CN109528566B

CN109528566B - A kind of traditional Chinese medicine antibacterial hand sanitizer and preparation method thereof

Info

Publication number: CN109528566B
Application number: CN201910058669.9A
Authority: CN
Inventors: 周婕; 姜银杰; 周清萍
Original assignee: Yichun University
Current assignee: Yichun University
Priority date: 2019-01-22
Filing date: 2019-01-22
Publication date: 2021-01-05
Anticipated expiration: 2039-01-22
Also published as: CN109528566A

Abstract

The invention aims to provide a traditional Chinese medicine bacteriostatic hand sanitizer with a good bacteriostatic effect, which is characterized by comprising the following components in percentage by mass: 0.4 to 1.0 percent of phellodendron ketone, 1.2 to 1.8 percent of forsythia essential oil, 1.5 to 2.3 percent of atractylodes essential oil, 0.1 to 0.4 percent of preservative, 0.3 to 0.8 percent of solubilizer, 1.2 to 3 percent of humectant, 0.1 to 0.5 percent of flavoring agent, 4 to 8 percent of foaming agent, 4 to 10 percent of foaming agent, 0.05 to 0.4 percent of metal ion chelating agent and the balance of deionized water. The traditional Chinese medicine bacteriostatic hand sanitizer has a better bacteriostatic effect than a conventional bacteriostatic hand sanitizer containing traditional Chinese medicine essential oil, and also has the advantages of low irritation and high cleaning capability, so that the traditional Chinese medicine bacteriostatic hand sanitizer is suitable for popularization and use and has a good application value.

Description

Traditional Chinese medicine bacteriostatic hand sanitizer and preparation method thereof

Technical Field

The invention belongs to the field of daily necessities, relates to a hand sanitizer and a preparation method thereof, and particularly relates to a traditional Chinese medicine antibacterial hand sanitizer and a preparation method thereof.

Background

The hand sanitizer is a common daily product and is used for cleaning hands.

In order to achieve a better cleaning effect, especially a bacteria removing and inhibiting effect, some bacteria inhibiting type hand sanitizer in the prior art is provided, wherein a certain amount of bacteriostatic agent is added, so that a user can better remove bacteria while washing hands.

At present, the common bacteriostatic agents in daily necessities mainly comprise phenols, boric acids and the like, and in addition, common preservatives such as parabens and traditional bactericides such as sulfur and the like also serve as bacteriostatic agents and are widely applied to the field of daily necessities. However, these ingredients are mostly chemically synthesized ingredients or natural ingredients having strong irritation, and general users are reluctant to use daily necessities having too many synthesized ingredients or having irritation.

Therefore, in recent years, researchers in the field of daily necessities have paid more attention to the development of natural bacteriostatic components, such as essential oil bacteriostatic components extracted from various traditional Chinese medicines. However, the extracted essential oils generally have low bacteriostatic activity, and it is difficult to achieve the desired bacteriostatic effect.

Disclosure of Invention

The inventor of the invention researches different types of traditional Chinese medicine essential oil, combination and effects of the traditional Chinese medicine essential oil, finds that when phellodendron ketone, forsythia essential oil and atractylodes essential oil are used together, the bacteriostatic effect of the two essential oils is promoted, so that the three components can generate better bacteriostatic effect after being mixed.

Based on the above findings, the inventors propose a bacteriostatic hand sanitizer containing obacunone, forsythia essential oil and atractylodes essential oil. Specifically, the invention provides a traditional Chinese medicine antibacterial hand sanitizer which is characterized by comprising the following components in percentage by mass: 0.4 to 1.0 percent of phellodendron ketone, 1.2 to 1.8 percent of forsythia essential oil, 1.5 to 2.3 percent of atractylodes essential oil, 0.1 to 0.4 percent of preservative, 0.3 to 0.8 percent of solubilizer, 1.2 to 3 percent of humectant, 0.1 to 0.5 percent of flavoring agent, 8 to 18 percent of foaming agent, 0.05 to 0.4 percent of metal ion chelating agent and the balance of deionized water.

The traditional Chinese medicine antibacterial hand sanitizer provided by the invention can also have the technical characteristics that the preservative is sorbic acid, the solubilizer is polysorbate 80, the humectant is glycerin, the flavoring agent is essence, the foaming agent comprises dodecyl betaine and cocamidopropyl betaine, and the metal ion chelating agent is EDTA-4 Na.

The traditional Chinese medicine antibacterial hand sanitizer provided by the invention also has the technical characteristics that the mass percent of the dodecyl betaine is 4-8%, and the mass percent of the cocamidopropyl betaine is 4-10%.

The traditional Chinese medicine antibacterial hand sanitizer provided by the invention also has the technical characteristics that the mass percent of phellodendron ketone is 0.8%, the mass percent of fructus forsythiae essential oil is 1.6%, and the mass percent of rhizoma atractylodis macrocephalae essential oil is 2.1%.

The invention also provides a preparation method of the traditional Chinese medicine antibacterial hand sanitizer, which is characterized by comprising the following steps: step S1, putting deionized water into a clean container, adding the preservative, the solubilizer, the humectant, the flavoring agent, the foaming agent and the metal ion chelating agent while stirring at room temperature until the materials are completely dissolved and uniformly dispersed to prepare phase A; and step S2, adding the phellodendron ketone, the forsythia essential oil and the bighead atractylodes rhizome essential oil into the phase A, and uniformly stirring at room temperature until a stable clear solution system is formed. And step S3, standing at room temperature for a preset time, and filtering to obtain the traditional Chinese medicine bacteriostatic hand sanitizer.

The preparation method of the traditional Chinese medicine bacteriostatic hand sanitizer provided by the invention can also have the technical characteristics that the stirring rotation speeds in the steps S1 and S2 are 200 revolutions per minute.

The preparation method of the traditional Chinese medicine antibacterial hand sanitizer provided by the invention can also have the technical characteristics that the preparation process of the forsythia essential oil is as follows: weighing fructus forsythiae powder, placing in a dry container, and mixing according to the weight ratio of 12: adding distilled water with the liquid-solid ratio of 1, sealing, soaking for 17-19 h, and heating in an oil bath at 120 ℃ for 6h to obtain distilled volatile oil; extracting volatile oil with anhydrous ether, adding small amount of anhydrous sodium sulfate, drying, sealing, placing in refrigerator at 4 deg.C overnight, filtering, and evaporating ether with rotary evaporator to obtain fructus forsythiae essential oil.

The preparation method of the traditional Chinese medicine bacteriostatic hand sanitizer provided by the invention can also have the technical characteristics that the preparation process of the bighead atractylodes rhizome essential oil is as follows: weighing Atractylodis rhizoma powder, placing in a drying container, adding ethyl acetate at a liquid-solid ratio of 6:1, shaking, sealing, placing in the shade, soaking at 22-24 deg.C for 3 times with 12h ultrasound for 20min each time to obtain leachate; filtering the leaching solution, recovering ethyl acetate by adopting a rotary film decompression method, adding a small amount of anhydrous sodium sulfate into the residual liquid to remove water and dry, and filtering to obtain the white atractylodes rhizome essential oil.

Action and Effect of the invention

According to the traditional Chinese medicine bacteriostatic hand sanitizer provided by the invention, the traditional Chinese medicine bacteriostatic hand sanitizer contains 0.4-1.0% of phellodendron ketone, 1.2-1.8% of fructus forsythiae essential oil and 1.5-2.3% of bighead atractylodes rhizome essential oil in percentage by mass, wherein the phellodendron ketone can promote the bacteriostatic action of the fructus forsythiae essential oil and the bighead atractylodes rhizome essential oil, so that the bacteriostatic effect is improved when the phellodendron ketone, the fructus forsythiae essential oil and the bighead atractylodes rhizome essential oil are used together, and therefore, the traditional Chinese medicine bacteriostatic hand sanitizer has a better bacteriostatic effect than that of a conventional bacteriostatic hand sanitizer containing the traditional Chinese. In addition, the traditional Chinese medicine bacteriostatic hand sanitizer also has the advantages of low irritation and high cleaning capability, so that the traditional Chinese medicine bacteriostatic hand sanitizer is suitable for popularization and use and has good application value.

Detailed Description

The following examples are given to illustrate specific embodiments of the present invention.

In each of the following examples, the hand sanitizer was prepared by the following steps:

step S1, putting deionized water into a clean container, stirring at room temperature (200 revolutions per minute) while adding sorbic acid (as a preservative), polysorbate 80 (as a solubilizer for increasing dissolution of essential oil, hereinafter abbreviated as polysorbate), glycerin (as a humectant), essence (as a flavoring agent), dodecyl betaine (as a foaming agent), cocamidopropyl betaine (also as a foaming agent) and EDTA-4Na (as a metal ion chelating agent) until complete dissolution and uniform dispersion are achieved to obtain phase A;

and step S2, adding the phellodendron ketone, the forsythia essential oil and the bighead atractylodes rhizome essential oil into the phase A, and uniformly stirring at room temperature (a magnetic stirrer rotates at 200 revolutions per minute) until a stable clear solution system is formed.

And step S3, standing at room temperature for 24h, and filtering to obtain the hand sanitizer.

The fructus forsythiae essential oil and the bighead atractylodes rhizome essential oil used in the process are both prepared by the inventor in a laboratory, and the obacunone and other reagents are purchased by common commercial ways.

The preparation process of the forsythia essential oil comprises the following steps: weighing 20g of fructus forsythiae powder with a 30-mesh sieve, placing the fructus forsythiae powder in a dry 1-L round-bottom flask, adding 240mL of distilled water according to the liquid-solid ratio of 12:1, sealing, soaking for 18h, connecting a volatile oil extractor and a condenser tube, placing the instrument on a temperature-controllable magnetic stirrer, and heating and extracting for 6h in a 120 ℃ oil bath. Extracting the distilled volatile oil with anhydrous ether, adding small amount of anhydrous sodium sulfate, drying, sealing, placing in refrigerator at 4 deg.C overnight, filtering, and evaporating ether with rotary evaporator to obtain bright yellow oily liquid, i.e. fructus forsythiae essential oil.

Through a process parameter comparison experiment, the inventor of the invention determines that the optimal process conditions of the forsythia essential oil are as follows: the soaking time is 18h, the liquid-solid ratio is 12:1, the extraction time is 6h, and the yield of the forsythia essential oil is the highest and is 1.67 percent under the condition.

The preparation process of the white atractylodes rhizome essential oil is as follows: weighing 30g of 20-mesh bighead atractylodes rhizome powder, placing the powder into a dry 500mL conical flask, adding 180mL of ethyl acetate according to the liquid-solid ratio of 6:1, shaking up, sealing, placing the flask in the shade at the ambient temperature of 22-24 ℃, soaking for 12h every time, and carrying out ultrasonic treatment for 20min for 3 times to obtain a leaching solution. Filtering the leaching solution, recovering ethyl acetate by adopting a rotary film decompression method, adding a small amount of anhydrous sodium sulfate into the residual liquid to remove water and dry, and filtering to obtain golden yellow oily liquid, namely the white atractylodes rhizome essential oil.

Through a process parameter comparison experiment, the inventor of the invention determines that the optimal process conditions of the white atractylodes rhizome essential oil are as follows: the organic solvent of the leaching method is ethyl acetate, the liquid-solid ratio is 6:1, the environmental temperature is 24 ℃, the soaking time is 12h, the ultrasonic treatment is carried out for 20min for 3 times, and the yield of the white atractylodes rhizome essential oil is the highest and is 2.83 percent under the condition.

In addition, the processes are mainly physical mixing processes, so the content ratio of each component in the finally obtained hand sanitizer is equal to the addition amount of the components. In the following description, the contents of the respective components are the amounts added, and the percentages thereof are the mass percentages. Obviously, the content also corresponds to the mass percentage content of each component in the finished hand sanitizer.

< example 1>

Example 1 is a preparation experiment of the traditional Chinese medicine bacteriostatic hand sanitizer.

In example 1, the contents of the components are: 0.8% of phellodendron ketone, 1.6% of fructus forsythiae essential oil, 2.1% of bighead atractylodes rhizome essential oil, 0.3% of sorbic acid, 0.4% of polysorbate, 2% of glycerin, 0.2% of essence, 4.6% of dodecyl betaine, 5.8% of cocamidopropyl betaine, 0.12% of EDTA-4Na and the balance of deionized water.

< example 2>

Example 2 is a preparation experiment of the traditional Chinese medicine bacteriostatic hand sanitizer.

In example 2, the contents of the components are: 0.8% of phellodendron ketone, 1.6% of fructus forsythiae essential oil, 2.1% of bighead atractylodes rhizome essential oil, 0.3% of sorbic acid, 0.4% of polysorbate, 2% of glycerin, 0.2% of essence, 4.6% of dodecyl betaine, 5.8% of cocamidopropyl betaine, 0.12% of EDTA-4Na and the balance of deionized water.

< example 3>

Example 3 is a preparation experiment of the traditional Chinese medicine bacteriostatic hand sanitizer.

In example 3, the contents of the components were: 0.6% of phellodendron ketone, 1.7% of fructus forsythiae essential oil, 1.8% of bighead atractylodes rhizome essential oil, 0.2% of sorbic acid, 0.3% of polysorbate, 1.8% of glycerol, 0.3% of essence, 6.3% of dodecyl betaine, 6.3% of cocamidopropyl betaine, 0.18% of EDTA-4Na and the balance of deionized water.

The following comparative examples are comparative experiments with hand sanitizer. In the following comparative examples, the preparation process of the hand sanitizer is the same as that of the above examples, namely, the components except the bacteriostatic component (essential oil) are mixed to prepare the phase A, then the bacteriostatic component is added into the phase A, and the hand sanitizer is prepared by stirring and filtering.

< comparative example 1>

The hand sanitizer of comparative example 1 of the present invention contains the following components in mass percent: 1.6% of fructus forsythiae essential oil, 2.1% of bighead atractylodes rhizome essential oil, 0.3% of sorbic acid, 0.4% of polysorbate, 2% of glycerin, 0.2% of essence, 4.6% of dodecyl betaine, 5.8% of cocamidopropyl betaine, 0.12% of EDTA-4Na and the balance of deionized water.

< comparative example 2>

The hand sanitizer of comparative example 2 of the present invention contains the following components in mass percent: 0.8% of phellodendron ketone, 2.1% of bighead atractylodes rhizome essential oil, 0.3% of sorbic acid, 0.4% of polysorbate, 2% of glycerin, 0.2% of essence, 4.6% of dodecyl betaine, 5.8% of cocamidopropyl betaine, 0.12% of EDTA-4Na and the balance of deionized water.

< comparative example 3>

The hand sanitizer of comparative example 3 of the present invention contains the following components in mass percent: 0.8% of phellodendron ketone, 1.6% of fructus forsythiae essential oil, 0.3% of sorbic acid, 0.4% of polysorbate, 2% of glycerin, 0.2% of essence, 4.6% of dodecyl betaine, 5.8% of cocamidopropyl betaine, 0.12% of EDTA-4Na and the balance of deionized water.

< comparative example 4>

The hand sanitizer of comparative example 4 of the present invention contains the following components in mass percent: 0.8% of phellodendron ketone, 0.3% of sorbic acid, 0.4% of polysorbate, 2% of glycerol, 0.2% of essence, 4.6% of dodecyl betaine, 5.8% of cocamidopropyl betaine, 0.12% of EDTA-4Na and the balance of deionized water.

< comparative example 5>

The hand sanitizer of comparative example 5 of the present invention contains the following components in mass percent: 0.3% of phenol, 0.3% of sorbic acid, 0.4% of polysorbate, 2% of glycerol, 0.2% of essence, 4.6% of dodecyl betaine, 5.8% of cocamidopropyl betaine, 0.12% of EDTA-4Na and the balance of deionized water.

< comparative example 6>

The hand sanitizer of comparative example 6 of the present invention contains the following components in mass percent: 0.3% of phenol, 0.8% of phellodendron ketone, 0.3% of sorbic acid, 0.4% of polysorbate, 2% of glycerol, 0.2% of essence, 4.6% of dodecyl betaine, 5.8% of cocamidopropyl betaine, 0.12% of EDTA-4Na and the balance of deionized water.

< comparative example 7>

The hand sanitizer of comparative example 7 of the present invention contains the following components in mass percent: 0.3% of phenol, 1.6% of fructus forsythiae essential oil, 2.1% of bighead atractylodes rhizome essential oil, 0.3% of sorbic acid, 0.4% of polysorbate, 2% of glycerin, 0.2% of essence, 4.6% of dodecyl betaine, 5.8% of cocamidopropyl betaine, 0.12% of EDTA-4Na and the balance of deionized water.

Effects and effects of the embodiments

The function and effect of the bacteriostatic hand sanitizer prepared by the embodiment of the invention are described in the following by combining the performance test results of the above embodiments and comparative examples.

1. Experiment for inhibiting bacteria

According to appendix C4 of GB15797-2002 hygienic Standard for Disposable sanitary articles, the antibacterial performance test method of the dissolution antibacterial product is adopted to detect the antibacterial level of the hand sanitizer of each example and each comparative example by a suspension quantitative method.

Wherein, the strains to be detected are three types of bacteria of staphylococcus aureus (ATCC 6538), escherichia coli (ATCC 25922) and candida albicans (ATCC 10231), the detection concentration is 1:100, the action time is 20min, and the results are shown in the following table 1.

Table 1 results of tests on bacteriostatic properties of hand sanitizers of examples and comparative examples

Group of	Staphylococcus aureus inhibition (%)	Escherichia coli inhibition (%)	Candida albicans inhibition (%)
				Example 1	98.73	99.24	99.02
Example 2	97.85	98.19	99.27
				Example 3	98.23	99.08	98.15
Comparative example 1	52.36	55.47	54.29
				Comparative example 2	91.08	88.49	86.21
Comparative example 3	92.41	90.32	89.77
				Comparative example 4	84.51	80.27	81.38
Comparative example 5	85.48	78.26	78.55
				Comparative example 6	88.92	86.37	83.04
Comparative example 7	86.03	79.95	80.06

As can be seen directly from table 1, the hand sanitizer of examples 1 to 3 has good bacteriostatic effect, and the inhibitory rate of the hand sanitizer on three common bacteria, namely staphylococcus aureus, escherichia coli and candida albicans, reaches more than 97%.

When example 1 is compared with comparative example 1, it can be seen that when phellodendron ketone is not used, forsythia essential oil and atractylodis macrocephalae essential oil are inferior in bacteriostatic effect even when they are used in combination.

Comparing example 1 with comparative example 1, comparative example 2 and comparative example 3 respectively, it can be seen that when fructus forsythiae essential oil and obacunone are mixed or rhizoma atractylodis macrocephalae essential oil and obacunone are mixed, the inhibition rate of the three bacteria can reach about 90%, and the inhibition effect of the obacunone on the two essential oils is promoted.

Comparing comparative example 4 and comparative example 5, it can be seen that 0.8% of obacunone and 0.3% of phenol have almost the same bacteriostatic effect; further, comparing example 1 with comparative example 7, it can be seen that the bacteriostatic rate of 0.8% of obacunone mixed with forsythia suspensa essential oil and atractylodes macrocephala essential oil is significantly higher than that of phenol mixed with two essential oils, which means that the promoting effect of obacunone on the bacteriostatic effect of forsythia suspensa essential oil and atractylodes macrocephala essential oil is not due to the superposition of the bacteriostatic effect of obacunone itself and the bacteriostatic effect of essential oil. In addition, comparing comparative example 4, comparative example 5 and comparative example 6, it can be seen that the bacteriostasis rate is slightly improved after the phellodendron ketone and the phenol are mixed, which indicates that the bacteriostasis effects are superposed after the two bacteriostatics are mixed, but the improvement of the bacteriostasis effects is different from the promotion effects of the phellodendron ketone on the forsythia essential oil and the atractylodes essential oil. The inventor speculates that the effect is probably related to pinene components contained in fructus forsythiae essential oil and lactone components contained in rhizoma atractylodis macrocephalae essential oil, phellodendron ketone not only has a certain antibacterial effect, but also can generate a synergistic effect with the active components, so that the antibacterial ability of the two essential oils is greatly improved, and the common antibacterial agent phenol cannot play the role.

Combining the results of the above examples and comparative examples, the following conclusions can be drawn: the phellodendron ketone has a promoting effect on the bacteriostatic effect of the forsythia suspense essential oil and the atractylodes macrocephala essential oil, and the promoting effect is not generated by simple superposition of the bacteriostatic effect. Therefore, the bacteriostatic effect of the hand sanitizer product can be greatly improved by mixing the phellodendron ketone, the forsythia essential oil and the atractylodes essential oil, so that the bacteriostatic standard of the bacteriostatic hand sanitizer is reached.

2. Skin irritation test

This experiment was a skin irritation experiment using the hand lotions of examples 1 to 3.

The specific process is as follows: 90 healthy adult college students are recruited and randomly divided into 3 groups, each group contains 30 students, 1mL of hand sanitizer is respectively smeared on the palm and the back of the hand of each student, the palm and the back of the hand are covered by medical gauze and fixed by non-irritant adhesive tapes. After being smeared for 3h, the skin is washed by water to remove residues, and then local skin reactions are observed at 30min,1h,2h,12h,24h and 48h after the removal.

The results show that no adverse reaction occurs on the skin in all the 3 groups of subjects, and no uncomfortable symptoms such as erythema, edema, pruritus and the like are found at the tested part. The hand washing solutions of examples 1 to 3 were mild, safe, and free from skin irritation, and were suitable for daily use.

3. Washing effect test

This experiment is a cleaning effect test using the hand washing solutions of examples 1 to 3 and a general commercial hand washing solution.

The specific process is as follows: 120 healthy adult college students were recruited and randomly divided into 4 groups of 30 persons each, and the cleaning ability evaluation and the sensory evaluation were performed on the liquid soap.

The tests all adopt self-control, 2cm by 5cm test areas are drawn on the palm and the back side of the hand of a volunteer respectively, lipstick with the area of 1cm by 4cm is uniformly smeared in the test areas, the liquid soap to be tested is used for washing the lipstick in a circling mode for half a minute in the cleaning process, and then the lipstick is washed by running water. After washing, the washing effect and the condition of the remaining lipstick were observed and recorded, and the significant removal of lipstick was recorded as "significant effect", the removal of lipstick by more than half was recorded as "significant effect", and the removal of lipstick by more than half was recorded as "insignificant change", and the removal of lipstick by almost no significant change was recorded as "ineffective".

The results of the above washing effect test are shown in table 2 below.

TABLE 2 washing effectiveness test results of hand sanitizer

Group of	Show effect	Is effective	Invalidation	Significant efficiency (%)	Effective rate (%)
						Example 1	30	0	0	100％	100％
Example 2	29	1	0	96.7％	100％
						Example 3	28	2	0	93.3％	100％
Commercially available product	26	4	0	86.7％	100％

In addition, through feedback of a test subject, compared with a product sold in the market, the hand sanitizer in the embodiments 1 to 3 can generate creamy, rich and fine foam better in use, has good hand feeling during washing, strong detergency, low irritation, more convenient washing, good hand moisturizing effect after washing hands, and has a moisturizing effect on skin.

From the results of the performance tests, it can be known that the bacteriostatic traditional Chinese medicine hand sanitizer in the embodiment contains 0.4-1.0% of obacunone, 1.2-1.8% of fructus forsythiae essential oil and 1.5-2.3% of rhizoma atractylodis macrocephalae essential oil in percentage by mass, wherein the obacunone can promote the bacteriostatic action of the fructus forsythiae essential oil and the rhizoma atractylodis macrocephalae essential oil, so that the bacteriostatic effect is improved when the obacunone, the fructus forsythiae essential oil and the rhizoma atractylodis macrocephalae essential oil are used together, and therefore, the bacteriostatic traditional Chinese medicine hand sanitizer in the embodiment has a better bacteriostatic effect than that of a conventional bacteriostatic hand sanitizer containing traditional Chinese medicine essential. In addition, the traditional Chinese medicine bacteriostatic hand sanitizer also has the advantages of low irritation and high cleaning capability, so that the traditional Chinese medicine bacteriostatic hand sanitizer is suitable for popularization and use and has a good application value.

Claims

1. a traditional Chinese medicine antibacterial hand sanitizer, is characterized in that, in mass percent, is made up of following composition:

Phellodendri 0.4%-1.0%, Forsythia Essential Oil 1.2%-1.8%, Atractylodes Rhizoma Essential Oil 1.5%-2.3%, Preservative 0.1%-0.4%, Solubilizer 0.3%-0.8%, Moisturizer 1.2%-3%, Corrective Flavor agent 0.1%-0.5%, foaming agent 8%-18%, metal ion chelating agent 0.05%-0.4%, the balance is deionized water,

Wherein, the preservative is sorbic acid, the solubilizer is polysorbate 80, the moisturizing agent is glycerin, the flavoring agent is essence, and the foaming agent is lauryl betaine and coconut oil The composition of amidopropyl betaine, the metal ion chelating agent is EDTA-4Na,

The preparation process of described forsythia essential oil is as follows:

Weigh forsythia powder and place it in a dry container, add distilled water to seal at a liquid-solid ratio of 12:1, soak for 17h-19h, heat and extract in an oil bath at 120°C for 6h to obtain the distilled volatile oil;

The volatile oil was extracted with anhydrous ether, and a small amount of anhydrous sodium sulfate was added to absorb water and dry, sealed and placed in a refrigerator at 4° C. overnight, filtered and then evaporated using a rotary evaporator to obtain the forsythia essential oil;

The preparation process of described Atractylodes Rhizoma essential oil is as follows:

Weigh the Atractylodes Rhizoma powder and place it in a dry container, add ethyl acetate in a liquid-solid ratio of 6:1, shake well, seal it, and place it in a dark indoor place. Ultrasonic for 20min, a total of 3 times to obtain the leachate;

After the leachate is filtered, the ethyl acetate is recovered by a rotating film decompression method, and a small amount of anhydrous sodium sulfate is added to the remaining liquid to remove water and dry, and the essential oil of Atractylodes Atractylodes is obtained after filtration.

2. Chinese medicine antibacterial hand sanitizer according to claim 1, is characterized in that:

Wherein, the mass percentage of described dodecyl betaine is 4%-8%,

The mass percentage of the cocamidopropyl betaine is 4%-10%.

3. Chinese medicine antibacterial hand sanitizer according to claim 1, is characterized in that:

Wherein, the mass percentage of the yellow ketone is 0.8%,

The mass percentage of the forsythia essential oil is 1.6%,

The mass percentage of the essential oil of Atractylodes Rhizoma is 2.1%.

4. the preparation method of traditional Chinese medicine antibacterial hand sanitizer as claimed in claim 1, is characterized in that, comprises the steps:

Step S1, put deionized water into a clean container, add preservatives, solubilizers, moisturizing agents, flavoring agents, foaming agents and metal ion chelating agents while stirring at room temperature until it is completely dissolved and uniformly dispersed, and the system is prepared. get phase A;

Step S2, adding Phellodendron, Forsythia quintessence oil and Atractylodes Rhizoma quintessence oil to described A phase, stir at room temperature, until the stable clear solution system is formed;

In step S3, the traditional Chinese medicine antibacterial hand sanitizer is obtained after standing at room temperature for a predetermined time and then filtering.

5. the preparation method of traditional Chinese medicine antibacterial hand sanitizer according to claim 4, is characterized in that:

Wherein, the rotational speed of the stirring in step S1 and step S2 is both 200 revolutions per minute.