CN109289123A - A Spinal Rehabilitation System Combining Various Means - Google Patents

Abstract

The spine recovering system that multiple means combine.The spine recovering system is treated for the slight contracture of muscle caused by the reasons such as modern's bad life habits and disease and muscle tonue.Wherein containing there are many facilitating bone and avoid the drug of ectopic osteogenesis, the drug being discharged in tissue space selectively by special clad, and be arranged by magnetic field in affected part enrichment.For the activity for improving the drug, the present invention also increases the device for forming neuromere interference and artificial weakly alkaline environment etc..The present invention improves muscle, neurological health index by human body muscle tonue related neural section induced discharge effectively, promotes wound healing；It adjusts in combination with checking with EMG method real-time perfoming adaptivity to obtain better healing effect.In order to realize better incision opportunity during above-mentioned electric magnetic medical, instruction device prompt patient carries out abdominal respiration to cooperate magnetic therapy under control device management, avoids Evoked ptential and the cardiac electrical excessive interference of normal human.

Description

A Spinal Rehabilitation System Combining Various Means

technical field

The present application relates to rehabilitation of orthopedic injuries, especially to the field of spinal rehabilitation, and in particular to a rehabilitation device for the spine and related nerves and muscles.

Background technique

Due to sitting work, bad living habits and diseases or some reasons, modern people have long been in a fixed posture for a certain part of the body, and the muscles have been in a state of low load and continuous contraction for a long time. This leads to a decrease in water content in fibrous tissue matrices such as ligaments, reduced viscoelasticity, and reduced inter-fiber lubrication. At the same time, the distance between the fibers is shortened and the contact period is prolonged, which may lead to the formation of chemical transverse bonds between the fibers, resulting in the occurrence of adhesions between the fibers. In this group of people, new fibers are often caused by chronic inflammation of the muscle tissue. These new fibers are disordered and form adhesions with the original fibers again, which further restricts the sliding between fibers. Over time, this "vicious cycle" will cause slight contractures in the muscles, causing muscle tension. The lifestyle of modern people determines that most of these muscle tensions occur in the attachment of the spine or related muscle groups, which will lead to spinal fatigue, overload and even irreversible damage over time. Of particular concern is that most muscle fatigue or injury is accompanied by strain or hyperplasia of the associated bone.

In the field of spinal rehabilitation, the implementation of spinal traction and fixation while relieving muscle tension by applying machinery and electric fields has proved to be an effective treatment method. However, this process will inevitably cause unnecessary damage to the spine, and even cause spinal cord injury (SCI), and medical workers are often reluctant to adopt active treatment programs in order to avoid SCI; Accidental massage injuries also often occur during procedures such as non-spinal injury massage. Therefore, it is necessary to provide effective real-time electrophysiological monitoring means when it comes to spinal therapy. How to combine electrophysiological detection with various spinal rehabilitation methods is a promising direction in this field. Obtaining effective and representative data from many electrophysiological indicators and using them to guide the subsequent spinal rehabilitation is also the focus of research in this field.

Neurophysiological examination is a technique for measuring, recording and analyzing the bioelectricity generated by the peripheral nerves of the living body and the electrical characteristics of the living body by relying on various forms of energy stimulation according to the principles of neuroanatomy. Evoked potentials (EPs) refer to specific stimulation (acoustic, light or somatosensory stimulation) given to the nervous system (from receptors to cerebral cortex), or the brain to process the information of stimulation (positive or negative), A detectable bioelectrical response is generated in the corresponding parts of the system and the brain, which has a relatively fixed time interval (time-locking relationship) and a specific phase with the stimulus. It reflects the integrity of the structure and function of synaptic transmission and axonal conduction of cells and molecular systems, and is an effective functional indicator.

Myoelectric signal (EMG) is a bioelectrical signal generated with muscle movement. When a person moves a limb, the neurons in the cerebral cortex that control the movement area are excited and generate electrical impulses of a certain frequency. This electrical impulse precisely conducts specific muscle fibers through the nervous system. When these electrical impulses reach the nerve-muscle synapse , generates an end-plate potential in the muscle fiber, and its depolarization will generate a train of action potentials in the muscle fiber, causing the muscle to contract, allowing the limb to complete the action set by the brain. Surface EMG is a comprehensive physiological and electrical phenomenon generated by various muscle activities in limb movement. The analysis and study of surface EMG can find the corresponding relationship between it and the physiological state of muscles and limb movement patterns, which can be widely used in clinical medicine and sports medicine. , medical rehabilitation and many other fields. In human skeletal muscle, the myofascial trigger point (MTrP) has been widely recognized. Spontaneous electrical activity can be recorded in the MTrP area of the muscle tension zone, and further, muscle tension can also be expressed and detected in the form of electromyography. In short, the muscle expresses its physiological state (physiological state statement focusing on muscle tension in the present invention) through electrophysiological signals; conversely, the muscle tension can also be properly adjusted by the way of external field affecting the electromyography.

In the prior art, there are methods and devices for improving muscle tension by electrically stimulating the patient and receiving the electromyography/biofeedback signal of the patient. But these devices use simple electrode stimulation, the frequency is roughly between 5Hz and 100Hz, and the electrical signal contains a simple waveform. The stimulation effect on the human body is single, and it is easy to cause peripheral nerve fatigue and generate a lot of unnecessary electrode heat. Insertion of electrodes or patch electrodes may result in keratinopathy and unnecessary damage. The patient will have unnecessary imagination about the intuitive electrode stimulation, and this kind of psychology will also lead to the deterioration of the treatment effect. The bottom line is that peripheral nerves may respond well to short-term stimulation, but long-term treatment can lead to nerve fatigue and plummeting effects. The reason is that in the process of evolution, human nerves have an adaptation process for the injury stress reflex generated by external stimuli, and the innervated nerves and muscles can easily reach the refractory period for the purpose of self-protection; This kind of fatigue is less likely to occur, or the fatigue tolerance period is longer.

A ganglion is a nodular structure in which neuronal cell bodies with the same function are assembled in peripheral parts other than the central nervous system. Its surface is covered with a connective tissue membrane that contains blood vessels, nerves, and fat cells. The capsule is connected with the adventitia and perineurium of peripheral nerves, and penetrates deep into the ganglion to form a mesh-like scaffold in the ganglion. The fibers from the nerve cells in the ganglion are distributed to the relevant parts of the body, called postganglionic fibers. According to different physiology and morphology, ganglia can be divided into two types: spinal ganglia (sensory ganglia) and autonomic ganglia. Autonomic ganglia include sympathetic and parasympathetic ganglia. Sympathetic ganglia line both sides of the spine. Parasympathetic ganglia are located near or within the walls of the organs they innervate. Within the ganglion, the axons of the preganglionic neurons form synapses with the postganglionic neurons. The ganglia are connected with the brain and spinal cord through nerve fibers. In the past, people tended to regard the ganglia as the transfer station for the conduction of the central nervous system to the surrounding. But in fact, the inventor found through physiological tests in the laboratory that the bioelectricity generated by the human body is not precisely controllable in amplitude and frequency by stimulating the nervous system including the ganglion, and the bioelectricity helps to promote the nerve function. Controls the rhythmic relaxation and contraction of muscles and connective tissues and the blood circulation of peripheral capillaries. At the same time, the stimulation of the ganglion will also lead to the effect of ascending nerve fibers on the brain. In practice, it has the effect of relieving the tension and anxiety of patients, and has a certain therapeutic effect on muscle tension caused by nerves. Moreover, specific ganglia can be selectively excited or inhibited in various ways to achieve the effect of simulating the generation of human nerves, which often have unparalleled effects in the field of neuromedicine. For example, the widely used stellate ganglion block can help restore sympathetic-vagal balance and relieve pain. In the study of the fracture healing of limbs in patients with craniocerebral injury, it was found that denervation caused by craniocerebral injury can promote the increase of the expression of callus collagen in the early stage of fracture healing. Sexual paralysis. A large number of cartilaginous callus can quickly repair the injury and restore nerve and bone structure in the early stage of healing. This denervation state has a positive effect on fracture healing, but at this stage, animal denervation models are created in the field by injuring the brain with a heavy hammer, and clinically, certain specific ganglia of patients are blocked by surgery. This practice has great surgical risks and is irreversible, causing irreversible losses to the patient's body and mind.

Taking stellate ganglion block as an example, the previous technique was limited to paraganglionic drug injection, which was both risky and prone to other drug-induced side effects. The invention provides a magnetoelectric stimulation method to perform specific induction work on the corresponding ganglion. However, interference with the ECG signal will inevitably occur during the stimulation process. While shielding, the above-mentioned interference can also be improved by using the ECG-triggered magnetic stimulation circuit, which is also a technical problem to be solved urgently by those skilled in the art. . At the same time, how to accurately locate the stimulation location simply, quickly and non-invasively is a difficult problem that has not been overcome by those skilled in the art. In the past, physiotherapy practitioners often used empirical compression and patient feedback for positioning, which was inaccurate and may cause accidental damage. Of course, some people proposed to measure by adding electrodes, but the laboratory environment is very different from the clinical environment, and the detection cost remains high. At the same time, the requirements for the operator are very high.

SUMMARY OF THE INVENTION

The invention provides a rehabilitation system for relieving and treating patients with spinal injury, spinal fatigue and related muscle group tension. It overcomes the shortcomings of previous rehabilitation devices that can only target a single spine problem, integrates multiple treatment methods, and realizes intelligent treatment under the monitoring of a preset detection program. At the same time, considering the multiple pathogenic mechanisms that may exist in the same appearance of the user, a detection and judgment logic combining multiple detection means is adopted, so that the device can make appropriate physiotherapy according to the user's specific situation. Thereby achieving effective and safe spinal rehabilitation and avoiding unnecessary secondary injury or delay.

The rehabilitation device mentioned in the present invention includes an electromyography detection module 1, a magnetic therapy module 2, a massage module 3, a control module 4, a display module 5, an electrocardiogram module 6, a bone injury module 7, and the like.

The invention relates to the fields of electrophysiology and electromagnetic medicine. The well-known electromyography (EMG) signal has its own characteristics in amplitude and spectrum: the surface EMG signal measured from the surface of the human body is usually very weak, and the amplitude generally does not exceed 5mV; the frequency is also relatively low, and the spectrum range is generally 0.02 -1000Hz, the spectral energy is mainly concentrated between 0.25 and 350Hz. There is a good linear relationship between the degree of muscle relaxation and tension and the amplitude of the generated surface EMG voltage. The root mean square method is used to measure the EMG voltage amplitude, which can not only reflect the change characteristics of the EMG signal amplitude in the time dimension, but also depend on the internal relationship between the muscle load factor and the physiological and biochemical processes of the muscle itself. Time domain analysis indicators are often used to reflect the state of muscle activity in real time and without damage, and have good real-time performance. At the same time, the impedance of the muscle part of the human body can effectively express the degree of relaxation of the human body. Generally speaking, the more relaxed the human body is, the smaller the impedance. Therefore, the combination of the above methods can obtain the muscle tension of the human body in real time and accurately, and grade it.

The obtained muscle tone may contain a variety of information, such as bone damage caused by spinal strain, hyperplasia, nerve damage, lactic acid metabolism disorder, pain caused by muscle spasm, and muscle tension caused by external force or psychology. If the different causes of muscle tension cannot be effectively distinguished, targeted treatment cannot be effectively performed. The present invention obtains the real-time electromyography and impedance signals of the human body by arranging an electromyographic signal collector in a specific area of the body surface, and at the same time realizes the identification of the above-mentioned abnormal electromyographic signal through the preset program in the gated logic circuit that can be programmed in real time. and classification, and combine different treatment methods according to different judgment results.

First, transcranial magnetic stimulation (TMS) is performed on the user, and the selected stimulation area is located in the epidural area, which is detected by magnetic field evoked potentials. A simple magnetic stimulator consists of a DC power supply, a charging circuit, an energy storage element, a discharge switch, a charge and discharge control circuit and a coil. Various transcranial magnetic stimulators and control modules including software well known to those skilled in the art are incorporated into the present invention by reference, such as the DTMS transcranial magnetic stimulation circuit device described in US2008200749A or the commercialized US Medtronic Mag Pro type magnetic stimulator.

The excitation generated by magnetic stimulation of the cortical motor area depolarizes the anterior horn cells of the spinal cord or the motor fibers of the peripheral nerve through the descending conduction pathway, and the potential changes recorded in the corresponding muscles, nerves, and spinal cords are motor evoked potential detection stimulation. According to different stimulation modes, SRPs can be divided into sensory evoked potential (SEP) and motion evoked potential (MEP). SEP mainly reflects the functional status of the ascending sensory pathway in the dorsal side of the spinal cord, while MEP through transcranial stimulation reflects the integrity of the descending motor pathway in the ventral side of the spinal cord. MEP is helpful to detect whether there is substantial damage to the spine, especially for potential injuries that do not show obvious limb disorders, it has a better detection effect. The study by Maerten, Dvorak et al. pointed out that in spondylosis and disc herniation, the sensitivity of MEP was 84%, which was significantly higher than that of SEP, which was 36%, and the sensitivity of MEP to cervical spinal stenosis was slightly higher than that of lumbar spinal stenosis. It is speculated that the volume of the cervical spinal canal is small, and it is more likely to compress the spinal cord after stenosis. Machida reported that the sensitivity of transcranial induction of MEP in patients with traumatic spinal cord injury was 85%. In order to reach the stimulation site through the skull and scalp, the number of coil turns and the current value are selected so that the peak value of the magnetic field cannot be less than 1 Tesla (T), and generally should be between 1-2T. A flat circular coil (which has a larger stimulation range and is more suitable for peripheral nerves) is placed on the top of the user's skull in a tangential relationship with it. The distance from the top of the user's head is less than 3.5 cm. Because it is only used for physiological detection, the action time is short, and natural cooling or air cooling can be used. Fast-frequency TMS is realized at a depth of 1-3 cm in the user's skull through the coil, and the frequency of the time-varying magnetic field generated by the time-varying current is greater than 1 Hz. A common motor potential detector can be used to detect the MEP signal of transcranial magnetic stimulation, and the spinal cord conduction pathway can be detected by analyzing the conventional indicators such as its conduction time and signal size. In this case, mechanical massage of the affected area or related parts should be strictly prohibited to avoid secondary damage to the spine caused by subsequent massage steps.

Second, peripheral nerve conduction pathways can also be detected by MEP. The acquisition method of MEPs (also called MEPs) of peripheral nerves is similar to the existing SEP technology. The anode of the patch guide electrode is set on the abdomen of the target muscle to be tested, and the cathode is set on the descending tendon segment of the nerve to ensure that the electrodes are between the electrodes. The distance is above 35mm. When necessary, subcutaneous microneedle electrodes can be used instead to improve the signal pickup effect and avoid noise interference. At the same time, MEP signals can be picked up in specific limb nerve pathways or ganglia according to the patient's statement, and then the EMG conducted through specific spinal segments can be focused on, and the damage to specific nerve pathways can be qualitatively measured. The selection of the target muscle can be based on the conventional selection criteria for transcranial magnetic stimulation signal detection in the art. In principle, it is better to choose the main muscles of the limbs away from the trunk, and is not limited thereto.

In the waveform signal obtained by MEP detection, the first monophasic positive wave that arrives quickly is called the direct wave (D wave), which is also called the direct wave because its conduction does not pass through synapses; There is a group of positive waves (I waves), which are caused by the indirect excitation of pyramidal cells by contact fibers, which are called indirect waves. The MEP waveform elicited by electrical stimulation indicates normal spinal conduction tract function, while the disappearance of the waveform indicates that the conduction function is blocked. If there is a D wave conduction block, it will be classified by the gated circuit, and mechanical massage is strictly prohibited for possible spinal cord injury to prevent treatment damage. However, when the D wave conduction is normal, and the I wave latency is prolonged (the criterion is roughly 1.5 times the normal duration), it indicates that there is inflammation or damage to the peripheral nerves, such as overwork and other symptoms of demyelination. Injury Rehabilitation Work Mode 2-3. Clinical experiments have shown that when the patient is awake without anesthesia, more than two consecutive transcranial magnetic stimulation can effectively simulate the normal evoked signal. Moderate mechanical massage combined with magnetic field-induced electromyography can help activate neurons and conduction pathways.

Finally, the electromyography detection module also includes a pickup device for electromyography (eg, surface electromyography signals), so as to detect the electrical conductivity of nerves. After the MEP detection is completed, it is judged that the patient does not have diseases that are not suitable for mechanical massage, such as severe spinal cord or nerve damage, and the EMG pickup device detects the EMG signal of the specific massage part of the patient in real time. When muscles have pain, spasm or simple fatigue problems, the conduction speed of peripheral nerve fibers at the problem points (including pain points, spasm points and fatigue areas, etc., the same below) slows down and blood circulation is poor. It can be confirmed and differentiated in further detail by the detection of EMG signals.

Recent sports medicine studies have shown that the more slow-twitch muscle fibers in human skeletal muscle, the greater the area percentage, and the slower the MPF decline slope in the frequency domain analysis index of EMG signals. Further, pain, especially chronic long-term pain, can lead to an increase in the proportion and volume of local muscle fast-twitch fibers and a corresponding weakening of slow-twitch fibers, resulting in a significant increase in the slope of MPF decline. For example, it has been clinically found that both pathological inflammation or non-pathological spasm of the teres minor muscle can lead to an increase in the spontaneous firing frequency of the dorsal root ganglia of the spinal cord, which may result in radiating pain in the corresponding lateral root pain and upper limbs. Problem point - there will be high-frequency electrical signals in the relevant nerve tissue around the pain site, which is manifested as a sharp drop in the median frequency, that is, a significant increase in the median frequency slope (MPs). The inventor believes that the high-frequency and rapid discontinuation phenomenon in the process of nerve fiber conduction is an adaptive phenomenon of the body under incomplete block. The high-frequency discontinuity of the electrical signal at the problem point causes the charge of the cells around the organ to change rapidly between increases and decreases.

In the muscle soreness caused by exercise fatigue, the synchronization of motor unit excitation is strengthened to maintain muscle tension during fatigue; as well as the obstruction of blood flow caused by the increase in intramuscular pressure and the excessive excitation of the sarcolemma caused by the accumulation of lactic acid, resulting in Decreased muscle fiber conduction velocity, which can be a dominant indicator of post-exercise fatigue. Through massage and physiotherapy, the amplitude of EMG can be slowly increased, and the average power frequency (MPF) of EMG signal can also increase at the same time. normal.

The sampling frequency of the electrodes for detecting pain signals is 300Hz-500Hz, preferably 450Hz; the sampling frequency of the fatigue signal detection electrodes is 8-300Hz, preferably 20-100Hz, more preferably 50Hz. The common mode rejection ratio is greater than 120dB, and the sensitivity is 1μV. The pick-up electrode uses an active surface electrode to measure the electrical activity on the surface of the muscle, and the diameter of the conductive area is between 6-12 mm. The electrodes are made of graphite electrodes or titanium electrodes to prevent accidents in the magnetic field.

Before placing the electrodes of the EMG pick-up device, the skin temperature discoloration paint is applied to the patient's self-reported affected area and extended to the side of the spine. The skin temperature discoloration paint can effectively identify the temperature difference on the body surface, and in the position and surrounding areas that affect blood circulation such as muscle tension and spasm and the healthy side in stark contrast. The skin temperature discoloration paint adopts the binary mixture of palm alcohol and myristyl alcohol as the solvent, and the discoloration range is about 30-44 degrees Celsius by adjusting the ratio of the two and the processing technology, and further at 33 degrees Celsius. Between -40 degrees Celsius. Mark the low temperature points that are significantly lower than the healthy side and the surrounding areas in the above-mentioned areas where the color-changing paint is applied.

Each group of three electrodes is arranged around the marked point as the center. The active and measuring electrodes are connected parallel to the direction of the main muscle fibers at the marked point. The long axis of the electrodes is in the same direction as the muscle fibers, with a distance of 2-2.5cm, and should be avoided as far as possible. On the tendon, the neutral electrode is placed in an electrically neutral position near the above marked point. The healthy side is selected symmetrically, and a set of electrodes is also set.

The EMG signal pickup device is connected with an EMG signal on-site processing device, which realizes filtering and amplification and then performs logical judgment. If the signal obtained in the low-frequency sampling sequence enters the fatigue signal judgment process; if the signal obtained in the high-frequency sampling sequence Then enter the pain signal judgment process. In the above-mentioned EMG signal judgment process, fast Fourier transform is implemented to obtain its MPF value for frequency domain analysis. During the frequency domain analysis, the Matalab analyzer is used to monitor whether the MPF value meets the preset index. For example, if there is a rapid drop or even a flash break (similar to a cliff-like drop), it is instructed to enter the mitigation mode 2-1, otherwise it will enter the relaxation mode 2-2; The self-adaptive neural network learning mode can also be used to make judgments, and the EMG distribution map on both sides of the normal spine can be obtained in combination with laboratory data. Judgment is made after the EMG data/uninhibited side data exceeds the weighting factor.

In the above signal pickup process, the working procedure of the control module is carried out according to the following logic: detect the MEP signal generated by transcranial magnetic stimulation in the target muscle, and determine whether there is damage to the nerve descending conduction link, specifically whether the D wave is correctly detected. ; If there is a link conduction obstacle, any form of mechanical massage is strictly prohibited; if the D wave signal is normal, enter the real-time surface electromyography monitoring process, which is mainly determined by monitoring whether the MPF value in the signal drops rapidly or even flashes. What kind of massage mode can be further combined with MPs signal and monitor the latency time of EMG signal.

In the relief mode 2-1, a static magnetic field with a size of 0.6-0.9T is applied, and it is set in the up and down (or left and right) directions of the massage table; ultrasound is applied to the side of the spine at the indicated position of the skin temperature, and the ultrasound convergence depth is 0.8-2.5cm, The frequency is 0.2-1.0MHz, and the power is 1mW/cm ² ; the ultrasonic transducer used is close to the skin, the effective area of the transducer probe is 10mm×8mm, and the longitudinal direction is perpendicular to the direction of the human spine. Ultrasound forms a converging point with an area of 1 square centimeter in the subcutaneous tissue corresponding to roughly the ganglion, where the cell wall and the charged particles in the cytoplasm in the nerve tissue vibrate, resulting in depolarization of the cell membrane according to the Hall effect. The action potential will be conducted to the corresponding skeletal muscle, causing a slight twitch or tremor. This action potential is emitted by the patient's autologous nerve node, which is highly simulated and adaptable. The magnitude of the induced action potential is nonlinearly related to the ultrasonic frequency. At the same time, the magnitude of the ultrasonic frequency is adaptively changed according to the electromyographic signal obtained by the pick-up electrode, and this feedback method reduces the MPF drop value of the electromyography. Because of the "on-or-no" nature of the depolarization of multiple nerve cell membranes, the above-mentioned nonlinear increase of the evoked potential can be observed clinically, that is, it may appear to change linearly without following the adjustment of the ultrasonic frequency. The adjustment of the ultrasonic frequency by the control module is carried out in units of 0.1KHz, the ultrasonic frequency of each adjustment is maintained for at least one cycle, and the MPF value is detected at periodic intervals.

In relaxation mode 2-2, apply a static magnetic field (to avoid acting on the user's head), the size is 2.5T, which can be set up and down (or left and right) on the massage bed; then select the one with the most obvious temperature change according to the above skin temperature indication The position is taken as the center of the gradient magnetic field action band, and the gradient magnetic field is applied, its size is 100mT, and the switching rate is 10-15mT/m.s (y circle). Under its action, the above-mentioned tissues, including nerves and muscle receptors, have bioelectric effects, resulting in irregular muscle belly shaking that is difficult to detect with the naked eye, which is helpful for blood circulation and lactate metabolism. Generate more or less heat. The heat generated will cause a temperature change in the part where the skin temperature color-changing paint is applied, which will cause the phase change material to absorb heat and liquefy after reaching the threshold of the phase change material contained therein, thereby avoiding thermal damage to the skin. At the same time, the operator can monitor the skin temperature through the color of the thermochromic paint. During the stop period of the gradient magnetic field and the start of the working period of the EMG acquisition module, the above-mentioned phase change material will also act to prevent the temperature of the coating part from being too low, and to prevent the EMG signal caused by the muscle tension of the skin and muscles due to changes in heat and cold. error.

The results of large sample analysis of ECG of patients with different types of cervical spondylosis show that cervical spondylosis and ECG abnormalities have a greater correlation and even the sameness, so it is also called cervical heart syndrome. The bioelectricity generated during the magnetic field stimulation of the peripheral nerve will inevitably partially overlap or even conflict with the ECG signal. Clinical data show that this situation is especially obvious in patients with cervical spondylosis, and the error interval of the ultrasonic magnetic field treatment effect will be significantly increased. If the real-time ECG detection can be further added in the working process of the above-mentioned magnetic therapy module, it will provide a better timing indication for the incision of ultrasonic magnetic therapy.

Holden's research in 2004 showed that the vascular wall will generate a potential difference on the body surface in the static magnetic field, and the induced electric field may affect the propagation of the cardiac action potential (The sensitivity of the heart to static magnetic fields [J]. Progress [J]. Progress in Biophysics & Molecular Biology, 2005, 87(2-3):289_320.). Specifically, for the commonly used three-lead, five-lead, and twelve-lead ECG detection results, the influence of the induced potential of the static magnetic field is mainly reflected in the deformation or delay of the T wave. In static magnetic field therapy, for example, in the mitigation mode 2-1 of the present invention, because the magnetic field strength is small enough to have a significant impact on ECG, it can still be seen that similar adverse potential differences interfere with the therapeutic effect through detection and comparison of experimental results. In order to avoid interference, a reliable grounding, filter and metal cover can be added to the ECG. Furthermore, the ultrasound in the S-wave triggering mode 2-1 can be realized by the electrocardiographic signal through the circuit.

In the process of magnetic field changes in relaxation mode 2-2, the detection of ECG signals is often severely distorted, so how to achieve a better timing of magnetic therapy insertion will be a further technical problem that needs to be solved. The data obtained in the experiment of "The Effect of Abdominal Breathing on Heart Rate" conducted by Hebei Normal University showed that subjectively controlling the rhythm of abdominal breathing helps to control the heart rate at a relatively low and stable level. Similarly, the related research of Xi'an Jiaotong University also shows that heart rate and respiration can interact, and the coupling relationship will not be repeated here. In the present invention, a lower heart rate is obviously beneficial to avoid interference with peripheral nerve bioelectricity; at the same time, in the end-expiration phase of abdominal breathing, there will be a relatively obvious relaxation stage of the respiratory muscles, which can be achieved by the user's conscious Extend to 6-8 seconds. At this time, the gradient magnetic field switching rate in the 2-2 massage mode is controlled to the peak value, which will achieve better results. Therefore, the present invention further provides a breathing indicating device, which can adopt any prompting means such as sound and light in the prior art, such as a buzzer or an LED flashing decoration. It is used to instruct the user to perform the frequency of abdominal breathing, and at the same time, after the user enters a stable breathing state, the gradient magnetic field changes to keep the magnetic field switching frequency synchronized with the exhalation phase of abdominal breathing. Clinical trials have shown that most adults can maintain a breathing rate of 5-7 breaths per minute when abdominal breathing with a breathing indicator device, while the heart rate will drop to a lower heart rate level within its normal range. At this time, the effect of combined magnetic field therapy is significantly improved, and the measured MPF value can be relatively increased by 1%-10% under the same treatment time.

Still further, in the working process of the above-mentioned rehabilitation system, the effect of drug-assisted treatment is increased, which is realized by the drug therapy module, and the purpose is to promote the blood flow in the local position and improve the effect of relieving muscle tension. The medicine is increased or decreased by using the supplementary bone and promoting blood circulation test recipes well known to those skilled in the art. After cooking and purification, the active ingredients are further ground and mixed into the aforementioned skin temperature discoloration paint and applied to the site receiving magnetic therapy. In the process of magnetic stimulation, the above-mentioned drugs penetrate into the skin after being heated to achieve drug effects.

When the D wave conduction is normal, and the indirect wave I wave latency is prolonged (the criterion is roughly 1.5 times the normal duration, note that the MEP signal may have fluctuations in amplitude and latency between single waves, and the control module will wait until it is relatively stable. Computational comparisons) may indicate nerve damage, such as nerve contusion, de-sheathing. Dominant nerve damage often indicates damage to the skeletal muscles and corresponding bones it innervates, especially hidden fractures. Hidden fractures, also known as Hidden Fractures, are often caused by fatigue, hidden trauma, etc. They are not easy to find under normal X-rays and delay the disease, and even cause secondary damage to related nerves. In order to accelerate the healing of fractures, especially hidden fractures, the present invention provides a working mode 2-3 for neuro-osseous injuries.

Specifically, when the I-wave latency reaches 1.5 times the normal duration of resting and muscle relaxation for adults of the same sex, the control module switches the device into neuro-bone injury rehabilitation mode 2-3. Further, in order to improve the accuracy, the same intensity of magnetic stimulation can also be continuously performed. At this time, the three consecutive magnetic stimulations obtained from the electrodes at the target muscle position as described above produce the peak amplitude of the I wave (take the peak-to-peak voltage, in millivolts) and the latency (defined as the time from the start of stimulation to the appearance of the muscle action potential) in the MEP signal, The unit is milliseconds) when the difference between each pair does not exceed 20%, the three MEP wave peak amplitude h1 and latency t1 and other data were recorded separately and weighted and averaged to obtain the average peak amplitude h1 and t1 . The reason is that MEP is easily affected by various factors and fluctuates. For example, the influence of muscle activity, breathing, heartbeat and even psychological factors at the measurement site of the patient may cause changes in its value.

The above average values are respectively compared with the I wave peak amplitude h2 and the latency period t2 obtained from the corresponding positions on the healthy side. The values h2 and t2 obtained from the position on the healthy side are also the average values obtained by the above method. The average calculation, the comparison of the healthy side and the affected side, and the logic analysis are performed by a real-time field-programmed gated logic circuit. At this time, if the comparison result meets condition 1: h1 is less than 85% of h2 (including 85%) and meets condition 2: when t1 is above 150% of t2 , the control module will transfer the entire device to the neuro-bone injury rehabilitation work mode 2-3. Under laboratory conditions, if h1 is less than 90% of h2 , it can be considered that there is damage to the ascending neural pathway at the location of the marker.

In the above working modes 2-3, the electro-acupuncture of the skin electrode is replaced by a hollow micro-needle (the material of the electro-needle is similar to the above, and the commercially available electrode electro-acupuncture can be used for magnetic field operation), and the setting method is the same as the above. Before placing the electrodes, the skin temperature discoloration paint is applied to the patient's self-reported affected area and extended to the side of the spine. The skin temperature discoloration paint can effectively identify the temperature difference on the body surface, and form a clear appearance in and around the position where muscle tension, spasm, etc. affect blood circulation, as well as the healthy side. Compared. The skin temperature discoloration paint adopts the binary mixture of palm alcohol and myristyl alcohol as the solvent, and the discoloration range is about 30-44 degrees Celsius by adjusting the ratio of the two and the processing technology, and further at 33 degrees Celsius. Between -40 degrees Celsius. In the above-mentioned areas where the color-changing paint is applied, there are marked points that are significantly different from the healthy side and the surrounding parts, including both high temperature and low temperature points. Each group of three electrodes is arranged around the marked point as the center. The active and measuring electrodes are connected parallel to the direction of the main muscle fibers at the marked point. The long axis of the electrodes is in the same direction as the muscle fibers, with a distance of 2-2.5cm, and should be avoided as far as possible. On the tendon, the neutral electrode is placed in an electrically neutral position near the above marked point. The healthy side is selected symmetrically, and a set of electrodes is also set.

The sampling frequency of the electrodes is also 300Hz-500Hz, preferably 450Hz. The common mode rejection ratio is greater than 120dB, and the sensitivity is 1μV. The pick-up electrode uses an active surface electrode to measure the electrical activity on the surface of the muscle, and the diameter of the conductive area is between 6-12 mm. The electrodes are made of graphite electrodes or titanium electrodes to prevent accidents in the magnetic field.

The EMG signal pickup device is connected with an EMG signal field processing device, which implements fast Fourier transform after filtering and amplifying to obtain its MPF value for frequency domain analysis. At this time, MPF will have flashes similar to those described in Mitigation Mode 2-1, and the performance will be more intense. In practice, there will be multiple consecutive flashes and signal disappearance.

The content in the above hollow microneedles is a magnetic nanoparticle sphere mixture with magnetic compliance. One of the mixtures uses ferric tetroxide as the magnetic core and coats biodegradable organic materials, such as the magnetic lipid used by Lopera, and the active pharmaceutical ingredient contained in it is the bone morphogenetic protein BMP2 (using commercially available recombinant human bone morphogenetic materials). protein freeze-dried powder), osteoprotegerin OPG and prostaglandin PGe2, the three are collectively called osteogenic in the present invention, and the preparation process is the prior art; the second is a temperature-responsive thermosensitive magnetic nanoparticle ball , the particle is composed of magnetic iron tetroxide nanoparticles and a layer of polyisopropylacrylamide shell wrapped around the magnetic nanoparticles, and the drugs contained therein are the ligands RANKL and RANK of the receptor activator of nuclear factor KB. Insulin growth factor 1, the two are collectively referred to as osteoclast in the present invention. Studies have shown that OPG is similar in structure and space occupation to RANKL, and can successfully inhibit the binding of RANKL to its receptor through competition, thereby inhibiting the activity of osteoclasts and indirectly promoting osteogenesis; while prostaglandin PGe2 is at a lower concentration or with glucocorticoids. (eg cortisone) can promote osteocyte differentiation and osteogenesis when used in combination, while at higher concentrations or in combination with insulin like growth factor 1 (IGF) stimulates bone resorption and bone metabolism (Nakamura H , et al. Localization of OPG on the bone surface and cement lines in rattibia. Histochen Cyto-chem, 2002 50(7):945-953). The tail end of the hollow microneedle is connected to a pressurized valve through an infusion tube to form a drug infusion system, which is managed by a control module.

The above-mentioned low-temperature and high-temperature discoloration regions are both set as target fields, and directional drug delivery is realized by means of an external permanent magnet magnetic field, the magnetic induction intensity is 0.5-0.9T, and the time is longer than 30 minutes. After 30 minutes the permanent magnet was removed and the control module controlled the drug infusion system to release the magnetic nanoparticle sphere mixture. At this time, the control module manages the breathing indication device to prompt the patient to take high-frequency shallow breathing, more than 15 times per minute, to achieve the effect of simulating hyperventilation, and can provide the patient with a short-term oxygen supply if necessary. In the body fluid environment similar to weak alkalosis, the released BMP2 and OPG exert the best effect (experimental results have been confirmed, the mechanism of action needs to be further studied), and promote the growth of nerves and blood vessels in the corresponding position, as well as bone injury, especially recessive bone. wound healing.

It is worth noting that BMP2 is closely related to vascular calcification, especially arterial vascular calcification. Experiments at home and abroad have shown that BMP2 also has a causal relationship with heterotopic ossification (also called HO, Heterotopic osteogenesis). HO often occurs in large joints, such as the hip joint, elbow joint, lumbar spine, cervical spine, etc., and can also occur between muscles. HO causes joint restriction and pain, and the skin temperature of the affected area increases significantly, which may be related to abnormal blood flow and stromal cell differentiation at the lesion. At the same time, clinical observations show that patients with craniocerebral injury and limb fractures frequently have early HO near the lesion with fast blood flow Symptoms, similar locations also have abnormally elevated skin temperature. Combined with bioelectric detection, the prone range of HO can be roughly demarcated. According to the experiment of Jilin China-Japan Friendship Hospital, in the process of craniocerebral trauma combined with limb fracture healing, the reasons for the significant increase in the incidence of HO in patients include: the increase of transforming growth factor TGF, the massive maturation of BMP2, and the inhibition of osteoclast differentiation, etc. . In order to avoid the occurrence of similar ectopic osteogenesis and undesired vascular calcification, the hollow microneedles are mixed with thermosensitive magnetic particle balls containing osteoclasts. When the temperature rises to nearly 40 degrees, the outer coated polymer particles The isopropylacrylamide shell begins to disintegrate, releasing the drug into the interstitial space and subcutaneously into the blood. The temperature increase is mainly achieved by the bone injury module 7, specifically: the bone injury module includes several sets of interference current electrodes and interference current machines. Each set of the electrodes may include commercially available quadruple electrodes (the interference position of the quadruple electrode is located below the center of its own geometric center) or general electrodes (the interference position of the general electrode is located below the intersection point of the two groups of electrodes), The selection is made according to the area of the implementation site; electrodes are set at the high-temperature calibration position where the skin temperature is discolored, and the crossover depth is about 2-5 cm, depending on the different positions of the limbs or torso. Frequency 10Hz, 9-22mA interference current. In addition to promoting vasodilation, lymphatic return and local warming in the vicinity of the affected area, the current also contributes to the site-specific release of osteoclasts in the thermosensitive magnetic particle spheres. Osteogenic and osteoclasts are released in the blood and tissue fluid near the high-temperature location marked by the skin temperature discoloration paint, because of the ligand competition and the combined effect of PGe2 and IGF1 to avoid heterotopic ossification and intravascular calcification at the lesion; Instead, it promotes osteoblast differentiation and function in locations where nerve and bone damage may exist.

The above-mentioned interference current machine also leads to a multi-channel interference circuit, which is used to interfere with specific sympathetic ganglia, such as stellate ganglion, thoracic ganglion, lumbar ganglion, sacral ganglion and so on. The interference electrode is set in the same manner as before, using common electrodes, those skilled in the art know the normal physiological position and approximate depth of the ganglion, and set the interference current difference frequency at about 100Hz, and the intensity is 10mA. At present, there are many studies on the stellate ganglion, and the treatment of various neurological diseases by injection of stellate ganglion block has been well known by the majority of medical workers. However, this operation has certain risks, and also has strong technical requirements for the operator. Experiments by the inventor and several collaborating departments of the school have proved that the method of interfering with the ganglion by interfering with the current can simulate the state of denervation. A weakened state of central control of sympathetic nerves in cranial trauma. The above-mentioned state of weakened control has positive effects on bone healing and vascular regeneration, which has been confirmed by clinical trials (Yasuhara T, Shingo T, Date I. The potential role of vascular endothelial growth factor in the central nervous system[J]. Rev Neurosci 2004; 15 (4):293-307.). Under the above simulated denervation state, the effect of neurotrophic factors on target cells in bone tissue and the expression of callus collagen were significantly improved. The current research suggests that the mechanism of action is the high expression of local catecholamines and epinephrine and the increase of chondrocyte activity at the site of bone injury.

The above-mentioned interference to the ganglion can selectively interfere and shield the innervating and ascending nerves at the injury site, thereby inducing cranial reflexes, thereby achieving: on the one hand, it can directly improve the cell targeting receptors in the nerve, muscle and skeletal tissue at the injury site. On the other hand, it simulates the denervation state to induce the brain to secrete more autologous nerve growth factor and calcitonin gene peptide, etc., which has a stronger effect on promoting bone healing. Injectable mouse-derived nerve growth factor is now available.

Detailed ways

The spinal rehabilitation system includes a physiotherapy table 31 for carrying a user, and the table is provided with an opening corresponding to the head and face of the person to facilitate the user to lie down and breathe. The bench is made of non-metallic materials to avoid affecting the effect of electromagnetic therapy, and there are four supporting columns with rollers below. A ring-shaped fence 32 is arranged around the stand 31 , and there is a movable rail on the fence corresponding to the user's foot, and the whole fence has a mouth shape with one end openable and closed. A support arm 321 is provided on the fence 32 corresponding to the user's head, and a plurality of support arms 322 are provided on the side of the fence corresponding to the user's trunk. The support arm can be rotated at multiple angles, bent and can slide on the fence to suit different positions. The material of the support arm is non-metal, and the end of the support arm is provided with a fixed seat 323 . An ultrasonic probe, an infrared probe, a gradient magnetic field coil, a permanent magnet, an electrode and the like are detachably connected to the fixing base of the above-mentioned support arm. A static magnetic field generator 324 is provided on the left side of the fence, which realizes providing a static magnetic field to the user's torso on the stand 31 . The size is specifically 0.6-0.9T, which is realized by a steady and controllable current, and various common technologies in the field can be used. A magnetic shielding plate 325 is provided at the fence corresponding to the position of the user's head. The shielding plate 325 is made of a ferromagnetic material with high magnetic permeability, such as silicon steel, which can be slidably adjusted along the fence, and has a thickness of 1-5mm. After sliding to the proper position, it can be folded to cover the user's head to effectively prevent the user's head from receiving unnecessary magnetic field stimulation.

A flat circular or figure-eight coil 21 is detachably fixed on the fixing seat of the above-mentioned support arm 321 , which can be an iron core coil or a combined coil. The diameter of the coil is between 9-20cm, preferably 12-15cm, and the peak value of the generated magnetic field is not less than 1T. During the transcranial magnetic stimulation, the distance between the center of the coil and the top of the user's head is less than 3.5cm by adjusting the support arm. The frequency of the magnetic field generated by the time-varying current only needs to be greater than 1 Hz, and the coil wire is connected to the control module through the fixed seat on the support arm 321 . During the transcranial magnetic stimulation stage, an anode electrode 11 is arranged at the belly of the target muscle of the user's back or limbs, and a cathode electrode 12 is arranged at the lower portion of the nerve innervating the target muscle and adjacent to the tendon. The electrodes are made of graphite electrodes, and the distance between them is more than 35mm. The selected muscles include but are not limited to deltoid, biceps, triceps, biceps femoris, etc. The use of smaller electrodes can even monitor the current situation of the delicate muscles of the hand. A transcranial magnetic stimulation cycle can be manually set by the control module, generally between 120s-600s. The signals collected by the above two electrodes are transmitted to the control module, and analyzed after filtering, shaping, and amplification as follows: 1. When the received first single-phase positive D wave is blocked, the control module will issue an alarm to remind the operator to The user cannot perform any form of mechanical massage and stop further transcranial magnetic stimulation; 2. When the D wave conduction is normal, and the I wave latency does not reach 1.5 times the normal time, it will automatically enter the working mode 2-1 or 2-2; 3. When the D wave conduction is normal, and the indirect wave I wave latency is longer than 1.5 times the normal duration, the control module controls the entire device to enter the working mode 2-3.

After entering any of the above working modes, the control module stops the continuous transcranial magnetic stimulation, and drives the EMG detection module 1 to pick up the surface EMG signal instead. The pick-up position of the surface EMG signal is a marking point, and the selection of the marking point can be based on the user's self-report, and further use the skin temperature color-changing paint for precise positioning. The specific method is as follows: select palm alcohol, myristyl alcohol, leuco agent and color developing agent as raw materials, wherein the color developing agent can be selected from the heat-sensitive dye crystal violet lactone CVL, the color developing agent can be selected from diphenol-based propane BPA, two alcohols Exist as solvent and compound. The solvent and solute were poured into a vessel heated in a water bath and stirred for a sufficient hour to obtain the formulation. Its discoloration performance depends on the mass ratio of the four substances. When the mass ratio of CVL:BPA:myristyl alcohol:palmitol is 1:3.3:41:22, the melting point of the compound is the lowest, and it is between 33-40 degrees Celsius Has good discoloration properties. The above compound is uniformly mixed with common phase change materials, and the phase change material can be selected from paraffin, etc., and the phase change temperature is about 40 degrees through simple mixing and processing. The mixed phase change material and the above-mentioned compound are applied to the affected area and the corresponding position on the healthy side as reported by the user. After standing for 3 minutes, observe whether there is obvious skin temperature discoloration, and mark the position that is obviously different from the surrounding skin or obviously different from the healthy side.

The surface EMG signal pickup electrodes are arranged around the marked point, a group of three electrodes 13 in which the neutral electrode is placed at the electrical neutral position closest to the marked point, and the active measurement electrode ensures that its connection line is parallel to the main point at the marked point. The direction of the muscle fibers; the long axis of the electrode itself is in the same direction as the main muscle fibers, and the two electrodes are separated by 2-2.5cm. At this time, try not to place them on the tendon. A set of electrodes 14 are also placed symmetrically on the healthy side. The sampling frequency of the electrodes for detecting pain signals is 300Hz-500Hz, preferably 450Hz; the sampling frequency of the fatigue signal detection electrodes is 8-300Hz, preferably 20-100Hz, more preferably 50Hz. The common mode rejection ratio is greater than 120dB, and the sensitivity is 1μV. The pick-up electrode uses an active surface electrode to measure the electrical activity on the surface of the muscle, and the diameter of the conductive area is between 6-12 mm. Electrodes use graphite electrodes or titanium electrodes. The electrode sampling frequency in operating modes 2-3 is the same as that used to detect pain signals.

A marker point is used as an example for description: the wires drawn from the marker point on the affected side and the two groups of electrodes set on the corresponding healthy side are respectively filtered and amplified to realize fast Fourier transform to obtain the MPF value. After that, the two sets of data respectively enter the logic judgment unit 41 of the control module. The ipsilateral signal obtained in the high-frequency sampling sequence enters the pain signal judgment process, while the ipsilateral signal obtained in the low-frequency sampling sequence enters the low-frequency judgment process. In each judgment process, the Matalab analyzer 42 of the control module performs frequency domain analysis on it. First, it is judged whether the MPF value obtained in the high-frequency sampling sequence has a rapid drop or flash phenomenon, and the judgment standard is to measure the corresponding median frequency. Whether the slope (MPs) is significantly increased, the normal range of the slope value should be preset with reference to the user's age, body fat, weight, and the corresponding signals of the healthy side, and can also be obtained by adaptive learning from multiple experiments of the user. Generally, if the MPs value is greater than or equal to 60%, it can be considered that the user's affected muscles need to be relieved by physiotherapy, and enter the process 2-1. If the MPF value obtained in the high-frequency sampling sequence does not show the above-mentioned rapid decline, the analyzer 42 further analyzes the MPF value obtained by the low-frequency sampling of the affected area, and performs analysis and comparison according to the above steps. At this time, the MPs value is greater than 45% and combined with the latency time of the collected EMG signals, it can be determined that the user needs to perform physical therapy relaxation, and enter the process 2-2.

In mode 2-1, the control module activates the static magnetic field generator 324 to apply a static magnetic field, and a static magnetic field with a size of 0.6-0.9 T is applied to the user's torso, especially the spine; ultrasonic waves are set 5-10 cm above the marked point to the side of the spine Action area: Ultrasound is applied through an ultrasonic probe, the ultrasonic concentration depth is 0.8-2.5cm, the frequency is 0.3-1.0MHz, and the power is 1mW/cm ² ; the transducer of the ultrasonic probe used is close to the skin, and the effective area of the transducer is 10mm×8mm , the longitudinal direction is perpendicular to the direction of the human spine. Ultrasound forms a converging point with an area of 1 square centimeter in the subcutaneous tissue corresponding to roughly the ganglion, where the cell wall and the charged particles in the cytoplasm in the nerve tissue vibrate, resulting in depolarization of the cell membrane according to the Hall effect. The action potential will be conducted to the corresponding skeletal muscle, causing a slight twitch or tremor. At the same time, the ultrasonic frequency and intensity are adaptively adjusted according to the EMG signals obtained by the aforementioned surface EMG pick-up electrodes, and this feedback method reduces the MPF drop value of the EMG or in other words "increases" the MPs value. Every working cycle, the control module stops the magnetic field function and enters the surface EMG signal acquisition sequence. After working mode 2-1, the high-frequency sampling sequence is entered, and the above steps are repeated again for the picked-up skin surface EMG signal. Until the measured MPF or MPs value reaches the preset standard or reaches the predetermined time.

In mode 2-2, apply a static magnetic field (to avoid acting on the user's head), the size is 2.5T, which can be set in the left and right directions of the massage bed; then select the position with the most obvious temperature change as the gradient magnetic field according to the above skin temperature indication With the center of the band, a gradient field is applied with a magnitude of 100mT and a switching rate of 10-15mT/m.s (y-circle). The gradient coil is arranged on one of the aforementioned support arms.

Under the action of the gradient magnetic field, the above-mentioned tissues including nerves and muscle receptors generate bioelectric effects, thereby realizing muscle belly shaking in an irregular form that is difficult to detect with the naked eye. Clinical experiments have shown that this not only promotes blood circulation and lactate metabolism, but also helps the fatigue recovery of the corresponding neural pathways, and at the same time generates more or less heat according to the switching rate of the gradient magnetic field. The heat generated will cause a temperature change in the part where the skin temperature color-changing paint is applied, which will cause the phase change material to absorb heat and liquefy after reaching the threshold of the phase change material contained therein, thereby avoiding thermal damage to the skin. At the same time, the operator can monitor the skin temperature through the color of the thermochromic paint. During the stop period of the gradient magnetic field and the start of the working period of the EMG acquisition module, the phase change material will also undergo a phase change to release heat to prevent the temperature of the coating part from being too low, and prevent the skin and muscles from being caused by muscle tension caused by changes in heat and cold. EMG signal error. The magnitude of the gradient magnetic field switching rate changes adaptively with the EMG signal obtained by the aforementioned pick-up electrode, and this feedback method reduces the MPF drop value of EMG or in other words "increases" the MPs value. Every working cycle, the control module stops the magnetic field function and enters the surface EMG signal acquisition sequence. The difference is that the low-frequency sampling sequence is entered after working mode 2-2, and the picked-up signal repeats the above steps again until the MPF or MPs value reaches the preset standard.

Wherein, the gradient magnetic field coil is provided by a figure-eight coil on the aforementioned support arm fixing seat, the upper half of the coil is fixed on the fixing seat, and the lower half of the 0 is arranged under the aforementioned stand. The upper and lower coils are formed relative to each other, and the entire coil can follow the support arm to move back and forth to adapt to changes in different positions.

Further, infrared skin temperature monitoring probes can be added to prevent burns. The infrared thermometer can be realized by using common technologies in the art, and its monitoring range is between 30-45 degrees Celsius. The detection head is mounted on the aforementioned support arm fixing seat and is electrically connected with the control module. By presetting the warning temperature in the control module, such as 41 degrees Celsius (the specific selection of the phase change material needs to be considered here), the temperature warning of the monitoring area is realized to prevent burns or accidents.

Further, in order to avoid the interaction between the electric potential field generated by the static magnetic field on the blood vessel wall and the electrocardiographic action potential in mode 2-1, an electrocardiographic detector 61 may be introduced. It uses common three-lead, five-lead or twelve-lead methods to detect the user's ECG. In order to avoid interference, the ECG detector 61 is protected by means of reliable grounding, a filter, and a metal jacket. The detection trigger circuit can also be used to realize the start of ECG S-wave-triggered ultrasound. That is to say, a corresponding circuit is added to the ECG detector: the ECG signal detection circuit 62 realizes the amplification of the ECG signal, the signal frequency band is 1-2KHz, and the amplification factor can be adjusted; the S wave detection circuit 63 is composed of a follower and a QRS filter. , rectifier circuit, peak hold and comparator. The ECG output signal is converted into a voltage signal and then input to the monostable trigger to detect the S wave and obtain the S wave synchronization pulse signal. The drive circuit is triggered on the rising edge of the S wave to realize the startup of the ultrasonic signal. Based on the trigger circuit, the R-wave effect of the cardiac action potential is avoided, thereby reducing the mutual influence between the two. Further, the trigger circuit is not directly connected to the start-up circuit but is connected to the start-up circuit through the control module. At this time, after obtaining the rising edge trigger signal, the control module temporarily stores the signal, and starts the ultrasonic signal only after obtaining the next trigger signal; the above temporary storage behavior can effectively reduce the refractory period response of peripheral nerves and increase the effective duration of treatment. According to the actual effect, it can be further set to temporarily store two or more trigger signals before waiting for an opportunity to drive the ultrasonic circuit to work.

Further in order to achieve a better magnetic therapy cut-in timing issue in Mode 2-2. Add a buzzer or similar warning means to the fence near the user's head. The buzzer is electrically connected to and managed by the control module, and is used to instruct the user to perform abdominal breathing. At the same time, after the user enters a stable breathing state, it cooperates with the change of the gradient magnetic field to switch the frequency of the magnetic field to the exhalation of abdominal breathing. The gas phase is kept in sync. Specifically, the buzzer sounds to prompt the user to inhale, and the control module controls the switching rate of the gradient magnetic field coil to keep at least 80% of its peak value between the buzzer sounds for 3s-6s. Clinical trials have shown that most adults can maintain a breathing rate of 5-7 breaths per minute when abdominal breathing with a breathing indicator device, while the heart rate will drop to a lower heart rate level within its normal range. At this time, the effect of combined magnetic field therapy is significantly improved, and the measured MPF value can be relatively increased by 1%-10% under the same treatment time.

Still further, in the working process of the above-mentioned rehabilitation system, the effect of drug-assisted treatment is increased, which is realized by the drug therapy module, and the purpose is to promote the blood flow in the local position and improve the effect of relieving muscle tension. The medicine is increased or decreased by using the supplementary bone and promoting blood circulation test recipes well known to those skilled in the art. After cooking and purification, the active ingredients are further ground and mixed into the aforementioned skin temperature discoloration paint and applied to the site receiving magnetic therapy. In the process of magnetic stimulation, the above-mentioned drugs penetrate into the skin after being heated to achieve drug effects. The specific drug components are as follows (mass ratio): Epimedium 5, Drynaria 21, Achyranthes 6, Safflower 1, Fangfeng 9, Musk 1, Mountain Lacquer 2, Xueji 11, Psoralea 3, Amber 4, Chuanxiong 10, Qiang live 2. The medicinal ingredient can also be applied to the affected area alone after removing the skin temperature discoloration paint, and the temperature monitoring is completely completed by the aforementioned infrared probe. During use, a hydrogel dressing can also be added; the above-mentioned drug coating is evenly coated in the medical sterile transparent hydrogel dressing layer; the dressing layer is tailored to a specific shape and laid on the main muscle groups on both sides of the spine, such as the erector ridge. Muscles, multifidus, etc., are not limited to specific magnetic therapy positions; at the same time, after coating, it needs to cooperate with the mechanical pulling effect of the corresponding muscle group, which is achieved by adding upper limb mechanical pulling rods; the pulling rods are installed on the massage platform for use The height of the user's head is slightly higher than the back of the prone user; the pulling direction is parallel to the platform, and the direction of the force is away from the human body to achieve pulling on the user's upper limb; the pulling is controlled by the control module, and the frequency is Between 5-15 times a minute. Further, the stretching can be matched with the abdominal breathing rate. Specifically, the buzzer sounds to prompt the user to perform stretching after breathing, and the stretching lasts for 4-8 seconds and then relaxes; the user uses the disappearance of the pulling force as an exhalation instruction.

In the neuro-bone injury rehabilitation working mode 2-3, an interference current machine 71 is accommodated under the physiotherapy bench 31, which is connected to a plurality of interference electrodes 711 through wires; the interference electrodes 711 can be arranged on the support arm 322 for easy movement to correspond to different ganglia; a pressurized valve 72 is also accommodated under the physiotherapy bench, which is connected to a plurality of hollow microneedle electrodes 722 as surface EMG signal pickup electrodes through an infusion tube 721; a group of three hollow microneedle electrodes, The neutral electrode is placed at the electrically neutral position closest to the marked point, and the two active measurement electrodes ensure that their connection lines are parallel to the direction of the main muscle fibers at the marked point; the long axis of the electrode itself is in the same direction as the main muscle fibers, and the two active electrodes 2-2.5cm apart. A set of hollow microneedle electrodes were also placed symmetrically on the unaffected side. The sampling frequency is 300Hz-500Hz, preferably 450Hz, the common mode rejection ratio is greater than 120dB, and the sensitivity is 1μV. The pick-up electrode uses an active surface electrode to measure the electrical activity on the surface of the muscle, and the diameter of the conductive area is between 6-10 mm. Electrodes use graphite electrodes or titanium electrodes.

Further, the tail end of the hollow microneedle is connected to the pressurized valve mechanism through the infusion tube to realize controllable drug infusion, and the healthy side does not carry out drug infusion. The pressurized valve and microneedle contain a magnetically compliant magnetic nanoparticle sphere mixture. One of the mixtures uses ferric tetroxide as the magnetic core and coats biodegradable organic materials, such as the magnetic lipid used by Lopera, and the active pharmaceutical ingredient contained in it is the bone morphogenetic protein BMP2 (using commercially available recombinant human bone morphogenetic materials). Protein freeze-dried powder), osteoprotegerin OPG and prostaglandin PGe2, the three are collectively called osteogenic in the present invention, and the preparation process is the prior art; The microparticles are composed of magnetic ferric oxide nanoparticles and a layer of polyisopropylacrylamide shell wrapped around the magnetic nanoparticles, and the drugs contained therein are the ligands of the receptor activator RANK of nuclear factor KB, RANKL and insulin growth. Factor 1, in the present invention, the two are collectively referred to as osteoclast. The above marked point area is set as the target field, and the magnetic field setting of the marked point is realized by adding a permanent magnet, the magnetic induction intensity is 0.5-0.9T, and the time is more than 30 minutes. The selection of the permanent magnet is the prior art in the field, the unipolar cylindrical shape, and the radius of the section circle is 1.5-4 cm. It is provided on the support arm 322 and is positioned 3-8 cm above the marked point by means of the adjustable support arm. The permanent magnet 326 not only provides a targeted magnetic field environment, the prior art also shows that it is beneficial to the healing of hidden bone injuries. The control module controlled the drug infusion to release the magnetic nanoparticle sphere mixture 30 minutes after the targeted magnetic field was applied to the marked spot. At this time, the breathing indication device managed by the control module prompts the patient to take high-frequency shallow breathing, more than 15 times per minute, to achieve the effect of simulating hyperventilation, and can provide the patient with a short-term oxygen supply if necessary. Indication methods can also use buzzer or LED flash decoration and so on.

While the patient is breathing as instructed, the control module controls the operation of the bone injury module 7 . The bone injury module includes an interference current electrode and an interference current machine; the electrodes include commercially available quadruple electrodes (the interference position of the quadruple electrode is located below the middle) or general electrodes (the interference position of the general electrode is located in two groups of electrodes. Below the cross-connection point) can be selected according to the area of the implementation site; calibrate the electrode at the high-temperature calibration position where the skin temperature changes, try to avoid the aforementioned surface EMG signal pickup electrode in space, and the cross depth is about 2-5 cm. Depending on the different positions of the limbs or torso, the specific choice is made; the intermediate frequency current is used, specifically the 4.5kHz current, and the interference current of the difference frequency of 10Hz and 9-22mA is generated at the interference position. In addition to promoting vasodilation, lymphatic return and local warming in the vicinity of the affected area, the current also contributes to the site-specific release of osteoclasts in the thermosensitive magnetic particle spheres. When the temperature rises to nearly 40 degrees, the outer covering of the polyisopropylacrylamide shell begins to disintegrate, and the drug is released into the interstitial space and subcutaneously into the blood. Heterotopic ossification and intravascular calcification at the lesions are avoided because of ligand competition and the combined effect of PGe2 and IGF1, while the differentiation and function of osteoblasts are promoted in the position where nerve and bone damage may exist. At the moment when it reaches close to 40 degrees, the skin temperature discoloration coating begins to undergo a phase transition to avoid excessive temperature and excessive release of osteoclasts.

The above-mentioned interference current machine also leads to a multi-channel interference circuit, which is used to interfere with specific sympathetic ganglia, such as but not limited to stellate ganglion, thoracic ganglion, lumbar ganglion, sacral ganglion, and the like. The interfering electrodes are arranged in the same manner as before, using common electrodes, the electrode wires intersect, and the intersecting point corresponds to the position of the ganglion, and those skilled in the art are familiar with its proper depth. The difference frequency of the interference current generated by the intermediate frequency current at the interference position is about 100Hz, and the intensity is 10mA. Interfering current inhibits the excitation of the corresponding ganglion, has the effect of ganglion block, and can effectively promote the activity of osteoclast and osteogenic protein. When the effective ganglion is blocked, the MPF signal obtained by the EMG electrode at the high temperature marked point will increase significantly, and the increase can generally reach more than 12% of the initial measured MPF value, which is also the definition of effective ganglion in the present invention. method. In the present invention, the so-called effective ganglion may include the ganglion of the innervation nerve of the muscle where the marker point is located, such as the direct innervation ganglion and other ganglia that may exist on the path from the center to the directly innervation ganglion. Fast and accurate ganglion interference block for different target muscles requires the operator to have extensive experience and anatomical knowledge; at the same time, due to the complexity and susceptibility of the nervous system to interference, effective ganglia may be blocked due to excessive stimulation or patient muscle tension Degeneration of the effect, also known as facilitation of the ganglia. Based on this, the present invention designs a cyclic ganglion interference method, taking the interference electrodes with n ganglions as an example (n generally ranges from 3 to 6, too many interference electrodes will easily cause the total duration of the interference cycle) If it is too long, it will affect the final rehabilitation effect): in each period from the 1st to the nth interference period, the preset n ganglion interference electrodes are activated in turn; in the n+1th interference period, only the effective ganglion is activated. (maybe more than one); in each cycle from the n+2th to the 2n+1th cycle, the preset n ganglion interference electrodes are turned on in turn; and so on, until the preset time ends. An EMG signal pickup period is inserted after the end of each ganglion interference period, and at the end of the EMG signal pickup period, whether it is an effective ganglion interference electrode is determined according to the increase in MPF. If a valid ganglion cannot be determined in a round, then no ganglia will be disturbed in the valid ganglion interference period of the round, preventing excessive facilitation. The start of the interference period is based on the moment when the permanent magnet is removed, and the total duration is generally set to be no more than 30 minutes. If necessary, after 30 minutes, a permanent magnet can be applied again at the marked point for 30 minutes, and the duration of the disturbance period is set to 30 minutes as the next cycle. The above-mentioned interference current machine can control the interference electrode of the affected part and the ganglion interference electrode to work synchronously, so as to achieve the synchronization of the release of osteoblasts, osteoclasts and denervation in the affected part.

Because of the characteristics of occult fractures, patients often do not have typical injury symptoms clinically, but show local muscle tension and spasm, and patients are often not aware of it at the first time. Different from the rehabilitation treatment of typical bone injuries, patients with occult fractures, especially old occult fractures, often have a large number of callus and fibrous scars in the affected area, and may even be accompanied by muscle atrophy. Because the muscles have insufficient feedback to nerve conduction, the ganglia that innervate the affected muscles tend to overfire. At this time, we should not blindly promote bone, but should first promote the blood circulation of the affected area, improve muscle tension, restore the normal bioelectrical level and physiological environment of the affected area, and at the same time give the necessary interference to the over-discharged ganglia and the injection of the magnetic nanoparticle sphere mixture in the affected area. Therefore, in the present invention, after the above-mentioned working modes 2-3 are executed for a period of time, the control module controls the entire system again to enter a new round of working cycles: transcranial magnetic stimulation is performed, and the electromyography detection module detects motor evoked potentials MEP and MEP. Surface EMG signals were detected.

When the I-wave delay obtained in this round of induction does not exceed 1.2 times the normal duration of resting and muscle relaxation for adults of the same sex, there is no need to determine whether the MPF value drops rapidly or flashes, and directly enters the following working mode: In this working mode, the set working time is not less than 30 minutes, and the patient is guided through abdominal breathing through the breathing indication device; the control module activates the static magnetic field generator 324 to apply a static magnetic field, and a static magnetic field with a size of 0.6-0.9 T is applied to the user. Trunk; set the ultrasonic action area at 5-10cm from the side of the spine on the marked point; the control module controls the ultrasonic probe to apply ultrasonic waves, the ultrasonic convergence depth is 0.8-2.5cm, the frequency is 0.3-1.0MHz, and the power is 1mW/cm ² ; the ultrasonic probe used The transducer is close to the skin, the effective area of the transducer is 10mm×8mm, and the longitudinal direction is perpendicular to the direction of the human spine; the ultrasonic frequency and intensity are adaptively adjusted with the EMG signal obtained by the aforementioned surface EMG pick-up electrode. The electric MPF drop value decreases or in other words makes the MPs value "increase"; the control module simultaneously controls the interference current machine to start the ganglion interference electrode to interfere with multiple specific ganglia, and the pressure valve simultaneously delivers the hollow microneedle electrode during interference Magnetic nanoparticle sphere mixture; the interference to ganglia can also choose the way of cyclic ganglion interference, and the selection of ganglia includes but is not limited to stellate, thoracic, lumbar, sacral ganglia and the like. For the convenience of description, the above working mode is named as occult fracture rehabilitation mode 2-4.

Further, in the occult fracture rehabilitation mode 2-4, in order to avoid the interaction between the electric potential field generated by the static magnetic field on the blood vessel wall and the electrocardiographic action potential, an electrocardiogram detector 61 is used. It uses common three-lead, five-lead or twelve-lead methods to detect the user's ECG. In order to avoid interference, the ECG detector 61 is protected by means of reliable grounding, a filter, and a metal jacket. The detection trigger circuit can also be used to realize the start of ECG S-wave-triggered ultrasound. That is to say, a corresponding circuit is added to the ECG detector: the ECG signal detection circuit 62 realizes the amplification of the ECG signal, the signal frequency band is 1-2KHz, and the amplification factor can be adjusted; the S wave detection circuit 63 is composed of a follower and a QRS filter. , rectifier circuit, peak hold and comparator. The ECG output signal is converted into a voltage signal and then input to the monostable trigger to detect the S wave and obtain the S wave synchronization pulse signal. The drive circuit is triggered on the rising edge of the S wave to realize the startup of the ultrasonic signal. Based on the trigger circuit, the R-wave effect of the cardiac action potential is avoided, thereby reducing the mutual influence between the two. Further, the trigger circuit is not directly connected to the start-up circuit but is connected to the start-up circuit through the control module. At this time, after obtaining the rising edge trigger signal, the control module temporarily stores the signal, and starts the ultrasonic signal only after obtaining the next trigger signal; the above temporary storage behavior can effectively reduce the refractory period response of peripheral nerves and increase the effective duration of treatment. According to the actual effect, it can be further set to temporarily store two or more trigger signals before waiting for an opportunity to drive the ultrasonic circuit to work.

Further, infrared skin temperature monitoring probes can be added to prevent burns. The infrared thermometer can be realized by using common technologies in the art, and its monitoring range is between 30-45 degrees Celsius. The detection head is mounted on the aforementioned support arm fixing seat and is electrically connected with the control module. By presetting the warning temperature in the control module, such as 41 degrees Celsius (the specific selection of the phase change material needs to be considered here), the temperature warning of the monitoring area is realized to prevent burns or accidents.

The aforementioned control module can be realized by using a common single chip computer, a field programmable gate control circuit or a microcomputer, etc. in the field, and a small keyboard or a conventional keyboard can be used as an input device.

The above embodiments are only used for explaining the technical solutions of the present invention, and should not be used as a limitation to understand the protection scope thereof. Any improvement or modification made by those skilled in the art on the basis of the present invention without departing from the concept of the present invention does not depart from the protection scope of the present invention.

Claims (2)

1. the spine recovering system that multiple means combine, the system comprises:

Checking with EMG method module 1, magnetic therapy module 2, massage module 3, control module 4, display module 5, ECG module 6 and bone fracture mould Block 7 etc.；The wherein checking with EMG method module real-time detection human body surface myoelectric, and classified according to myoelectricity level and feature； The control module is judged that the conduction of D wave is normal in the deterministic process according to the classification results that checking with EMG method module is sent When, if indirect wave I wave incubation period reaches control module control whole device on 1.5 times of ordinary duration and enters neural bone fracture health Complex pattern 2-3, in which:

Using the magnetic nano particle bulbec mixture with magnetic compliance, it includes osteogenins and osteoclastic element；The magnetic Nano Particle ball mixture is placed in pressurizing valve, and pressurizing valve is connected with the micropin tail end of empty micropin electrode, is managed by control module；? Targeting is over-the-counter plus after permanent magnet 30 minutes or more, pressurization injection magnetic nano particle bulbec mixture；Then control module management is exhaled Instruction device prompt patient's progress high frequency shallow breathing is inhaled to reach 15 times per minute or more；Meanwhile several sets interference of bone fracture module 7 Electrode starts to carry out current interference；Interference position includes the High temperature calibration position and specific sympathetic ganglion that skin temperature changes colour；

After operating mode 2-3 executes completion a cycle duration, control module controls whole system again and enters a new wheel work It recycles: executing transcranial magnetic stimulation, checking with EMG method module detects Motion Evoked Potential MEP and surface electromyogram signal；When When the I wave delay that epicycle induces does not reach same gender adult tranquillization, state of flaccid muscles on 1.2 times of ordinary duration When be directly entered occult bone fracture rehabilitation modality 2-4；

It is characterized by: in operating mode 2-4 set work time-histories be no less than 30 minutes and by breathing instruction device it is complete Journey guides patient's abdominal respiration；Control module starts magnetostatic field generator 324 and applies magnetostatic field, the magnetostatic field of size 0.6-0.9T It is applied to user's trunk；Setting region of insonation at the 5-10cm of backbone side is traced back in mark point；Control module control ultrasound Probe applies ultrasound, ultrasound convergence the depth 0.8-2.5cm, frequency 0.3-1.0MHz, power 1mW/cm²；Ultrasound used is visited The energy converter of head is close to skin, and energy converter effective area 10mm × 8mm is longitudinally perpendicular in human spine direction；Supersonic frequency and Intensity is made adaptability with the electromyography signal that aforementioned surfaces myoelectricity pickoff electrode obtains and is adjusted, which makes myoelectricity MPF drop-out value reduces or in other words makes MPs value " raising "；Control module controls the starting neuromere interference of interference electric current machine simultaneously Electrode is to multiple specific ganglionic interference, and pressurizing valve is mixed to empty micropin electrode conveying magnetic nano particle bulbec while interference Close object；Rotation neuromere conflicting mode equally can choose to ganglionic interference, ganglionic choose includes but is not limited to star Shape, chest, waist, sacral ganglia etc..

2. spine recovering system according to claim 1, it is characterised in that: the breathing instruction device is buzzer, electricity It connects control device and is managed by it, for instructing user to carry out the frequency of abdominal respiration；Buzzer prompt of sounding makes User's air-breathing, user exhales after buzzer sounds 3s-6s；The time interval that the buzzer sounds ensures that user keeps 5-7 breathing per minute.