CN109406732B - Dynamic degradation device and monitoring system for degradable biological material - Google Patents
Dynamic degradation device and monitoring system for degradable biological material Download PDFInfo
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- CN109406732B CN109406732B CN201811486878.5A CN201811486878A CN109406732B CN 109406732 B CN109406732 B CN 109406732B CN 201811486878 A CN201811486878 A CN 201811486878A CN 109406732 B CN109406732 B CN 109406732B
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- 239000012620 biological material Substances 0.000 title claims abstract description 89
- 238000012544 monitoring process Methods 0.000 title claims abstract description 24
- 238000006731 degradation reaction Methods 0.000 title claims abstract description 21
- 230000015556 catabolic process Effects 0.000 title claims abstract description 20
- 238000012360 testing method Methods 0.000 claims abstract description 393
- 238000000034 method Methods 0.000 claims abstract description 78
- 230000008569 process Effects 0.000 claims abstract description 71
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 48
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- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 33
- 239000001257 hydrogen Substances 0.000 claims description 33
- 229910052739 hydrogen Inorganic materials 0.000 claims description 33
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
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- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
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- Investigating Or Analysing Biological Materials (AREA)
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Abstract
The invention provides a dynamic degradation device and a monitoring system for a degradable biological material, wherein the time length of each test stage, the addition amount of each reagent, the addition time point of each reagent, the reaction time length and the preset amount of overflow gas are preset through a test host. The camera assembly height and the gas sensor height are adjusted. The test host acquires the preset duration of each test stage, the preset PH value of the test reagent, the temperature of the test reagent and the flow rate and flow velocity of the test reagent, acquires the internal image change of the test host, and compares the internal image change with a preset threshold value; and storing the test process data, and transmitting the test process data and the test result data to a test server test host to store the test process data for the test personnel to inquire. In the test process, test personnel can also adjust test parameters in real time through the test host computer and perform operation, so that test requirements are met.
Description
Technical Field
The invention relates to the field of degradable biological material experiments, in particular to a degradable biological material dynamic degradation device and a monitoring system.
Background
The degradable biological material such as certain metal and macromolecule implantation products can have different influences on the degradation time and the surrounding environment of the products due to different implantation positions, different stress, different degradation mechanisms and the like in the degradation process of human bodies.
The medical biodegradable material is mainly used for human bodies, is directly related to life and health of the human bodies, and has no toxic or side effect. The method requires high material purity, very clean production environment, less auxiliary agent residue and impurity content of ppm level, and ensures no disease and no toxic transmission condition. While the compounds themselves and monomeric impurities, degradation or abrasion products do not adversely affect the body. The physical, chemical and mechanical properties are required to meet the requirements of the design and function required by the medical use. Such as hardness, elasticity, mechanical strength, fatigue strength, creep, abrasion, water absorption, dissolution, enzyme resistance, in vivo aging, and the like. For example, heart valves are preferably used for 25 ten thousand hours, and particularly good fatigue strength is required. In addition, it is also required to facilitate sterilization, to withstand wet heat sterilization (120-140 ℃), dry heat sterilization (160-190 ℃), radiation sterilization or chemical treatment sterilization without degrading the properties of the material. Medical polymer materials with different properties can be sterilized in a proper mode according to specific conditions. Can have certain in vivo adaptability: including compatibility with other materials in medical supplies, biocompatibility, blood compatibility and tissue compatibility of materials with the human body. After the material is implanted into a human body, the material is required to have no influence on body fluid for a long time. The artificial kidney filtration membrane and the artificial lung gas exchange membrane each having a separation dialysis function, and the artificial blood gas-absorbing and desorbing substances and the like are required to have specific separation permeation functions.
After the medical biodegradable material is implanted into a human body, the PH value of the human body part has certain hydrogen evolution corrosion to the medical polymer material, namely the PH value in the human body has great influence on the hydrogen evolution corrosion speed, and the corrosion speed is rapidly increased along with the decrease of the PH value, so that the hydrogen evolution reaction is promoted. The PH decreased and Eec shifted forward, increasing the tendency to corrosion. Thus not only affecting the use of medical biodegradable materials, but also easily causing harm to human bodies.
At present, before the medical biodegradable material is used, the medical biodegradable material which is easy to generate hydrogen evolution corrosion needs to be tested, and the use performance of the medical biodegradable material is analyzed. The current medical biodegradable material test is carried out only manually by adjusting the reagent in a test tube. The test time, the usage amount of the metering reagent, the test process data and the like are manually metered, so that not only the test precision is affected, but also the test process data and the result data are manually recorded.
In addition, the current test process is carried out singly, namely the operation process of each experiment is carried out independently, each experiment process can not be recorded manually if mutual comparison and reference are needed, one comparison is carried out after the test is completed, and the data information of the experiment process can not be compared in the test process. Some tests need to be repeated for a plurality of times under different use environments or different external environments, and in this case, the comparison of the test process data can only be performed after the test is completed, so that the real-time comparison and analysis of the test process data cannot be performed.
Disclosure of Invention
In order to overcome the defects in the prior art, the invention provides a dynamic degradation device and a monitoring system for a degradable biological material, comprising: the test device comprises a plurality of test devices, wherein each test device is connected with a test host; each test host is connected with a test server;
the test device is provided with a PH value monitor, a PH value alarm, an experiment backboard, an experiment tube body, an opening at the upper part of the experiment tube body, a substrate, a vibration disc seat, a table top and a table top, wherein the substrate is fixedly connected with the bottom of the substrate; a pulse electromagnet is arranged in the vibration disc seat;
the side part of the experimental tube body is provided with a camera shooting component; the camera component is used for shooting color change of substances in the experimental tube body; the PH value monitor monitors the PH value in the experimental tube body;
the upper part of the opening of the experimental tube body is provided with a gas sensor which is connected with a connecting component; the side wall of the experimental tube body is provided with a plurality of infusion interfaces;
the test host is connected with a display screen, a PH value monitor, a gas sensor, a pulse electromagnet and a camera shooting assembly are respectively connected with the test host, the test host acquires gas data information emitted by the test tube body in real time through the gas sensor, acquires test process information and test result information of substances in the test tube body through the camera shooting assembly, acquires PH value information in the test tube body through the PH value monitor, and displays the PH value information through the display screen; when the PH value exceeds the threshold value, an alarm prompt is sent out through a PH value alarm;
The test host controls the running of the pulse electromagnet through the pulse electromagnet, so that the pulse electromagnet drives the vibration disc seat to vibrate, drives the test tube body to vibrate, and promotes the mixing of substances in the test tube body;
the test host is used for acquiring the preset duration of each test stage, the preset PH value of the test reagent, the temperature of the test reagent and the flow rate and flow velocity of the test reagent, acquiring the internal image change of the test host and comparing the internal image change with a preset threshold value; and storing the test process data and transmitting the test process data and the test result data to a test server.
Preferably, the test server is used for acquiring test process data and test result data transmitted by each test host, so that each test host forms a trend analysis chart along with time evolution based on the change generated by the tested substances in the test process, and performs early warning and monitoring according to a preset threshold value; the method is also used for transversely comparing the current test data with the past test data to form a comparison trend chart;
the device is also used for configuring at least two test devices according to preset test requirements to perform test operation with the same test requirements; in the test process, a test server acquires test process data with the same test requirement in real time, and performs one-to-one comparison on the same degradable biological material state based on the same test material in the same time period;
And is also used for comparison display based on the reaction state of the degradable biological material under the conditions of different temperatures or different reaction additives.
Preferably, the test server is further configured to provide a test setting module for each of the degradable biological material test items, and the user configures each of the degradable biological material test items in a search, modification and deletion operation manner provided by the test setting module;
the personnel test setting module is also used for providing a degradable biological material test item corresponding to each tester, and the test item corresponding to the tester is configured and monitored by the inspection, modification and deletion operation mode provided by the personnel test setting module by each tester;
and the degradable biological material test setting module is also used for providing each degradable biological material, and a user performs the operation of checking, modifying and deleting on the basis of the test of each degradable biological material through the degradable biological material test setting module so as to realize the configuration and monitoring on the basis of the test process of each degradable biological material.
Preferably, the test device is also provided with peristaltic pumps with the quantity matched with that of the infusion interface;
each peristaltic pump is respectively connected with a test host, and the test host respectively controls the operation of each peristaltic pump;
Every two peristaltic pumps form a circulating liquid pump group;
one end of the peristaltic pump is connected with the test liquid interface through a silica gel tube, and the other end of the peristaltic pump is connected with the liquid outlet of the experimental reagent storage container; the other test liquid interface of the test tube body is connected with the inlet of the test reagent storage container through a silicone tube and a peristaltic pump to form a loop; the peristaltic pump is used for driving the test reagent in the test reagent storage container into the test tube body under the driving of the control host, and the peristaltic pump arranged at the inlet side of the test reagent storage container drives the test reagent in the test tube body to flow out, so that the test reagent in the test tube body circularly flows and the body fluid flow of a human body is simulated;
a flowmeter and a flow control valve are also arranged between the peristaltic pump and the test liquid interface;
the flowmeter and the flow control valve are respectively connected with the control host, and the control host controls the on-off of the flow control valve and obtains the flow of the test liquid added into the experimental tube body through the flowmeter.
Preferably, the upper part of the base plate is connected with an infrared heating ring which is surrounded outside the experimental tube body and is provided with a distance from the outer wall of the experimental tube body;
further comprises: a temperature sensor inserted into the experimental tube;
The infrared heating ring and the temperature sensor are respectively connected with a test host, and the test host controls the operation of the infrared heating ring and acquires the internal temperature information of the test tube through the temperature sensor.
Preferably, the camera assembly includes: the camera comprises a camera base, a telescopic rod and a camera;
the camera shooting base is provided with a rotating motor, and an output shaft of the rotating motor is connected with a driving gear;
the bottom of the telescopic rod is provided with a linkage gear, the linkage gear is connected with a base rod, a rack is arranged in the base rod, and the inside of the base rod is connected with a push rod through the rack; the push rod is connected with a push rod motor; the top end of the push rod is connected with the camera;
the linkage gear is meshed with the driving gear, the rotating motor drives the driving gear to rotate, the linkage gear is driven to rotate, and the horizontal angle of the camera is adjusted;
the push rod motor drives the push rod to move up and down along the rack inside the base rod, and the height of the camera is adjusted.
Preferably, the method further comprises: a cleaning machine for cleaning the experimental equipment; the cleaning machine is provided with a shell, and the shell is made of heat insulation materials; the shell is hinged with a door body, the door body is connected with the shell in a sealing way, and a safety lock is arranged between the door body and the shell;
the bottom of the shell is connected with a support, a cleaning table is arranged in the shell, and a heating device and a lower water spraying hole are arranged at the bottom of the cleaning table; the top of the cleaning table is provided with an upper water spraying device; a floating control valve is also arranged on the cleaning table; the bottom of the shell is also provided with a drain pipe which is connected with a draining tank; the draining tank is arranged at the lower part of the table top;
The surface of the shell is provided with a cleaning control button and a cleaning agent adding hole.
Preferably, the test host is further used for presetting a central line coordinate of the test tube body, and presetting a rectangular area for configuring the degradable biological material hydrogen evolution test image to uniformly extend along the central line of the test tube body to two sides; configuring preset layering heights of layering each substance in the experimental tube body before or after reaction according to experimental requirements, and presetting layering images based on each layering height;
acquiring video information shot by a camera, separating the video information into degradable biological material hydrogen evolution experimental image data of each frame of image, and judging whether the central line coordinates of an experimental tube in the degradable biological material hydrogen evolution experimental image data are matched with the central line coordinates of the experimental tube in a preset degradable biological material hydrogen evolution experimental image or not when the degradable biological material hydrogen evolution experimental image data are displayed; if the two images are matched, obtaining degradable biological material hydrogen evolution experimental image data, searching layered images in the experimental process based on pixel differences of the degradable biological material hydrogen evolution experimental image data, searching boundaries of the degradable biological material hydrogen evolution experimental image, dividing the layered images, comparing the layered images with preset layered images to judge whether the sizes are the same, if the sizes are the same, configuring the current layered image as an experimental process image analysis area, and obtaining images of color changes, sediment changes and liquid level height changes of substances in an experimental tube body in the experimental process.
Preferably, the test server is further used for sending a screenshot instruction for capturing video images of the test process to the test host according to a control instruction of a tester, or according to a preset time point, or according to the setting of the stage point of the test process; and receiving a screenshot sent by the test host, and grabbing a test substance state image in the layered image for storage and display.
Preferably, the connection assembly comprises: a sensor base, a sensor telescopic rod and a crank rod;
the sensor base is provided with a sensor rotating motor, and an output shaft of the sensor rotating motor is connected with a sensor driving gear; the bottom of the sensor telescopic rod is provided with a sensor linkage gear, the sensor linkage gear is connected with a sensor base rod, a rack is arranged in the sensor base rod, and the sensor base rod is connected with a sensor push rod through the rack; the sensor push rod is connected with a sensor push rod motor; the top end of the sensor push rod is hinged with one end of the turning rod; the other end of the crank rod is connected with a gas sensor;
the sensor linkage gear is meshed with the sensor driving gear, the sensor rotating motor drives the sensor driving gear to rotate, the sensor linkage gear is driven to rotate, and the horizontal angle of the gas sensor is adjusted;
The sensor push rod motor drives the sensor push rod to move up and down along the rack inside the sensor base rod, and the height of the gas sensor is adjusted.
Preferably, the top of the experiment backboard is provided with a top illuminating lamp, and one side of the experiment backboard is provided with a side illuminating lamp; the top illuminating lamp and the side illuminating lamp are respectively connected with the test host;
the test area is also provided with an ambient temperature sensor, an ambient humidity sensor and an ambient illuminance sensor;
the environment temperature sensor, the environment humidity sensor and the environment illuminance sensor are respectively connected with the test host, the test host sequentially acquires the environment temperature information, the environment humidity information and the environment illuminance information through the environment temperature sensor, the environment humidity information and the environment illuminance sensor, and when the environment temperature information, the environment humidity information and the environment illuminance information are not consistent with preset environment condition information required by the current test, the test host controls the environment temperature through controlling an air conditioner of a laboratory, controls the environment humidity through a humidifier and a dehumidifier of the laboratory, and controls illuminance of a test area through respectively controlling a switch of a top lighting lamp and a side lighting lamp.
From the above technical scheme, the invention has the following advantages:
according to the invention, the test server acquires test process data and test result data transmitted by each test host, so that each test host forms a trend analysis chart along with time evolution based on the change generated by the tested substances in the test process, and early warning and monitoring are carried out according to a preset threshold value; the method is also used for transversely comparing the current test data with the past test data to form a comparison trend chart;
according to the preset test requirements, configuring at least two test devices to perform test operation with the same test requirements; in the test process, a test server acquires test process data with the same test requirement in real time, and performs one-to-one comparison on the same degradable biological material state based on the same test material in the same time period; and is also used for comparison display based on the reaction state of the degradable biological material under the conditions of different temperatures or different reaction additives.
The test procedure can be based on repeated tests performed in different use environments or different external environments, and comparison analysis of test procedure data is performed during the test procedure. The test personnel can adjust test parameters according to the test process, and the test requirements and demands are met.
According to the use function, use environment, use condition and other factors of the degradable biological material for the test, the time length of each test stage preset by the test host, the addition amount of each reagent, the addition time point of each reagent, the reaction time length and the preset amount of the overflow gas. The camera assembly height and the gas sensor height are adjusted. The degradable biological material to be tested is placed into the test tube body from the opening in the upper portion of the test tube body. According to the preset test using reagent and the adding amount of each reagent, the adding time is controlled by a test host, and the color change of the reagent in the test tube body is obtained through a camera assembly and recorded. And simultaneously sensing the overflowed gas in the test process by a gas sensor, and acquiring the quantity of the overflowed gas. The test host stores test process data for test personnel to inquire. In the test process, test personnel can also adjust test parameters in real time through the test host computer and perform operation, so that test requirements are met.
Drawings
FIG. 1 is a schematic diagram of a degradable biological material dynamic degradation device and a monitoring system;
FIG. 2 is a schematic diagram of a test host connected to a test server;
FIG. 3 is a schematic diagram of the test apparatus.
Fig. 4 is a schematic diagram of a camera assembly.
Fig. 5 is a schematic view of a cleaning machine.
Detailed Description
The invention provides a degradable biological material dynamic degradation device and a monitoring system, as shown in figures 1 to 4, comprising: a plurality of test devices 1, each test device 1 being connected to a test host 2; each test host 2 is connected with a test server 3;
the test device 1 is provided with a PH value monitor, a PH value alarm, an experiment backboard 4, an experiment tube body 5 arranged at the front part of the experiment backboard 4, an opening at the upper part of the experiment tube body 5, a base plate 27 arranged at the bottom of the experiment tube body 5, a vibration disc seat 26 fixedly connected with the bottom of the base plate 27, and a table top 1 fixedly connected with the bottom of the vibration disc seat 26; a pulse electromagnet is arranged inside the vibration disc seat 26;
the side part of the experimental tube body 5 is provided with a camera shooting component; the camera shooting component is used for shooting color change of substances in the experimental tube body 5; the PH value monitor monitors the PH value in the experimental tube body 5;
the upper part of the opening of the experimental tube body 5 is provided with a gas sensor 21, and the gas sensor 21 is connected with a connecting component; the side wall of the experimental tube body 5 is provided with a plurality of infusion interfaces 7;
the test host is connected with a display screen, a PH value monitor, a gas sensor 21, a pulse electromagnet and a camera shooting assembly are respectively connected with the test host, the test host acquires gas data information emitted by the test tube body 5 in real time through the gas sensor 21, acquires test process information and test result information of substances in the test tube body 5 through the camera shooting assembly, acquires PH value information in the test tube body 5 through the PH value monitor and displays the information through the display screen; when the PH value exceeds the threshold value, an alarm prompt is sent out through a PH value alarm;
The test host controls the running of the pulse electromagnet through the pulse electromagnet, so that the pulse electromagnet drives the vibration disc seat 26 to vibrate, drives the test tube body 5 to vibrate, and promotes substances in the test tube body 5 to be mixed;
the test host is used for obtaining the preset duration of each test stage, the preset PH value of the test reagent, the temperature of the test reagent and the flow rate and flow velocity of the test reagent, obtaining the internal image change of the test tube body (5) and comparing the internal image change with a preset threshold value; the test process data are stored and also transmitted to the test server 3.
It will be understood that when an element or layer is referred to as being "on" or "connected" or "coupled" to another element or layer, it can be directly on, connected or coupled to the other element or layer, or intervening elements or layers may also be present. In contrast, when an element is referred to as being "directly on," "directly connected to" or "directly coupled to" another element or layer, there are no intervening elements or layers present. Like numbers refer to like elements throughout. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.
According to the use function, use environment, use condition and other factors of the degradable biological material for the test, the invention presets the duration of each test stage, the addition amount of each reagent, the addition time point of each reagent, the reaction duration and the preset amount of the overflow gas through the test host. The camera assembly height and the gas sensor height are adjusted. The degradable biological material to be tested is put into the test tube 5 from the opening in the upper part of the test tube 5. According to the preset test using reagent and the adding amount of each reagent, the adding time is controlled by a test host, and the color change of the reagent in the test tube body is obtained through a camera assembly and recorded. And simultaneously sensing the overflowed gas in the test process by a gas sensor, and acquiring the quantity of the overflowed gas. The test host stores test process data for test personnel to inquire. In the test process, test personnel can also adjust test parameters in real time through the test host computer and perform operation, so that test requirements are met.
In the invention, the test server 3 is used for acquiring the data of the transmission test process and the test result data of each test host 2, so that each test host 2 forms a time evolution trend analysis chart based on the change generated by the tested substances in the test process, and performs early warning and monitoring according to a preset threshold value; the method is also used for transversely comparing the current test data with the past test data to form a comparison trend chart;
The device is also used for configuring at least two test devices 1 according to preset test requirements to perform test operation with the same test requirements; in the test process, the test server 3 acquires test process data with the same test requirement in real time, and performs one-to-one comparison on the same degradable biological material state based on the same test material in the same time period;
and is also used for comparison display based on the reaction state of the degradable biological material under the conditions of different temperatures or different reaction additives.
According to the invention, due to the test purpose of the degradable biological material, the requirements of the degradable biological material are different in test reagents required in the test process of the degradable biological material, initial test conditions can be configured through the test server, and the initial test conditions are configured to each test host to execute the test process.
The invention can realize the simultaneous and synchronous test based on the test purpose of the same degradable biological material or the requirement of the degradable biological material, and can perform the comparison of the test data process and the comparison and analysis of the data of the past test process in real time to assist the testers.
In the invention, the test server 3 is also used for providing a test setting module of each degradable biological material test item, and a user configures each degradable biological material test item through a search, modification and deletion and addition operation mode provided by the test setting module;
The personnel test setting module is also used for providing a degradable biological material test item corresponding to each tester, and the test item corresponding to the tester is configured and monitored by the inspection, modification and deletion operation mode provided by the personnel test setting module by each tester;
and the degradable biological material test setting module is also used for providing each degradable biological material, and a user performs the operation of checking, modifying and deleting on the basis of the test of each degradable biological material through the degradable biological material test setting module so as to realize the configuration and monitoring on the basis of the test process of each degradable biological material.
The test personnel can conveniently configure and operate the test. The test conditions can also be set according to different requirements and demands.
In the invention, the test device 1 is also provided with peristaltic pumps 17 with the quantity matched with the infusion interface 7;
each peristaltic pump 17 is respectively connected with a test host, and the test host respectively controls the operation of each peristaltic pump 17;
every two peristaltic pumps 17 form a circulating liquid pump group;
one end of the peristaltic pump 17 is connected with the test liquid interface 7 through a silica gel tube, and the other end of the peristaltic pump 17 is connected with a liquid outlet of the test reagent storage container; the other test liquid interface 7 of the test tube body 5 is connected with the inlet of the test reagent storage container through a silicone tube and a peristaltic pump to form a loop; the peristaltic pump is used for driving the test reagent in the test reagent storage container into the test tube body 5 under the driving of the control host, and the peristaltic pump arranged at the inlet side of the test reagent storage container drives the test reagent in the test tube body 5 to flow out, so that the test reagent in the test tube body 5 circularly flows and the body fluid flow of a human body is simulated;
A flowmeter and a flow control valve are also arranged between the peristaltic pump 17 and the test liquid interface 7; the flowmeter and the flow control valve are respectively connected with a control host, and the control host controls the on-off of the flow control valve and obtains the flow of the test liquid added into the experimental tube body 5 through the flowmeter.
In the invention, an infrared heating ring is connected to the upper part of a base plate 27, the infrared heating ring is surrounded outside an experimental tube body 5, and a distance is arranged between the infrared heating ring and the outer wall of the experimental tube body 5; further comprises: a temperature sensor inserted into the experimental tube body 5; the infrared heating ring and the temperature sensor are respectively connected with a test host, and the test host controls the operation of the infrared heating ring and acquires the internal temperature information of the test tube body 5 through the temperature sensor. The temperature sensor can be inserted manually, or can be provided with a structure such as a connecting component or a camera shooting component for controlling and driving.
In the present invention, an image pickup assembly includes: a camera base 10, a telescopic rod 9 and a camera 8;
the imaging base 10 is provided with a rotating motor 31, and an output shaft of the rotating motor 31 is connected with a driving gear 32;
the bottom of the telescopic rod 9 is provided with a linkage gear 33, the linkage gear 33 is connected with a base rod, a rack is arranged in the base rod, and a push rod is connected in the base rod through the rack; the push rod is connected with a push rod motor; the top end of the push rod is connected with a camera 8;
The driving gear 33 is meshed with the driving gear 32, the rotating motor 31 drives the driving gear 32 to rotate, the driving gear 33 is driven to rotate, and the horizontal angle of the camera 8 is adjusted; the push rod motor drives the push rod to move up and down along the rack inside the base rod, and the height of the camera 8 is adjusted.
The interlocking gear 33 and the driving gear 32 are meshed with each other, so that the horizontal angle of the camera 8 can be accurately adjusted, and the push rod motor drives the push rod to move up and down along the rack inside the base rod, so that the acquisition of image information in the experimental process is ensured. The height and angle may also be set as desired.
The camera 8 can capture image information of the medium in the experimental tube body, such as liquid color information, liquid layering information, height information of each layer after liquid layering, reaction information in the experimental process, precipitation information and the like. If the test has a certain explosion risk, the test personnel can be far away from the test site, the change can be observed remotely without approaching, and the risk degree can be searched.
Spatially relative terms, such as "under" …, "below," "lower," "above," "over" and the like, may be used herein to describe one element or feature's relationship to another element or feature as illustrated in the figures. It will be understood that the spatially relative terms are intended to encompass different orientations of the device in use or operation in addition to the orientation depicted in the figures. For example, if the device in the figures is turned over, elements described as "under" or "beneath" other elements or features would then be oriented "over" the other elements or features. Thus, the exemplary term "below" may include both an orientation above and below. Other orientations of the device (90 degrees or other orientations) are possible, and spatially relative descriptors used herein interpreted accordingly.
In the invention, the test host is also used for presetting the central line coordinate of the test tube body 5, and presetting a rectangular area which is formed by configuring the degradable biological material hydrogen evolution test image to uniformly extend along the central line of the test tube body to two sides; configuring preset layering heights of layering each substance in the experimental tube body before or after reaction according to experimental requirements, and presetting layering images based on each layering height;
acquiring video information shot by a camera 8, separating the video information into degradable biological material hydrogen evolution experimental image data of each frame of image, and judging whether the central line coordinate of the experimental tube body 5 in the degradable biological material hydrogen evolution experimental image data is matched with the central line coordinate of the experimental tube body 5 in a preset degradable biological material hydrogen evolution experimental image when the degradable biological material hydrogen evolution experimental image data is displayed; if the two images are matched, obtaining degradable biological material hydrogen evolution experimental image data, searching layered images in the experimental process based on pixel differences of the degradable biological material hydrogen evolution experimental image data, searching boundaries of the degradable biological material hydrogen evolution experimental image, dividing the layered images, comparing the layered images with preset layered images to judge whether the sizes are the same, if the sizes are the same, configuring the current layered image as an experimental process image analysis area, and obtaining images of color changes, sediment changes and liquid level height changes of substances in an experimental tube body in the experimental process.
The center line coordinates are set according to the test requirement, and the degradable biological material hydrogen evolution test image is provided with rectangular areas which uniformly extend along the center line of the test tube body to two sides, wherein one or more rectangular areas can be arranged. The situation that the layering occurs due to the fact that different liquid media are not compatible, the layering is possibly broken in the experimental process, layering is carried out again or layering is not carried out, color change, solid-liquid conversion, liquid-solid conversion and the like can be generated, after the image is obtained, effective image data can be analyzed and extracted based on the change of the image by a processor of the experimental host, the effective image data is displayed, and the automatic analysis performance of the experimental process data is improved.
The experimental process video acquired in real time is sliced into a plurality of images, the images are displayed and analyzed, and then the fact that the central line coordinates of the experimental tube body 5 in the data of the experimental image of the hydrogen evolution of the degradable biological material is not matched with the central line coordinates of the experimental tube body 5 in the preset experimental image of the hydrogen evolution of the degradable biological material is judged, so that the central line coordinates of the experimental tube body 5 in the data of the experimental image of the hydrogen evolution of the degradable biological material are matched with the central line coordinates of the experimental tube body 5 in the preset experimental image of the hydrogen evolution of the degradable biological material by adjusting the height and the angle of the camera 8.
The test server 3 is further used for sending a screenshot instruction for capturing video images of the test process to the test host according to a control instruction of a tester, or according to a preset time point, or according to the setting of the stage point of the test process; and receiving a screenshot sent by the test host, and grabbing a test substance state image in the layered image for storage and display.
In the present invention, the connection assembly includes: a sensor base 35, a sensor telescopic rod 9 and a crank 36;
the sensor base 35 is provided with a sensor rotating motor, and an output shaft of the sensor rotating motor is connected with a sensor driving gear; the bottom of the sensor telescopic rod 9 is provided with a sensor linkage gear, the sensor linkage gear is connected with a sensor base rod, a rack is arranged in the sensor base rod, and a sensor push rod is connected in the sensor base rod through the rack; the sensor push rod is connected with a sensor push rod motor; the top end of the sensor push rod is hinged with one end of the crank rod 36; the other end of the crank lever 36 is connected with the gas sensor 21;
the sensor linkage gear is meshed with the sensor driving gear, the sensor rotating motor drives the sensor driving gear to rotate, the sensor linkage gear is driven to rotate, and the horizontal angle of the gas sensor 21 is adjusted; the sensor push rod motor drives the sensor push rod to move up and down along the rack inside the sensor base rod, and the height of the gas sensor 21 is adjusted.
The sensor linkage gear and the sensor driving gear are meshed with each other, so that the horizontal angle of the gas sensor can be accurately adjusted, and the sensor push rod motor drives the sensor push rod to move up and down along the rack inside the sensor base rod, and the sensitivity and accuracy of the gas sensor in the experimental process are ensured. The height and angle may also be set as desired.
In the invention, a top illuminating lamp is arranged at the top of the experiment backboard 4, and a side illuminating lamp 12 is arranged at one side of the experiment backboard 4; the top illuminating lamp and the side illuminating lamp 12 are respectively connected with the test host; the test area is also provided with an ambient temperature sensor, an ambient humidity sensor and an ambient illuminance sensor; the environment temperature sensor, the environment humidity sensor and the environment illuminance sensor are respectively connected with the test host, the test host sequentially acquires the environment temperature information, the environment humidity information and the environment illuminance information through the environment temperature sensor, the environment humidity information and the environment illuminance sensor, and when the environment temperature information, the environment humidity information and the environment illuminance information are not consistent with preset environment condition information required by the current test, the test host controls the environment temperature through controlling an air conditioner of a laboratory, controls the environment humidity through a humidifier and a dehumidifier of the laboratory, and controls illuminance of a test area through respectively controlling a switch of the top lighting lamp and the side lighting lamp 12.
In the present invention, as shown in fig. 5, the method further comprises: a cleaning machine for cleaning the experimental equipment; the cleaning machine is provided with a shell 51, and the shell 51 is made of heat insulation materials; the shell 51 is hinged with a door body 52, the door body 52 is connected with the shell 51 in a sealing way, and a safety lock is arranged between the door body 52 and the shell 51;
the bottom of the shell 51 is connected with a support 59, a cleaning table 60 is arranged in the shell 51, and a heating device 54 and a lower water spray hole 55 are arranged at the bottom of the cleaning table 60; the top of the cleaning table 60 is provided with an upper water spraying device 53; the cleaning table 60 is also provided with a floating control valve; a drain pipe 56 is also arranged at the bottom of the shell 51, and the drain pipe 56 is connected with a draining tank; the draining tank is arranged at the lower part of the table top;
the housing 51 has a cleaning control button and a cleaning agent addition hole 57 provided on the surface thereof.
In the invention, at least two fixed buckles 6 are connected to the experimental backboard 4, the fixed buckles 6 are connected to the experimental backboard 4 in a vertical mode, and the fixed buckles 6 are encircling the outside of the experimental pipe body 5, so that the experimental pipe body 5 is stably arranged.
The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (10)
1. A degradable biological material dynamic degradation device and a monitoring system, which is characterized by comprising: a plurality of test devices (1), each test device (1) being connected with a test host (2); each test host (2) is connected with a test server (3);
the test device (1) is provided with a PH value monitor, a PH value alarm and an experiment backboard (4), the front part of the experiment backboard (4) is provided with an experiment tube body (5), the upper part of the experiment tube body (5) is provided with an opening, the bottom of the experiment tube body (5) is provided with a base plate (27), the bottom of the base plate (27) is fixedly connected with a vibration disc seat (26), and the bottom of the vibration disc seat (26) is fixedly connected with the table top (1); a pulse electromagnet is arranged in the vibration disc seat (26);
the side part of the experimental tube body (5) is provided with a camera shooting component; the camera shooting component is used for shooting color change of substances in the experimental tube body (5); the PH value monitor monitors the PH value in the experimental tube body (5);
the upper part of the opening of the experimental tube body (5) is provided with a gas sensor (21), and the gas sensor (21) is connected with a connecting component; a plurality of transfusion interfaces (7) are arranged on the side wall of the experimental tube body (5);
the test host is connected with a display screen, a PH value monitor, a gas sensor (21), a pulse electromagnet and a camera shooting assembly are respectively connected with the test host, the test host acquires gas data information emitted by the test tube body (5) in real time through the gas sensor (21), acquires test process information and test result information of substances in the test tube body (5) through the camera shooting assembly, acquires PH value information in the test tube body (5) through the PH value monitor, and displays the information through the display screen; when the PH value exceeds the threshold value, an alarm prompt is sent out through a PH value alarm;
The test host controls the running of the pulse electromagnet through the pulse electromagnet, so that the pulse electromagnet drives the vibration disc seat (26) to vibrate, drives the test tube body (5) to vibrate, and promotes substances in the test tube body (5) to be mixed;
the test host is used for obtaining the preset duration of each test stage, the preset PH value of the test reagent, the temperature of the test reagent and the flow rate and flow velocity of the test reagent, obtaining the internal image change of the test tube body (5) and comparing the internal image change with a preset threshold value; test process data are stored and are also transmitted to a test server (3).
2. The dynamic degradation device and monitoring system for degradable biological material according to claim 1, wherein,
the test server (3) is used for acquiring test process data and test result data transmitted by each test host (2), so that each test host (2) forms a time evolution trend analysis chart based on the change generated by the tested substances in the test process, and performs early warning and monitoring according to a preset threshold value; the method is also used for transversely comparing the current test data with the past test data to form a comparison trend chart;
the device is also used for configuring at least two test devices (1) according to preset test requirements to perform test operation with the same test requirements; in the test process, a test server (3) acquires test process data with the same test requirement in real time, and performs one-to-one comparison on the same degradable biological material state based on the same test material in the same time period;
And is also used for comparison display based on the reaction state of the degradable biological material under the conditions of different temperatures or different reaction additives.
3. The dynamic degradation device and monitoring system for degradable biological material according to claim 1 or 2, wherein,
the test server (3) is also used for providing a test setting module of each degradable biological material test item, and a user configures each degradable biological material test item through a search, modification and deletion and addition operation mode provided by the test setting module;
the personnel test setting module is also used for providing a degradable biological material test item corresponding to each tester, and the test item corresponding to the tester is configured and monitored by the inspection, modification and deletion operation mode provided by the personnel test setting module by each tester;
and the degradable biological material test setting module is also used for providing each degradable biological material, and a user performs the operation of checking, modifying and deleting on the basis of the test of each degradable biological material through the degradable biological material test setting module so as to realize the configuration and monitoring on the basis of the test process of each degradable biological material.
4. The dynamic degradation device and monitoring system for degradable biological material according to claim 1 or 2, wherein,
The test device (1) is also provided with peristaltic pumps (17) the number of which is matched with that of the infusion interfaces (7);
each peristaltic pump (17) is respectively connected with a test host, and the test host respectively controls the operation of each peristaltic pump (17);
every two peristaltic pumps (17) form a circulating liquid pump group;
one end of a peristaltic pump (17) is connected with the test liquid interface (7) through a silica gel tube, and the other end of the peristaltic pump (17) is connected with a liquid outlet of the test reagent storage container; the other test liquid interface (7) of the test tube body (5) is connected with the inlet of the test reagent storage container through a silicone tube and a peristaltic pump, and a loop is formed; the peristaltic pump is used for driving the test reagent in the test reagent storage container into the test tube body (5) under the driving of the control host, and the peristaltic pump arranged at the inlet side of the test reagent storage container drives the test reagent in the test tube body (5) to flow out, so that the test reagent in the test tube body (5) circularly flows to simulate the body fluid flow of a human body;
a flowmeter and a flow control valve are also arranged between the peristaltic pump (17) and the test liquid interface (7);
the flowmeter and the flow control valve are respectively connected with the control host, and the control host controls the on-off of the flow control valve and obtains the flow of the test liquid added into the experimental tube body (5) through the flowmeter.
5. The dynamic degradation device and monitoring system for degradable biological material according to claim 1 or 2, wherein,
the upper part of the base plate (27) is connected with an infrared heating ring which is surrounded outside the experimental tube body (5) and is provided with a distance from the outer wall of the experimental tube body (5);
further comprises: a temperature sensor inserted into the experimental tube body (5);
the infrared heating ring and the temperature sensor are respectively connected with a test host, and the test host controls the operation of the infrared heating ring and acquires the internal temperature information of the test tube body (5) through the temperature sensor.
6. The dynamic degradation device and monitoring system for degradable biological material according to claim 1 or 2, wherein,
the camera module includes: a camera base (10), a telescopic rod (9) and a camera (8);
the imaging base (10) is provided with a rotating motor (31), and an output shaft of the rotating motor (31) is connected with a driving gear (32);
the bottom of the telescopic rod (9) is provided with a linkage gear (33), the linkage gear (33) is connected with a base rod, a rack is arranged in the base rod, and a push rod is connected in the base rod through the rack; the push rod is connected with a push rod motor; the top end of the push rod is connected with a camera (8);
the linkage gear (33) is meshed with the driving gear (32), the rotating motor (31) drives the driving gear (32) to rotate, the linkage gear (33) is driven to rotate, and the horizontal angle of the camera (8) is adjusted;
The push rod motor drives the push rod to move up and down along the rack inside the base rod, and the height of the camera (8) is adjusted.
7. The dynamic degradation device and monitoring system for degradable biological material according to claim 6, wherein,
the test host is also used for presetting the central line coordinate of the test tube body (5), and presetting a rectangular area which is formed by configuring the degradable biological material hydrogen evolution test image with uniform extension along the central line of the test tube body to two sides; configuring preset layering heights of layering each substance in the experimental tube body before or after reaction according to experimental requirements, and presetting layering images based on each layering height;
acquiring video information shot by a camera (8), separating the video information into degradable biological material hydrogen evolution experimental image data of each frame of image, and judging whether the central line coordinate of an experimental tube body (5) in the degradable biological material hydrogen evolution experimental image data is matched with the central line coordinate of the experimental tube body (5) in a preset degradable biological material hydrogen evolution experimental image when the degradable biological material hydrogen evolution experimental image data is displayed; if the two images are matched, acquiring data of a hydrogen evolution experiment image of the degradable biological material, searching a layered image in the test process based on pixel difference of the data of the hydrogen evolution experiment image of the degradable biological material, searching the boundary of the hydrogen evolution experiment image of the degradable biological material, dividing the layered image, comparing the layered image with a preset layered image to judge whether the sizes are the same, if the sizes are the same, configuring the current layered image as an image analysis area of the experiment process, and acquiring images of color change, sediment change and liquid level height change of substances in an experiment tube body in the experiment process;
The test server (3) is also used for sending a screenshot instruction for shooting a video image in the test process to the test host according to a control instruction of a tester or according to a preset time point or according to the setting of a test process stage point; and receiving a screenshot sent by the test host, and grabbing a test substance state image in the layered image for storage and display.
8. The dynamic degradation device and monitoring system for degradable biological material according to claim 1 or 2, wherein,
further comprises: a cleaning machine for cleaning the experimental equipment; the cleaning machine is provided with a shell (51), and the shell (51) is made of heat insulation materials; a door body (52) is hinged on the shell (51), the door body (52) is connected with the shell (51) in a sealing way, and a safety lock is arranged between the door body (52) and the shell (51);
the bottom of the shell (51) is connected with a support (59), a cleaning table (60) is arranged in the shell (51), and a heating device (54) and a lower water spraying hole (55) are arranged at the bottom of the cleaning table (60); the top of the cleaning table (60) is provided with an upper water spraying device (53); a floating control valve is also arranged on the cleaning table (60); a drain pipe (56) is further arranged at the bottom of the shell (51), and the drain pipe (56) is connected with a draining tank; the draining tank is arranged at the lower part of the table top;
the surface of the shell (51) is provided with a cleaning control button and a cleaning agent adding hole (57).
9. The dynamic degradation device and monitoring system for degradable biological material according to claim 1 or 2, wherein,
the coupling assembly includes: a sensor base (35), a sensor telescopic rod (9) and a crank rod (36);
the sensor base (35) is provided with a sensor rotating motor, and an output shaft of the sensor rotating motor is connected with a sensor driving gear; the bottom of the sensor telescopic rod (9) is provided with a sensor linkage gear, the sensor linkage gear is connected with a sensor base rod, a rack is arranged in the sensor base rod, and the sensor base rod is connected with a sensor push rod through the rack; the sensor push rod is connected with a sensor push rod motor; the top end of the sensor push rod is hinged with one end of a crank rod (36); the other end of the crank rod (36) is connected with a gas sensor (21);
the sensor linkage gear is meshed with the sensor driving gear, the sensor rotating motor drives the sensor driving gear to rotate, the sensor linkage gear is driven to rotate, and the horizontal angle of the gas sensor (21) is adjusted;
the sensor push rod motor drives the sensor push rod to move up and down along the rack inside the sensor base rod, and the height of the gas sensor (21) is adjusted.
10. The dynamic degradation device and monitoring system for degradable biological material according to claim 1 or 2, wherein,
The top of the experiment backboard (4) is provided with a top illuminating lamp, and one side of the experiment backboard (4) is provided with a side illuminating lamp (12); the top illuminating lamp and the side illuminating lamp (12) are respectively connected with the test host;
the test area is also provided with an ambient temperature sensor, an ambient humidity sensor and an ambient illuminance sensor;
the environment temperature sensor, the environment humidity sensor and the environment illuminance sensor are respectively connected with the test host, the test host sequentially acquires the environment temperature information, the environment humidity information and the environment illuminance information through the environment temperature sensor, the environment humidity information and the environment illuminance sensor, and when the environment temperature information, the environment humidity information and any information of the environment illuminance information are not matched with preset environment condition information required by the current test, the test host controls the environment temperature through controlling an air conditioner of a laboratory, controls the environment humidity through a humidifier and a dehumidifier of the laboratory, and controls illuminance of a test area through respectively controlling a switch of a top lighting lamp and a side lighting lamp (12).
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