CN109394813A - The medicinal extract preparation method extracted based on climbing groundsel effective component - Google Patents
The medicinal extract preparation method extracted based on climbing groundsel effective component Download PDFInfo
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Abstract
A kind of medicinal extract preparation method extracted based on climbing groundsel effective component, by by it is selected to the intact climbing groundsel medicinal material sequence of rhizome clean, profit bubble, after cutting operation, climbing groundsel medicinal material raw material to be boiled after obtaining dissection, again to climbing groundsel medicinal material after boiling raw material and carrying out decocting operation twice, first climbing groundsel is decocted into extracting solution and the second climbing groundsel decocts extracting solution and mixes, obtain climbing groundsel medicinal material solution to be concentrated, then it is pumped into medicinal material concentration kettle, successively carry out concentration operation twice, and collect and take away be discharged at the top of medicinal material concentration kettle steam vapour, obtain climbing groundsel medicinal material concentrate, climbing groundsel medicinal material liquid to be evaporated is obtained after filtering, it is finally laid on and carries out being evaporated operation on pallet, obtain the medicinal extract extracted based on climbing groundsel effective component.In this way, by above-mentioned preparation method, so that the recovery rate of the effective component of climbing groundsel medicinal material is higher and to prepare the product quality for the medicinal extract that the technique of medicinal extract is simpler, obtains more stable.
Description
Technical field
The present invention relates to a kind of field of pharmaceutical preparations, more particularly to a kind of medicinal extract extracted based on climbing groundsel effective component
Preparation method.
Background technique
Climbing groundsel also known as nine inner bright, Herba Senecionis Scandentis, HERBA SENECIONIS SCANDENTIS, bright stroke of eye, sweet vernal grass Broomjutre Sida Herb, Kowloon light, nine ridge light.For
Catananche, be born under hillside, sparse woods, Lin Bian, roadside, in limes marginis thick grass.Originate in Henan, Shaanxi, Jiangsu, Zhejiang, wide
West, Sichuan.Its is cold in nature, bitter, has clearing heat and detoxicating, eliminating stagnation to stop pain.For acute conjunctivitis, acute laryngopharyngitis, acute almond
Adenositis, chordapsus, acute bacillary dysentery, inflammation of upper respiratory tract, acute bronchitis, lymphnoditis, boil pain, tympanitis, dermatitis
Eczema.There is saying for " someone knowing to obtain climbing groundsel, and the whole family does not give birth to sore all one's life " civil, it is seen that it is with unique effects.
Climbing groundsel has broad-spectrum antibiotic effect, to staphylococcus aureus, typhoid bacillus, paratyphoid bacillus A, B-mode
Paratyphosum Bacterium, will he, Boydii, bacterium sonnei all have a strong inhibitory effect, at higher concentrations, to pathogenic large intestine
Bacillus and Pseudomonas aeruginosa also have inhibiting effect, also have different degrees of inhibiting effect to the bacillus such as deformation, waxy and sarcine.
In botany, pharmacology and toxicology, climbing groundsel is different from the other plants of Senecio, civil to be used to treat by climbing groundsel
A variety of diseases such as skin eczema, boil, typhoid fever, bacillary dysentery, lobar pneumonia, red eye, swell pain, desinsection, antipruritic.
Traditional climbing groundsel extracting method includes solvent extraction, separation by precipitation, steam distillation, molecular distillation technique
Deng.Although these methods are used in natural product extraction by most people, there is also many disadvantages, as universal in extraction process
Use a large amount of organic solvents；It is long to handle the time；Operating procedure is mostly etc..Thus sample loss is serious in experimentation, the mistake of generation
Difference is larger.
Summary of the invention
The purpose of the present invention is overcoming shortcoming in the prior art, a kind of climbing groundsel medicinal material effective component extraction is provided
The medicinal extract extracted based on climbing groundsel effective component that rate is higher, preparation process is simpler, product is more stable, quality is better
Preparation method.
The purpose of the present invention is achieved through the following technical solutions:
A kind of medicinal extract preparation method extracted based on climbing groundsel effective component, is included the following steps:
S110, under normal temperature environment, the intact climbing groundsel medicinal material of selected rhizome carries out climbing groundsel medicinal material sequence clear
It washes and moistens bubble operation, to soak the climbing groundsel medicinal material；
S120, the climbing groundsel medicinal material is put into medicinal material cutting machine progress cutting operation, rejects powder waste residue, is cut
Climbing groundsel medicinal material raw material to be boiled after section；
S130, climbing groundsel medicinal material raw material investment medicinal material to be boiled is decocted into kettle, and decocts kettle injection to the medicinal material and fits
Purified water is measured, then, first is carried out and decocts operation, obtain the first climbing groundsel and decoct extracting solution, and first climbing groundsel is decocted
Boil extracting solution be pumped into transition container it is spare；
S140, appropriate purified water is injected to completing described first and decoct the climbing groundsel medicinal material raw material to be boiled after operation again,
Then, it carries out second and decocts operation, obtain the second climbing groundsel and decoct extracting solution, and second climbing groundsel is decocted into extracting solution and is taken out
Enter spare into the transition container；
S150, the bottom that the climbing groundsel medicinal material raw material to be boiled after second decoction operates decocts kettle from the medicinal material will be completed
Portion is released, and it is spare to obtain the climbing groundsel medicinal material dregs of a decoction；
S160, in the transition container, first climbing groundsel is decocted into extracting solution and second climbing groundsel and is decocted
Extracting solution is mixed, and climbing groundsel medicinal material solution to be concentrated is obtained, and carries out the using gauze to the climbing groundsel medicinal material solution to be concentrated
One filter operation；
S170, the climbing groundsel medicinal material solution to be concentrated is pumped into the first medicinal material concentration kettle, under vacuum conditions, carries out the
One concentration operation, and the vapour that steams being discharged at the top of the first medicinal material concentration kettle is collected and takes away, it is dense to collect first medicinal material
The mother liquor in contracting bottom portion obtains the first climbing groundsel medicinal material concentrate, carries out the using gauze to the climbing groundsel medicinal material concentrate
Two filter operations；
S180, the first climbing groundsel medicinal material concentrate is pumped into the second medicinal material concentration kettle, under vacuum conditions, is carried out
Second concentration operation, and the vapour that steams being discharged at the top of the second medicinal material concentration kettle is collected and takes away, collect second medicinal material
The mother liquor of concentration kettle bottom obtains the second climbing groundsel medicinal material concentrate, uses gauze to the second climbing groundsel medicinal material concentrate
Third filter operation is carried out, climbing groundsel medicinal material liquid to be evaporated is obtained；
S190, the climbing groundsel medicinal material liquid to be evaporated is laid on pallet, and the pallet is fed through and is evaporated in case,
Under vacuum conditions, carry out being evaporated operation, and collect and take away it is described be evaporated box top discharge steam vapour so that a thousand li
The dehydration on the pallet of light medicinal material liquid to be evaporated obtains the medicinal extract extracted based on climbing groundsel effective component.
In one of the embodiments, in the step S110, to climbing groundsel medicinal material sequence carry out cleaning and
In profit bubble operating process, the time for carrying out profit bubble to the climbing groundsel medicinal material is 18 hours~24 hours.
In one of the embodiments, in the step S120, using vertical cut formula medicinal material cutting machine by the climbing groundsel
Medicinal material is cut into the section shape climbing groundsel medicinal material of 7cm~10cm length.
In one of the embodiments, in the step S130, climbing groundsel medicinal material raw material to be boiled is put into medicine
Material decocts kettle, and decocts kettle to the medicinal material and inject appropriate purified water, then, described during carrying out the first decoction operation
The volume ratio of climbing groundsel medicinal material raw material to be boiled and the purified water is 1:5.
The climbing groundsel medicinal material dregs of a decoction obtained in the step S150 are also subjected to high-temperature sterilization in one of the embodiments,
Operation, using 5 days~7 days fermentation operations, prepares fertilizer.
In one of the embodiments, in the step S160, yarn is being used to the climbing groundsel medicinal material solution to be concentrated
During net carries out the first filter operation, the gauze is 50 mesh~80 mesh cotton synthetic fibre gauze.
In one of the embodiments, in the step S170, institute is being carried out to the climbing groundsel medicinal material solution to be concentrated
During stating the first concentration operation, the agitating device in the first medicinal material concentration kettle is also to the climbing groundsel medicinal material solution to be concentrated
It is stirred the burnt operation in anti-part.
In one of the embodiments, in the step S180, also by the collection and to take second medicinal material away dense
The vapour that steams of contracting kettle top portion discharge is condensed, to be recycled.
In one of the embodiments, in the step S190, the climbing groundsel medicinal material liquid to be evaporated is laid on support
On disk, and the pallet is fed through and is evaporated in case, under conditions of 0.8MPa~0.85MPa, carries out being evaporated operation.
Medicinal extract in one of the embodiments, in the step S190, also to climbing groundsel effective component extraction
Dicing operation is carried out, medicinal extract block is obtained, the medicinal extract block is saved under normal temperature conditions.
The above-mentioned medicinal extract preparation method extracted based on climbing groundsel effective component, passes through a thousand li that the selected rhizome arrived is intact
After light medicinal material sequence is cleaned, moistens bubble, cutting operation, the climbing groundsel medicinal material raw material to be boiled after obtaining dissection, then to climbing groundsel
Medicinal material after boiling raw material and carrying out decocting operation twice, by the first climbing groundsel decoct extracting solution and the second climbing groundsel decoct extracting solution into
Row mixing, obtains climbing groundsel medicinal material solution to be concentrated, is then pumped into medicinal material concentration kettle, successively carry out concentration operation twice, and receive
Collect and take away be discharged at the top of medicinal material concentration kettle steam vapour, obtain climbing groundsel medicinal material concentrate, climbing groundsel medicinal material obtained after filtering
Liquid to be evaporated finally is laid on and carries out being evaporated operation on pallet, obtains the medicinal extract of climbing groundsel effective component extraction.In this way, passing through
Above-mentioned preparation method obtains so that the recovery rate of the effective component of climbing groundsel medicinal material is higher and to prepare the technique of medicinal extract simpler
The product quality of the medicinal extract arrived is more stable.
Detailed description of the invention
In order to illustrate the technical solution of the embodiments of the present invention more clearly, below will be to needed in the embodiment attached
Figure is briefly described, it should be understood that the following drawings illustrates only certain embodiments of the present invention, therefore is not construed as pair
The restriction of range for those of ordinary skill in the art without creative efforts, can also be according to this
A little attached drawings obtain other relevant attached drawings.
Fig. 1 is the step process of the medicinal extract preparation method extracted based on climbing groundsel effective component of one embodiment of the invention
Figure.
Specific embodiment
To facilitate the understanding of the present invention, a more comprehensive description of the invention is given in the following sections with reference to the relevant attached drawings.In attached drawing
Give better embodiment of the invention.But the invention can be realized in many different forms, however it is not limited to herein
Described embodiment.On the contrary, the purpose of providing these embodiments is that making to understand more the disclosure
Add thorough and comprehensive.
It should be noted that it can directly on the other element when element is referred to as " being fixed on " another element
Or there may also be elements placed in the middle.When an element is considered as " connection " another element, it, which can be, is directly connected to
To another element or it may be simultaneously present centering elements.Term as used herein " vertical ", " horizontal ", " left side ",
" right side " and similar statement for illustrative purposes only, are not meant to be the only embodiment.
Unless otherwise defined, all technical and scientific terms used herein and belong to technical field of the invention
The normally understood meaning of technical staff is identical.Term as used herein in the specification of the present invention is intended merely to description tool
The purpose of the embodiment of body, it is not intended that in the limitation present invention.Term " and or " used herein includes one or more
Any and all combinations of relevant listed item.
In one embodiment, a kind of medicinal extract preparation method extracted based on climbing groundsel effective component is included the following steps:
S110, under normal temperature environment, the intact climbing groundsel medicinal material of selected rhizome carries out climbing groundsel medicinal material sequence clear
It washes and moistens bubble operation, to soak the climbing groundsel medicinal material.
It is selected by the way that under normal temperature conditions, the intact climbing groundsel medicinal material of rhizome is carried out, the part of inferior quality is rejected, with
Guarantee the quality for the medicinal extract being prepared.It is appreciated that climbing groundsel medicinal material herb can be used for medicinal purpose, the intact climbing groundsel of selected rhizome
Medicinal material can guarantee that the utilization rate of the effective component to climbing groundsel medicinal material improves as raw material on source, while also can
Enough so that the effective component for the medicinal extract being prepared is more, preparation cost is reduced.In addition, in growth and transportational process, thousand
In light medicinal material inevitably remain the impurity such as some dusts, can be by the dust on climbing groundsel medicinal material by cleaning operation
Equal impurity are washed away, and the quality for the medicinal extract being prepared is further ensured.After the completion of cleaning, using the profit of certain time
Bubble operation, the climbing groundsel medicinal material of dry, hard to soak the climbing groundsel medicinal material, can be softened, facilitate subsequent cut
Cut operation.
It is cleaned and is moistened in bubble operating process to the climbing groundsel medicinal material sequence in one of the embodiments, it is right
The time that the climbing groundsel medicinal material carries out profit bubble is 18 hours~24 hours.It is steeped by 18 hours~24 hours profits, described thousand
In light medicinal material can fully absorb moisture, the softness that rhizome part is become by original hard state is cut into conducive to subsequent
Segment part and other steps.
S120, the climbing groundsel medicinal material is put into medicinal material cutting machine progress cutting operation, rejects powder waste residue, is cut
Climbing groundsel medicinal material raw material to be boiled after section.
Cutting operation is carried out by putting into the climbing groundsel medicinal material to medicinal material cutting machine, it can be by the climbing groundsel medicinal material
Dissection is carried out, the shorter climbing groundsel medicinal material of formation length facilitates subsequent put into medicinal material decoction kettle to carry out the operation such as decocting, together
When, the climbing groundsel medicinal material of segment also can carry out bigger contact area with decoction liquor, be conducive to having in climbing groundsel medicinal material
Effect ingredient carries out more thorough extract.It should be noted that some powders or powder waste residue can be generated after dissection, in order to
Guarantee the quality for the medicinal extract being prepared, while avoiding these powder waste residues from blocking medicinal material decoction kettle and causing failure
Deng also the powder waste residue generated in cutting operation process being rejected, to obtain the climbing groundsel medicinal material raw material to be boiled after dissection.
In one of the embodiments, using vertical cut formula medicinal material cutting machine by the climbing groundsel medicinal material be cut into 7cm~
The section shape climbing groundsel medicinal material of 10cm length.It, can be efficient by putting into the climbing groundsel medicinal material to vertical cut formula medicinal material cutting machine
The climbing groundsel medicinal material is carried out dissection by ground, while can adjust required size, is substantially increased effective based on climbing groundsel
The preparation efficiency of the medicinal extract of constituents extraction and the quality of product and stability.
S130, climbing groundsel medicinal material raw material investment medicinal material to be boiled is decocted into kettle, and decocts kettle injection to the medicinal material and fits
Purified water is measured, then, first is carried out and decocts operation, obtain the first climbing groundsel and decoct extracting solution, and first climbing groundsel is decocted
Boil extracting solution be pumped into transition container it is spare.
Kettle is decocted by the way that climbing groundsel medicinal material raw material to be boiled is put into medicinal material, and decocts kettle injection in right amount to the medicinal material
Purified water carries out first and decocts operation, the climbing groundsel medicinal material can be waited boiling effective component such as Hyperoside in raw material and
Alkaloid etc. extracts, and decocts extracting solution to obtain the first climbing groundsel, and first climbing groundsel is decocted extracting solution and is pumped into
It is spare into transition container.
Climbing groundsel medicinal material raw material to be boiled investment medicinal material is being decocted into kettle in one of the embodiments, and to described
Medicinal material decocts kettle and injects appropriate purified water, then, during carrying out the first decoction operation, the climbing groundsel medicinal material raw material to be boiled
Volume ratio with the purified water is 1:2.5.In this way, can be by the climbing groundsel medicinal material by the way that the more purified water is added
Raw material to be boiled sufficiently is submerged, and is sufficiently decocted conducive to the climbing groundsel medicinal material raw material to be boiled, by the climbing groundsel
The effective component of medicinal material raw material to be boiled extracts out.For another example, described in one of the embodiments, to carry out the first decoction behaviour
The time of work is 2 hours, in this way, can carry out climbing groundsel medicinal material raw material to be boiled abundant after high temperature decocts 2 hours
It decocts, the climbing groundsel medicinal material is waited boiling the effective component in raw material and is more fully extracted, be conducive to subsequent preparation
Obtain the better medicinal extract of quality.
S140, appropriate purified water is injected to completing described first and decoct the climbing groundsel medicinal material raw material to be boiled after operation again,
Then, it carries out second and decocts operation, obtain the second climbing groundsel and decoct extracting solution, and second climbing groundsel is decocted into extracting solution and is taken out
Enter spare into the transition container.
By re-injecting appropriate purified water to the climbing groundsel medicinal material raw material to be boiled after first decocts operation, the is carried out
Two decoct operation, further decoct the effective component that the climbing groundsel medicinal material after operation waits boiling in raw material for described first and extract
Out, the recovery rate and utilization rate of the climbing groundsel medicinal material are improved, decocts extracting solution to obtain the second climbing groundsel, and will be described
Second climbing groundsel decoction extracting solution is pumped into spare into the transition container.After preferably decocting operation for described first
The effective component that climbing groundsel medicinal material waits boiling in raw material extracts out, for example, described second decocts in operation, described first is decocted
The volume ratio of climbing groundsel medicinal material raw material to be boiled and the purified water after boiling operation is 1:1.5.So, it is possible further will be described
First effective component for decocting the climbing groundsel medicinal material raw material to be boiled after operation extracts out.For another example, an implementation wherein
In example, described to carry out the time that second decocts operation be 2 hours, in this way, after high temperature decocts 2 hours, it can be by described the
The one climbing groundsel medicinal material raw material to be boiled for decocting after operation is sufficiently decocted, and described first is decocted the climbing groundsel medicinal material after operation
It is more fully extracted wait boil the effective component in raw material, the better medicinal extract of quality is prepared conducive to subsequent.
S150, the bottom that the climbing groundsel medicinal material raw material to be boiled after second decoction operates decocts kettle from the medicinal material will be completed
Portion is released, and it is spare to obtain the climbing groundsel medicinal material dregs of a decoction.
After second climbing groundsel decoction extracting solution is taken away, described second will be completed and decoct the climbing groundsel medicinal material after operation
Raw material to be boiled is released from the bottom that the medicinal material decocts kettle, and it is spare to obtain the climbing groundsel medicinal material dregs of a decoction.
The climbing groundsel medicinal material dregs of a decoction obtained in the step S150 are also subjected to high-temperature sterilization in one of the embodiments,
Operation, using 5 days~7 days fermentation operations, prepares fertilizer.It is appreciated that the climbing groundsel medicinal material medicine after decocting operation
Slag also contains a large amount of Hubeiwans, such as crude fibre, crude protein, crude fat and various trace elements etc., can turn waste into wealth,
It recycling, this is just meeting the energy-saving and emission-reduction that the whole world is advocated, and low-carbon environment-friendly walks the theory of Green Sustainable road, for example,
After the dregs of a decoction being carried out high-temperature sterilization operation again, by 5 days~7 days fermentation operations, fertilizer is prepared, can be used for supporting
Flower, planting vegetable melon and fruit etc.；For another example, the nutritional ingredient that the climbing groundsel medicinal material dregs of a decoction contain a large amount of edibility bacterium growths can
To be used for culturing edible fungus, for another example, the formula of the culturing edible fungus is each component for including following mass parts: climbing groundsel medicinal material
45 parts~60 parts of the dregs of a decoction, 13 parts~16 parts of wheat bran, 2 parts~4 parts of land plaster, 1 part~2 parts of urea and 1 part~3 parts of calcium superphosphate,
In this way, more enough further recycle the climbing groundsel medicinal material dregs of a decoction, turns waste into wealth, meet Green Sustainable road
The theory on road.
S160, in the transition container, first climbing groundsel is decocted into extracting solution and second climbing groundsel and is decocted
Extracting solution is mixed, and climbing groundsel medicinal material solution to be concentrated is obtained, and carries out the using gauze to the climbing groundsel medicinal material solution to be concentrated
One filter operation.
By that will decoct twice, first climbing groundsel that operation obtains decocts extracting solution and second climbing groundsel decocts
Extracting solution is mixed, and climbing groundsel medicinal material solution to be concentrated can be obtained, it will be understood that in decoction process, the climbing groundsel medicine
The dregs of a decoction part that material waits boiling some clasts or segment in raw material can also remain in first climbing groundsel decoct extracting solution and
Second climbing groundsel decocts in extracting solution, therefore in order to avoid remaining the too many dregs of a decoction or miscellaneous in the climbing groundsel medicinal material solution to be concentrated
Matter, it is necessary to operation is filtered to the climbing groundsel medicinal material solution to be concentrated, for example, waiting for using gauze the climbing groundsel medicinal material
Concentrate carries out the first filter operation, can be removed dregs of a decoction part remaining in the climbing groundsel medicinal material solution to be concentrated,
The better medicinal extract of quality is prepared conducive to subsequent.
The first filter operation is being carried out using gauze to the climbing groundsel medicinal material solution to be concentrated in one of the embodiments,
In the process, the gauze is 50 mesh~70 mesh cotton synthetic fibre gauze.In this way, by using 50 mesh~70 mesh cotton synthetic fibre gauze to described
Climbing groundsel medicinal material solution to be concentrated carries out the first filter operation, can be by impurity such as the dregs of a decoction in the climbing groundsel medicinal material solution to be concentrated
It is filtered removing, it is less to be more advantageous to the subsequent impurity that is prepared, the better medicinal extract of quality.
S170, the climbing groundsel medicinal material solution to be concentrated is pumped into the first medicinal material concentration kettle, under vacuum conditions, carries out the
One concentration operation, and the vapour that steams being discharged at the top of the first medicinal material concentration kettle is collected and takes away, it is dense to collect first medicinal material
The mother liquor in contracting bottom portion obtains the first climbing groundsel medicinal material concentrate, carries out the using gauze to the climbing groundsel medicinal material concentrate
Two filter operations.
By the way that the climbing groundsel medicinal material solution to be concentrated after the first filter operation is pumped into the first medicinal material concentration kettle,
Under vacuum conditions, the first concentration operation is carried out, the moisture in the climbing groundsel medicinal material solution to be concentrated can be evaporated, be made
The concentration of the climbing groundsel medicinal material solution to be concentrated is promoted, be prepared medicinal extract conducive to subsequent, meanwhile, by first medicine
The vapour that steams being discharged at the top of material concentration kettle is collected and takes away, additionally it is possible to further it is recycled by condensation, in addition,
The mother liquor of the first medicinal material concentration kettle bottom after the first concentration operation is collected, the first climbing groundsel can be obtained
Medicinal material concentrate, it will be understood that still unavoidably there is also the dregs of a decoction more tiny a bit etc. are miscellaneous in the first climbing groundsel medicinal material concentrate
Matter, in order to further increase the quality of the subsequent medicinal extract being prepared, for example, also using yarn to the climbing groundsel medicinal material concentrate
Net carries out the second filter operation, so, it is possible to further increase the medicinal extract that the subsequent climbing groundsel effective component being prepared is extracted
Quality.
The first concentration operation process is being carried out to the climbing groundsel medicinal material solution to be concentrated in one of the embodiments,
In, it is burnt that the agitating device in the first medicinal material concentration kettle is also stirred anti-part to the climbing groundsel medicinal material solution to be concentrated
Operation.
It is appreciated that carrying out first concentration operation to the climbing groundsel medicinal material solution to be concentrated by heating operation
In the process, the climbing groundsel medicinal material solution to be concentrated of the first medicinal material concentration kettle bottom is easy because the heat being subject to is higher,
And during continuous concentration, the stickiness meeting of the climbing groundsel medicinal material solution to be concentrated of the first medicinal material concentration kettle bottom
It continues to increase, can constantly generate climbing groundsel medicinal material concentrate paste, in this way, passing through the stirring in the first medicinal material concentration kettle
Device is stirred the burnt operation in anti-part to the climbing groundsel medicinal material solution to be concentrated, can be avoided because first medicinal material is concentrated
The medicinal extract that part in kettle causes the climbing groundsel medicinal material solution to be concentrated to generate because of uneven heating is burnt by part.Further
Ground, time of first concentration operation are 45min~60min, the 10min started in first concentration operation~
15min, the mixing speed of the agitating device in the first medicinal material concentration kettle are 50r/min~80r/min, 16min~
30min, the mixing speed of the agitating device in the first medicinal material concentration kettle are 30r/min~60r/min, 16min~
30min, the mixing speed of the agitating device in the first medicinal material concentration kettle are 30r/min~60r/min, 31min~
The mixing speed of 60min, the agitating device in the first medicinal material concentration kettle are 20r/min~40r/min, in this way, with institute
The progress of the first concentration operation is stated, the solid content of the climbing groundsel medicinal material solution to be concentrated constantly increases, and stickiness is also constantly increasing
Greatly, the mixing speed for gradually reducing the agitating device in the first medicinal material concentration kettle can promote the climbing groundsel medicinal material to wait for
Concentrate is precipitated, and conducive to medicinal extract is subsequently formed, and it is burnt to can be avoided the climbing groundsel medicinal material solution to be concentrated part.
S180, the first climbing groundsel medicinal material concentrate is pumped into the second medicinal material concentration kettle, under vacuum conditions, is carried out
Second concentration operation, and the vapour that steams being discharged at the top of the second medicinal material concentration kettle is collected and takes away, collect second medicinal material
The mother liquor of concentration kettle bottom obtains the second climbing groundsel medicinal material concentrate, uses gauze to the second climbing groundsel medicinal material concentrate
Third filter operation is carried out, climbing groundsel medicinal material liquid to be evaporated is obtained.
By the way that the first climbing groundsel medicinal material concentrate to be pumped into the second medicinal material concentration kettle, under vacuum conditions, carry out
Second concentration operation, the more enough moisture further removed in the first climbing groundsel medicinal material concentrate improve first a thousand li
Concentration in light medicinal material concentrate, meanwhile, the vapour that steams being discharged at the top of the second medicinal material concentration kettle is collected and is taken away,
It can also further recycle, greatly reduce preparation cost, while also can be avoided the first climbing groundsel medicinal material concentration
The loss of effective component in liquid.After the completion of second concentration operation, the mother of the second medicinal material concentration kettle bottom is collected
Liquid can obtain the second climbing groundsel medicinal material concentrate, and carry out third using gauze to the second climbing groundsel medicinal material concentrate
Filter operation can further remove the paste or impurity of the second climbing groundsel medicinal material concentrate, can obtain a thousand li
Light medicinal material liquid to be evaporated.It should be noted that under vacuum conditions, the second concentration operation is carried out, it can be in the item of lower temperature
Under part, reach the boiling point of the first climbing groundsel medicinal material concentrate, reduces consumption and the preparation cost of the energy, meanwhile, also more
Be conducive to that the vapour that steams being discharged at the top of the second medicinal material concentration kettle is collected and is taken away, prepare medicinal extract to greatly improve
Efficiency, be more suitable large-scale industrial production.
In one of the embodiments, also steaming for the second medicinal material concentration kettle top discharge is collected and taken away by described
Vapour is condensed, to be recycled.
It is appreciated that during carrying out the second concentration operation, the moisture meeting of the first climbing groundsel medicinal material concentrate
Constantly evaporation, while it is also possible to carry the effective component of part climbing groundsel medicinal material, by the collection and taking described the away
The vapour that steams being discharged at the top of two medicinal material concentration kettles is condensed, and is able to carry out and is recycled, and is reduced Energy Consumption Cost, is also improved
The recovery rate of climbing groundsel medicinal material effective component.
It should be strongly noted that in order to improve the quality for the medicinal extract being prepared, for example, to the second climbing groundsel medicine
After material concentrate carries out third filter operation using gauze, also progress alcohol precipitation operation specifically comprises the following steps: S181, to institute
The ethyl alcohol for being added that mass concentration is 95% in the second climbing groundsel medicinal material concentrate is stated, ultrasonic oscillation operation is carried out；S182, control
When the alcohol content of the second climbing groundsel medicinal material concentrate reaches 50%, stop that ethyl alcohol is added, and stand 12 hours~24 hours；
S183, the second climbing groundsel medicinal material concentrate is filtered operation, obtains alcohol-containing medical fluid, filter residue is spare；S184, to described
Alcohol-containing medical fluid carries out third concentration operation, and collects and recycle ethyl alcohol, obtains the climbing groundsel medicinal material liquid to be evaporated.In this way, logical
It crosses and purifying purification operations is carried out to the second climbing groundsel medicinal material concentrate, it can will be in the second climbing groundsel medicinal material concentrate
Many water-solubility impurities be removed so that the purity of the subsequent obtained climbing groundsel medicinal material liquid to be evaporated is higher, be conducive to
The subsequent medicinal extract that quality is prepared and is preferably extracted based on climbing groundsel effective component.
S190, the climbing groundsel medicinal material liquid to be evaporated is laid on pallet, and the pallet is fed through and is evaporated in case,
Under vacuum conditions, carry out being evaporated operation, and collect and take away it is described be evaporated box top discharge steam vapour so that a thousand li
The dehydration on the pallet of light medicinal material liquid to be evaporated obtains the medicinal extract extracted based on climbing groundsel effective component.
By the way that the climbing groundsel medicinal material liquid to be evaporated to be laid on pallet, and the pallet is fed through and is evaporated in case,
Under vacuum conditions, it carries out being evaporated operation, enables to climbing groundsel medicinal material liquid to be evaporated dehydration on the pallet, obtain
The medicinal extract extracted based on climbing groundsel effective component.Meanwhile in being evaporated operating process, steaming for box top discharge is evaporated by described
Vapour is collected and takes away, can further pass through condensation operation, be recycled, improve having for the climbing groundsel medicinal material
Imitate the utilization rate of ingredient.
The climbing groundsel medicinal material liquid to be evaporated is laid on pallet in one of the embodiments, and by the pallet
It is fed through and is evaporated in case, under conditions of 0.8MPa~0.85MPa, carry out being evaporated operation.By 0.8MPa~0.85MPa's
Under vacuum condition, can more quickly the climbing groundsel medicinal material liquid to be evaporated be heated and is evaporated, be steamed compared to normal pressure
It is dry, 9 hours are shortened, the energy is greatly saved and shortens drying time.Further, in order to guarantee the climbing groundsel medicine
The quality for steaming speed and the subsequent medicinal extract being prepared of material liquid to be evaporated, for example, the climbing groundsel medicinal material is waited being evaporated
Liquid be laid on pallet with a thickness of 1.5cm~3cm, more quickly the climbing groundsel medicinal material liquid to be evaporated can be steamed
Dry, the time is shorter due to being evaporated, and can guarantee that the climbing groundsel medicinal material waits being evaporated the climbing groundsel effective component in liquid and is not easy to be broken
It is bad；For another example, the temperature that operation is evaporated described in progress is 70 DEG C~90 DEG C, so, it is possible to avoid because temperature is excessively high, and is destroyed effective
Ingredient, for another example, the temperature for being evaporated operation be 80 DEG C, when the climbing groundsel medicinal material liquid to be evaporated steam to moisture be 5% with
From case taking-up is evaporated when lower, it so, it is possible to make climbing groundsel medicinal material liquid to be evaporated dehydration on the pallet, obtain based on thousand
In light effective component extract medicinal extract.
Dicing operation also is carried out to the medicinal extract extracted based on climbing groundsel effective component in one of the embodiments,
Medicinal extract block is obtained, the medicinal extract block is saved under normal temperature conditions.
After being evaporated operation, the medicinal extract extracted based on climbing groundsel effective component can be obtained, but due to relatively large leaching
Cream is unfavorable for transporting and save, for example, also carrying out dicing operation to the medicinal extract that the climbing groundsel effective component is extracted, obtains medicinal extract
Block saves the medicinal extract block under normal temperature conditions, in this way, being more advantageous to the leaching extracted to the climbing groundsel effective component
Cream carries out storage and transport.
Compared with prior art, the present invention has at least the following advantages:
The medicinal extract preparation method extracted based on climbing groundsel effective component provided through the invention, enables to climbing groundsel medicine
The recovery rate of the effective component of material is higher and to prepare the product quality for the medicinal extract that the technique of medicinal extract is simpler, obtains more steady
It is fixed.
The embodiments described above only express several embodiments of the present invention, and the description thereof is more specific and detailed, but simultaneously
It cannot therefore be construed as limiting the scope of the patent.It should be pointed out that coming for those of ordinary skill in the art
It says, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to protection of the invention
Range.Therefore, the scope of protection of the patent of the invention shall be subject to the appended claims.
Claims (10)
1. a kind of medicinal extract preparation method extracted based on climbing groundsel effective component, which comprises the steps of:
S110, under normal temperature environment, the intact climbing groundsel medicinal material of selected rhizome, to climbing groundsel medicinal material sequence carry out cleaning and
Profit bubble operation, to soak the climbing groundsel medicinal material；
S120, the climbing groundsel medicinal material is put into medicinal material cutting machine progress cutting operation, powder waste residue is rejected, after obtaining dissection
Climbing groundsel medicinal material raw material to be boiled；
S130, climbing groundsel medicinal material raw material investment medicinal material to be boiled is decocted to kettle, and appropriate pure to medicinal material decoction kettle injection
Change water, then, carry out first and decoct operation, obtains the first climbing groundsel and decoct extracting solution, and first climbing groundsel decoction is mentioned
Liquid is taken to be pumped into transition container spare；
S140, appropriate purified water is injected to completing described first and decoct the climbing groundsel medicinal material raw material to be boiled after operation again, then,
Carry out second decoct operation, obtain the second climbing groundsel decoct extracting solution, and by second climbing groundsel decoction extracting solution be pumped into
It is spare in the transition container；
S150, will complete it is described second decoct operation after climbing groundsel medicinal material raw material to be boiled from the medicinal material decoct kettle bottom let out
Out, it is spare that the climbing groundsel medicinal material dregs of a decoction are obtained；
S160, in the transition container, first climbing groundsel decocted into extracting solution and second climbing groundsel decoct and extract
Liquid is mixed, and climbing groundsel medicinal material solution to be concentrated is obtained, and carries out the first mistake using gauze to the climbing groundsel medicinal material solution to be concentrated
Filter operation；
S170, the climbing groundsel medicinal material solution to be concentrated is pumped into the first medicinal material concentration kettle, under vacuum conditions, it is dense carries out first
Contracting operation, and the vapour that steams being discharged at the top of the first medicinal material concentration kettle is collected and takes away, collect the first medicinal material concentration kettle
The mother liquor of bottom obtains the first climbing groundsel medicinal material concentrate, carries out the second mistake using gauze to the climbing groundsel medicinal material concentrate
Filter operation；
S180, the first climbing groundsel medicinal material concentrate is pumped into the second medicinal material concentration kettle, under vacuum conditions, carries out second
Concentration operation, and the vapour that steams being discharged at the top of the second medicinal material concentration kettle is collected and takes away, collect the second medicinal material concentration
The mother liquor in bottom portion obtains the second climbing groundsel medicinal material concentrate, is carried out to the second climbing groundsel medicinal material concentrate using gauze
Third filter operation obtains climbing groundsel medicinal material liquid to be evaporated；
S190, the climbing groundsel medicinal material liquid to be evaporated is laid on pallet, and the pallet is fed through and is evaporated in case, true
Under empty condition, be evaporated operation, and collect and take away it is described be evaporated box top discharge steam vapour so that the climbing groundsel medicine
The dehydration on the pallet of material liquid to be evaporated obtains the medicinal extract extracted based on climbing groundsel effective component.
2. the medicinal extract preparation method according to claim 1 extracted based on climbing groundsel effective component, which is characterized in that in institute
It states in step S110, is cleaned and moistened in bubble operating process to the climbing groundsel medicinal material sequence, to the climbing groundsel medicinal material
The time for carrying out profit bubble is 18 hours~24 hours.
3. the medicinal extract preparation method according to claim 1 extracted based on climbing groundsel effective component, which is characterized in that in institute
It states in step S120, the climbing groundsel medicinal material is cut into the section shape thousand of 7cm~10cm length using vertical cut formula medicinal material cutting machine
In light medicinal material.
4. the medicinal extract preparation method according to claim 1 extracted based on climbing groundsel effective component, which is characterized in that in institute
It states in step S130, climbing groundsel medicinal material raw material investment medicinal material to be boiled is being decocted into kettle, and decoct kettle injection to the medicinal material
Appropriate purified water, then, carry out first decoct operation during, the climbing groundsel medicinal material raw material to be boiled and the purified water
Volume ratio is 1:5.
5. the medicinal extract preparation method according to claim 1 extracted based on climbing groundsel effective component, which is characterized in that will also
The climbing groundsel medicinal material dregs of a decoction obtained in the step S150 carry out high-temperature sterilization operation, using 5 days~7 days fermentation operations,
Prepare fertilizer.
6. the medicinal extract preparation method according to claim 1 extracted based on climbing groundsel effective component, which is characterized in that in institute
It states in step S160, during carrying out the first filter operation using gauze to the climbing groundsel medicinal material solution to be concentrated, the yarn
Net is 50 mesh~80 mesh cotton synthetic fibre gauze.
7. the medicinal extract preparation method according to claim 1 extracted based on climbing groundsel effective component, which is characterized in that in institute
It states in step S170, during carrying out first concentration operation to the climbing groundsel medicinal material solution to be concentrated, first medicine
Agitating device in material concentration kettle is also stirred the burnt operation in anti-part to the climbing groundsel medicinal material solution to be concentrated.
8. the medicinal extract preparation method according to claim 1 extracted based on climbing groundsel effective component, which is characterized in that in institute
It states in step S180, also condenses the vapour that steams for collecting and taking away discharge at the top of the second medicinal material concentration kettle, with
It is recycled.
9. the medicinal extract preparation method according to claim 1 extracted based on climbing groundsel effective component, which is characterized in that in institute
It states in step S190, the climbing groundsel medicinal material liquid to be evaporated is laid on pallet, and the pallet is fed through and is evaporated in case,
Under conditions of 0.8MPa~0.85MPa, carry out being evaporated operation.
10. the medicinal extract preparation method according to claim 1 extracted based on climbing groundsel effective component, which is characterized in that
In the step S190, dicing operation also is carried out to the medicinal extract that the climbing groundsel effective component is extracted, medicinal extract block is obtained, to institute
Medicinal extract block is stated to save under normal temperature conditions.
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