CN109350842B - Roller of penetration-promoting pen and metal sheet thereof, penetration-promoting pen - Google Patents
Roller of penetration-promoting pen and metal sheet thereof, penetration-promoting pen Download PDFInfo
- Publication number
- CN109350842B CN109350842B CN201811303499.8A CN201811303499A CN109350842B CN 109350842 B CN109350842 B CN 109350842B CN 201811303499 A CN201811303499 A CN 201811303499A CN 109350842 B CN109350842 B CN 109350842B
- Authority
- CN
- China
- Prior art keywords
- metal sheet
- roller
- penetration
- mounting shaft
- pen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0053—Methods for producing microneedles
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Medical Informatics (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Radiation-Therapy Devices (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
本发明公开了一种促渗笔的滚轮及其金属片、促渗笔。所述金属片上设有第一安装孔以及连通所述第一安装孔与所述金属片外圆周面的第一缺口，所述金属片的外圆周面上按照设定间距设有多个围绕所述金属片圆心设置的微针，所述微针的自由端为易于刺入皮肤的锐利的针尖，所述金属片利用电火花线切割加工而成。根据本发明实施例的金属片外圆周的外径尺寸、微针长度和针尖的尖角与针尖间距都能够做的很小，加工精度高、一致性好、能够节能环保的实现批量生产，采用该金属片的促渗笔纤细小巧、便于操作与携带，促渗效果显著且更加安全。
The present invention discloses a roller of a penetration-enhancing pen, a metal sheet, and a penetration-enhancing pen. The metal sheet is provided with a first mounting hole and a first notch connecting the first mounting hole and the outer circumferential surface of the metal sheet. The outer circumferential surface of the metal sheet is provided with a plurality of microneedles arranged around the center of the metal sheet according to a set interval. The free end of the microneedle is a sharp needle tip that is easy to penetrate the skin. The metal sheet is processed by electric spark wire cutting. According to the embodiment of the present invention, the outer diameter of the outer circumference of the metal sheet, the length of the microneedle, the sharp angle of the needle tip and the needle tip spacing can all be made very small, with high processing accuracy, good consistency, and can be mass-produced in an energy-saving and environmentally friendly manner. The penetration-enhancing pen using the metal sheet is slender and compact, easy to operate and carry, and has a significant penetration-enhancing effect and is safer.
Description
Technical Field
The invention relates to the field of beauty and medical appliances, in particular to a metal sheet of a penetration promoting pen, a roller with the metal sheet and the penetration promoting pen.
Background
For a long time, most of medicines or skin care products with the functions of treatment, health care or beauty maintenance and the like are difficult to achieve expected curative effect due to the too low percutaneous permeation rate due to the blocking effect of the stratum corneum on the outer surface of the skin. In recent years, a method for massaging and promoting permeation of skin by adopting a permeation promoting instrument based on a microneedle roller has received general attention. The roller of the permeation promoting device is uniformly distributed with a microneedle array consisting of hundreds of microneedles, a large number of micro-scale pore channels can be instantaneously formed on the skin stratum corneum and the epidermis layer by a needle application mode of the pressing and rolling device, and then medicines or beauty skin care products are coated, so that the permeation capacity of active substances penetrating through the stratum corneum into the epidermis layer can be greatly improved, and the effects of medicine effect or beauty skin care are expected to be remarkably improved.
Disclosure of Invention
The inventor of the present invention studied various permeation promotion devices based on microneedle rollers existing in the market, found that the permeation promotion devices in the related art have the following structure and disadvantages, and the microneedle array on the existing microneedle roller is used as a core element of the device and mainly has two structural forms:
one is to uniformly penetrate and fix hundreds of discrete stainless steel needles on a strip-shaped plastic substrate and then assemble the stainless steel needles. The smaller the length of the single needle and the distance between the needles, the greater the difficulty of processing and assembling processes, the obviously reduced uniformity, repeatability and yield of the array, and the higher the cost, the larger the outer diameter size (about 20 mm) of the microneedle roller and the distance (about 2 mm) between the needle tips protruding from the surface of the plastic substrate are, and the length of the protruding needle tips is 0.25-1.5 mm.
The other is formed by alternately assembling a plurality of annular metal sheets and annular gaskets, wherein tens of protruding micro-needles are uniformly distributed in the radial direction around the outer ring of the annular metal sheets prepared by a laser cutting method. The outside diameter of the roller/pad of such commercially available penetration enhancers is typically about 20 mm, the tip spacing between adjacent microneedles on a circular sheet metal can currently be reduced to 1.4 mm, but the distance between adjacent circular sheets, i.e., the thickness of the circular pad, is typically about 2 mm.
Through investigation and analysis, the existing microneedle roller permeation promotion instrument assembled by using the circular metal sheet prepared based on the laser cutting method has the following main problems:
First, the spacing between the tips is relatively large, approximately 1.4 millimeters. Under the limitation of laser processing precision and minimum processing size, under the condition of adopting enough laser power to ensure cutting efficiency, the line of a laser cutting line is generally wider, the cutting precision is rapidly reduced along with the increase of the thickness of a metal sheet, and in order to rapidly cut out a needle point with sharp and uniform structure on the metal sheet with a certain thickness, the length of a micro needle and the distance between the needle points are difficult to be made small. The existing circular metal sheet with the thickness of 100 micrometers has the length of 2.5 millimeters only for the protruding microneedles on the outer circumferential surface, so that the distance between the needle tips of adjacent microneedles is larger, and the density of the microneedle array is smaller. Therefore, the pinhole density can be increased only by repeatedly rolling on the skin surface to achieve the declared permeation promoting effect, so that effective control of the perforation density and uniformity of the skin is difficult to realize, and even local skin is damaged due to overlarge pinhole density.
Second, the outer diameter of the roller is relatively large, typically about 20 mm. The skin of the human body, particularly the facial skin, is very soft, delicate and uneven, and the eyes and their peripheral parts are particularly delicate, and once injured, the consequences cannot be assumed. Because the outer diameter of the microneedle roller of the conventional permeation promotion instrument is larger, the width of the roller is almost the same as the outer diameter, only a small part of the microneedles can actually touch the skin when the roller is used, and the skin at some parts can not touch the microneedles at all, so that the roller has low utilization rate, a uniform permeation promotion effect is difficult to obtain, and key parts such as eyes are easy to be injured. In addition, the large-size microneedle roller machine needs a large-size operating handle and a larger-size machine protection structure, so that the whole permeation promoting machine is large in size, heavy and inconvenient to carry.
Third, the length of the tip protruding from the roller/pad is longer, about 0.25-1.5 mm. For convenience of manufacturing and quality control, the length of the microneedle protruding from the outer circumferential surface of the conventional circular ring-shaped metal sheet is usually set to about 2.5 mm, so that it is necessary to adjust the length of the tip of the protruding roller/pad by using a circular ring-shaped pad having a larger outer diameter and by changing its size. The blocking effect of the stratum corneum with the thickness of about 10-40 microns on the outer surface of human skin is a main reason for the too low percutaneous permeation rate of most medicaments or skin care products, so long as the microneedle length can puncture the stratum corneum and is not deep enough to the facial nerves and capillaries, the administration rate or the cosmetic effect can be obviously improved, and the needle can not feel pain or cause bleeding during needle application, and is definitely safer and more reliable. On the contrary, if the microneedle is too long, the pain is strong, bleeding is easy to occur and the infection is easy to occur, and the rolling microneedle breaks facial tissues to cause larger damage, so the microneedle is suspected to be destroyed.
In addition, the black oxide skin and a large amount of convex metal slag or burrs are generated on the surface near the notch when the metal such as stainless steel, titanium and the like is cut by adopting laser, and the black oxide skin and a large amount of convex metal slag or burrs are removed by adopting a series of subsequent corrosion and cleaning processes such as acid washing, electrochemical polishing and the like, so that the production environment-friendly requirement is not facilitated, and the processing precision is also influenced; because the laser cutting method is adopted for preparation, the distance between the outer circumferential surface of the circular ring-shaped metal sheet and the needle points protruding from the circular ring-shaped metal sheet is larger, and most areas between the needle points are deeply sunk between the two circular ring-shaped gaskets and are difficult to clean, so that potential safety hazards are brought.
In short, the inventor has conducted extensive and intensive investigation on the permeation enhancer in the related art, and found that the actual use effect of the permeation enhancer often has a great difference from the expected massage permeation enhancer, and the safety of the permeation enhancer also has a lot of controversies, and people still generally have a sightedness for the permeation enhancer. In addition, the penetration promoting devices in the related art are mainly limited to various beauty parlors to be matched with gunpowder for use, and are operated by professionals, and the effect is generally praise or blame in half according to the technical level of operators.
Compared with the laser cutting method, the wire-cut electric discharge machining method has unique advantages in micro-machining of deep and narrow grooves on various metals, can achieve ultra-high accuracy of micron level and very high surface quality, can obtain a mirror surface with roughness ra=0.1 micron at maximum, and does not generate various burrs such as oxide layers, protruding metal slag and the like in the notch, so that additional special surface treatment is not needed. However, the wire-cut electric discharge machine cannot be directly used for punching or processing metal structures in holes, and other methods are needed to be used for punching through holes for threading on a workpiece, then molybdenum wires or copper wires serving as cutting electrodes on the wire-cut electric discharge machine are threaded through the through holes on the workpiece, and then the wires are threaded again and aligned for processing materials around the through holes. If the wire cut electric discharge machine is used to machine the circular metal sheet with the micropins around the outer ring, a series of procedures such as punching, threading, repeated disassembly and assembly of molybdenum wires or copper wires and the like are required to be continuously replaced, which is quite time-consuming, labor-consuming, low in work efficiency and difficult to realize low-cost mass production.
Therefore, on the premise that the inventor carries out extensive and intensive investigation and research on the existing microneedle roller, the invention provides the metal sheet of the penetration-promoting pen, which combines knowledge and experience which are mastered by the inventor in the aspects of fine processing technologies such as laser cutting, wire-cut electric discharge machining and the like, so as to solve one of the technical problems in the prior art, and the size, the length of the microneedle with the protruding outer circumferential surface and the distance between the microneedles of the metal sheet can be very small under the condition that the sharp needle tip is ensured, so that the processing efficiency and precision are high, the consistency is good, and the energy-saving and environment-friendly mass production with low cost can be realized.
The invention also provides a roller of the penetration-promoting pen adopting the metal sheet, which has smaller outer dimension, shorter micro-needles, higher array density, high assembly speed, high precision, good consistency, orderly arrangement of the micro-needles and easy cleaning. Therefore, the device is convenient for more uniform and fine operation in the concave-convex area of the face, does not feel painful and is not easy to see blood when the needle is applied, the same area is not required to be repeatedly pressed, and the massage permeation promoting effect can be obviously improved only by rolling once on the skin surface.
The invention also provides a permeation promotion pen adopting the roller with the metal sheet, which has a small and exquisite structure, is attractive, is convenient for operating, protecting and carrying the roller, and has obvious permeation promotion effect and safer effect.
According to the metal sheet of the penetration promoting pen, the embodiment of the first aspect of the invention comprises: the metal sheet is provided with a first mounting hole and a first notch communicated with the first mounting hole and the outer circumferential surface of the metal sheet, the outer circumferential surface of the metal sheet is provided with a plurality of microneedles which are arranged around the circle center of the metal sheet according to a set interval, the free ends of the microneedles are sharp needle points which are easy to pierce into skin, and the metal sheet is manufactured by wire cut electrical discharge machining.
According to one embodiment of the invention, the thickness of the metal sheet is 30-450 micrometers, and a plurality of the microneedles form a row of microneedle arrays arranged around the center of the metal sheet on the outer circumferential surface of the metal sheet according to a set interval.
According to one embodiment of the present invention, the thickness of the metal sheet is 1 to 12 mm, the first notch extends in the direction of the axis of the metal sheet, and the plurality of microneedles are divided into a plurality of rows arranged along the axis of the metal sheet, each row including a plurality of microneedles disposed around the center of the metal sheet to form a microneedle array on the outer circumference of the metal sheet.
According to a second aspect of the invention, a roller for a penetration enhancing pen comprises a plurality of metal sheets with the thickness of 30-450 micrometers.
According to one embodiment of the invention, the roller of the penetration-promoting pen comprises a gasket, a mounting shaft and a sealing strip, wherein the gasket is arranged between two adjacent metal sheets, a second mounting hole is formed in the gasket, and a second notch which is communicated with the second mounting hole and the outer circumferential surface of the gasket is formed in the gasket; the first mounting hole and the second mounting hole are respectively sleeved on the mounting shaft so as to mount the metal sheet and the gasket on the mounting shaft; the sealing strip extends along the axial direction of the mounting shaft and is filled in the first notch and the second notch, and the first notches of the metal sheets and the second notches of the gaskets are matched with the sealing strip.
According to one embodiment of the invention, the sealing strip is configured as a projection provided on the mounting shaft and extending in the axial direction of the mounting shaft, the projection being integrally formed with the mounting shaft.
According to one embodiment of the invention, the length of the microneedles on the metal sheets differs from one sheet to another in the axial direction of the mounting shaft.
According to one embodiment of the present invention, further comprising: one side of the first limiting joint is connected to the first axial end of the mounting shaft so as to limit the freedom degrees of the metal sheet and the gasket towards the first axial end of the mounting shaft; the other side of the first limit joint is provided with a first pin hole or a first pin; one side of the second limiting joint is connected to the second axial end of the mounting shaft so as to limit the freedom degrees of the metal sheet and the gasket towards the second axial end of the mounting shaft; the other side of the second limiting joint is provided with a second pin hole or a second pin.
According to one embodiment of the invention, the first limit joint is integrally formed with the mounting shaft, and the second limit joint is detachable from the mounting shaft.
Another penetration enhancing pen roller according to an embodiment of the second aspect of the present invention comprises a sheet metal of the penetration enhancing pen having a thickness of 1-12 mm.
According to one embodiment of the invention, the roller of the penetration-promoting pen comprises a sealing strip, the sealing strip is filled in the first notch, and the first notch of the metal sheet is matched with the sealing strip.
According to one embodiment of the invention, the roller of the penetration promoting pen comprises a mounting shaft, wherein the first mounting hole is sleeved on the mounting shaft; the sealing strip is configured as a protrusion provided on the mounting shaft, the protrusion being integrally formed with the mounting shaft.
According to an embodiment of the third aspect of the present invention, a penetration enhancing pen further comprises: the pen comprises a pen holder and a pen cap, wherein one end of the pen holder is provided with a bracket, the bracket is used for supporting the roller, and the roller is rotationally limited on the bracket; the pen cap is detachably sleeved at one end of the pen holder where the bracket is located and covers the outside of the bracket and the roller.
According to one embodiment of the present invention, the pen holder is further provided with: LED lamps irradiating towards the roller and the periphery of the roller; and the switch is used for controlling the on-off of the LED lamp.
According to the embodiment of the invention, as the special structure of the first notch with a very narrow width is arranged on the metal sheet of the penetration promoting pen, a series of complicated procedures such as additional punching, threading, positioning and aligning, repeated disassembly and assembly of molybdenum wire or copper wire electrodes and the like are not needed when the traditional numerical control wire cutting equipment is adopted for processing, and continuous and rapid full-automatic batch cutting production of a plurality of metal sheets can be realized. The narrower the first notch, the smaller the microneedle spacing can be. The wire cut electric discharge machine has unique advantages for deep and narrow groove micromachining of various metals, can achieve ultra-high precision and very high surface quality in a micron level, can obtain a mirror surface with roughness Ra=0.1 micron at the highest, and does not generate various burrs such as an oxide layer, convex metal slag and the like on a notch, and does not need additional special surface treatment, so that the wire cut electric discharge machine can be used for preparing metal sheets with small outer diameter size, small microneedle length of the peripheral surface and sharp needle tips, and has high machining precision, high work efficiency, good consistency and more energy conservation and environmental protection in the whole production process.
The roller of the penetration promoting pen manufactured by the metal sheet has smaller outer diameter size, higher density of the microneedle array, shorter needle length, high assembly speed, high precision, good consistency, and orderly arrangement of the microneedles and easy cleaning. Therefore, the device is convenient for more uniform and fine operation in the concave-convex area of the face, and the same area is not required to be repeatedly pressed when the needle is applied, so that the massage permeation promoting effect can be obviously improved by only rolling once on the skin surface. By properly reducing the length of the needle tips on the metal sheets at the two end parts of the roller, all the microneedles on the roller can be more favorably and uniformly penetrated into soft facial skin.
The seepage-promoting pen adopting the roller has the advantages of small and exquisite structure, attractive appearance, convenience in operating, protecting and carrying the roller, remarkable seepage-promoting effect and safer effect. The penetration promoting pen provided with the LED lamp is favorable for observing the states of the needle point on the roller and the skin to be pricked and applied.
Additional aspects and advantages of the invention will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of the invention.
Drawings
The foregoing and/or additional aspects and advantages of the invention will become apparent and may be better understood from the following description of embodiments taken in conjunction with the accompanying drawings in which:
FIG. 1 is a schematic view of a metal sheet according to one embodiment of the present invention;
Fig. 2 is a schematic view of a structure of a metal sheet according to another embodiment of the present invention;
FIGS. 3-6 are schematic structural views of a roller according to various embodiments of the present invention;
FIG. 7 is a schematic view of the structure of a gasket according to one embodiment of the present invention;
FIG. 8 is a schematic structural view of a mounting shaft according to one embodiment of the invention;
FIG. 9 is a schematic view of a spacing tab according to one embodiment of the invention;
FIG. 10 is a schematic view of an integrally formed mounting shaft and spacing joint according to one embodiment of the present invention;
FIG. 11 is a schematic diagram of the structure of a penetration enhancing pen according to one embodiment of the present invention;
fig. 12 is a schematic structural view of a penetration enhancing pen according to another embodiment of the present invention.
Reference numerals:
A penetration promoting pen 100;
a roller 10;
A metal sheet 101; a first mounting hole 1011; a first notch 1012; micropins 1013; a needle tip 10131, an outer circumferential surface 10132 of the metal sheet 101;
a spacer 102; a second mounting hole 1021; a second notch 1022; the outer circumferential surface 1023 of the gasket 102;
a mounting shaft 103; sealing strips or protrusions 1031; a positioning pin 1032;
A first limit joint 104; a first plunger 1041; first pin bore or first pin 1042;
a second limit joint 105; a second plunger 1051; a second pin aperture or second pin 1052;
A barrel 20; a holder 201; a support arm 2011; pin 2012;
A cap 30.
Detailed Description
Embodiments of the present invention are described in detail below, examples of which are illustrated in the accompanying drawings, wherein like or similar reference numerals refer to like or similar elements or elements having like or similar functions throughout. The embodiments described below by referring to the drawings are illustrative only and are not to be construed as limiting the invention.
The sheet metal of the penetration enhancing pen according to an embodiment of the first aspect of the present invention will be described below with reference first to fig. 1 and 2.
Fig. 1 shows a schematic structure of a metal sheet of a penetration enhancing pen according to an embodiment of the present invention, wherein a metal sheet 101 is provided with a first mounting hole 1011 and a first notch 1012 communicating the first mounting hole 1011 with an outer circumferential surface 10132 of the metal sheet 101. The first notch 1012 should generally have a notch width as narrow as possible, the two edges of the sheet metal 101 that make up the notch should generally be substantially parallel to each other, and the extension line of the center line should generally pass through the center axis/center of the circle and be substantially parallel to the two edges of the notch. The metal sheet 101 is substantially annular, and a first mounting hole 1011 is formed in the middle of the metal sheet 101, the center of the first mounting hole 1011 coinciding with the center of the metal sheet 101.
The outer circumferential surface 10132 of the metal sheet 101 is provided with a plurality of micro-needles 1013 arranged around the center of the metal sheet 101 at a set pitch, and the actual positions of the micro-needles 1013 and the mutual pitches thereof can be set as required, and generally, the micro-needles 1013 are uniformly arranged on the outer circumferential surface 10132 of the metal sheet 101 by default. The free ends of the micro-needles 1013 are sharp tips 10131 that easily penetrate the skin, i.e., the very sharp tips 10131 of the micro-needles 1013 can easily penetrate the skin when the sheet metal 101 is rolled over the skin. The metal sheet 101 is manufactured by electric discharge machining.
The present invention is not particularly limited in the aperture of the first mounting hole 1011 of the metal sheet 101, the diameter of the circumference where the outer circumferential surface 10132 is located, the width of the first notch 1012, and the length of the microneedle 1013. If a penetration assisting pen for transdermal administration is manufactured, the first mounting aperture of the metal sheet 101 may be selected to be 0.3 to 5 mm, the diameter of the circumference where the outer circumferential surface 10132 is located is in the range of 2000 to 12000 micrometers, the width of the first notch 1012 is 100 to 1200 micrometers, and the length of the microneedle 1013 is 30 to 600 micrometers; if the penetration promoting pen is used for beauty treatment and skin care, the aperture of the first mounting hole 1011 of the metal sheet 101 may be selected to be 0.5-3 mm, the outer circumferential diameter range is 3000-8000 microns, the width of the first notch 1012 is 250-800 microns, and the length of the micro needle 1013 may be selected to be 50-300 microns. Since the microneedles 1013 are uniformly arranged around the center of the metal sheet 101 on the outer circumferential surface 10132, the narrower the width of the first notch 1012 is, the greater the number of the microneedles 1013 can be arranged and the greater the density of the microneedle array can be.
The metal sheet 101 in the example of the present invention may be made of various metal materials such as stainless steel, titanium or titanium alloy, and processed by a well-known numerical control wire cut electric discharge machine. In the example shown in fig. 1, the metal sheet 101 is manufactured by numerical control electric discharge machining, the thickness of the metal sheet is only 100 micrometers, the outer circumferential surface 10132 of the metal sheet 101 is uniformly distributed with a microneedle array formed by 12 microneedles 1013 protruding outwards and perpendicular to the axial direction, the length of the microneedles 1013 is 300 micrometers, and the free end of the microneedles 1013 has sharp needle tips 10131. The micro-needles 1013 have acute triangular tips in a perpendicular plane to the axis and the micro-needles 1013 have rectangular tips in a coplanar plane to the axis.
According to the embodiment of the invention, the metal sheet 101 for promoting the penetration pen is provided with the first notch 1012 with a very narrow width, so that a series of complicated procedures such as additional punching, threading, positioning alignment, repeated disassembly and assembly of molybdenum wire or copper wire electrodes and the like are not needed when the conventional numerical control wire cutting machine tool is adopted for processing, and continuous and rapid full-automatic batch cutting production of a plurality of metal sheets 101 can be realized. The narrower the first notch 1012, the smaller the spacing between the tips 10131 of the uniformly arranged microneedles 1013 can be. The wire electric discharge machining method has unique advantages for deep and narrow groove micromachining of various metals, can achieve ultra-high precision and very high surface quality in a micron level, can obtain a mirror surface with roughness Ra=0.1 micron at the highest, and does not generate various burrs such as an oxide layer, convex metal slag and the like on a notch, and does not need additional special surface treatment, so that the metal sheet 101 with small diameter, small microneedle length and sharp needle tip distance on the outer circumferential surface 10132 can be prepared by utilizing an electric discharge machining mode, and meanwhile, the machining precision and the working efficiency are high, the consistency is good, and the whole production process is more energy-saving and environment-friendly. Preferably, the wire-cut electric discharge machine is capable of cutting 1000 or more stacked large metal substrates (e.g., each having a thickness of 50-150 μm), so that 1000 or more high quality metal sheets 101 can be simultaneously manufactured at a time by using exactly the same process as cutting one sheet, which cannot be achieved at all by using a laser cutting method or the like. According to the requirements of beauty, biocompatibility and the like, one or more layers of other metal films can be further uniformly covered on the surface of the prepared metal sheet 101 by sputtering, evaporation, electroplating, coating and the like.
The thickness of the metal sheet may be not limited in the present invention. In the case where the metal sheet is relatively thin, as one preferable example, the thickness of the metal sheet 101 in fig. 1 is 30 to 450 μm, and the plurality of micro-needles 1013 form a row of micro-needle arrays uniformly arranged around the center of the metal sheet 101 at a set pitch on the outer circumferential surface 10132 of the metal sheet 101.
That is, in some embodiments of the present invention, the thickness of the metal sheet 101 may be in the range of 30 to 450 micrometers, and thus, the thickness of the metal sheet 101 is thin, so that the number of metal sheets 101 may be selected according to the structure of the roller to which the metal sheet 101 is applied, and thus, the width of the roller 10 (i.e., the axial dimension of the roller 10) may be changed, and the degree of freedom of application is higher. The circumferential spacing between the tips 10131 of two adjacent microneedles 1013 on the sheet metal 101 can be determined according to the circumference of the sheet metal 101, the size (the microneedle length, the sharpness or angle of the tips), the number, etc. of the microneedles 1013, and by adjusting this spacing, the number or density of the microneedles 1013 that can be provided on the sheet metal 101 can be controlled.
In the case where the metal sheet is relatively thick, as shown in fig. 2, it is preferable that the thickness of the metal sheet 101 is 1 to 12 mm, the first notch 1012 of the metal sheet 101 extends in the axial direction, and the plurality of micro-needles 1013 form a row of micro-needle arrays arranged around the axis of the metal sheet 101 in a plurality of rows at a set pitch on the outer circumferential surface 10132 of the metal sheet 101.
That is, in other embodiments of the present invention, the thickness of the metal sheet 101 may range from 1 to 12 mm, the first notch 1012 extends in the direction of the axis of the metal sheet 101, and the plurality of micro-needles 1013 are divided into a plurality of rows arranged along the axis of the metal sheet 101, each row including a plurality of micro-needles 1013 arranged around the center of the metal sheet 101 to form a micro-needle array on the outer circumferential surface 10132 of the metal sheet 101.
Therefore, when the thickness of the metal sheet 101 is thicker, the metal sheet 101 can be used as the main structure of one roller 10, that is, one roller 10 can only comprise one metal sheet 101, so that the metal sheet 101 on the roller forms a seamless structure, the possibility of dirt collection of the roller is reduced, and the roller is cleaner.
In the example shown in fig. 2, the thickness of the metal sheet 101 may be 4 mm, the first notch 1012 of the metal sheet 101 extends in the direction of the axis of the metal sheet 101 (i.e., the thickness direction of the metal sheet 101), and 8 microneedles 1013 having a length of 150 μm are formed in a row on the outer circumferential surface 10132 of the metal sheet 101 to form 7 rows of microneedle arrays disposed around the axis thereof at a set pitch, i.e., the microneedle arrays have 56 microneedles in total. The structure with the multi-row micro-needle array can be manufactured by utilizing a numerical control wire cut electric discharge machine and combining a traditional rotating clamp.
A roller 10 for a penetration assisting pen according to an embodiment of the second aspect of the present invention is described below with reference to fig. 1 to 10.
First, a roller 10 of a first type of penetration assisting pen according to an embodiment of the second aspect of the present invention will be described with reference to fig. 1, 3 to 10. In some embodiments of the present invention, the penetration enhancing pen roller 10 includes a plurality of metal sheets 101 having a thickness of 30-450 microns, such as shown in FIG. 1. Specific embodiments of the roller 10 will be described in detail below.
As shown in fig. 3 to 6, the roller 10 includes a gasket 102, a mounting shaft 103 and a sealing strip 1031 in addition to a plurality of metal sheets 101 having a thickness of 30 to 450 μm as shown in fig. 1. The gasket 102 is disposed between two adjacent metal sheets 101, and the gasket 102 is provided with a second mounting hole 1021 as shown in fig. 7, and the gasket 102 may be a circular gasket, but the gasket 102 is typically provided with a second notch 1022 that communicates the second mounting hole 1021 with the outer circumferential surface 1023 of the gasket 102. The first mounting hole 1011 and the second mounting hole 1021 are respectively sleeved on the mounting shaft 103 to mount the metal sheet 101 and the spacer 102 on the mounting shaft 103. The sealing strip 1031 extends along the axial direction of the mounting shaft 103 and is filled in the first notch 1012 and the second notch 1022, and the first notch 1011 of the plurality of metal sheets 101 and the second notch 1021 of the gasket 102 are both matched with the sealing strip 1031.
By filling the sealing strip 1031 in the first notch 1012 and the second notch 1022, gaps on the metal sheet 101 and the gasket 102 can be blocked, the smoothness of the outside of the roller 10 is ensured, the roller 10 is prevented from being polluted, and the roller 10 is free of gaps and convenient to clean.
As a preferred embodiment, as shown in fig. 8, the sealing strip 1031 is a protrusion 1031 provided on the mounting shaft 103, i.e., the protrusion 1031 is integrally manufactured with the mounting shaft 103. Preferably, the length of the microneedles 1013 on different metal sheets 101 in the axial direction are different.
That is, the sealing strip 1031 is configured as a protrusion provided on the mounting shaft 103 and extending in the axial direction of the mounting shaft 103, the protrusion being integrally formed with the mounting shaft 103. Therefore, the sealing strip 1031 is arranged on the mounting shaft 103, and the sealing strip 1031 is matched in the first notch 1012, so that the metal sheet 101 can be rapidly positioned and mounted on the mounting shaft 103, the micro-needles 1013 on the roller 10 are uniformly and orderly arrayed, the repeatability is good, the surface of the roller 10 is attractive, no dead angle exists, and the cleaning is convenient. That is, the sealing strip 1031 specially provided on the mounting shaft 103 is matched in the first notch 1012 on the metal sheet 101 and is matched in the second notch 1022 of the gasket 102, so that the high speed and high efficiency of batch processing and assembly can be ensured, and therefore, the assembled roller 10 has high precision, good consistency, low cost, uniform and regular surface microneedle arrangement, safe and flexible use, and convenient cleaning and carrying.
As a preferred embodiment, the roller 10 further includes a first limit joint 104 and a second limit joint 105. As shown in fig. 9, a first plunger 1041 is provided on one side of the first limit joint 104, and the first plunger 1041 is connected to the first axial end of the mounting shaft 103, so as to limit the degree of freedom of the metal sheet 101 and the gasket 102 toward the first axial end of the mounting shaft 103, and a first pin hole or a first pin 1042 is provided on the other side of the first limit joint 104.
A second plunger 1051 is provided on one side of the second stopper tab 105, and the second plunger 1051 is connected to the second axial end of the mounting shaft 103 to limit the degree of freedom of the metal sheet 101 and the spacer 102 toward the second axial end of the mounting shaft 103, and a second pin hole or second pin 1052 is provided on the other side of the second stopper tab 105.
As a preferred embodiment, the first limit joint 104 is integrally formed with the mounting shaft 103 as shown in fig. 10, and the second limit joint 105 is detachable from the mounting shaft 103.
The roller 10 in the penetration assisting pen 100 according to various embodiments of the present invention will be described in detail with reference to fig. 3 to 10, respectively.
As shown in fig. 3, the number of metal sheets 101 may be five, and the five metal sheets 101 are sequentially arranged along the axial direction, and a gasket 102 is disposed between two adjacent metal sheets 101. Alternatively, the two metal sheets 101 located at the outermost side in the axial direction may be further provided with a spacer 102 on each outer side. In the case of determining the thickness of the metal sheet 101 and the spacer 102, the width of the roller 10 (i.e. the axial dimension of the roller 10) can be changed by changing the number of the metal sheets 101 and the spacer 102, so that the roller 10 can be suitable for different permeation promotion occasions, for example, the width of the roller 10 for promoting permeation of facial skin can be smaller than the width of the roller 10 for promoting permeation of back.
The metal sheets 101 and the gaskets 102 are coaxially and alternately arranged in a compact manner, and the metal sheets 101 and the gaskets 102 can be fixed on the mounting shaft 103 by an adhesive. In fig. 3, mounting shafts 103 are protruded from both ends of the roller constituted by the metal sheet 101 and the spacer 102 to form positioning pins 1032 so as to be inserted into pin holes to which the penetration enhancing pen is fixed, thereby allowing the roller 10 to rotate. The gasket 102 may be a ring, preferably, the gasket 102 with the second notch 1022 shown in fig. 7 may be used, the first notch 1011 of the plurality of metal sheets 101 and the second notch 1021 of the gasket 102 are matched with the sealing strip 1031 arranged along the axial direction, or the sealing strip 1031, the metal sheets 101, the gasket 102 and the mounting shaft 103 may be fixed together by using an adhesive, so that the roller 10 has no gap, is convenient for cleaning, and the microneedle array is orderly and attractive.
The sealing strip 1031 may be formed by filling and curing an adhesive such as silicone rubber, epoxy resin, etc., or bonding and curing a filler sheet of the same or similar material as the metal sheet, gasket, etc. If the sealing strip 1031 is integrally manufactured with the mounting shaft 103, as shown in fig. 8, the sealing strip 1031 is a protrusion 1031 provided on the mounting shaft 103, and the metal sheet 101 and the gasket 102 can be mounted and positioned by using the protrusion 1031 on the mounting shaft 103, so that not only is the assembly efficiency of the roller 10 improved, but also all components and the micro-needles 1013 can be aligned very conveniently during assembly by positioning the first notch 1012 and the second notch 1022 with the protrusion 1031, and the product is more easy to be tidy, attractive and easy to clean. In the example of the present invention, the width of the first notch 1012 provided on the metal sheet 101 and the width of the second notch 1022 provided on the gasket 102 may be adapted to the width of the protrusion 1031 on the mounting shaft 103, that is, the width of the first notch 1012 and the second notch 1022 may be substantially equal to the width of the protrusion 1031, and the first notch 1012 and the second notch 1022 may be in interference fit, clearance fit, or transition fit with the protrusion 1031. Preferably, the second notch 1022 on the spacer 102 is the same size as the first notch 1012 on the metal sheet 101, and by fixing and aligning the positions of the first notch 1012 and the second notch 1022, all the components and the needle tip can be aligned very conveniently during assembly, and the product is more easily tidy, attractive and easy to clean.
Preferably, the outer surface of the protrusion 1031 is flush with the outer peripheral surface of the pad 102 so that the surface of the roller 10 is more aesthetically pleasing and easy to clean. Alternatively, the outer diameter of the outer circumferential surface 10132 of the metal sheet 101 may be different from the outer diameter of the outer circumferential surface 1023 of the gasket 102, and preferably, the outer circumferential surface 10132 of the metal sheet 101 is flush with the outer circumferential surface 1023 of the gasket 102, that is, the outer diameter of the outer circumferential surface 10132 of the metal sheet 101 is the same as the outer diameter of the outer circumferential surface 1023 of the gasket 102, so that the structure can achieve thorough cleaning without dead angle and is more beautiful.
As shown in fig. 4, in some embodiments of the present invention, the roller 10 further includes a first limit joint 104 and a second limit joint 105, where a first plunger 1041 may be disposed on one side of the first limit joint 104 and fixed on an axial first end of the mounting shaft 103 by way of plugging, so as to limit the degree of freedom of the metal sheet 101 and the gasket 102 toward the first end, and the other side of the first limit joint has a protruding first pin 1042. One side of the second limiting joint 105 may be provided with a second plunger 1051 and fixed to the second axial end of the mounting shaft 103 by means of plugging, so as to limit the degree of freedom of the metal sheet 101 and the gasket 102 in the direction of the second end, and the other side of the second limiting joint is provided with a protruding second plunger 1052. The first and second stopper joints 104 and 105 may have a structure as shown in fig. 9, in which one side is the first plunger 1041 or the second plunger 1051 and the other side is the first pin hole 1042 or the second pin hole 1052. By providing the first limit joint 104 and the second limit joint 105, the metal sheet 101 and the gasket 102 can be fixed on the mounting shaft 103, and the metal sheet 101 or the gasket 102 can be prevented from falling from the axial direction, so that the roller 10 is self-integrated, and the structure is stable and compact. And this is more convenient when the roller 10 is mounted to other structures.
In the embodiment shown in fig. 5 and 6, the first limit joint 104 is integrally formed with the mounting shaft 103, and the second limit joint 105 is detachable from the mounting shaft 103. This will further improve the efficiency and reduce the cost. And further to fig. 10, there is shown a structure in which the first spacing tab 104 is integrally formed with the mounting shaft 103 provided with the protrusion 1031. In the embodiment shown in fig. 5 and 6, it can be seen that the roller 10 has five metal sheets 101 and four gaskets 102, the left side of the roller 10 is provided with a first limiting joint 104, the first limiting joint 104 and the mounting shaft 103 are integral and not detachable, when assembling, the five metal sheets 101 and the four gaskets 102 are coaxially and alternately arranged on the mounting shaft 103 provided with the first limiting joint 104, and then a separate second limiting joint 105 is inserted and fixed to the other end of the mounting shaft 103 through a second plunger 1051, so as to complete the assembly of the roller 10. The structure can complete assembly and positioning without arranging adhesives, and can obviously improve the assembly efficiency and reduce the manufacturing cost.
Of course, the present invention is not limited thereto, and the first limit connector 104 and the second limit connector 105 may be provided with mating grooves, and the corresponding ends of the mounting shaft 103 may be provided with plungers, thereby also completing the mounting and mating of the first limit connector 104 and the second limit connector 105 on the mounting shaft 103.
Alternatively, both ends of the mounting shaft 103 may be provided with a fitting groove or a plunger, or one of both ends of the mounting shaft 103 may be provided with a fitting groove, and the other end may be provided with a plunger. Or alternatively, the mounting shaft 103 may be a hollow structure, that is, the mounting shaft 103 is provided with a shaft hole penetrating through the axial length thereof, so that the weight of the product can be reduced and the cost can be reduced on the premise of meeting the requirement of mounting.
In some embodiments of the present invention, the plurality of metal sheets 101 mounted on one roller 10 may be identical. In other examples of the invention, the length of the microneedles 1013 on different metal sheets 101 on the roller 10 may be different in the axial direction. For example, in the specific example shown in fig. 6, the length of the micro-needles 1013 on the metal sheet 101 located in the middle of the roller 10 is longer than the length of the micro-needles 1013 on the metal sheet 101 located on both sides in the axial direction of the roller 10. Therefore, when the roller 10 is applied to a soft cheek portion, the problem that the needle tips 10131 of the micro-needles 1013 positioned in the middle area of the roller 10 are difficult to fully penetrate into the skin can be avoided, so that the roller 10 is more uniform in penetrating into the skin, the problem of skin damage caused by repeatedly rolling the skin at the same place can be avoided, and the roller is safer and more convenient to use.
In alternative embodiments of the present invention, the spacer 102 and the mounting shaft 103 may be made of various metals, plastics, ceramics, rubber, glass, wood, composite materials, etc., and mass-produced by cutting, injection molding, stamping, etc. The thickness of the spacer 102 may be selected to be 100 to 2000 microns, and further may be set to be 200 to 900 microns, as desired, and in some embodiments of the present invention, the thickness of the spacer 102 ranges from 400 to 700 microns. Optionally, the gasket 102 has the same or similar inner and outer diameters as the metal sheet 101, and will not be described in detail herein.
A roller 10 of a second type of penetration enhancing pen in accordance with an embodiment of the second aspect of the present invention is described below with reference to fig. 2, 3-10. Unlike the first roller 10 formed using the metal sheet 101 as described in fig. 1, in the second roller 10, the roller 10 is formed using the metal sheet 101 having a thickness of 1 to 12 mm as shown in fig. 2, for example.
When the sheet metal 101 reaches a thickness of 1 to 12 mm, as shown in fig. 2, in some examples of the present invention, it may be mounted as a roller 10 directly on a short shaft of a fixed bracket (e.g., a stud 2012 in fig. 11 and 12) so as to be rotatable. In other examples of rollers, the first and second stopper tabs 104, 105 may be directly fixed to both ends of the metal sheet 101 as shown in fig. 2 to form the roller 10, and then the metal sheet 101 with the first and second stopper tabs 104, 105 mounted thereon is mounted on a short shaft (e.g., the pins 2012 in fig. 11 and 12) of the fixing bracket.
As a preferred embodiment, the first mounting hole 1011 of the metal sheet 101 is sleeved on the mounting shaft 103, and the sealing strip 1031 is filled in the first notch 1012, so that the first notch 1012 of the metal sheet 101 is mounted in cooperation with the sealing strip 1031. Further, an adhesive may be used to secure the sealing strip 1031 and the metal sheet to the mounting shaft 103. As a preferred embodiment, the sealing strip 1031 is a protrusion on the mounting shaft 103, i.e. the protrusion is made integrally with the mounting shaft 103.
Other technical features of the roller 10 formed by using the metal sheet 101 shown in fig. 2 may be the same as those of the roller 10 formed by using the metal sheet 101 shown in fig. 1, and will not be described in detail herein.
The roller 10 formed by using the metal sheet 101 shown in fig. 2 has no assembling process for a plurality of metal sheets and gaskets, can be more compact and small in structure, and has no dead angle such as a gap, which is difficult to clean.
A penetration assisting pen 100 according to an embodiment of the third aspect of the present invention is described below with reference to fig. 11 to 12.
Referring to fig. 11 to 12, which are schematic structural views of a penetration enhancer 100 according to an embodiment of the present invention, the penetration enhancer 100 further includes, in addition to the roller 10: a barrel 20 and a cap 30. One end of the pen holder 20 is provided with a bracket 201, the bracket 201 is used for supporting the roller 10, and the roller 10 is rotatably limited on the bracket 201; the cap 30 can be detachably sleeved at one end of the holder 201 of the pen holder 20 to protect the holder 201 and the roller 10 from damage, that is, the cap 30 is detachably sleeved at one end of the holder 201 of the pen holder 20 and covers the outside of the holder 201 and the roller 10.
From the external view, the penetration promoting pen 100 according to the embodiment of the present invention can be generally shaped like a pen-like structure such as a sign pen with an elongated pen holder or a laser pen with a battery, and the pen holder has one end with a straight or curved rod-like structure such as a round or flat shape for easy hand-holding operation. As shown in fig. 11, the pen holder 20 according to the embodiment of the present invention may be cylindrical, one end of the pen holder 20 is provided with a bracket 201, the bracket 201 includes two left and right support arms 2011, opposite sides of the two support arms 2011 are respectively provided with a pin 2012, and the roller 10 is rotatably limited between the two pins 2012. Alternatively, the two ends of the mounting shaft 103 may be provided with mating grooves (the mating grooves may be through holes penetrating the axial length of the mounting shaft 103, and the mating grooves may be non-through holes), and the pins 2012 on the bracket 201 extend into the mating grooves at the two ends of the mounting shaft 103, respectively, so as to complete the installation of the roller 10.
As shown in fig. 12, the barrel 20 according to the embodiment of the present invention may have a substantially conical shape with one large end and the other small end, but the present invention is not limited thereto, and the barrel 20 may be formed in various shapes for easy holding and may have various solid or hollow handle structures for easy holding operation. The free end of the roller first limit joint 104 in fig. 12 is provided with a first pin hole 1042, the free end of the second limit joint 105 is provided with a second pin hole 1052, and two pins 2012 on the bracket 201 respectively extend into the first pin hole 1042 and the second pin hole 1052, thereby completing the installation of the roller 10. On the contrary, two opposite sides of the two support arms 2011 may be respectively provided with a matching groove, and the free ends of the first limiting connector 104 and the second limiting connector 105 are respectively provided with pins, so that the roller 10 can be installed.
Preferably, the pen holder can be further provided with an LED lamp facing the roller 10 and irradiating around the roller, and a switch for controlling the on/off of the LED lamp. Alternatively, a hollow barrel 20 may be used, in which a battery may be mounted, a switch is provided on the surface of the barrel 20, and an LED may be provided between the two support arms.
The pen holder 20 and the pen cap 30 can be made of metal, plastic, rubber, glass, ceramic, wood, composite materials and the like, and can be manufactured in batches by adopting mature processes and methods such as stamping, injection molding, vapor deposition and the like.
After the penetration enhancer pen 100 is encapsulated, sterilization can be performed in a conventional high-pressure steam sterilization, ethylene oxide sterilization or irradiation sterilization mode, and the like, so that the penetration enhancer pen can be used as a sterile instrument for safety during the effective period.
In the description of the present specification, reference to the terms "one embodiment," "some embodiments," "illustrative embodiments," "examples," "specific examples," or "some examples," etc., means that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, schematic representations of the above terms do not necessarily refer to the same embodiments or examples. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
While embodiments of the present invention have been shown and described, it will be understood by those of ordinary skill in the art that: many changes, modifications, substitutions and variations may be made to the embodiments without departing from the spirit and principles of the invention, the scope of which is defined by the claims and their equivalents.
Claims (11)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811303499.8A CN109350842B (en) | 2018-11-02 | 2018-11-02 | Roller of penetration-promoting pen and metal sheet thereof, penetration-promoting pen |
| PCT/CN2019/113385 WO2020088371A1 (en) | 2018-11-02 | 2019-10-25 | Metal sheet of permeation promotion pen, and roller and permeation promotion pen having metal sheet |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811303499.8A CN109350842B (en) | 2018-11-02 | 2018-11-02 | Roller of penetration-promoting pen and metal sheet thereof, penetration-promoting pen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109350842A CN109350842A (en) | 2019-02-19 |
| CN109350842B true CN109350842B (en) | 2024-11-26 |
Family
ID=65344147
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811303499.8A Active CN109350842B (en) | 2018-11-02 | 2018-11-02 | Roller of penetration-promoting pen and metal sheet thereof, penetration-promoting pen |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109350842B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020088371A1 (en) * | 2018-11-02 | 2020-05-07 | 清华大学 | Metal sheet of permeation promotion pen, and roller and permeation promotion pen having metal sheet |
| CN110076528A (en) * | 2019-05-13 | 2019-08-02 | 大连理工大学 | A kind of planar metal microneedle array and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103263727A (en) * | 2013-05-22 | 2013-08-28 | 清华大学 | Metal microneedle array, percutaneous medicine feeding paster, Dermaroller and microneedle electrode array |
| CN203436688U (en) * | 2013-05-22 | 2014-02-19 | 清华大学 | Metal microneedle array, transdermal delivery patch, microneedle delivery stamp, microneedle cosmetology stamp, microneedle roller and microneedle electrode array |
| KR20140044098A (en) * | 2012-10-04 | 2014-04-14 | 공광열 | Microneedle roller |
| CN209548521U (en) * | 2018-11-02 | 2019-10-29 | 清华大学 | The roller of the penetration-promoting pen and its metal sheet, and the penetration-promoting pen |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101085484A (en) * | 2006-06-07 | 2007-12-12 | 山东泰工工贸有限责任公司 | Molybdenum wire guide for electric spark wire cutting machine |
| KR100908893B1 (en) * | 2007-12-07 | 2009-07-22 | 이명인 | Disc needle roller |
| EP2905047A1 (en) * | 2014-02-10 | 2015-08-12 | LTS LOHMANN Therapie-Systeme AG | Micro-needle system and method for producing the same |
| CN207592976U (en) * | 2017-12-19 | 2018-07-10 | 广汉鸿达硬质合金有限责任公司 | A kind wire cutting is evenly distributed with the fixture of notch |
| CN108325063B (en) * | 2017-12-22 | 2023-12-15 | 广州析芒医疗科技有限公司 | Device with electric stimulation micro needle point array structure |
-
2018
- 2018-11-02 CN CN201811303499.8A patent/CN109350842B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20140044098A (en) * | 2012-10-04 | 2014-04-14 | 공광열 | Microneedle roller |
| CN103263727A (en) * | 2013-05-22 | 2013-08-28 | 清华大学 | Metal microneedle array, percutaneous medicine feeding paster, Dermaroller and microneedle electrode array |
| CN203436688U (en) * | 2013-05-22 | 2014-02-19 | 清华大学 | Metal microneedle array, transdermal delivery patch, microneedle delivery stamp, microneedle cosmetology stamp, microneedle roller and microneedle electrode array |
| CN209548521U (en) * | 2018-11-02 | 2019-10-29 | 清华大学 | The roller of the penetration-promoting pen and its metal sheet, and the penetration-promoting pen |
Also Published As
| Publication number | Publication date |
|---|---|
| CN109350842A (en) | 2019-02-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103263727B (en) | Metal micro-needle array, percutaneous dosing paster, micropin roller and microneedle electrodes array | |
| CN101829396B (en) | Microneedle array chip, transdermal drug delivery patch using same and preparation method thereof | |
| CN103203072B (en) | Metal micro-needle array flexible patch, transdermal applicator and transdermal application patch | |
| CN203436688U (en) | Metal microneedle array, transdermal delivery patch, microneedle delivery stamp, microneedle cosmetology stamp, microneedle roller and microneedle electrode array | |
| WO2009130926A1 (en) | Endermic method, needle organizer and endermic injector device | |
| US10799691B2 (en) | Needle assembly for transdermal administration and method of producing the same | |
| KR100908893B1 (en) | Disc needle roller | |
| CN109350842B (en) | Roller of penetration-promoting pen and metal sheet thereof, penetration-promoting pen | |
| JP2004065775A (en) | Device equipped with needle-like structure element | |
| JPWO2016114213A1 (en) | Transdermal administration device | |
| CN112516451B (en) | Capillary hollow metal microneedle, array chip and application thereof | |
| US20200230389A1 (en) | Micropenetrator device for penetrating a biological barrier | |
| JP7383913B2 (en) | microneedle device | |
| CN209548521U (en) | The roller of the penetration-promoting pen and its metal sheet, and the penetration-promoting pen | |
| CN100544790C (en) | Acoustic Needle Insertion System for Microneedle Array Patch | |
| WO2020088371A1 (en) | Metal sheet of permeation promotion pen, and roller and permeation promotion pen having metal sheet | |
| CN219662640U (en) | Metal microneedle array flexible patch and transdermal drug delivery patch | |
| JP7459459B2 (en) | micro needle | |
| CN211357416U (en) | Metal micro-needle penetration-promoting stamp | |
| CN115382084A (en) | Microneedle patch pushing device | |
| JP2018529459A (en) | Massage and beauty care equipment | |
| CN215018670U (en) | Novel skin is dosed device | |
| CN216676701U (en) | Electrode plate with microneedle structure | |
| CN215084208U (en) | Microneedle patch pushing device | |
| CN215386062U (en) | Anti-allergic metal mask |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |