CN109394794A - The composite probiotics preparations and preparation method of prophylactic treatment gynecological disease and application - Google Patents
The composite probiotics preparations and preparation method of prophylactic treatment gynecological disease and application Download PDFInfo
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- A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
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Abstract
The present invention relates to a kind of composite probiotics preparations and preparation method thereof of prophylactic treatment gynecological disease, it is made of by mass percentage following components: Freeze-dry Powder of Probioctics 10 ~ 30%, prebiotics 20 ~ 50%, auxiliary material surplus, wherein, the Freeze-dry Powder of Probioctics is one of bifidobacterium longum, bifidobacterium animalis subspecies, Lactobacillus rhamnosus, lactobacillus plantarum, lactobacillus paracasei and Lactobacillus salivarius or a variety of, and preparation process is as follows: (1) weighing in proportion after being screened the raw material of composite probiotics preparations；(2) load weighted raw material is mixed；(3) raw material mixed progress tabletting is obtained into composite probiotics preparations.Preparation of the invention is combined using a variety of primary probiotics, and is accompanied by prebiotics and health care auxiliary material, makes the composite probiotics preparations diversification of preparation, it is multiple functional, nutritive value is high, effectively prophylactic treatment gynecological disease, and healing for puerpera's postoperative wound and preventing infection also has positive effect.
Description
Technical field
The present invention relates to field compound probiotic technical fields, more particularly to a kind of the compound of prophylactic treatment gynecological disease
Probiotics preparation and preparation method and application.
Background technique
Scientific research discovery, people is not present in nature with monolithic entity, on the contrary, people is that people itself and human body are micro-
One homobium (Holobionts) of biological flora composition, microbial flora include beneficial bacterium, commensal bacteria (unhelpful harmless), have
Evil bacterium and pathogenic bacteria etc..In this homobium, artificial microorganism provides living environment and nutrition, and microorganism participant is almost
All growth and development processes, including it is sick, dead.Human flora in baby due, after having eaten first milk about two hours i.e. by
It gradually sets up, accompanies people's all one's life always.Human flora is mainly distributed on the positions such as oral cavity, enteron aisle, genitals and body surface, plants number
More than 1000 kinds, individual amount reaches 1014, this quantity is about 10 times of human body cell sum, therefore, someone says that flora is people
The maximum organ of body, this has scientific basis.Beneficial bacterium or commensal bacteria are dominant in healthy human body, and harmful bacteria does not have with pathogenic
Have or seldom (such case is carried disease germs for recessiveness, without symptom), for beneficial bacterium for maintaining health, strengthen immunity prevents disease
Play indispensable role.
However, due to congenital heredity factor or people's extra-uterine life study and work environment, Diet lifestyle, sick
The reasons such as medication, human flora can also lack of proper care, i.e., total flora abundance reduces (type reduction)；Alternatively, harmful bacteria and pathogenic bacteria
Increase, and beneficial bacterium is reduced.A large number of studies show that many gynecological diseases and vaginal flora or even intestinal bacilli illness are related.Yin
Road flora imbalance is usually expressed as kinds of lactobacillus or quantity is reduced, and harmful bacteria, pathogenic bacteria type or quantity increase.Female reproduction
System is by big nymphae, clitoris, vagina, posterior fornix, cervix, endometrium, fallopian tubal, ovary and surrounding tissue group
At according to statistics, up to 84% women can obtain genital system diseases more than once in life.The World Health Organization (WHO) is by reproduction
Infection is classified as level Four, and genital infection the result is that often genital system diseases, and it is possible to by genital system diseases
And then developing is other organ diseases or even systemic disease.
Level-one genital infection: AIDS (HIV).
Second level genital infection: syphilis (microspironema pallidum Treponema Pallidum), stranguria syndrome (stranguria syndrome neisseria gonorrhoeae
Neisseria gonorrhoeae), chancroid (haemophilus ducreyi Hemophilus ducreyi), genital infection leaching
Bar granuloma (Chlamydia Chlamydia), granuloma inguinale (Calymmatobacterium granulomatis calymmatobacterium
Granulomatis), non-gonococcal urethritis (mycoplasma Mycoplasma, Chlamydia Chlamydia), genital infection clothing are former
Body disease, Urogenital Mycoplasma disease, trichomonas vaginitis (Trichomonas vaginalis), bacterial vaginitis, reproduction
Infective vaginitis, genital infection pelvic inflammatory disease (various bacteria, such as Escherichia coli Escherichia coli, Fei Shi citric acid
Bacillus Citrobter freumdii, staphylococcus Staphylococcus, proteus Proteus species), lung
Scorching diplococcus Diplococcus pneumoniae etc. and fungi).
Three-level genital infection: condyloma acuminatum (human papilloma virus HPV), genital herpes (herpes simplex virus HSV), yin
Portion's candidiasis (Candida albicans Monilia albican), molluscum contagiosum (CMV), Gartner bacterium vaginitis
(Gardnerella vaginalis), genital infection perihepatitis, B crowds of assistant coccus disease (Streptococcusagalactiae Streptococcus
Agalactiae), hepatitis B (HBV), scabies (itch mite Sarcoptes scabiei), pediculosis pubis (Pediculosis
Pubis), human cytomegalovirus is sick (human cytomegalovirus).
Level Four genital infection: giardiasis (Giardia lamblia), campylobacteriasis (Campylo-
Bacter sp.), amcbiasis (Entamoeba sp.), salmonellosis (Salmonella spp.), shigellosis
(Shigella Castellani), hepatitis A (HAV).
Genital system diseases commonly various inflammation (vulvitis, vaginitis, cervicitis, salpingitis, pelvic inflammatory disease), no
It is showed only as the symptoms such as redness, pruritus vulvae, pain, peculiar smell, leukorrhea, premature menopause, it is also possible to develop into pernicious swollen
Tumor influences physically and mentally healthy and love life.In addition, these communicable diseases are also possible to lead to infertile, premature labor, stillborn foetus, with
And disease is transmitted to the next generation, is transmitted to spouse, cause the pain of more people.A large amount of clinical tests prove, raw by reasonable diet
Conditioning living, or take in time, external application probiotics preparation product, to increase reproductive system probiotics quantity, for preventing or
Treatment gynecological disease has remarkable efficacy.The mechanism of probiotics prophylactic treatment gynaecological disease mainly has the following:
1, antagonism.Probiotics generates restraining and sterilizing bacteria substance, including a variety of short chain fatty acids such as lactic acid, acetic acid, butyric acid, third
Acid, H2O2, bacteriocin, antibacterial peptide etc., these inhibition strong to pathogenic bacteria, harmful bacteria or kill function, protect vaginal flora not by
Infringement, it is not infected.The acids of lactic acid bacteria secretion makes vagina keep normal acidic environment (pH≤4.5, mostly in 3.8-4.4),
It is suppressed the pathogen for being adapted to breed in neutral and weakly alkaline environment, this is the important of women own nature defense function
Part.
2, promote Development of Reproductive System.The normal growth and development or normal function of female reproductive system play all with vagina just
Normal micropopulation has close relationship.In the case where flora imbalance, entire reproductive system can all have organic and functional
Variation, and sufficient beneficial bacterium is exactly garrison or the check man of vagina, is escort for reproduction system health.
3, vagina mucosa is activated.Vagina mucosa health status and normal secreting function are kept, this is necessary to sexual behaviour,
It is also necessary to antibacterial diseases prevention, probiotics has activation mucous membrane, has repair even for damage mucous membrane.
4, nourishing effect is purified.Vaginal flora plays the role of decomposing Toxic, putrefaction and old waste, and abnormal secretion is such as
Leukorrhea, menstruation residue, lochia and fish raw meat are hidden etc. and harmful bacteria, pathogenic bacteria generate poisonous and harmful substance all can be by normal yin
Beneficial substance is removed or manufactured to road flora decomposition.
5, strengthen immunity.Human immune system is in addition to lymphatic system, oral cavity, enteron aisle, skin etc., there are also vagina, and it is negative
Road profitable strain has immunoregulation effect, has positive effect to maintenance and enhancing vagina immunity.
According to the definition of FAO (Food and Agriculture Organization of the United Nation) (FAO) and the World Health Organization (WHO), probiotics is microorganism living,
When taking in liberal quantity, one or more functional health benefits by demonstration are generated to host.Probiotics is usually fixed
It plants in human oral cavity, enteron aisle, reproductive system, main species have: lactobacillus, Bifidobacterium, bacillus, Miyarisan, unwrapping wire
Bacterium, saccharomycete etc..With the development of science and technology, integrating science and technology, fashion, health, the probiotic food of nutrition, health care product, drink
Material, drug, amenities etc. are increasingly by the welcome of consumer.
Existing probiotics preparation is commonly used to food and drug, seldom specifically for the product of externally-applied female.Even and if
Some Ms's articles, there is also strains entirely from external import, and strain is single, has a single function, poor for applicability, prevents and cures diseases
The problems such as effect is poor.It is both domestic and external a large amount of scientific investigations showed that, the probiotics from this foundation of a nation group is most suitable for this group human body,
That is Chinese primary probiotics is most suitable for Chinese.Strain used in the present invention all is from the Healthy People in the township of Chinese longevity
Body registers preservation in China national strain library.
Summary of the invention
To achieve the above object, the present invention adopts the following technical scheme:
A kind of composite probiotics preparations of prophylactic treatment gynecological disease, are made of by mass percentage following components: probiotics is frozen
Dry powder 10 ~ 30%, prebiotics 20 ~ 50%, auxiliary material surplus, wherein the Freeze-dry Powder of Probioctics is bifidobacterium longum
(Bifidobacterium longum), bifidobacterium animalis subspecies (Bifidobacteria animalis
Subsp.lactis), Lactobacillus rhamnosus (Lactobacillus rhamnosus), lactobacillus plantarum (Lactobacillus
Plantarum), lactobacillus paracasei (Lactobacillus paracasei) and Lactobacillus salivarius (Lactobacillus
Salivarius one of) or a variety of, the prebiotics are oligofructose, inulin, xylo-oligosaccharide, galactooligosaccharide, oligomeric
One of maltose, oligoisomaltose, soyabean oligosaccharides, stachyose, chitosan, gossypose are a variety of.
Lactobacillus plantarum (Lactobacillus plantarum), deposit number: CGMCC NO.15029, preservation date:
On December 7th, 2017；Bifidobacterium longum (Bifidobacterium longum), deposit number: CGMCC NO.15028, preservation
Date: on December 7th, 2017；Lactobacillus rhamnosus (Lactobacillus rhamnosus), deposit number: CGMCC
NO.15027, preservation date: on December 7th, 2017；Bifidobacterium animalis subspecies (Bifidobacteria animalis
Subsp.lactis), deposit number: CGMCC NO.15026, preservation date: on December 7th, 2017；Lactobacillus paracasei
(Lactobacillus paracasei), deposit number: CGMCC NO.15025, preservation date: on December 1st, 2017；Saliva
Lactobacillus (Lactobacillus salivarius), deposit number: CGMCC NO.15701, preservation date: April 28 in 2018
Day.Above-mentioned six strains are in China Committee for Culture Collection of Microorganisms's common micro-organisms center (CGMCC) preservation (
Location: Yard 1, BeiChen xi Road, Chaoyang District, Beijing City 3, Institute of Microorganism, Academia Sinica).
Preferably, viable count >=1 × 10 of the Freeze-dry Powder of Probioctics10/ gram.
Preferably, the auxiliary material water, sodium chloride, lactose, astaxanthin, converted starch, wave uric acid, gum arabic, sweet
Oil, gelatin, vegetable oil, glyceride, citric acid, sodium bicarbonate, selenium, two or more mixture in magnesium stearate.
Preferably, the form of the composite probiotics preparations of the prophylactic treatment gynecological disease be pulvis, tablet, capsule,
Suppository, gelling agent, paste, creme, spray, Disket, effervescent tablet, washing lotion, or with condom, sanitary napkin, health
The form that protection pad combines.
Wherein, inorganic selenium sodium selenite can be selected in selenium powder, and dosage is atomic, 100-300 microgram/KG product；Selenium powder can also
It is organic selenium or active selenium.
A kind of preparation method of the composite probiotics preparations of prophylactic treatment gynecological disease, it is characterised in that: including following step
It is rapid:
(1) it is weighed in proportion after being screened the raw material of the composite probiotics preparations of prophylactic treatment gynecological disease；
(2) load weighted raw material is mixed；
(3) raw material mixed is carried out moulding molding, the as composite probiotics preparations of prophylactic treatment gynecological disease.
A kind of application of the composite probiotics preparations of prophylactic treatment gynecological disease, comprising the following steps: by compound probiotic
Preparation is added in sanitary napkin or panty liner.
The invention has the benefit that the preparation method of the composite probiotics preparations of prophylactic treatment gynecological disease of the invention
It is combined using a variety of probiotics, and is accompanied by prebiotics cooperation, make the composite probiotics preparations diversification of preparation, multiple functional, battalion
It is high to support value, it can effectively prophylactic treatment gynecological disease.
Specific embodiment
A specific embodiment of the invention is described in detail with reference to embodiments.
Embodiment 1
The method for preparing the composite probiotics preparations of 100g prophylactic treatment gynecological disease, comprising the following steps:
(1) raw material is screened, and is weighed in the following proportions: Freeze-dry Powder of Probioctics 30g, prebiotics 40g, auxiliary material 30g,
Wherein, the Freeze-dry Powder of Probioctics is lactobacillus paracasei (Lactobacillus paracasei), the Freeze-dry Powder of Probioctics
Viable count >=1X 1010/ gram, the prebiotics are inulin, oligofructose, xylo-oligosaccharide and stachyose etc., and the auxiliary material is chlorine
Change sodium, lactose, astaxanthin.
(2) load weighted raw material is mixed；
(3) raw material mixed progress tabletting is obtained to the composite probiotics preparations of 100g prophylactic treatment gynecological disease.
Embodiment 2
The method for preparing the composite probiotics preparations of 100g prophylactic treatment gynecological disease, comprising the following steps:
(1) raw material is screened, and is weighed in the following proportions: Freeze-dry Powder of Probioctics 30g, prebiotics 40g, auxiliary material 30g,
Wherein, the Freeze-dry Powder of Probioctics is bifidobacterium animalis subspecies (Bifidobacteria animalis
Subsp.lactis) and the mixture of Lactobacillus rhamnosus (Lactobacillus rhamnosus), the two arbitrary proportion are mixed
It closes, viable count >=1X 10 of the Freeze-dry Powder of Probioctics10/ gram, the prebiotics are inulin, oligofructose, xylo-oligosaccharide and low
The mixture of poly- galactolipin, they are mixed in any proportion, and the auxiliary material is sodium chloride, lactose, astaxanthin, citric acid, selenium powder；
(2) load weighted raw material is mixed；
(3) raw material mixed progress tabletting is obtained to the composite probiotics preparations of 100g prophylactic treatment gynecological disease.
Embodiment 3
The method for preparing the composite probiotics preparations of 100g prophylactic treatment gynecological disease, comprising the following steps:
(1) raw material is screened, and is weighed in the following proportions: Freeze-dry Powder of Probioctics 30g, prebiotics 40g, auxiliary material 30g,
Wherein, the Freeze-dry Powder of Probioctics is lactobacillus plantarum (Lactobacillus plantarum), lactobacillus paracasei
The mixture of (Lactobacillus paracasei) and Lactobacillus salivarius (Lactobacillus salivarius), three
Arbitrary proportion mixing, viable count >=1X 10 of the Freeze-dry Powder of Probioctics10/ gram, the prebiotics are inulin, oligofructose, low
The mixture of xylan and oligoisomaltose, they are mixed in any proportion, the auxiliary material be sodium chloride, lactose, astaxanthin,
Wave uric acid, gum arabic, glycerol, gelatin, selenium powder；
(2) load weighted raw material is mixed；
(3) raw material mixed progress tabletting is obtained to the composite probiotics preparations of 100g prophylactic treatment gynecological disease.
Embodiment 4
The method for preparing the composite probiotics preparations of 100g prophylactic treatment gynecological disease, comprising the following steps:
(1) raw material is screened, and is weighed in the following proportions: Freeze-dry Powder of Probioctics 30g, prebiotics 40g, auxiliary material 30g,
Wherein, the Freeze-dry Powder of Probioctics is bifidobacterium longum (Bifidobacterium longum), bifidobacterium animalis subspecies
(Bifidobacteria animalis subsp.lactis), Lactobacillus rhamnosus (Lactobacillus rhamnosus)
With the mixture of lactobacillus plantarum (Lactobacillus plantarum), the mixing of four arbitrary proportions, the probiotics freeze-drying
Viable count >=1X 10 of powder10/ gram, the prebiotics are oligomeric lollipop, soyabean oligosaccharides, stachyose, chitosan and gossypose
Mixture, they are mixed in any proportion, the auxiliary material be sodium chloride, lactose, astaxanthin, citric acid, sodium bicarbonate；
(2) load weighted raw material is mixed；
(3) raw material mixed progress tabletting is obtained to the composite probiotics preparations of 100g prophylactic treatment gynecological disease.
Embodiment 5
The method for preparing the composite probiotics preparations of 100g prophylactic treatment gynecological disease, comprising the following steps:
(1) raw material is screened, and is weighed in the following proportions: Freeze-dry Powder of Probioctics 30g, prebiotics 40g, auxiliary material 30g,
Wherein, the Freeze-dry Powder of Probioctics is bifidobacterium longum (Bifidobacterium longum), bifidobacterium animalis subspecies
(Bifidobacteria animalis subsp.lactis), Lactobacillus rhamnosus (Lactobacillus rhamnosus),
Lactobacillus plantarum (Lactobacillus plantarum), lactobacillus paracasei (Lactobacillus paracasei) and saliva
The mixture of liquid lactobacillus (Lactobacillus salivarius), a few person's arbitrary proportion mixing, the Freeze-dry Powder of Probioctics
Viable count >=1X 1010/ gram, the prebiotics be the prebiotics be xylo-oligosaccharide, galactooligosaccharide, oligoisomaltose,
Soyabean oligosaccharides, stachyose, chitosan and gossypose mixture, the mixing of a few person's arbitrary proportions, the auxiliary material is sodium chloride, cream
Sugar, astaxanthin, converted starch, gum arabic, glycerol, gelatin, trace elements of selenium；
(2) load weighted raw material is mixed；
(3) raw material mixed progress tabletting is obtained to the composite probiotics preparations of 100g prophylactic treatment gynecological disease.
Embodiment 6
The method for preparing the composite probiotics preparations of 50g prophylactic treatment gynecological disease, comprising the following steps:
(1) raw material is screened, and is weighed in the following proportions: Freeze-dry Powder of Probioctics 15g, prebiotics 20g, auxiliary material 15g,
Wherein, the Freeze-dry Powder of Probioctics is lactobacillus paracasei (Lactobacillus paracasei), the Freeze-dry Powder of Probioctics
Viable count >=1X 1010/ gram, the prebiotics are inulin, oligofructose, xylo-oligosaccharide and stachyose mixture, the auxiliary material
For gelatin, vegetable oil, glyceride, citric acid mixture.
(2) load weighted raw material is mixed；
(3) raw material mixed progress tabletting is obtained to the composite probiotics preparations of 50g prophylactic treatment gynecological disease.
Embodiment 7
The method for preparing the composite probiotics preparations of 100g prophylactic treatment gynecological disease, comprising the following steps:
(1) raw material is screened, and is weighed in the following proportions: Freeze-dry Powder of Probioctics 30g, prebiotics 40g, auxiliary material 30g,
Wherein, the Freeze-dry Powder of Probioctics is bifidobacterium animalis subspecies (Bifidobacteria animalis
Subsp.lactis), viable count >=1X 10 of the Freeze-dry Powder of Probioctics10/ gram, the prebiotics are oligoisomaltose, greatly
Beans oligosaccharide, stachyose, chitosan, gossypose mixture, the auxiliary material are trace elements of selenium, astaxanthin, citric acid, stearic acid
The mixtures such as magnesium.
(2) load weighted raw material is mixed；
(3) raw material mixed progress tabletting is obtained to the composite probiotics preparations of 100g prophylactic treatment gynecological disease.
Other embodiments
The method for preparing the composite probiotics preparations of 100g prophylactic treatment gynecological disease, comprising the following steps:
(1) raw material is screened, and is weighed in the following proportions: is Freeze-dry Powder of Probioctics 10 ~ 30%, prebiotics 20 ~ 50%, auxiliary
Expect surplus, wherein the Freeze-dry Powder of Probioctics is bifidobacterium longum (Bifidobacterium longum), animal bifidobacteria
Newborn subspecies (Bifidobacteria animalis subsp.lactis), Lactobacillus rhamnosus (Lactobacillus
Rhamnosus), lactobacillus plantarum (Lactobacillus plantarum), lactobacillus paracasei (Lactobacillus
Paracasei) and one of Lactobacillus salivarius (Lactobacillus salivarius) or a variety of, the prebiotics are low
Fructooligosaccharides, inulin, xylo-oligosaccharide, galactooligosaccharide, oligomeric maltose, oligoisomaltose, soyabean oligosaccharides, stachyose, shell
One of glycan, gossypose are a variety of；Viable count >=1 × 10 of the Freeze-dry Powder of Probioctics10/ gram；The auxiliary material be water,
Sodium chloride, wave uric acid, lactose, astaxanthin, converted starch, selenium powder；
(2) load weighted raw material is mixed；
(3) raw material mixed progress tabletting is obtained to the composite probiotics preparations of 100g prophylactic treatment gynecological disease, the prevention
Treat the composite probiotics preparations of gynecological disease application form be capsule, suppository, Disket, gelling agent, paste, pulvis,
Spray, washing lotion, or the form etc. combined with condom, sanitary napkin, panty liner.
Wherein, inorganic selenium sodium selenite, dosage 100-300 microgram/KG product can be selected in selenium；Selenium can also be organic selenium
Or the form addition of active selenium.
The preparation method of the composite probiotics preparations of the prophylactic treatment gynecological disease of above-described embodiment uses a variety of probiotics
In conjunction with, and it is accompanied by prebiotics cooperation, and make the composite probiotics preparations diversification of preparation, it is multiple functional.Compound benefit of the present invention
Raw bacterium all can also be external application with external application, other dosage forms in addition to probiotics powder agent can take orally.Oral powder can rapidly improve
Intestinal flora improves vagina and whole body flora indirectly, promotes whole body health.Other dosage forms pass through different forms, different strain
And prebiotics and auxiliary material are arranged in pairs or groups, and can be effectively improved supplement vagina beneficial bacteria, be balanced vagina pH, reduce harmful bacteria and cause
Germ, to enhancing reproductive system immunity and the general level of the health, prophylactic treatment gynecological disease has remarkable result.According to pre-stage test and
It is on probation, use compound probiotic of the invention, 80% or more the total effective rate of prophylactic treatment gynecological disease.
It chooses the obtained composite probiotics preparations of embodiment 1-7 and capsule, suppository, Disket, gelling agent, cream is respectively prepared
Agent, spray, lotion form, with once a day, quantitatively 3-5g external application every time is used continuously 28 days, for treating 50 with not
With the women of gynecological disease, therapeutic effect is as follows:
| Embodiment | Dosage form | Treat gynecological disease | Use duration | Improver's quantity | Improvement rate |
| Embodiment 1 | Capsule | Vaginitis | Continuous external application 28 days | 44 | 88% |
| Embodiment 2 | Pulvis | Vulvitis | Continuous external application 28 days | 46 | 92% |
| Embodiment 3 | Suppository | Vulvitis | Continuous external application 28 days | 42 | 84% |
| Embodiment 4 | Effervescent tablet | Leukorrhea | Continuous external application 28 days | 39 | 78% |
| Embodiment 5 | Gelling agent | Pelvic inflammatory disease | Continuous external application 28 days | 48 | 96% |
| Embodiment 6 | Paste | Pruritus vulvae | Continuous external application 28 days | 47 | 94% |
| Embodiment 7 | Tablet | Cervicitis | Continuous external application 28 days | 45 | 90% |
It is worth noting that, above-mentioned probiotics composite preparation for caesarean birth, operation auxiliary production puerpera postoperative wound healing,
It is also helpful to reduce wound infection.
Each technical characteristic of embodiment described above can be combined arbitrarily, for simplicity of description, not to above-mentioned reality
It applies all possible combination of each technical characteristic in example to be all described, as long as however, the combination of these technical characteristics is not deposited
In contradiction, all should be considered as described in this specification.
The embodiments described above only express several embodiments of the present invention, and the description thereof is more specific and detailed, but simultaneously
It cannot therefore be construed as limiting the scope of the patent.It should be pointed out that coming for those of ordinary skill in the art
It says, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to protection of the invention
Range.Therefore, the scope of protection of the patent of the invention shall be subject to the appended claims.
Claims (10)
1. a kind of composite probiotics preparations of prophylactic treatment gynecological disease, it is characterised in that: by mass percentage by following components
Composition: Freeze-dry Powder of Probioctics 10 ~ 30%, prebiotics 20 ~ 50%, auxiliary material surplus, wherein the Freeze-dry Powder of Probioctics is long bifid bar
Bacterium (Bifidobacterium longum), bifidobacterium animalis subspecies (Bifidobacteria animalis
Subsp.lactis), Lactobacillus rhamnosus (Lactobacillus rhamnosus), lactobacillus plantarum (Lactobacillus
Plantarum), lactobacillus paracasei (Lactobacillus paracasei) and Lactobacillus salivarius (Lactobacillus
Salivarius one of) or a variety of, the prebiotics are oligofructose, inulin, xylo-oligosaccharide, galactooligosaccharide, oligomeric
One of maltose, oligoisomaltose, soyabean oligosaccharides, stachyose, chitosan, gossypose are a variety of.
2. a kind of composite probiotics preparations of prophylactic treatment gynecological disease according to claim 1, it is characterised in that: described
The deposit number of lactobacillus plantarum (Lactobacillus plantarum) is CGMCC NO.15029.
3. a kind of composite probiotics preparations of prophylactic treatment gynecological disease according to claim 1, it is characterised in that: described
The deposit number of bifidobacterium longum (Bifidobacterium longum) is CGMCC NO.15028.
4. a kind of composite probiotics preparations of prophylactic treatment gynecological disease according to claim 1, it is characterised in that: described
The deposit number of Lactobacillus rhamnosus (Lactobacillus rhamnosus) is CGMCC NO.15027.
5. a kind of composite probiotics preparations of prophylactic treatment gynecological disease according to claim 1, it is characterised in that: described
The deposit number of bifidobacterium animalis subspecies (Bifidobacteria animalis subsp.lactis) is CGMCC
NO.15026, the deposit number of the lactobacillus paracasei (Lactobacillus paracasei) are CGMCC NO.15025,
The deposit number of the Lactobacillus salivarius (Lactobacillus salivarius) is CGMCC NO.15701.
6. a kind of composite probiotics preparations of prophylactic treatment gynecological disease according to claim 1, it is characterised in that: described
Viable count >=1 × 10 of Freeze-dry Powder of Probioctics10/ gram.
7. a kind of composite probiotics preparations of prophylactic treatment gynecological disease according to claim 1, it is characterised in that: described
Auxiliary material is water, sodium chloride, lactose, astaxanthin, converted starch, wave uric acid, gum arabic, glycerol, gelatin, vegetable oil, glycerol
Two or more mixture in ester, citric acid, sodium bicarbonate, selenium and magnesium stearate.
8. a kind of composite probiotics preparations of prophylactic treatment gynecological disease according to claim 1, it is characterised in that: described
Form to the composite probiotics preparations of prophylactic treatment gynecological disease is pulvis, tablet, capsule, suppository, gelling agent, paste, frost
Agent, spray, Disket, effervescent tablet, washing lotion, or the form combined with condom, sanitary napkin, panty liner.
9. a kind of preparation of such as composite probiotics preparations of prophylactic treatment gynecological disease described in any item of the claim 1 to 8
Method, it is characterised in that: the following steps are included:
It is weighed in proportion after the raw material of the composite probiotics preparations of prophylactic treatment gynecological disease is screened；
Load weighted raw material is mixed；
The raw material mixed is carried out to mould molding, the as composite probiotics preparations of prophylactic treatment gynecological disease.
10. a kind of such as composite probiotics preparations of prophylactic treatment gynecological disease described in any item of the claim 1 to 8 are answered
With, it is characterised in that: the following steps are included: composite probiotics preparations are added in sanitary napkin or panty liner.
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| CN110317761A (en) * | 2019-07-23 | 2019-10-11 | 广东益可维健康科技有限公司 | A kind of bifidobacterium lactis and its application |
| CN110373354A (en) * | 2019-07-23 | 2019-10-25 | 广东益可维健康科技有限公司 | One lactobacillus plantarum and its application |
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| CN112806576A (en) * | 2019-10-29 | 2021-05-18 | 锦乔生物科技有限公司 | Composition for inhibiting pathogenic bacteria of vaginitis, vagina cleaning composition and application thereof |
| CN113558246A (en) * | 2021-07-21 | 2021-10-29 | 石河子大学 | Symbiotic bifidobacterium composite microcapsule and preparation method thereof |
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