadian rhythm.

The NCI-H3122 cells used in the experiment were cultured with PRMI-1640 medium and 10% fetal bovine serum, and the cells were placed in a 37°C, 5% CO ₂ incubator environment.

The tumor nude mouse subcutaneous transplantation model was established by the cell inoculation method: the cells in the logarithmic growth phase were collected by filtration, washed with PBS after centrifugation, and resuspended in ^PRMI -1640 medium to form a single cell suspension. amount of cells. The cell suspension was subcutaneously injected near the right anterior axilla of nude mice with a 1 mL syringe (4.5 gauge needle). When the tumor of the tumor-bearing mice grew to a measurable size, the tumor volume was measured and calculated every day. When the tumor volume reached about 150 mm ³ , the mice were randomly divided into groups, with 5 mice in each group, with a total of four groups. The administration components were IB-1 30mg/kg (1 time/day), 50mg/kg (1 time/day), Crizotinib 50mg/kg (1 time/day) for the positive control group, and the same amount of solvent for the negative control group , for 18 consecutive days. During the test period, the body weight and tumor size of the animals were measured every day, and the state of the mice was observed and recorded every day. The mice were anesthetized with 5% chloral hydrate 6 hours after the last administration, and the tumors were taken out, weighed, and photographed for recording. The formula for calculating tumor volume (TV) is: TV=1/2×a×b ² , where a and b represent the long and short diameters of the tumor, respectively.

As shown in Figure 2, compound IB-1 significantly inhibited tumor growth in a nude mouse xenograft tumor model of non-small cell lung cancer H3122 cells. A) Compound IB-1 was administered orally at doses of 30 mg/kg (1 time/day) and 50 mg/kg (1 time/day), respectively, for 18 consecutive days, the tumor growth was significantly inhibited; B) After administration During the course of the drug, the body weight of the mice in the administration group did not change significantly, indicating that the mice had a good tolerance to the drug, and IB-1 had no obvious toxic and side effects.

The foregoing are merely some of the embodiments of the present invention. For those of ordinary skill in the art, without departing from the inventive concept of the present invention, several modifications and improvements can be made, which all belong to the protection scope of the present invention.

Claims (43)

1. Compounds of the following general formula I:

in, R' is hydrogen, chlorine or bromine; R1 is selected from _:

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from: (1) hydrogen, fluorine, chlorine, bromine, iodine, (2) C1-C6 alkyl, C1-C6 alkoxy, (3) 4-N,N-dimethylaminopiperidinyl, 4-N,N-diethylaminopiperidinyl, 4-N,N-diisopropylaminopiperidinyl, morpholinyl, 3,5-Dimethylmorpholinyl, 4-methylpiperazinyl, 4-ethylpiperazinyl, 4-isopropylpiperazinyl, (4) 4-(4-Methylpiperazinyl)piperidinyl, 4-(4-ethylpiperazinyl)piperidinyl, 4-(4-isopropylpiperazinyl)piperidinyl, 4 -(tetrahydropyrrolyl)piperidinyl, (5) carbamoylamino, methylcarbamoylamino, ethylcarbamoylamino, propylcarbamoylamino, isopropylcarbamoylamino; (6) Aminoacetamido, 2-dimethylaminoacetamido, N-tert-butoxycarbonylacetamido, N-acetylaminoacetamido, acrylamido, chloroacetamido; 2-methylaminoacetamido, 2- (1-methylethyl)aminoacetamido; (7) Z ₂ and Z ₃ or Z ₃ and Z ₄ form a nitrogen-containing substituted or unsubstituted five-membered ring; the substituents can be selected from the same as Z ₁ above-mentioned substituents, the nitrogen-containing substituted or unsubstituted The five-membered ring is selected from pyrroline; A is a direct bond or methylene; X is NH, S or O; R ₂ is selected from:

One of A ₁ and A ₅ is hydrogen, and the other is isopropylsulfonyl, tert-butanesulfonyl, dimethylaminosulfonyl, isopropylaminocarbonyl, dimethylaminocarbonyl, diethylphosphinoyl or Diisopropylphosphinoyl; A ₂ , A ₃ , A ₄ are all hydrogen; And does not include the following specific compounds:

or a pharmaceutically acceptable salt of the above compound, Wherein, the pharmaceutically acceptable salt is an inorganic acid salt or an organic acid salt, wherein the inorganic acid salt is hydrochloride, hydrobromide, hydroiodide, nitrate, bicarbonate and carbonic acid salt, sulfate or phosphate, the organic acid salt is formate, acetate, propionate, benzoate, maleate, fumarate, succinate, tartrate, citric acid salt, ascorbate, alpha-ketoglutarate, trifluoroacetate, alpha-glycerophosphate, alkylsulfonate or arylsulfonate. 2. A compound according to claim 1, wherein R' is hydrogen. 3. The compound according to claim 1, wherein R ₁ is selected from:

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from: (1) hydrogen, fluorine, chlorine, bromine, (2) C1-C6 alkyl, C1-C6 alkoxy, (3) 4-N,N-dimethylaminopiperidinyl, 4-N,N-diethylaminopiperidinyl, 4-N,N-diisopropylaminopiperidinyl, morpholinyl, 3,5-Dimethylmorpholinyl, 4-methylpiperazinyl, 4-ethylpiperazinyl, 4-isopropylpiperazinyl, (4) 4-(4-methylpiperazinyl)piperidinyl, 4-(4-ethylpiperazinyl)piperidinyl, 4-(4-isopropylpiperazinyl)piperidinyl, (5) carbamoylamino, methylcarbamoylamino, ethylcarbamoylamino, propylcarbamoylamino, isopropylcarbamoylamino; (6) aminoacetamido, N-tert-butoxycarbonylacetamido, N-acetylaminoacetamido, acrylamido, chloroacetamido; (7) Z ₂ and Z ₃ or Z ₃ and Z ₄ form a nitrogen-containing substituted or unsubstituted five-membered ring; the substituents can be selected from the same as Z ₁ above-mentioned substituents, the nitrogen-containing substituted or unsubstituted The five-membered ring is selected from pyrroline. 4. The compound according to claim 1, wherein A is a direct bond. 5. The compound according to claim 1, wherein A is methylene. 6. The compound according to claim 1, wherein the alkyl sulfonate is methyl sulfonate or ethyl sulfonate; and the aryl sulfonate is benzene sulfonate or p-toluene sulfonate. 7. The compound according to claim 1, which is of the following formula IB:

Wherein, R ₁ is selected from:

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from: (1) hydrogen, fluorine, chlorine, bromine, iodine, (2) C1-C6 alkyl, C1-C6 alkoxy, (3) 4-N,N-dimethylaminopiperidinyl, 4-N,N-diethylaminopiperidinyl, 4-N,N-diisopropylaminopiperidinyl, 4-(4 -Methylpiperazinyl)piperidinyl, 4-(4-ethylpiperazinyl)piperidinyl, 4-(4-isopropylpiperazinyl)piperidinyl, 4-(tetrahydropyrrolyl) piperidinyl, (4) 4-methylpiperazinyl, 4-ethylpiperazinyl, 4-isopropylpiperazinyl, (5) morpholinyl, 3,5-dimethylmorpholinyl, (6) 2-dimethylaminoacetamido,

(7) Z ₂ and Z ₃ or Z ₃ and Z ₄ form a nitrogen-containing substituted or unsubstituted five-membered ring, and the substituent can be selected from the same as Z _1. The above-mentioned substituents, the nitrogen-containing substituted or unsubstituted The five-membered ring is selected from pyrroline; R ₂ is selected from:

One of A ₁ and A ₅ is hydrogen, and the other is isopropylsulfonyl; A ₂ , A ₃ and A ₄ are all hydrogen; And does not include the following specific compounds:

or a pharmaceutically acceptable salt of the above compound. 8. The compound according to claim 7, wherein R ₁ is selected from:

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from: (1) Hydrogen, (2) C1-C6 alkyl, (3) C1-C6 alkoxy, (4) 4-(4-Methylpiperazinyl)piperidinyl, 4-(tetrahydropyrrolyl)piperidinyl, 4-N,N-dimethylaminopiperidinyl, 4-N,N- Diethylaminopiperidinyl, 4-N,N-diisopropylaminopiperidinyl, (5) 4-methylpiperazinyl, 4-ethylpiperazinyl, 4-isopropylpiperazinyl, (6) morpholinyl, 3,5-dimethylmorpholinyl, (7) Z ₂ and Z ₃ or Z ₃ and Z ₄ form a nitrogen-containing substituted or unsubstituted five-membered ring, and the substituent can be selected from the same as Z _1. The above-mentioned substituents, the nitrogen-containing substituted or unsubstituted The five-membered ring is selected from pyrroline. 9. The compound according to claim 7, wherein R ₁ is selected from:

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from: (1) Hydrogen, (2) 4-N,N-dimethylaminopiperidinyl, (3) 2-dimethylaminoacetamido,

(4) F. 10. The compound according to claim 7, wherein R ₁ is selected from:

Wherein one of Z ₂ and Z ₄ is hydrogen, and the other is selected from: 2-dimethylaminoacetamido,

Z ₃ is selected from: 4-N,N-dimethylaminopiperidinyl, F. 11. The compound according to claim 1, which is of the following formula IO:

R1 is selected from _:

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from: (1) hydrogen, fluorine, chlorine, bromine, iodine, (2) C1-C6 alkyl, C1-C6 alkoxy, (3) 4-N,N-dimethylaminopiperidinyl, 4-N,N-diethylaminopiperidinyl, 4-N,N-diisopropylaminopiperidinyl, 4-(4 -Methylpiperazinyl)piperidinyl, 4-(4-ethylpiperazinyl)piperidinyl, 4-(4-isopropylpiperazinyl)piperidinyl, 4-(tetrahydropyrrolyl) piperidinyl, (4) 4-methylpiperazinyl, 4-ethylpiperazinyl, 4-isopropylpiperazinyl, (5) carbamoylamino, methylcarbamoylamino, ethylcarbamoylamino, propylcarbamoylamino, isopropylcarbamoylamino; or (6) Z ₂ and Z ₃ or Z ₃ and Z ₄ form a nitrogen-containing substituted or unsubstituted five-membered ring, and the substituents can be selected from the same substituents as Z _1. The nitrogen-containing substituted or unsubstituted The five-membered ring is selected from pyrroline; R ₂ is selected from:

One of A ₁ and A ₅ is hydrogen, and the other is tert-butanesulfonyl; A ₂ , A ₃ and A ₄ are all hydrogen; or a pharmaceutically acceptable salt of the above compound. 12. The compound according to claim 11, wherein R ₁ is selected from

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from: (1) Hydrogen, (2) C1-C6 alkoxy, (3) 4-N,N-dimethylaminopiperidinyl, 4-N,N-diethylaminopiperidinyl, 4-N,N-diisopropylaminopiperidinyl, 4-(4 -Methylpiperazinyl)piperidinyl, 4-(4-ethylpiperazinyl)piperidinyl, 4-(4-isopropylpiperazinyl)piperidinyl, 4-(tetrahydropyrrolyl) piperidinyl, (4) 4-methylpiperazinyl, 4-ethylpiperazinyl, 4-isopropylpiperazinyl, or (5) Z ₂ and Z ₃ or Z ₃ and Z ₄ form a nitrogen-containing substituted or unsubstituted five-membered ring, and the substituent can be selected from the same as Z _1. The aforementioned substituents, the nitrogen-containing substituted or unsubstituted The five-membered ring is selected from pyrroline. 13. The compound according to claim 11, wherein R ₁ is selected from:

Wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from: (1) Hydrogen, (2) C1-C6 alkoxy (3) 4-(4-methylpiperazinyl) piperidinyl, 4-methylpiperazinyl, 4-N,N-dimethylaminopiperidinyl, (4) Z ₂ and Z ₃ can form a nitrogen-containing substituted or unsubstituted five-membered ring

14. The compound according to claim 11, wherein R ₁ is selected from:

in, Z ₁ is methoxy, and Z ₃ is selected from: 4-N,N-dimethylaminopiperidinyl, 4-methylpiperazinyl, 4-(4-methylpiperazinyl)piperidinyl, The remainder is hydrogen; or Z ₃ is formed with Z ₄

And Z ₁ is methoxy, and the rest are hydrogen. 15. The compound according to claim 1, which is of the formula IPQ:

R1 is selected from _:

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from: (1) hydrogen, fluorine, chlorine, bromine, iodine, (2) C1-C6 alkyl, C1-C6 alkoxy, (3) 4-N,N-dimethylaminopiperidinyl, 4-N,N-diethylaminopiperidinyl, 4-N,N-diisopropylaminopiperidinyl, 4-(4 -Methylpiperazinyl)piperidinyl, 4-(4-ethylpiperazinyl)piperidinyl, 4-(4-isopropylpiperazinyl)piperidinyl, 4-(tetrahydropyrrolyl) piperidinyl, (4) 4-methylpiperazinyl, 4-ethylpiperazinyl, 4-isopropylpiperazinyl, (5) carbamoylamino, methylcarbamoylamino, ethylcarbamoylamino, propylcarbamoylamino, isopropylcarbamoylamino; or (6) Z ₂ and Z ₃ or Z ₃ and Z ₄ form a nitrogen-containing substituted or unsubstituted five-membered ring, and the substituents can be selected from the same substituents as Z _1. The nitrogen-containing substituted or unsubstituted The five-membered ring is selected from pyrroline; R ₂ is selected from:

One of A ₁ and A ₅ is hydrogen, and the other is isopropylaminocarbonyl or dimethylaminocarbonyl; A ₂ , A ₃ , and A ₄ are all hydrogen; or a pharmaceutically acceptable salt of the above compound. 16. The compound according to claim 15, wherein R ₁ is selected from

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from: (1) Hydrogen, (2) C1-C6 alkoxy, (3) 4-N,N-dimethylaminopiperidinyl, 4-N,N-diethylaminopiperidinyl, 4-N,N-diisopropylaminopiperidinyl, 4-(4 -Methylpiperazinyl)piperidinyl, 4-(4-ethylpiperazinyl)piperidinyl, 4-(4-isopropylpiperazinyl)piperidinyl, 4-(tetrahydropyrrolyl) piperidinyl, (4) 4-methylpiperazinyl, 4-ethylpiperazinyl, 4-isopropylpiperazinyl, or (5) Z ₂ and Z ₃ or Z ₃ and Z ₄ form a nitrogen-containing substituted or unsubstituted five-membered ring, and the substituent can be selected from the same as Z _1. The aforementioned substituents, the nitrogen-containing substituted or unsubstituted The five-membered ring is selected from pyrroline. 17. The compound according to claim 15, wherein R ₁ is selected from:

Wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from: (1) Hydrogen, (2) C1-C6 alkoxy, (3) 4-(4-methylpiperazinyl)piperidinyl, 4-methylpiperazinyl, 4-N,N-dimethylaminopiperidinyl. 18. The compound according to claim 15, wherein R ₁ is selected from:

in Z ₁ is methoxy, and Z ₃ is selected from: 4-N,N-dimethylaminopiperidinyl, 4-methylpiperazinyl, 4-(4-methylpiperazinyl)piperidinyl, The remainder is hydrogen; or Z ₃ is formed with Z ₄

And Z ₁ is methoxy, and the rest are hydrogen. 19. The compound according to claim 1, which is of the formula IRS: Wherein, R ₁ is selected from:

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from: (1) hydrogen, fluorine, chlorine, bromine, iodine, (2) C1-C6 alkyl, C1-C6 alkoxy, (3) 4-N,N-dimethylaminopiperidinyl, 4-N,N-diethylaminopiperidinyl, 4-N,N-diisopropylaminopiperidinyl, 4-(4 -Methylpiperazinyl)piperidinyl, 4-(4-ethylpiperazinyl)piperidinyl, 4-(4-isopropylpiperazinyl)piperidinyl, 4-(tetrahydropyrrolyl) piperidinyl, (4) 4-methylpiperazinyl, 4-ethylpiperazinyl, 4-isopropylpiperazinyl, (5) carbamoylamino, methylcarbamoylamino, ethylcarbamoylamino, propylcarbamoylamino, isopropylcarbamoylamino; or (6) Z ₂ and Z ₃ or Z ₃ and Z ₄ form a nitrogen-containing substituted or unsubstituted five-membered ring, and the substituents can be selected from the same substituents as Z _1. The nitrogen-containing substituted or unsubstituted The five-membered ring is selected from pyrroline; R ₂ is selected from:

One of A ₁ and A ₅ is hydrogen, and the other is diisopropylphosphinoyl or diethylphosphinoyl; A ₂ , A ₃ , and A ₄ are all hydrogen; or a pharmaceutically acceptable salt of the above compound. 20. The compound according to claim 19, wherein R ₁ is selected from

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from: (1) Hydrogen, (2) C1-C6 alkoxy, (3) 4-N,N-dimethylaminopiperidinyl, 4-N,N-diethylaminopiperidinyl, 4-N,N-diisopropylaminopiperidinyl, 4-(4 -Methylpiperazinyl)piperidinyl, 4-(4-ethylpiperazinyl)piperidinyl, 4-(4-isopropylpiperazinyl)piperidinyl, 4-(tetrahydropyrrolyl) piperidinyl; (4) 4-methylpiperazinyl, 4-ethylpiperazinyl, 4-isopropylpiperazinyl, or (5) Z ₂ and Z ₃ or Z ₃ and Z ₄ form a nitrogen-containing substituted or unsubstituted five-membered ring, and the substituent can be selected from the same as Z _1. The aforementioned substituents, the nitrogen-containing substituted or unsubstituted The five-membered ring is selected from pyrroline. 21. The compound according to claim 19, wherein R ₁ is selected from

Wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from: (1) Hydrogen, (2) C1-C6 alkoxy, (3) 4-(Tetrahydropyrrolyl)piperidinyl, 4-methylpiperazinyl, 4-(4-methylpiperazinyl)piperidinyl, 4-N,N-dimethylaminopiperidine base; (4) Z ₂ and Z ₃ can form a nitrogen-containing substituted or unsubstituted five-membered ring

22. The compound according to claim 19, wherein R ₁ is selected from:

in One of Z ₁ and Z ₅ is hydrogen, and the other is methoxy; Z ₃ is selected from: 4-N,N-dimethylaminopiperidinyl, 4-methylpiperazinyl, 4-(4-methylpiperazinyl)piperidinyl, 4-(tetrahydropyrrolyl) piperidinyl, or Z ₂ and Z ₃ or Z ₃ and Z ₄ form

23. The compound according to claim 1, which is of formula IT:

Wherein, A is methylene; X is O; R1 is selected from _:

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from: (1) hydrogen, fluorine, chlorine, bromine, iodine, (2) C1-C6 alkyl, C1-C6 alkoxy, (3) 4-N,N-dimethylaminopiperidinyl, 4-N,N-diethylaminopiperidinyl, 4-N,N-diisopropylaminopiperidinyl, 4-(4 -Methylpiperazinyl)piperidinyl, 4-(4-ethylpiperazinyl)piperidinyl, 4-(4-isopropylpiperazinyl)piperidinyl, 4-(tetrahydropyrrolyl) piperidinyl, (4) 4-methylpiperazinyl, 4-ethylpiperazinyl, 4-isopropylpiperazinyl, (5) carbamoylamino, methylcarbamoylamino, ethylcarbamoylamino, propylcarbamoylamino, isopropylcarbamoylamino; (6) Morpholinyl; or (7) Z ₂ and Z ₃ or Z ₃ and Z ₄ form a nitrogen-containing substituted or unsubstituted five-membered ring, and the substituent can be selected from the same as Z _1. The above-mentioned substituents, the nitrogen-containing substituted or unsubstituted The five-membered ring is selected from pyrroline; R ₂ is selected from:

One of A ₁ and A ₅ is hydrogen, and the other is isopropylsulfonyl; A ₂ , A ₃ and A ₄ are all hydrogen; or a pharmaceutically acceptable salt of the above compound. 24. The compound according to claim 23, wherein R ₁ is selected from

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from: (1) Hydrogen, (2) C1-C6 alkoxy, (3) 4-N,N-dimethylaminopiperidinyl, 4-N,N-diethylaminopiperidinyl, 4-N,N-diisopropylaminopiperidinyl, 4-(4 -Methylpiperazinyl)piperidinyl, 4-(4-ethylpiperazinyl)piperidinyl, 4-(4-isopropylpiperazinyl)piperidinyl, 4-(tetrahydropyrrolyl) piperidinyl; (4) 4-methylpiperazinyl, 4-ethylpiperazinyl, 4-isopropylpiperazinyl, or (5) Z ₂ and Z ₃ or Z ₃ and Z ₄ form a nitrogen-containing substituted or unsubstituted five-membered ring, and the substituent can be selected from the same as Z _1. The aforementioned substituents, the nitrogen-containing substituted or unsubstituted The five-membered ring is selected from pyrroline. 25. The compound according to claim 23, wherein R ₁ is selected from:

Wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from: (1) Hydrogen, (2) C1-C6 alkoxy, (3) 4-methylpiperazinyl, 4-(4-methylpiperazinyl)piperidinyl, morpholinyl, 4-N,N-dimethylaminopiperidinyl. 26. The compound according to claim 23, wherein R ₁ is selected from:

in, One of Z ₁ and Z ₅ is hydrogen, and the other is methoxy; Z ₃ is selected from: 4-N,N-dimethylaminopiperidinyl, 4-methylpiperazinyl, 4-(4-methylpiperazinyl)piperidinyl, 4-methylpiperazinyl or Morpholine. 27. The compound according to claim 1, which is of the following formula IU:

Wherein, R ₁ is selected from:

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from: (1) hydrogen, fluorine, chlorine, bromine, iodine, (2) C1-C6 alkyl, C1-C6 alkoxy, (3) 4-N,N-dimethylaminopiperidinyl, 4-N,N-diethylaminopiperidinyl, 4-N,N-diisopropylaminopiperidinyl, 4-(4 -Methylpiperazinyl)piperidinyl, 4-(4-ethylpiperazinyl)piperidinyl, 4-(4-isopropylpiperazinyl)piperidinyl, 4-(tetrahydropyrrolyl) piperidinyl, (4) 4-methylpiperazinyl, 4-ethylpiperazinyl, 4-isopropylpiperazinyl, (5) carbamoylamino, methylcarbamoylamino, ethylcarbamoylamino, propylcarbamoylamino, isopropylcarbamoylamino; or (6) Z ₂ and Z ₃ or Z ₃ and Z ₄ form a nitrogen-containing substituted or unsubstituted five-membered ring, and the substituent can be selected from the same as Z _1. The above-mentioned substituents, the nitrogen-containing substituted or unsubstituted The five-membered ring is selected from pyrroline; R ₂ is selected from:

One of A ₁ and A ₅ is hydrogen, and the other is dimethylaminosulfonyl; A ₂ , A ₃ and A ₄ are all hydrogen; or a pharmaceutically acceptable salt of the above compound. 28. The compound according to claim 27, wherein R ₁ is selected from:

wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from: (1) Hydrogen, (2) C1-C6 alkoxy, (3) 4-N,N-dimethylaminopiperidinyl, 4-N,N-diethylaminopiperidinyl, 4-N,N-diisopropylaminopiperidinyl, (4) 4-(4-Methylpiperazinyl)piperidinyl, 4-(4-ethylpiperazinyl)piperidinyl, 4-(4-isopropylpiperazinyl)piperidinyl, 4 -(tetrahydropyrrolyl)piperidinyl, (5) 4-methylpiperazinyl, 4-ethylpiperazinyl, 4-isopropylpiperazinyl, or (6) Z ₂ and Z ₃ or Z ₃ and Z ₄ form a nitrogen-containing substituted or unsubstituted five-membered ring, and the substituent can be selected from the same as Z _1. The above-mentioned substituents, the nitrogen-containing substituted or unsubstituted The five-membered ring is selected from pyrroline. 29. The compound according to claim 27, wherein R ₁ is selected from:

Wherein Z ₁ , Z ₂ , Z ₃ , Z ₄ , Z ₅ are each independently selected from: (1) Hydrogen, (2) C1-C6 alkoxy, (3) 4-(4-methylpiperazinyl) piperidinyl, 4-methylpiperazinyl, (4) Z ₂ and Z ₃ can form a nitrogen-containing substituted or unsubstituted five-membered ring

30. The compound according to claim 27, wherein R ₁ is selected from:

Wherein one of Z ₁ and Z ₅ is hydrogen, and the other is methoxy; Z ₃ is selected from: 4-methylpiperazinyl, 4-(4-methylpiperazinyl)piperidyl, or Z ₂ and Z ₃ or Z ₃ and Z ₄ form

31. The compound according to any one of claims 7-30, wherein the pharmaceutically acceptable salt is an inorganic acid salt or an organic acid salt, wherein the inorganic acid salt is a hydrochloride salt, a hydrobromide salt , hydriodate, nitrate, bicarbonate and carbonate, sulfate or phosphate, the organic acid salts are formate, acetate, propionate, benzoate, maleate , fumarate, succinate, tartrate, citrate, ascorbate, alpha-ketoglutarate, trifluoroacetate, alpha-glycerophosphate, alkylsulfonate or arylsulfonate Salt. 32. The compound according to claim 31, wherein the alkyl sulfonate is methane sulfonate or ethyl sulfonate; and the aryl sulfonate is benzene sulfonate or p-toluene sulfonate. 33. A compound selected from the group consisting of:

or a pharmaceutically acceptable salt of the above compound. 34. A method of preparing the compound of any one of claims 1-33, comprising the steps of: 1)

The starting materials of this reaction are commercially available; 2)

Reaction conditions: (a) substitution reaction under basic conditions or acidic conditions; (b) amination reaction under acidic conditions or palladium catalyzed. 35. The method according to claim 34, wherein the basic condition is diisopropylethylamine, triethylamine or potassium carbonate. 36. The method according to claim 34, wherein the acidic condition is trifluoroacetic acid or hydrochloric acid. 37. A pharmaceutical composition comprising a compound of any one of claims 1-33, or a pharmaceutically acceptable salt thereof. 38. The pharmaceutical composition according to claim 37, further comprising a pharmaceutically acceptable excipient. 39. Use of a compound of any one of claims 1-33 or a pharmaceutically acceptable salt thereof or a pharmaceutical composition of any one of claims 37-38 in the manufacture of a medicament for prophylaxis or treatment Diseases associated with abnormal cell proliferation, morphological changes, and hyperkinesia associated with progressive lymphoma enzymes in vivo, and prevention or treatment of diseases related to angiogenesis or cancer metastasis. 40. Use of a compound of any one of claims 1-33, or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition of any one of claims 37-38, in the manufacture of a medicament for prophylaxis Or to treat tumor growth and metastasis. 41. The use according to claim 40, wherein the tumor is graded large cell lymphoma, inflammatory myofibroblastic tumor, non-small cell lung cancer, neuroblastoma, small cell lung cancer, pancreatic cancer, breast cancer, Any of prostate cancer, liver cancer, skin cancer, epithelial cell carcinoma, gastrointestinal stromal tumor, leukemia, histiocytic lymphoma, and nasopharyngeal carcinoma. 42. The use according to claim 41, wherein the non-small cell lung cancer is lung adenocarcinoma. 43. The use according to claim 40, wherein the tumor is a graded large cell lymphoma, inflammatory myofibroblastic tumor, non-small cell lung cancer or neuroblastoma.

Images