CN109520987B - ATP fluorescent detector - Google Patents
ATP fluorescent detector Download PDFInfo
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- CN109520987B CN109520987B CN201811555267.1A CN201811555267A CN109520987B CN 109520987 B CN109520987 B CN 109520987B CN 201811555267 A CN201811555267 A CN 201811555267A CN 109520987 B CN109520987 B CN 109520987B
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- 238000001514 detection method Methods 0.000 claims abstract description 73
- 239000011148 porous material Substances 0.000 claims abstract description 13
- 238000005119 centrifugation Methods 0.000 claims abstract description 3
- 239000000463 material Substances 0.000 claims description 6
- 238000012360 testing method Methods 0.000 claims description 6
- 238000001816 cooling Methods 0.000 claims description 5
- 229920000742 Cotton Polymers 0.000 claims description 3
- 230000003247 decreasing effect Effects 0.000 claims description 3
- 230000033228 biological regulation Effects 0.000 claims description 2
- 230000003287 optical effect Effects 0.000 claims 4
- ZKHQWZAMYRWXGA-KQYNXXCUSA-J ATP(4-) Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]1O ZKHQWZAMYRWXGA-KQYNXXCUSA-J 0.000 description 24
- ZKHQWZAMYRWXGA-UHFFFAOYSA-N Adenosine triphosphate Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C(O)C1O ZKHQWZAMYRWXGA-UHFFFAOYSA-N 0.000 description 24
- 238000000034 method Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 239000005089 Luciferase Substances 0.000 description 1
- TTWYZDPBDWHJOR-IDIVVRGQSA-L adenosine triphosphate disodium Chemical compound [Na+].[Na+].C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]1O TTWYZDPBDWHJOR-IDIVVRGQSA-L 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000005415 bioluminescence Methods 0.000 description 1
- 230000029918 bioluminescence Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000001917 fluorescence detection Methods 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 230000017525 heat dissipation Effects 0.000 description 1
- 238000004020 luminiscence type Methods 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 230000007269 microbial metabolism Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Optics & Photonics (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Abstract
The invention discloses an ATP fluorescence detector, which comprises a shell with an opening at the top, wherein a light-proof box body is fixedly arranged on a bottom plate of the shell and positioned below the opening, a detection position for placing a detection chip is arranged on the light-proof box body, and a detection hole is formed in the detection position; a centrifugal motor and a mounting plate are arranged in the light-shielding box body, and the centrifugal motor is used for driving the detection chip to carry out centrifugation; the mounting plate is provided with a light hole switching mechanism, the light hole switching mechanism comprises a switching motor and a detection element, the switching motor and the detection element are fixed on the mounting plate, and the detection element is provided with a lens; the detection element is provided with a switching pore plate, and a plurality of light holes with different sizes are sequentially arranged on the switching pore plate along the length direction; the switching motor is used for driving the switching pore plate to move along the length direction, and the light quantity of the lens is adjusted by switching different light holes. The ATP fluorescence detector can adjust the fluorescence quantity entering the detector according to the occurrence quantity of fluorescence, and can adapt to different detection requirements.
Description
Technical Field
The invention relates to the technical field of fluorescence detection equipment, in particular to an ATP fluorescence detector.
Background
ATP (Adenosine Triphosphate) Chinese is called adenosine triphosphate, also called adenosine triphosphate. It is commonly found in microbial cells such as bacteria, and ATP is the energy substance of microbial metabolism. The ATP bioluminescence method is to utilize several components in ATP reagent, such as luciferin-luciferase, to react with the sample to be tested to generate photons, and then to utilize specially developed equipment to capture and detect luminescence values. The ATP fluorescence detector is a device for rapidly detecting ATP based on the above principle.
Currently, there are two types of ATP fluorescence detectors commonly used in the market, a handheld ATP fluorescence detector and a desk-top ATP fluorescence detector. The handheld ATP fluorescence detector has small volume, meets the requirement of on-site rapid detection, and is widely applied to on-site detection in mobile places such as catering service, medical sensing control and the like; the desk-top ATP fluorescence detector is bulky, and sensitivity is high. However, the existing desk-top ATP fluorescence detector cannot adjust the amount of fluorescence entering the detector according to the amount of fluorescence generated, and therefore cannot adapt to different detection requirements.
Disclosure of Invention
The invention aims to solve the technical problem of providing an ATP fluorescence detector which can adjust the amount of fluorescence entering the detector according to the occurrence amount of fluorescence and can adapt to different detection requirements.
In order to solve the technical problems, the invention provides an ATP fluorescence detector, which comprises a shell, wherein the top of the shell is provided with an opening, a light-shielding box body is fixedly arranged below the opening on a bottom plate of the shell, a detection position for placing a detection chip is arranged on the light-shielding box body, and a detection hole allowing fluorescence emitted by a sample in the detection chip to penetrate is formed in the detection position;
A centrifugal motor and a mounting plate are arranged in the light-shading box body, and the centrifugal motor is used for driving a detection chip on a detection position to carry out centrifugation; the mounting plate is provided with a light hole switching mechanism, the light hole switching mechanism comprises a switching motor and a detection element, the switching motor and the detection element are fixed on the mounting plate, the detection element is used for detecting the fluorescence intensity transmitted through the detection hole, and a lens is arranged on the detection element; the detection element is provided with a switching pore plate, a plurality of light holes with different sizes are sequentially formed in the switching pore plate along the length direction, and the light holes are used for conducting the light path of the lens;
the switching motor is used for driving the switching pore plate to move along the length direction, and the light quantity of the lens is adjusted by switching different light holes.
In a preferred embodiment of the invention, a gear is fixed on a main shaft of the switching motor, a rack meshed with the gear is arranged on one side of the switching pore plate, and the switching motor drives the switching pore plate to move along the length direction through the gear and the rack.
In a preferred embodiment of the present invention, the detecting element is fixedly provided with a limiting support, the limiting support is provided with a chute matched with the switching orifice plate, and the switching orifice plate is slidably connected in the chute.
In a preferred embodiment of the invention, the detection element is further provided with a position sensor for detecting the limit position of the movement of the switching orifice plate.
In a preferred embodiment of the present invention, the light transmitting hole is a circular hole with a gradually increasing/decreasing caliber along the length direction of the switching hole plate.
In a preferred embodiment of the invention, the fixing part of the light-shielding box body and the bottom plate of the shell is filled with light-shielding materials.
In a preferred embodiment of the present invention, the light-shielding material is light-shielding cotton.
In a preferred embodiment of the invention, a display screen is arranged on the shell, and a cover plate is hinged on the shell corresponding to the opening.
In a preferred embodiment of the invention, the shell is provided with a power interface, and the bottom plate of the shell is provided with an MCU, a photon counter, a first switching power supply for MCU power supply, a second switching power supply for photon counter power supply and a third switching power supply for centrifugal motor power supply and speed regulation.
In a preferred embodiment of the invention, a radiator for cooling the MCU is arranged on the bottom plate of the housing, and at least one cooling fan is arranged on the housing.
In a preferred embodiment of the present invention, the housing is further provided with a printing module, so that the detection result can be printed in real time.
In a preferred embodiment of the present invention, a serial interface is further provided on the housing, through which the uploading of the detection result can be achieved.
The invention has the beneficial effects that:
According to the ATP fluorescence detector, the fluorescence quantity of the lens in the detection element can be adjusted according to the fluorescence generation quantity of the sample in the detection chip, so that different detection requirements are met, and the ATP fluorescence detector is wide in applicability; secondly, the detection of multiple samples at one time can be realized by matching with the corresponding micro-fluidic chip, and the detection efficiency is high.
Drawings
FIG. 1 is a schematic diagram showing the external structure of an ATP fluorescence detector according to an embodiment of the present invention;
FIG. 2 is a schematic diagram showing the internal structure of the ATP fluorescence detector in FIG. 1;
FIG. 3 is a schematic view of the internal structure of the light-shielding case;
Fig. 4 is a schematic structural view of a light hole switching mechanism;
the reference numerals in the figures illustrate:
100. A housing; 110. a cover plate; 120. an inclined plane; 130. a display screen; 140. a printing module; 150. a work indicator light; 160. a heat radiation fan; 170. a power interface; 180. a serial interface; 190. supporting feet;
200. a light-shielding box body; 201. detecting a position; 202. a detection hole; 203. a light-shielding filling layer; 210. a centrifugal motor; 211. a motor bracket; 212. a mounting plate; 213. an optocoupler sensor; 214. testing the grating; 215. a reflective optocoupler; 220. a light hole switching mechanism; 221. switching the motor; 222. a gear; 223. a detection element; 224. a position sensor; 225. a limit bracket; 226. switching the pore plate; 227. a rack; 228. a light hole;
300. A first switching power supply; 400. a fixed bracket; 410. an MCU; 420. a photon counter; 500. a second switching power supply; 600. a third switching power supply; 700. a heat sink.
Detailed Description
The present invention will be further described with reference to the accompanying drawings and specific examples, which are not intended to be limiting, so that those skilled in the art will better understand the invention and practice it.
Referring to fig. 1, an embodiment of the ATP fluorescence detector of the present invention includes a casing 100 having a box shape, a plurality of supporting legs 190 are provided at the bottom of the casing 100, a left half of the top is opened, a cover plate 110 is hinged at the opening, and a fastening structure is provided between the cover plate 110 and the casing 100, so as to be fastened on the casing 100 conveniently. The right half part of the top of the shell 100 forms an inclined plane 120, and a display screen 130 is arranged on the inclined plane 120 and can display information such as detection data, motor rotation speed and the like; it is preferably a touch screen through which the operating parameters of the fluorescence detector can be set. In addition, a printing module 140 is further arranged on the top of the shell 100, and is used for printing the detection result in real time; the casing 100 is further provided with a work indicator lamp 150 for displaying the work state.
Referring to fig. 2, a light-shielding box 200 is fixedly arranged below the opening on the bottom plate of the housing 100, a detection position 201 for placing a detection chip is arranged on the light-shielding box 200, and a detection hole 202 allowing fluorescence emitted by a sample in the detection chip to pass through is arranged on the detection position 201. In this embodiment, the detection position 201 is an annular area surrounded by a shroud. In order to achieve strict light shielding, a light shielding filling layer 203 is formed at a fixing position of the light shielding case 200 and the bottom plate of the case 100. Preferably, the material of the light-shielding filling layer 203 is light-shielding cotton, and in other embodiments, other light-shielding materials may be used.
A motor bracket 211 is fixed on a bottom plate in the light-shielding box body 200, a vertical centrifugal motor 210 is fixed on the motor bracket 211, and a main shaft of the centrifugal motor 210 penetrates through a top plate of the light-shielding box body 200 and is used for driving a detection chip on the detection position 201 to be centrifuged.
Still be equipped with horizontal mounting panel 212 in the light-proof box 200, be provided with opto-coupler sensor 213 and reflection opto-coupler 214 on this mounting panel 212, be equipped with test grating 215 on the main shaft of centrifugal motor, wherein, reflection opto-coupler 214 cooperation test grating 215 is used for measuring centrifugal motor 210's rotational speed, and centrifugal motor 210 cooperation opto-coupler sensor 213 has still played the effect of location chip detection hole.
The mounting plate 212 is further provided with a light hole switching mechanism 220, specifically, referring to fig. 4, the light hole 228 switching mechanism 400 includes a switching motor 221 and a detecting element 223 fixed on the mounting plate 212, and the detecting element 223 is used for detecting the fluorescence intensity transmitted through the detecting hole 202, and has a lens (not shown) thereon, and preferably, the position of the lens is located directly below the detecting hole 202. The detecting element 223 is fixedly provided with a limiting support 225, the limiting support 225 is provided with a chute, and a switching pore plate 226 is connected in the chute in a sliding way. The switching orifice plate 226 is an elongated plate, one long side of which is partially provided with a rack 227, and a gear 222 engaged with the rack 227 is mounted on the main shaft of the switching motor 221. The switching orifice plate 226 is driven to reciprocate in the length direction by the rotation of the switching motor 221. Those skilled in the art will appreciate that in alternative embodiments, the manner in which the switching orifice plate 226 is driven to move includes, but is not limited to, that shown in FIG. 4, other manners in which the switching orifice plate 226 may be driven to move, such as a lead screw slider mechanism, for example.
The switching hole plate 226 is sequentially provided with a plurality of light holes 228 with different sizes along the length direction, and in the moving process of the switching hole plate 226, the plurality of light holes 228 respectively pass through the lens, so that the light path is conducted, and fluorescence emitted by a sample in the detection chip can enter the lens for detection. The switchable light holes 228 are arranged, and the effect is that when the fluorescence emitted by the sample is strong, the fluorescence can be switched into smaller light holes 228 so as to reduce the light entering quantity of the lens; conversely, when the fluorescence emitted by the sample is weak, the fluorescence can be switched to a larger light hole 228 to increase the light entering amount of the lens. Therefore, different detection requirements are met, and the applicability is wider. In this embodiment, the light hole 228 is a circular hole with a diameter gradually increasing/decreasing along the length direction of the switching hole plate 226. For convenience of switching, it is preferable to select the light holes 228 of different apertures by a touch screen on the housing 100.
In this embodiment, a position sensor 224 for detecting the limit position of the movement of the switching orifice plate 226 is further provided on the side of the detecting element 223 away from the switching motor 221.
Referring to fig. 3, in the present embodiment, a serial interface 180 and a power interface 170 are provided at the rear side of the housing 100, and the detection result can be uploaded through the serial interface 180. The bottom plate of the housing 100 is provided with an MCU 410, a photon counter 420, a first switching power supply 300, a second switching power supply 500, and a third switching power supply 600, respectively. Wherein, the MCU 410 and the photon counter 420 are both mounted on the fixed bracket 400 on the base plate, the first switching power supply 300 is used for supplying power to the MCU 410, the second switching power supply 500 is used for supplying power to the photon counter 420, and the third switching power supply 600 is used for supplying power to and adjusting speed of the centrifugal motor 210. In addition, a radiator 700 for radiating the MCU 410 is further disposed on the bottom plate, and cooling fans 160 are disposed on both sides of the housing 100, so as to improve the heat dissipation capability of the device.
According to the ATP fluorescence detector, the fluorescence quantity of the lens in the detection element can be adjusted according to the fluorescence generation quantity of the sample in the detection chip, so that different detection requirements are met, and the applicability is wide; secondly, the ATP fluorescence detector of the embodiment can realize one-time detection of multiple samples, has high detection efficiency, can detect six groups of samples simultaneously by matching with corresponding microfluidic chips, and has detection flux which is six times that of a commercially available instrument; finally, the detection result can be printed or uploaded in real time by the printing module and the serial interface, and the method is convenient and quick.
The above-described embodiments are merely preferred embodiments for fully explaining the present invention, and the scope of the present invention is not limited thereto. Equivalent substitutions and modifications will occur to those skilled in the art based on the present invention, and are intended to be within the scope of the present invention. The protection scope of the invention is subject to the claims.
Claims (10)
1. An ATP fluorescence detector comprises a shell with an opening at the top, and is characterized in that,
A light-shielding box body is fixedly arranged below the opening on the bottom plate of the shell, a detection position for placing a detection chip is arranged on the light-shielding box body, and a detection hole allowing fluorescence emitted by a sample in the detection chip to pass through is formed in the detection position;
A centrifugal motor and a mounting plate are arranged in the light-shading box body, and the centrifugal motor is used for driving a detection chip on a detection position to carry out centrifugation; the mounting plate is provided with a light hole switching mechanism, the light hole switching mechanism comprises a switching motor and a detection element, the switching motor and the detection element are fixed on the mounting plate, the detection element is used for detecting the fluorescence intensity transmitted through the detection hole, and a lens is arranged on the detection element; a movable switching pore plate is arranged above the detection element, and a plurality of light holes with different sizes are sequentially formed in the switching pore plate along the length direction, and the light holes are used for conducting the light path of the lens;
The switching motor is used for driving the switching pore plate to move along the length direction, and the light inlet quantity of the lens is adjusted by switching different light holes;
The centrifugal motor is characterized in that an optical coupler sensor and a reflecting optical coupler are arranged on the mounting plate, a testing grating is arranged on a spindle of the centrifugal motor, the reflecting optical coupler is matched with the testing grating to be used for testing the rotating speed of the centrifugal motor, and the centrifugal motor is matched with the optical coupler sensor to be used for positioning a detection hole of the chip.
2. The ATP fluorescence detector of claim 1, wherein a gear is fixed on the spindle of the switching motor, a rack engaged with the gear is provided on one side of the switching orifice plate, and the switching motor drives the switching orifice plate to move along the length direction through the gear and the rack.
3. The ATP fluorescence detector of claim 1, wherein the detector element is fixedly provided with a limit bracket, the limit bracket is provided with a chute matched with the switching orifice plate, and the switching orifice plate is slidably connected in the chute.
4. The ATP fluorescence detector of claim 1, wherein the detector element is further provided with a position sensor for detecting a limit position of movement of the switching aperture plate.
5. The ATP fluorescence detector of claim 1, wherein the light-transmitting aperture is a circular aperture with a gradually increasing/decreasing aperture along the length of the switching aperture plate.
6. The ATP fluorescence detector of claim 1, wherein the fixation of the light shielding case and the housing base plate is filled with a light shielding material.
7. The ATP fluorescence detector of claim 6, wherein the light shielding material is light shielding cotton.
8. The ATP fluorescence detector of claim 1, wherein the housing is provided with a display screen and a print module, and a cover plate is hinged to the housing corresponding to the opening.
9. The ATP fluorescence detector of claim 1, wherein the housing is provided with a power interface and a serial interface, and the bottom plate of the housing is provided with an MCU, a photon counter, a first switching power supply for the MCU, a second switching power supply for the photon counter, and a third switching power supply for the centrifugal motor and for speed regulation.
10. The ATP fluorescence detector of claim 9, wherein the bottom plate of the housing is provided with a heat sink for cooling the MCU, and the housing is provided with at least one cooling fan.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811555267.1A CN109520987B (en) | 2018-12-19 | 2018-12-19 | ATP fluorescent detector |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811555267.1A CN109520987B (en) | 2018-12-19 | 2018-12-19 | ATP fluorescent detector |
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| CN109520987A CN109520987A (en) | 2019-03-26 |
| CN109520987B true CN109520987B (en) | 2024-07-12 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112881305B (en) * | 2021-01-14 | 2022-11-25 | 河南天子铝业有限公司 | Rapid detection equipment for aluminum profile |
| CN116609314B (en) * | 2023-07-19 | 2023-09-26 | 武汉睿奇生物工程有限公司 | Fluorescence detector |
| CN117571656B (en) * | 2023-11-22 | 2024-05-03 | 无锡迅杰光远科技有限公司 | High-precision switching spectrum acquisition system |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| CN104630373A (en) * | 2015-02-13 | 2015-05-20 | 博奥生物集团有限公司 | Rapid parallel nucleic acid detection method and system based on micro-fluidic chip |
| CN209946007U (en) * | 2018-12-19 | 2020-01-14 | 苏州汶颢微流控技术股份有限公司 | ATP fluorescence detector |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JPH0621862B2 (en) * | 1990-07-10 | 1994-03-23 | 海洋科学技術センター | Ocean laser observation system using multi-phenomenon simultaneous photometry |
| JP3639855B2 (en) * | 1998-10-30 | 2005-04-20 | 理学電機工業株式会社 | X-ray fluorescence analyzer |
| JP3572333B2 (en) * | 1998-12-28 | 2004-09-29 | 理学電機工業株式会社 | X-ray fluorescence analyzer |
| CN1987430B (en) * | 2006-12-20 | 2011-01-12 | 东华大学 | Integrated multi-function chip instrument |
| JP5321402B2 (en) * | 2008-10-14 | 2013-10-23 | 日本精工株式会社 | Centrifuge microscope |
| KR101188217B1 (en) * | 2009-11-26 | 2012-10-09 | (주)이빛 | Portable spectroscopic analyzing apparatus |
| EP2666402B1 (en) * | 2011-01-20 | 2020-04-15 | VS Technology Corporation | A light source device having an illumination aperture diaphragm |
| CN205067345U (en) * | 2015-09-29 | 2016-03-02 | 西安工程大学 | Desk -top ATP fluorescence detector with rotatory swab cabin |
| CN106222069B (en) * | 2016-08-31 | 2018-11-09 | 上海科源电子科技有限公司 | A kind of disc-type chip PCR instrument and detection method |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR19990012427U (en) * | 1997-09-09 | 1999-04-06 | 이해규 | Camera aperture adjustment |
| CN104630373A (en) * | 2015-02-13 | 2015-05-20 | 博奥生物集团有限公司 | Rapid parallel nucleic acid detection method and system based on micro-fluidic chip |
| CN209946007U (en) * | 2018-12-19 | 2020-01-14 | 苏州汶颢微流控技术股份有限公司 | ATP fluorescence detector |
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