CN109310676A - 一种苯酚衍生物和依托咪酯的药物组合物、药物制剂及其用途 - Google Patents
一种苯酚衍生物和依托咪酯的药物组合物、药物制剂及其用途 Download PDFInfo
- Publication number
- CN109310676A CN109310676A CN201780035396.5A CN201780035396A CN109310676A CN 109310676 A CN109310676 A CN 109310676A CN 201780035396 A CN201780035396 A CN 201780035396A CN 109310676 A CN109310676 A CN 109310676A
- Authority
- CN
- China
- Prior art keywords
- compound
- etomidate
- logical formula
- pharmaceutical preparation
- pharmaceutical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Medicinal Preparation (AREA)
Abstract
本发明涉及一种含苯酚衍生物和依托咪酯的药物组合物及其制备方法和在中枢神经领域的应用，所述苯酚衍生物为式(I)化合物或者其立体异构体、药学上可接受的盐或前药。
Description
PCT国内申请，说明书已公开。
Claims (34)
- PCT国内申请，权利要求书已公开。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011151583.XA CN112245426A (zh) | 2016-07-22 | 2017-07-13 | 一种苯酚衍生物和依托咪酯的药物组合物、药物制剂及其用途 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2016105843385 | 2016-07-22 | ||
| CN201610584338 | 2016-07-22 | ||
| PCT/CN2017/092722 WO2018014770A1 (zh) | 2016-07-22 | 2017-07-13 | 一种苯酚衍生物和依托咪酯的药物组合物、药物制剂及其用途 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202011151583.XA Division CN112245426A (zh) | 2016-07-22 | 2017-07-13 | 一种苯酚衍生物和依托咪酯的药物组合物、药物制剂及其用途 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109310676A true CN109310676A (zh) | 2019-02-05 |
Family
ID=60991913
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202011151583.XA Pending CN112245426A (zh) | 2016-07-22 | 2017-07-13 | 一种苯酚衍生物和依托咪酯的药物组合物、药物制剂及其用途 |
| CN201780035396.5A Pending CN109310676A (zh) | 2016-07-22 | 2017-07-13 | 一种苯酚衍生物和依托咪酯的药物组合物、药物制剂及其用途 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202011151583.XA Pending CN112245426A (zh) | 2016-07-22 | 2017-07-13 | 一种苯酚衍生物和依托咪酯的药物组合物、药物制剂及其用途 |
Country Status (2)
| Country | Link |
|---|---|
| CN (2) | CN112245426A (zh) |
| WO (1) | WO2018014770A1 (zh) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110063947A (zh) * | 2018-01-24 | 2019-07-30 | 四川海思科制药有限公司 | 苯酚衍生物用于制备麻醉药物中的用途 |
| CN114073675A (zh) * | 2020-08-10 | 2022-02-22 | 复旦大学 | 一种丙泊酚混合胶束及其制备方法 |
| CN114668720A (zh) * | 2020-12-24 | 2022-06-28 | 远大生命科学(武汉)有限公司 | 一种依托咪酯乳状注射液及其制备方法 |
| CN115968279A (zh) * | 2020-05-29 | 2023-04-14 | 四川海思科制药有限公司 | 一种药物制剂及其制备方法 |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115175887B (zh) * | 2021-01-28 | 2023-08-01 | 天地恒一制药股份有限公司 | 苯酚衍生物及其在医药上的应用 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103356609A (zh) * | 2012-03-28 | 2013-10-23 | 陈希璇 | 一种复方静脉麻醉剂 |
| WO2016034079A1 (zh) * | 2014-09-04 | 2016-03-10 | 四川海思科制药有限公司 | 一种gabaa受体增强剂用于制备镇静麻醉的药物中的用途 |
-
2017
- 2017-07-13 CN CN202011151583.XA patent/CN112245426A/zh active Pending
- 2017-07-13 WO PCT/CN2017/092722 patent/WO2018014770A1/zh active Application Filing
- 2017-07-13 CN CN201780035396.5A patent/CN109310676A/zh active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103356609A (zh) * | 2012-03-28 | 2013-10-23 | 陈希璇 | 一种复方静脉麻醉剂 |
| WO2016034079A1 (zh) * | 2014-09-04 | 2016-03-10 | 四川海思科制药有限公司 | 一种gabaa受体增强剂用于制备镇静麻醉的药物中的用途 |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110063947A (zh) * | 2018-01-24 | 2019-07-30 | 四川海思科制药有限公司 | 苯酚衍生物用于制备麻醉药物中的用途 |
| CN115968279A (zh) * | 2020-05-29 | 2023-04-14 | 四川海思科制药有限公司 | 一种药物制剂及其制备方法 |
| CN114073675A (zh) * | 2020-08-10 | 2022-02-22 | 复旦大学 | 一种丙泊酚混合胶束及其制备方法 |
| CN114668720A (zh) * | 2020-12-24 | 2022-06-28 | 远大生命科学(武汉)有限公司 | 一种依托咪酯乳状注射液及其制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2018014770A1 (zh) | 2018-01-25 |
| CN112245426A (zh) | 2021-01-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Klang et al. | Design and evaluation of submicron emulsions as colloidal drug carriers for intravenous administration | |
| CN109310676A (zh) | 一种苯酚衍生物和依托咪酯的药物组合物、药物制剂及其用途 | |
| PL219338B1 (pl) | Preparat do podawania donosowego zawierający co najmniej jeden będący lekiem hormon płciowy wybrany spośród testosteronu, biologicznych proleków hormonu płciowego wybranych spośród androstendionu i progesteronu oraz ich połączeń, oraz dalsze składniki | |
| TW201138782A (en) | Low-oil pharmaceutical emulsion compositions comprising progestogen | |
| CN110251463A (zh) | 含激素的乳液 | |
| UA82510C2 (uk) | Фармацевтичні композиції для достовірного досягнення прийнятних рівнів тестостерону в сироватці та їх застосування | |
| CN104940939B (zh) | 大剂量甘油在可耐受冻融脂肪乳剂中的应用 | |
| US20050101517A1 (en) | Novel testosterone ester formulation for human use | |
| EP2922542A1 (en) | Methods and compositions for locally increasing body fat | |
| EP1476195B1 (en) | Enhancement of the action of central and peripheral nervous system agents | |
| US5677341A (en) | Emulsion suitable for administering a sphingolipid | |
| FI98047C (fi) | Röntgenvarjoaineena käytettävä jodipitoinen emulsio | |
| CZ240297A3 (cs) | Transdermální přípravek | |
| CN101524329B (zh) | 双环醇亚微乳及其制备方法 | |
| EP1558226B1 (en) | Method for cardioprotection and neuroprotection by intravenous administration of halogenated volatile anesthetics | |
| CN115517984A (zh) | 氧气缓释型纳米乳液组合物以及其制备方法 | |
| FI99080C (fi) | Menetelmä ruoansulatuskanavan ulkopuoliseen annosteluun tarkoitettujen emulsioiden valmistamiseksi | |
| RU2141313C1 (ru) | Фармацевтическая эмульсия, содержащая биологически активные стероиды, и способ получения эмульсии | |
| JP4942905B2 (ja) | 神経保護活性を有する７−ヒドロキシエピアンドロステロン | |
| CN110339164A (zh) | 酮咯酸酯类衍生物静脉注射脂肪乳剂、制备方法和应用 | |
| CN1739519B (zh) | 伊曲康唑注射乳剂及其制备方法 | |
| CN109985005A (zh) | 氟比洛芬酯脂肪乳及其制备方法 | |
| US5610182A (en) | Pharmaceutical composition for the therapy of cerebral thrombosis |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190205 |
|
| RJ01 | Rejection of invention patent application after publication |