CN109011221A - A kind of the neutron capture therapy system and its operating method of dosage guidance - Google Patents

Abstract

The invention belongs to the technical field of radiotherapy, and discloses a dose-guided boron neutron capture therapy system, comprising: a low-energy linear accelerator system for providing stable proton beams; a neutron irradiation system for providing therapeutic neutron beams The patient is irradiated to the target area for irradiation, including the neutron beam irradiation port; the treatment assistance system is used for patient positioning and formulating, verifying and executing the treatment plan; the dose guidance system is used for monitoring and adjusting the treatment plan. The treatment system realizes real-time monitoring of the patient's irradiation target area during BNCT treatment, obtains the three-dimensional boron-10 concentration distribution of the patient's irradiation target area, and adjusts the treatment plan according to the patient's three-dimensional boron-10 concentration distribution , to achieve the precise irradiation execution of the treatment plan, so as to avoid as much as possible the problems of decreased tumor control rate due to insufficient irradiation target dose in BNCT treatment or increased incidence of complications due to excessive normal tissue dose.

Description

A dose-guided neutron capture therapy system and method of operation thereof

technical field

The invention belongs to the technical field of radiotherapy, and in particular relates to a dose-guided neutron capture therapy system and an operating method thereof.

Background technique

Boron Neutron Capture Therapy (BNCT) is a bio-targeted binary radiotherapy mode with "drug-machine combination" and better safety. It has the advantages of radiotherapy, chemotherapy, heavy ion therapy and other means in principle Advantages, the most hopeful realization of human good wishes to cure tumors. BNCT treatment first injects non-toxic boron-doped drugs with pro-tumor tissue into human blood, and after the boron (boron-10) drugs are enriched in tumor tissues, epithermal neutrons are used to irradiate the tumor in multiple directions conformally. When the protons meet the boron-10 nuclides in cancer cells and undergo a nuclear reaction, the released alpha particles and lithium-7 particles have strong lethality to cells, and the killing effect is higher than that of existing X-rays, gamma-ray radiotherapy and protons. For radiotherapy, the side effects of BNCT are relatively small, and with the further improvement of the pro-tumor effect of boron-doped drugs, the damage of BNCT to normal tissues will be further reduced. BNCT has a wide range of tumor indications, and can treat diffuse malignant tumors that cannot be treated by protons and heavy ions or tumors that recur after treatment, such as in glioblastoma multiforme (malignant brain cancer), recurrent head and neck cancer, etc. Carcinoma, malignant melanin skin cancer, liver metastases, etc., the treatment effect is significantly better than the existing treatment technology.

During BNCT treatment, the dose received by patients directly determines the tumor control rate and complication rate of BNCT treatment, which in turn affects the quality of life of patients after treatment. Therefore, accurate tumor positioning, precise treatment plan, and precise irradiation execution are the three key links of BNCT precision treatment, but the "precise irradiation execution" still faces many difficulties. The dose generated by BNCT treatment is derived from the nuclear reaction between thermal neutrons and boron-10, and boron-10 will change in time-space distribution with the metabolism of boron-doped drugs in the patient's body. This spatio-temporal variation in the metabolism of boron-doped drugs is apparently random, resulting in deviations between the doses patients receive and the doses specified in the treatment plan. Large deviations may result in decreased tumor control rates or increased complication rates in BNCT therapy.

In the current BNCT clinical treatment process, the boron concentration changes with time using the following approximate processing method: during the infusion of boron-doped drugs before irradiation, the blood samples of the patient are collected at intervals, and the boron in the blood samples is detected. Combined with the ratio of tumor tissue to blood boron concentration (T/N) determined by ¹⁸ F-BPA-PET nuclear medicine imaging means, the empirical curve of boron-doped drug metabolism over time was revised, and the irradiation time was finally determined. The problem is that the boron concentration of tumor tissue changes over time based on empirical model derivation rather than online real-time measurement results, and the influence of the uneven spatial distribution of boron concentration is not considered, resulting in large uncertainty in the actual dose received by patients sex.

Based on the above situation, it is necessary for us to design a neutron capture therapy system that can solve the above problems.

Contents of the invention

The purpose of the present invention is to propose a dose-guided neutron capture therapy system, based on the prompt gamma photons released by the reaction of thermal neutrons and boron-10 in the BNCT treatment process, the target is irradiated to the irradiated object through the detector array Three-dimensional measurement is carried out in the area, the emitted gamma photons are detected and reflected by calculation as the real-time boron-10 concentration distribution and the received three-dimensional dose distribution of the target area irradiated by the irradiated object, and the parameters of the treatment plan are adjusted accordingly, thus greatly Improve the precision level of the BNCT treatment process.

To achieve this purpose, the first aspect of the present invention proposes a dose-guided boron neutron capture therapy system, including:

A low-energy linear accelerator system for providing a stable proton beam;

The neutron irradiation system, including a neutron beam irradiation port, is used to provide a therapeutic neutron beam to irradiate the target area of the irradiated object, and is connected to the low-energy linear accelerator system;

Treatment assistance system, used for tumor localization, formulation of treatment plan, verification and execution of treatment plan during neutron capture tumor treatment;

The dose guidance system is used for real-time dose monitoring and real-time treatment plan adjustment during neutron capture tumor treatment, and is respectively connected with the neutron irradiation system and the treatment assistance system.

It should be noted that the subject to be irradiated in the present invention mainly refers to patients suffering from tumors receiving neutron beam irradiation treatment, referred to as patients.

Further, the treatment assistance system includes a treatment planning system, a control system, a positioning and positioning system, a control module, a preparation room, an isolation and shielding room, and an irradiation room, and the isolation and shielding room is set between the irradiation room and the irradiation room. Between, the neutron beam irradiation port of the neutron irradiation system is set in the irradiation chamber.

Further, the treatment planning system includes a plan formulation module and a plan verification module. The plan making module can generate a treatment plan, and the plan verification module can verify the treatment plan. After the verification of the treatment plan is completed, the treatment can be carried out according to the treatment plan.

Further, the treatment planning system also includes a treatment and curative effect evaluation module to evaluate the treatment process and curative effect.

Further, the positioning and positioning system includes a simulated irradiation port, a treatment bed, guide rails, an automatic alignment device, and a setup verification device. The guide rails are laid in the preparation room and extend to the irradiation room. Moving back and forth between the preparation room and the irradiation room along the guide rail. The automatic alignment device can quickly lock the treatment couch and determine the position of the treatment couch; the setup verification system is used for quickly positioning the object to be irradiated and confirming the position to the irradiation position. Further, the dose guidance system includes a dose monitoring system, a boron drug infusion system, and a treatment plan adjustment system, and the dose monitoring system and the boron drug infusion system are respectively connected to the treatment plan adjustment system by electrical signals, so The treatment plan adjustment system performs data collection and action control on the dose monitoring system and the boron drug infusion system.

Further, the dose guidance system includes a dose monitoring system, a boron drug infusion system, and a treatment plan adjustment system. The dose monitoring system and the boron drug infusion system are respectively connected to the treatment plan adjustment system. The plan adjustment system performs data collection and action control on the dose monitoring system and the boron drug infusion system respectively.

Further, the dose monitoring system includes a radiation detection part and a calculation part, the radiation detection part is used to detect the prompt gamma photons emitted by the irradiated object and convert them into energy spectrum data, and the calculation part is used to convert the The energy spectrum data detected by the radiation detection department is calculated and analyzed as the boron-10 concentration distribution.

Further, the radiation detection part includes a collimator, a detection body, and a shielding body, and the collimation body and the detection body are arranged inside the shielding body. The collimator is used to collimate the rays emitted by the measured object, and the detection body is used to convert the collimated optical signal into electrical signal and energy spectrum data. Further, the collimating holes on the collimating body are uniformly arranged in a two-dimensional array. Further, the collimator is a grid collimator made of tungsten plate or lead plate.

Further, the detection body is composed of a plurality of detection units, each detection unit is arranged in a matrix, and the detection units are in one-to-one correspondence with the collimation holes.

Further, each detection unit includes a detection crystal module, a signal collection and amplification module, and a signal processing module, and the detection crystal module, the signal collection and amplification module, and the signal processing module are connected in sequence. The detection crystal module is used to detect the collimated optical signal, the signal collection and amplification module amplifies the signal detected by the detection crystal module, and the signal processing module digitally converts the amplified signal to generate and Multi-channel energy spectrum data corresponding to the energy of incident gamma rays.

Further, the radiation detection parts are in pairs and arranged symmetrically around the object to be irradiated. By symmetrically arranging the radiation detection part and combining the anticoincidence circuit, the energy of 511keV and the opposite direction of the gamma photon released by the annihilation reaction of the positron-electron pair can be efficiently screened to eliminate the noise gamma photon.

Further, the radiation detection part can rotate around the object to be irradiated. Specifically, its spatial position can be adjusted by translation or rotation according to detection requirements, and the distance between the paired radiation detection parts can be adjusted according to detection requirements.

Further, the calculation section of the dose monitoring system analyzes and calculates the multi-channel energy spectrum data detected by the radiation detection section, obtains the boron-10 capture reaction rate distribution and the boron dose rate distribution of the irradiation target area, and further calculates Obtain the current boron-10 concentration distribution, that is, obtain the real-time three-dimensional distribution of boron-10 concentration in the irradiation target area.

Further, the boron drug infusion system is used to further infuse boron-doped drugs to patients during BNCT treatment, including an infusion line, an infusion pump, and a boron drug storage container.

Further, the infusion pump and the boron drug storage container are arranged outside the irradiation room to avoid being irradiated by the radiation of the irradiation room, and the infusion pipeline can introduce the boron-doped drug into the irradiation room to infuse the patient with boron-doped drug .

Further, the treatment plan adjustment system includes a calculation module and an operation module, the calculation module is used to process the information collected from the radiotherapy planning system, the dose monitoring system and the boron drug infusion system, and calculate the irradiation time adjustment range and supplementary infusion The boron dose generates a treatment plan adjustment scheme, and the operation module is used to display the treatment plan adjustment scheme and operate the treatment plan adjustment scheme.

Further, the treatment assistance system includes a treatment planning system, a control system, a positioning system, a preparation room, an isolation shielding room and an irradiation room, and the isolation shielding room is set between the irradiation room and the preparation room, The neutron beam irradiation port of the neutron irradiation system is arranged in the irradiation chamber.

Further, the positioning and positioning system includes a simulated irradiation port, a treatment bed, guide rails, an automatic alignment device, and a setup verification device. The guide rails are laid in the preparation room and extend to the irradiation room. Moving back and forth between the preparation room and the irradiation room along the guide rail.

The second aspect of the present invention proposes a method for operating a dose-guided boron neutron capture therapy system, comprising the following steps:

A. Proton beams are provided by the low-energy linear accelerator system 100;

B. Convert proton beams into neutron beams through a neutron beam system;

C. Provide a treatment plan and complete positioning through the treatment assistance system 300;

D. According to the treatment plan, use the neutron beam to irradiate the target area of the patient;

E. Formulate a treatment adjustment plan through the dose guidance system 400;

F. Compare the treatment plan adjustment plan with the treatment plan, and judge whether it is within the acceptable error range. If not, adjust the treatment plan according to the treatment plan adjustment plan and then perform step D. If yes, perform the next step;

G. Compare the actual radiation dose with the treatment plan radiation dose, and judge whether the actual radiation dose reaches the treatment plan radiation dose, if not, proceed to step D, and if so, proceed to the next step;

H. Stop neutron beam irradiation and complete BNCT treatment.

The beneficial effects of the present invention are:

The invention provides a dose-guided boron neutron capture therapy system. On the one hand, it realizes the real-time monitoring of the patient's irradiated target area during the BNCT treatment process, obtains the three-dimensional boron-10 concentration distribution of the patient's irradiated target area, and reduces the The difference in the metabolism of boron-doped drugs in the human body causes uncertainty in the patient's dose. On the other hand, according to the three-dimensional boron-10 concentration distribution of the patient's irradiation target area, the treatment plan is adjusted to achieve precise irradiation execution of the precise radiotherapy plan. In this way, problems such as decreased tumor control rate due to insufficient irradiation target dose in BNCT treatment or increased complication rate due to excessive normal tissue dose can be avoided as much as possible.

Description of drawings

Fig. 1 is a block diagram of the present invention;

Fig. 2 is a structural representation of the present invention;

Fig. 3 is a schematic diagram in the irradiation chamber of the present invention;

Fig. 4 is a schematic flow chart of the operation method of the present invention.

Among them, the low-energy linear accelerator system 100; the neutron irradiation system 200, the neutron beam irradiation port 210; the treatment auxiliary system 300, the preparation room 310, the simulated irradiation port 321, the treatment bed 322, the guide rail 323, the first docking mechanism 3241, the second Docking mechanism 3242 , first optical camera 3251 , second optical camera 3252 , isolation shielding room 330 , irradiation room 340 ; dose guidance system 400 , radiation detection unit 411 .

Detailed ways

In order to have a further understanding and understanding of the structural features of the present invention and the achieved effects, the preferred embodiments and accompanying drawings will be used for a detailed description, as follows:

As shown in Figure 1, a dose-guided boron neutron capture therapy system includes: a low-energy linear accelerator system 100, a neutron irradiation system 200, a treatment assistance system 300 and a dose-guiding system 400, the neutron irradiation system 200 and the low-energy linear accelerator system The accelerator system 100 is connected, and the neutron irradiation system 200, the treatment assistance system 300 and the dose guidance system 400 are electrically connected.

The low-energy linear accelerator system 100 can generate proton beams and accelerate the energy of the proton beams to between 2.5-20 MeV, so as to better provide the neutron irradiation system 200 with stable and satisfactory proton beams.

The neutron irradiation system 200, including the neutron beam irradiation port 210, can convert the proton beam provided by the low-energy linear accelerator system 100 into an initial neutron beam, and shape the energy spectrum of the generated initial neutron beam to obtain an epithermal neutron beam. The neutron beam used for neutron-based treatment, the neutron beam is emitted from the neutron beam irradiation port 210, reaches the patient's irradiation target area, and is irradiated according to the parameters of the treatment plan.

As shown in Figure 2, the treatment assistance system 300 includes a treatment planning system, a control system, a positioning system, a preparation room 310, an isolation and shielding room 330, and an irradiation room 340, and the isolation and shielding room 330 is arranged between the preparation room 310 and the irradiation room 340. Meanwhile, the neutron beam irradiation port 210 of the neutron irradiation system 200 is provided in the irradiation chamber 340 . Specifically, the treatment planning system is set in the preparation room 310, and the positioning and positioning system and the dose guidance system 400 are arranged in the preparation room 310 and the irradiation room 340, so that patients can receive irradiation treatment in the irradiation room 340, while other The medical staff only need to monitor and operate in the preparation room 310 to confirm the safety of the medical staff.

As an improvement of the present invention, the treatment planning system includes a plan formulation module and a plan verification module. The plan formulation module can generate the treatment plan, and the plan verification module can verify the treatment plan.

During BNCT treatment, before using neutron beams for irradiation, it is necessary to inject boron-containing drugs into the patient's body. Boron-containing drugs have pro-tumor properties and will be enriched in the tumor area. Medical imaging to obtain the current distribution characteristics of boron-doped drugs in the patient's body, and establish a boron-doped drug model for dose calculation, based on which the treatment plan is formulated. The input parameters include tumor target parameters, boron-doped drug parameters and neutron beam parameters , tumor target area parameters include tumor location, tumor size, etc., boron-doped drug parameters include boron-10 concentration distribution and its metabolism curve in vivo, neutron beam parameters include irradiation time, irradiation angle, irradiation intensity, etc. It should be noted that the concentration of boron-doped drugs and the concentration of boron-10 in this paper have a one-to-one correspondence, that is, the concentration of boron-doped drugs can be converted to obtain the physical quantity of boron-10 concentration. According to the established model, a treatment plan can be formulated, and the established treatment plan can be verified through the verification module. After the verification is passed, the irradiation treatment can be carried out according to the treatment plan. However, the determination of each parameter in the treatment plan is based on the distribution of boron preparations in the patient's body before irradiation, but boron-10 will change in time-space distribution with the metabolism of boron preparations in the patient's body, that is, the actual radiation required by the patient The parameters and the actual radiation dose will deviate from the treatment plan to a certain extent. Large deviations may result in decreased tumor control rates or increased complication rates in BNCT therapy.

The treatment planning system also includes a treatment and curative effect evaluation system to evaluate the treatment process and curative effect. Evaluation can be to evaluate the treatment parameters during the treatment process and the treatment effect after treatment, so as to evaluate the feasibility of the treatment plan and provide reference for the formulation and verification of the treatment plan in the future.

As an improvement of the present invention, the positioning and positioning system includes a simulated irradiation port 321, a treatment bed 322, a guide rail 323, an automatic alignment device, and a positioning verification device. The guide rail 323 is laid in the preparation room 310 and extends into the irradiation room 340, The treatment bed 322 moves back and forth between the preparation room 310 and the irradiation room 340 along the guide rail 323 . The automatic alignment device can quickly lock the treatment couch 322 and determine the position of the treatment couch 322; the setup verification system is used to quickly set the patient up and confirm that the patient is in the irradiation position. The automatic alignment device is mainly used for determining the position of the treatment couch 322 and fixing the treatment couch 322, and the setup verification system is mainly used for determining the positions of tumors and normal tissues.

Wherein, the treatment couch 322 is arranged at a suitable position of the neutron beam irradiation port 210 so that patients can receive neutron beam irradiation treatment. In this embodiment, the treatment couch 322 is placed in a direction parallel to the direction of the neutron beam streamline.

The automatic alignment device includes a first docking mechanism 3241 installed in the preparation room 310 and a second docking mechanism 3242 installed in the irradiation room 340 . The first docking mechanism 3241 and the second docking mechanism 3242 can be locked with the treatment bed 322 . Wherein, the position of the simulated irradiation port 321 in the preparation chamber 310 is consistent with the position of the neutron beam exit in the irradiation chamber 340, and the position of the simulated irradiation port 321 relative to the first docking mechanism 3241 is the same as that of the neutron beam exit relative to the second docking mechanism 3241. The positions of the docking mechanisms 3242 are consistent.

The positioning verification device includes a first optical camera 3251, a second optical camera 3252, and an image recognition and processing device. The first optical camera 3251 is arranged directly above the measured object in the preparation room 310, and the second optical camera 3252 is arranged directly above the measured object in the irradiation chamber 340; the first optical camera 3251 and the second The optical cameras 3252 are electrically connected with the image recognition and processing device.

Specifically, the first optical camera 3251 and the second optical camera 3252 are respectively set at the same position directly above the treatment bed 322 in the preparation room 310 and the irradiation room 340, and take pictures of the patient from top to bottom; image recognition and The processing device can extract the contour of the body surface of the patient's body from the photographs taken.

Thus, the patient can be positioned and positioned in the preparation room 310 without the need for medical personnel to enter the irradiation room 340 to complete the positioning and positioning.

During the treatment process, the patient’s target area and normal organs are positioned and positioned on the treatment bed 322 in the preparation room 310 through the positioning device, and the body position is fixed, and then the treatment bed 322 and the patient are moved to the irradiation room by the guide rail 323 340, and then confirm the position to the irradiation position through the position verification device, and then perform neutron beam irradiation according to the treatment plan after confirming the position. Among them, the medical staff can complete the work of positioning the patient and manipulating and executing the treatment plan in the preparation room 310, and then move the patient and the treatment bed 322 into the irradiation room 340. The medical staff do not need to enter the irradiation room 340 to ensure the health of the medical staff Safety, the isolation and shielding room 330 set between the irradiation room 340 and the preparation room 310 can further shield the radiation of the irradiation room 340, further ensuring the health and safety of medical personnel.

As shown in Fig. 2 and Fig. 3, the dose guidance system 400 includes a dose monitoring system, a boron drug infusion system, and a treatment plan adjustment system. The dose monitoring system and the boron drug infusion system are respectively connected with the treatment plan adjustment system, and the treatment plan adjustment system Perform data acquisition and action control on the radiation monitoring system and boron drug infusion system.

Specifically, the dose monitoring system can detect the characteristic gamma ray signal emitted by the nuclear reaction between thermal neutrons irradiating the target area and boron-10, and digitize the detection signal to generate multiple energy channels corresponding to the energy of the incident gamma ray. Spectrum data, through analysis and calculation to obtain the three-dimensional distribution of boron dose and boron-10 concentration in the patient's irradiation target area.

As an improvement of the present invention, the dose monitoring system includes a radiation detection unit 411 and a calculation unit. The radiation detection part is used to detect the prompt gamma photons emitted by the irradiated object and convert them into energy spectrum data, and the calculation part is used to calculate and analyze the energy spectrum data detected by the radiation detection part into boron-10 concentration distribution.

The radiation detection part 411 includes a collimator, a detection body, and a shielding body. The collimation body and the detection body are arranged inside the shielding body. The direct optical signal is converted into electrical signal and energy spectrum data. The collimating holes of the collimating body are evenly arranged in a two-dimensional array. In this embodiment, the collimating body is a grid collimator made of a tungsten plate or a lead plate; the detecting body is composed of a plurality of detecting units, and each detecting unit is Arranged in matrix form, each detection unit includes a detection crystal module, a signal collection and amplification module, and a signal processing module, and the detection crystal module, signal collection and amplification module, and signal processing module are connected in sequence. The signal collection and amplification module amplifies the signal detected by the detection crystal module, and the signal processing module digitizes the amplified signal and generates multi-channel energy spectrum data corresponding to the energy of the incident gamma rays.

Wherein, each collimation hole corresponds to a detector unit, and each detector unit can detect gamma ray signals, and through the grid collimator, the interference signals of scattered rays can be effectively filtered out, and the radiation detection unit 411 can obtain For the incident gamma ray data of the covered plane area, the calculation department can obtain the concentration distribution of the boron-doped drug on the covered plane by analyzing the incident gamma-ray data, wherein the concentration of the boron-doped drug can also be converted into boron- 10 concentration, further, by rotating the radiation detection part 411 around the patient and detecting the measured object in different directions, the detection area can cover the entire measured object, and the calculation part calculates the boron-10 concentration distribution in these different directions Through tomographic analysis, the three-dimensional concentration distribution of boron-10 in the patient can be obtained, and the actual dose distribution of the irradiation area can be obtained more accurately, so that the patient can receive more accurate treatment.

The radiation detection parts 411 are paired and arranged symmetrically around the measured object. By symmetrically arranging the radiation detection parts 411 and combining the anticoincidence circuit, noise gamma photons can be efficiently screened and removed. Specifically, when the neutron beam is irradiated, it will react with boron to generate gamma photons, generally gamma photons with an energy of 478keV, which are the gamma photon signals that need to be detected, but in addition, the neutron beam also needs to be detected during the detection process. It will react with other substances to produce gamma photons, such as the two beams of gamma photons with energy of 511keV and opposite directions released by the annihilation reaction of positron and electron, which interfere to a certain extent with the position and signal of 478keV gamma photons, which is called noise Gamma photons will affect the detection results and need to be removed. In this embodiment, the paired radiation detection units 411 arranged symmetrically can simultaneously detect and distinguish the two beams of noise gamma photons, and then subtract the noise gamma photon signal to eliminate the noise gamma photons. The spatial position of the radiation detection parts 411 can also be adjusted by translation or rotation according to detection needs, and the distance between pairs of radiation detection parts 411 can be adjusted according to detection needs.

In this embodiment, the radiation detection unit 411 is located on the left and right sides of the treatment bed 322 to ensure that the gamma photons emitted by the irradiated target area can be detected.

As an improvement of the present invention, the boron drug infusion system is used to further infuse boron-doped drugs to patients according to needs during BNCT treatment, including an infusion line, an infusion pump, and a boron drug storage container.

In this embodiment, the infusion pump and the boron drug storage container are arranged in the preparation room 310 to avoid being irradiated by the radiation of the irradiation room 340, and the boron-doped drug is introduced into the irradiation room 340 through the infusion line to perform boron-doped treatment on the patient. Drug infusion, in which, in order to reduce the risk of radiation contamination of the infusion line, the infusion line needs to be replaced before each patient is irradiated to ensure that each patient uses an independent set of infusion lines.

As an improvement of the present invention, the treatment plan adjustment system includes a calculation module and an operation module, the calculation module is used to process the information collected from the dose monitoring system and the boron drug infusion system, calculate the adjustment range of irradiation time and supplement the boron drug infusion to generate a radiotherapy plan adjustment scheme, and the operation module is used to display the treatment plan adjustment scheme and operate the treatment plan adjustment scheme. The calculation module obtains the current boron-10 concentration distribution in the irradiation target area from the dose monitoring system, and combines the cumulative irradiation time under the current dose rate to calculate the dose received by the patient during the current detection period. Integral, the deviation between the actual dose received by the patient and the dose in the treatment plan can be obtained, and combined with the current boron-10 concentration distribution, a treatment plan adjustment plan can be generated. Treatment plan adjustment programs include boron-doped drug infusion programs and neutron beam irradiation programs, because the neutron dose received by human tissues is proportional to the neutron beam irradiation time, neutron beam irradiation intensity, and boron-10 concentration.

It should be noted that the neutron beam will pass through normal tissues before reaching the lesion area. For example, the neutron beam needs to pass through the skin to enter the tumor area, and the neutron dose received by the skin cannot exceed the safety standard; on the other hand, The irradiation target area is the area irradiated by the neutron beam, and the lesion area is the area of the patient's tumor. Usually, the irradiation target area is equal to the lesion area, because during the neutron beam irradiation treatment, the beam outlet will adapt to the size of the tumor, so that The irradiation target area covers the lesion area to ensure that the neutron beam only irradiates the tumor area. However, due to the influence of the manufacturing accuracy of the beam exit or the difficulty in confirming the size and boundary of the tumor, the irradiation target area may be slightly larger than the lesion area, which will result in Part of the normal tissue in the border area of the tumor is irradiated with neutron beams. It can be seen from the above that during the treatment process, it is inevitable that some normal tissues will receive neutron beam irradiation, and if the neutron dose is too high, it will cause harm to the human body.

At the same time, during the treatment process, when the neutron dose received by the tumor is insufficient, the neutron beam parameters, such as the irradiation time, are usually adjusted first to ensure that the neutron dose received by the tumor area meets the treatment requirements, but the irradiation time is too long It may cause the neutron dose received by normal tissues to be too high, which will cause harm to the human body. Therefore, it is necessary to control the boron-10 concentration in the tumor area within a certain safe range to ensure that the neutron dose received by normal tissues is safe. To ensure the personal safety of patients within the scope.

For example, if the current boron-10 concentration meets the safety requirements, a neutron beam irradiation plan is generated, and the neutron beam irradiation plan is adjusted in the neutron beam irradiation plan, including irradiation angle, irradiation time, etc. For example, if the current boron-10 concentration does not meet the safety requirements, a boron-doped drug infusion plan is generated, and the boron-doped drug infusion plan is adjusted in the boron-doped drug infusion plan, including the amount of boron-doped drug infused into the patient , to increase the concentration of boron-10 in patients, etc. It avoids the problems of BNCT treatment, such as the decline of tumor control rate due to insufficient irradiation target dose, or the increase of complication rate due to excessive normal tissue dose.

The generated treatment plan adjustment scheme is displayed in the operation module, and the treatment plan adjustment scheme can be executed through the operation module. In this embodiment, the operation module includes a touch screen. The touch screen is placed in the preparation room 310. The generated treatment plan adjustment scheme is displayed on the touch screen. The doctor can select an appropriate treatment plan adjustment scheme according to the needs, and the treatment plan can be adjusted by manipulating the touch screen. The boron-doped drug infusion scheme or neutron beam irradiation scheme in the scheme, wherein, when executing the boron-doped medicine infusion scheme, the operation module needs to control the action of the boron medicine infusion system, and when executing the neutron beam irradiation scheme, the operation module needs to The operation of the neutron irradiation system 200 is controlled.

For example, when the concentration of boron-10 in the irradiation target area matches the treatment plan, the treatment can be carried out according to the treatment plan, and there is no need to adjust the treatment plan.

For example, when the boron-10 concentration in the irradiation target area does not match the treatment plan and the boron-10 concentration is within a safe range, execute the neutron beam irradiation plan, control the neutron irradiation system 200, and adjust the neutron beam parameters.

For example, when the boron-10 concentration in the irradiation target area does not match the treatment plan, and the boron-10 concentration is not within the safe range, implement the boron-doped drug infusion plan, control the boron drug infusion system, and infuse boron-doped drugs into the patient .

As shown in Figure 4, the dose-guided operation method in the boron neutron capture therapy system includes the following steps:

A. Proton beams are provided by the low-energy linear accelerator system 100;

B. Convert proton beams into neutron beams through a neutron beam system;

C. Provide a treatment plan and complete positioning through the treatment assistance system 300;

D. According to the treatment plan, use the neutron beam to irradiate the target area of the patient;

E. Formulate a treatment adjustment plan through the dose guidance system 400;

F. Compare the treatment plan adjustment plan with the treatment plan, and judge whether it is within the acceptable error range. If not, adjust the treatment plan according to the treatment plan adjustment plan and then perform step D. If yes, perform the next step;

G. Compare the actual radiation dose with the treatment plan radiation dose, and judge whether the actual radiation dose reaches the treatment plan radiation dose, if not, proceed to step D, and if so, proceed to the next step;

H. Stop neutron beam irradiation and complete BNCT treatment.

Finally, it should be noted that: the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit them; although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that it still can The technical solutions described in the foregoing embodiments are modified, or some of the technical features are replaced equivalently; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the spirit and scope of the technical solutions of the various embodiments of the present invention.

Claims (10)

1. A dose-guided boron neutron capture therapy system, characterized in that it comprises: A low-energy linear accelerator system (100), used to provide a stable proton beam; The neutron irradiation system (200), including a neutron beam irradiation port (210), is used to provide a therapeutic neutron beam to irradiate the irradiation target area of the object to be irradiated, and is connected to the low-energy linear accelerator system (100); A treatment assisting system (300), used for the positioning of the object to be irradiated during neutron capture tumor treatment, as well as the formulation, verification and execution of treatment plans; The dose guidance system (400), used for dose monitoring and treatment plan adjustment during neutron capture tumor treatment, is respectively connected with the neutron irradiation system (200) and the treatment auxiliary system (300). 2. The dose-guided boron neutron capture therapy system according to claim 1, characterized in that, the dose-guided system (400) comprises a dose monitoring system, a boron drug infusion system, and a treatment plan adjustment system, and the dose The monitoring system and the boron drug infusion system are respectively connected to the treatment plan adjustment system, and the treatment plan adjustment system performs data collection and action control on the dose monitoring system and the boron drug infusion system respectively. 3. The dose-guided boron neutron capture therapy system according to claim 2, characterized in that the dose monitoring system comprises a radiation detection part (411) and a calculation part, and the radiation detection part is used to detect the irradiated object The released prompt gamma photons are converted into energy spectrum data, and the calculation part is used to calculate and analyze the energy spectrum data detected by the radiation detection part into boron-10 concentration distribution. 4. The dose-guided boron neutron capture therapy system according to claim 3, characterized in that, the radiation detection part (411) comprises a collimator, a detection body, a shielding body, the collimator, the The detection body is arranged inside the shielding body, the collimation body is used to collimate the rays emitted by the measured object, and the detection body is used to convert the collimated optical signal into electrical signal and energy spectrum data , the collimating body is provided with collimating holes uniformly arranged in a two-dimensional array. 5. The dose-guided boron neutron capture therapy system according to claim 3, characterized in that, the radiation detection parts (411) are paired and arranged symmetrically around the object to be irradiated, and can surround The illuminated object is rotated. 6. The dose-guided boron neutron capture therapy system according to claim 2, wherein the boron drug infusion system comprises an infusion line, an infusion pump, and a boron drug storage container. 7. The dose-guided boron neutron capture therapy system according to claim 2, characterized in that, the treatment plan adjustment system comprises a calculation module and an operation module, and the calculation module is used to acquire the dose monitoring system, the The data of the boron drug infusion system is reported and a treatment plan adjustment scheme is generated, and the operation module is used for displaying the treatment plan adjustment scheme and controlling execution of the treatment plan adjustment scheme. 8. The dose-guided boron neutron capture therapy system according to claim 1, characterized in that, the treatment assistance system (300) includes a treatment planning system, a control system, a positioning system, a preparation room (310), an isolation shielding room (330) and an irradiation room (340), the isolation shielding room (330) is arranged between the irradiation room (340) and the preparation room (310), and the neutron irradiation system (200) The neutron beam irradiation port (210) is set in the irradiation chamber (340). 9. The dose-guided boron neutron capture therapy system according to claim 8, characterized in that, the positioning and positioning system comprises a simulated irradiation port (321), a treatment couch (322), guide rails (323), automatic alignment position device and set-up verification device, the guide rail (323) is laid in the preparation room (310) and extends into the irradiation room (340), and the treatment bed (322) is along the guide rail (323) moving back and forth between the preparation room (310) and the irradiation room (340). 10. The operation method of the dose-guided boron neutron capture therapy system according to any one of claims 1-9, characterized in that it comprises the following steps: A, providing a proton beam through a low-energy linear accelerator system (100); B, the proton beam is converted into a neutron beam by a neutron irradiation system (200); C. Provide a treatment plan and complete positioning through the treatment assistance system (300); D. According to the treatment plan, use neutron beams to irradiate the target area of the irradiated object; E, develop a treatment plan adjustment scheme through the dose guidance system (400); F. Compare the treatment plan adjustment plan with the treatment plan, and judge whether it is within the acceptable error range. If not, adjust the treatment plan according to the treatment plan adjustment plan and then perform step D. If yes, perform the next step; G. Compare the actual radiation dose with the treatment plan radiation dose, and judge whether the actual radiation dose reaches the treatment plan radiation dose, if not, proceed to step D, and if so, proceed to the next step; H. Stop neutron beam irradiation and complete BNCT treatment.