CN1092516C - Preparation for epidermis and process for its preparation - Google Patents

Abstract

The invention provides a epidermis preparation and preparation method thereof. The preparation for epidermis containing kojic acid and/or its derivative, which has improved preparation stability and which shows lasting effectiveness, is provided. The improved preparation stability is imparted by adding to the preparation at least one member selected from the group consisting of fatty acid esters and fatty acid glycerides.

Description

Epidermis preparation and its preparation method

The present invention relates to a kind of epidermis preparation, and the preparation method of this preparation, said preparation contains kojic acid and/or its derivant, UV absorbent, it also contains a kind of material that is selected from hydrocarbon, lipid and sclerosis or unhardened fat and oil at least, and it is permanent that this material is used to strengthen the stability of kojic acid and/or its derivant and its usefulness is continued.

The form of epidermis preparation has two kinds usually: O/W Emulsion (oil-in-water) and W/O (Water-In-Oil), it is different that their water and the different and physical property of ratio of oil have, still, and by means of surfactant, emulsifying stably and dispersion oil phase or water, thus two kinds of preparations are uniform preparation.

Kojic acid and its derivant inventor were carried out long term studies, they are known useful reagent with various excellent properties, following document all has report: Japanese unexamined patent publication No. publication number 55-157509, Japan unexamined patent publication number S56-18569, S58-22151, S58-22152, S58-34446, S60-7961, S60-9722 and S60-10005, Japanese unexamined patent publication No. publication number S60-137253, Japan unexamined patent publication number S61-10447 and S61-60801, publication number S62-5909 in the careful patent of day ins and outs, Japanese unexamined patent publication number S62-3820 and S63-27322, Japanese unexamined patent publication No. publication number H1-132502 and Japanese unexamined patent publication number H5-30422.

But kojic acid and its derivant (the following kojic acid that is referred to as again sometimes) also are the relatively poor reagent of known self stability.Particularly, when kojic acid is impregnated in above-mentioned O/W Emulsion or the W/O Emulsion, need suitable complicated technology to design a kind of suitable prescription.Therefore, the preparation that contains kojic acid for preparation, urgent task is the following a kind of technology of development: this technology can make the preparation that contains kojic acid have enough stability tolerating serious distribution mechanism, and does not have into unhappy sensation in the time will agreeing put on the skin.

When in various epidermis preparations, containing kojic acid, these preparations are placed in and may be exposed to ultraviolet condition to denaturation degrees, being subjected to ultraviolet may be the external cause of its variable color or decomposition, therefore, deducibility goes out to mix a kind of an amount of UV absorbent and suppresses the infringement of being hanked by ultraviolet radiation.

For example: following document has provided corresponding example, Japanese unexamined patent publication No. publication number S62-108804 and S64-83008, Japanese unexamined patent publication number H4-46924.

There is solubility problem in these UV absorbent majorities, and they also can emanate from preparaton, thus be difficult to show its ultraviolet absorption ability fully, thus cause the stability of kojic acid to reduce.

In order to overcome above-mentioned defective, can suitably adopt some solubilizers, still, use the oiliness solubilizer can bring following problem in a large number: a kind of sensation beastly to be arranged when putting on preparation on the skin as the adhesion sense.

In addition, the external preparation that contains kojic acid for formation is from suppressing the angle of complexion changed, non-ionic surface active agent is a kind of suitable surfactant, and after using said preparation, a kind of pleasant sensation is arranged and harmless to skin, but, non-ionic surface active agent compare with ionic surfactant its emulsifying capacity a little less than, emulsifying capacity can reduce in the presence of high polar component, perhaps be subjected to the influence of pH value, thereby, usually pH value being transferred to 4～5 contain in the kojic acid preparation, the mixing of high polarity UV absorbent can be caused along with the time changes emulsion stability and reduces.

Thereby, the purpose of this invention is to provide a kind of epidermis preparation, this preparation has overcome traditional above-mentioned defective that the kojic acid preparation exists that contains, it is the segregation that ultraviolet absorber can not appear in said preparation, strengthened the stability that changes kojic acid complexion changed and decomposition in time, strengthened the persistency of the usefulness of this composition, said preparation is to make by adding a kind of material that is selected from hydrocarbon, lipid and sclerosis or unhardened fat and oil at least.

Other purpose of the present invention, feature and advantage will fully show by following detailed description to the preferred embodiment for the present invention.

Kojic acid of the present invention (5-hydroxyl-2-methylol-r-pyrrone) is first kind of composition, it can be the pure products of 5-hydroxyl-2-methylol-r-pyrrone, comprise kojic acid and make main composition, again by cultivating the fermentation liquid that the known antibacterial kind that can produce kojic acid obtains, the concentrated solution of fermentation liquid, by fermentation liquid is the product that extracts kojic acid and the extract crystallization is obtained, or the like.

Kojic acid derivative can use separately, perhaps two or more are used in combination, kojic acid derivative is disclosed in for example following document: Japanese unexamined patent publication number S60-10005, H1-45472 and H3-74229, the fat product of kojic acid and its derivant discloses, for example in the Yi Xia document: Japanese unexamined patent publication number S58-22151 and S58-22152, in the above-mentioned fat product, sugar by chain be incorporated into kojic acid 2-position-CH ₂On the OH group.

Kojic acid and/or the incorporation of its derivant in preparation are preferred 0.1～5% (wt) of 0.001～10% (wt), in external preparation total amount.

Being used for the present invention is not particularly limited as the UV absorbent of second kind of composition.Preferred examples comprises: benzophenone derivative is as oxybenzene ketone (cxybenzone), oxybenzene ketosulfonic acid, hydroxyl methoxy benzophenone sodium sulfonate and dihydroxy dimethoxy benzophenone; Salicyclic acid derivatives is as salicylic acid ethylene glycol fat, salicylic acid list  ester and phenyl salicytate; The urocanic acid ethyl ester of urocanic acid; Cinnamic acid derivative as: to methoxyl group carnic acid 2-hexyl ethyl ester and octyl methoxycinnamate; The para-amino benzoic acid derivant is as: para-amino benzoic acid glyceride with to dimethylamino benzoic acid 2-Octyl Nitrite; Dibenzoylmethane derivative as: the 4-tert-butyl group-4 '-methoxy dibenzoyl methane; Benzotriazole derivatives is as 2-(2-hydroxy-5-methyl phenyl) benzotriazole.These chemical compounds can use separately or two or more are used in combination.In addition, other animal or plant extract with ultraviolet absorption ability also can be used alone or in combination aptly.

The consumption of these UV absorbent depends on its kind, but in general, its consumption is preferred 0.1～5% (wt) of 0.001～10% (wt), in external preparation total amount.

The hydrocarbon that is adopted among the present invention is as the third composition, they can be alkane and alkene, as alpha-olefin low polymers, liquid isoparaffin, general Lay bass (plastibase, the NipponSquib product), polyisobutylene and polybutene, the preferred use comprises 10 or more a plurality of carbon atom and low polar those materials.

Phospholipid most preferably in the lipid, the example comprises: phosphoglyceride, as phospholipid acyl chlorides, phosphatidylinositols, PHOSPHATIDYL ETHANOLAMINE, Phosphatidylserine, they extract from natural product and obtain, as egg yolk, Semen sojae atricolor and corn, sphingomyelins; As: sphingomyelins and ceramide ethylphosphonic acid (ceramide ciliatin); Synthetic phospholipid such as glycosyl sphingolipid (sphingoglycolipid), distearyl acyl group phosphatidyl chlorine and two palmityl phosphoryl chloride phosphorus oxychlorides etc.

Complete hardened castor oil that sclerosis or non-sclerosis preferred embodiment fatty and oil can be the degree of polymerization about 40～100 such as polyoxyethylene hardened castor oil, three isostearic acid polyoxyethylene hardened castor oils, the isostearic acid polyoxyethylene hardened castor oil, lauric acid polyoxyethylene hardened castor oil, polyoxyethylene castor oil and polyoxyethylene sorbitol Cera Flava.They can be used singly or in combination.

The consumption of the third composition depends on its kind, but in general, its consumption is preferred 0.1～10% (wt) of 0.001～20% (wt), in the preparation total amount.

Can above-mentioned three kinds of compositions be made external preparation by known method.The segregation of UV absorbent can not appear in this kind preparation, thereby said preparation is a kind of stable emulsification preparation, it changed and to demonstrate good stable along with the time, and wherein kojic acid shows the stability that changes complexion changed and decomposition in time and strengthened, and shows lasting usefulness.

Need not polylogia, dosage form of the present invention is not limited to Emulsion such as O/W Emulsion and W/O Emulsion, the transparent type preparation that can also form for the suitable selection component of a kind of warp, in addition, the present invention also can be suitable for for a kind of basic fundamental with prepare multiple emulsion preparation such as W/O/W or O/W/O Emulsion or little glue again and assist preparation.

Epidermis of the present invention is not specially limited its occupation mode with preparation, it can use with known drug, accurate medicine and the occupation mode that changes into product, as paste, plaster, unguentum, cream, ointment, aerosol, Emulsion, lotion, essence (essence), skin lotion, gellant, powder, foundation cream (foundation), sunscreen (suncare), bath salt (bathsalts) etc.

In formulation preparation process of the present invention, various known effective ingredient commonly used also optionally add, but require its amount can not damage purpose of the present invention, the example of these known effective ingredient comprises: capillary vasodilator, as: carpronium chlorine, cepharanthine, vitamin E, tocopheryl nicotinate fat, nicotinic acid, nicotinamide, nicotinic acid benzene methyl, ginger tincture and capsicum tincture (ginqer tincture, chilitincture); Coolant such as Camphora, menthol and Oleum menthae; Antimicrobial as: hinokitiol, oxidation benzalkonium and+-carbon enoic acid; Antiinflammatory such as adrenocortical hormone, aminocaproic acid, lysozyme chloride, Radix Glycyrrhizae, allantoin; The white Tender agent of skin (fairness inparting agents) is as ascorbic acid and arbutin; Various animals and plants extracts, as: intacellin, liver extract, lithospermam root extract, lactic acid bacteria culture solution extract.

Except known effective ingredient, various additives all can use, as wetting agent, antiseptic, antioxidant, chelating agen, PH regulator, spice, coloring agent, and the substrate composition is as fat and oily, as long as its adding can not damage said medicine of the present invention, the application mode of accurate medicine and cosmetics.

By following example and prescription the present invention is made a more detailed description, they are not limitations of the present invention.

Embodiment 1

The preparation stability test

Experimental technique:

According to the various cream of formulation shown in the table 1 (PH about 4.5), they are placed 4 ounces wax bottle, placed 2 months and used simultaneously ultraviolet radiation down at 50 ℃, after 2 months, measure its aberration (Δ E) (the 2-1001DP type color difference meter that uses Nihon Denshoku Rogyo to make), simultaneously its cosmetic variation is observed (segregation of UV absorbent and the stability of Emulsion) and assessed its effect.

Experiment effect:

As shown in table 1, the segregation of UV absorbent does not appear in preparation of the present invention, has shown splendid emulsion stability simultaneously.The complexion changed of the kojic acid that is comprised in the preparation does not observe, and application is felt good.

Table 1-1

The component title	Embodiment
									1	2	3	4	5	6	7	8
	1. 6. 7. Emulsifier EL-60 8. polyoxyethylene sorbitol beeswaxs of isostearic acid polyoxyethylene fixed oil (60E.O.) of plastic substrate 2. soybean lecithins 3. phosphatid ylcholine 4. sphingomyelins, 5. polyoxyethylene fixed oils (40E. O.)	5.00 - - - - - - -	5.00 2.00 - - - - - -	2.00 - 5.00 - - - - -	- - - 0.50 - - - -	- - 0.50 - 1.50 - - -	- - - - - 0.50 - -	- 2.00 - - - - 1.50 -									- - - - - - - 3.00
9. kojic acid									1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00
	10.Oxybenzon the 11.4-tert-butyl group-4 '-methoxyl group-dibenzoyl methane 12. p-aminobenzoic acid glyceride 13. glycol salicylates 14. octyl methoxycinnamates	1.50 - - - -	- 1.00 - - -	0.80 0.50 - - -	- - 0.20 - -	- - - 1.00 -	- - - - 0.50	- 0.20 0.10 - -									- - 1.50 - 0.10
15. beeswax 16. vaseline 17. jojoba oils, 18. natural VEs, 19. polyoxyethylene cetyl ether (25E. O.)									4.50 2.80 7.00 0.04 1.50	4.50 2.80 7.00 0.04 1.50	4.50 2.80 7.00 0.04 1.50	4.50 2.80 7.00 0.04 1.50	4.50 2.80 7.00 0.04 1.50	4.50 2.80 7.00 0.04 1.50	4.50 2.80 7.00 0.04 1.50	4.50 2.80 7.00 0.04 1.50

20. polyoxyethylene stearyl acyl group ether (20E.O.) 21. carboxy vinyl polymer 22.dl-pyrrolidone sodium carboxylates 23. disodium ethylene diamine tetraacetates 24. citric acids 25. natrium citricums 26. pure water			0.70 0.08 6.00 0.02 *1 *1 *2	0.70 0.08 6.00 0.02 *1 *1 *2	0.70 0.08 6.00 0.02 *1 *1 *2	0.70 0.08 6.00 0.02 *1 *1 *2	0.70 0.08 6.00 0.02 *1 *1 *2	0.70 0.08 6.00 0.02 *1 *1 *2	0.70 0.08 6.00 0.02 *1 *1 *2	0.70 0.08 6.00 0.02 *1 *1 *2
											Test result	Performance	*3	Do not have	Do not have	Do not have	Do not have	Do not have	Do not have	Do not have	Do not have
*4	⊙	⊙	⊙	⊙	⊙	⊙	⊙	⊙
									(Δ E) aberration				3.2	3.1	3.0	2.3	3.0	2.9	2.5	2.3
Use feeling evaluation (* 5)	*6	⊙	⊙	⊙	⊙	⊙	⊙	⊙				⊙
									*7	⊙			⊙	⊙	⊙	⊙	⊙	⊙	⊙
	*8	⊙	⊙	⊙	⊙	⊙	⊙	⊙				⊙

* 1: micro-* 2: be enough to make total amount to reach the amount * 3 of 100% (weight): separate UV absorbent * 4: emulsion state (separation)

⊙: good; △: part is separated; *: separate * 5: evaluation criterion:

⊙: good; Zero: almost no problem; △: slight problem is arranged;

*: bad * 6: harsh feeling * 7: adhesion sense * 8: skin is comfortable

Table 1-2

The component title	The comparative example
										1	2	3	4	5	6	7	8	9
	1. 6. 7. Emulsifier EL-60 8. polyoxyethylene sorbitol beeswaxs of isostearic acid polyoxyethylene hardened castor oil (60E.O.) of plastic substrate 2. soybean lecithin 3. phosphatid ylcholines, 4. sphingomyelins, 5. polyoxyethylene hardened castor oils (40E. O.)	- - - - - - - -	- - - - - - - -	- - - - - - - -	- - - - - - - -	- - - - - - - -	- - - - - - - -	- - - - - - - -	- - - - - - - -										- - - - - - - -
9. kojic acid										1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00
	10.Oxybenzon the 11.4-tert-butyl group-4 '-methoxyl group-dibenzoyl methane 12. p-aminobenzoic acid glyceride 13. glycol salicylates 14. octyl methoxycinnamates	- - - -	1.50 - - - -	- 1.00 - - -	0.80 0.50 - -	- - 0.20 - -	- - - 1.00 -	- - - - 0.50	- 0.20 0.10 - -										- - 1.50 - 0.10
15. beeswax 16. vaseline 17. jojoba oils, 18. natural VEs, 19. polyoxyethylene cetyl ether (25E. O.)										4.50 2.80 7.00 0.04 1.50	4.50 2.80 7.00 0.04 1.50	4.50 2.80 7.00 0.04 1.50	4.50 2.80 7.00 0.04 1.50	4.50 2.80 7.00 0.04 1.50	4.50 2.80 7.00 0.04 1.50	4.50 2.80 7.00 0.04 1.50	4.50 2.80 7.00 0.04 1.50	4.5 2.8 7.00 0.04 1.50

20. polyoxyethylene stearyl acyl group ether (20E.O.) 21. carboxy vinyl polymer 22.dl-pyrrolidone sodium carboxylates 23. disodium ethylene diamine tetraacetates 24. citric acids 25. natrium citricums 26. pure water			0.70 0.08 6.00 0.02 *1 *1 *2	0.70 0.08 6.00 0.02 *1 *1 *2	0.70 0.08 6.00 0.02 *1 *1 *2	0.70 0.08 6.00 0.02 *1 *1 *2	0.70 0.08 6.00 0.02 *1 *1 *2	0.70 0.08 6.00 0.02 *1 *1 *2	0.70 0.08 6.00 0.02 *1 *1 *2	0.70 0.08 6.00 0.02 *1 *1 *2	0.70 0.80 6.00 0.02 *1 *1 *2
												Test result	Performance	*3	-	Do not have	Have	Have	Have	Have	Have	Have	Have
*4	△	×	×	×	×	×	×	×	×
										(Δ E) aberration				9.1	8.5	7.7	7.9	10.3	7.2	8.6	8.1	6.5
Use feeling evaluation (* 5)	*6	○	○	○	×	×	×	×	×				×
										*7	△			×	×	△	△	△	△	×	×
	*8	△	△	×	△	×	△	×	×				△

* 1: micro-* 2: be enough to make total amount to reach the amount * 3 of 100% (weight): separate UV absorbent * 4: emulsion state (separating)

⊙: good; △: part is separated; *: separate * 5: evaluation criterion:

⊙: good; Zero: almost no problem; △: slight problem is arranged;

*: bad * 6: harsh feeling * 7: adhesion sense * 8: the comfortable embodiment 2 of skin

Pigmentation by the photoinduced Cavia porcellus of UV is suppressed effect, measure the effect that suppresses pigmentation with the yellowish-brown Cavia porcellus.

Table 2 has been listed this result of experiment,

From the result of table 2 as can be seen, preparation of the present invention has showed fabulous and persistent pigmentation inhibitory action.

Experimental technique:

Cut yellow guinea pig back hair and make its skin of back exposed, shave clean exposed skin of back place with electric shaver.The back of shaving with one have four square holes (2.0 * 2.0cm) aluminium foil covers, and per three days once, (the 3SE lamp is arranged with UV-B totally four times; 140mj/cm ²) shone every day 90 seconds, from ten days (every day three times) of Continuous irradiation, the test position that will the experiment 1 every kind of preparation that obtains is used to shine.At the 10th day and the 20th day that begins to shine UV light, pigmentation is marked.

The blackening degree of test skin is marked with bore hole according to following standard.

Standards of grading:

3: do not observe pigmentation

2: observe slight pigmentation

1: observe the moderate pigmentation

0: observed pigmentation degree is identical with contrast position (not treatment).

-1: it is stronger that observed pigmentation degree contrasts position (not treatment).

Table 2-1 experimental result

The component title	Embodiment
									1	2	3	4	5	6	7	8
	1. 6. 7. Emulsifier EL-60 8. polyoxyethylene sorbitol beeswaxs of isostearic acid polyoxyethylene fixed oil (60E.O.) of plastic substrate 2. soybean lecithins 3. phosphatid ylcholine 4. sphingomyelins, 5. polyoxyethylene fixed oils (40E. O.)	5.00 - - - - - - -	5.00 2.00 - - - - - -	2.00 - 5.00 - - - - -	- - - 0.50 - - - -	- - 0.50 - 1.50 - - -	- - - - - 0.50 - -	- 2.00 - - - - 1.50 -									- - - - - - - 3.00
9. kojic acid									1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00
	10.Oxybenzon the 11.4-tert-butyl group-4 '-methoxyl group-dibenzoyl methane 12. p-aminobenzoic acid glyceride 13. glycol salicylates 14. octyl methoxycinnamates	1.50 - - - -	- 1.00 - - -	0.80 0.50 - - -	- - 0.20 - -	- - - 1.00 -	- - - - 0.50	- 0.20 0.10 - -									- - 1.50 - 0.10
15. beeswax 16. vaseline 17. jojoba oils, 18. natural VEs, 19. polyoxyethylene cetyl ether (25E. O.)									4.50 2.80 7.00 0.04 1.50	4.50 2.80 7.00 0.04 1.50	4.50 2.80 7.00 0.04 1.50	4.50 2.80 7.00 0.04 1.50	4.50 2.80 7.00 0.04 1.50	4.50 2.80 7.00 0.04 1.50	4.50 2.80 7.00 0.04 1.50	4.50 2.80 7.00 0.04 1.50

20. polyoxyethylene stearyl acyl group acid (20E.O.) 21. carboxy vinyl polymer 22.dl-pyrrolidone sodium carboxylates 23. disodium ethylene diamine tetraacetates 24. citric acids 25. natrium citricums 26. pure water			0.70 0.08 6.00 0.02 *1 *1 *2	0.70 0.08 6.00 0.02 *1 *1 *2	0.70 0.08 6.00 0.02 *1 *1 *2	0.70 0.08 6.00 0.02 *1 *1 *2	0.70 0.08 6.00 0.02 *1 *1 *2	0.70 0.08 6.00 0.02 *1 *1 *2	0.70 0.08 6.00 0.02 *1 *1 *2	0.70 0.08 6.00 0.02 *1 *1 *2
											The effect scoring	The chromogenesis degree	The 10th day	0	0	0	0	0	0	0	0
The 20th day	3	3	3	3	3	3	3	3

* 1: micro-* 2: be enough to make total amount to reach the amount of 100% (weight)

Table 2-2 experimental result

The component title	The comparative example
										1	2	3	4	5	6	7	8	9
	1. 6. 7. Emulsifier EL-60 8. polyoxyethylene sorbitol beeswaxs of isostearic acid polyoxyethylene hardened castor oil (60E.O.) of plastic substrate 2. soybean lecithin 3. phosphatid ylcholines, 4. sphingomyelins, 5. polyoxyethylene hardened castor oils (40E. O.)	- - - - - - - -	- - - - - - - -	- - - - - - - -	- - - - - - - -	- - - - - - - -	- - - - - - - -	- - - - - - - -	- - - - - - - -										- - - - - - - -
9. kojic acid										1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00	1.00
	10.Oxybenzon the 11.4-tert-butyl group-4 '-methoxyl group-dibenzoyl methane 12. p-aminobenzoic acid glyceride 13. glycol salicylates 14. octyl methoxycinnamates	- - - -	1.50 - - - -	- 1.00 - - -	0.80 0.50 - -	- - 0.20 - -	- - - 1.00 -	- - - - 0.50	- 0.20 0.10 - -										- - 1.50 - 0.10
15. Cera Flava 16. vaseline 17. simmondsia oils 18. natural Vitamin E										4.50 2.80 7.00 0.04	4.50 2.80 7.00 0.04	4.50 2.80 7.00 0.04	4.50 2.80 7.00 0.04	4.50 2.80 7.00 0.04	4.50 2.80 7.00 0.04	4.50 2.80 7.00 0.04	4.50 2.80 7.00 0.04	4.50 2.80 7.00 0.04

19. polyoxyethylene cetyl ether (25E.O.) 20. polyoxyethylene stearyl acyl group ethers (20E.O.) 21. carboxy vinyl polymer 22.dl-pyrrolidone sodium carboxylates 23. disodium ethylene diamine tetraacetates 24. citric acids 25. natrium citricums 26. pure water			1.50 0.70 0.08 6.00 0.02 *1 *1 *2	1.50 0.70 0.08 6.00 0.02 *1 *1 *2	1.50 0.70 0.08 6.00 0.02 *1 *1 *2	1.50 0.70 0.08 6.00 0.02 *1 *1 *2	1.50 0.70 0.08 6.00 0.02 *1 *1 *2	1.50 0.70 0.08 6.00 0.02 *1 *1 *2	1.50 0.70 0.08 6.00 0.02 *1 *1 *2	1.50 0.70 0.08 6.00 0.02 *1 *1 *2	1.50 0.70 0.08 6.00 0.02 *1 *1 *2
												The effect scoring	The chromogenesis degree	The 10th day	0	0	0	0	0	0	0	0	0
The 20th day	1	1	1	1	1	1	1	1	1

* 1: micro-* 2: be enough to make total amount to reach the amount of 100% (weight)

Represented preparation embodiment of the present invention below.

Preparation embodiment 1[cream (1)]

(weight %) 1, kojic acid 1.002, phenolsulfonic acid (Oxybnzenesulfonicacid) 0.503, phosphatidylcholine 2.004, polyoxyethylene hardened castor oil (40E, O) 3.005, polyoxyethylene cetyl ether (25E, O) 5.006, stearic acid 5.007, American Avocado Tree oil 1.008, almond oil 10.009, dl-pyrrolidone sodium carboxylate solution 5.0010, p-Hydroxybenzoate 0.2011, disodiumedetate 0.0112, purified water adds to 100.00

Preparation embodiment 2[cream (2)]

(weight %) 1, kojic acid 5.002, the 4-tert-butyl group-4 '-methoxyl group-dibenzoyl methane 0.503, PHOSPHATIDYL ETHANOLAMINE 1.004, polyoxyethylene castor oil 0.205, plastic substrate 3.006, polyoxyethylene hydration lanoline 3.007, simmondsia oil 7.008, decyl ring penta siloxanes 3.009, octyl group ring fourth siloxanes 3.0010, dimethyl polysiloxane 5.0011, natural Vitamin E 0.0412,1% sodium hyaluronate solution 2.0013, carrageenin 1.0014, disodiumedetate 0.0115, purified water adds to 100.00

Preparation embodiment 3[Emulsion (1)]

(weight %) 1, kojic acid 4.002,2-ethyl diethyldithiocarbamate-p-methoxycinnamic acid ester 2.003, squalane 4.004, ceramide 2.005, polyoxyethylene cetyl ether (25E, O) 0.056, polyoxyl 10 oleyl ether 1.007, stearic acid 0.058, Adeps Bovis seu Bubali resin 0.059, American Avocado Tree oil 4.0010, p-Hydroxybenzoate 0.2011 Quince smoke tree seed extract 5.0012, xanthan gum 0.1413, disodiumedetate 0.0114, purified water adds to 100.00

Preparation embodiment 4[Emulsion (2)]

(weight %) 1, kojic acid 0.052, glycol salicylate 0.103, octyl methoxycinnamate 2.004, polyoxyethylene sorbitol Cera Flava 0.505, light liquid paraffin 4.006, the sour single ethanol amide 2.007 of cupu oil fat, stearic acid 0.508, myristic acid 0.509, American Avocado Tree oil 4.0010, natural level is given birth to plain E 0.0411, p-Hydroxybenzoate 0.2012, hyaluronate sodium 5.0013, xanthan gum 0.1414, disodiumedetate 0.0115, purified water adds to 100.00

Preparation embodiment 5[lotion]

(weight %) 1, kojic acid heteroside 7.002, uncle 4-Ding-4 '-methoxyl group-dibenzoyl methane 2.003,2-ethylhexyl-p-methoxycinnamic acid ester 0.054, lauric acid polyoxyethylene hardened castor oil (100E, O) 3.005, polyoxyethylene cetyl ether (60E, O) 5.006, Radix Ginseng extract 2.007, Japan chirate extract 0.508, p-Hydroxybenzoate 0.109, ascorbic acid 0.1010, sodium citrate 0.3011,5% elastin laminin hydrolyzed solution 4.0012, disodiumedetate 0.0113, purified water adds to 100.00

Preparation embodiment 6[cream skin lotion]

(weight %) 1, kojic acid ethyl ester 2.002, the 4-tert-butyl group-4 '-methoxyl group-dibenzoyl methane 0.503, three isostearic acid polyoxyethylene hardened castor oil (100E, O) 2.004, phosphatidylinositols 5.005, Stearic acid diethanolamine salt 5.006, stearic acid 5.007, myristic acid 0.508, cupu oil 15.009, natural Vitamin E 0.0410, p-Hydroxybenzoate 0.2011, dl-pyrrolidone sodium carboxylate solution 5.0012, disodiumedetate 0.0113, purified water adds to 100.00

Preparation embodiment 7 [ointment]

(weight %) 1; kojic acid 1.002; phenolsulfonic acid 0.103; phenyl salicytate 0.404; hydroxyl methoxybenzene and benzoyl sodium sulfonate 1.00 (Sodium hydroxymethoxy benzophenonesulfonate) 5; plastic substrate 2.006; cocoa grease fat acid single ethanol amide 5.007; vaseline 10.008; stearic acid 5.009; oleic acid 1.0010; olive oil 10.0011; p-Hydroxybenzoate 0.2012; carrageenin 5.0013; disodiumedetate 0.0114; purified water adds to 100.00

Preparation embodiment 8[paste]

(weight %) 1, kojic acid fructoside 0.502, p-aminophenyl first glyceride 4.003, iso stearate polyoxyethylene hardened castor oil 1.004, hard ester acid diglycollic amide 3.005, polyacrylic acid 27.006, Radix Glycyrrhizae extract (ethanol extraction) 0.107, Radix Scutellariae root extract (water extract) 0.058, disodiumedetate 0.059, sodium polyacrylate 7.0010, aluminum chloride 0.3011, concentrated glycerin 20.0012, titanium oxide 4.0013, purified water adds to 100.00

Preparation embodiment 9[essence]

(weight %) 1, kojic acid 1.002, urocanic acid 0.053,2-ethylhexyl-p-methoxycinnamic acid ester 1.004, liquid isoparaffin 0.055, dipalmitoyl phosphatidyl choline 1.506, the sour single ethanol amide 2.007 of cupu oil fat, stearic acid 0.508, linolenic acid 0.509, American Avocado Tree oil 2.0010, Oleum Testudinis 3.0011, natural Vitamin E 0.0412, p-Hydroxybenzoate 0.2013,1% carboxy vinyl polymer aqueous solution 5.0014, xanthan gum 0.1415, disodiumedetate 0.0116, purified water adds to 100.00

Confirmed that above-mentioned preparation embodiment 1-9 provides the preparation with same satisfactory effect (as shown in table 1 and 2).

Under the prerequisite that does not deviate from the present invention's spirit and basic feature, the present invention can other particular form realize.Therefore concrete scheme of the present invention all is considered to be illustrative rather than definitive thereof scope of the present invention in every respect, description by additional claim rather than front indicates, and comprising the whole variations that in suitable method of claim and scope, take place.

Claims (1)

1. epidermis preparation, be that the UV absorbent of adding 0.1～5 weight % in the external preparation of the kojic acid that contains 0.1～5 weight % and/or its more than one derivants and non-ionic surface active agent forms, it is characterized in that, when cooperating UV absorbent therein, that adds 0.1～10 weight % is selected from least a of hydrocarbon, fat and sclerosis or non-hardened fat

Described hydrocarbon is selected from liquid paraffinic hydrocarbon and the general dish bass with 10 above carbon atoms;

Described fat is the phospholipid that is selected from phosphatidylcholine, soybean phospholipid, two palmityl phosphatidylcholines, ceramide, phosphatidylinositols, PHOSPHATIDYL ETHANOLAMINE, sphingomyelins;

Described sclerosis or non-hardened fat are selected from polyoxyethylene hardened castor oil, isostearic acid polyoxyethylene hardened castor oil, lauric acid polyoxyethylene hardened castor oil, the polyoxyethylene sorbitol Cera Flava of the degree of polymerization 40～100.