CN109387419B - Slice manufacturing, dyeing and scanning integrated machine - Google Patents
Slice manufacturing, dyeing and scanning integrated machine Download PDFInfo
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- CN109387419B CN109387419B CN201811480003.4A CN201811480003A CN109387419B CN 109387419 B CN109387419 B CN 109387419B CN 201811480003 A CN201811480003 A CN 201811480003A CN 109387419 B CN109387419 B CN 109387419B
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- slice
- dyeing
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- test tube
- tube seat
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
- G01N1/31—Apparatus therefor
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
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- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
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- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Sampling And Sample Adjustment (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The invention discloses a slice manufacturing, dyeing and scanning integrated machine, which solves the problems of long time consumption and need of matching of operators in the slice manufacturing process in the prior art, and has the effects of being capable of completing dyeing, flushing and air drying operations of slices, automatically scanning and processing the slices and having high integration degree; the technical proposal is as follows: the device comprises a centrifugal device, a positioning and identifying device, an automatic pipetting device, a slicing and moving device, a slice dyeing device and an automatic scanning system, wherein a test tube seat is arranged in the centrifugal device and is connected with a vibration mixing device; the positioning and identifying device comprises a gear intermittent mechanism and a color sensor; the automatic pipetting device comprises an electric pipetting device, wherein the electric pipetting device is driven by the linear movement module to move; the slice moving device is arranged on one side of the linear moving module and comprises a sucker, and the sucker is provided with adsorption force by a pneumatic mechanism; the slice dyeing device comprises a turnover device and an automatic scanning system, and is used for scanning slice information after slice dyeing treatment.
Description
Technical Field
The invention relates to the field of slice manufacturing, in particular to a slice manufacturing, dyeing and scanning integrated machine.
Background
Although the technique for preparing a slice sample is a fundamental technique in biology, the procedure is delicate and complicated due to individual differences in biological materials and diversity in chemical reagents.
The existing slice manufacturing equipment generally needs operators to cooperate, can not finish various operations such as reagent mixing, dripping and dyeing, and has long time consumption, so that the requirements of increasingly developed medicine and biology can not be met.
Disclosure of Invention
In order to overcome the defects of the prior art, the invention provides a slice manufacturing, dyeing and scanning integrated machine which has the effects of being capable of completing the operations of dyeing, flushing and air drying of slices, automatically scanning the slices and processing the slices and having high integration degree.
The invention adopts the following technical scheme:
A slice making, staining and scanning all-in-one machine, comprising:
the centrifugal device is internally provided with a test tube seat, and the test tube seat is connected with a vibration mixing device for uniformly mixing the reagent and the biological sample;
The positioning and identifying device comprises a gear intermittent mechanism for realizing accurate rotation of the test tube seat and a color sensor for identifying the position of the test tube seat;
The automatic pipetting device comprises an electric pipetting device, wherein the electric pipetting device is driven by the linear movement module to move;
the slice moving device is arranged on one side of the linear moving module and comprises a sucker for sucking and placing slices, and the sucker provides adsorption force by a pneumatic mechanism;
the slice dyeing device comprises a turnover device for driving the slice to move, and can realize the operations of dyeing, flushing and air drying of the slice;
And the automatic scanning system is used for scanning and processing the slice after the slice dyeing process.
Further, the vibration mixing device comprises a vibration motor, and the vibration motor is connected with the test tube seat.
Further, the positioning and identifying device is arranged above the centrifugal device and comprises a shell, and the gear intermittent mechanism is arranged inside the shell and is connected with the test tube seat.
Further, the linear movement module comprises a left-right movement device, a front-back movement device connected with the left-right movement device, and a up-down movement device connected with the front-back movement device.
Further, two up-down moving devices are respectively connected with the automatic pipetting device and the slicing moving device.
Further, the pneumatic mechanism comprises an air pump, the air pump is connected with the sucker through a conduit, and a three-way electromagnetic valve for controlling the flow of air is arranged on the conduit.
Further, a vacuum generator and a vacuum filter are arranged between the three-way electromagnetic valve and the air pump.
Further, dye the piece device and include a plurality of piece grooves that dye, turning device installs in dye piece groove top, and it includes a plurality of upset grooves, the upset groove passes through the turning arm and links to each other with the upset steering wheel.
Further, a piece dropping groove, an air drying groove, a flushing groove, a slicing cabin, a glass slide cabin and a reagent supply device are arranged on the side face of the piece dyeing groove.
Further, a water pump is arranged in the flushing tank, and a fan is arranged in the air drying tank.
Compared with the prior art, the invention has the beneficial effects that:
(1) The centrifugal device is matched with the positioning recognition device, so that the biological sample and the reagent contained in the test tube can be fully mixed, and the accuracy is improved;
(2) The invention is provided with the linear movement module, and can realize automatic movement of the electric drip and the sucker, thereby realizing drip operation and automatic movement operation of the slice without manual intervention, and having high degree of automation.
Drawings
The accompanying drawings, which are included to provide a further understanding of the application and are incorporated in and constitute a part of this specification, illustrate embodiments of the application and together with the description serve to explain the application.
FIG. 1 is an isometric view of the present invention;
FIG. 2 is a front view of the present invention;
FIG. 3 is a top view of the present invention;
FIG. 4 is a side view of the present invention;
FIG. 5 is a schematic diagram of a mobile device according to the present invention;
FIG. 6 is a schematic view of an automatic pipetting device of the invention;
FIG. 7 is a schematic view of a centrifugal apparatus according to the present invention;
FIG. 8 is a schematic diagram of a positioning and identifying device according to the present invention;
FIG. 9 is a top view of the drop dyeing apparatus of the present invention;
FIG. 10 is a front view of the drop dyeing apparatus of the present invention;
FIG. 11 is a side view of the drop dyeing apparatus of the present invention;
FIG. 12 is a schematic view of the structure of the capsule according to the present invention;
FIG. 13 is a schematic view of a slide bay structure of the present invention;
The device comprises a 1-automatic scanning system, a 2-centrifugal device, a 3-left-right moving device, a 4-front-back moving device, a 5-up-down moving device, a 6-dyeing device, a 7-positioning identification device, an 8-electric pipettor, a 9-automatic pipetting device, a 10-glass slide cabin, a 11-dropping slice tank, a 12-touch screen integrated machine, a 13-slicing cabin, a 14-dyeing slice tank, a 15-reagent supply device, a 16-vibration mixing device, a 17-cover plate, a 18-turning arm, a 19-turning steering engine, a 20-air drying tank, a 21-flushing tank, a 22-air pump, a 23-vacuum filter, a 24-gear, a 25-vacuum generator, a 26-three-way electromagnetic valve, a 27-sucker, a 28-centrifugal rotor, a 29-vibration motor, a 30-test tube, a 31-test tube seat, a 32-centrifugal cabin, a 33-step motor, a 34-tooth wheel disc, a 35-color sensor, a 36-shell and 37-Yan Sepan.
Detailed Description
It should be noted that the following detailed description is illustrative and is intended to provide further explanation of the application. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs.
It is noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of exemplary embodiments according to the present application. As used herein, the singular is also intended to include the plural unless the context clearly indicates otherwise, and furthermore, it is to be understood that the terms "comprises" and/or "comprising" when used in this specification are taken to specify the presence of stated features, steps, operations, devices, components, and/or combinations thereof.
As described in the background art, the prior art has the defects of long time consumption and need of matching by operators in the slice manufacturing process, and in order to solve the technical problems, the application provides a slice manufacturing, dyeing and scanning integrated machine.
In an exemplary embodiment of the present application, as shown in fig. 1 to 13, a slice making, dyeing and scanning integrated machine is provided, which comprises a centrifugal device 2, a positioning and identifying device 7, an automatic pipetting device 9, a slice moving device, a slice dyeing device 6 and an automatic scanning system 1.
Wherein, automatic pipetting device 9, section mobile device install in dye piece device 6 top, and centrifugal device 2 locates dye piece device 6 one side, and location recognition device 7 installs in dye piece device 6 top, and automatic scanning system 1 is located dye piece device 6 opposite side.
The centrifugal device 2 adopts a centrifugal machine, as shown in fig. 7, and comprises a centrifugal cabin 32, wherein a cover plate 17 is arranged at the top of the centrifugal cabin 32; the centrifugal cabin 32 is internally provided with a centrifugal rotor 28, the centrifugal rotor 28 is connected with a test tube seat 31, and the test tube seat 31 is driven to rotate by the rotation of the centrifugal rotor 28.
The test tube seat 31 has a plurality ofly, including the center pillar, a plurality of symmetric distribution's pedestal is connected to the center pillar circumference, the pedestal has been seted up and has been used for placing test tube 30's through-hole.
After the reagent is added into the biological sample in the test tube 30, in order to increase the contact area of the reagent with the sample, the mixing of the biological sample and the reagent needs to be accelerated; therefore, the cuvette holder 31 is provided with the vibration mixing device 16, and the vibration mixing device 16 can uniformly mix the reagent and the sample in the cuvette 30 mounted in the cuvette holder 31.
Further, the vibration mixing device 16 is a vibration motor 29.
When the sample in the test tube 30 is centrifuged, the motor in the centrifuge is difficult to accurately transfer the test tube holder 31 to a specific angle, and the position of the test tube 30 cannot be identified after centrifugal rotation, so that the reagent is not easy to be added into the test tube 30.
Therefore, the positioning and identifying device 7 is arranged above the centrifugal device 2, the positioning and identifying device 7 is shown in fig. 8, the positioning and identifying device comprises a shell 36, and a gear intermittent mechanism is arranged in the shell 36 and is connected with the middle upright post of the test tube seat 31, so that the precise rotation of the test tube seat 31 is realized.
The intermittent gear mechanism comprises a stepping motor 33, a gear 24 and a gear disc 34, wherein the stepping motor 33 is connected with the gear 24, and the gear 24 is meshed with the gear disc 34.
And a Yan Sepan is arranged above the gear plate 34, a color sensor 35 is arranged on the color plate 37, and the position of the test tube seat 31 is identified through the color sensor 35 so as to meet the requirement of subsequent processing.
The automatic pipetting device 9 and the slice moving device realize automatic movement through a linear moving module, and the linear moving module comprises a left-right moving device 3 (X-axis direction), a front-back moving device 4 (Y-axis direction) and a up-down moving device 5 (Z-axis direction), so that the automatic pipetting device 9 and the slice moving device can move along the X-axis, the Y-axis and the Z-axis directions.
There are two up-and-down moving means 5, one for mounting the automatic pipetting device 9 and the other for mounting the slice moving device.
The left-right moving device 3, the front-back moving device 4 and the up-down moving device 5 adopt linear guide rail mechanisms.
In some embodiments, the linear guide mechanism is a ball screw linear guide.
Since serum generated before and after centrifugation of the biological sample is removed in time, the automatic moving device 9 is required to add a reagent into the test tube 30 according to the experimental treatment progress and drop the centrifuged biological sample onto a slide glass.
The automatic pipetting device 9 comprises an electric pipetting device 8, the accurate suction and the dripping of liquid are realized through the electric pipetting device 8, and the up-and-down movement of the electric pipetting device 8 is realized through a linear movement module.
The slice moving device comprises a sucker 27 and a pneumatic mechanism, wherein the sucker 27 is provided with adsorption force by the pneumatic mechanism.
The pneumatic mechanism comprises an air pump 22, a vacuum generator 25, a vacuum filter 23, a conduit and a three-way electromagnetic valve 26, wherein the air pump 22 is connected with a sucker 37 through the conduit, and the three-way electromagnetic valve 26 for controlling the air flow is arranged on the conduit.
The vacuum generator 25 and the vacuum filter 26 are installed between the three-way electromagnetic valve 26 and the air pump 22.
The slice dyeing device 6 comprises a turnover device, a slice dyeing groove 14, a slice dripping groove 11, an air drying groove 20, a flushing groove 21, a slice cabin 13, a glass slide cabin 10 and a reagent supply device 15.
As shown in fig. 9-11, the dye vat 14 is arranged in a plurality of rows and columns, and the turning device is installed above the dye vat 14.
The turnover device comprises a turnover groove, a turnover arm 18 and a turnover steering engine 19, wherein the turnover groove is connected with the turnover steering engine 19 through the turnover arm 18.
The notch of the turnover groove is matched with the size of the slice.
The slicing chamber 13 is disposed at the rear side of the slice dyeing groove 14, and is used for storing chromosome slices, and is arranged in a plurality of rows and columns, as shown in fig. 12.
The slide compartment 10 is disposed at one side of the slicing compartment 13, and one or more slide compartments may be disposed, as shown in fig. 13, and U-shaped grooves are formed at both sides of the slide compartment 10.
The front side of the slide cabin 10 is provided with a plurality of rows of slide drip grooves 11 which can be used for placing slides to drip samples.
An air drying groove 20 and a flushing groove 21 are arranged between the dropping groove 11 and the dyeing groove 14.
The flushing tank 21 is provided with a water pump, which can spray clean water for flushing the slices.
The air drying tank 20 is provided with a fan, and can blow out dry air to realize air drying of the slices.
The front side of the drip groove 11 is provided with a reagent supply device 15, and the reagent supply device 15 comprises a plurality of closed containers for containing different liquid reagents, and when the liquid is needed to be used, the reagents are taken out from the containers for experiment.
The closed container is connected with the liquid taking pipe, the electromagnetic valve is arranged in the liquid taking pipe and used for adjusting the flow of the reagent, and the capacity of flowing out liquid is detected through the photoelectric sensor, so that the requirement of experimental dosage can be met, and the reagent can be prevented from volatilizing to the greatest extent.
The slices after the dropping of the application are horizontally placed in each dyeing tank 14 through the slice moving device, the turning device drives the turning arm 18 to enable the slices in the turning tank to be perpendicular to the operation surface through the turning steering engine 19, and a part of the slices are soaked in the dyeing tank containing the dyeing liquid.
After a period of soaking, the turning device drives the turning arm 18 to be parallel to the operation surface again through the turning steering engine 19, then the slice moving device places the slice into the flushing groove 21 for flushing, and the slice is placed into the air drying groove 20 for air drying after flushing.
After the above steps are completed, the stained sections are placed in the section chamber 10.
The automatic scanning system 1 is used for scanning the manufactured section, and comprises a microscope, wherein the microscope is in the prior art and is not described herein.
The front side of the automatic scanning system 1 is provided with a touch screen integrated machine 12 which is provided with a chromosome image acquisition module, a storage module and an analysis module and is used for analyzing data after the cutting scanning.
The application also includes a thermostat for ensuring that the chromosome analysis process is at a constant temperature.
The thermostat adopts the existing mechanism and will not be described here again.
The above description is only of the preferred embodiments of the present application and is not intended to limit the present application, but various modifications and variations can be made to the present application by those skilled in the art. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application should be included in the protection scope of the present application.
Claims (7)
1. The utility model provides a section preparation dyeing and scanning all-in-one which characterized in that includes:
the centrifugal device is internally provided with a test tube seat, and the test tube seat is connected with a vibration mixing device for uniformly mixing the reagent and the biological sample;
The positioning and identifying device comprises a gear intermittent mechanism for realizing accurate rotation of the test tube seat and a color sensor for identifying the position of the test tube seat; the positioning and identifying device is arranged above the centrifugal device and comprises a shell, and the gear intermittent mechanism is arranged in the shell and connected with the middle upright post of the test tube seat, so as to realize accurate rotation of the test tube seat; the gear intermittent mechanism comprises a stepping motor, a gear and a gear disc, wherein the stepping motor is connected with the gear, and the gear is meshed with the gear disc; yan Sepan is arranged above the gear plate, a color sensor is arranged on the color plate, and the position of the test tube seat is identified through the color sensor;
The automatic pipetting device comprises an electric pipetting device, wherein the electric pipetting device is driven by the linear movement module to move;
the slice moving device is arranged on one side of the linear moving module and comprises a sucker for sucking and placing slices, and the sucker provides adsorption force by a pneumatic mechanism;
the slice dyeing device comprises a turnover device for driving the slice to move, and can realize the operations of dyeing, flushing and air drying of the slice;
the automatic scanning system is used for scanning and processing the slice after the slice dyeing processing;
The slice dyeing device comprises a plurality of slice dyeing grooves, a turnover device is arranged above the slice dyeing grooves and comprises a plurality of turnover grooves, the turnover grooves are connected with a turnover steering engine through turnover arms, and the notch formed in the turnover grooves is matched with the slice size;
The side of the slice dyeing groove is provided with a slice dripping groove, an air drying groove, a flushing groove, a slice cabin, a glass slide cabin and a reagent supply device.
2. The integrated machine for producing, dyeing and scanning slices according to claim 1, wherein the vibration mixing device comprises a vibration motor, and the vibration motor is connected with the test tube seat.
3. The integrated machine for slice manufacturing, dyeing and scanning according to claim 1, wherein the linear movement module comprises a left-right movement device, a front-back movement device connected with the left-right movement device, and a up-down movement device connected with the front-back movement device.
4. A slice manufacturing, dyeing and scanning integrated machine according to claim 3, wherein the number of the up-and-down moving devices is two, and the up-and-down moving devices are respectively connected with the automatic pipetting device and the slice moving device.
5. The integrated slice manufacturing, dyeing and scanning machine according to claim 1, wherein the pneumatic mechanism comprises an air pump, the air pump is connected with the suction cup through a conduit, and a three-way electromagnetic valve for controlling the air flow is arranged on the conduit.
6. The integrated machine for producing, dyeing and scanning slices according to claim 5, wherein a vacuum generator and a vacuum filter are arranged between the three-way electromagnetic valve and the air pump.
7. The integrated slice manufacturing, dyeing and scanning machine according to claim 1, wherein a water pump is arranged in the flushing tank, and the air drying tank is provided with a fan.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811480003.4A CN109387419B (en) | 2018-12-05 | 2018-12-05 | Slice manufacturing, dyeing and scanning integrated machine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811480003.4A CN109387419B (en) | 2018-12-05 | 2018-12-05 | Slice manufacturing, dyeing and scanning integrated machine |
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| Publication Number | Publication Date |
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| CN109387419A CN109387419A (en) | 2019-02-26 |
| CN109387419B true CN109387419B (en) | 2024-06-28 |
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| CN201811480003.4A Active CN109387419B (en) | 2018-12-05 | 2018-12-05 | Slice manufacturing, dyeing and scanning integrated machine |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111056309A (en) * | 2019-12-31 | 2020-04-24 | 盐城市艾琪儿妇产医院有限公司 | Obstetrical pathological section removes handling device |
| CN112345317B (en) * | 2020-09-09 | 2022-09-27 | 安徽九陆生物科技有限公司 | Liquid-based cell slide scanning and reading mechanism and using method thereof |
| CN112221725B (en) * | 2020-09-24 | 2022-04-22 | 湖北中医药高等专科学校 | Vacuum test analysis device for clinical laboratory |
| CN113820193A (en) * | 2021-08-05 | 2021-12-21 | 南京市口腔医院 | Device and method for treating oral squamous carcinoma in-vitro tumor tissue specimen and application |
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| CN109387419A (en) | 2019-02-26 |
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