CN109364377A

CN109364377A - A device for realizing internal field intensity focusing of non-metallic effectors in irradiation cavity

Info

Publication number: CN109364377A
Application number: CN201811137271.6A
Authority: CN
Inventors: 朱湘琴; 陈昌华; 杜太焦; 胡龙; 蔡利兵; 郑奎松
Original assignee: Northwest Institute of Nuclear Technology
Current assignee: Northwest Institute of Nuclear Technology
Priority date: 2018-09-27
Filing date: 2018-09-27
Publication date: 2019-02-22
Anticipated expiration: 2038-09-27
Also published as: CN109364377B

Abstract

The invention provides a device for realizing the focusing of the internal field intensity of the non-metallic effector in the irradiation cavity, which can efficiently improve the local focusing of the field intensity of the effector in the irradiation cavity. The device includes an irradiation cavity and an effector placed in the irradiation cavity. The irradiation cavity has upper and lower metal plates; a local area of the irradiation cavity around the effector is filled with a homogeneous medium, and the relative medium of the homogeneous medium is filled with a homogeneous medium. The electric constant is between the relative permittivity of air and the effector; one of the upper and lower metal plates has a tip formed by bending, and the tip is close to the homogeneous medium and corresponds to the focus position of the effector. The field intensity focusing method of the present invention can take into account the slow transition of the relative dielectric constant of the medium and the local enhancement of the current at the metal tip, so that the field inside the effector in the irradiation cavity achieves the effect of focusing.

Description

It is a kind of to realize the device for irradiating intracavitary nonmetallic effector fields inside strong-focusing

Technical field

The present invention relates to a kind of realize to irradiate the device of intracavitary nonmetallic effector fields inside strong-focusing.

Background technique

Blood-brain barrier (blood-brain barrier, BBB) structure is that intracerebral structure is the most complicated, effect is mostly important One of barrier, by the endothelial cell of capillary and capilary, pericyte, basement membrane and astroglia common group of foot eventually At to the various substances in blood circulation with the stringent penetrating mechanism of selection, the high stability of guarantee intracerebral environment is with benefit In the functional activity of central nervous system.However BBB invades brain tissue in prevention foreign matter (including microorganism, virus etc.) and obtains While protective effect, also therapeutic agent being prevented to enter cerebral lesion region, (Kangchu Li et al. people is published in Volume 39 page 60 of " Bioelectromagnetics " periodical 2018, " EMP-induced BBB-disruption enhances drug delivery to glioma and increases treatment efficacy in rats”)。 Therefore, for central nervous system disease, drug effectively absorb because BBB there are due to be difficult to realize, seriously constrain brain Effective implementation of the drug therapy of illness.And according to years of researches it is found that the irradiation of strong electromagnetic pulse can produce significantly Biological effect (Mingjuan Yang et al. is published in volume 80 page 18 of " Theriogenology " periodical 2013, " Effects of electromagnetic pulse on polydactyly of mouse fetuses "), it can open (Wang Qi et al. is published in " disease control magazine " periodical 2003 volume 7 to drug absorption of the BBB structure to complete lesion region 5th phase page 404, " dose-effect relationship that pulsed electromagnetic radiation influences blood brain barrier of rats ").

On the other hand, (Zhou Bihua et al. is published in " electric wave science journal " periodical 2011 to structure with Bounded-wave Simulator The phase page 1034 of volume 26 the 6th, the calibration of Lightning Electromagnetic Pulse electric field instrument " study ") identical irradiation chamber can be in working space Uniform field is provided.Therefore, when by be used as effector human brain or animal brain be put into irradiation it is intracavitary when, in order to open brain The BBB structure of lesion region (i.e. the regional area of effector) needs to carry out the regional area focusing of field strength, so that The region receives the irradiation of strong electromagnetic pulse.Therefore, it is necessary to study intracavitary effector field strength focus method is irradiated.

Summary of the invention

The present invention proposes a kind of device realized and irradiate intracavitary nonmetallic effector fields inside strong-focusing, can efficiently be promoted Irradiate the local focal of intracavitary effector field strength.

Applicant has found when research irradiates intracavitary effector fields inside strong-focusing method, when small using relative dielectric constant The enhanced intensity when uniform dielectric of effector relative dielectric constant is to be locally filled with, in effector；When irradiation chamber work is empty Between upper parallel metal sheet under notch distortion when, the phenomenon that live local enhancement is gone out near sagging tip.By both above-mentioned knot Merge and propose a kind of new approaches for irradiating field strength local focal inside intracavitary effector based on three-dimensional numerical simulation result, The slow transition of medium relative dielectric constant can be taken into account, at metal tip electric current local enhancement so that field strength in effector The advantages of local enhancement.

The present invention is locally filled with by uniform dielectric, realizes the increasing for entering the energy inside nonmetallic effector Add；Simultaneously by the deformation of metal polar plate, so that the field local enhancement near deformed tip, so that somewhere inside effector There is field strength focusing phenomenon.

Specific solution of the invention is as follows:

The device includes irradiating chamber and being placed in irradiate intracavitary effector, and irradiation chamber has upper and lower metal polar plate；Effect The intracavitary regional area of irradiation around object is filled with uniform dielectric, and the relative dielectric constant of the uniform dielectric is between air and effect It answers between the relative dielectric constant of object；One of described upper and lower metal polar plate has the tip being bent to form, and the tip is close to described Uniform dielectric and the focal position for corresponding to (preferably front is directed toward) effector.

Based on above scheme, the present invention has also further made following optimization:

The effector is in eccentric setting in uniform dielectric, so that the focal position of effector is closer to the tip.

The volume of laying effect object is v, then the volume of the uniform dielectric is 55~65v；Effector is to electromagnetic wave incident side Distance to the uniform dielectric surface (i.e. left-hand face in figure) of side is 50~60mm；The outer surface of effector to tip side The minimum distance on uniform dielectric surface (i.e. upper surface in figure) be 21~23mm, the distance on the surface to tip for 10~ 15mm；Focal position in effector is no more than 50mm at a distance from tip.

The radiation entrance region of irradiation chamber is set as beloid preceding changeover portion, so that electromagnetic wave is produced by preceding changeover portion When giving birth to the spherical wave of approaches uniformity, then reaching the working space of irradiation chamber, the uniform field of vertical polarization is formed in working space.

The invention has the benefit that

Local uniform media filler avoids conventional scheme in the intracavitary formation Uniform Electromagnetic Field of irradiation and is directly incident on effect Object, it is difficult to which the problem of effectively realizing the localized clusters of effector self-energy realizes the aggregation for the energy being incident in effector.

There is tip point in notch distortion under working space top crown, the phenomenon that electric current local enhancement occurs at the tip, thus There is the effect of field strength local enhancement near tip.

The above both sides combines, and enables the field strength type of focusing of the invention to take into account medium relative dielectric constant slow Electric current local enhancement at transition, metal tip realizes the effect of focusing so that irradiating the field inside intracavitary effector.

Detailed description of the invention

Fig. 1 is that have nonmetallic effector, be locally filled with metal plate on insulation uniform dielectric and irradiation chamber around effector Sagging side view.

In figure, the feed location of 1. irradiation chambers, 2. irradiate changeover portion before chambers, the sagging upper pole of 3. irradiation chamber working spaces Plate, the sagging tip of 4. top crowns, the bottom crown of 5. irradiation chamber working spaces, 6. irradiate changeover portion after chambers, 7. nonmetallic effects Object, the uniform dielectric being locally filled with around 8. effectors, 9. are located at the test point (effect in the effector immediately below tip of sinking The focal position of object).

Specific embodiment

With reference to the accompanying drawing, by embodiment, the present invention is further described.

One aspect of the present invention is less than using relative dielectric constant irradiates the exhausted of intracavitary nonmetallic effector relative dielectric constant Edge medium, to be locally filled with the surrounding space near effector, i.e. the relative dielectric constant for the medium of filling is greater than air Dielectric constant, but be less than effector dielectric constant.When electromagnetic wave is from driving source, the preceding changeover portion by irradiating chamber is produced When having given birth to the spherical wave of approaches uniformity, then having reached the working space of irradiation chamber, the uniform of vertical polarization is formd in working space , when the uniform field penetrates the medium of filling, reaches effector surface again, due to being slowly increased for medium relative dielectric constant Transition change, compared with no media filler, there is enhancing phenomenon in the transmitted wave in entrance effect object.On the other hand, by spoke Lower notch distortion is carried out according to the upper metal polar plate of chamber working space, is forming tip point above the position that medium is locally filled with. For electromagnetic wave during irradiating intracavitary transmission, constituting on the inner surface of the upper metal polar plate of irradiation chamber working space has surface Electric current exists；When notch distortion under the pole plate, at tip, there is current concentrated phenomenon in point, so as to cause electric field near tip Local enhancement.Above-mentioned uniform dielectric is locally filled with and is combined with notch distortion under upper metal plate, so that it may so that irradiating intracavitary effect The field inside object is answered enhancing phenomenon occur.Therefore, it is slow can to take into account medium relative dielectric constant to the field strength type of focusing of the invention Electric current local enhancement at slow transition, metal tip is so that the advantages of field strength local enhancement in effector.

Specific structure as shown in Figure 1: the height of irradiation chamber working space is 500mm；The top crown of working space 2/5~ It sink at 3/5 position；Effector is made of the dielectric cylinder that the medium hemisphere and length of radius 15mm are 165mm, the phase of medium It is 50 to dielectric constant；The centre of sphere for constituting the hemisphere of effector is located at the underface at tip of sinking, the centre of sphere and working space it is upper Vertical range between pole plate is 217mm, and the vertical range with sagging tip is 50mm, selects the centre of sphere for test point；Effect Be filled with around object the direction x, y and z (perpendicular to the direction of the paper i.e. direction z in figure) size be respectively 250mm, 150mm and The uniform dielectric of 200mm, the ratio between volume and the volume of effector of uniform dielectric are 60.63；Effector is to electromagnetic wave incident side Distance to the uniform dielectric surface (i.e. left-hand face in figure) of side is 57.5mm, the outer surface to tip side of effector The minimum distance on uniform dielectric surface (i.e. upper surface in figure) is 22mm, the upper surface of uniform dielectric between tip it is vertical away from It is 8 from the relative dielectric constant for 13mm, filled media.

The process of test effect of the present invention is as follows: (1) height for being about 120MHz plus highest frequency in the front end of irradiation chamber It is intracavitary to be placed into conventional irradiation by this pulse for effector；(2) uniform dielectric is filled into around effector, is surveyed in effector The peak value of point electric field becomes 1.5 times when no media filler；(3) on the basis of (2), then the upper gold that chamber working space will be irradiated Belong to pole plate and carry out lower notch distortion, the peak value of measuring point electric field at least becomes no media filler and sink without pole plate to become in effector at this time 3.6 times or more when shape, to realize the realization of effector inner focusing.

Specification of the invention gives sufficient explanation to summary of the invention, and the design parameter of each component can basis Actual demand setting, the content that those of ordinary skill is enough specification through the invention are implemented.In the frame of claim Under, any improvement based on thinking of the present invention belongs to the protection scope of present patent application.

Claims

1. a device for realizing the focusing of the internal field strength of a non-metallic effector in an irradiation cavity, comprising an irradiation cavity and an effector placed in the irradiation cavity, and the irradiation cavity has upper and lower metal plates; it is characterized in that: The local area in the irradiation cavity around the effector is filled with a homogeneous medium, and the relative permittivity of the homogeneous medium is between the relative permittivity of air and the effector; one of the upper and lower metal plates has a curved surface. folded to form a tip that is close to the homogeneous medium and corresponds to the focal position of the effector.

2 . The device according to claim 1 , wherein the effector is eccentrically arranged in a homogeneous medium, so that the focusing position of the effector is closer to the focus of the effector. 3 . mentioned tip.

3. The device for realizing the focusing of the internal field intensity of a non-metallic effector in an irradiation cavity according to claim 1, wherein: if the volume of the effector is v, the volume of the uniform medium is 55-65v; The distance from the object to the uniform medium surface on the side of the incident direction of the electromagnetic wave is 50-60 mm; the closest distance from the outer surface of the effector to the uniform medium surface on the tip side is 21-23 mm, and the distance from the uniform medium surface to the tip is 10 mm. ~15mm; the focus position within the effector is no more than 50mm from the tip.

4. The device for realizing the internal field intensity focusing of the non-metallic effector in the irradiation cavity according to claim 1, wherein the radiation entrance area of the irradiation cavity is set as a front transition section with a narrow front and a wide front, so that the electromagnetic waves pass through The front transition section generates an approximately uniform spherical wave, and when it reaches the working space of the irradiation cavity, a uniform field of vertical polarization is formed in the working space.