CN109331224A - A kind of gel and its preparation method and application - Google Patents
A kind of gel and its preparation method and application Download PDFInfo
- Publication number
- CN109331224A CN109331224A CN201811112895.2A CN201811112895A CN109331224A CN 109331224 A CN109331224 A CN 109331224A CN 201811112895 A CN201811112895 A CN 201811112895A CN 109331224 A CN109331224 A CN 109331224A
- Authority
- CN
- China
- Prior art keywords
- gel
- parts
- hyaluronic acid
- weight
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 29
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 51
- 229920002674 hyaluronan Polymers 0.000 claims abstract description 51
- 229960003160 hyaluronic acid Drugs 0.000 claims abstract description 51
- JVTAAEKCZFNVCJ-REOHCLBHSA-N L-lactic acid Chemical compound C[C@H](O)C(O)=O JVTAAEKCZFNVCJ-REOHCLBHSA-N 0.000 claims abstract description 40
- 239000002202 Polyethylene glycol Substances 0.000 claims abstract description 21
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract description 21
- BJRNKVDFDLYUGJ-RMPHRYRLSA-N hydroquinone O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-RMPHRYRLSA-N 0.000 claims description 26
- 239000000284 extract Substances 0.000 claims description 24
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 claims description 18
- 229960004194 lidocaine Drugs 0.000 claims description 18
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 16
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 16
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 16
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- 229960000271 arbutin Drugs 0.000 claims description 13
- BJRNKVDFDLYUGJ-UHFFFAOYSA-N p-hydroxyphenyl beta-D-alloside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(O)C=C1 BJRNKVDFDLYUGJ-UHFFFAOYSA-N 0.000 claims description 13
- OARRHUQTFTUEOS-UHFFFAOYSA-N safranin Chemical compound [Cl-].C=12C=C(N)C(C)=CC2=NC2=CC(C)=C(N)C=C2[N+]=1C1=CC=CC=C1 OARRHUQTFTUEOS-UHFFFAOYSA-N 0.000 claims description 13
- 239000003431 cross linking reagent Substances 0.000 claims description 12
- WERYXYBDKMZEQL-UHFFFAOYSA-N butane-1,4-diol Chemical group OCCCCO WERYXYBDKMZEQL-UHFFFAOYSA-N 0.000 claims description 10
- 239000000419 plant extract Substances 0.000 claims description 8
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 6
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 6
- 239000003963 antioxidant agent Substances 0.000 claims description 6
- 230000003078 antioxidant effect Effects 0.000 claims description 6
- 235000006708 antioxidants Nutrition 0.000 claims description 6
- 230000003796 beauty Effects 0.000 claims description 5
- 239000002253 acid Substances 0.000 claims description 4
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 3
- 244000248825 Peltandra virginica Species 0.000 claims description 3
- 235000001188 Peltandra virginica Nutrition 0.000 claims description 3
- 235000008599 Poria cocos Nutrition 0.000 claims description 3
- 102000019197 Superoxide Dismutase Human genes 0.000 claims description 3
- 108010012715 Superoxide dismutase Proteins 0.000 claims description 3
- 229930003268 Vitamin C Natural products 0.000 claims description 3
- 229930003427 Vitamin E Natural products 0.000 claims description 3
- 238000000605 extraction Methods 0.000 claims description 3
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 3
- 235000019154 vitamin C Nutrition 0.000 claims description 3
- 239000011718 vitamin C Substances 0.000 claims description 3
- 235000019165 vitamin E Nutrition 0.000 claims description 3
- 229940046009 vitamin E Drugs 0.000 claims description 3
- 239000011709 vitamin E Substances 0.000 claims description 3
- HSRJKNPTNIJEKV-UHFFFAOYSA-N Guaifenesin Chemical compound COC1=CC=CC=C1OCC(O)CO HSRJKNPTNIJEKV-UHFFFAOYSA-N 0.000 claims description 2
- IBVAQQYNSHJXBV-UHFFFAOYSA-N adipic acid dihydrazide Chemical compound NNC(=O)CCCCC(=O)NN IBVAQQYNSHJXBV-UHFFFAOYSA-N 0.000 claims description 2
- 239000000499 gel Substances 0.000 abstract description 63
- 230000000694 effects Effects 0.000 abstract description 17
- 230000037303 wrinkles Effects 0.000 abstract description 9
- 230000014759 maintenance of location Effects 0.000 abstract description 7
- 230000000638 stimulation Effects 0.000 abstract description 6
- 239000003814 drug Substances 0.000 abstract description 4
- 230000000052 comparative effect Effects 0.000 description 16
- 239000000463 material Substances 0.000 description 8
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- 241000700159 Rattus Species 0.000 description 5
- 229920002521 macromolecule Polymers 0.000 description 5
- 238000011049 filling Methods 0.000 description 4
- 238000001727 in vivo Methods 0.000 description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
- 229920000747 poly(lactic acid) Polymers 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 102000008186 Collagen Human genes 0.000 description 3
- 108010035532 Collagen Proteins 0.000 description 3
- CTKINSOISVBQLD-UHFFFAOYSA-N Glycidol Chemical compound OCC1CO1 CTKINSOISVBQLD-UHFFFAOYSA-N 0.000 description 3
- 230000032683 aging Effects 0.000 description 3
- 229920001436 collagen Polymers 0.000 description 3
- 235000019441 ethanol Nutrition 0.000 description 3
- 230000003020 moisturizing effect Effects 0.000 description 3
- 239000004626 polylactic acid Substances 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 238000005253 cladding Methods 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 239000000945 filler Substances 0.000 description 2
- 239000003292 glue Substances 0.000 description 2
- 239000004310 lactic acid Substances 0.000 description 2
- 235000014655 lactic acid Nutrition 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 244000061520 Angelica archangelica Species 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 235000001287 Guettarda speciosa Nutrition 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000021164 cell adhesion Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 239000000469 ethanolic extract Substances 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 229930182830 galactose Natural products 0.000 description 1
- 238000001879 gelation Methods 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 206010020718 hyperplasia Diseases 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 230000007102 metabolic function Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 235000015816 nutrient absorption Nutrition 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000003961 penetration enhancing agent Substances 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- -1 polysaccharides compound Chemical class 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000007634 remodeling Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000009759 skin aging Effects 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/34—Materials or treatment for tissue regeneration for soft tissue reconstruction
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Botany (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
Abstract
The present invention relates to a kind of gels and its preparation method and application, belong to field of medicaments.Gel of the invention, comprises the following components in parts by weight: 1~25 part of l-lactic acid, 2~35 parts of hyaluronic acid, 1~25 part of polyethylene glycol.The present invention uses l-lactic acid, hyaluronic acid and the polyethylene glycol of specific components, and gel stability obtained is high, has no stimulation of the skin, and local retention time is long, plasticity is good, the effect that smoothes away wrinkles is obvious.
Description
Technical field
The present invention relates to a kind of gels and its preparation method and application, belong to field of medicaments.
Background technique
In recent years doctor U.S.A quickly grow, wherein artificial chemistry synthesis high molecular material compared with the material of animal origin,
Due to reducing the risk of infectious disease, use is safe, becomes larger its use scope, in order to meet medical cosmetology at this stage
Growth requirement, urgent need invent it is a kind of there is good form and effect, and can be degraded completely by human body and nontoxic macromolecule
Polymeric material.
Polylactic acid (polylactide, PLA) and its copolymer are a kind of macromolecule polymeric materials, have good biology
Compatibility and biodegradability, all products are nontoxic, not will cause vitals aggregation.By U.S.'s food and medicine
Management board (FDA) approves the beautifying use of PLA preparation, for improving the wrinkles such as decree line (laugh line).But it is existing poly-
Lactic product has hydrophobicity, is unfavorable for protein adsorption, and then influence cell adhesion, and be prone to gather in clinical manipulation
The sedimentation of lactic acid particles requires operation skill high.Over time, the intracorporal oxyradical of people gradually increases, and makes skin
Metabolic function is impaired, collagen synthesis is reduced, and wrinkle occurs again, thus the macromolecule of long-time prophylactic treatment skin aging
Polymeric material is urgently studied.
Application No. is 200810009190.8 patents to disclose a kind of macromolecule polymeric material containing macromolecule hydrogel
Hyaluronic acid or the suspension of its salt and preparation method thereof, but its macromolecular is the cross-linked polysaccharides compound or poly- of one-component
Object is closed, therapeutic effect is unobvious, and hyaluronic acid is easy diffusion in vivo and is degraded by the enzyme in injected organism tissue, retention time
It is short, the effect of long-term beauty cannot be played.Application No. is 200810009193.1 patents to disclose a kind of high molecular polymerization material
Material mixed gel and preparation method thereof, preparation process technique is cumbersome, and retention time is short in vivo, cannot play long-term beauty
Effect.
Summary of the invention
It is high that a kind of stability is provided it is an object of the invention to overcome in place of above-mentioned the deficiencies in the prior art, to skin without
Stimulation, local retention time is long, plasticity is good, apparent gel of the effect that smoothes away wrinkles and its preparation method and application.
To achieve the above object, the technical scheme adopted by the invention is as follows: a kind of gel comprises the following components in parts by weight:
1~25 part of l-lactic acid, 2~35 parts of hyaluronic acid, 1~25 part of polyethylene glycol.
By after smearing skin, energy stimulation collagen hyperplasia activates skin, effectively progressively smooths wrinkle l-lactic acid
Line realizes the remodeling of skin profile, and using preceding without carrying out skin allergy treatment, in vivo good biocompatibility, degradation
After may participate in intracorporal metabolism, the problem of without accumulation in vivo.Hyaluronic acid has special water retention, is to have now been found that
Nature in the best substance of moisture retention, referred to as ideal natural moisturizing factor (Natural moisturizing
Factor, NMF, such as: 2% pure hyaluronic acid aqueous solution can firmly hold 98% moisture), human skin maturation and aging
Process also with hyaluronic acid content and metabolism and change, it can improve skin-nourishing and be metabolized, and make that skin is tender, light
It slides, goes wrinkle, increase elasticity, prevent aging, be good skin penetration enhancer again while moisturizing, with other nutritional ingredients
It is used cooperatively, the more preferable effect for promoting nutrient absorption can be played.Polyethylene glycol is in cosmetics industry and pharmaceuticals industry
Using very extensively, having many excellent properties: water solubility, fixedness, physiological inertia, mildness, lubricity and making skin
Sense etc. after soaking, is soft, thering is happiness to use.The present invention uses l-lactic acid, hyaluronic acid and the polyethylene glycol of specific components, system
Gel stability it is high, have no stimulation of the skin, local retention time is long, plasticity is good, the effect that smoothes away wrinkles is obvious.
As the preferred embodiment of gel of the present invention, the gel is comprised the following components in parts by weight: left-handed poly-
15 parts of lactic acid, 20 parts of hyaluronic acid, 20 parts of polyethylene glycol.
As the preferred embodiment of gel of the present invention, the gel further includes the component of following parts by weight: carboxylic first
1~10 part of base cellulose, 1~5 part of plant extracts, 1~10 part of antioxidant, 1~5 part of lidocaine.
As the preferred embodiment of gel of the present invention, the gel further includes the component of following parts by weight: carboxylic first
5 parts of base cellulose, 3 parts of plant extracts, 5 parts of antioxidant, 3 parts of lidocaine.
As the preferred embodiment of gel of the present invention, the antioxidant is arbutin, vitamin C, vitamin
E, at least one of superoxide dismutase.
As the preferred embodiment of gel of the present invention, the plant extracts is safranine flower extract, Radix Angelicae Sinensis mentions
Take at least one of object, tuckahoe extracts, camomile extract, Rhizoma Atractylodis Macrocephalae extract.
Second aspect, the present invention provides the preparation methods of above-mentioned gel, comprising the following steps:
(1) hyaluronic acid gel is made in hyaluronic acid；
(2) other components in addition to hyaluronic acid are mixed according to the ratio and is dissolved in hyaluronic acid water-setting made from step (1)
In glue, gel is obtained.
The preferred embodiment of preparation method as gel of the present invention, in the step (1), hyaluronic acid water-setting
Glue is after hyaluronic acid is dissolved in water, crosslinking agent to be added, is swollen to it.
The preferred embodiment of preparation method as gel of the present invention, in the step (1), the dosage of water is
10 times of bright matter acid weight, the dosage of crosslinking agent are 0.05 times of hyaluronic acid weight, and the crosslinking agent is 1,4-butanediol contracting
At least one of water glycerin ether, adipic dihydrazide.
The third aspect, the present invention provides above-mentioned gel in preparation for the application in the gel of beauty or medical application.
Compared with prior art, the invention has the benefit that the present invention using specific components l-lactic acid, transparent
Matter acid and polyethylene glycol, gel stability obtained is high, has no stimulation of the skin, local retention time is long, plasticity is good,
The effect that smoothes away wrinkles is obvious.
Specific embodiment
Purposes, technical schemes and advantages in order to better illustrate the present invention, below in conjunction with specific embodiment to the present invention
It is described further.
Extracting the preparation method comprises the following steps: 10 times of water is added in plant to it for plant extracts of the present invention, is extracted
90-95 DEG C of temperature, extraction time be 4 times, water extract is obtained after concentrate drying；Ethyl alcohol is added in plant after extraction,
Make alcohol content reach 90wt% or more to extract, ethanol extract is obtained after concentrate drying, water extract and ethyl alcohol are extracted
Object merges to get plant extracts.
Embodiment 1
A kind of gel, contains the following parts by weight: 15 parts of l-lactic acid, 20 parts of hyaluronic acid, polyethylene glycol 20
Part, 5 parts of carboxymethyl cellulose, 3 parts of safranine flower extract, 5 parts of arbutin, 3 parts of lidocaine.
Gel described in the present embodiment the preparation method comprises the following steps:
(1) after hyaluronic acid being dissolved in water, 1,4-butanediol glycidol ether is added as crosslinking agent, is swollen to it
Hyaluronic acid gel, the dosage of water are 10 times of hyaluronic acid weight, and the dosage of crosslinking agent is the 0.05 of hyaluronic acid weight
Times；
(2) l-lactic acid, polyethylene glycol, carboxymethyl cellulose, safranine flower extract, arbutin, lidocaine are pressed
Proportion is mixed and is dissolved in hyaluronic acid gel made from step (1), obtains gel.
Embodiment 2
A kind of gel, contains the following parts by weight: 1 part of l-lactic acid, 35 parts of hyaluronic acid, 1 part of polyethylene glycol,
1 part of carboxymethyl cellulose, 1 part of safranine flower extract, 1 part of arbutin, 1 part of lidocaine.
The preparation method is the same as that of Example 1 for gel described in the present embodiment.
Embodiment 3
A kind of gel, contains the following parts by weight: 25 parts of l-lactic acid, 2 parts of hyaluronic acid, polyethylene glycol 25
Part, 10 parts of carboxymethyl cellulose, 5 parts of safranine flower extract, 10 parts of arbutin, 5 parts of lidocaine.
The preparation method is the same as that of Example 1 for gel described in the present embodiment.
Embodiment 4
A kind of gel, contains the following parts by weight: 10 parts of l-lactic acid, 20 parts of hyaluronic acid, polyethylene glycol 15
Part, 7 parts of carboxymethyl cellulose, 2 parts of safranine flower extract, 4 parts of arbutin, 2 parts of lidocaine.
The preparation method is the same as that of Example 1 for gel described in the present embodiment.
Embodiment 5
A kind of gel, contains the following parts by weight: 15 parts of l-lactic acid, 20 parts of hyaluronic acid, polyethylene glycol 20
Part, 5 parts of carboxymethyl cellulose, 3 parts of angelica extract, 5 parts of vitamin C, 3 parts of lidocaine.
The preparation method is the same as that of Example 1 for gel described in the present embodiment.
Embodiment 6
A kind of gel, contains the following parts by weight: 15 parts of l-lactic acid, 20 parts of hyaluronic acid, polyethylene glycol 20
Part, 5 parts of carboxymethyl cellulose, 3 parts of tuckahoe extracts, 5 parts of vitamin E, 3 parts of lidocaine.
The preparation method is the same as that of Example 1 for gel described in the present embodiment.
Embodiment 7
A kind of gel, contains the following parts by weight: 15 parts of l-lactic acid, 20 parts of hyaluronic acid, polyethylene glycol 20
Part, 5 parts of carboxymethyl cellulose, 3 parts of camomile extract, 5 parts of superoxide dismutase, 3 parts of lidocaine.
The preparation method is the same as that of Example 1 for gel described in the present embodiment.
Comparative example 1
A kind of gel, contains the following parts by weight: 20 parts of hyaluronic acid, 20 parts of polyethylene glycol, carboxymethyl cellulose 5
Part, 3 parts of safranine flower extract, 5 parts of arbutin, 3 parts of lidocaine.
Gel described in the present embodiment the preparation method comprises the following steps:
(1) after hyaluronic acid being dissolved in water, 1,4-butanediol glycidol ether is added as crosslinking agent, is swollen to it
Hyaluronic acid gel, the dosage of water are 10 times of hyaluronic acid weight, and the dosage of crosslinking agent is the 0.05 of hyaluronic acid weight
Times；
(2) polyethylene glycol, carboxymethyl cellulose, safranine flower extract, arbutin, lidocaine are mixed and molten according to the ratio
In the hyaluronic acid gel made from step (1), gel is obtained.
Comparative example 2
A kind of gel, contains the following parts by weight: 15 parts of l-lactic acid, 20 parts of hyaluronic acid, carboxymethyl cellulose
Plain 5 parts, 3 parts of safranine flower extract, 5 parts of arbutin, 3 parts of lidocaine.
Gel described in the present embodiment the preparation method comprises the following steps:
(1) after hyaluronic acid being dissolved in water, 1,4-butanediol glycidol ether is added as crosslinking agent, is swollen to it
Hyaluronic acid gel, the dosage of water are 10 times of hyaluronic acid weight, and the dosage of crosslinking agent is the 0.05 of hyaluronic acid weight
Times；
(2) l-lactic acid, carboxymethyl cellulose, safranine flower extract, arbutin, lidocaine are mixed simultaneously according to the ratio
It is dissolved in hyaluronic acid gel made from step (1), obtains gel.
Comparative example 3
A kind of gel, contains the following parts by weight: 30 parts of l-lactic acid, 1 part of hyaluronic acid, polyethylene glycol 20
Part, 5 parts of carboxymethyl cellulose, 3 parts of safranine flower extract, 5 parts of arbutin, 3 parts of lidocaine.
The preparation method is the same as that of Example 1 for gel described in the present embodiment.
Comparative example 4
A kind of gel, contains the following parts by weight: 15 parts of l-lactic acid, 40 parts of hyaluronic acid, polyethylene glycol 30
Part, 5 parts of carboxymethyl cellulose, 3 parts of safranine flower extract, 5 parts of arbutin, 3 parts of lidocaine.
The preparation method is the same as that of Example 1 for gel described in the present embodiment.
Effect example 1
The thrust test of the embodiment of the present invention 1~7 and comparative example 1~4
Under the pressure of 15~50N, gel obtained by Examples 1 to 7 can be easier to release, and comparative example 1~2 uses 27G
Syringe needle is not easy to release, and comparative example 3~4 is not pushed away with 27G syringe needle and flowed out.As it can be seen that gel prepared by the present invention is suitable for smearing,
It is also applied for injection.
Effect example 2
The stability test of the embodiment of the present invention 1~7 and comparative example 1~4
Examples 1 to 7 and the resulting gel of comparative example 1~4 are placed in 4 DEG C of refrigerator to save after a week, taking-up is same to set 35 DEG C
~40 DEG C of heat preservation 10min, Examples 1 to 7 gained gel are uniform suspension, and it is significant heavy to occur in comparative example 1~2
Drop has apparent separation of solid and liquid phenomenon, and comparative example 3~4 has a small amount of floccule to generate, viscosity decline.As it can be seen that prepared by the present invention
Gel is with good stability.
Effect example 3
The clinical application of the embodiment of the present invention 1~7 and comparative example 1~4 is tested
It selects 220 healthy rats as subjects, D- is smeared with the amount of 125mg/kg.d at the back of every rat
Galactose solution, it is continuous to smear 40 days, rat aging model is obtained, 11 groups is then divided it in average into, every group 20, applies respectively
Examples 1 to 7 and the resulting gel of comparative example 1~4 are smeared, smearing dosage is 1ml/kg, every component after smearing 60 days and 180 days
Dead 10 of other places, anatomic observation smear position, and the results are shown in Table 1.
Table 1
As can be seen from Table 1, dissect rat after 60 days, by histological observation, the smearing position of Examples 1 to 7 by compared with
More collagenous fibres claddings, plays preferable filling effect, the smearing position filler of comparative example 1~4 is by a small amount of collagen
Fiber cladding, filling effect are poor；Rat is dissected after 180 days, by histological observation, Examples 1 to 7 smears the true of position
Skin thickness obviously increases, and smears position and coated by a large amount of collagenous fibres, plays permanent filling effect, comparative example
The dermal filler effect at 1~4 smearing position disappears, and does not play permanent filling effect；And to mouse smear embodiment 1~
7 and the resulting gel of comparative example 1~4 after, smear position do not find it is red, swollen, livid purple etc. reaction.
The result shows that gelling properties of the invention are stablized, after subcutaneous smear, has no stimulation of the skin, deposited locally
Stay the time long, plasticity is good, and the effect that smoothes away wrinkles is obvious, is suitable for beauty and medical application.
Finally, it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention rather than protects to the present invention
The limitation of range is protected, although the invention is described in detail with reference to the preferred embodiments, those skilled in the art should
Understand, it can be with modification or equivalent replacement of the technical solution of the present invention are made, without departing from the essence of technical solution of the present invention
And range.
Claims (10)
1. a kind of gel, which is characterized in that comprise the following components in parts by weight: 1~25 part of l-lactic acid, hyaluronic acid 2~
35 parts, 1~25 part of polyethylene glycol.
2. gel as described in claim 1, which is characterized in that comprise the following components in parts by weight: 15 parts of l-lactic acid, thoroughly
Bright 20 parts, 20 parts of polyethylene glycol of matter acid.
3. gel as described in claim 1, which is characterized in that further include the component of following parts by weight: carboxymethyl cellulose 1~
10 parts, 1~5 part of plant extracts, 1~10 part of antioxidant, 1~5 part of lidocaine.
4. gel as claimed in claim 3, which is characterized in that further include the component of following parts by weight: carboxymethyl cellulose 5
Part, 3 parts of plant extracts, 5 parts of antioxidant, 3 parts of lidocaine.
5. gel as claimed in claim 3, which is characterized in that the antioxidant be arbutin, vitamin C, vitamin E,
At least one of superoxide dismutase.
6. gel as claimed in claim 3, which is characterized in that the plant extracts is safranine flower extract, Radix Angelicae Sinensis extraction
At least one of object, tuckahoe extracts, camomile extract, Rhizoma Atractylodis Macrocephalae extract.
7. the preparation method of gel as described in any one of claims 1 to 6, which comprises the following steps:
(1) hyaluronic acid gel is made in hyaluronic acid；
(2) other components in addition to hyaluronic acid are mixed according to the ratio and are dissolved in hyaluronic acid gel made from step (1),
Obtain gel.
8. the preparation method of gel as claimed in claim 7, which is characterized in that in the step (1), hyaluronic acid gel
After hyaluronic acid is dissolved in water, crosslinking agent is added, is swollen to it.
9. the preparation method of gel as claimed in claim 8, which is characterized in that in the step (1), the dosage of water is transparent
10 times of matter acid weight, the dosage of crosslinking agent are 0.05 times of hyaluronic acid weight, and the crosslinking agent is 1,4-butanediol shrink
At least one of glycerin ether, adipic dihydrazide.
10. such as gel according to any one of claims 1 to 6 answering in the gel that preparation is used for beauty or medical application
With.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811112895.2A CN109331224B (en) | 2018-09-21 | 2018-09-21 | Gel and preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811112895.2A CN109331224B (en) | 2018-09-21 | 2018-09-21 | Gel and preparation method and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109331224A true CN109331224A (en) | 2019-02-15 |
| CN109331224B CN109331224B (en) | 2021-08-06 |
Family
ID=65306590
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811112895.2A Active CN109331224B (en) | 2018-09-21 | 2018-09-21 | Gel and preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109331224B (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110302430A (en) * | 2019-07-03 | 2019-10-08 | 上海交通大学医学院附属第九人民医院 | Biological 3D printing implanted gel and its application in facial soft tissue defect repair |
| CN111012953A (en) * | 2019-12-10 | 2020-04-17 | 华熙生物科技股份有限公司 | Preparation method of enzymolysis-resistant cross-linked hyaluronic acid gel, obtained product and application |
| CN114042189A (en) * | 2021-11-09 | 2022-02-15 | 无锡本物医疗器械有限公司 | Injection type filler composition and preparation method and application thereof |
| CN114686005A (en) * | 2022-04-01 | 2022-07-01 | 上海医妃医药科技有限公司 | Blend of collagen and levorotatory polylactic acid |
| CN116440319A (en) * | 2023-05-15 | 2023-07-18 | 湖南美媛本草生物工程有限公司 | Preparation method and application of medical repair hydrogel |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102911380A (en) * | 2012-10-29 | 2013-02-06 | 北京爱美客生物科技有限公司 | Hyaluronan and biodegradable high polymer modified material and preparation method |
| CN105126166A (en) * | 2015-09-17 | 2015-12-09 | 北京爱美客生物科技有限公司 | Injection amphiphilic-microsphere-containing hyaluronic acid mixed gel and preparation method thereof |
| CN106902387A (en) * | 2017-03-18 | 2017-06-30 | 浙江臻我生物技术有限公司 | A kind of composition for skin filling and preparation method thereof |
| CN107335098A (en) * | 2017-07-12 | 2017-11-10 | 江苏西宏生物医药有限公司 | A kind of injection implant of performance improvement |
-
2018
- 2018-09-21 CN CN201811112895.2A patent/CN109331224B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102911380A (en) * | 2012-10-29 | 2013-02-06 | 北京爱美客生物科技有限公司 | Hyaluronan and biodegradable high polymer modified material and preparation method |
| CN105126166A (en) * | 2015-09-17 | 2015-12-09 | 北京爱美客生物科技有限公司 | Injection amphiphilic-microsphere-containing hyaluronic acid mixed gel and preparation method thereof |
| CN106902387A (en) * | 2017-03-18 | 2017-06-30 | 浙江臻我生物技术有限公司 | A kind of composition for skin filling and preparation method thereof |
| CN107335098A (en) * | 2017-07-12 | 2017-11-10 | 江苏西宏生物医药有限公司 | A kind of injection implant of performance improvement |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110302430A (en) * | 2019-07-03 | 2019-10-08 | 上海交通大学医学院附属第九人民医院 | Biological 3D printing implanted gel and its application in facial soft tissue defect repair |
| CN110302430B (en) * | 2019-07-03 | 2021-06-29 | 上海交通大学医学院附属第九人民医院 | Biological 3D printing implantation gel and application thereof in soft tissue defect repair |
| CN111012953A (en) * | 2019-12-10 | 2020-04-17 | 华熙生物科技股份有限公司 | Preparation method of enzymolysis-resistant cross-linked hyaluronic acid gel, obtained product and application |
| CN111012953B (en) * | 2019-12-10 | 2022-03-29 | 华熙生物科技股份有限公司 | Preparation method of enzymolysis-resistant cross-linked hyaluronic acid gel, obtained product and application |
| CN114042189A (en) * | 2021-11-09 | 2022-02-15 | 无锡本物医疗器械有限公司 | Injection type filler composition and preparation method and application thereof |
| CN114686005A (en) * | 2022-04-01 | 2022-07-01 | 上海医妃医药科技有限公司 | Blend of collagen and levorotatory polylactic acid |
| CN116440319A (en) * | 2023-05-15 | 2023-07-18 | 湖南美媛本草生物工程有限公司 | Preparation method and application of medical repair hydrogel |
Also Published As
| Publication number | Publication date |
|---|---|
| CN109331224B (en) | 2021-08-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN109331224A (en) | A kind of gel and its preparation method and application | |
| KR102372049B1 (en) | Cosmetic gel sheet and production method therefor | |
| Duranti et al. | Injectable hyaluronic acid gel for soft tissue augmentation: A clinical and histological study | |
| RU2320318C2 (en) | Temperature sensitive state changing hydrogel composition and method for production thereof | |
| US8685944B2 (en) | Viscoelastic gel for dermatological use | |
| CN105147590B (en) | A kind of anti-wrinkle eye cream and preparation method thereof | |
| KR102098427B1 (en) | Hyaluronic acid gel and method for producing same | |
| CN102229705B (en) | Collagen temperature-sensitive hydrogel and preparation method thereof | |
| CN106137786B (en) | A kind of anti-ageing composition of hyaluronic acid and its preparation method and application | |
| CN113616566B (en) | Skin care essence for tightening skin and preparation method thereof | |
| CN109045460A (en) | A kind of microneedle patch and preparation method thereof | |
| CN103071191A (en) | Preparation method of autologous platelet-factor-rich plasma (PFRP) preparation | |
| JP7209381B2 (en) | COSMETIC ALCOGEL SHEET AND METHOD FOR MANUFACTURING SAME | |
| CN114306095A (en) | A kind of microneedle patch for anti-wrinkle moisturizing and preparation method and application thereof | |
| CN109044907A (en) | Painless transdermal beauty microneedle patch of one kind and preparation method thereof | |
| CN106905545A (en) | The preparation method of cross-linked hyaluronic acid gel, needle adhesive film and needle adhesive film | |
| CN115873143B (en) | Microsphere with core-shell double-layer structure and preparation method and application thereof | |
| CN109316628A (en) | A kind of gel and its preparation method and application | |
| CN115068688A (en) | Absorbable face filling material and preparation method and application thereof | |
| CN110279887A (en) | A kind of multipurpose photon epoxy resin and preparation method thereof | |
| CN108703895A (en) | A kind of long-acting moisturizing gel and preparation method of percdation | |
| CN101797376A (en) | Preparation method of modified collagen film | |
| JP7429458B2 (en) | Anti-wrinkle composition, anti-wrinkle microneedle patch and method for producing the same | |
| JP7166014B2 (en) | Cosmetic gel sheet and manufacturing method thereof | |
| CN115430031A (en) | Multifunctional cosmetic microneedle patch and batch preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20210629 Address after: 510000 unit 01, 30 / F, poly Tianmu Plaza, 832 Yuejiang Middle Road, Haizhu District, Guangzhou City, Guangdong Province (office only) Applicant after: GUANGZHOU YUANXIANG BIOTECHNOLOGY Co.,Ltd. Address before: 510000 1110, no.16-1, Machang Road, Tianhe District, Guangzhou City, Guangdong Province Applicant before: Chen Jiongfeng |
|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CP01 | Change in the name or title of a patent holder | ||
| CP01 | Change in the name or title of a patent holder |
Address after: 510000 unit 01, 30 / F, poly Tianmu Plaza, 832 Yuejiang Middle Road, Haizhu District, Guangzhou City, Guangdong Province (office only) Patentee after: Guangzhou Yuanxiang Biotechnology Co.,Ltd. Address before: 510000 unit 01, 30 / F, poly Tianmu Plaza, 832 Yuejiang Middle Road, Haizhu District, Guangzhou City, Guangdong Province (office only) Patentee before: GUANGZHOU YUANXIANG BIOTECHNOLOGY CO.,LTD. |