CN109297758A - A kind of fully automatic liquid processing system - Google Patents
A kind of fully automatic liquid processing system Download PDFInfo
- Publication number
- CN109297758A CN109297758A CN201710649264.3A CN201710649264A CN109297758A CN 109297758 A CN109297758 A CN 109297758A CN 201710649264 A CN201710649264 A CN 201710649264A CN 109297758 A CN109297758 A CN 109297758A
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- syringe pump
- mechanical arm
- liquid
- controller
- processing system
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- 239000007788 liquid Substances 0.000 title claims abstract description 61
- 238000012545 processing Methods 0.000 title claims abstract description 13
- 238000012546 transfer Methods 0.000 claims abstract description 19
- 239000003153 chemical reaction reagent Substances 0.000 claims abstract description 13
- 238000000605 extraction Methods 0.000 claims abstract description 9
- 238000002474 experimental method Methods 0.000 claims abstract description 7
- 239000000284 extract Substances 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 238000005299 abrasion Methods 0.000 claims description 2
- 238000013507 mapping Methods 0.000 claims description 2
- 239000002904 solvent Substances 0.000 claims description 2
- 230000009897 systematic effect Effects 0.000 claims description 2
- 238000012360 testing method Methods 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 description 13
- 238000000034 method Methods 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 238000005070 sampling Methods 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 239000012086 standard solution Substances 0.000 description 4
- 238000013461 design Methods 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 229910001385 heavy metal Inorganic materials 0.000 description 2
- 239000012452 mother liquor Substances 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 description 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 1
- 229910002651 NO3 Inorganic materials 0.000 description 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
- IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 241000251131 Sphyrna Species 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 239000005864 Sulphur Substances 0.000 description 1
- XKMRRTOUMJRJIA-UHFFFAOYSA-N ammonia nh3 Chemical compound N.N XKMRRTOUMJRJIA-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000003575 carbonaceous material Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000004020 conductor Substances 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 238000012864 cross contamination Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
- G01N1/14—Suction devices, e.g. pumps; Ejector devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/38—Diluting, dispersing or mixing samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Plasma & Fusion (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Hydrology & Water Resources (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
The present invention relates to a kind of fully automatic liquid processing system, including controller, syringe pump, mechanical arm, image identification system, pipette tips adapter and balance for putting instrument；The syringe pump is used for the extraction or discharge of liquid comprising the pump housing and the screw rod that can be moved back and forth in the pump housing, the screw rod realize the extraction or discharge of liquid according to setting value in the case where the motor that controller controls drives；The mechanical arm is connect with syringe pump, under control of the controller, realizing mechanical arm in the transfer of the liquid such as the positioning of reagent position and sample position and syringe pump reagent；The syringe pump is provided with pipette tips adapter, controller is according to requirement of experiment, the disposable liquid transfer gun head of different volumes is identified by image identification system, and it controls mechanical arm and chooses corresponding disposable liquid transfer gun head automatically, completely instead of the manually operated alternative of project above in laboratory, have many advantages, such as that easy to operate, precision is high.
Description
Technical field
The present invention relates to Bioexperiment device field, specifically a kind of fully automatic liquid processing system.
Background technique
When now carrying out the preparation of standard curve various concentration point in the lab, pipette, liquid-transfering gun and appearance are generally used
Measuring bottle is prepared, and in process for preparation, manual operations is complicated, may bring human error into liquid-transfering gun use process；Simultaneously
Volumetric flask carries out needing artificial eye judge the terminal of constant volume when constant volume, can generate human error.
Summary of the invention
The technical problem to be solved by the present invention is to for existing deficiency during the experiment, we design a kind of full-automatic
Liquid processing system, using high-precision, the preparation of the syringe pump of high stability and disposable liquid transfer gun head progress solution and reagent
Addition etc..
The technical scheme to solve the above technical problems is that
A kind of fully automatic liquid processing system, including controller, syringe pump (2), mechanical arm (1), image identification system, one
Secondary property pipette tips adapter (5) and balance (7) for putting instrument；The syringe pump (2) is used for the extraction or discharge of liquid,
Including the pump housing and the screw rod that can be moved back and forth in the pump housing, the screw rod is in the case where the motor that controller controls drives, according to setting
Value realizes the extraction or discharge of liquid；The mechanical arm (1) connect with syringe pump (2), under control of the controller, realizing machine
Tool arm (1) reagent position (6) and sample position positioning and pass through syringe pump extract release reagent；The syringe pump (2) is provided with
Disposable pipette tips adapter (5), controller identify the disposable of different volumes by image identification system according to requirement of experiment
Liquid transfer gun head (4), and control mechanical arm (1) and choose corresponding disposable liquid transfer gun head (4) automatically.
Further, the mechanical arm (1) is X, Y, Z axis mechanical arm；The controller control stepper motor rotation, thus
Belt system is driven, keeps mechanical arm (1) mobile；
Further, the volume of the disposable liquid transfer gun head (4) is respectively 1ml and 5ml.
Further, the balance (7) is respectively arranged with centrifuge tube, test tube and solvent bottle, the balance in fixed position
(7) position mapping is established with syringe pump (2) and mechanical arm, controller controls mechanical arm (2) according to requirement of experiment and is moved to accordingly
Position, and extracted by syringe pump and release reagent.
Further, syringe pump (2) is provided with correction component, can eliminate the systematic error generated by abrasion.
The beneficial effects of the present invention are: identifying the disposable liquid transfer gun head of 1mL and 5mL by controller automatization, and root
The liquid transfer gun head needed is chosen in the automation that specifically carries out factually tested, and automation carries out standard using disposable liquid transfer gun head
The preparation of curve concentration point, the preparation of Dan Biao, mixed mark, single mark gradient, mixed mark gradient, mark-on reclaims, carries out water sample transfer, water sample
The addition function of the reagents such as middle addition color developing agent, the completely manually operated alternative instead of project above in laboratory, have behaviour
Make the advantages that easy, precision is high.
Detailed description of the invention
Fig. 1 is structure of the invention block diagram；
Fig. 2 is structure of the invention figure；
Wherein appended drawing reference label is as follows:
1, mechanical arm, 2, syringe pump, 3, shell, 4, disposable liquid transfer gun head, 5, disposable pipette tips adapter, 6, reagent
Position, 7, balance；
Specific embodiment
The principle and features of the present invention will be described below with reference to the accompanying drawings, and the given examples are served only to explain the present invention, and
It is non-to be used to limit the scope of the invention.
As shown in Figs. 1-2, a kind of fully automatic liquid processing system, including controller, syringe pump (2), mechanical arm (1), figure
As identifying system, disposable pipette tips adapter (5) and the balance (7) for putting instrument；The syringe pump (2) is for liquid
It extracts or is discharged comprising the pump housing and the screw rod that can be moved back and forth in the pump housing, the motor band that the screw rod is controlled in controller
Under dynamic, the extraction or discharge of liquid are realized according to setting value；The mechanical arm (1) connect with syringe pump (2), in controller
Under control, realize that mechanical arm (1) extracts release reagent in the positioning of reagent position (6) and sample position, and by syringe pump；The note
It penetrates pump (2) and is provided with disposable pipette tips adapter (5), controller is identified not according to requirement of experiment by image identification system
The disposable liquid transfer gun head (4) of same volume, and control mechanical arm (1) and choose corresponding disposable liquid transfer gun head (4) automatically.
Fully automatic liquid processing system is used to carry out the pre-treatment work of laboratory fluids, its major function is to be marked
The preparation of quasi- solution, the preparation of standard curve concentration point, the preparation of heavy metal mixed standard solution, heavy metal blended standard curve
The preparation of point.The automatic transfer of liquid, the automatic of water sample is distributed, the mark-on of recovery of standard addition water sample is tested, examination is reacted in water sample
The addition of agent and water sample condition reagent.
System by the calculating and control of software, then and pick up disposable liquid transfer gun head (disposable pipette tips avoid by automatic choosing
Take the cross contamination that different liquids are brought into), the disposable pipette tips of instrument automatic Picking 1mL when sample volume is less than 1mL, when
The disposable pipette tips of instrument automatic Picking 5mL when sample volume is greater than 1mL.
Instrument uses disposable pipette tips adapter when taking liquid, and disposable pipette tips adapter is accurate in x, y, z mechanical arm
Positioning is lower to pick up disposable pipette tips (automatically selecting 1mL or 5mL, disposable pipette tips are carbon material category conductive material), takes liquid process
Middle mechanical arm liquid level conduction whether can be contacted according to pipette tips come carry out liquid level follow sampling (i.e. instrument has the function of detecting liquid level,
The instrument alarm when sample deficiency guarantees that sample size is sufficient when sampling；Liquid level follows sampling that can effectively reduce liquid to remain on
On sampling hammerhead, the precision of instrument is influenced), when taking that disposable pipette tips do not contact liquid level when liquid, software systems are not received
Conductive signal, mechanical arm can (flow direction) be mobile downwards always；When disposable pipette tips contact liquid level, software systems can be connect
Receive conductive signal, mechanical arm stops movement, and instrument will do it the extraction of liquid, and during Liquid extracting, mechanical arm can root
Liquid level is detected automatically according to the decline of liquid level and is declined with liquid level.
Work system, in solution process for preparation, it is only necessary to which user of service inputs raw water sample index, and the water sample to be prepared
Index, instrument is calculated and run automatically, and (example: the preparation of standard solution need to only input concentration, the mother liquor position of mother liquor
It sets；With the position of the concentration for needing the standard solution prepared, the volume for needing to prepare and standard solution preparation bottle, instrument meeting
Automatic solution preparation is carried out according to the setting of software.)
The present invention has the advantage that
1, batch samples are quickly automatically finished sample-adding, mix, the pretreatment process such as dilution；
2, high-precision liquid relief: the sample transfer of 1uL rank；
3, mature mechanical arm design, high speed accurately complete sample handling processes；
4, process open by design: sample treatment can be established according to the demand of each analysis project；
5, new sample treatment can be developed according to user demand；
6, the schemes such as built-in mixed mark, Dan Biao, gradient dilution；Built-in total phosphorus, total nitrogen, ammonia nitrogen, nitrate, nitrite, sulphur
The national standard methods sample allocation plan such as compound, cyanide, basicity, hardness, fluoride, chloride, phosphate, sulfate, can be with
Call directly operation；
7, standard curve: one-key operation, quick and precisely；
8, level detection: automatic detection of liquid level liquid level is automatically stopped on liquid level, and it is settable to sink to level, is reduced
Outer wall hanging liquid measure utmostly improves precision when liquid separation；
9, using disposable TIP operating mode, disposable TIP head is taken/moved back automatically.
The foregoing is merely presently preferred embodiments of the present invention, is not intended to limit the invention, it is all in spirit of the invention and
Within principle, any modification, equivalent replacement, improvement and so on be should all be included in the protection scope of the present invention.
Claims (5)
1. a kind of fully automatic liquid processing system, including it is controller, syringe pump (2), mechanical arm (1), image identification system, primary
Property pipette tips adapter (5) and the balance (7) for putting instrument；The syringe pump (2) is used for the extraction or discharge of liquid, packet
The screw rod that includes the pump housing and can move back and forth in the pump housing, the screw rod is in the case where the motor that controller controls drives, according to setting value
Realize the extraction or discharge of liquid；The mechanical arm (1) connect with syringe pump (2), mechanical under control of the controller, realizing
Arm (1) reagent position (6) and sample position positioning and pass through syringe pump extract release reagent；The syringe pump (2) is connected with one
Secondary property pipette tips adapter (5), controller identify the disposable shifting of different volumes by image identification system according to requirement of experiment
Liquid pipette tips (4), and control mechanical arm (1) and choose corresponding disposable liquid transfer gun head (4) automatically and examination is released by syringe pump extraction
Agent.
2. a kind of fully automatic liquid processing system according to claim 1, it is characterised in that: the mechanical arm (1) be X,
Y, Z axis mechanical arm；The controller control stepper motor rotation keeps mechanical arm (1) mobile to drive belt system.
3. a kind of fully automatic liquid processing system according to claim 1, it is characterised in that: the disposable liquid transfer gun head
(4) volume is respectively 1ml and 5ml.
4. a kind of fully automatic liquid processing system according to claim 1, it is characterised in that: the balance (7) is in fixation
Position is respectively arranged with centrifuge tube, test tube and solvent bottle, and the balance (7) and syringe pump (2) and mechanical arm establish position mapping,
Controller controls syringe pump (2) according to requirement of experiment and is moved to corresponding position.
5. a kind of fully automatic liquid processing system according to claim 1, it is characterised in that: syringe pump (2) is provided with strong
Positive component can eliminate the systematic error generated by abrasion.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710649264.3A CN109297758A (en) | 2017-07-25 | 2017-07-25 | A kind of fully automatic liquid processing system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710649264.3A CN109297758A (en) | 2017-07-25 | 2017-07-25 | A kind of fully automatic liquid processing system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109297758A true CN109297758A (en) | 2019-02-01 |
Family
ID=65168052
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710649264.3A Pending CN109297758A (en) | 2017-07-25 | 2017-07-25 | A kind of fully automatic liquid processing system |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109297758A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112697569A (en) * | 2019-10-23 | 2021-04-23 | 天津市恒奥科技发展有限公司 | Full-automatic dilution instrument and liquid dilution method |
| CN116083225A (en) * | 2023-03-07 | 2023-05-09 | 苏州君跻基因科技有限公司 | Automated control system, method and apparatus for pipetting workstations |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130280143A1 (en) * | 2010-11-23 | 2013-10-24 | Andrew Alliance S.A. | Devices and methods for programmable manipulation of pipettes |
| CN106840797A (en) * | 2017-01-24 | 2017-06-13 | 上海析维医疗科技有限公司 | The automatic preparation work station and compound method of a kind of standard liquid |
| CN206930487U (en) * | 2017-07-25 | 2018-01-26 | 上海昂鹭生物技术有限公司 | A kind of fully automatic liquid processing system |
-
2017
- 2017-07-25 CN CN201710649264.3A patent/CN109297758A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130280143A1 (en) * | 2010-11-23 | 2013-10-24 | Andrew Alliance S.A. | Devices and methods for programmable manipulation of pipettes |
| CN106840797A (en) * | 2017-01-24 | 2017-06-13 | 上海析维医疗科技有限公司 | The automatic preparation work station and compound method of a kind of standard liquid |
| CN206930487U (en) * | 2017-07-25 | 2018-01-26 | 上海昂鹭生物技术有限公司 | A kind of fully automatic liquid processing system |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112697569A (en) * | 2019-10-23 | 2021-04-23 | 天津市恒奥科技发展有限公司 | Full-automatic dilution instrument and liquid dilution method |
| CN116083225A (en) * | 2023-03-07 | 2023-05-09 | 苏州君跻基因科技有限公司 | Automated control system, method and apparatus for pipetting workstations |
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